diff --git a/test/py/CMakeLists.txt b/test/py/CMakeLists.txt
index 634e6114520..b0662c9924f 100755
--- a/test/py/CMakeLists.txt
+++ b/test/py/CMakeLists.txt
@@ -1,7 +1,7 @@
 #####################################################################################
 # The MIT License (MIT)
 #
-# Copyright (c) 2015-2022 Advanced Micro Devices, Inc. All rights reserved.
+# Copyright (c) 2015-2023 Advanced Micro Devices, Inc. All rights reserved.
 #
 # Permission is hereby granted, free of charge, to any person obtaining a copy
 # of this software and associated documentation files (the "Software"), to deal
@@ -23,8 +23,14 @@
 #####################################################################################
 
 include(PythonModules)
+set(VENV ${CMAKE_BINARY_DIR}/test/py/venv)
+set(VENV_ONNX ${CMAKE_BINARY_DIR}/test/py/venv-onnx)
+set(REQUIREMENTS ${CMAKE_CURRENT_SOURCE_DIR}/requirements.txt)
+set(REQUIREMENTS_ONNX ${CMAKE_CURRENT_SOURCE_DIR}/requirements-onnx.txt)
+set(PYTHON_VERSION_TO_DISABLE_ONNX 3.6)
 
-function(add_py_test NAME SCRIPT)
+
+function(add_py_venv_fixture FIXTURE_NAME VIRTUAL_ENV_DIR REQUIREMENTS_FILE)
     foreach(PYTHON_VERSION ${PYTHON_VERSIONS})
         set (ENV_COMMAND ${CMAKE_COMMAND} -E env 
             "PYTHONPATH=$<TARGET_FILE_DIR:migraphx_pybind_${PYTHON_VERSION}>"
@@ -32,28 +38,57 @@ function(add_py_test NAME SCRIPT)
             "MALLOC_CHECK_=3"
         )
         set(PYTHON_EXECUTABLE ${PYTHON_${PYTHON_VERSION}_EXECUTABLE})
-        add_test(
-            NAME test_py_${PYTHON_VERSION}_${NAME} 
-            COMMAND ${ENV_COMMAND} ${PYTHON_EXECUTABLE} ${CMAKE_CURRENT_SOURCE_DIR}/${SCRIPT} ${ARGN})
-        add_custom_target(test_py_${PYTHON_VERSION}_${NAME} 
-            COMMAND ${ENV_COMMAND} ${PYTHON_EXECUTABLE} ${CMAKE_CURRENT_SOURCE_DIR}/${SCRIPT} ${ARGN} 
-            COMMENT "${PYTHON_EXECUTABLE} ${SCRIPT}")
 
+        if(NOT TEST py_${PYTHON_VERSION}_${FIXTURE_NAME}_initialize_env)
+            if (NOT (${FIXTURE_NAME} STREQUAL "onnx" AND ${PYTHON_VERSION} STREQUAL ${PYTHON_VERSION_TO_DISABLE_ONNX}))
+                add_test(NAME py_${PYTHON_VERSION}_${FIXTURE_NAME}_initialize_env COMMAND ${PYTHON_EXECUTABLE} -m venv ${VIRTUAL_ENV_DIR}/${PYTHON_VERSION} --clear)
+                set_tests_properties(py_${PYTHON_VERSION}_${FIXTURE_NAME}_initialize_env PROPERTIES FIXTURES_SETUP ${FIXTURE_NAME}_${PYTHON_VERSION}_INIT_VENV)
+                set(PYTHON_EXECUTABLE ${VIRTUAL_ENV_DIR}/${PYTHON_VERSION}/bin/python)
+                add_test(
+                    NAME py_${PYTHON_VERSION}_${FIXTURE_NAME}_setup_env
+                    COMMAND ${PYTHON_EXECUTABLE} -m pip install -r ${REQUIREMENTS_FILE})
+                set_tests_properties(py_${PYTHON_VERSION}_${FIXTURE_NAME}_setup_env PROPERTIES FIXTURES_REQUIRED ${FIXTURE_NAME}_${PYTHON_VERSION}_INIT_VENV)
+                set_tests_properties(py_${PYTHON_VERSION}_${FIXTURE_NAME}_setup_env PROPERTIES FIXTURES_SETUP ${FIXTURE_NAME}_${PYTHON_VERSION}_VENV)
+            endif()
+        endif()
+    endforeach()
+endfunction()
+
+function(add_py_test NAME SCRIPT FIXTURE_NAME VENV_DIR)
+    foreach(PYTHON_VERSION ${PYTHON_VERSIONS})
+        set (ENV_COMMAND ${CMAKE_COMMAND} -E env
+            "PYTHONPATH=$<TARGET_FILE_DIR:migraphx_pybind_${PYTHON_VERSION}>"
+            "PYTHONMALLOC=debug"
