diff --git a/CHANGELOG.adoc b/CHANGELOG.adoc
index bde2eaa9e7..3a8a8ee40d 100644
--- a/CHANGELOG.adoc
+++ b/CHANGELOG.adoc
@@ -31,7 +31,7 @@ The `start` task used in our turbo configuration is now marked as `persistent` a
 
 === Improvements
 
-
+- https://github.com/eclipse-sirius/sirius-web/issues/4345[#4345] [table] Make table cells independently selectable
 
 == v2025.1.0
 
diff --git a/packages/tables/frontend/sirius-components-tables/src/table/TableContent.tsx b/packages/tables/frontend/sirius-components-tables/src/table/TableContent.tsx
index c85bf29492..c5131a3c14 100644
--- a/packages/tables/frontend/sirius-components-tables/src/table/TableContent.tsx
+++ b/packages/tables/frontend/sirius-components-tables/src/table/TableContent.tsx
@@ -1,5 +1,5 @@
 /*******************************************************************************
- * Copyright (c) 2024 Obeo.
+ * Copyright (c) 2024, 2025 Obeo.
  * This program and the accompanying materials
  * are made available under the terms of the Eclipse Public License v2.0
  * which accompanies this distribution, and is available at
@@ -12,6 +12,7 @@
  *******************************************************************************/
 import { Selection, useSelection } from '@eclipse-sirius/sirius-components-core';
 import Box from '@mui/material/Box';
+import { Theme, useTheme } from '@mui/material/styles';
 import { MaterialReactTable, MRT_DensityState, MRT_TableOptions, useMaterialReactTable } from 'material-react-table';
 import { memo, useEffect, useState } from 'react';
 import { SettingsButton } from '../actions/SettingsButton';
@@ -43,6 +44,7 @@ export const TableContent = memo(
     enablePagination,
   }: TableProps) => {
     const { selection, setSelection } = useSelection();
+    const theme: Theme = useTheme();
 
     const { columns } = useTableColumns(
       editingContextId,
@@ -165,10 +167,6 @@ export const TableContent = memo(
       state: { columnSizing, columnVisibility, globalFilter, density, columnFilters },
       muiTableBodyRowProps: ({ row }) => {
         return {
-          onClick: () => {
-            const newSelection: Selection = { entries: [{ id: row.original.targetObjectId, kind: 'Object' }] };
-            setSelection(newSelection);
-          },
           selected: selection.entries.map((entry) => entry.id).includes(row.original.targetObjectId),
           sx: {
             backgroundColor: 'transparent', // required to remove the default mui backgroundColor that is defined as !important
@@ -177,6 +175,19 @@ export const TableContent = memo(
           },
         };
       },
+      muiTableBodyCellProps: ({ cell, row }) => {
+        const rowSelected = selection.entries.map((entry) => entry.id).includes(row.original.targetObjectId);
+        const cellTargetObjectId = row.original.cells.find(
+          (originalCell) => originalCell.columnId === cell.column.id
+        )?.targetObjectId;
+        const cellSelected =
+          cellTargetObjectId && selection.entries.map((entry) => entry.id).includes(cellTargetObjectId);
+        return {
+          sx: {
+            border: !rowSelected && cellSelected ? `2px dashed ${theme.palette.action.selected}` : undefined,
+          },
+        };
+      },
       renderTopToolbarCustomActions: () => (
         <Box>
           <SettingsButton editingContextId={editingContextId} representationId={representationId} table={table} />
@@ -200,7 +211,18 @@ export const TableContent = memo(
         },
       },
       renderRowActions: ({ row }) => (
-        <>
+        <div
+          onClick={() => {
+            const newSelection: Selection = {
+              entries: [
+                {
+                  id: row.original.targetObjectId,
+                  kind: row.original.targetObjectKind,
+                },
+              ],
+            };
+            setSelection(newSelection);
+          }}>
           <RowHeader row={row.original} />
           {enableRowSizing ? (
             <ResizeRowHandler
@@ -212,7 +234,7 @@ export const TableContent = memo(
               onRowHeightChanged={handleRowHeightChange}
             />
           ) : null}
-        </>
+        </div>
       ),
     };
 
