diff --git a/ddtrace/appsec/_iast/_taint_tracking/_native.cpp b/ddtrace/appsec/_iast/_taint_tracking/_native.cpp
index e0a64332431..f6ebe354c6b 100644
--- a/ddtrace/appsec/_iast/_taint_tracking/_native.cpp
+++ b/ddtrace/appsec/_iast/_taint_tracking/_native.cpp
@@ -72,6 +72,12 @@ PYBIND11_MODULE(_native, m)
     }
 
     initializer = make_unique<Initializer>();
+    // Create an atexit callback to clean up the Initializer before the interpreter finishes
+    auto atexit_register = py::module_::import("atexit").attr("register");
+    atexit_register(py::cpp_function([]() {
+        initializer->reset_context();
+        initializer.reset();
+    }));
     initializer->create_context();
 
     m.doc() = "Native Python module";
diff --git a/releasenotes/notes/initializer-atexit-6f9a025488fe14b4.yaml b/releasenotes/notes/initializer-atexit-6f9a025488fe14b4.yaml
new file mode 100644
index 00000000000..c1fe5fc835d
--- /dev/null
+++ b/releasenotes/notes/initializer-atexit-6f9a025488fe14b4.yaml
@@ -0,0 +1,4 @@
+---
+fixes:
+  - |
+    Code Security: ensure the ``Initializer`` object is always reset and freed before the Python runtime.