ecosystem.md

Ecosystem

Heta supporting tools

• Julia package for simulation of large scale QSP models supporting Heta syntax: HetaSimulator.jl
• Command line tool compiling Heta and JS package: heta-compiler
• Syntax highlighting for VSCode: heta-highlight-vscode
• Syntax highlighting for Sublime text: heta-highlight-sublime
• Parsing of Heta language code in JavaScript: heta-parser

Web applications

Heta syntax and Heta infrastructure were utilized for the development of web-based tools.

• Heta API A public API for Heta language compilation.
• Heta compiler online Web based compiler and editor of Heta code.
• SbmlViewer A tool for fast and easy reading of biological models written in SBML format. It allows you to open SBML in any browser.
• Immune Response Template A Quantitative Systems Pharmacology (QSP) platform of immune system and tool for development of QSP and mechanistic models related to immune response.
• mAb-app PK/RO simulator for anti-PD-1 monoclonal Antibodies (Shiny app)
• ery PK/PD simulator for Erythropoiesis-Stimulating Agents (Shiny app)
• sbml-mrgsolve-case An RMarkdown example demonstrating format conversion from SBML into mrgsolve

Open source QSP platforms

The examples of Heta-based QSP platforms with CI/CD capabilities are shared on GitHub.

• heta-case-mini A demo example of QSP platform developed in the framework of Heta.
• insulin-signaling-t2d Dynamic notebooks for QSP usage case: Insulin Signaling in Type 2 Diabetes
• FAAH inhibitor model A platform describing Fatty Acid Amide Hydrolase inhibition in human.
• Drug Loaded Nanoparticles PBPK Modeling For Therapeutic Nanoparticles Loaded With Drug.
• COVID-19 QSP model QSP model describing SARS-CoV-2 virus and host cell life cycles, immune response and therapeutic treatments
• Alcohol PK Simple model of alcohol PK build on published data
• ANT model Adenine Nucleotide Translocase model reproduces from published resources

QSP projects

The Heta language and Heta-based QSP framework were used in several “real world” projects for the development of middle-scale and large-scale models.

Recommended Software for Working with Heta Models

To get started with Heta-based platforms, we recommend installing a minimal set of tools for full functionality. This setup ensures an efficient workflow, especially for medium- to large-scale QSP platforms. Usage of an Integrated Development Environment (IDE) is optional but highly beneficial.

For a guided introduction, check out the Heta tutorial's Lesson #1.

Minimal Recommended Setup

1. VSCode

   • Download and Install: https://code.visualstudio.com/
   • Install with extensions manager: Heta Highlight Plugin

2. heta-compiler

   • Installation Guide: https://hetalang.github.io/#/heta-compiler/?id=installation

3. HetaSimulator

   • Install Julia: https://julialang.org/downloads/
   • Install the package: https://hetalang.github.io/#/HetaSimulator.jl/

4. Git (optional)

   • Download: https://git-scm.com/
   • Provides Bash console and Git synchronization for version control.

Alternative Configuration

If you prefer, you can use Sublime Text instead of VSCode:

• Download and install: https://www.sublimetext.com/download
• Install the Heta highlighter plugin via:
  • Open Package Control > Install Package > Search for Heta.