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run155.lst
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run155.lst
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Sat Feb 22 18:32:39 CST 2014
;; 1. Based on: run154
;; 2. Description: Good IV+IG, Three dose, CL, BIO, 7 CMTs
;; x1. Author: user
$PROBLEM METABOLISM OF ARCTIGENIN IN RATS AFTER IV AND IG - ADVAN6
$INPUT ID TIME DV DOSE=AMT MDV CMT EVID DL RTE
$DATA Arctigenin_IG+IV_for_nonmem.csv IGNORE=@
$SUBROUTINE ADVAN6 TRANS1 TOL=9
$MODEL COMP=(LUMEN DEFDOSE) ; 1. intestine lumen
COMP=(AR_CENTR) ; 2. AR in central
COMP=(AG_CENTR) ; 3. AG in central
COMP=(AA_CENTR) ; 4. AA in Central
COMP=(AR_INTES) ; 5. AR in Intestine
COMP=(AG_INTES) ; 5. AG in Intestine
COMP=(AA_INTES) ; 5. AA in Intestine
$PK
KA = THETA(1)*EXP(ETA(1)) ; absorption rate constant of AR
K20= THETA(2)*EXP(ETA(2)) ; elimination rate constant of AG from Central
K30= THETA(3)*EXP(ETA(3)) ; elimination rate constant of AA from central comp
V2 = THETA(4)*EXP(ETA(4)) ; volume of central
S2 = V2
S3 = V2
S4 = V2
Ki= THETA(5)*EXP(ETA(5)) ; Metabolism rate constant in intestine
Kb= THETA(6)*EXP(ETA(6)) ; Metabolism rate constant in Blood
Kl= THETA(7)*EXP(ETA(7)) ; Metabolism rate constant in Liver
F1 = THETA(8)*EXP(ETA(8)) ; Bioavailability
K10= THETA(9)*EXP(ETA(9)) ; elimination rate constant of AR from Central
K52= THETA(10)*EXP(ETA(10))
$DES
DADT(1)=-KA*A(1)
DADT(2) = K52*A(5)-Kb*A(2)-Kl*A(2)-K10*A(2)
DADT(3) = Ki*A(6)+Kl*A(2)-K20*A(3)
DADT(4) = Kb*A(7)+Kb*A(2)-K30*A(4)
DADT(5) = KA*A(1)-Ki*A(5)-Kb*A(5)-K52*A(5)
DADT(6) = Ki*A(5)-Ki*A(6)
DADT(7) = Kb*A(5)-Kb*A(7)
$ERROR
Y = F+ERR(1)
$THETA (0,0.03) ; KA(1/min)
(0,0.1) ; K20(1/min)
(0,0.1) ; K30(1/min)
(0,0.3) ; V2(L)
(0,0.15) ; Ki(1/min)
(0,0.15) ; Kb(1/min)
(0,0.05) ; Kl(1/min)
(0,0.01,1) ; F1
0 FIX ; K10
0 FIX ; K52
$OMEGA 0 FIX ; IIV KA
0 FIX ; IIV K20
0 FIX ; IIV K30
0 FIX ; IIV V2
0 FIX ; IIV Ki
0 FIX ; IIV Kb
0 FIX ; IIV Kl
0 FIX ; IIV BIO
0 FIX ; IIV K10
0 FIX ; IIV K52
$SIGMA 0.01 ; Residual error
$ESTIMATION METHOD=0 MAXEVAL=999 NOABORT SIG=5 PRINT=1
; Xpose
$COVARIANCE
$TABLE ID TIME DV MDV CMT DL RTE ONEHEADER NOPRINT
FILE=sdtab155.tab
$TABLE ID Ka K20 K30 V2 ONEHEADER NOPRINT FILE=patab155.tab
NM-TRAN MESSAGES
WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1
(WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION.
CREATING MUMODEL ROUTINE...
License Registered to: Zhang Zhen
Expiration Date: 14 JUN 2014
Current Date: 22 FEB 2014
Days until program expires : 112
1NONLINEAR MIXED EFFECTS MODEL PROGRAM (NONMEM) VERSION 7.2.0
ORIGINALLY DEVELOPED BY STUART BEAL, LEWIS SHEINER, AND ALISON BOECKMANN
CURRENT DEVELOPERS ARE ROBERT BAUER, ICON DEVELOPMENT SOLUTIONS,
AND ALISON BOECKMANN. IMPLEMENTATION, EFFICIENCY, AND STANDARDIZATION
PERFORMED BY NOUS INFOSYSTEMS.
