From b4dd94a275b8ece7e7422733d9577caed982b585 Mon Sep 17 00:00:00 2001 From: Raymond Lee Date: Wed, 11 Sep 2024 15:21:06 -0700 Subject: [PATCH] Revised 5 definitions; fixes #28762 --- src/ontology/go-edit.obo | 13 ++++++++----- 1 file changed, 8 insertions(+), 5 deletions(-) diff --git a/src/ontology/go-edit.obo b/src/ontology/go-edit.obo index a8ebbdaaec..f78db657d5 100644 --- a/src/ontology/go-edit.obo +++ b/src/ontology/go-edit.obo @@ -79292,7 +79292,7 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i id: GO:0008467 name: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity namespace: molecular_function -def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23] +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(heparan sulfate)(n) = 3-sulfo-alpha-D-glucosaminyl-(heparan sulfate)(n) + adenosine 3',5'-bisphosphate + H+. The (heparan sulfate)-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase" BROAD [EC:2.8.2.23] synonym: "3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity" RELATED [EC:2.8.2.23] synonym: "3-OST-1 activity" RELATED [EC:2.8.2.23] @@ -79303,6 +79303,7 @@ synonym: "heparin-glucosamine 3-O-sulphotransferase activity" RELATED [] synonym: "isoform/isozyme 1 (3-OST-1, HS3ST1)" RELATED [EC:2.8.2.23] xref: EC:2.8.2.23 xref: MetaCyc:2.8.2.23-RXN +xref: RHEA:15461 {source="skos:broadMatch"} is_a: GO:0034483 ! heparan sulfate sulfotransferase activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28762" xsd:anyURI @@ -127882,7 +127883,7 @@ replaced_by: GO:0008236 id: GO:0017095 name: heparan sulfate 6-O-sulfotransferase activity namespace: molecular_function -def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate." [PMID:8631808] +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(heparan sulfate)(n) = 6-sulfo-alpha-D-glucosaminyl-(heparan sulfate)(n) + adenosine 3',5'-bisphosphate + H+." [PMID:8631808] synonym: "heparan sulphate 6-O-sulphotransferase activity" EXACT [] synonym: "heparin 6-O-sulfotransferase activity" RELATED [] is_a: GO:0034483 ! heparan sulfate sulfotransferase activity @@ -198126,7 +198127,7 @@ is_a: GO:0008146 ! sulfotransferase activity id: GO:0033871 name: [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity namespace: molecular_function -def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S." [EC:2.8.2.29] +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(heparan sulfate)(n) = 3-sulfo-alpha-D-glucosaminyl-(heparan sulfate)(n) + adenosine 3',5'-bisphosphate + H+. Modifies selected glucosamine residues preceded by GlcA2S." [EC:2.8.2.29] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.29] synonym: "3-OST-2" RELATED [EC:2.8.2.29] synonym: "glucosaminyl 3-O-sulfotransferase 2 activity" RELATED [EC:2.8.2.29] @@ -198137,6 +198138,7 @@ synonym: "heparin-glucosamine 3-sulfotransferase 2 activity" RELATED [] synonym: "isoform/isozyme 2 (3-OST-2, HS3ST2)" RELATED [EC:2.8.2.29] xref: EC:2.8.2.29 xref: MetaCyc:2.8.2.29-RXN +xref: RHEA:15461 {source="skos:broadMatch"} is_a: GO:0034483 ! heparan sulfate sulfotransferase activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28762" xsd:anyURI @@ -198144,7 +198146,7 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i id: GO:0033872 name: [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity namespace: molecular_function -def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate." [EC:2.8.2.30] +def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(heparan sulfate)(n) = 3-sulfo-alpha-D-glucosaminyl-(heparan sulfate)(n) + adenosine 3',5'-bisphosphate + H+." [EC:2.8.2.30] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity" BROAD [EC:2.8.2.30] synonym: "3-OST-3" RELATED [EC:2.8.2.30] synonym: "glucosaminyl 3-O-sulfotransferase 3 activity" RELATED [EC:2.8.2.30] @@ -198155,6 +198157,7 @@ synonym: "heparin-glucosamine 3-sulfotransferase 3 activity" RELATED [] synonym: "isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B)" RELATED [EC:2.8.2.30] xref: EC:2.8.2.30 xref: MetaCyc:2.8.2.30-RXN +xref: RHEA:15461 {source="skos:broadMatch"} is_a: GO:0034483 ! heparan sulfate sulfotransferase activity property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/28762" xsd:anyURI @@ -290779,7 +290782,7 @@ is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and de id: GO:0047464 name: heparosan-N-sulfate-glucuronate 5-epimerase activity namespace: molecular_function -def: "Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN] +def: "Catalysis of the reaction: (heparosan-N-sulfate)(n) = (heparan-N-sulfate)(n). Converts D-glucosyluronate residues to L-iduronate residues." [EC:5.1.3.17, MetaCyc:5.1.3.17-RXN] synonym: "C-5 uronosyl epimerase activity" RELATED [EC:5.1.3.17] synonym: "D-glucuronyl C-5 epimerase activity" RELATED [EC:5.1.3.17] synonym: "heparosan epimerase activity" RELATED [EC:5.1.3.17]