Code required to run PUFFIN can be found at https://github.com/gifford-lab/PUFFIN. Details relating to the dataset used to train PUFFIN can be found at https://github.com/birnbaumlab/Rappazzo-et-al-2020. New deep sequencing data are deposited on the NCBI Sequence Read Archive (SRA) with accession code PRJNA708266 (https://www.ncbi.nlm.nih.gov/bioproject/PRJNA708266).