PROBLEM NO.: 1
METABOLISM OF ARCTIGENIN IN RATS AFTER IV AND IG - ADVAN6
0DATA CHECKOUT RUN: NO
DATA SET LOCATED ON UNIT NO.: 2
THIS UNIT TO BE REWOUND: NO
NO. OF DATA RECS IN DATA SET: 830
NO. OF DATA ITEMS IN DATA SET: 9
ID DATA ITEM IS DATA ITEM NO.: 1
DEP VARIABLE IS DATA ITEM NO.: 3
MDV DATA ITEM IS DATA ITEM NO.: 5
0INDICES PASSED TO SUBROUTINE PRED:
7 2 4 0 0 0 6 0 0 0 0
0LABELS FOR DATA ITEMS:
ID TIME DV DOSE MDV CMT EVID DL RTE
0(NONBLANK) LABELS FOR PRED-DEFINED ITEMS:
KA K20 K30 V2
0FORMAT FOR DATA:
(E3.0,E4.0,2E12.0,3E2.0,E12.0,E2.0)
TOT. NO. OF OBS RECS: 735
TOT. NO. OF INDIVIDUALS: 34
0LENGTH OF THETA: 10
0DEFAULT THETA BOUNDARY TEST OMITTED: NO
0OMEGA HAS SIMPLE DIAGONAL FORM WITH DIMENSION: 10
0DEFAULT OMEGA BOUNDARY TEST OMITTED: NO
0SIGMA HAS SIMPLE DIAGONAL FORM WITH DIMENSION: 1
0DEFAULT SIGMA BOUNDARY TEST OMITTED: NO
0INITIAL ESTIMATE OF THETA:
LOWER BOUND INITIAL EST UPPER BOUND
0.0000E+00 0.3000E-01 0.1000E+07
0.0000E+00 0.1000E+00 0.1000E+07
0.0000E+00 0.1000E+00 0.1000E+07
0.0000E+00 0.3000E+00 0.1000E+07
0.0000E+00 0.1500E+00 0.1000E+07
0.0000E+00 0.1500E+00 0.1000E+07
0.0000E+00 0.5000E-01 0.1000E+07
0.0000E+00 0.1000E-01 0.1000E+01
0.0000E+00 0.0000E+00 0.0000E+00
0.0000E+00 0.0000E+00 0.0000E+00
0INITIAL ESTIMATE OF OMEGA:
0.0000E+00
0.0000E+00 0.0000E+00
0.0000E+00 0.0000E+00 0.0000E+00
0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00
0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00
0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00
0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00
0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00
0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00
0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00
0OMEGA CONSTRAINED TO BE THIS INITIAL ESTIMATE
0INITIAL ESTIMATE OF SIGMA:
0.1000E-01
0ESTIMATION STEP OMITTED: NO
EPS-ETA INTERACTION: NO
NO. OF FUNCT. EVALS. ALLOWED: 999
NO. OF SIG. FIGURES REQUIRED: 5
INTERMEDIATE PRINTOUT: YES
ESTIMATE OUTPUT TO MSF: NO
ABORT WITH PRED EXIT CODE 1: NO
IND. OBJ. FUNC. VALUES SORTED: NO
0COVARIANCE STEP OMITTED: NO
EIGENVLS. PRINTED: NO
SPECIAL COMPUTATION: NO
COMPRESSED FORMAT: NO
0TABLES STEP OMITTED: NO
NO. OF TABLES: 2
0-- TABLE 1 --
PRINTED: NO
HEADER: YES
FILE TO BE FORWARDED: NO
0USER-CHOSEN ITEMS:
ID TIME DV MDV CMT DL RTE
0-- TABLE 2 --
PRINTED: NO
HEADER: YES
FILE TO BE FORWARDED: NO
0USER-CHOSEN ITEMS:
ID KA K20 K30 V2
THE FOLLOWING LABELS ARE EQUIVALENT
PRED=NPRED
RES=NRES
WRES=NWRES
1DOUBLE PRECISION PREDPP VERSION 7.2.0
GENERAL NONLINEAR KINETICS MODEL (ADVAN6)
0MODEL SUBROUTINE USER-SUPPLIED - ID NO. 9999
0MAXIMUM NO. OF BASIC PK PARAMETERS: 8
0COMPARTMENT ATTRIBUTES
COMPT. NO. FUNCTION INITIAL ON/OFF DOSE DEFAULT DEFAULT
STATUS ALLOWED ALLOWED FOR DOSE FOR OBS.
1 LUMEN ON YES YES YES YES
2 AR_CENTR ON YES YES NO NO
3 AG_CENTR ON YES YES NO NO
4 AA_CENTR ON YES YES NO NO
5 AR_INTES ON YES YES NO NO
6 AG_INTES ON YES YES NO NO
7 AA_INTES ON YES YES NO NO
8 OUTPUT OFF YES NO NO NO
0NRD VALUE FROM SUBROUTINE TOL: 9
1
ADDITIONAL PK PARAMETERS - ASSIGNMENT OF ROWS IN GG
COMPT. NO. INDICES
SCALE BIOAVAIL. ZERO-ORDER ZERO-ORDER ABSORB
FRACTION RATE DURATION LAG
1 * 12 * * *
2 9 * * * *
3 10 * * * *
4 11 * * * *
5 * * * * *
6 * * * * *
7 * * * * *
8 * - - - -
- PARAMETER IS NOT ALLOWED FOR THIS MODEL
* PARAMETER IS NOT SUPPLIED BY PK SUBROUTINE;
WILL DEFAULT TO ONE IF APPLICABLE
0DATA ITEM INDICES USED BY PRED ARE:
EVENT ID DATA ITEM IS DATA ITEM NO.: 7
TIME DATA ITEM IS DATA ITEM NO.: 2
DOSE AMOUNT DATA ITEM IS DATA ITEM NO.: 4
COMPT. NO. DATA ITEM IS DATA ITEM NO.: 6
0PK SUBROUTINE CALLED WITH EVERY EVENT RECORD.
PK SUBROUTINE NOT CALLED AT NONEVENT (ADDITIONAL OR LAGGED) DOSE TIMES.
0DURING SIMULATION, ERROR SUBROUTINE CALLED WITH EVERY EVENT RECORD.
