Support for mixed-bag (or known as lumped) models to calculate biomass fluxes of each taxon?

[hellopeccat]

Dear MICOM team, dear community,

Pretty glad to learn MICOM. I have got some community-scale models generated by a mixed-bag function annotation directly from contigs in advance, but I am going to binning those contigs into MAGs to get the abundance of each taxon, together with mapping MAGs to public model databases to deliever a specific biomass reaction to each taxon. In this case, could I use MICOM to calculate biomass fluxes of each taxon directly from the set of biomass reactions integrated to my original mixed-bag models? (which means that except for setting various biomass production, we would consider the community as a single supra organism.)

I am also considering to firstly annotate functions of each taxon, subsequently build individual models for each taxon, and finally merge them into a compartmentalized model. However it seems to be much time-cost for the separate annotation than mixed-bag annotation, since there would be 300+ species in each sample. Directly use the matched public models may be an alternative solution, but for some reasons I prefer to use my custom counterparts. The long run time is the most essential reason that I would like to learn whether the strategy of ctFBA is available for mixed-bag models in silico computation.

Thanks for any comment.