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The Kidney Tissue Atlas Ontology (KTAO) is an ontology that integrates kidney-related cell types, cell states, locations, gene markers, disease, etc., and their relations.

KTAO is developed to support the NIH-NIDDK-funed Kidney Precision Medicine Project (KPMP, http://kpmp.org). The KTAO development is also supported by the KPMP project.

This GitHub website is the home page of KTAO.

Note: KTAO is developed simultaneously with the community-based [Ontology of Precision Medicine and Investigation (OPMI)] (https://github.com/OPMI/opmi). KTAO and OPMI are complementary with each other. OPMI includes many precision medicine-related terms that are general and can be used in KTAO and beyond KTAO. KTAO is developed with more kidney-specific information. To support kidney-specific KPMP tasks, KTAO also imports related terms from OPMI.

KTAO developers

  • Y. Oliver He
  • Edison Ong
  • Yingtong Liu
  • Ghida Arnous
  • Lia Papageorge
  • Jennifer Schaub
  • Eric Ling Wan
  • Sean Mooney
  • Becky Steck
  • Michael Todd Valerius
  • Contributors: George Oliver, Matthias Kretzler, Chrysta Lienczewski, Deborah Hoshizaki, Evren Azeloglu, John F. Bertram, Jonathan Himmelfarb, Laura Mariani, Ravi Iyengar, Ulysses Balis, John O'Toole
  • The KPMP Consortium

Download

Use the following URI to download this ontology

Note that the source ontology is an OWL file.

Browsing

Publications

  • Ong E, Wang LL, Schaub J, O'Toole JF, Steck B, Rosenberg AZ, Dowd F, Hansen J, Barisoni L, Jain S, de Boer IH, Valerius MT, Waikar SS, Park C, Crawford DC, Alexandrov T, Anderton CR, Stoeckert C, Weng C, Diehl AD, Mungall CJ, Haendel M, Robinson PN, Himmelfarb J, Iyengar R, Kretzler M, Mooney S, and He Y, Kidney Precision Medicine Project. Modeling Kidney Disease Using Ontology: Perspectives from the KPMP. Nature Review Nephrology. 2020 Sep 16. doi: 10.1038/s41581-020-00335-w. Online ahead of print. PMID: 32939051.

  • He Y, Steck B, Ong E, Mariani L, Lienczewski C, Balis U, Kretzler M, Himmelfarb J, Bertram JF, Azeloglu E, Iyengar R, Hoshizaki D, Mooney SD, for the KPMP Consortium. KTAO: A kidney tissue atlas ontology to support community-based kidney knowledge base development and data integration. International Conference on Biomedical Ontology 2018 (ICBO-2018), August 7-10, 2018, Corvallis, Oregon, USA. Full length paper. Pages 1-6. URL: http://ceur-ws.org/Vol-2285/ICBO_2018_paper_28.pdf .