diff --git a/404.html b/404.html
index 4c03641..b00cfaf 100644
--- a/404.html
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@@ -8,68 +8,55 @@
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     <a class="navbar-brand me-2" href="https://mtmorgan.github.io/AlphaMissenseR/index.html">AlphaMissenseR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.5</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
 
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+<li class="nav-item"><a class="nav-link" href="https://mtmorgan.github.io/AlphaMissenseR/reference/index.html">Reference</a></li>
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+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles">
+<li><a class="dropdown-item" href="https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="https://mtmorgan.github.io/AlphaMissenseR/articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="https://mtmorgan.github.io/AlphaMissenseR/articles/issues.html">D. Issues &amp; Solutions</a></li>
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+<li class="nav-item"><a class="nav-link" href="https://mtmorgan.github.io/AlphaMissenseR/news/index.html">Changelog</a></li>
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+<ul class="navbar-nav">
+<li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="search.json">
+</form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
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-      <img src="https://mtmorgan.github.io/AlphaMissenseR/" class="logo" alt=""><h1>Page not found (404)</h1>
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+      <h1>Page not found (404)</h1>
+
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@@ -83,15 +70,15 @@
 </div>
 
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-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
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diff --git a/articles/alphafold.html b/articles/alphafold.html
index 60396b4..c338aeb 100644
--- a/articles/alphafold.html
+++ b/articles/alphafold.html
@@ -5,67 +5,51 @@
 <meta charset="utf-8">
 <meta http-equiv="X-UA-Compatible" content="IE=edge">
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-<!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="B. AlphaFold Integration">
-<meta property="og:description" content="AlphaMissenseR">
-<!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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-<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]-->
+<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet">
+<link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet">
+<script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="B. AlphaFold Integration">
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-    
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light" data-bs-theme="light"><div class="container">
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+    <nav class="navbar navbar-expand-lg fixed-top bg-light" data-bs-theme="light" aria-label="Site navigation"><div class="container">
+
     <a class="navbar-brand me-2" href="../index.html">AlphaMissenseR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.5</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
 
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-    <a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a>
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+<li class="nav-item"><a class="nav-link" href="../reference/index.html">Reference</a></li>
+<li class="nav-item dropdown">
+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles">
+<li><a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a></li>
+  </ul>
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+<li class="nav-item"><a class="nav-link" href="../news/index.html">Changelog</a></li>
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-<form class="form-inline my-2 my-lg-0" role="search">
-        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off">
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-     
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+<ul class="navbar-nav">
+<li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json">
+</form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
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 </nav><div class="container template-article">
 
@@ -74,7 +58,8 @@
 <link href="alphafold_files/htmltools-fill-0.5.8.1/fill.css" rel="stylesheet">
 <script src="alphafold_files/htmlwidgets-1.6.4/htmlwidgets.js"></script><script src="alphafold_files/r3dmol-1.6.2/3Dmol-nojquery-min.js"></script><script src="alphafold_files/r3dmol-binding-0.1.2/r3dmol.js"></script><div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>B. AlphaFold Integration</h1>
+
+      <h1>B. AlphaFold Integration</h1>
             
       
       <small class="dont-index">Source: <a href="https://github.com/mtmorgan/AlphaMissenseR/blob/HEAD/vignettes/alphafold.Rmd" class="external-link"><code>vignettes/alphafold.Rmd</code></a></small>
@@ -120,7 +105,7 @@ <h2 id="introduction">Introduction<a class="anchor" aria-label="anchor" href="#i
 <div class="sourceCode" id="cb4"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="../reference/AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"aa_substitutions"</span><span class="op">)</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Source:   table&lt;aa_substitutions&gt; [?? x 4]</span></span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span></span>
 <span><span class="co">#&gt;    uniprot_id protein_variant am_pathogenicity am_class  </span></span>
 <span><span class="co">#&gt;    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>      <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>                      <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>     </span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;"> 1</span> A0A024R1R8 M1A                        0.467 ambiguous </span></span>
@@ -133,11 +118,10 @@ <h2 id="introduction">Introduction<a class="anchor" aria-label="anchor" href="#i
 <span><span class="co">#&gt; <span style="color: #BCBCBC;"> 8</span> A0A024R1R8 M1I                        0.321 benign    </span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;"> 9</span> A0A024R1R8 M1K                        0.288 benign    </span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;">10</span> A0A024R1R8 M1L                        0.175 benign    </span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># ℹ more rows</span></span></span></code></pre></div>
-<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r">
-<code class="sourceCode R"><span><span class="fu"><a href="../reference/AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"hg38"</span><span class="op">)</span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># ℹ more rows</span></span></span>
+<span><span class="fu"><a href="../reference/AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"hg38"</span><span class="op">)</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Source:   table&lt;hg38&gt; [?? x 10]</span></span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span></span>
 <span><span class="co">#&gt;    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant</span></span>
 <span><span class="co">#&gt;    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>  <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>      <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>             <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>          </span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;"> 1</span> chr1  <span style="text-decoration: underline;">69</span>094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L            </span></span>
@@ -165,12 +149,12 @@ <h3 id="fast-path">Fast path<a class="anchor" aria-label="anchor" href="#fast-pa
 <p>Figure 3F of the <a href="https://www.science.org/doi/10.1126/science.adg7492" class="external-link">AlphaMissense</a>
 publication visualizes mean pathogenicity for UniProt id P35557. Filter
 amino acid data for that identifier</p>
-<div class="sourceCode" id="cb6"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb5"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">P35557_aa</span> <span class="op">&lt;-</span></span>
 <span>    <span class="fu"><a href="../reference/AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"aa_substitutions"</span><span class="op">)</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">uniprot_id</span> <span class="op">==</span> <span class="st">"P35557"</span><span class="op">)</span></span></code></pre></div>
 <p>and visualization median pathogenicity with</p>
-<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb6"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="../reference/AlphaFold.html">af_prediction_view</a></span><span class="op">(</span><span class="va">P35557_aa</span><span class="op">)</span></span></code></pre></div>
 <div class="r3dmol html-widget html-fill-item" id="htmlwidget-ac96cb3ee4656e2e9ec3" style="width:100%;height:500px;"></div>
