diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
new file mode 100644
index 0000000..35695fd
--- /dev/null
+++ b/.github/workflows/build.yml
@@ -0,0 +1,32 @@
+name: build
+
+on:
+  push:
+  pull_request:
+  schedule:
+  - cron: "3 3 * * 0"  # Run at a random time weekly
+
+jobs:
+  build:
+
+    strategy:
+      fail-fast: false
+      matrix:
+        os: [ubuntu-latest]
+        python-version: ["3.10"]
+    runs-on: ${{ matrix.os }}
+
+    steps:
+    - uses: actions/checkout@v2
+      with:
+        submodules: true
+    - name: Setup conda and dependencies
+      run: |
+        util/setup_ci.sh ${{ matrix.python-version }}
+    - name: Test
+      run: |
+        eval "$(conda shell.bash hook)"
+        conda activate python${{ matrix.python-version }}
+        cd test
+        # Run a quick subset of all tests
+        python test.py Tests.test_mmcif
diff --git a/util/setup_ci.sh b/util/setup_ci.sh
new file mode 100755
index 0000000..371a536
--- /dev/null
+++ b/util/setup_ci.sh
@@ -0,0 +1,20 @@
+#!/bin/bash -e
+
+# Set up an environment to run tests under Travis CI (see toplevel .travis.yml)
+# or GitHub Actions (see toplevel .github/workflows/build.yml)
+
+if [ $# -ne 1 ]; then
+  echo "Usage: $0 python_version"
+  exit 1
+fi
+
+python_version=$1
+
+# get conda-forge, not main, packages
+conda config --remove channels defaults
+conda config --add channels conda-forge
+IMP_CONDA="imp"
+
+conda create --yes -q -n python${python_version} -c salilab python=${python_version} matplotlib ${IMP_CONDA}
+eval "$(conda shell.bash hook)"
+conda activate python${python_version}