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Downsample mito bams to prevent eklipse crashes #215

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alkc opened this issue Aug 12, 2024 · 0 comments
Open

Downsample mito bams to prevent eklipse crashes #215

alkc opened this issue Aug 12, 2024 · 0 comments
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enhancement New feature or request

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@alkc
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alkc commented Aug 12, 2024

Mito genomes w/ coverages reaching 40-60k crash eklipse, in contrast our QC guidelines mandate a minimum mean coverage of 500x, which is well under 40000-60000x

We should probably downsample to maybe 5000x, or even lower?

This update would most likely require a rerun of the mito validation samples.

@alkc alkc added the enhancement New feature or request label Aug 12, 2024
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