 <script type="application/json" data-for="htmlwidget-ac96cb3ee4656e2e9ec3">{"x":{"id":"ac96cb3ee4656e2e9ec3","configs":{"nomouse":false,"backgroundColor":"white","cartoonQuality":5,"lowerZoomLimit":5,"upperZoomLimit":400,"antialias":true,"orthographic":false,"disableFog":false},"api":[{"method":"addModel","data":["ATOM      1  N   MET A   1      37.762  17.693 -31.307  1.00 60.70           N  \nATOM      2  CA  MET A   1      37.985  16.974 -30.030  1.00 60.70           C  \nATOM      3  C   MET A   1      37.126  17.503 -28.884  1.00 60.70           C  \nATOM      4  CB  MET A   1      39.461  16.796 -29.632  1.00 60.70           C  \nATOM      5  O   MET A   1      36.269  16.755 -28.443  1.00 60.70           O  \nATOM      6  CG  MET A   1      40.135  15.744 -30.527  1.00 60.70           C  \nATOM      7  SD  MET A   1      41.521  14.854 -29.765  1.00 60.70           S  \nATOM      8  CE  MET A   1      42.862  16.064 -29.883  1.00 60.70           C  \nATOM      9  N   LEU A   2      37.301  18.742 -28.389  1.00 66.32           N  \nATOM     10  CA  LEU A   2      36.431  19.268 -27.311  1.00 66.32           C  \nATOM     11  C   LEU A   2      34.963  19.419 -27.754  1.00 66.32           C  \nATOM     12  CB  LEU A   2      36.978  20.607 -26.772  1.00 66.32           C  \nATOM     13  O   LEU A   2      34.069  19.025 -27.014  1.00 66.32           O  \nATOM     14  CG  LEU A   2      38.201  20.479 -25.844  1.00 66.32           C  \nATOM     15  CD1 LEU A   2      38.800  21.861 -25.582  1.00 66.32           C  \nATOM     16  CD2 LEU A   2      37.846  19.854 -24.492  1.00 66.32           C  \nATOM     17  N   ASP A   3      34.733  19.913 -28.976  1.00 78.24           N  \nATOM     18  CA  ASP A   3      33.388  20.032 -29.565  1.00 78.24           C  \nATOM     19  C   ASP A   3      32.722  18.652 -29.737  1.00 78.24           C  \nATOM     20  CB  ASP A   3      33.514  20.801 -30.895  1.00 78.24           C  \nATOM     21  O   ASP A   3      31.591  18.446 -29.312  1.00 78.24           O  \nATOM     22  CG  ASP A   3      32.176  21.209 -31.531  1.00 78.24           C  \nATOM     23  OD1 ASP A   3      31.128  21.192 -30.857  1.00 78.24           O  \nATOM     24  OD2 ASP A   3      32.176  21.545 -32.735  1.00 78.24           O  \nATOM     25  N   ASP A   4      33.462  17.654 -30.235  1.00 81.51           N  \nATOM     26  CA  ASP A   4      32.934  16.293 -30.417  1.00 81.51           C  \nATOM     27  C   ASP A   4      32.518  15.647 -29.089  1.00 81.51           C  \nATOM     28  CB  ASP A   4      33.964  15.398 -31.121  1.00 81.51           C  \nATOM     29  O   ASP A   4      31.462  15.023 -29.009  1.00 81.51           O  \nATOM     30  CG  ASP A   4      34.515  16.040 -32.390  1.00 81.51           C  \nATOM     31  OD1 ASP A   4      33.711  16.482 -33.231  1.00 81.51           O  \nATOM     32  OD2 ASP A   4      35.761  16.218 -32.427  1.00 81.51           O  \nATOM     33  N   ARG A   5      33.312  15.823 -28.023  1.00 79.75           N  \nATOM     34  CA  ARG A   5      32.974  15.294 -26.694  1.00 79.75           C  \nATOM     35  C   ARG A   5      31.726  15.960 -26.119  1.00 79.75           C  \nATOM     36  CB  ARG A   5      34.178  15.412 -25.751  1.00 79.75           C  \nATOM     37  O   ARG A   5      30.853  15.255 -25.625  1.00 79.75           O  \nATOM     38  CG  ARG A   5      33.856  14.778 -24.392  1.00 79.75           C  \nATOM     39  CD  ARG A   5      35.055  14.843 -23.452  1.00 79.75           C  \nATOM     40  NE  ARG A   5      34.650  14.406 -22.113  1.00 79.75           N  \nATOM     41  NH1 ARG A   5      36.721  14.355 -21.118  1.00 79.75           N  \nATOM     42  NH2 ARG A   5      34.868  13.787 -19.975  1.00 79.75           N  \nATOM     43  CZ  ARG A   5      35.425  14.182 -21.077  1.00 79.75           C  \nATOM     44  N   ALA A   6      31.626  17.286 -26.219  1.00 82.64           N  \nATOM     45  CA  ALA A   6      30.450  18.018 -25.756  1.00 82.64           C  \nATOM     46  C   ALA A   6      29.185  17.595 -26.522  1.00 82.64           C  \nATOM     47  CB  ALA A   6      30.727  19.518 -25.899  1.00 82.64           C  \nATOM     48  O   ALA A   6      28.138  17.389 -25.913  1.00 82.64           O  \nATOM     49  N   ARG A   7      29.291  17.387 -27.843  1.00 85.02           N  \nATOM     50  CA  ARG A   7      28.191  16.868 -28.670  1.00 85.02           C  \nATOM     51  C   ARG A   7      27.776  15.453 -28.266  1.00 85.02           C  \nATOM     52  CB  ARG A   7      28.583  16.907 -30.151  1.00 85.02           C  \nATOM     53  O   ARG A   7      26.583  15.187 -28.172  1.00 85.02           O  \nATOM     54  CG  ARG A   7      28.633  18.335 -30.709  1.00 85.02           C  \nATOM     55  CD  ARG A   7      29.134  18.280 -32.151  1.00 85.02           C  \nATOM     56  NE  ARG A   7      29.458  19.619 -32.661  1.00 85.02           N  \nATOM     57  NH1 ARG A   7      29.195  19.167 -34.898  1.00 85.02           N  \nATOM     58  NH2 ARG A   7      29.938  21.162 -34.242  1.00 85.02           N  \nATOM     59  CZ  ARG A   7      29.515  19.979 -33.927  1.00 85.02           C  \nATOM     60  N   MET A   8      28.731  14.563 -27.991  1.00 84.70           N  \nATOM     61  CA  MET A   8      28.434  13.203 -27.522  1.00 84.70           C  \nATOM     62  C   MET A   8      27.769  13.195 -26.138  1.00 84.70           C  \nATOM     63  CB  MET A   8      29.709  12.349 -27.495  1.00 84.70           C  \nATOM     64  O   MET A   8      26.806  12.462 -25.934  1.00 84.70           O  \nATOM     65  CG  MET A   8      30.181  11.952 -28.899  1.00 84.70           C  \nATOM     66  SD  MET A   8      31.588  10.802 -28.930  1.00 84.70           S  \nATOM     67  CE  MET A   8      32.896  11.823 -28.208  1.00 84.70           C  \nATOM     68  N   GLU A   9      28.237  14.020 -25.196  1.00 85.54           N  \nATOM     69  CA  GLU A   9      27.622  14.147 -23.865  1.00 85.54           C  \nATOM     70  C   GLU A   9      26.205  14.746 -23.944  1.00 85.54           C  \nATOM     71  CB  GLU A   9      28.535  14.970 -22.929  1.00 85.54           C  \nATOM     72  O   GLU A   9      25.303  14.277 -23.248  1.00 85.54           O  \nATOM     73  CG  GLU A   9      29.768  14.174 -22.443  1.00 85.54           C  \nATOM     74  CD  GLU A   9      30.755  14.978 -21.563  1.00 85.54           C  \nATOM     75  OE1 GLU A   9      31.864  14.443 -21.269  1.00 85.54           O  \nATOM     76  OE2 GLU A   9      30.443  16.135 -21.210  1.00 85.54           O  \nATOM     77  N   ALA A  10      25.976  15.720 -24.833  1.00 88.64           N  \nATOM     78  CA  ALA A  10      24.648  16.280 -25.085  1.00 88.64           C  \nATOM     79  C   ALA A  10      23.686  15.241 -25.686  1.00 88.64           C  \nATOM     80  CB  ALA A  10      24.789  17.515 -25.982  1.00 88.64           C  \nATOM     81  O   ALA A  10      22.583  15.072 -25.170  1.00 88.64           O  \nATOM     82  N   ALA A  11      24.125  14.491 -26.703  1.00 91.48           N  \nATOM     83  CA  ALA A  11      23.331  13.423 -27.315  1.00 91.48           C  \nATOM     84  C   ALA A  11      23.015  12.292 -26.319  1.00 91.48           C  \nATOM     85  CB  ALA A  11      24.099  12.894 -28.532  1.00 91.48           C  \nATOM     86  O   ALA A  11      21.897  11.779 -26.285  1.00 91.48           O  \nATOM     87  N   LYS A  12      23.980  11.934 -25.456  1.00 91.93           N  \nATOM     88  CA  LYS A  12      23.772  10.989 -24.350  1.00 91.93           C  \nATOM     89  C   LYS A  12      22.669  11.483 -23.412  1.00 91.93           C  \nATOM     90  CB  LYS A  12      25.108  10.761 -23.614  1.00 91.93           C  \nATOM     91  O   LYS A  12      21.759  10.724 -23.093  1.00 91.93           O  \nATOM     92  CG  LYS A  12      24.963   9.814 -22.416  1.00 91.93           C  \nATOM     93  CD  LYS A  12      26.284   9.567 -21.671  1.00 91.93           C  \nATOM     94  CE  LYS A  12      25.910   8.628 -20.526  1.00 91.93           C  \nATOM     95  NZ  LYS A  12      27.026   8.112 -19.694  1.00 91.93           N  \nATOM     96  N   LYS A  13      22.736  12.747 -22.984  1.00 92.69           N  \nATOM     97  CA  LYS A  13      21.739  13.346 -22.086  1.00 92.69           C  \nATOM     98  C   LYS A  13      20.345  13.381 -22.715  1.00 92.69           C  \nATOM     99  CB  LYS A  13      22.216  14.743 -21.667  1.00 92.69           C  \nATOM    100  O   LYS A  13      19.381  13.041 -22.043  1.00 92.69           O  \nATOM    101  CG  LYS A  13      21.267  15.361 -20.633  1.00 92.69           C  \nATOM    102  CD  LYS A  13      21.762  16.734 -20.177  1.00 92.69           C  \nATOM    103  CE  LYS A  13      20.733  17.298 -19.195  1.00 92.69           C  \nATOM    104  NZ  LYS A  13      21.122  18.638 -18.700  1.00 92.69           N  \nATOM    105  N   GLU A  14      20.245  13.753 -23.988  1.00 94.75           N  \nATOM    106  CA  GLU A  14      18.976  13.773 -24.724  1.00 94.75           C  \nATOM    107  C   GLU A  14      18.333  12.382 -24.778  1.00 94.75           C  \nATOM    108  CB  GLU A  14      19.245  14.333 -26.127  1.00 94.75           C  \nATOM    109  O   GLU A  14      17.157  12.237 -24.454  1.00 94.75           O  \nATOM    110  CG  GLU A  14      17.969  14.520 -26.962  1.00 94.75           C  \nATOM    111  CD  GLU A  14      18.247  15.162 -28.333  1.00 94.75           C  \nATOM    112  OE1 GLU A  14      17.259  15.447 -29.045  1.00 94.75           O  \nATOM    113  OE2 GLU A  14      19.436  15.386 -28.664  1.00 94.75           O  \nATOM    114  N   LYS A  15      19.119  11.342 -25.083  1.00 96.79           N  \nATOM    115  CA  LYS A  15      18.615   9.965 -25.139  1.00 96.79           C  \nATOM    116  C   LYS A  15      18.205   9.422 -23.764  1.00 96.79           C  \nATOM    117  CB  LYS A  15      19.659   9.083 -25.833  1.00 96.79           C  \nATOM    118  O   LYS A  15      17.219   8.698 -23.669  1.00 96.79           O  \nATOM    119  CG  LYS A  15      19.039   7.759 -26.297  1.00 96.79           C  \nATOM    120  CD  LYS A  15      20.049   6.938 -27.107  1.00 96.79           C  \nATOM    121  CE  LYS A  15      19.474   5.553 -27.397  1.00 96.79           C  \nATOM    122  NZ  LYS A  15      20.485   4.644 -27.983  1.00 96.79           N  \nATOM    123  N   VAL A  16      18.922   9.792 -22.698  1.00 97.86           N  \nATOM    124  CA  VAL A  16      18.512   9.475 -21.318  1.00 97.86           C  \nATOM    125  C   VAL A  16      17.164  10.119 -21.001  1.00 97.86           C  \nATOM    126  CB  VAL A  16      19.572   9.912 -20.288  1.00 97.86           C  \nATOM    127  O   VAL A  16      16.260   9.426 -20.548  1.00 97.86           O  \nATOM    128  CG1 VAL A  16      19.068   9.804 -18.842  1.00 97.86           C  \nATOM    129  CG2 VAL A  16      20.837   9.051 -20.388  1.00 97.86           C  \nATOM    130  N   GLU A  17      16.999  11.419 -21.260  1.00 97.61           N  \nATOM    131  CA  GLU A  17      15.728  12.103 -20.983  1.00 97.61           C  \nATOM    132  C   GLU A  17      14.587  11.564 -21.858  1.00 97.61           C  \nATOM    133  CB  GLU A  17      15.868  13.625 -21.141  1.00 97.61           C  \nATOM    