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PhysiBoSS
(PhysiCell-MaBoSS) is adapted version of PhysiCell
(see physicell.mathcancer.org ) to integrate in it boolean network computation inside each cell. PhysiCell
is developped in Paul Macklin's lab (mathcancer.org). MaBoSS
and PhysiBoSS
are developped in the Computational Systems Biology of Cancer group (sysbio.curie.fr)
Code is written in C++
and open-source. In PhysiCell
, there are two main part: BioFVM
part which handle the diffusion/production of molecules (e.g. oxygen) and the PhysiCell
part that handle the cells themselves. A cell can have a "classic" implementation of the cell cycle (adapted from PhysiCell1.0
initial implementation), or a cell cycling mode determined by a boolean network assigned to each individual cell (using MaBoSS
). Could be easily adapted to other network or implementation.