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Add module for Progeny #14

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grst opened this issue Nov 17, 2021 · 0 comments
Open

Add module for Progeny #14

grst opened this issue Nov 17, 2021 · 0 comments
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@grst
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grst commented Nov 17, 2021

Progeny is a method for detecting enrichment of cancer pathways based on gene signatures

Input:

  • sample sheet
  • gene expression matrix

Output:

  • Plot
  • Table

I'm not sure if Progeny does proper statistical tests by group. If not, perform a simple statistical test, e.g. using a linear model.

Since it does not make sense to run Progeny on all datasets, this should be made optional (e.g. params.run_dorothea) and
be disabled by default.

@chripla chripla self-assigned this Dec 7, 2021
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