134  O   GLU A  17      13.459  11.505 -21.386  1.00 97.61           O  \nATOM    135  CG  GLU A  17      16.793  14.298 -20.104  1.00 97.61           C  \nATOM    136  CD  GLU A  17      16.328  14.240 -18.629  1.00 97.61           C  \nATOM    137  OE1 GLU A  17      17.206  14.199 -17.734  1.00 97.61           O  \nATOM    138  OE2 GLU A  17      15.119  14.354 -18.324  1.00 97.61           O  \nATOM    139  N   GLN A  18      14.861  11.099 -23.082  1.00 97.55           N  \nATOM    140  CA  GLN A  18      13.860  10.435 -23.920  1.00 97.55           C  \nATOM    141  C   GLN A  18      13.335   9.136 -23.288  1.00 97.55           C  \nATOM    142  CB  GLN A  18      14.450  10.176 -25.315  1.00 97.55           C  \nATOM    143  O   GLN A  18      12.127   8.924 -23.278  1.00 97.55           O  \nATOM    144  CG  GLN A  18      13.397   9.607 -26.278  1.00 97.55           C  \nATOM    145  CD  GLN A  18      13.946   9.282 -27.662  1.00 97.55           C  \nATOM    146  NE2 GLN A  18      13.108   8.791 -28.548  1.00 97.55           N  \nATOM    147  OE1 GLN A  18      15.115   9.435 -27.983  1.00 97.55           O  \nATOM    148  N   ILE A  19      14.217   8.287 -22.745  1.00 98.10           N  \nATOM    149  CA  ILE A  19      13.818   7.049 -22.050  1.00 98.10           C  \nATOM    150  C   ILE A  19      13.058   7.390 -20.762  1.00 98.10           C  \nATOM    151  CB  ILE A  19      15.062   6.167 -21.773  1.00 98.10           C  \nATOM    152  O   ILE A  19      11.996   6.847 -20.481  1.00 98.10           O  \nATOM    153  CG1 ILE A  19      15.640   5.633 -23.105  1.00 98.10           C  \nATOM    154  CG2 ILE A  19      14.723   4.992 -20.835  1.00 98.10           C  \nATOM    155  CD1 ILE A  19      17.038   5.015 -22.978  1.00 98.10           C  \nATOM    156  N   LEU A  20      13.567   8.337 -19.974  1.00 98.38           N  \nATOM    157  CA  LEU A  20      12.933   8.711 -18.708  1.00 98.38           C  \nATOM    158  C   LEU A  20      11.607   9.469 -18.895  1.00 98.38           C  \nATOM    159  CB  LEU A  20      13.935   9.504 -17.858  1.00 98.38           C  \nATOM    160  O   LEU A  20      10.766   9.454 -17.995  1.00 98.38           O  \nATOM    161  CG  LEU A  20      15.193   8.714 -17.441  1.00 98.38           C  \nATOM    162  CD1 LEU A  20      16.049   9.599 -16.539  1.00 98.38           C  \nATOM    163  CD2 LEU A  20      14.874   7.425 -16.684  1.00 98.38           C  \nATOM    164  N   ALA A  21      11.383  10.096 -20.054  1.00 97.79           N  \nATOM    165  CA  ALA A  21      10.121  10.750 -20.391  1.00 97.79           C  \nATOM    166  C   ALA A  21       8.939   9.770 -20.467  1.00 97.79           C  \nATOM    167  CB  ALA A  21      10.278  11.535 -21.698  1.00 97.79           C  \nATOM    168  O   ALA A  21       7.809  10.195 -20.246  1.00 97.79           O  \nATOM    169  N   GLU A  22       9.175   8.470 -20.686  1.00 97.70           N  \nATOM    170  CA  GLU A  22       8.130   7.432 -20.664  1.00 97.70           C  \nATOM    171  C   GLU A  22       7.412   7.350 -19.305  1.00 97.70           C  \nATOM    172  CB  GLU A  22       8.753   6.063 -20.988  1.00 97.70           C  \nATOM    173  O   GLU A  22       6.244   6.979 -19.228  1.00 97.70           O  \nATOM    174  CG  GLU A  22       9.398   6.003 -22.382  1.00 97.70           C  \nATOM    175  CD  GLU A  22      10.020   4.629 -22.687  1.00 97.70           C  \nATOM    176  OE1 GLU A  22       9.765   4.133 -23.809  1.00 97.70           O  \nATOM    177  OE2 GLU A  22      10.766   4.094 -21.830  1.00 97.70           O  \nATOM    178  N   PHE A  23       8.089   7.739 -18.220  1.00 98.41           N  \nATOM    179  CA  PHE A  23       7.521   7.754 -16.871  1.00 98.41           C  \nATOM    180  C   PHE A  23       6.689   9.009 -16.572  1.00 98.41           C  \nATOM    181  CB  PHE A  23       8.659   7.600 -15.852  1.00 98.41           C  \nATOM    182  O   PHE A  23       6.019   9.075 -15.537  1.00 98.41           O  \nATOM    183  CG  PHE A  23       9.287   6.222 -15.844  1.00 98.41           C  \nATOM    184  CD1 PHE A  23       8.852   5.269 -14.906  1.00 98.41           C  \nATOM    185  CD2 PHE A  23      10.265   5.873 -16.795  1.00 98.41           C  \nATOM    186  CE1 PHE A  23       9.353   3.958 -14.946  1.00 98.41           C  \nATOM    187  CE2 PHE A  23      10.782   4.568 -16.821  1.00 98.41           C  \nATOM    188  CZ  PHE A  23      10.315   3.610 -15.905  1.00 98.41           C  \nATOM    189  N   GLN A  24       6.742  10.029 -17.433  1.00 97.81           N  \nATOM    190  CA  GLN A  24       6.075  11.305 -17.196  1.00 97.81           C  \nATOM    191  C   GLN A  24       4.607  11.238 -17.615  1.00 97.81           C  \nATOM    192  CB  GLN A  24       6.800  12.450 -17.915  1.00 97.81           C  \nATOM    193  O   GLN A  24       4.276  11.236 -18.796  1.00 97.81           O  \nATOM    194  CG  GLN A  24       8.225  12.661 -17.389  1.00 97.81           C  \nATOM    195  CD  GLN A  24       8.949  13.804 -18.094  1.00 97.81           C  \nATOM    196  NE2 GLN A  24      10.250  13.903 -17.927  1.00 97.81           N  \nATOM    197  OE1 GLN A  24       8.385  14.634 -18.787  1.00 97.81           O  \nATOM    198  N   LEU A  25       3.719  11.260 -16.624  1.00 97.99           N  \nATOM    199  CA  LEU A  25       2.274  11.340 -16.833  1.00 97.99           C  \nATOM    200  C   LEU A  25       1.817  12.801 -16.866  1.00 97.99           C  \nATOM    201  CB  LEU A  25       1.557  10.545 -15.730  1.00 97.99           C  \nATOM    202  O   LEU A  25       2.172  13.582 -15.976  1.00 97.99           O  \nATOM    203  CG  LEU A  25       1.915   9.047 -15.707  1.00 97.99           C  \nATOM    204  CD1 LEU A  25       1.310   8.402 -14.463  1.00 97.99           C  \nATOM    205  CD2 LEU A  25       1.400   8.308 -16.942  1.00 97.99           C  \nATOM    206  N   GLN A  26       1.007  13.160 -17.861  1.00 97.23           N  \nATOM    207  CA  GLN A  26       0.364  14.472 -17.935  1.00 97.23           C  \nATOM    208  C   GLN A  26      -0.884  14.515 -17.047  1.00 97.23           C  \nATOM    209  CB  GLN A  26       0.018  14.820 -19.393  1.00 97.23           C  \nATOM    210  O   GLN A  26      -1.458  13.488 -16.691  1.00 97.23           O  \nATOM    211  CG  GLN A  26       1.233  14.789 -20.334  1.00 97.23           C  \nATOM    212  CD  GLN A  26       2.348  15.730 -19.889  1.00 97.23           C  \nATOM    213  NE2 GLN A  26       3.576  15.264 -19.824  1.00 97.23           N  \nATOM    214  OE1 GLN A  26       2.130  16.894 -19.582  1.00 97.23           O  \nATOM    215  N   GLU A  27      -1.367  15.714 -16.716  1.00 97.87           N  \nATOM    216  CA  GLU A  27      -2.582  15.857 -15.900  1.00 97.87           C  \nATOM    217  C   GLU A  27      -3.803  15.163 -16.533  1.00 97.87           C  \nATOM    218  CB  GLU A  27      -2.862  17.348 -15.667  1.00 97.87           C  \nATOM    219  O   GLU A  27      -4.608  14.557 -15.828  1.00 97.87           O  \nATOM    220  CG  GLU A  27      -3.965  17.557 -14.622  1.00 97.87           C  \nATOM    221  CD  GLU A  27      -4.282  19.041 -14.430  1.00 97.87           C  \nATOM    222  OE1 GLU A  27      -5.455  19.410 -14.694  1.00 97.87           O  \nATOM    223  OE2 GLU A  27      -3.356  19.780 -14.028  1.00 97.87           O  \nATOM    224  N   GLU A  28      -3.923  15.188 -17.863  1.00 98.21           N  \nATOM    225  CA  GLU A  28      -4.998  14.483 -18.570  1.00 98.21           C  \nATOM    226  C   GLU A  28      -4.882  12.956 -18.468  1.00 98.21           C  \nATOM    227  CB  GLU A  28      -5.060  14.935 -20.039  1.00 98.21           C  \nATOM    228  O   GLU A  28      -5.907  12.277 -18.381  1.00 98.21           O  \nATOM    229  CG  GLU A  28      -5.570  16.379 -20.201  1.00 98.21           C  \nATOM    230  CD  GLU A  28      -6.943  16.611 -19.536  1.00 98.21           C  \nATOM    231  OE1 GLU A  28      -7.112  17.646 -18.842  1.00 98.21           O  \nATOM    232  OE2 GLU A  28      -7.826  15.725 -19.637  1.00 98.21           O  \nATOM    233  N   ASP A  29      -3.665  12.410 -18.392  1.00 98.50           N  \nATOM    234  CA  ASP A  29      -3.448  10.982 -18.139  1.00 98.50           C  \nATOM    235  C   ASP A  29      -3.942  10.614 -16.738  1.00 98.50           C  \nATOM    236  CB  ASP A  29      -1.964  10.623 -18.308  1.00 98.50           C  \nATOM    237  O   ASP A  29      -4.709   9.666 -16.567  1.00 98.50           O  \nATOM    238  CG  ASP A  29      -1.460  10.921 -19.721  1.00 98.50           C  \nATOM    239  OD1 ASP A  29      -2.213  10.628 -20.684  1.00 98.50           O  \nATOM    240  OD2 ASP A  29      -0.351  11.498 -19.804  1.00 98.50           O  \nATOM    241  N   LEU A  30      -3.613  11.438 -15.741  1.00 98.74           N  \nATOM    242  CA  LEU A  30      -4.077  11.241 -14.367  1.00 98.74           C  \nATOM    243  C   LEU A  30      -5.600  11.355 -14.247  1.00 98.74           C  \nATOM    244  CB  LEU A  30      -3.368  12.228 -13.427  1.00 98.74           C  \nATOM    245  O   LEU A  30      -6.217  10.562 -13.538  1.00 98.74           O  \nATOM    246  CG  LEU A  30      -1.833  12.144 -13.448  1.00 98.74           C  \nATOM    247  CD1 LEU A  30      -1.252  13.129 -12.434  1.00 98.74           C  \nATOM    248  CD2 LEU A  30      -1.317  10.739 -13.139  1.00 98.74           C  \nATOM    249  N   LYS A  31      -6.238  12.269 -14.988  1.00 98.66           N  \nATOM    250  CA  LYS A  31      -7.707  12.352 -15.057  1.00 98.66           C  \nATOM    251  C   LYS A  31      -8.329  11.112 -15.701  1.00 98.66           C  \nATOM    252  CB  LYS A  31      -8.140  13.608 -15.819  1.00 98.66           C  \nATOM    253  O   LYS A  31      -9.411  10.706 -15.280  1.00 98.66           O  \nATOM    254  CG  LYS A  31      -7.930  14.895 -15.012  1.00 98.66           C  \nATOM    255  CD  LYS A  31      -8.233  16.108 -15.898  1.00 98.66           C  \nATOM    256  CE  LYS A  31      -7.854  17.401 -15.178  1.00 98.66           C  \nATOM    257  NZ  LYS A  31      -7.629  18.508 -16.136  1.00 98.66           N  \nATOM    258  N   LYS A  