OTHERWISE, ERROR SUBROUTINE CALLED ONCE IN THIS PROBLEM.
0DES SUBROUTINE USES COMPACT STORAGE MODE.
1
#TBLN: 1
#METH: First Order
MONITORING OF SEARCH:
0ITERATION NO.: 0 OBJECTIVE VALUE: 472.635655732211 NO. OF FUNC. EVALS.: 10
CUMULATIVE NO. OF FUNC. EVALS.: 10
NPARAMETR: 3.0000E-02 1.0000E-01 1.0000E-01 3.0000E-01 1.5000E-01 1.5000E-01 5.0000E-02 1.0000E-02 1.0000E-02
PARAMETER: 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01
GRADIENT: -2.5969E+00 -5.2555E+02 -1.6635E+03 3.4847E+03 3.4351E-01 6.0708E+03 1.7942E+03 -6.8513E+00 -6.2449E+03
0ITERATION NO.: 1 OBJECTIVE VALUE: -1584.03589815483 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 21
NPARAMETR: 3.0004E-02 1.0256E-01 1.0832E-01 2.5376E-01 1.5000E-01 1.1206E-01 4.5871E-02 1.0003E-02 1.8221E-02
PARAMETER: 1.0012E-01 1.2525E-01 1.7991E-01 -6.7405E-02 9.9983E-02 -1.9164E-01 1.3810E-02 1.0033E-01 4.0000E-01
GRADIENT: -1.3522E+00 -5.9744E+02 -1.1172E+03 -3.3125E+03 2.6948E-01 8.2792E+02 5.5116E+02 -3.7555E+00 -1.2495E+03
0ITERATION NO.: 2 OBJECTIVE VALUE: -1901.02861858418 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 32
NPARAMETR: 3.0006E-02 1.0629E-01 1.1632E-01 2.9691E-01 1.5000E-01 1.0303E-01 4.4009E-02 1.0006E-02 2.2612E-02
PARAMETER: 1.0021E-01 1.6101E-01 2.5117E-01 8.9636E-02 9.9967E-02 -2.7562E-01 -2.7619E-02 1.0058E-01 5.0796E-01
GRADIENT: -9.5259E-01 -3.1505E+02 -8.3057E+00 1.2544E+03 1.3347E-01 6.5953E+02 7.8169E+02 -2.6552E+00 -2.9815E+02
0ITERATION NO.: 3 OBJECTIVE VALUE: -2103.09368908763 NO. OF FUNC. EVALS.: 12
CUMULATIVE NO. OF FUNC. EVALS.: 44
NPARAMETR: 3.0020E-02 1.2874E-01 1.2039E-01 3.0165E-01 1.4998E-01 9.9437E-02 3.1594E-02 1.0019E-02 1.8547E-02
PARAMETER: 1.0068E-01 3.5264E-01 2.8560E-01 1.0549E-01 9.9891E-02 -3.1111E-01 -3.5905E-01 1.0188E-01 4.0885E-01
GRADIENT: -1.0800E+00 -1.1989E+02 -8.1270E+01 1.1909E+03 2.1643E-01 5.2993E+02 3.2502E+02 -3.0044E+00 -1.8538E+02
0ITERATION NO.: 4 OBJECTIVE VALUE: -2116.64961857609 NO. OF FUNC. EVALS.: 13
CUMULATIVE NO. OF FUNC. EVALS.: 57
NPARAMETR: 3.0031E-02 1.3238E-01 1.2927E-01 2.9872E-01 1.4997E-01 9.6933E-02 3.1505E-02 1.0029E-02 1.6845E-02
PARAMETER: 1.0104E-01 3.8053E-01 3.5670E-01 9.5713E-02 9.9802E-02 -3.3662E-01 -3.6186E-01 1.0291E-01 3.6074E-01
GRADIENT: -1.1420E+00 -1.3417E+02 1.1305E+02 1.1481E+03 2.1347E-01 2.4746E+02 3.4477E+02 -3.2116E+00 -2.9972E+02
0ITERATION NO.: 5 OBJECTIVE VALUE: -2123.57587919221 NO. OF FUNC. EVALS.: 12
CUMULATIVE NO. OF FUNC. EVALS.: 69
NPARAMETR: 3.0048E-02 1.3725E-01 1.3548E-01 2.9446E-01 1.4995E-01 9.9854E-02 3.1611E-02 1.0044E-02 1.7112E-02
PARAMETER: 1.0159E-01 4.1664E-01 4.0363E-01 8.1356E-02 9.9674E-02 -3.0693E-01 -3.5852E-01 1.0447E-01 3.6861E-01
GRADIENT: -1.1149E+00 -1.2042E+02 1.5471E+02 1.0859E+03 2.0970E-01 3.2337E+02 3.4701E+02 -3.1374E+00 -2.6273E+02
0ITERATION NO.: 6 OBJECTIVE VALUE: -2137.81123398591 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 80
NPARAMETR: 3.0552E-02 2.5641E-01 1.2143E-01 2.8669E-01 1.4937E-01 9.2684E-02 4.2743E-02 1.0523E-02 1.6513E-02
PARAMETER: 1.1822E-01 1.0416E+00 2.9421E-01 5.4624E-02 9.5779E-02 -3.8144E-01 -5.6822E-02 1.5149E-01 3.5078E-01
GRADIENT: -1.0739E+00 -6.1414E+01 1.1062E+02 8.9269E+02 5.6810E-01 2.8251E+02 3.3444E+02 -2.9009E+00 -2.8668E+02
0ITERATION NO.: 7 OBJECTIVE VALUE: -2171.54292776754 NO. OF FUNC. EVALS.: 12
CUMULATIVE NO. OF FUNC. EVALS.: 92
NPARAMETR: 5.9252E-02 2.2720E-01 1.2628E-01 2.8553E-01 1.0854E-01 9.5076E-02 3.5333E-02 6.1472E-02 1.6414E-02
PARAMETER: 7.8061E-01 9.2066E-01 3.3334E-01 5.0551E-02 -2.2356E-01 -3.5596E-01 -2.4720E-01 1.9694E+00 3.4777E-01
