diff --git a/.github/workflows/_bazel.yml b/.github/workflows/_bazel.yml
index 9e9c70b19f9..bc995974e86 100644
--- a/.github/workflows/_bazel.yml
+++ b/.github/workflows/_bazel.yml
@@ -5,7 +5,7 @@ on:
       image:
         type: string
         required: false
-        default: "ubuntu-20.04"
+        default: "ubuntu-22.04"
       os_name:
         type: string
         required: false
diff --git a/.github/workflows/npm-types.yml b/.github/workflows/npm-types.yml
index 66fb622622a..1f5b37bf0d9 100644
--- a/.github/workflows/npm-types.yml
+++ b/.github/workflows/npm-types.yml
@@ -30,7 +30,7 @@ jobs:
           echo "version=${{ inputs.prerelease == false && '4' || '0'}}.$(cat src/workerd/io/supported-compatibility-date.txt | tr -d '-').${{ inputs.patch }}" >> $GITHUB_OUTPUT;
           echo "release_version=1.$(cat src/workerd/io/supported-compatibility-date.txt | tr -d '-').0" >> $GITHUB_OUTPUT;
   build-and-publish-types:
-    runs-on: ubuntu-20.04
+    runs-on: ubuntu-22.04
     needs: version
     steps:
       - uses: actions/checkout@v4
diff --git a/.github/workflows/npm.yml b/.github/workflows/npm.yml
index 79c72a6f527..58152157451 100644
--- a/.github/workflows/npm.yml
+++ b/.github/workflows/npm.yml
@@ -75,7 +75,7 @@ jobs:
     # if: github.repository_owner == 'cloudflare'
     name: Publish `workerd` to NPM
     needs: [version, publish-arch-specific]
-    runs-on: ubuntu-20.04
+    runs-on: ubuntu-22.04
     steps:
       - name: Checkout Repo
         uses: actions/checkout@v4
diff --git a/.github/workflows/release-python-runtime.yml b/.github/workflows/release-python-runtime.yml
index 41c0df8b6d5..9d75513c945 100644
--- a/.github/workflows/release-python-runtime.yml
+++ b/.github/workflows/release-python-runtime.yml
@@ -12,7 +12,7 @@ on:
 
 jobs:
   build:
-    runs-on: ubuntu-20.04
+    runs-on: ubuntu-22.04
     name: build Python runtime
     steps:
       - uses: actions/checkout@v4
diff --git a/.github/workflows/release.yml b/.github/workflows/release.yml
index e2e17147b0c..f513ee8c869 100644
--- a/.github/workflows/release.yml
+++ b/.github/workflows/release.yml
@@ -10,7 +10,7 @@ jobs:
     outputs:
       version: ${{ steps.echo.outputs.version }}
     # version job uses ubuntu 24.04, this way we don't have to install the updated clang while
-    # the build job uses 20.04 for libc compatibility.
+    # the build job uses 22.04 for libc compatibility.
     runs-on: ubuntu-24.04
     steps:
       - uses: actions/checkout@v4
@@ -56,11 +56,11 @@ jobs:
   build:
     strategy:
       matrix:
-        os: [ubuntu-20.04, macos-15, windows-2022]
+        os: [ubuntu-22.04, macos-15, windows-2022]
         target-arch: [ X64 ]
         include:
           - os-name: linux
-            os: ubuntu-20.04
+            os: ubuntu-22.04
             bazel-config: release_linux
           # Based on runner availability, we build both Apple Silicon and (cross-compiled) x86
           # release binaries on the macos-15 runner.
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index bcfae5feca4..25873e5f777 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -27,7 +27,7 @@ jobs:
       matrix:
         os:
           [
-            { name : linux, image : ubuntu-20.04 },
+            { name : linux, image : ubuntu-22.04 },
             { name : macOS, image : macos-15 },
             { name : windows, image : windows-2022 }
           ]
@@ -40,7 +40,7 @@ jobs:
           ]
         include:
           # Add an Address Sanitizer (ASAN) build on Linux for additional checking.
-          - os:     { name: linux, image: ubuntu-20.04 }
+          - os:     { name: linux, image: ubuntu-22.04 }
             config: { suffix: -asan }
           # Windows has a custom non-debug bazel config.
           - os:     { name : windows, image : windows-2022 }
diff --git a/.github/workflows/type-snapshot.yml b/.github/workflows/type-snapshot.yml
index 4b14e204240..4d1143b7c40 100644
--- a/.github/workflows/type-snapshot.yml
+++ b/.github/workflows/type-snapshot.yml
@@ -16,7 +16,7 @@ concurrency:
 
 jobs:
   check-snapshot:
-    runs-on: ubuntu-20.04
+    runs-on: ubuntu-22.04
     steps:
       - uses: actions/checkout@v4
         with:
diff --git a/README.md b/README.md
index 606af88ba62..fb2b7d5d08c 100644
--- a/README.md
+++ b/README.md
@@ -178,7 +178,7 @@ For more details about command-line usage, use `workerd --help`.
 Prebuilt binaries are distributed via `npm`. Run `npx workerd ...` to use these. If you're running a prebuilt binary, you'll need to make sure your system has the right dependencies installed:
 
 * On Linux:
-  * glibc 2.31 or higher (already included on e.g. Ubuntu 20.04, Debian Bullseye)
+  * glibc 2.35 or higher (already included on e.g. Ubuntu 22.04, Debian Bookworm)
 * On macOS:
   * macOS 13.5 or higher
   * The Xcode command line tools, which can be installed with `xcode-select --install`