diff --git a/nimble/controller/src/ble_ll_hci.c b/nimble/controller/src/ble_ll_hci.c
index 356869eee6..7175b62f9b 100644
--- a/nimble/controller/src/ble_ll_hci.c
+++ b/nimble/controller/src/ble_ll_hci.c
@@ -1503,7 +1503,8 @@ ble_ll_hci_ctlr_bb_cmd_proc(const uint8_t *cmdbuf, uint8_t len, uint16_t ocf,
     case BLE_HCI_OCF_CB_SET_EVENT_MASK2:
         rc = ble_ll_hci_cb_set_event_mask2(cmdbuf, len);
         break;
-#if MYNEWT_VAL(BLE_LL_CFG_FEAT_LE_PING)
+#if MYNEWT_VAL(BLE_LL_CFG_FEAT_LL_ENHANCED_CONN_UPDATE) && \
+        MYNEWT_VAL(BLE_LL_CFG_FEAT_LE_PING)
     case BLE_HCI_OCF_CB_RD_AUTH_PYLD_TMO:
         rc = ble_ll_conn_hci_rd_auth_pyld_tmo(cmdbuf, len, rspbuf, rsplen);
         break;
diff --git a/nimble/controller/syscfg.yml b/nimble/controller/syscfg.yml
index f125891744..079dd5d065 100644
--- a/nimble/controller/syscfg.yml
+++ b/nimble/controller/syscfg.yml
@@ -242,7 +242,7 @@ syscfg.defs:
         description: >
             This option enables/disables encryption support in the controller.
             This option saves both both code and RAM.
-        value: 'MYNEWT_VAL_BLE_LL_ROLE_CENTRAL || MYNEWT_VAL_BLE_LL_ROLE_PERIPHERAL'
+        value: 'MYNEWT_VAL_BLE_LL_ROLE_CENTRAL || MYNEWT_VAL_BLE_LL_ROLE_PERIPHERAL || MYNEWT_VAL_BLE_LL_ISO'
 
     BLE_LL_CFG_FEAT_CONN_PARAM_REQ:
         description: >
diff --git a/nimble/drivers/nrf5x/src/ble_phy.c b/nimble/drivers/nrf5x/src/ble_phy.c
index a4d47cef7b..ec5507c9fa 100644
--- a/nimble/drivers/nrf5x/src/ble_phy.c
+++ b/nimble/drivers/nrf5x/src/ble_phy.c
@@ -1527,7 +1527,7 @@ ble_phy_isr(void)
     os_trace_isr_exit();
 }
 
-#if PHY_USE_HEADERMASK_WORKAROUND
+#if PHY_USE_HEADERMASK_WORKAROUND && MYNEWT_VAL(BLE_LL_CFG_FEAT_LE_ENCRYPTION)
 static void
 ble_phy_ccm_isr(void)
 {