diff --git a/tests/test_resend_integration.py b/tests/test_resend_integration.py
new file mode 100644
index 00000000..ec260d0b
--- /dev/null
+++ b/tests/test_resend_integration.py
@@ -0,0 +1,91 @@
+import os
+import unittest
+from email.utils import formataddr
+
+from django.test import SimpleTestCase, override_settings, tag
+
+from anymail.exceptions import AnymailAPIError
+from anymail.message import AnymailMessage
+
+from .utils import AnymailTestMixin
+
+ANYMAIL_TEST_RESEND_API_KEY = os.getenv("ANYMAIL_TEST_RESEND_API_KEY")
+ANYMAIL_TEST_RESEND_DOMAIN = os.getenv("ANYMAIL_TEST_RESEND_DOMAIN")
+
+
+@tag("resend", "live")
+@unittest.skipUnless(
+    ANYMAIL_TEST_RESEND_API_KEY and ANYMAIL_TEST_RESEND_DOMAIN,
+    "Set ANYMAIL_TEST_RESEND_API_KEY and ANYMAIL_TEST_RESEND_DOMAIN "
+    "environment variables to run Resend integration tests",
+)
+@override_settings(
+    ANYMAIL_RESEND_API_KEY=ANYMAIL_TEST_RESEND_API_KEY,
+    EMAIL_BACKEND="anymail.backends.resend.EmailBackend",
+)
+class ResendBackendIntegrationTests(AnymailTestMixin, SimpleTestCase):
+    """Resend.com API integration tests
+
+    Resend doesn't have sandbox so these tests run
+    against the **live** Resend API, using the
+    environment variable `ANYMAIL_TEST_RESEND_API_KEY` as the API key,
+    and `ANYMAIL_TEST_RESEND_DOMAIN` to construct sender addresses.
+    If those variables are not set, these tests won't run.
+
+    """
+
+    def setUp(self):
+        super().setUp()
+        self.from_email = "from@%s" % ANYMAIL_TEST_RESEND_DOMAIN
+        self.message = AnymailMessage(
+            "Anymail Resend integration test",
+            "Text content",
+            self.from_email,
+            ["test+to1@anymail.dev"],
+        )
+        self.message.attach_alternative("<p>HTML content</p>", "text/html")
+
+    def test_simple_send(self):
+        # Example of getting the Resend message id from the message
+        sent_count = self.message.send()
+        self.assertEqual(sent_count, 1)
+
+        anymail_status = self.message.anymail_status
+        sent_status = anymail_status.recipients["test+to1@anymail.dev"].status
+        message_id = anymail_status.recipients["test+to1@anymail.dev"].message_id
+
+        self.assertEqual(sent_status, "queued")  # Resend always queues
+        self.assertGreater(len(message_id), 0)  # non-empty string
+        # set of all recipient statuses:
+        self.assertEqual(anymail_status.status, {sent_status})
+        self.assertEqual(anymail_status.message_id, message_id)
+
+    def test_all_options(self):
+        message = AnymailMessage(
+            subject="Anymail Resend all-options integration test",
+            body="This is the text body",
+            from_email=formataddr(("Test From, with comma", self.from_email)),
+            to=["test+to1@anymail.dev", '"Recipient 2, OK?" <test+to2@anymail.dev>'],
+            cc=["test+cc1@anymail.dev", "Copy 2 <test+cc2@anymail.dev>"],
+            bcc=["test+bcc1@anymail.dev", "Blind Copy 2 <test+bcc2@anymail.dev>"],
+            reply_to=['"Reply, with comma" <reply@example.com>', "reply2@example.com"],
+            headers={"X-Anymail-Test": "value", "X-Anymail-Count": 3},
+            metadata={"meta1": "simple string", "meta2": 2},
+            tags=["tag 1", "tag 2"],
+        )
+        message.attach_alternative("<p>HTML content</p>", "text/html")
+
+        message.attach("attachment1.txt", "Here is some\ntext for you", "text/plain")
+        message.attach("attachment2.csv", "ID,Name\n1,Amy Lina", "text/csv")
+
+        message.send()
+        # Resend always queues:
+        self.assertEqual(message.anymail_status.status, {"queued"})
+        self.assertGreater(
+            len(message.anymail_status.message_id), 0
+        )  # non-empty string
+
+    @override_settings(ANYMAIL_RESEND_API_KEY="Hey, that's not an API key!")
+    def test_invalid_api_key(self):
+        with self.assertRaisesMessage(AnymailAPIError, "API key is invalid"):
+            self.message.send()