diff --git a/packages/tables/frontend/sirius-components-tables/src/table/TableContent.types.ts b/packages/tables/frontend/sirius-components-tables/src/table/TableContent.types.ts
index b7259cd642..a189ad202d 100644
--- a/packages/tables/frontend/sirius-components-tables/src/table/TableContent.types.ts
+++ b/packages/tables/frontend/sirius-components-tables/src/table/TableContent.types.ts
@@ -1,5 +1,5 @@
 /*******************************************************************************
- * Copyright (c) 2024 Obeo.
+ * Copyright (c) 2024, 2025 Obeo.
  * This program and the accompanying materials
  * are made available under the terms of the Eclipse Public License v2.0
  * which accompanies this distribution, and is available at
@@ -86,6 +86,7 @@ export interface GQLColumn {
 export interface GQLLine {
   id: string;
   targetObjectId: string;
+  targetObjectKind: string;
   cells: GQLCell[];
   headerLabel: string;
   headerIconURLs: string[];
@@ -104,6 +105,8 @@ export interface GQLCell {
   __typename: string;
   id: string;
   columnId: string;
+  targetObjectId: string;
+  targetObjectKind: string;
 }
 
 export interface GQLTextfieldCell extends GQLCell {
diff --git a/packages/tables/frontend/sirius-components-tables/src/table/useTableColumns.tsx b/packages/tables/frontend/sirius-components-tables/src/table/useTableColumns.tsx
index f1b2e09a1e..a7dd6e5847 100644
--- a/packages/tables/frontend/sirius-components-tables/src/table/useTableColumns.tsx
+++ b/packages/tables/frontend/sirius-components-tables/src/table/useTableColumns.tsx
@@ -1,5 +1,5 @@
 /*******************************************************************************
- * Copyright (c) 2024 Obeo.
+ * Copyright (c) 2024, 2025 Obeo.
  * This program and the accompanying materials
  * are made available under the terms of the Eclipse Public License v2.0
  * which accompanies this distribution, and is available at
@@ -10,13 +10,21 @@
  * Contributors:
  *     Obeo - initial API and implementation
  *******************************************************************************/
+import { Selection, useSelection } from '@eclipse-sirius/sirius-components-core';
 import { MRT_ColumnDef } from 'material-react-table';
 import { useMemo } from 'react';
+import { makeStyles } from 'tss-react/mui';
 import { Cell } from '../cells/Cell';
 import { ColumnHeader } from '../columns/ColumnHeader';
 import { GQLCell, GQLLine, GQLTable } from './TableContent.types';
 import { UseTableColumnsValue } from './useTableColumns.types';
 
+const useStyles = makeStyles()(() => ({
+  cell: {
+    width: '100%',
+  },
+}));
+
 export const useTableColumns = (
   editingContextId: string,
   representationId: string,
@@ -26,6 +34,8 @@ export const useTableColumns = (
   enableColumnSizing: boolean,
   enableColumnFilters: boolean
 ): UseTableColumnsValue => {
+  const { classes } = useStyles();
+  const { setSelection } = useSelection();
   const columns = useMemo<MRT_ColumnDef<GQLLine, string>[]>(() => {
     const columnDefs: MRT_ColumnDef<GQLLine, string>[] = table.columns.map((column) => {
       return {
@@ -41,14 +51,22 @@ export const useTableColumns = (
         visibleInShowHideMenu: enableColumnVisibility,
         Cell: ({ row }) => {
           const cell: GQLCell | null = row.original.cells.find((cell) => column.id === cell.columnId) ?? null;
+          const onClick = () => {
+            if (cell) {
+              const newSelection: Selection = { entries: [{ id: cell.targetObjectId, kind: cell.targetObjectKind }] };
+              setSelection(newSelection);
+            }
+          };
           return (
-            <Cell
-              editingContextId={editingContextId}
-              representationId={representationId}
-              tableId={table.id}
-              cell={cell}
-              disabled={readOnly}
-            />
+            <div className={classes.cell} onClick={onClick}>
+              <Cell
+                editingContextId={editingContextId}
+                representationId={representationId}
+                tableId={table.id}
+                cell={cell}
+                disabled={readOnly}
+              />
+            </div>
           );
         },
       };