+            "MALLOC_CHECK_=3"
+        )
+        set(PYTHON_EXECUTABLE ${VENV_DIR}/${PYTHON_VERSION}/bin/python)
+        if(NOT (${FIXTURE_NAME} STREQUAL "onnx" AND ${PYTHON_VERSION} STREQUAL ${PYTHON_VERSION_TO_DISABLE_ONNX}))
+            add_test(
+                NAME test_py_${PYTHON_VERSION}_${NAME}
+                COMMAND ${ENV_COMMAND} ${PYTHON_EXECUTABLE} ${CMAKE_CURRENT_SOURCE_DIR}/${SCRIPT} ${ARGN})
+            set_tests_properties(test_py_${PYTHON_VERSION}_${NAME} PROPERTIES FIXTURES_REQUIRED ${FIXTURE_NAME}_${PYTHON_VERSION}_VENV)
+            add_custom_target(test_py_${PYTHON_VERSION}_${NAME}
+                COMMAND ${ENV_COMMAND} ${PYTHON_EXECUTABLE} ${CMAKE_CURRENT_SOURCE_DIR}/${SCRIPT} ${ARGN}
+                COMMENT "${PYTHON_EXECUTABLE} ${SCRIPT}")
+        endif()
     endforeach()
 endfunction()
 add_dependencies(tests migraphx_py)
 add_dependencies(check migraphx_py)
 
-add_py_test(ref test_cpu.py WORKING_DIRECTORY ${TEST_ONNX_DIR})
-add_py_test(save_load test_save_load.py WORKING_DIRECTORY ${TEST_ONNX_DIR})
-add_py_test(op test_op.py WORKING_DIRECTORY ${TEST_ONNX_DIR})
-add_py_test(shape test_shape.py WORKING_DIRECTORY ${TEST_ONNX_DIR})
-add_py_test(module_construct test_module_construct.py WORKING_DIRECTORY ${TEST_ONNX_DIR})
-add_py_test(literal test_literal.py WORKING_DIRECTORY ${TEST_ONNX_DIR})
+add_py_venv_fixture(common ${VENV} ${REQUIREMENTS})
+add_py_venv_fixture(onnx ${VENV_ONNX} ${REQUIREMENTS_ONNX})
+
+add_py_test(ref test_cpu.py common ${VENV} WORKING_DIRECTORY ${TEST_ONNX_DIR})
+add_py_test(save_load test_save_load.py common ${VENV} WORKING_DIRECTORY ${TEST_ONNX_DIR})
+add_py_test(op test_op.py common ${VENV} WORKING_DIRECTORY ${TEST_ONNX_DIR})
+add_py_test(shape test_shape.py common ${VENV} WORKING_DIRECTORY ${TEST_ONNX_DIR})
+add_py_test(module_construct test_module_construct.py common ${VENV} WORKING_DIRECTORY ${TEST_ONNX_DIR})
+add_py_test(literal test_literal.py common ${VENV} WORKING_DIRECTORY ${TEST_ONNX_DIR})
 if(MIGRAPHX_ENABLE_GPU)
-add_py_test(gpu_offload test_gpu_offload.py WORKING_DIRECTORY ${TEST_ONNX_DIR})
-add_py_test(gpu test_gpu.py WORKING_DIRECTORY ${TEST_ONNX_DIR})
-add_py_test(array test_array.py WORKING_DIRECTORY ${TEST_ONNX_DIR})
-add_py_test(backend onnx_backend_test.py WORKING_DIRECTORY ${TEST_ONNX_DIR})
-add_py_test(gpu_async test_gpu_async.py WORKING_DIRECTORY ${TEST_ONNX_DIR})
+add_py_test(gpu_offload test_gpu_offload.py common ${VENV} WORKING_DIRECTORY ${TEST_ONNX_DIR})
+add_py_test(gpu test_gpu.py common ${VENV} WORKING_DIRECTORY ${TEST_ONNX_DIR})
+add_py_test(array test_array.py common ${VENV} WORKING_DIRECTORY ${TEST_ONNX_DIR})
+add_py_test(backend onnx_backend_test.py onnx ${VENV_ONNX} WORKING_DIRECTORY ${TEST_ONNX_DIR})
+add_py_test(gpu_async test_gpu_async.py common ${VENV} WORKING_DIRECTORY ${TEST_ONNX_DIR})
 endif()
diff --git a/test/py/requirements-onnx.txt b/test/py/requirements-onnx.txt
new file mode 100644
index 00000000000..fc6964ec664
--- /dev/null
+++ b/test/py/requirements-onnx.txt
@@ -0,0 +1,29 @@
+#####################################################################################
+# The MIT License (MIT)
+#
+# Copyright (c) 2015-2023 Advanced Micro Devices, Inc. All rights reserved.
+#
+# Permission is hereby granted, free of charge, to any person obtaining a copy
