diff --git a/packages/cli/src/lifecycles/serve.js b/packages/cli/src/lifecycles/serve.js
index ea8991f2f..b11bcb21c 100644
--- a/packages/cli/src/lifecycles/serve.js
+++ b/packages/cli/src/lifecycles/serve.js
@@ -307,15 +307,20 @@ async function getHybridServer(compilation) {
 
         ctx.body = Readable.from(response.body);
         ctx.set('Content-Type', 'text/html');
+        // TODO should use status from response
+        // https://github.com/ProjectEvergreen/greenwood/issues/1048
         ctx.status = 200;
       } else if (isApiRoute) {
         const apiRoute = manifest.apis.get(url.pathname);
         const { handler } = await import(new URL(`.${apiRoute.path}`, outputDir));
         const response = await handler(request);
+        const { body } = response;
 
+        // TODO should use status from response
+        // https://github.com/ProjectEvergreen/greenwood/issues/1048
+        ctx.body = body ? Readable.from(body) : null;
         ctx.status = 200;
         ctx.set('Content-Type', response.headers.get('Content-Type'));
-        ctx.body = Readable.from(response.body);
       }
     } catch (e) {
       ctx.status = 500;
diff --git a/packages/cli/src/plugins/resource/plugin-node-modules.js b/packages/cli/src/plugins/resource/plugin-node-modules.js
index b12dd3fe0..475efbf18 100644
--- a/packages/cli/src/plugins/resource/plugin-node-modules.js
+++ b/packages/cli/src/plugins/resource/plugin-node-modules.js
@@ -66,7 +66,7 @@ class NodeModulesResource extends ResourceInterface {
   }
 
   async shouldIntercept(url, request, response) {
-    return response.headers.get('Content-Type').indexOf('text/html') >= 0;
+    return response.headers.get('Content-Type')?.indexOf('text/html') >= 0;
   }
 
   async intercept(url, request, response) {
diff --git a/packages/cli/src/plugins/server/plugin-livereload.js b/packages/cli/src/plugins/server/plugin-livereload.js
index 07d2eb120..e3303e616 100644
--- a/packages/cli/src/plugins/server/plugin-livereload.js
+++ b/packages/cli/src/plugins/server/plugin-livereload.js
@@ -54,7 +54,7 @@ class LiveReloadResource extends ResourceInterface {
   async shouldIntercept(url, request, response) {
     const contentType = response.headers.get('Content-Type');
 
-    return contentType.indexOf('text/html') >= 0 && process.env.__GWD_COMMAND__ === 'develop'; // eslint-disable-line no-underscore-dangle
+    return contentType?.indexOf('text/html') >= 0 && process.env.__GWD_COMMAND__ === 'develop'; // eslint-disable-line no-underscore-dangle
   }
 
   async intercept(url, request, response) {
diff --git a/packages/cli/test/cases/develop.default/develop.default.spec.js b/packages/cli/test/cases/develop.default/develop.default.spec.js
index 9735f6fd3..0136a1ce1 100644
--- a/packages/cli/test/cases/develop.default/develop.default.spec.js
+++ b/packages/cli/test/cases/develop.default/develop.default.spec.js
@@ -19,6 +19,7 @@
  * src/
  *   api/
  *     greeting.js
+ *     nothing.js
  *   assets/
  *     data.json
  *     favicon.ico
@@ -1348,6 +1349,28 @@ describe('Develop Greenwood With: ', function() {
         done();
       });
     });
+
+    describe('Develop command with API specific behaviors with a minimal response', function() {
+      let response = {};
+
+      before(async function() {
+        return new Promise((resolve, reject) => {
+          request.get(`${hostname}:${port}/api/nothing`, (err, res) => {
+            if (err) {
+              reject();
+            }
+
+            response = res;
+            resolve();
+          });
+        });
+      });
+
+      it('should return a 200 status', function(done) {
+        expect(response.statusCode).to.equal(200);
+        done();
+      });
+    });
   });
 
   after(function() {
diff --git a/packages/cli/test/cases/develop.default/src/api/nothing.js b/packages/cli/test/cases/develop.default/src/api/nothing.js
new file mode 100644
index 000000000..4f49b7fb3
--- /dev/null
+++ b/packages/cli/test/cases/develop.default/src/api/nothing.js
@@ -0,0 +1,5 @@
+export async function handler() {
+  // TODO should support a non 200 status code
+  // https://github.com/ProjectEvergreen/greenwood/issues/1048
+  return new Response(undefined);
+}
\ No newline at end of file
diff --git a/packages/cli/test/cases/serve.default.api/serve.default.api.spec.js b/packages/cli/test/cases/serve.default.api/serve.default.api.spec.js
index 9144881e5..c7e88120b 100644
--- a/packages/cli/test/cases/serve.default.api/serve.default.api.spec.js
+++ b/packages/cli/test/cases/serve.default.api/serve.default.api.spec.js
@@ -37,7 +37,7 @@ describe('Serve Greenwood With: ', function() {
     this.context = {
       hostname
     };
-    runner = new Runner();
+    runner = new Runner(true);
   });
 
   describe(LABEL, function() {
@@ -129,6 +129,28 @@ describe('Serve Greenwood With: ', function() {
       });
     });
 
