diff --git a/MIGRATION_GUIDE.md b/MIGRATION_GUIDE.md
index 168de1cfcb..e2f3dd8803 100644
--- a/MIGRATION_GUIDE.md
+++ b/MIGRATION_GUIDE.md
@@ -11,6 +11,7 @@ Looking to upgrade from Sentry SDK 2.x to 3.x? Here's a comprehensive list of wh
 - The SDK now supports Python 3.7 and higher.
 - `sentry_sdk.start_span` now only takes keyword arguments.
 - `sentry_sdk.start_transaction`/`sentry_sdk.start_span` no longer takes the following arguments: `span`, `parent_sampled`, `trace_id`, `span_id` or `parent_span_id`.
+- You can no longer change the sampled status of a span with `span.sampled = False` after starting it.
 - The `Span()` constructor does not accept a `hub` parameter anymore.
 - `Span.finish()` does not accept a `hub` parameter anymore.
 - The `Profile()` constructor does not accept a `hub` parameter anymore.
diff --git a/sentry_sdk/integrations/sanic.py b/sentry_sdk/integrations/sanic.py
index 7b49f5eaf3..0854c3dbee 100644
--- a/sentry_sdk/integrations/sanic.py
+++ b/sentry_sdk/integrations/sanic.py
@@ -187,8 +187,11 @@ async def _context_enter(request):
         return
 
     weak_request = weakref.ref(request)
-    request.ctx._sentry_scope = sentry_sdk.isolation_scope()
-    scope = request.ctx._sentry_scope.__enter__()
+    request.ctx._sentry_scope_manager = sentry_sdk.isolation_scope()
+    scope = request.ctx._sentry_scope_manager.__enter__()
+    request.ctx._sentry_scope = scope
+
+    scope.set_transaction_name(request.path, TRANSACTION_SOURCE_URL)
     scope.clear_breadcrumbs()
     scope.add_event_processor(_make_request_processor(weak_request))
 
@@ -197,7 +200,7 @@ async def _context_enter(request):
         dict(request.headers)
     )
     request.ctx._sentry_continue_trace.__enter__()
-    request.ctx._sentry_transaction = sentry_sdk.start_transaction(
+    request.ctx._sentry_transaction = sentry_sdk.start_span(
         op=OP.HTTP_SERVER,
         # Unless the request results in a 404 error, the name and source will get overwritten in _set_transaction
         name=request.path,
@@ -220,14 +223,20 @@ async def _context_exit(request, response=None):
         # happens while trying to end the transaction, we still attempt to exit the scope.
         with capture_internal_exceptions():
             request.ctx._sentry_transaction.set_http_status(response_status)
-            request.ctx._sentry_transaction.sampled &= (
+
+            if (
                 isinstance(integration, SanicIntegration)
-                and response_status not in integration._unsampled_statuses
-            )
+                and response_status in integration._unsampled_statuses
+            ):
+                # drop the event in an event processor
+                request.ctx._sentry_scope.add_event_processor(
+                    lambda _event, _hint: None
+                )
+
             request.ctx._sentry_transaction.__exit__(None, None, None)
             request.ctx._sentry_continue_trace.__exit__(None, None, None)
 
-        request.ctx._sentry_scope.__exit__(None, None, None)
+        request.ctx._sentry_scope_manager.__exit__(None, None, None)
 
 
 async def _set_transaction(request, route, **_):
diff --git a/sentry_sdk/tracing.py b/sentry_sdk/tracing.py
index 6d24f4d10a..59971e274e 100644
--- a/sentry_sdk/tracing.py
+++ b/sentry_sdk/tracing.py
@@ -1231,7 +1231,9 @@ def __init__(
             skip_span = False
             if only_if_parent:
                 parent_span_context = get_current_span().get_span_context()
-                skip_span = not parent_span_context.is_valid or parent_span_context.is_remote
+                skip_span = (
+                    not parent_span_context.is_valid or parent_span_context.is_remote
+                )
 
             if skip_span:
                 self._otel_span = INVALID_SPAN
@@ -1401,11 +1403,6 @@ def sampled(self):
         # type: () -> Optional[bool]
         return self._otel_span.get_span_context().trace_flags.sampled
 
-    @sampled.setter
-    def sampled(self, value):
-        # type: (Optional[bool]) -> None
-        pass
-
     @property
     def op(self):
         # type: () -> Optional[str]
diff --git a/tests/integrations/sanic/test_sanic.py b/tests/integrations/sanic/test_sanic.py
index 9d95907144..a3fc5a7652 100644
--- a/tests/integrations/sanic/test_sanic.py
+++ b/tests/integrations/sanic/test_sanic.py
@@ -346,8 +346,9 @@ def __init__(
         expected_status,
         expected_transaction_name,
         expected_source=None,
+        has_transaction_event=True,
     ):
-        # type: (Iterable[Optional[Container[int]]], str, int, Optional[str], Optional[str]) -> None
+        # type: (Iterable[Optional[Container[int]]], str, int, Optional[str], Optional[str], bool) -> None
         """
         expected_transaction_name of None indicates we expect to not receive a transaction
         """
@@ -356,6 +357,7 @@ def __init__(
         self.expected_status = expected_status
         self.expected_transaction_name = expected_transaction_name
         self.expected_source = expected_source
+        self.has_transaction_event = has_transaction_event
 
 
 @pytest.mark.skipif(
@@ -386,6 +388,7 @@ def __init__(
             url="/404",
             expected_status=404,
             expected_transaction_name=None,
+            has_transaction_event=False,
         ),
         TransactionTestConfig(
             # With no ignored HTTP statuses, we should get transactions for 404 errors
@@ -401,6 +404,7 @@ def __init__(
             url="/message",
             expected_status=200,
             expected_transaction_name=None,
+            has_transaction_event=False,
         ),
     ],
 )
@@ -430,9 +434,7 @@ def test_transactions(test_config, sentry_init, app, capture_events):
     (transaction_event, *_) = [*transaction_events, None]
 
     # We should have no transaction event if and only if we expect no transactions
-    assert (transaction_event is None) == (
-        test_config.expected_transaction_name is None
-    )
+    assert bool(transaction_event) == test_config.has_transaction_event
 
     # If a transaction was expected, ensure it is correct
     assert (