diff --git a/src/Maui/Prism.Maui/Ioc/RegionNavigationRegistrationExtensions.cs b/src/Maui/Prism.Maui/Ioc/RegionNavigationRegistrationExtensions.cs
index 94d52f7cf..800affcd5 100644
--- a/src/Maui/Prism.Maui/Ioc/RegionNavigationRegistrationExtensions.cs
+++ b/src/Maui/Prism.Maui/Ioc/RegionNavigationRegistrationExtensions.cs
@@ -114,7 +114,8 @@ internal static IContainerRegistry RegisterRegionServices(this IContainerRegistr
             // TODO: CollectionView is buggy with only last View showing despite multiple Active Views
             // BUG: iOS Crash with CollectionView https://github.com/xamarin/Xamarin.Forms/issues/9970
             //regionAdapterMappings.RegisterDefaultMapping<CollectionView, CollectionViewRegionAdapter>();
-            regionAdapterMappings.RegisterDefaultMapping<Layout, LayoutViewRegionAdapter>();
+            regionAdapterMappings.RegisterDefaultMapping<Microsoft.Maui.Controls.Compatibility.Layout<View>, LayoutViewRegionAdapter>();
+            regionAdapterMappings.RegisterDefaultMapping<Layout, LayoutRegionAdapter>();
             regionAdapterMappings.RegisterDefaultMapping<ScrollView, ScrollViewRegionAdapter>();
             regionAdapterMappings.RegisterDefaultMapping<ContentView, ContentViewRegionAdapter>();
             return regionAdapterMappings;
diff --git a/src/Maui/Prism.Maui/Navigation/Regions/Adapters/LayoutRegionAdapter.cs b/src/Maui/Prism.Maui/Navigation/Regions/Adapters/LayoutRegionAdapter.cs
new file mode 100644
index 000000000..8b4008c50
--- /dev/null
+++ b/src/Maui/Prism.Maui/Navigation/Regions/Adapters/LayoutRegionAdapter.cs
@@ -0,0 +1,50 @@
+using Prism.Properties;
+
+namespace Prism.Navigation.Regions.Adapters;
+
+/// <summary>
+/// Adapter that creates a new <see cref="Region"/> and monitors its
+/// active view to set it on the adapted <see cref="Layout"/>.
+/// </summary>
+public class LayoutRegionAdapter : RegionAdapterBase<Layout>
+{
+    /// <summary>
+    /// Initializes a new instance of <see cref="LayoutRegionAdapter"/>.
+    /// </summary>
+    /// <param name="regionBehaviorFactory">The factory used to create the region behaviors to attach to the created regions.</param>
+    public LayoutRegionAdapter(IRegionBehaviorFactory regionBehaviorFactory)
+        : base(regionBehaviorFactory)
+    {
+    }
+
+    /// <summary>
+    /// Adapts a <see cref="Layout"/> to an <see cref="IRegion"/>.
+    /// </summary>
+    /// <param name="region">The new region being used.</param>
+    /// <param name="regionTarget">The object to adapt.</param>
+    protected override void Adapt(IRegion region, Layout regionTarget)
+    {
+        if (region == null)
+            throw new ArgumentNullException(nameof(region));
+
+        if (regionTarget == null)
+            throw new ArgumentNullException(nameof(regionTarget));
+
+        bool itemsSourceIsSet = regionTarget.Children?.Any() ?? false || regionTarget.IsSet(BindableLayout.ItemsSourceProperty);
+
+        if (itemsSourceIsSet)
+        {
+            throw new InvalidOperationException(Resources.LayoutViewHasChildrenException);
+        }
+
+        BindableLayout.SetItemsSource(regionTarget, region.Views);
+        BindableLayout.SetItemTemplate(regionTarget, new RegionItemsSourceTemplate());
+    }
+
+    /// <summary>
+    /// Creates a new instance of <see cref="IRegion"/>.
+    /// </summary>
+    /// <returns>A new instance of <see cref="Region"/>.</returns>
+    protected override IRegion CreateRegion(IContainerProvider container) =>
+        container.Resolve<Region>();
+}
diff --git a/src/Maui/Prism.Maui/Navigation/Regions/Adapters/LayoutViewRegionAdapter.cs b/src/Maui/Prism.Maui/Navigation/Regions/Adapters/LayoutViewRegionAdapter.cs
index 56349f75b..9d2c591b7 100644
--- a/src/Maui/Prism.Maui/Navigation/Regions/Adapters/LayoutViewRegionAdapter.cs
+++ b/src/Maui/Prism.Maui/Navigation/Regions/Adapters/LayoutViewRegionAdapter.cs
@@ -1,12 +1,13 @@
+using Microsoft.Maui.Controls.Compatibility;
 using Prism.Properties;
 
 namespace Prism.Navigation.Regions.Adapters;
 
 /// <summary>
 /// Adapter that creates a new <see cref="Region"/> and monitors its
-/// active view to set it on the adapted <see cref="Layout"/>.
+/// active view to set it on the adapted <see cref="Layout{View}"/>.
 /// </summary>
-public class LayoutViewRegionAdapter : RegionAdapterBase<Layout>
+public class LayoutViewRegionAdapter : RegionAdapterBase<Layout<View>>
 {
     /// <summary>
     /// Initializes a new instance of <see cref="LayoutViewRegionAdapter"/>.
@@ -18,11 +19,11 @@ public LayoutViewRegionAdapter(IRegionBehaviorFactory regionBehaviorFactory)
     }
 
     /// <summary>
-    /// Adapts a <see cref="Layout"/> to an <see cref="IRegion"/>.
+    /// Adapts a <see cref="Layout{View}"/> to an <see cref="IRegion"/>.
     /// </summary>
     /// <param name="region">The new region being used.</param>
     /// <param name="regionTarget">The object to adapt.</param>
-    protected override void Adapt(IRegion region, Layout regionTarget)
+    protected override void Adapt(IRegion region, Layout<View> regionTarget)
     {
         if (region == null)
             throw new ArgumentNullException(nameof(region));