32      -7.693  10.495 -16.705  1.00 98.62           N  \nATOM    259  CA  LYS A  32      -8.167   9.215 -17.268  1.00 98.62           C  \nATOM    260  C   LYS A  32      -8.091   8.099 -16.226  1.00 98.62           C  \nATOM    261  CB  LYS A  32      -7.346   8.796 -18.490  1.00 98.62           C  \nATOM    262  O   LYS A  32      -9.092   7.412 -16.031  1.00 98.62           O  \nATOM    263  CG  LYS A  32      -7.537   9.617 -19.775  1.00 98.62           C  \nATOM    264  CD  LYS A  32      -6.441   9.123 -20.728  1.00 98.62           C  \nATOM    265  CE  LYS A  32      -6.374   9.750 -22.114  1.00 98.62           C  \nATOM    266  NZ  LYS A  32      -5.176   9.188 -22.800  1.00 98.62           N  \nATOM    267  N   VAL A  33      -6.949   7.954 -15.549  1.00 98.75           N  \nATOM    268  CA  VAL A  33      -6.742   6.968 -14.470  1.00 98.75           C  \nATOM    269  C   VAL A  33      -7.793   7.156 -13.373  1.00 98.75           C  \nATOM    270  CB  VAL A  33      -5.309   7.083 -13.904  1.00 98.75           C  \nATOM    271  O   VAL A  33      -8.487   6.207 -13.024  1.00 98.75           O  \nATOM    272  CG1 VAL A  33      -5.048   6.190 -12.687  1.00 98.75           C  \nATOM    273  CG2 VAL A  33      -4.269   6.678 -14.956  1.00 98.75           C  \nATOM    274  N   MET A  34      -7.991   8.394 -12.913  1.00 98.59           N  \nATOM    275  CA  MET A  34      -8.990   8.764 -11.907  1.00 98.59           C  \nATOM    276  C   MET A  34     -10.418   8.364 -12.312  1.00 98.59           C  \nATOM    277  CB  MET A  34      -8.888  10.279 -11.692  1.00 98.59           C  \nATOM    278  O   MET A  34     -11.116   7.709 -11.542  1.00 98.59           O  \nATOM    279  CG  MET A  34      -9.846  10.811 -10.629  1.00 98.59           C  \nATOM    280  SD  MET A  34      -9.858  12.617 -10.534  1.00 98.59           S  \nATOM    281  CE  MET A  34     -10.885  13.004 -11.976  1.00 98.59           C  \nATOM    282  N   ARG A  35     -10.856   8.705 -13.533  1.00 98.46           N  \nATOM    283  CA  ARG A  35     -12.208   8.361 -14.017  1.00 98.46           C  \nATOM    284  C   ARG A  35     -12.406   6.852 -14.168  1.00 98.46           C  \nATOM    285  CB  ARG A  35     -12.486   9.042 -15.362  1.00 98.46           C  \nATOM    286  O   ARG A  35     -13.491   6.345 -13.897  1.00 98.46           O  \nATOM    287  CG  ARG A  35     -12.665  10.564 -15.263  1.00 98.46           C  \nATOM    288  CD  ARG A  35     -12.835  11.130 -16.681  1.00 98.46           C  \nATOM    289  NE  ARG A  35     -12.507  12.569 -16.761  1.00 98.46           N  \nATOM    290  NH1 ARG A  35     -11.067  12.494 -18.566  1.00 98.46           N  \nATOM    291  NH2 ARG A  35     -11.467  14.434 -17.582  1.00 98.46           N  \nATOM    292  CZ  ARG A  35     -11.692  13.152 -17.631  1.00 98.46           C  \nATOM    293  N   ARG A  36     -11.376   6.126 -14.617  1.00 98.48           N  \nATOM    294  CA  ARG A  36     -11.418   4.658 -14.715  1.00 98.48           C  \nATOM    295  C   ARG A  36     -11.486   4.009 -13.337  1.00 98.48           C  \nATOM    296  CB  ARG A  36     -10.213   4.133 -15.496  1.00 98.48           C  \nATOM    297  O   ARG A  36     -12.287   3.100 -13.166  1.00 98.48           O  \nATOM    298  CG  ARG A  36     -10.339   4.398 -16.994  1.00 98.48           C  \nATOM    299  CD  ARG A  36      -9.145   3.772 -17.711  1.00 98.48           C  \nATOM    300  NE  ARG A  36      -9.166   4.112 -19.139  1.00 98.48           N  \nATOM    301  NH1 ARG A  36      -6.947   3.707 -19.570  1.00 98.48           N  \nATOM    302  NH2 ARG A  36      -8.190   4.754 -21.070  1.00 98.48           N  \nATOM    303  CZ  ARG A  36      -8.107   4.169 -19.915  1.00 98.48           C  \nATOM    304  N   MET A  37     -10.737   4.529 -12.364  1.00 98.54           N  \nATOM    305  CA  MET A  37     -10.836   4.106 -10.967  1.00 98.54           C  \nATOM    306  C   MET A  37     -12.268   4.283 -10.446  1.00 98.54           C  \nATOM    307  CB  MET A  37      -9.819   4.884 -10.114  1.00 98.54           C  \nATOM    308  O   MET A  37     -12.851   3.321  -9.966  1.00 98.54           O  \nATOM    309  CG  MET A  37      -9.827   4.452  -8.643  1.00 98.54           C  \nATOM    310  SD  MET A  37      -9.274   2.755  -8.341  1.00 98.54           S  \nATOM    311  CE  MET A  37      -7.488   2.936  -8.582  1.00 98.54           C  \nATOM    312  N   GLN A  38     -12.880   5.464 -10.616  1.00 98.33           N  \nATOM    313  CA  GLN A  38     -14.271   5.705 -10.189  1.00 98.33           C  \nATOM    314  C   GLN A  38     -15.258   4.718 -10.827  1.00 98.33           C  \nATOM    315  CB  GLN A  38     -14.700   7.139 -10.536  1.00 98.33           C  \nATOM    316  O   GLN A  38     -16.119   4.178 -10.136  1.00 98.33           O  \nATOM    317  CG  GLN A  38     -14.044   8.196  -9.640  1.00 98.33           C  \nATOM    318  CD  GLN A  38     -14.454   9.607 -10.059  1.00 98.33           C  \nATOM    319  NE2 GLN A  38     -15.281  10.282  -9.287  1.00 98.33           N  \nATOM    320  OE1 GLN A  38     -14.039  10.098 -11.103  1.00 98.33           O  \nATOM    321  N   LYS A  39     -15.099   4.435 -12.126  1.00 98.26           N  \nATOM    322  CA  LYS A  39     -15.931   3.455 -12.832  1.00 98.26           C  \nATOM    323  C   LYS A  39     -15.781   2.044 -12.251  1.00 98.26           C  \nATOM    324  CB  LYS A  39     -15.588   3.488 -14.326  1.00 98.26           C  \nATOM    325  O   LYS A  39     -16.784   1.358 -12.082  1.00 98.26           O  \nATOM    326  CG  LYS A  39     -16.510   2.563 -15.129  1.00 98.26           C  \nATOM    327  CD  LYS A  39     -16.054   2.460 -16.584  1.00 98.26           C  \nATOM    328  CE  LYS A  39     -16.928   1.410 -17.273  1.00 98.26           C  \nATOM    329  NZ  LYS A  39     -16.346   0.981 -18.564  1.00 98.26           N  \nATOM    330  N   GLU A  40     -14.561   1.602 -11.957  1.00 98.47           N  \nATOM    331  CA  GLU A  40     -14.345   0.280 -11.356  1.00 98.47           C  \nATOM    332  C   GLU A  40     -14.818   0.221  -9.900  1.00 98.47           C  \nATOM    333  CB  GLU A  40     -12.879  -0.159 -11.496  1.00 98.47           C  \nATOM    334  O   GLU A  40     -15.348  -0.803  -9.485  1.00 98.47           O  \nATOM    335  CG  GLU A  40     -12.487  -0.500 -12.944  1.00 98.47           C  \nATOM    336  CD  GLU A  40     -13.431  -1.540 -13.573  1.00 98.47           C  \nATOM    337  OE1 GLU A  40     -14.058  -1.223 -14.620  1.00 98.47           O  \nATOM    338  OE2 GLU A  40     -13.704  -2.589 -12.945  1.00 98.47           O  \nATOM    339  N   MET A  41     -14.747   1.325  -9.150  1.00 98.52           N  \nATOM    340  CA  MET A  41     -15.372   1.426  -7.826  1.00 98.52           C  \nATOM    341  C   MET A  41     -16.901   1.289  -7.907  1.00 98.52           C  \nATOM    342  CB  MET A  41     -15.023   2.765  -7.165  1.00 98.52           C  \nATOM    343  O   MET A  41     -17.491   0.554  -7.120  1.00 98.52           O  \nATOM    344  CG  MET A  41     -13.541   2.937  -6.815  1.00 98.52           C  \nATOM    345  SD  MET A  41     -13.135   4.622  -6.272  1.00 98.52           S  \nATOM    346  CE  MET A  41     -13.899   4.565  -4.629  1.00 98.52           C  \nATOM    347  N   ASP A  42     -17.551   1.949  -8.874  1.00 97.88           N  \nATOM    348  CA  ASP A  42     -18.991   1.778  -9.120  1.00 97.88           C  \nATOM    349  C   ASP A  42     -19.338   0.327  -9.445  1.00 97.88           C  \nATOM    350  CB  ASP A  42     -19.461   2.650 -10.299  1.00 97.88           C  \nATOM    351  O   ASP A  42     -20.325  -0.204  -8.938  1.00 97.88           O  \nATOM    352  CG  ASP A  42     -19.789   4.081  -9.908  1.00 97.88           C  \nATOM    353  OD1 ASP A  42     -20.393   4.257  -8.825  1.00 97.88           O  \nATOM    354  OD2 ASP A  42     -19.489   4.993 -10.704  1.00 97.88           O  \nATOM    355  N   ARG A  43     -18.524  -0.329 -10.281  1.00 98.22           N  \nATOM    356  CA  ARG A  43     -18.731  -1.739 -10.617  1.00 98.22           C  \nATOM    357  C   ARG A  43     -18.532  -2.648  -9.408  1.00 98.22           C  \nATOM    358  CB  ARG A  43     -17.810  -2.179 -11.759  1.00 98.22           C  \nATOM    359  O   ARG A  43     -19.302  -3.589  -9.242  1.00 98.22           O  \nATOM    360  CG  ARG A  43     -18.212  -1.578 -13.109  1.00 98.22           C  \nATOM    361  CD  ARG A  43     -17.203  -2.002 -14.180  1.00 98.22           C  \nATOM    362  NE  ARG A  43     -17.327  -3.429 -14.549  1.00 98.22           N  \nATOM    363  NH1 ARG A  43     -15.137  -3.775 -15.187  1.00 98.22           N  \nATOM    364  NH2 ARG A  43     -16.578  -5.461 -15.274  1.00 98.22           N  \nATOM    365  CZ  ARG A  43     -16.350  -4.207 -14.993  1.00 98.22           C  \nATOM    366  N   GLY A  44     -17.534  -2.360  -8.576  1.00 97.95           N  \nATOM    367  CA  GLY A  44     -17.220  -3.124  -7.373  1.00 97.95           C  \nATOM    368  C   GLY A  44     -18.308  -3.056  -6.309  1.00 97.95           C  \nATOM    369  O   GLY A  44     -18.507  -4.024  -5.587  1.00 97.95           O  \nATOM    370  N   LEU A  45     -19.032  -1.943  -6.218  1.00 97.67           N  \nATOM    371  CA  LEU A  45     -20.094  -1.757  -5.226  1.00 97.67           C  \nATOM    372  C   LEU A  45     -21.442  -2.378  -5.617  1.00 97.67           C  \nATOM    373  CB  LEU A  45     -20.238  -0.252  -4.981  1.00 97.67           C  \nATOM    374  O   LEU A  45     -22.279  -2.606  -4.743  1.00 97.67           O  \nATOM    375  CG  LEU A  45     -19.154   0.318  -4.056  1.00 97.67           C  \nATOM    376  CD1 LEU A  45     -19.211   1.836  -4.100  1.00 97.67           C  \nATOM    377  CD2 LEU A  45     -19.334  -0.116  -2.603  1.00 97.67           C  \nATOM    378  N   ARG A  46     -21.659  -2.647  -6.909  1.00 97.47           N  \nATOM    379  CA  ARG A  46     -22.913  -3.205  -7.432  1.00 97.47           C  \nATOM    380  C   ARG A  46     -22.898  -4.721  -7.450  1.00 97.47           C  \nATOM    381  CB  ARG A  46     -23.181  -2.692  -8.842  1.00 97.47           C  \nATOM    382  O   ARG A  46     -21.939  -5.324  -7.931  1.00 97.47           O  \nATOM    383  CG  ARG A  46     -23.542  -1.211  -8.853  1.00 97.47           C  \nATOM    384  CD  ARG A  46     -23.707  -0.786 -10.308  1.00 97.47           C  \nATOM    385  NE  ARG A  46     -23.852   0.671 -10.405  1.00 97.47           N  \nATOM    386  NH1 ARG A  46     -24.542   0.732 -12.582  1.00 97.47           N  \nATOM    387  NH2 ARG A  46     -24.261   2.643 -11.441  1.00 97.47           N  \nATOM    388  CZ  ARG A  46     -24.219   1.341 -11.473  1.00 97.47           C  \nATOM    389  N   LEU A  47     -24.004  -5.335  -7.041  1.00 95.11           N  \nATOM    390  CA  LEU A  47     -24.113  -6.792  -6.948  1.00 95.11           C  \nATOM    391  C   LEU A  47     -23.919  -7.473  -8.314  1.00 95.11           C  \nATOM    392  CB  LEU A  47     -25.477  -7.133  -6.323  1.00 95.11           C  \nATOM    393  O   LEU A  47     -23.271  -8.511  -8.398  1.00 95.11           O  \nATOM    394  CG  LEU A  47     -25.678  -8.632  -6.030  1.00 95.11           C  \nATOM    395  CD1 LEU A  47     -24.730  -9.136  -4.939  1.00 95.11           C  \nATOM    396  CD2 LEU A  47     -27.114  -8.878  -5.568  1.00 95.11           C  \nATOM    397  N   GLU A  48     -24.441  -6.867  -9.384  1.00 97.04           N  \nATOM    398  CA  GLU A  48     -24.373  -7.405 -10.752  1.00 97.04           C  \nATOM    399  C   GLU A  48     -22.946  -7.429 -11.321  1.00 97.04           C  \nATOM    400  CB  GLU A  48     -25.305  -6.569 -11.650  1.00 97.04           C  \nATOM    401  O   GLU A  48     -22.599  -8.331 -12.077  1.00 97.04           O  \nATOM    402  CG  GLU A  48     -25.420  -7.100 -13.092  1.00 97.04           C  \nATOM    403  CD  GLU A  48     -26.362  -6.275 -13.990  1.00 97.04           C  \nATOM    404  OE1 GLU A  48     -26.570  -6.693 -15.153  1.00 97.04           O  \nATOM    405  OE2 GLU A  48     -26.867  -5.220 -13.540  1.00 97.04           O  \nATOM    406  N   THR A  49     -22.109  -6.448 -10.972  1.00 97.71           N  \nATOM    407  CA  THR A  49     -20.794  -6.249 -11.607  1.00 97.71           C  \nATOM    408  C   THR A  49     -19.604  -6.516 -10.687  1.00 97.71           C  \nATOM    409  CB  THR A  49     -20.689  -4.852 -12.230  1.00 97.71           C  \nATOM    410  O   THR A  49     -18.470  -6.523 -11.163  1.00 97.71           O  \nATOM    411  CG2 THR A  49     -21.639  -4.666 -13.412  1.00 97.71           C  \nATOM    412  OG1 THR A  49     -21.030  -3.848 -11.310  1.00 97.71           O  \nATOM    413  N   HIS A  50     -19.834  -6.760  -9.395  1.00 96.77           N  \nATOM    414  CA  HIS A  50     -18.790  -6.948  -8.383  1.00 96.77           C  \nATOM    415  C   HIS A  50     -17.804  -8.080  -8.711  1.00 96.77           C  \nATOM    416  CB  HIS A  50     -19.489  -7.231  -7.048  1.00 96.77           C  \nATOM    417  O   HIS A  50     -16.589  -7.945  -8.523  1.00 96.77           O  \nATOM    418  CG  HIS A  50     -18.541  -7.581  -5.935  1.00 96.77           C  \nATOM    419  CD2 HIS A  50     -18.244  -8.828  -5.458  1.00 96.77           C  \nATOM    420  ND1 HIS A  50     -17.826  -6.686  -5.187  1.00 96.77           N  \nATOM    421  CE1 HIS A  50     -17.138  -7.368  -4.265  1.00 96.77           C  \nATOM    422  NE2 HIS A  50     -17.340  -8.688  -4.398  1.00 96.77           N  \nATOM    423  N   GLU A  51     -18.307  -9.207  -9.223  1.00 94.57           N  \nATOM    424  CA  GLU A  51     -17.473 -10.370  -9.552  1.00 94.57           C  \nATOM    425  C   GLU A  51     -16.443 -10.045 -10.647  1.00 94.57           C  \nATOM    426  CB  GLU A  51     -18.371 -11.554  -9.946  1.00 94.57           C  \nATOM    427  O   GLU A  51     -15.287 -10.459 -10.548  1.00 94.57           O  \nATOM    428  CG  GLU A  51     -17.556 -12.851 -10.095  1.00 94.57           C  \nATOM    429  CD  GLU A  51     -18.408 -14.102 -10.372  1.00 94.57           C  \nATOM    430  OE1 GLU A  51     -17.795 -15.188 -10.498  1.00 94.57           O  \nATOM    431  OE2 GLU A  51     -19.653 -13.991 -10.425  1.00 94.57           O  \nATOM    432  N   GLU A  52     -16.818  -9.218 -11.623  1.00 95.46           N  \nATOM    433  CA  GLU A  52     -15.971  -8.824 -12.755  1.00 95.46           C  \nATOM    434  C   GLU A  52     -15.170  -7.536 -12.519  1.00 95.46           C  \nATOM    435  CB  GLU A  52     -16.848  -8.600 -13.988  1.00 95.46           C  \nATOM    436  O   GLU A  52     -14.249  -7.243 -13.279  1.00 95.46           O  \nATOM    437  CG  GLU A  52     -17.655  -9.819 -14.453  1.00 95.46           C  \nATOM    438  CD  GLU A  52     -18.460  -9.496 -15.724  1.00 95.46           C  \nATOM    439  OE1 GLU A  52     -18.987 -10.453 -16.335  1.00 95.46           O  \nATOM    440  OE2 GLU A  52     -18.514  -8.296 -16.104  1.00 95.46           O  \nATOM    441  N   ALA A  53     -15.531  -6.733 -11.515  1.00 97.22           N  \nATOM    442  CA  ALA A  53     -14.846  -5.479 -11.217  1.00 97.22           C  \nATOM    443  C   ALA A  53     -13.401  -5.738 -10.774  1.00 97.22           C  \nATOM    444  CB  ALA A  53     -15.625  -4.731 -10.133  1.00 97.22           C  \nATOM    445  O   ALA A  53     -13.153  -6.631  -9.953  1.00 97.22           O  \nATOM    446  N   SER A  54     -12.449  -4.941 -11.263  1.00 96.53           N  \nATOM    447  CA  SER A  54     -11.054  -5.056 -10.819  1.00 96.53           C  \nATOM    448  C   SER A  54     -10.874  -4.500  -9.400  1.00 96.53           C  \nATOM    449  CB  SER A  54     -10.129  -4.356 -11.821  1.00 96.53           C  \nATOM    450  O   SER A  54     -10.081  -5.009  -8.616  1.00 96.53           O  \nATOM    451  OG  SER A  54     -10.189  -2.952 -11.659  1.00 96.53           O  \nATOM    452  N   VAL A  55     -11.630  -3.453  -9.055  1.00 97.96           N  \nATOM    453  CA  VAL A  55     -11.655  -2.837  -7.722  1.00 97.96           C  \nATOM    454  C   VAL A  55     -12.819  -3.444  -6.946  1.00 97.96           C  \nATOM    455  CB  VAL A  55     -11.779  -1.305  -7.827  1.00 97.96           C  \nATOM    456  O   VAL A  55     -13.976  -3.197  -7.273  1.00 97.96           O  \nATOM    457  CG1 VAL A  55     -11.705  -0.649  -6.447  1.00 97.96           C  \nATOM    458  CG2 VAL A  55     -10.646  -0.705  -8.668  1.00 97.96           C  \nATOM    459  N   LYS A  56     -12.530  -4.278  -5.941  1.00 96.50           N  \nATOM    460  CA  LYS A  56     -13.550  -5.134  -5.313  1.00 96.50           C  \nATOM    461  C   LYS A  56     -14.473  -4.424  -4.333  1.00 96.50           C  \nATOM    462  CB  LYS A  56     -12.904  -6.376  -4.671  1.00 96.50           C  \nATOM    463  O   LYS A  56     -15.584  -4.899  -4.154  1.00 96.50           O  \nATOM    464  CG  LYS A  56     -12.315  -7.385  -5.673  1.00 96.50           C  \nATOM    465  CD  LYS A  56     -13.367  -7.817  -6.703  1.00 96.50           C  \nATOM    466  CE  LYS A  56     -12.935  -8.980  -7.592  1.00 96.50           C  \nATOM    467  NZ  LYS A  56     -13.856  -9.035  -8.747  1.00 96.50           N  \nATOM    468  N   MET A  57     -14.066  -3.310  -3.723  1.00 97.70           N  \nATOM    469  CA  MET A  57     -14.947  -2.531  -2.834  1.00 97.70           C  \nATOM    470  C   MET A  57     -15.571  -3.386  -1.714  1.00 97.70           C  \nATOM    471  CB  MET A  57     -16.010  -1.790  -3.662  1.00 97.70           C  \nATOM    472  O   MET A  57     -16.782  -3.403  -1.502  1.00 97.70           O  \nATOM    473  CG  MET A  57     -15.395  -0.943  -4.777  1.00 97.70           C  \nATOM    474  SD  MET A  57     -14.324   0.396  -4.201  1.00 97.70           S  \nATOM    475  CE  MET A  57     -15.610   1.486  -3.570  1.00 97.70           C  \nATOM    476  N   LEU A  58     -14.726  -4.130  -1.004  1.00 97.01           N  \nATOM    477  CA  LEU A  58     -15.116  -5.101   0.011  1.00 97.01           C  \nATOM    478  C   LEU A  58     -15.724  -4.408   1.251  1.00 97.01           C  \nATOM    479  CB  LEU A  58     -13.899  -5.967   0.387  1.00 97.01           C  \nATOM    480  O   LEU A  58     -15.044  -3.600   1.897  1.00 97.01           O  \nATOM    481  CG  LEU A  58     -13.298  -6.764  -0.787  1.00 97.01           C  \nATOM    482  CD1 LEU A  58     -12.066  -7.538  -0.324  1.00 97.01           C  \nATOM    483  CD2 LEU A  58     -14.282  -7.783  -1.368  1.00 97.01           C  \nATOM    484  N   PRO A  59     -16.971  -4.741   1.637  1.00 95.88           N  \nATOM    485  CA  PRO A  59     -17.580  -4.255   2.871  1.00 95.88           C  \nATOM    486  C   PRO A  59     -16.829  -4.772   4.102  1.00 95.88           C  \nATOM    487  CB  PRO A  59     -19.030  -4.756   2.850  1.00 95.88           C  \nATOM    488  O   PRO A  59     -16.488  -5.951   4.181  1.00 95.88           O  \nATOM    489  CG  PRO A  59     -19.295  -5.096   1.388  1.00 95.88           C  \nATOM    490  CD  PRO A  59     -17.930  -5.538   0.889  1.00 95.88           C  \nATOM    491  N   THR A  60     -16.590  -3.901   5.083  1.00 94.13           N  \nATOM    492  CA  THR A  60     -15.776  -4.238   6.271  1.00 94.13           C  \nATOM    493  C   THR A  60     -16.601  -4.481   7.534  1.00 94.13           C  \nATOM    494  CB  THR A  60     -14.750  -3.138   6.570  1.00 94.13           C  \nATOM    495  O   THR A  60     -16.049  -4.866   8.559  1.00 94.13           O  \nATOM    496  CG2 THR A  60     -13.894  -2.757   5.358  1.00 94.13           C  \nATOM    497  OG1 THR A  60     -15.425  -1.990   7.022  1.00 94.13           O  \nATOM    498  N   TYR A  61     -17.911  -4.207   7.490  1.00 91.04           N  \nATOM    499  CA  TYR A  61     -18.823  -4.220   8.645  1.00 91.04           C  \nATOM    500  C   TYR A  61     -18.483  -3.207   9.758  1.00 91.04           C  \nATOM    501  CB  TYR A  61     -19.043  -5.656   9.153  1.00 91.04           C  \nATOM    502  O   TYR A  61     -19.196  -3.114  10.759  1.00 91.04           O  \nATOM    503  CG  TYR A  61     -19.774  -6.539   8.160  1.00 91.04           C  \nATOM    504  CD1 TYR A  61     -21.134  -6.842   8.361  1.00 91.04           C  \nATOM    505  CD2 TYR A  61     -19.104  -7.046   7.030  1.00 91.04           C  \nATOM    506  CE1 TYR A  61     -21.821  -7.648   7.434  1.00 91.04           C  \nATOM    507  CE2 TYR A  61     -19.789  -7.843   6.096  1.00 91.04           C  \nATOM    508  OH  TYR A  61     -21.814  -8.925   5.407  1.00 91.04           O  \nATOM    509  CZ  TYR A  61     -21.149  -8.153   6.303  1.00 91.04           C  \nATOM    510  N   VAL A  62     -17.481  -2.344   9.558  1.00 91.59           N  \nATOM    511  CA  VAL A  62     -17.222  -1.187  10.424  1.00 91.59           C  \nATOM    512  C   VAL A  62     -18.175  -0.053  10.032  1.00 91.59           C  \nATOM    513  CB  VAL A  62     -15.738  -0.771  10.376  1.00 91.59           C  \nATOM    514  O   VAL A  62     -17.945   0.675   9.069  1.00 91.59           O  \nATOM    515  CG1 VAL A  62     -15.459   0.405  11.322  1.00 91.59           C  \nATOM    516  CG2 VAL A  62     -14.833  -1.935  10.802  1.00 91.59           C  \nATOM    517  N   ARG A  63     -19.286   0.073  10.770  1.00 87.26           N  \nATOM    518  CA  ARG A  63     -20.339   1.089  10.536  1.00 87.26           C  \nATOM    519  C   ARG A  63     -20.217   2.362  11.379  1.00 87.26           C  \nATOM    520  CB  ARG A  63     -21.736   0.472  10.719  1.00 87.26           C  \nATOM    521  O   ARG A  63     -20.993   3.294  11.211  1.00 87.26           O  \nATOM    522  CG  ARG A  63     -22.088  -0.584   9.661  1.00 87.26           C  \nATOM    523  CD  ARG A  63     -23.600  -0.862   9.701  1.00 87.26           C  \nATOM    524  NE  ARG A  63     -24.023  -1.873   8.709  1.00 87.26           N  \nATOM    525  NH1 ARG A  63     -26.202  -1.170   8.417  1.00 87.26           N  \nATOM    526  NH2 ARG A  63     -25.471  -2.943   7.295  1.00 87.26           N  \nATOM    527  CZ  ARG A  63     -25.223  -1.987   8.150  1.00 87.26           C  \nATOM    528  N   SER A  64     -19.302   2.396  12.341  1.00 76.94           N  \nATOM    529  CA  SER A  64     -19.133   3.550  13.224  1.00 76.94           C  \nATOM    530  C   SER A  64     -17.683   3.716  13.624  1.00 76.94           C  \nATOM    531  CB  SER A  64     -20.005   3.435  14.479  1.00 76.94           C  \nATOM    532  O   SER A  64     -16.933   2.746  13.721  1.00 76.94           O  \nATOM    533  OG  SER A  64     -19.666   2.271  15.213  1.00 76.94           O  \nATOM    534  N   THR A  65     -17.331   4.955  13.904  1.00 77.74           N  \nATOM    535  CA  THR A  65     -16.035   5.368  14.414  1.00 77.74           C  \nATOM    536  C   THR A  65     -16.079   5.503  15.945  1.00 77.74           C  \nATOM    537  CB  THR A  65     -15.667   6.687  13.740  1.00 77.74           C  \nATOM    538  O   THR A  65     -17.174   5.533  16.515  1.00 77.74           O  \nATOM    539  CG2 THR A  65     -15.401   6.501  12.244  1.00 77.74           C  \nATOM    540  OG1 THR A  65     -16.749   7.586  13.853  1.00 77.74           O  \nATOM    541  N   PRO A  66     -14.924   5.525  16.637  1.00 79.65           N  \nATOM    542  CA  PRO A  66     -14.876   5.750  18.081  1.00 79.65           C  \nATOM    543  C   PRO A  66     -15.467   7.112  18.462  1.00 79.65           C  \nATOM    544  CB  PRO A  66     -13.398   5.646  18.475  1.00 79.65           C  \nATOM    545  O   PRO A  66     -15.230   8.100  17.771  1.00 79.65           O  \nATOM    546  CG  PRO A  66     -12.774   4.842  17.337  1.00 79.65           C  \nATOM    547  CD  PRO A  66     -13.591   5.269  16.122  1.00 79.65           C  \nATOM    548  N   GLU A  67     -16.199   7.167  19.575  1.00 79.31           N  \nATOM    549  CA  GLU A  67     -16.833   8.391  20.097  1.00 79.31           C  \nATOM    550  C   GLU A  67     -16.007   9.057  21.213  1.00 79.31           C  \nATOM    551  CB  GLU A  67     -18.242   8.056  20.616  1.00 79.31           C  \nATOM    552  O   GLU A  67     -16.404  10.090  21.749  1.00 79.31           O  \nATOM    553  CG  GLU A  67     -19.219   7.584  19.525  1.00 79.31           C  \nATOM    554  CD  GLU A  67     -20.558   7.084  20.099  1.00 79.31           C  \nATOM    555  OE1 GLU A  67     -21.512   6.938  19.303  1.00 79.31           O  \nATOM    556  OE2 GLU A  67     -20.624   6.761  21.318  1.00 79.31           O  \nATOM    557  N   GLY A  68     -14.886   8.448  21.618  1.00 76.31           N  \nATOM    558  CA  GLY A  68     -14.038   8.944  22.706  1.00 76.31           C  \nATOM    559  C   GLY A  68     -14.556   8.575  24.098  1.00 76.31           C  \nATOM    560  O   GLY A  68     -14.277   9.278  25.062  1.00 76.31           O  \nATOM    561  N   SER A  69     -15.331   7.492  24.205  1.00 77.45           N  \nATOM    562  CA  SER A  69     -15.860   6.959  25.477  1.00 77.45           C  \nATOM    563  C   SER A  69     -15.552   5.466  25.691  1.00 77.45           C  \nATOM    564  CB  SER A  69     -17.353   7.265  25.621  1.00 77.45           C  \nATOM    565  O   SER A  69     -15.996   4.858  26.665  1.00 77.45           O  \nATOM    566  OG  SER A  69     -18.058   6.876  24.459  1.00 77.45           O  \nATOM    567  N   GLU A  70     -14.769   4.855  24.802  1.00 81.98           N  \nATOM    568  CA  GLU A  70     -14.397   3.437  24.791  1.00 81.98           C  \nATOM    569  C   GLU A  70     -13.254   3.054  25.764  1.00 81.98           C  \nATOM    570  CB  GLU A  70     -13.967   3.063  23.360  1.00 81.98           C  \nATOM    571  O   GLU A  70     -12.089   3.049  25.379  1.00 81.98           O  \nATOM    572  CG  GLU A  70     -15.023   3.168  22.256  1.00 81.98           C  \nATOM    573  CD  GLU A  70     -15.331   4.593  21.777  1.00 81.98           C  \nATOM    574  OE1 GLU A  70     -16.377   4.747  21.115  1.00 81.98           O  \nATOM    575  OE2 GLU A  70     -14.595   5.552  22.108  1.00 81.98           O  \nATOM    576  N   VAL A  71     -13.518   2.735  27.032  1.00 83.64           N  \nATOM    577  CA  VAL A  71     -12.443   2.400  27.997  1.00 83.64           C  \nATOM    578  C   VAL A  71     -12.064   0.913  27.945  1.00 83.64           C  \nATOM    579  CB  VAL A  71     -12.817   2.795  29.439  1.00 83.64           C  \nATOM    580  O   VAL A  71     -12.943   0.053  27.919  1.00 83.64           O  \nATOM    581  CG1 VAL A  71     -11.619   2.687  30.393  1.00 83.64           C  \nATOM    582  CG2 VAL A  71     -13.319   4.234  29.549  1.00 83.64           C  \nATOM    583  N   GLY A  72     -10.770   0.584  28.022  1.00 88.91           N  \nATOM    584  CA  GLY A  72     -10.309  -0.789  28.249  1.00 88.91           C  \nATOM    585  C   GLY A  72      -8.846  -1.065  27.890  1.00 88.91           C  \nATOM    586  O   GLY A  72      -8.173  -0.271  27.234  1.00 88.91           O  \nATOM    587  N   ASP A  73      -8.368  -2.236  28.315  1.00 92.05           N  \nATOM    588  CA  ASP A  73      -7.118  -2.832  27.840  1.00 92.05           C  \nATOM    589  C   ASP A  73      -7.459  -3.810  26.700  1.00 92.05           C  \nATOM    590  CB  ASP A  73      -6.383  -3.571  28.983  1.00 92.05           C  \nATOM    591  O   ASP A  73      -8.223  -4.757  26.895  1.00 92.05           O  \nATOM    592  CG  ASP A  73      -5.624  -2.716  30.018  1.00 92.05           C  \nATOM    593  OD1 ASP A  73      -5.597  -1.472  29.961  1.00 92.05           O  \nATOM    594  OD2 ASP A  73      -4.913  -3.303  30.879  1.00 92.05           O  \nATOM    595  N   PHE A  74      -6.861  -3.608  25.531  1.00 93.99           N  \nATOM    596  CA  PHE A  74      -7.079  -4.404  24.326  1.00 93.99           C  \nATOM    597  C   PHE A  74      -5.754  -4.954  23.833  1.00 93.99           C  \nATOM    598  CB  PHE A  74      -7.728  -3.539  23.239  1.00 93.99           C  \nATOM    599  O   PHE A  74      -4.723  -4.282  23.914  1.00 93.99           O  \nATOM    600  CG  PHE A  74      -9.064  -2.971  23.657  1.00 93.99           C  \nATOM    601  CD1 PHE A  74     -10.238  -3.707  23.430  1.00 93.99           C  \nATOM    602  CD2 PHE A  74      -9.127  -1.737  24.331  1.00 93.99           C  \nATOM    603  CE1 PHE A  74     -11.470  -3.238  23.917  1.00 93.99           C  \nATOM    604  CE2 PHE A  74     -10.361  -1.257  24.799  1.00 93.99           C  \nATOM    605  CZ  PHE A  74     -11.527  -2.018  24.615  1.00 93.99           C  \nATOM    606  N   LEU A  75      -5.773  -6.161  23.283  1.00 95.28           N  \nATOM    607  CA  LEU A  75      -4.649  -6.628  22.492  1.00 95.28           C  \nATOM    608  C   LEU A  75      -4.947  -6.369  21.013  1.00 95.28           C  \nATOM    609  CB  LEU A  75      -4.331  -8.085  22.851  1.00 95.28           C  \nATOM    610  O   LEU A  75      -6.089  -6.499  20.572  1.00 95.28           O  \nATOM    611  CG  LEU A  75      -2.882  -8.445  22.470  1.00 95.28           C  \nATOM    612  CD1 LEU A  75      -1.900  -8.001  23.553  1.00 95.28           C  \nATOM    613  CD2 LEU A  75      -2.681  -9.938  22.360  1.00 95.28           C  \nATOM    614  N   SER A  76      -3.931  -6.012  20.237  1.00 95.61           N  \nATOM    615  CA  SER A  76      -4.033  -5.981  18.787  1.00 95.61           C  \nATOM    616  C   SER A  76      -2.896  -6.725  18.111  1.00 95.61           C  \nATOM    617  CB  SER A  76      -4.230  -4.574  18.231  1.00 95.61           C  \nATOM    618  O   SER A  76      -1.756  -6.741  18.581  1.00 95.61           O  \nATOM    619  OG  SER A  76      -3.089  -3.765  18.374  1.00 95.61           O  \nATOM    620  N   LEU A  77      -3.244  -7.384  17.014  1.00 96.38           N  \nATOM    621  CA  LEU A  77      -2.316  -8.068  16.129  1.00 96.38           C  \nATOM    622  C   LEU A  77      -2.283  -7.327  14.804  1.00 96.38           C  \nATOM    623  CB  LEU A  77      -2.747  -9.521  15.897  1.00 96.38           C  \nATOM    624  O   LEU A  77      -3.315  -6.857  14.337  1.00 96.38           O  \nATOM    625  CG  LEU A  77      -3.104 -10.321  17.144  1.00 96.38           C  \nATOM    626  CD1 LEU A  77      -3.460 -11.745  16.730  1.00 96.38           C  \nATOM    627  CD2 LEU A  77      -1.993 -10.351  18.196  1.00 96.38           C  \nATOM    628  N   ASP A  78      -1.118  -7.268  14.185  1.00 95.07           N  \nATOM    629  CA  ASP A  78      -0.927  -6.636  12.888  1.00 95.07           C  \nATOM    630  C   ASP A  78      -0.044  -7.537  12.030  1.00 95.07           C  \nATOM    631  CB  ASP A  78      -0.362  -5.237  13.139  1.00 95.07           C  \nATOM    632  O   ASP A  78       1.164  -7.654  12.260  1.00 95.07           O  \nATOM    633  CG  ASP A  78       0.032  -4.477  11.881  1.00 95.07           C  \nATOM    634  OD1 ASP A  78      -0.519  -4.754  10.800  1.00 95.07           O  \nATOM    635  OD2 ASP A  78       0.832  -3.522  12.050  1.00 95.07           O  \nATOM    636  N   LEU A  79      -0.681  -8.242  11.093  1.00 93.13           N  \nATOM    637  CA  LEU A  79      -0.012  -9.096  10.120  1.00 93.13           C  \nATOM    638  C   LEU A  79       0.145  -8.339   8.800  1.00 93.13           C  \nATOM    639  CB  LEU A  79      -0.771 -10.425   9.972  1.00 93.13           C  \nATOM    640  O   LEU A  79      -0.722  -8.394   7.924  1.00 93.13           O  \nATOM    641  CG  LEU A  79      -0.013 -11.436   9.091  1.00 93.13           C  \nATOM    642  CD1 LEU A  79       1.190 -12.021   9.827  1.00 93.13           C  \nATOM    643  CD2 LEU A  79      -0.933 -12.586   8.706  1.00 93.13           C  \nATOM    644  N   GLY A  80       1.280  -7.652   8.675  1.00 85.19           N  \nATOM    645  CA  GLY A  80       1.659  -6.927   7.470  1.00 85.19           C  \nATOM    646  C   GLY A  80       2.419  -7.789   6.457  1.00 85.19           C  \nATOM    647  O   GLY A  80       2.668  -8.977   6.645  1.00 85.19           O  \nATOM    648  N   GLY A  81       2.875  -7.157   5.372  1.00 75.33           N  \nATOM    649  CA  GLY A  81       3.600  -7.838   4.290  1.00 75.33           C  \nATOM    650  C   GLY A  81       5.038  -8.277   4.616  1.00 75.33           C  \nATOM    651  O   GLY A  81       5.711  -8.816   3.743  1.00 75.33           O  \nATOM    652  N   THR A  82       5.557  -7.988   5.813  1.00 73.91           N  \nATOM    653  CA  THR A  82       6.976  -8.230   6.165  1.00 73.91           C  \nATOM    654  C   THR A  82       7.170  -8.543   7.645  1.00 73.91           C  \nATOM    655  CB  THR A  82       7.843  -7.008   5.798  1.00 73.91           C  \nATOM    656  O   THR A  82       7.963  -9.412   7.993  1.00 73.91           O  \nATOM    657  CG2 THR A  82       9.343  -7.261   5.950  1.00 73.91           C  \nATOM    658  OG1 THR A  82       7.611  -6.630   4.456  1.00 73.91           O  \nATOM    659  N   ASN A  83       6.440  -7.854   8.522  1.00 86.23           N  \nATOM    660  CA  ASN A  83       6.534  -8.038   9.964  1.00 86.23           C  \nATOM    661  C   ASN A  83       5.169  -8.405  10.533  1.00 86.23           C  \nATOM    662  CB  ASN A  83       7.091  -6.765  10.620  1.00 86.23           C  \nATOM    663  O   ASN A  83       4.136  -7.944  10.043  1.00 86.23           O  \nATOM    664  CG  ASN A  83       8.489  -6.420  10.141  1.00 86.23           C  \nATOM    665  ND2 ASN A  83       8.726  -5.183   9.773  1.00 86.23           N  \nATOM    666  OD1 ASN A  83       9.390  -7.238  10.093  1.00 86.23           O  \nATOM    667  N   PHE A  84       5.202  -9.186  11.602  1.00 93.95           N  \nATOM    668  CA  PHE A  84       4.079  -9.391  12.493  1.00 93.95           C  \nATOM    669  C   PHE A  84       4.289  -8.557  13.754  1.00 93.95           C  \nATOM    670  CB  PHE A  84       3.947 -10.882  12.805  1.00 93.95           C  \nATOM    671  O   PHE A  84       5.397  -8.501  14.291  1.00 93.95           O  \nATOM    672  CG  PHE A  84       2.811 -11.175  13.754  1.00 93.95           C  \nATOM    673  CD1 PHE A  84       3.058 -11.722  15.026  1.00 93.95           C  \nATOM    674  CD2 PHE A  84       1.497 -10.868  13.362  1.00 93.95           C  \nATOM    675  CE1 PHE A  84       1.982 -11.957  15.899  1.00 93.95           C  \nATOM    676  CE2 PHE A  84       0.427 -11.111  14.231  1.00 93.95           C  \nATOM    677  CZ  PHE A  84       0.672 -11.645  15.504  1.00 93.95           C  \nATOM    678  N   ARG A  85       3.247  -7.892  14.241  1.00 94.81           N  \nATOM    679  CA  ARG A  85       3.332  -7.064  15.443  1.00 94.81           C  \nATOM    680  C   ARG A  85       2.214  -7.413  16.412  1.00 94.81           C  \nATOM    681  CB  ARG A  85       3.386  -5.592  15.019  1.00 94.81           C  \nATOM    682  O   ARG A  85       1.058  -7.528  16.021  1.00 94.81           O  \nATOM    683  CG  ARG A  85       3.421  -4.616  16.203  1.00 94.81           C  \nATOM    684  CD  ARG A  85       3.621  -3.170  15.740  1.00 94.81           C  \nATOM    685  NE  ARG A  85       2.551  -2.727  14.831  1.00 94.81           N  \nATOM    686  NH1 ARG A  85       2.901  -0.465  15.004  1.00 94.81           N  \nATOM    687  NH2 ARG A  85       1.274  -1.265  13.703  1.00 94.81           N  \nATOM    688  CZ  ARG A  85       2.247  -1.485  14.525  1.00 94.81           C  \nATOM    689  N   VAL A  86       2.580  -7.543  17.683  1.00 95.89           N  \nATOM    690  CA  VAL A  86       1.651  -7.722  18.804  1.00 95.89           C  \nATOM    691  C   VAL A  86       1.692  -6.456  19.646  1.00 95.89           C  \nATOM    692  CB  VAL A  86       2.003  -8.958  19.655  1.00 95.89           C  \nATOM    693  O   VAL A  86       2.780  -5.970  19.970  1.00 95.89           O  \nATOM    694  CG1 VAL A  86       0.912  -9.222  20.701  1.00 95.89           C  \nATOM    695  CG2 VAL A  86       2.147 -10.224  18.803  1.00 95.89           C  \nATOM    696  N   MET A  87       0.529  -5.904  19.985  1.00 94.97           N  \nATOM    697  CA  MET A  87       0.415  -4.683  20.776  1.00 94.97           C  \nATOM    698  C   MET A  87      -0.579  -4.839  21.918  1.00 94.97           C  \nATOM    699  CB  MET A  87       0.029  -3.467  19.920  1.00 94.97           C  \nATOM    700  O   MET A  87      -1.655  -5.398  21.750  1.00 94.97           O  \nATOM    701  CG  MET A  87       0.864  -3.339  18.644  1.00 94.97           C  \nATOM    702  SD  MET A  87       0.705  -1.824  17.654  1.00 94.97           S  \nATOM    703  CE  MET A  87       0.605  -0.482  18.868  1.00 94.97           C  \nATOM    704  N   LEU A  88      -0.239  -4.282  23.074  1.00 94.38           N  \nATOM    705  CA  LEU A  88      -1.184  -3.960  24.134  1.00 94.38           C  \nATOM    706  C   LEU A  88      -1.552  -2.487  23.998  1.00 94.38           C  \nATOM    707  CB  LEU A  88      -0.542  -4.265  25.494  1.00 94.38           C  \nATOM    708  O   LEU A  88      -0.677  -1.623  24.088  1.00 94.38           O  \nATOM    709  CG  LEU A  88      -1.435  -3.908  26.697  1.00 94.38           C  \nATOM    710  CD1 LEU A  88      -2.645  -4.832  26.821  1.00 94.38           C  \nATOM    711  CD2 LEU A  88      -0.604  -4.001  27.979  1.00 94.38           C  \nATOM    712  N   VAL A  89      -2.836  -2.211  23.826  1.00 92.51           N  \nATOM    713  CA  VAL A  89      -3.389  -0.868  23.693  1.00 92.51           C  \nATOM    714  C   VAL A  89      -4.299  -0.605  24.881  1.00 92.51           C  \nATOM    715  CB  VAL A  89      -4.144  -0.711  22.363  1.00 92.51           C  \nATOM    716  O   VAL A  89      -5.257  -1.334  25.120  1.00 92.51           O  \nATOM    717  CG1 VAL A  89      -4.593   0.742  22.180  1.00 92.51           C  \nATOM    718  CG2 VAL A  89      -3.265  -1.101  21.165  1.00 92.51           C  \nATOM    719  N   LYS A  90      -3.989   0.436  25.645  1.00 90.91           N  \nATOM    720  CA  LYS A  90      -4.807   0.892  26.766  1.00 90.91           C  \nATOM    721  C   LYS A  90      -5.536   2.152  26.353  1.00 90.91           C  \nATOM    722  CB  LYS A  90      -3.947   1.139  28.001  1.00 90.91           C  \nATOM    723  O   LYS A  90      -4.880   3.149  26.052  1.00 90.91           O  \nATOM    724  CG  LYS A  90      -3.127  -0.098  28.367  1.00 90.91           C  \nATOM    725  CD  LYS A  90      -2.585   0.066  29.783  1.00 90.91           C  \nATOM    726  CE  LYS A  90      -2.041  -1.277  30.255  1.00 90.91           C  \nATOM    727  NZ  LYS A  90      -2.758  -1.692  31.472  1.00 90.91           N  \nATOM    728  N   VAL A  91      -6.858   2.088  26.338  1.00 87.42           N  \nATOM    729  CA  VAL A  91      -7.745   3.178  25.941  1.00 87.42           C  \nATOM    730  C   VAL A  91      -8.497   3.657  27.181  1.00 87.42           C  \nATOM    731  CB  VAL A  91      -8.708   2.713  24.828  1.00 87.42           C  \nATOM    732  O   VAL A  91      -9.071   2.846  27.907  1.00 87.42           O  \nATOM    733  CG1 VAL A  91      -9.447   3.918  24.253  1.00 87.42           C  \nATOM    734  CG2 VAL A  91      -7.986   2.032  23.655  1.00 87.42           C  \nATOM    735  N   GLY A  92      -8.473   4.957  27.466  1.00 83.02           N  \nATOM    736  CA  GLY A  92      -9.228   5.527  28.583  1.00 83.02           C  \nATOM    737  C   GLY A  92      -8.793   6.936  28.972  1.00 83.02           C  \nATOM    738  O   GLY A  92      -7.907   7.524  28.350  1.00 83.02           O  \nATOM    739  N   GLU A  93      -9.405   7.467  30.030  1.00 67.59           N  \nATOM    740  CA  GLU A  93      -9.097   8.799  30.558  1.00 67.59           C  \nATOM    741  C   GLU A  93      -7.637   8.892  31.036  1.00 67.59           C  \nATOM    742  CB  GLU A  93     -10.073   9.182  31.683  1.00 67.59           C  \nATOM    743  O   GLU A  93      -7.160   8.097  31.850  1.00 67.59           O  \nATOM    744  CG  GLU A  93     -11.504   9.412  31.162  1.00 67.59           C  \nATOM    745  CD  GLU A  93     -12.493   9.859  32.256  1.00 67.59           C  \nATOM    746  OE1 GLU A  93     -13.673  10.080  31.905  1.00 67.59           O  \nATOM    747  OE2 GLU A  93     -12.086   9.947  33.438  1.00 67.59           O  \nATOM    748  N   GLY A  94      -6.906   9.858  30.484  1.00 63.49           N  \nATOM    749  CA  GLY A  94      -5.564  10.235  30.909  1.00 63.49           C  \nATOM    750  C   GLY A  94      -5.568  11.108  32.168  1.00 63.49           C  \nATOM    751  O   GLY A  94      -6.610  11.432  32.732  1.00 63.49           O  \nATOM    752  N   GLU A  95      -4.376  11.519  32.605  1.00 60.01           N  \nATOM    753  CA  GLU A  95      -4.169  12.233  33.880  1.00 60.01           C  \nATOM    754  C   GLU A  95      -4.857  13.610  33.942  1.00 60.01           C  \nATOM    755  CB  