diff --git a/src/cascader/utils/helper.ts b/src/cascader/utils/helper.ts
index 336748c53e..dacf04b4f4 100644
--- a/src/cascader/utils/helper.ts
+++ b/src/cascader/utils/helper.ts
@@ -35,6 +35,14 @@ export const getTreeValue = (value: CascaderContextType['value']) => {
   return treeValue;
 };
 
+/**
+ * 判断node是否在页面上
+ * @param node Node
+ */
+export function isInPage(node: Node) {
+  return node === document.body ? false : document.body.contains(node);
+}
+
 export default {
   getFullPathLabel,
 };
diff --git a/src/cascader/utils/inputContent.ts b/src/cascader/utils/inputContent.ts
index f695f18ba4..af2e96ec63 100644
--- a/src/cascader/utils/inputContent.ts
+++ b/src/cascader/utils/inputContent.ts
@@ -1,6 +1,7 @@
 import isFunction from 'lodash/isFunction';
 import isEmpty from 'lodash/isEmpty';
 import { TreeNode, CascaderContextType, TreeNodeValue, CascaderProps } from '../interface';
+import { isInPage } from './helper';
 
 /**
  * icon Class
@@ -147,13 +148,10 @@ export function outerClickListenerEffect(
   event: MouseEvent | TouchEvent,
 ) {
   const { visible, setVisible } = cascaderContext;
-  if (!ref || ref.contains(event.target as Node)) {
-    return;
-  }
-
-  if (visible) {
-    setVisible(false);
-  }
+  const target = event.target as Node;
+  // 可能点击的dom在判断的时候已经被移除了
+  if (!visible || !ref || ref.contains(target) || !isInPage(target)) return;
+  setVisible(false);
 }
 
 /**