proposed1658 | BQ.1.8, XBF(?) or CJ.1(?)

[ktmeaton]

• pango-designation issue: #1658
• covSPECTRUM query: TBD

Parents

Clade: BA.5.3,CJ.1
Lineage: BQ.1.8*,BA.2*
Lineage Confidence: 0.993,0.977

Immunity

RBD Level: 6
RBD Substitutions: S:K444T,S:L452R,S:N460K,S:F486P,S:F490S,S:R493Q
Immune Escape: 0.7621
ACE2 Binding: 0.8882

Immune Escape Ranking

Higher values indicate an increased capacity to evade antibodies.

TBD

ACE2 Binding Ranking

Higher values indicate an increased capacity for viral entry into the host cell.

TBD

Alleles

proposed1658 is successfully detected with the sc2rf mode for voc-2022 and voc-2023:

The second parent could be CJ.1 (BA.2.75.3*):

Or the second parent could be XBF :

And is less likely to be XBB:

Breakpoints

Breakpoint 1: 22918:23018

Tasks

• resources/breakpoints.tsv Updated

[ktmeaton]

The genetic similarities between XBB, XBF, and CJ.1 are going to cause problems for identifying diagnostic mutations when I next update the sc2rf mutation frequencies. This will also impact #234.