diff --git a/spack/packages/sirius/package.py b/spack/packages/sirius/package.py
index 0e1e6203f..383fe2b72 100644
--- a/spack/packages/sirius/package.py
+++ b/spack/packages/sirius/package.py
@@ -102,7 +102,7 @@ class Sirius(CMakePackage, CudaPackage, ROCmPackage):
         "profiler", default=True, description="Use internal profiler to measure execution time"
     )
     variant(
-        "nvtx", default=False, description="Use NVTX profiler"
+        "nvtx", default=False, description="Use NVTX/ROCTX profiler"
     )
 
     depends_on("cmake@3.23:", type="build")
@@ -147,6 +147,7 @@ class Sirius(CMakePackage, CudaPackage, ROCmPackage):
     depends_on("nlcglib+cuda", when="+nlcglib+cuda")
 
     depends_on("libvdwxc@0.3.0:+mpi", when="+vdwxc")
+    depends_on("roctracer-dev", when="+nvtx+rocm")
 
     depends_on("scalapack", when="+scalapack")
 
@@ -165,6 +166,7 @@ class Sirius(CMakePackage, CudaPackage, ROCmPackage):
     conflicts("^libxc@5.0.0")  # known to produce incorrect results
     conflicts("+single_precision", when="@:7.2.4")
     conflicts("+scalapack", when="^cray-libsci")
+    conflicts("+nvtx", when="~cuda~rocm")
 
     # Propagate openmp to blas
     depends_on("openblas threads=openmp", when="+openmp ^openblas")