GRADIENT: 5.4953E+00 -4.3400E+01 -1.3772E+01 1.6216E+02 -1.1860E+00 1.1376E+02 1.2219E+02 1.4202E+01 -2.2807E+02
0ITERATION NO.: 8 OBJECTIVE VALUE: -2177.36232224642 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 103
NPARAMETR: 3.3910E-02 2.1324E-01 1.2940E-01 2.8475E-01 1.1117E-01 9.6708E-02 3.1551E-02 1.6163E-02 1.6568E-02
PARAMETER: 2.2251E-01 8.5724E-01 3.5777E-01 4.7819E-02 -1.9956E-01 -3.3894E-01 -3.6043E-01 5.8639E-01 3.5246E-01
GRADIENT: -1.5004E+00 -2.3928E+01 -5.8585E+01 -1.8212E+02 4.6339E-01 1.6507E+01 3.1846E+01 -4.2083E+00 -2.0265E+02
0ITERATION NO.: 9 OBJECTIVE VALUE: -2185.39452737881 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 114
NPARAMETR: 3.2599E-02 1.9564E-01 1.3352E-01 2.8687E-01 1.0293E-01 9.9357E-02 2.8967E-02 2.0128E-02 1.7810E-02
PARAMETER: 1.8307E-01 7.7113E-01 3.8908E-01 5.5245E-02 -2.7654E-01 -3.1192E-01 -4.4588E-01 8.0982E-01 3.8858E-01
GRADIENT: -1.5945E+00 -1.6300E+01 -3.5164E+01 4.1010E+01 2.9069E-01 1.0505E+02 4.7402E+01 -4.3152E+00 -8.0378E+01
0ITERATION NO.: 10 OBJECTIVE VALUE: -2191.08006179836 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 125
NPARAMETR: 3.4562E-02 1.8823E-01 1.3836E-01 2.8819E-01 1.0747E-01 1.0053E-01 2.6295E-02 3.4266E-02 1.8626E-02
PARAMETER: 2.4157E-01 7.3248E-01 4.2472E-01 5.9847E-02 -2.3342E-01 -3.0022E-01 -5.4265E-01 1.3564E+00 4.1097E-01
GRADIENT: -1.0284E+00 -3.7666E+00 6.2247E+00 7.6688E+01 4.2596E-01 5.7200E+01 2.5712E+01 -3.5274E+00 -3.1698E+00
0ITERATION NO.: 11 OBJECTIVE VALUE: -2191.12833240367 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 136
NPARAMETR: 2.5509E-02 1.8791E-01 1.3992E-01 2.8914E-01 8.1640E-02 1.0041E-01 2.4768E-02 7.3175E-02 1.9020E-02
PARAMETER: -6.2178E-02 7.3079E-01 4.3587E-01 6.3130E-02 -5.0832E-01 -3.0136E-01 -6.0246E-01 2.1562E+00 4.2146E-01
GRADIENT: 3.5766E+00 2.7661E+00 6.1838E+00 2.1595E+01 -3.0045E+00 -5.1240E+00 3.6543E-01 7.2700E+00 2.7752E+01
0ITERATION NO.: 12 OBJECTIVE VALUE: -2192.25730367005 NO. OF FUNC. EVALS.: 12
CUMULATIVE NO. OF FUNC. EVALS.: 148
NPARAMETR: 2.3191E-02 1.8730E-01 1.3971E-01 2.8906E-01 1.0927E-01 1.0039E-01 2.4874E-02 6.8466E-02 1.8928E-02
PARAMETER: -1.5745E-01 7.2752E-01 4.3442E-01 6.2853E-02 -2.1685E-01 -3.0161E-01 -5.9819E-01 2.0846E+00 4.1902E-01
GRADIENT: 1.8357E+00 1.0281E+00 9.2616E+00 2.2875E+01 -1.8400E-01 -5.7831E+00 1.6091E+00 3.0130E+00 2.2836E+01
0ITERATION NO.: 13 OBJECTIVE VALUE: -2192.47380017315 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 159
NPARAMETR: 1.9511E-02 1.8757E-01 1.3942E-01 2.8892E-01 9.4554E-02 1.0033E-01 2.5021E-02 6.4395E-02 1.8829E-02
PARAMETER: -3.3020E-01 7.2896E-01 4.3235E-01 6.2351E-02 -3.6146E-01 -3.0216E-01 -5.9231E-01 2.0190E+00 4.1641E-01
GRADIENT: 8.2002E-02 2.1293E+00 6.7115E+00 1.6893E+01 -1.1161E+00 -3.9812E+00 1.9924E+00 2.6562E-01 1.5591E+01
0ITERATION NO.: 14 OBJECTIVE VALUE: -2192.63578292016 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 170
NPARAMETR: 1.6143E-02 1.8524E-01 1.3939E-01 2.8888E-01 1.2567E-01 1.0044E-01 2.4851E-02 7.0101E-02 1.8647E-02
PARAMETER: -5.1968E-01 7.1648E-01 4.3208E-01 6.2233E-02 -7.6945E-02 -3.0105E-01 -5.9912E-01 2.1100E+00 4.1155E-01
GRADIENT: -1.0121E-01 4.6864E-01 1.9734E+00 -4.4690E-01 4.7033E-01 -6.0907E+00 4.1585E-02 -2.2726E-01 1.6367E+00
0ITERATION NO.: 15 OBJECTIVE VALUE: -2192.66214505526 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 181
NPARAMETR: 1.7084E-02 1.8403E-01 1.3960E-01 2.8892E-01 1.1677E-01 1.0058E-01 2.4759E-02 6.8128E-02 1.8660E-02
PARAMETER: -4.6306E-01 7.0995E-01 4.3360E-01 6.2367E-02 -1.5046E-01 -2.9969E-01 -6.0282E-01 2.0793E+00 4.1189E-01
