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Hello,
Is it possible to select only variants that are definitely inherited from parents, also taking into account alleles?
I tried with function below to control genotypes. But that function don't care for alleles, only genotypes. --trio "inherited:(mom.het && dad.het && kid.het) || (mom.hom_ref && dad.het && kid.het) || (mom.het && dad.hom_ref && kid.het) || (mom.het && dad.het && kid.hom_alt) || (mom.hom_alt && dad.hom_alt && kid.hom_alt) || (mom.hom_alt && dad.het && kid.hom_alt) || (mom.het && dad.hom_alt && kid.hom_alt)"
I found some cases with multialleles variants, for example: ref: CA alt: C,CAA GT: mom: 0/1, dad: 0/1, kid: 0/2
So it should be classified as de novo deletion not inherited variant.
Do you have maybe better solution?
Thanks.
The text was updated successfully, but these errors were encountered:
Hello,
Is it possible to select only variants that are definitely inherited from parents, also taking into account alleles?
I tried with function below to control genotypes. But that function don't care for alleles, only genotypes.
--trio "inherited:(mom.het && dad.het && kid.het) || (mom.hom_ref && dad.het && kid.het) || (mom.het && dad.hom_ref && kid.het) || (mom.het && dad.het && kid.hom_alt) || (mom.hom_alt && dad.hom_alt && kid.hom_alt) || (mom.hom_alt && dad.het && kid.hom_alt) || (mom.het && dad.hom_alt && kid.hom_alt)"
I found some cases with multialleles variants, for example:
ref: CA alt: C,CAA GT: mom: 0/1, dad: 0/1, kid: 0/2
So it should be classified as de novo deletion not inherited variant.
Do you have maybe better solution?
Thanks.
The text was updated successfully, but these errors were encountered: