diff --git a/crate_universe/src/metadata/cargo_tree_resolver.rs b/crate_universe/src/metadata/cargo_tree_resolver.rs
index bdcfa2b31a..27c5c03155 100644
--- a/crate_universe/src/metadata/cargo_tree_resolver.rs
+++ b/crate_universe/src/metadata/cargo_tree_resolver.rs
@@ -150,6 +150,7 @@ impl TreeResolver {
                     // host triple instead of the host triple detected by rustc.
                     .env("RUSTC_WRAPPER", rustc_wrapper)
                     .env("HOST_TRIPLE", host_triple)
+                    .env("CARGO_CACHE_RUSTC_INFO", "0")
                     .current_dir(manifest_path.parent().expect("All manifests should have a valid parent."))
                     .arg("tree")
                     .arg("--manifest-path")
diff --git a/crate_universe/tests/cargo_integration_test.rs b/crate_universe/tests/cargo_integration_test.rs
index 49b739b8d2..d8bf4f1f51 100644
--- a/crate_universe/tests/cargo_integration_test.rs
+++ b/crate_universe/tests/cargo_integration_test.rs
@@ -526,16 +526,24 @@ fn host_specific_build_deps() {
     }
 
     let r = runfiles::Runfiles::create().unwrap();
+
+    let src_cargo_toml = runfiles::rlocation!(
+        r,
+        "rules_rust/crate_universe/test_data/metadata/host_specific_build_deps/Cargo.toml"
+    )
+    .unwrap();
+
+    // Put Cargo.toml into writable directory structure and create target/ directory to verify that
+    // cargo does not incorrectly cache rustc info in target/.rustc_info.json file.
+    let scratch = tempfile::tempdir().unwrap();
+    let cargo_toml = scratch.path().join("Cargo.toml");
+    fs::copy(src_cargo_toml, &cargo_toml).unwrap();
+    fs::create_dir(scratch.path().join("target")).unwrap();
+
     let metadata = run(
         "host_specific_build_deps",
         HashMap::from([(
-            runfiles::rlocation!(
-                r,
-                "rules_rust/crate_universe/test_data/metadata/host_specific_build_deps/Cargo.toml"
-            )
-            .unwrap()
-            .to_string_lossy()
-            .to_string(),
+            cargo_toml.to_string_lossy().to_string(),
             "//:test_input".to_string(),
         )]),
         "rules_rust/crate_universe/test_data/metadata/host_specific_build_deps/Cargo.lock",