GRADIENT: -6.9219E-02 4.9396E-01 2.5391E+00 6.8094E+00 1.1085E-01 -1.1690E+00 1.2824E+00 -1.5263E-01 2.6952E+00
0ITERATION NO.: 16 OBJECTIVE VALUE: -2192.67463486966 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 192
NPARAMETR: 1.7780E-02 1.8067E-01 1.4001E-01 2.8900E-01 1.0992E-01 1.0087E-01 2.4448E-02 6.7042E-02 1.8630E-02
PARAMETER: -4.2315E-01 6.9148E-01 4.3657E-01 6.2646E-02 -2.1087E-01 -2.9682E-01 -6.1548E-01 2.0621E+00 4.1110E-01
GRADIENT: 4.0619E-02 1.5521E-01 8.0177E-01 7.0777E+00 -1.4458E-01 3.4719E+00 1.3433E+00 6.7061E-02 3.8205E-01
0ITERATION NO.: 17 OBJECTIVE VALUE: -2192.67869860498 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 203
NPARAMETR: 1.6911E-02 1.7989E-01 1.4007E-01 2.8902E-01 1.1373E-01 1.0089E-01 2.4347E-02 6.8528E-02 1.8616E-02
PARAMETER: -4.7320E-01 6.8718E-01 4.3701E-01 6.2702E-02 -1.7679E-01 -2.9660E-01 -6.1963E-01 2.0856E+00 4.1071E-01
GRADIENT: -1.6002E-02 4.3973E-02 -1.2812E-01 -2.8757E-01 4.0075E-02 -1.3803E-01 -3.4046E-02 -7.0671E-03 -7.5073E-01
0ITERATION NO.: 18 OBJECTIVE VALUE: -2192.67914769140 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 214
NPARAMETR: 1.7135E-02 1.7964E-01 1.4011E-01 2.8902E-01 1.1261E-01 1.0091E-01 2.4325E-02 6.8120E-02 1.8620E-02
PARAMETER: -4.6006E-01 6.8581E-01 4.3728E-01 6.2728E-02 -1.8673E-01 -2.9638E-01 -6.2050E-01 2.0792E+00 4.1082E-01
GRADIENT: 4.6022E-03 2.7826E-02 -8.3384E-02 3.8925E-01 -2.7436E-03 3.7165E-01 7.8134E-02 2.2714E-02 -4.1263E-01
0ITERATION NO.: 19 OBJECTIVE VALUE: -2192.67925687901 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 225
NPARAMETR: 1.7307E-02 1.7935E-01 1.4015E-01 2.8903E-01 1.1208E-01 1.0093E-01 2.4298E-02 6.7701E-02 1.8626E-02
PARAMETER: -4.5010E-01 6.8417E-01 4.3757E-01 6.2758E-02 -1.9142E-01 -2.9621E-01 -6.2162E-01 2.0726E+00 4.1098E-01
GRADIENT: 8.1746E-03 -2.7929E-03 -1.7738E-02 1.0865E-01 -1.4009E-02 1.4144E-01 2.3893E-02 1.9726E-02 5.1374E-02
0ITERATION NO.: 20 OBJECTIVE VALUE: -2192.67928262994 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 236
NPARAMETR: 1.7304E-02 1.7940E-01 1.4014E-01 2.8903E-01 1.1243E-01 1.0092E-01 2.4303E-02 6.7628E-02 1.8625E-02
PARAMETER: -4.5024E-01 6.8443E-01 4.3750E-01 6.2753E-02 -1.8832E-01 -2.9628E-01 -6.2141E-01 2.0714E+00 4.1096E-01
GRADIENT: -1.4662E-03 -7.8786E-03 -2.5135E-03 -1.1398E-01 4.3611E-03 -7.8414E-02 -3.7411E-03 -1.8825E-03 -6.1883E-03
0ITERATION NO.: 21 OBJECTIVE VALUE: -2192.67928593377 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 247
NPARAMETR: 1.7322E-02 1.7937E-01 1.4015E-01 2.8903E-01 1.1232E-01 1.0093E-01 2.4301E-02 6.7598E-02 1.8625E-02
PARAMETER: -4.4924E-01 6.8430E-01 4.3753E-01 6.2756E-02 -1.8926E-01 -2.9626E-01 -6.2151E-01 2.0709E+00 4.1097E-01
GRADIENT: 9.0800E-05 -6.2187E-03 3.9153E-04 -3.6232E-02 8.0735E-05 -2.0765E-02 3.7919E-03 6.8627E-04 9.5696E-03
0ITERATION NO.: 22 OBJECTIVE VALUE: -2192.67928616965 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 258
NPARAMETR: 1.7331E-02 1.7937E-01 1.4015E-01 2.8903E-01 1.1230E-01 1.0093E-01 2.4300E-02 6.7576E-02 1.8625E-02
PARAMETER: -4.4870E-01 6.8429E-01 4.3753E-01 6.2758E-02 -1.8942E-01 -2.9625E-01 -6.2154E-01 2.0706E+00 4.1096E-01
GRADIENT: 1.2344E-04 -1.5181E-03 -5.9970E-05 5.4870E-03 -3.8123E-04 4.6436E-03 2.8774E-03 1.2666E-04 -4.6552E-04
0ITERATION NO.: 23 OBJECTIVE VALUE: -2192.67928619987 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 269
NPARAMETR: 1.7329E-02 1.7937E-01 1.4015E-01 2.8903E-01 1.1231E-01 1.0093E-01 2.4300E-02 6.7580E-02 1.8625E-02
PARAMETER: -4.4882E-01 6.8431E-01 4.3753E-01 6.2757E-02 -1.8934E-01 -2.9625E-01 -6.2153E-01 2.0707E+00 4.1096E-01
GRADIENT: 1.8643E-05 -6.9697E-04 1.0030E-04 8.9995E-04 -7.6854E-05 6.3012E-04 1.1117E-03 1.2957E-05 -5.4043E-04
0ITERATION NO.: 24 OBJECTIVE VALUE: -2192.67928620817 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 280
NPARAMETR: 1.7328E-02 1.7938E-01 1.4015E-01 2.8903E-01 1.1232E-01 1.0093E-01 2.4300E-02 6.7583E-02 1.8625E-02
PARAMETER: -4.4888E-01 6.8432E-01 4.3753E-01 6.2757E-02 -1.8930E-01 -2.9625E-01 -6.2153E-01 2.0707E+00 4.1096E-01
GRADIENT: -2.5124E-05 5.8545E-04 -1.0975E-04 -9.3951E-04 8.8403E-05 -7.8823E-04 -9.6286E-04 -2.7847E-05 2.0393E-04
0ITERATION NO.: 25 OBJECTIVE VALUE: -2192.67928620883 NO. OF FUNC. EVALS.: 11
CUMULATIVE NO. OF FUNC. EVALS.: 291
NPARAMETR: 1.7328E-02 1.7938E-01 1.4015E-01 2.8903E-01 1.1232E-01 1.0093E-01 2.4300E-02 6.7582E-02 1.8625E-02
PARAMETER: -4.4887E-01 6.8431E-01 4.3753E-01 6.2757E-02 -1.8931E-01 -2.9625E-01 -6.2153E-01 2.0707E+00 4.1096E-01
GRADIENT: -1.2968E-05 2.9080E-04 -5.2903E-05 -4.6566E-04 4.4679E-05 -4.0202E-04 -4.7850E-04 -1.4626E-05 8.8855E-05
0ITERATION NO.: 26 OBJECTIVE VALUE: -2192.67928620883 NO. OF FUNC. EVALS.: 21
CUMULATIVE NO. OF FUNC. EVALS.: 312
NPARAMETR: 1.7328E-02 1.7938E-01 1.4015E-01 2.8903E-01 1.1232E-01 1.0093E-01 2.4300E-02 6.7582E-02 1.8625E-02
PARAMETER: -4.4887E-01 6.8431E-01 4.3753E-01 6.2757E-02 -1.8931E-01 -2.9625E-01 -6.2153E-01 2.0707E+00 4.1096E-01
GRADIENT: -2.6644E-05 -1.8510E-04 -6.2642E-03 -1.5368E-02 3.9154E-05 -1.1733E-02 -2.4035E-03 -1.7580E-04 -5.9523E-03
0ITERATION NO.: 27 OBJECTIVE VALUE: -2192.67928625219 NO. OF FUNC. EVALS.: 22
CUMULATIVE NO. OF FUNC. EVALS.: 334
NPARAMETR: 1.7327E-02 1.7937E-01 1.4015E-01 2.8903E-01 1.1232E-01 1.0093E-01 2.4300E-02 6.7585E-02 1.8625E-02
PARAMETER: -4.4893E-01 6.8430E-01 4.3754E-01 6.2757E-02 -1.8932E-01 -2.9625E-01 -6.2155E-01 2.0707E+00 4.1097E-01
GRADIENT: -2.1728E-05 -1.4514E-04 1.4499E-05 -6.4801E-05 3.8793E-05 -2.9717E-03 -8.0078E-05 -6.2083E-05 -2.0222E-03
0ITERATION NO.: 28 OBJECTIVE VALUE: -2192.67928625469 NO. OF FUNC. EVALS.: 20
CUMULATIVE NO. OF FUNC. EVALS.: 354
NPARAMETR: 1.7327E-02 1.7937E-01 1.4015E-01 2.8903E-01 1.1232E-01 1.0093E-01 2.4300E-02 6.7585E-02 1.8625E-02
PARAMETER: -4.4894E-01 6.8429E-01 4.3754E-01 6.2757E-02 -1.8932E-01 -2.9624E-01 -6.2155E-01 2.0707E+00 4.1097E-01
GRADIENT: 0.0000E+00 -1.8740E-05 5.1551E-05 3.3901E-04 4.4436E-06 -1.6502E-05 3.6545E-05 1.2078E-07 -5.4829E-05
0ITERATION NO.: 29 OBJECTIVE VALUE: -2192.67928625469 NO. OF FUNC. EVALS.: 0
CUMULATIVE NO. OF FUNC. EVALS.: 354
NPARAMETR: 1.7327E-02 1.7937E-01 1.4015E-01 2.8903E-01 1.1232E-01 1.0093E-01 2.4300E-02 6.7585E-02 1.8625E-02
PARAMETER: -4.4894E-01 6.8429E-01 4.3754E-01 6.2757E-02 -1.8932E-01 -2.9624E-01 -6.2155E-01 2.0707E+00 4.1097E-01
GRADIENT: 0.0000E+00 -1.8740E-05 5.1551E-05 3.3901E-04 4.4436E-06 -1.6502E-05 3.6545E-05 1.2078E-07 -5.4829E-05
#TERM:
0MINIMIZATION SUCCESSFUL
NO. OF FUNCTION EVALUATIONS USED: 354
NO. OF SIG. DIGITS IN FINAL EST.: 5.4
#TERE:
Elapsed estimation time in seconds: 4.15
Elapsed covariance time in seconds: 2.34
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER ********************
#OBJT:************** MINIMUM VALUE OF OBJECTIVE FUNCTION ********************
******************** ********************
************************************************************************************************************************
#OBJV:******************************************** -2192.679 **************************************************
