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Enhanced sampling molecular dynamics on HPC systems

Instructor/Author

Wei-Tse Hsu

If you're interested, check my personal website for more future posts/tutorials about advanced sampling methods!

Videos

Part 1

  • Lecture Segment 1: Introduction to High-Performing Computing (HPC) systems
  • Exercise 1: Performing multiple independent MD simulations in parallel
  • Lecture Segment 2: Introduction to umbrella sampling
  • Exercise 2, Umbrella sampling (part 1, pulling simulation)
  • Exercise 2, Umbrella sampling (part 2, production run)

Part 2

  • Lecture Segment 3: Introduction to multiple walkers metadynamics:
  • Exercise 3: Multiple walkers metadynamics:
  • Lecture Segment 4: Introduction to temperature and Hamiltonian replica exchange

Part 3

  • Exercise 4: Hamiltonian replica exchange
  • Lecture Segment 5: Introduction to other replica exchange methods and hybrid methods
  • Exercise 5: Replica exchange umbrella sampling
  • Lecture 6: Segment Even more replica exchange or hybrid methods

Outline

Here is the outline of this session, which alternatives between lecture sections (presented with the slides here) and hands-on exercises:

  • Introduction to High-Performing Computing (HPC) systems (pages 1 and 2 in the slides)
  • Exercise 1: Performing decoupled MD simulations in parallel
  • Introduction to umbrella sampling (pages 3 and 4 in the slides)
  • Exercise 2: Umbrella sampling
  • Introduction to multiple walkers metadynamics (page 5 in the slides)
  • Exercise 3: Multiple walkers metadynamics
  • Introduction to temperature and Hamiltonian replica exchange (pages 6 to 8 in the slides)
  • Exercise 4: Hamiltonian replica exchange
  • Introduction to other replica exchange methods and hybrid methods (pages 9 and 10 in the slides)
  • Exercise 5: Replica exchange umbrella sampling