Skip to content

Desirable Compounds Not Yet Synthesised

Jump to bottom
MFernflower edited this page Nov 15, 2018 · 29 revisions

Furanyl analogue (most important as of nov 2018):

SMILES: NC1=C2C(C=C(C3=CC=CC(S(=O)(N)=O)=C3)O2)=NC=N1 InChI=1S/C12H10N4O3S/c13-12-11-9(15-6-16-12)5-10(19-11)7-2-1-3-8(4-7)20(14,17)18/h1-6H,(H2,13,15,16)(H2,14,17,18)

Laboratory efforts are currently going towards producing the furanyl analogue of OSM-S-106 (image above) - Discussion of synthetic chemistry, Google Doc describing detailed synthetic progress.

Other possible molecules of interest:

A small library of compounds was proposed by Mandrake (Anthony) in 2017 based on the idea of mimicking ATP - compounds in green boxes should have somewhat decent cellular permeability:

Background

OSM Series 3

Aims and Current Interest in Series 3

Sources of Data

Mechanism of Action, Activity and Toxicity

Mechanism of Action

Synthetic Chemistry

Synthesis of the Original Hit

Desirable Compounds Not Yet Synthesised

Structure-Activity Relationships

The Data on the Original Hit

All Analogs Evaluated to Date

Compounds Synthesised But Not Evaluated

The Surrounding Chemical Space

Misc

Funding for this Series

Clone this wiki locally