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER ********************
******************** FINAL PARAMETER ESTIMATE ********************
******************** ********************
************************************************************************************************************************
THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10
1.73E-02 1.79E-01 1.40E-01 2.89E-01 1.12E-01 1.01E-01 2.43E-02 6.76E-02 0.00E+00 0.00E+00
OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ********
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA7 ETA8 ETA9 ET10
ETA1
+ 0.00E+00
ETA2
+ 0.00E+00 0.00E+00
ETA3
+ 0.00E+00 0.00E+00 0.00E+00
ETA4
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA5
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA6
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA7
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA8
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA9
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ET10
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS ****
EPS1
EPS1
+ 1.86E-02
1
OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS *******
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA7 ETA8 ETA9 ET10
ETA1
+ 0.00E+00
ETA2
+ 0.00E+00 0.00E+00
ETA3
+ 0.00E+00 0.00E+00 0.00E+00
ETA4
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA5
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA6
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA7
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA8
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ETA9
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
ET10
+ 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00 0.00E+00
SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS ***
EPS1
EPS1
+ 1.36E-01
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER ********************
******************** STANDARD ERROR OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
THETA - VECTOR OF FIXED EFFECTS PARAMETERS *********
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10
1.25E-02 3.68E-02 5.53E-03 1.42E-02 3.01E-02 4.29E-03 4.59E-03 2.79E-02 ......... .........
OMEGA - COV MATRIX FOR RANDOM EFFECTS - ETAS ********
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA7 ETA8 ETA9 ET10
ETA1
+ .........
ETA2
+ ......... .........
ETA3
+ ......... ......... .........
ETA4
+ ......... ......... ......... .........
ETA5
+ ......... ......... ......... ......... .........
ETA6
+ ......... ......... ......... ......... ......... .........
ETA7
+ ......... ......... ......... ......... ......... ......... .........
ETA8
+ ......... ......... ......... ......... ......... ......... ......... .........
ETA9
+ ......... ......... ......... ......... ......... ......... ......... ......... .........
ET10
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
SIGMA - COV MATRIX FOR RANDOM EFFECTS - EPSILONS ****
EPS1
EPS1
+ 5.59E-03
1
OMEGA - CORR MATRIX FOR RANDOM EFFECTS - ETAS *******
ETA1 ETA2 ETA3 ETA4 ETA5 ETA6 ETA7 ETA8 ETA9 ET10
ETA1
+ .........
ETA2
+ ......... .........
ETA3
+ ......... ......... .........
ETA4
+ ......... ......... ......... .........
ETA5
+ ......... ......... ......... ......... .........
ETA6
+ ......... ......... ......... ......... ......... .........
ETA7
+ ......... ......... ......... ......... ......... ......... .........
ETA8
+ ......... ......... ......... ......... ......... ......... ......... .........
ETA9
+ ......... ......... ......... ......... ......... ......... ......... ......... .........
