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Desirable Compounds Not Yet Synthesised

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MFernflower edited this page Oct 23, 2018 · 29 revisions

Links needed in this section to failed attempts,or suggestions that are promising, along with their rationale. As of Feb 2018, the following constitute the DCNYS's.

All laboratory efforts are currently going towards producing the furanyl analogue of OSM-S-106 (image above) - Discussion of synthetic chemistry

SMILES: NC1=C2C(C=C(C3=CC=CC(S(=O)(N)=O)=C3)O2)=NC=N1

InChI=1S/C12H10N4O3S/c13-12-11-9(15-6-16-12)5-10(19-11)7-2-1-3-8(4-7)20(14,17)18/h1-6H,(H2,13,15,16)(H2,14,17,18)

Additionally a small library of compounds was proposed by Mandrake (Anthony) in 2017 based on the idea of mimicking ATP - compounds in green boxes should have somewhat decent cellular permeability:

Background

OSM Series 3

Aims and Current Interest in Series 3

Sources of Data

Mechanism of Action, Activity and Toxicity

Mechanism of Action

Synthetic Chemistry

Synthesis of the Original Hit

Desirable Compounds Not Yet Synthesised

Structure-Activity Relationships

The Data on the Original Hit

All Analogs Evaluated to Date

Compounds Synthesised But Not Evaluated

The Surrounding Chemical Space

Misc

Funding for this Series

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