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Gaelle Letort edited this page Dec 13, 2017 · 22 revisions

Presentation

PhysiBoSS (PhysiCell-MaBoSS) is adapted version of PhysiCell (see physicell.mathcancer.org ) to integrate in it boolean network computation inside each cell. PhysiCell is developped in Paul Macklin's lab (mathcancer.org). MaBoSS and PhysiBoSS are developped in the Computational Systems Biology of Cancer group (sysbio.curie.fr)
Code is written in C++ and open-source. In PhysiCell, there are two main part: BioFVM part which handle the diffusion/production of molecules (e.g. oxygen) and the PhysiCell part that handle the cells themselves. A cell can have a "classic" implementation of the cell cycle (adapted from PhysiCell1.0 initial implementation), or a cell cycling mode determined by a boolean network assigned to each individual cell (using MaBoSS). Could be easily adapted to other network or implementation.


![PhysiCell-MaBoSS example](https://github.com/gletort/PhysiBoSS/doc/imgs/hello.png)


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