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ClinicalPhenotype.txt
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ClinicalPhenotype.txt
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Level Molecular level
GO:0046785 microtubule polymerization
GO:0034205 amyloid-beta formation
GO:0001540 amyloid-beta binding
GO:0042982 amyloid precursor protein metabolicprocess
GO:0042984 regulation of amyloid precursor protein biosynthetic process
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
GO:0042986 positive regulation of amyloid precursor protein biosynthetic process
GO:0042987 amyloid precursor protein catabolicprocess
GO:0050435 amyloid-beta metabolic process
GO:0097242 amyloid-beta clearance
GO:0106003 amyloid-beta complex
GO:0150093 amyloid-beta clearance by transcytosis
GO:0150094 amyloid-beta clearance by cellular catabolic process
GO:1900221 regulation of amyloid-beta clearance
GO:1900222 negative regulation of amyloid-betaclearance
GO:1900223 positive regulation of amyloid-betaclearance
GO:1902003 regulation of amyloid-beta formation
GO:1902004 positive regulation of amyloid-betaformation
GO:1902430 negative regulation of amyloid-betaformation
GO:1902991 regulation of amyloid precursor protein catabolic process
GO:1902992 negative regulation of amyloid precursor protein catabolic process
GO:1902993 positive regulation of amyloid precursor protein catabolic process
GO:1904645 response to amyloid-beta
GO:1904646 cellular response to amyloid-beta
GO:1905906 regulation of amyloid fibril formation
GO:1905907 negative regulation of amyloid fibril formation
GO:1905908 positive regulation of amyloid fibril formation
GO:1990000 amyloid fibril formation
HP:0001917 Renal amyloidosis
HP:0003216 Generalized amyloid deposition
HP:0003791 Deposits immunoreactive to beta-amyloid protein
HP:0011970 Cerebral amyloid angiopathy
HP:0025683 Abnormal amyloid beta 42 peptide CSF concentration
HP:0025684 Decreased amyloid beta 42 peptide CSF concentration
HP:0025685 Increased amyloid beta 42 peptide CSF concentration
HP:0025686 Abnormal amyloid beta 40 peptide CSF concentration
HP:0025687 Increased amyloid beta 40 peptide CSF concentration
HP:0025688 Abnormal amyloid beta peptide CSF concentration
HP:0030843 Cardiac amyloidosis
HP:0030860 Abnormal CSF amyloid level
HP:0030861 Decreased CSF amyloid level
HP:0030862 Elevated CSF amyloid level
HP:4000041 AA amyloidosis
D000075363 Primary amyloidosis
GO:0006975 DNA damage induced protein phosphorylation
GO:0016310 phosphorylation
D010766 Phosphorylation
GO:0046785 microtubule polymerization
GO:0008017 microtubule binding
GO:0001578 microtubule bundle formation
GO:0030693 caspase activity
GO:0089720 caspase binding
Level Symptom level
GO:0006979 response to oxidative stress
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0036473 cell death in response to oxidativestress
GO:0036475 neuron death in response to oxidative stress
GO:0036480 neuron intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0043556 regulation of translation in response to oxidative stress
GO:1900407 regulation of cellular response to oxidative stress
GO:1900408 negative regulation of cellular response to oxidative stress
GO:1900409 positive regulation of cellular response to oxidative stress
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902882 regulation of response to oxidativestress
GO:1902883 negative regulation of response to oxidative stress
GO:1902884 positive regulation of response to oxidative stress
GO:1903201 regulation of oxidative stress-induced cell death
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903203 regulation of oxidative stress-induced neuron death
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:1903209 positive regulation of oxidative stress-induced cell death
GO:1903223 positive regulation of oxidative stress-induced neuron death
GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:0051402 neuron apoptotic process
GO:0070997 neuron death
GO:0043504 mitochondrial DNA repair
GO:1904124 microglial cell migration
GO:0001774 microglial cell activation
GO:0060785 regulation of apoptosis involved intissue homeostasis
GO:0097194 execution phase of apoptosis
GO:0006954 inflammatory response
GO:1900117 regulation of execution phase of apoptosis
GO:1900118 negative regulation of execution phase of apoptosis
GO:1900119 positive regulation of execution phase of apoptosis
HP:4000056 Abnormal apoptosis
GO:0097418 neurofibrillary tangle
GO:1902988 neurofibrillary tangle assembly
GO:1902996 regulation of neurofibrillary tangl assembly
GO:1902997 negative regulation of neurofibrillary tangle assembly
GO:1902998 positive regulation of neurofibrillary tangle assembly
GO:0150076 neuroinflammatory response
GO:0150077 regulation of neuroinflammatory response
GO:0150078 positive regulation of neuroinflammatory response
GO:0150079 negative regulation of neuroinflammatory response
HP:0100256 Senile plaques
Level Disease level
HP:0006956 Dilation of lateral ventricles
GO:0021801 cerebral cortex radial glia-guided migration
GO:0021987 cerebral cortex development
HP:0002538 Abnormal cerebral cortex morphology
HP:0006891 Thick cerebral cortex
HP:0007190 Neuronal loss in the cerebral cortex
HP:0010993 Abnormality of the cerebral subcortex
HP:0002180 Neurodegeneration
HP:0033687 Short term memory impairment
HP:0033688 Long term memory impairment
HP:0033689 Anterograde memory impairment
HP:0033690 Retrograde memory impairment
HP:0033691 Procedural memory loss
HP:0033692 Declarative memory loss
HP:0031466 Impairment in personality functioning