ET10
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
SIGMA - CORR MATRIX FOR RANDOM EFFECTS - EPSILONS ***
EPS1
EPS1
+ 2.05E-02
1
************************************************************************************************************************
******************** ********************
******************** FIRST ORDER ********************
******************** COVARIANCE MATRIX OF ESTIMATE ********************
******************** ********************
************************************************************************************************************************
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10 OM0101 OM0102
OM0103 OM0104 OM0105 OM0106 OM0107 OM0108 OM0109 OM0110 OM0202 OM0203 OM0204 OM0205
OM0206 OM0207 OM0208 OM0209 OM0210 OM0303 OM0304 OM0305 OM0306 OM0307 OM0308 OM0309
OM0310 OM0404 OM0405 OM0406 OM0407 OM0408 OM0409 OM0410 OM0505 OM0506 OM0507 OM0508
OM0509 OM0510 OM0606 OM0607 OM0608 OM0609 OM0610 OM0707 OM0708 OM0709 OM0710 OM0808
OM0809 OM0810 OM0909 OM0910 OM1010 SG0101
TH 1
+ 1.55E-04
TH 2
+ -1.04E-04 1.35E-03
TH 3
+ 7.42E-06 -7.39E-05 3.06E-05
TH 4
+ -2.11E-06 5.27E-05 -5.50E-05 2.00E-04
TH 5
+ -2.79E-04 7.43E-04 -5.38E-05 2.86E-05 9.08E-04
TH 6
+ 2.36E-06 -4.24E-05 1.08E-05 -4.19E-05 -1.41E-05 1.84E-05
TH 7
+ -1.23E-05 1.60E-04 -1.53E-05 2.17E-05 9.15E-05 -5.95E-06 2.11E-05
TH 8
+ -3.36E-04 4.40E-04 -3.34E-05 4.80E-05 6.90E-04 -1.99E-05 5.41E-05 7.80E-04
TH 9
+ ......... ......... ......... ......... ......... ......... ......... ......... .........
TH10
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM0101
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM0102
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM0103
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
.........
OM0104
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... .........
OM0105
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... .........
OM0106
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... .........
OM0107
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... .........
OM0108
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... .........
1
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10 OM0101 OM0102
OM0103 OM0104 OM0105 OM0106 OM0107 OM0108 OM0109 OM0110 OM0202 OM0203 OM0204 OM0205
OM0206 OM0207 OM0208 OM0209 OM0210 OM0303 OM0304 OM0305 OM0306 OM0307 OM0308 OM0309
OM0310 OM0404 OM0405 OM0406 OM0407 OM0408 OM0409 OM0410 OM0505 OM0506 OM0507 OM0508
OM0509 OM0510 OM0606 OM0607 OM0608 OM0609 OM0610 OM0707 OM0708 OM0709 OM0710 OM0808
OM0809 OM0810 OM0909 OM0910 OM1010 SG0101
OM0109
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... .........
OM0110
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... .........
OM0202
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... .........
OM0203
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM0204
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM0205
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM0206
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
.........
OM0207
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... .........
OM0208
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... .........
OM0209
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... .........
OM0210
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... .........
OM0303
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... .........
OM0304
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... .........
1
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10 OM0101 OM0102
OM0103 OM0104 OM0105 OM0106 OM0107 OM0108 OM0109 OM0110 OM0202 OM0203 OM0204 OM0205
OM0206 OM0207 OM0208 OM0209 OM0210 OM0303 OM0304 OM0305 OM0306 OM0307 OM0308 OM0309
OM0310 OM0404 OM0405 OM0406 OM0407 OM0408 OM0409 OM0410 OM0505 OM0506 OM0507 OM0508
OM0509 OM0510 OM0606 OM0607 OM0608 OM0609 OM0610 OM0707 OM0708 OM0709 OM0710 OM0808
OM0809 OM0810 OM0909 OM0910 OM1010 SG0101
OM0305
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... .........
OM0306
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... .........
OM0307
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM0308
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM0309
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM0310
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
.........
OM0404
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... .........
OM0405
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... .........
OM0406
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... .........
OM0407
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... .........
1
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10 OM0101 OM0102
OM0103 OM0104 OM0105 OM0106 OM0107 OM0108 OM0109 OM0110 OM0202 OM0203 OM0204 OM0205
OM0206 OM0207 OM0208 OM0209 OM0210 OM0303 OM0304 OM0305 OM0306 OM0307 OM0308 OM0309
OM0310 OM0404 OM0405 OM0406 OM0407 OM0408 OM0409 OM0410 OM0505 OM0506 OM0507 OM0508
OM0509 OM0510 OM0606 OM0607 OM0608 OM0609 OM0610 OM0707 OM0708 OM0709 OM0710 OM0808
OM0809 OM0810 OM0909 OM0910 OM1010 SG0101
OM0408
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... .........
OM0409
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... .........
OM0410
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... .........
OM0505
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... .........
OM0506
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM0507
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM0508
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
OM0509
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
.........
OM0510
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... .........
1
TH 1 TH 2 TH 3 TH 4 TH 5 TH 6 TH 7 TH 8 TH 9 TH10 OM0101 OM0102
OM0103 OM0104 OM0105 OM0106 OM0107 OM0108 OM0109 OM0110 OM0202 OM0203 OM0204 OM0205
OM0206 OM0207 OM0208 OM0209 OM0210 OM0303 OM0304 OM0305 OM0306 OM0307 OM0308 OM0309
OM0310 OM0404 OM0405 OM0406 OM0407 OM0408 OM0409 OM0410 OM0505 OM0506 OM0507 OM0508
OM0509 OM0510 OM0606 OM0607 OM0608 OM0609 OM0610 OM0707 OM0708 OM0709 OM0710 OM0808
OM0809 OM0810 OM0909 OM0910 OM1010 SG0101
OM0606
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... .........
OM0607
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... .........
OM0608
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... .........
OM0609
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... .........
OM0610
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... .........
OM0707
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... .........
OM0708
+ ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........
......... ......... ......... ......... ......... ......... ......... ......... ......... ......... ......... .........