+    describe('Serve command with API specific behaviors with a minimal response', function() {
+      let response = {};
+
+      before(async function() {
+        return new Promise((resolve, reject) => {
+          request.get(`${hostname}/api/nothing`, (err, res) => {
+            if (err) {
+              reject();
+            }
+
+            response = res;
+            resolve();
+          });
+        });
+      });
+
+      it('should return a 200 status', function(done) {
+        expect(response.statusCode).to.equal(200);
+        done();
+      });
+    });
+
     describe('Serve command with API 404 not found behavior', function() {
       let response = {};
 
diff --git a/packages/cli/test/cases/serve.default.api/src/api/nothing.js b/packages/cli/test/cases/serve.default.api/src/api/nothing.js
new file mode 100644
index 000000000..4596641aa
--- /dev/null
+++ b/packages/cli/test/cases/serve.default.api/src/api/nothing.js
@@ -0,0 +1,3 @@
+export async function handler() {
+  return new Response(undefined);
+}
\ No newline at end of file
diff --git a/packages/plugin-google-analytics/src/index.js b/packages/plugin-google-analytics/src/index.js
index 455cc8750..d100dd72f 100644
--- a/packages/plugin-google-analytics/src/index.js
+++ b/packages/plugin-google-analytics/src/index.js
@@ -14,7 +14,7 @@ class GoogleAnalyticsResource extends ResourceInterface {
   }
 
   async shouldIntercept(url, request, response) {
-    return response.headers.get('Content-Type').indexOf(this.contentType) >= 0;
+    return response.headers.get('Content-Type')?.indexOf(this.contentType) >= 0;
   }
 
   async intercept(url, request, response) {
diff --git a/packages/plugin-graphql/src/index.js b/packages/plugin-graphql/src/index.js
index 7edd95642..cf0c4cb00 100644
--- a/packages/plugin-graphql/src/index.js
+++ b/packages/plugin-graphql/src/index.js
@@ -40,7 +40,7 @@ class GraphQLResource extends ResourceInterface {
   }
 
   async shouldIntercept(url, request, response) {
-    return response.headers.get('Content-Type').indexOf(this.contentType[1]) >= 0;
+    return response.headers.get('Content-Type')?.indexOf(this.contentType[1]) >= 0;
   }
 
   async intercept(url, request, response) {
diff --git a/packages/plugin-include-html/src/index.js b/packages/plugin-include-html/src/index.js
index 12682e661..20160a44f 100644
--- a/packages/plugin-include-html/src/index.js
+++ b/packages/plugin-include-html/src/index.js
@@ -9,7 +9,7 @@ class IncludeHtmlResource extends ResourceInterface {
   }
 
   async shouldIntercept(url, request, response) {
-    return response.headers.get('Content-Type').indexOf(this.contentType) >= 0;
+    return response.headers.get('Content-Type')?.indexOf(this.contentType) >= 0;
   }
 
   async intercept(url, request, response) {
diff --git a/packages/plugin-polyfills/src/index.js b/packages/plugin-polyfills/src/index.js
index e56252bd5..358a95afc 100644
--- a/packages/plugin-polyfills/src/index.js
+++ b/packages/plugin-polyfills/src/index.js
@@ -21,7 +21,7 @@ class PolyfillsResource extends ResourceInterface {
 
     return isEnabled
       && protocol.startsWith('http')
-      && response.headers.get('Content-Type').indexOf(this.contentType) >= 0;
+      && response.headers.get('Content-Type')?.indexOf(this.contentType) >= 0;
   }
 
   async intercept(url, request, response) {
diff --git a/packages/plugin-renderer-puppeteer/src/plugins/resource.js b/packages/plugin-renderer-puppeteer/src/plugins/resource.js
index 509f2faaf..4fd97a306 100644
--- a/packages/plugin-renderer-puppeteer/src/plugins/resource.js
+++ b/packages/plugin-renderer-puppeteer/src/plugins/resource.js
@@ -13,7 +13,7 @@ class PuppeteerResource extends ResourceInterface {
 
     return process.env.__GWD_COMMAND__ === 'build' // eslint-disable-line no-underscore-dangle
       && protocol.startsWith('http')
-      && response.headers.get('Content-Type').indexOf(this.contentType) >= 0;
+      && response.headers.get('Content-Type')?.indexOf(this.contentType) >= 0;
   }
 
   async intercept(url, request, response) {