+# of this software and associated documentation files (the "Software"), to deal
+# in the Software without restriction, including without limitation the rights
+# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
+# copies of the Software, and to permit persons to whom the Software is
+# furnished to do so, subject to the following conditions:
+#
+# The above copyright notice and this permission notice shall be included in
+# all copies or substantial portions of the Software.
+#
+# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
+# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
+# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT.  IN NO EVENT SHALL THE
+# AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
+# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
+# OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
+# THE SOFTWARE.
+#####################################################################################
+
+onnx==1.14.1
+protobuf==3.20.2
+numpy==1.21.6
+packaging==23.0
+pytest==6.0.1
\ No newline at end of file
diff --git a/test/py/requirements.txt b/test/py/requirements.txt
new file mode 100644
index 00000000000..dda4d2dc228
--- /dev/null
+++ b/test/py/requirements.txt
@@ -0,0 +1,25 @@
+#####################################################################################
+# The MIT License (MIT)
+#
+# Copyright (c) 2015-2023 Advanced Micro Devices, Inc. All rights reserved.
+#
+# Permission is hereby granted, free of charge, to any person obtaining a copy
+# of this software and associated documentation files (the "Software"), to deal
+# in the Software without restriction, including without limitation the rights
+# to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
+# copies of the Software, and to permit persons to whom the Software is
+# furnished to do so, subject to the following conditions:
+#
+# The above copyright notice and this permission notice shall be included in
+# all copies or substantial portions of the Software.
+#
+# THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
+# IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
+# FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT.  IN NO EVENT SHALL THE
+# AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
+# LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
+# OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
+# THE SOFTWARE.
+#####################################################################################
+
+numpy==1.21.6
\ No newline at end of file
diff --git a/tools/install_prereqs.sh b/tools/install_prereqs.sh
index 1deefb9a042..7ba0f37e181 100755
--- a/tools/install_prereqs.sh
+++ b/tools/install_prereqs.sh
@@ -3,7 +3,7 @@
 #####################################################################################
 # The MIT License (MIT)
 #
-# Copyright (c) 2015-2022 Advanced Micro Devices, Inc. All rights reserved.
+# Copyright (c) 2015-2023 Advanced Micro Devices, Inc. All rights reserved.
 #
 # Permission is hereby granted, free of charge, to any person obtaining a copy
 # of this software and associated documentation files (the "Software"), to deal
@@ -51,6 +51,7 @@ else
     openmp-extras \
     python3-dev \
     python3-pip \
+    python3-venv \
     rocblas-dev \
     rocm-cmake
 fi