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NEWS.md

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Version 1.0.2

  • Streamlined and simplified the summary statistic-based allelic series baseline and sum tests, removing the need for meta-analysis or estimating cross category correlations.

Version 1.0.0

  • Added ability to run COAST starting from summary statistics:
    • ASBTSS runs the allelic series burden test from summary statistics.
    • ASKATSS runs the allelic series SKAT test from summary statistics.
    • COASTSS runs the omnibus coding-variant allelic series test from summary statistics.
  • Added a CalcSumstats function to generate summary statistics from individual-level data.

Version 0.6.0

  • Replaced the CountAlleles function with a similar (but faster) Counts function that returns counts the total number of alleles, variants, and carriers by variant class.
  • Updated the formatting of the results output by the main COAST function.

Version 0.5.0

  • Added option (min_mac) to filter the variant set to only include those variants having at least a minimum minor allele count (10 is recommended).
  • Added a function (CountAlleles) to count the number of alleles of each variant category present in the genotype matrix. Also allows for counting the number of carriers of each type of allele.
  • By default, COAST now reports the number of alleles of each variant category that contributed to the test.