GLU A  95      -2.655  12.364  34.144  1.00 60.01           C  \nATOM    756  O   GLU A  95      -5.232  14.056  35.023  1.00 60.01           O  \nATOM    757  CG  GLU A  95      -2.016  10.999  34.460  1.00 60.01           C  \nATOM    758  CD  GLU A  95      -0.484  11.015  34.594  1.00 60.01           C  \nATOM    759  OE1 GLU A  95       0.085   9.894  34.546  1.00 60.01           O  \nATOM    760  OE2 GLU A  95       0.116  12.104  34.706  1.00 60.01           O  \nATOM    761  N   GLU A  96      -5.076  14.261  32.797  1.00 61.24           N  \nATOM    762  CA  GLU A  96      -5.698  15.592  32.699  1.00 61.24           C  \nATOM    763  C   GLU A  96      -7.176  15.542  32.264  1.00 61.24           C  \nATOM    764  CB  GLU A  96      -4.857  16.499  31.783  1.00 61.24           C  \nATOM    765  O   GLU A  96      -7.721  16.532  31.780  1.00 61.24           O  \nATOM    766  CG  GLU A  96      -3.432  16.721  32.318  1.00 61.24           C  \nATOM    767  CD  GLU A  96      -2.623  17.735  31.490  1.00 61.24           C  \nATOM    768  OE1 GLU A  96      -1.516  18.093  31.955  1.00 61.24           O  \nATOM    769  OE2 GLU A  96      -3.105  18.160  30.415  1.00 61.24           O  \nATOM    770  N   GLY A  97      -7.827  14.376  32.362  1.00 58.18           N  \nATOM    771  CA  GLY A  97      -9.180  14.163  31.826  1.00 58.18           C  \nATOM    772  C   GLY A  97      -9.241  14.126  30.292  1.00 58.18           C  \nATOM    773  O   GLY A  97     -10.313  13.956  29.719  1.00 58.18           O  \nATOM    774  N   GLN A  98      -8.097  14.260  29.612  1.00 64.07           N  \nATOM    775  CA  GLN A  98      -7.980  14.019  28.178  1.00 64.07           C  \nATOM    776  C   GLN A  98      -7.915  12.522  27.916  1.00 64.07           C  \nATOM    777  CB  GLN A  98      -6.740  14.699  27.590  1.00 64.07           C  \nATOM    778  O   GLN A  98      -7.146  11.802  28.554  1.00 64.07           O  \nATOM    779  CG  GLN A  98      -6.845  16.228  27.634  1.00 64.07           C  \nATOM    780  CD  GLN A  98      -5.653  16.912  26.973  1.00 64.07           C  \nATOM    781  NE2 GLN A  98      -5.462  18.187  27.212  1.00 64.07           N  \nATOM    782  OE1 GLN A  98      -4.873  16.329  26.239  1.00 64.07           O  \nATOM    783  N   TRP A  99      -8.696  12.052  26.955  1.00 69.84           N  \nATOM    784  CA  TRP A  99      -8.648  10.664  26.529  1.00 69.84           C  \nATOM    785  C   TRP A  99      -7.264  10.308  25.981  1.00 69.84           C  \nATOM    786  CB  TRP A  99      -9.739  10.436  25.498  1.00 69.84           C  \nATOM    787  O   TRP A  99      -6.682  11.051  25.188  1.00 69.84           O  \nATOM    788  CG  TRP A  99     -10.150   9.015  25.386  1.00 69.84           C  \nATOM    789  CD1 TRP A  99      -9.580   8.013  24.675  1.00 69.84           C  \nATOM    790  CD2 TRP A  99     -11.203   8.393  26.155  1.00 69.84           C  \nATOM    791  CE2 TRP A  99     -11.328   7.061  25.701  1.00 69.84           C  \nATOM    792  CE3 TRP A  99     -12.035   8.802  27.216  1.00 69.84           C  \nATOM    793  NE1 TRP A  99     -10.362   6.896  24.752  1.00 69.84           N  \nATOM    794  CH2 TRP A  99     -13.103   6.625  27.263  1.00 69.84           C  \nATOM    795  CZ2 TRP A  99     -12.271   6.206  26.224  1.00 69.84           C  \nATOM    796  CZ3 TRP A  99     -12.973   7.920  27.776  1.00 69.84           C  \nATOM    797  N   SER A 100      -6.716   9.176  26.417  1.00 78.58           N  \nATOM    798  CA  SER A 100      -5.363   8.749  26.077  1.00 78.58           C  \nATOM    799  C   SER A 100      -5.345   7.323  25.543  1.00 78.58           C  \nATOM    800  CB  SER A 100      -4.414   8.943  27.268  1.00 78.58           C  \nATOM    801  O   SER A 100      -6.096   6.453  25.990  1.00 78.58           O  \nATOM    802  OG  SER A 100      -4.623   7.989  28.295  1.00 78.58           O  \nATOM    803  N   VAL A 101      -4.451   7.088  24.584  1.00 82.75           N  \nATOM    804  CA  VAL A 101      -4.159   5.758  24.055  1.00 82.75           C  \nATOM    805  C   VAL A 101      -2.692   5.457  24.334  1.00 82.75           C  \nATOM    806  CB  VAL A 101      -4.513   5.643  22.562  1.00 82.75           C  \nATOM    807  O   VAL A 101      -1.807   6.075  23.749  1.00 82.75           O  \nATOM    808  CG1 VAL A 101      -4.293   4.201  22.105  1.00 82.75           C  \nATOM    809  CG2 VAL A 101      -5.985   5.997  22.300  1.00 82.75           C  \nATOM    810  N   LYS A 102      -2.423   4.536  25.264  1.00 86.97           N  \nATOM    811  CA  LYS A 102      -1.056   4.106  25.604  1.00 86.97           C  \nATOM    812  C   LYS A 102      -0.782   2.746  24.979  1.00 86.97           C  \nATOM    813  CB  LYS A 102      -0.831   4.095  27.128  1.00 86.97           C  \nATOM    814  O   LYS A 102      -1.544   1.807  25.209  1.00 86.97           O  \nATOM    815  CG  LYS A 102      -0.908   5.500  27.749  1.00 86.97           C  \nATOM    816  CD  LYS A 102      -0.643   5.494  29.266  1.00 86.97           C  \nATOM    817  CE  LYS A 102      -0.780   6.930  29.805  1.00 86.97           C  \nATOM    818  NZ  LYS A 102      -0.582   7.047  31.278  1.00 86.97           N  \nATOM    819  N   THR A 103       0.319   2.621  24.244  1.00 90.69           N  \nATOM    820  CA  THR A 103       0.684   1.382  23.552  1.00 90.69           C  \nATOM    821  C   THR A 103       1.960   0.762  24.123  1.00 90.69           C  \nATOM    822  CB  THR A 103       0.774   1.580  22.028  1.00 90.69           C  \nATOM    823  O   THR A 103       2.858   1.438  24.628  1.00 90.69           O  \nATOM    824  CG2 THR A 103      -0.538   2.111  21.447  1.00 90.69           C  \nATOM    825  OG1 THR A 103       1.787   2.495  21.715  1.00 90.69           O  \nATOM    826  N   LYS A 104       2.033  -0.568  24.075  1.00 92.29           N  \nATOM    827  CA  LYS A 104       3.275  -1.346  24.165  1.00 92.29           C  \nATOM    828  C   LYS A 104       3.258  -2.337  23.021  1.00 92.29           C  \nATOM    829  CB  LYS A 104       3.378  -2.110  25.491  1.00 92.29           C  \nATOM    830  O   LYS A 104       2.251  -3.019  22.861  1.00 92.29           O  \nATOM    831  CG  LYS A 104       3.511  -1.192  26.706  1.00 92.29           C  \nATOM    832  CD  LYS A 104       3.719  -2.047  27.958  1.00 92.29           C  \nATOM    833  CE  LYS A 104       3.883  -1.142  29.178  1.00 92.29           C  \nATOM    834  NZ  LYS A 104       4.209  -1.941  30.384  1.00 92.29           N  \nATOM    835  N   HIS A 105       4.337  -2.449  22.260  1.00 93.29           N  \nATOM    836  CA  HIS A 105       4.371  -3.336  21.104  1.00 93.29           C  \nATOM    837  C   HIS A 105       5.654  -4.157  21.033  1.00 93.29           C  \nATOM    838  CB  HIS A 105       4.129  -2.526  19.823  1.00 93.29           C  \nATOM    839  O   HIS A 105       6.687  -3.784  21.587  1.00 93.29           O  \nATOM    840  CG  HIS A 105       5.251  -1.604  19.433  1.00 93.29           C  \nATOM    841  CD2 HIS A 105       6.396  -1.977  18.783  1.00 93.29           C  \nATOM    842  ND1 HIS A 105       5.304  -0.236  19.591  1.00 93.29           N  \nATOM    843  CE1 HIS A 105       6.458   0.191  19.059  1.00 93.29           C  \nATOM    844  NE2 HIS A 105       7.160  -0.835  18.551  1.00 93.29           N  \nATOM    845  N   GLN A 106       5.584  -5.267  20.304  1.00 94.47           N  \nATOM    846  CA  GLN A 106       6.743  -6.044  19.890  1.00 94.47           C  \nATOM    847  C   GLN A 106       6.576  -6.468  18.432  1.00 94.47           C  \nATOM    848  CB  GLN A 106       6.920  -7.238  20.833  1.00 94.47           C  \nATOM    849  O   GLN A 106       5.506  -6.925  18.029  1.00 94.47           O  \nATOM    850  CG  GLN A 106       8.252  -7.964  20.603  1.00 94.47           C  \nATOM    851  CD  GLN A 106       8.509  -9.058  21.633  1.00 94.47           C  \nATOM    852  NE2 GLN A 106       9.227 -10.094  21.258  1.00 94.47           N  \nATOM    853  OE1 GLN A 106       8.106  -9.006  22.784  1.00 94.47           O  \nATOM    854  N   MET A 107       7.638  -6.292  17.646  1.00 93.56           N  \nATOM    855  CA  MET A 107       7.704  -6.727  16.252  1.00 93.56           C  \nATOM    856  C   MET A 107       8.435  -8.064  16.138  1.00 93.56           C  \nATOM    857  CB  MET A 107       8.395  -5.671  15.380  1.00 93.56           C  \nATOM    858  O   MET A 107       9.413  -8.310  16.845  1.00 93.56           O  \nATOM    859  CG  MET A 107       7.578  -4.381  15.261  1.00 93.56           C  \nATOM    860  SD  MET A 107       8.280  -3.169  14.108  1.00 93.56           S  \nATOM    861  CE  MET A 107       9.740  -2.627  15.039  1.00 93.56           C  \nATOM    862  N   TYR A 108       7.973  -8.885  15.205  1.00 95.20           N  \nATOM    863  CA  TYR A 108       8.491 -10.202  14.874  1.00 95.20           C  \nATOM    864  C   TYR A 108       8.672 -10.292  13.355  1.00 95.20           C  \nATOM    865  CB  TYR A 108       7.512 -11.272  15.380  1.00 95.20           C  \nATOM    866  O   TYR A 108       7.773  -9.935  12.591  1.00 95.20           O  \nATOM    867  CG  TYR A 108       7.264 -11.252  16.878  1.00 95.20           C  \nATOM    868  CD1 TYR A 108       8.013 -12.092  17.725  1.00 95.20           C  \nATOM    869  CD2 TYR A 108       6.263 -10.420  17.417  1.00 95.20           C  \nATOM    870  CE1 TYR A 108       7.751 -12.112  19.108  1.00 95.20           C  \nATOM    871  CE2 TYR A 108       6.013 -10.423  18.801  1.00 95.20           C  \nATOM    872  OH  TYR A 108       6.503 -11.261  20.978  1.00 95.20           O  \nATOM    873  CZ  TYR A 108       6.747 -11.277  19.646  1.00 95.20           C  \nATOM    874  N   SER A 109       9.839 -10.753  12.908  1.00 92.97           N  \nATOM    875  CA  SER A 109      10.088 -11.039  11.491  1.00 92.97           C  \nATOM    876  C   SER A 109       9.464 -12.378  11.130  1.00 92.97           C  \nATOM    877  CB  SER A 109      11.588 -11.117  11.200  1.00 92.97           C  \nATOM    878  O   SER A 109       9.809 -13.381  11.746  1.00 92.97           O  \nATOM    879  OG  SER A 109      12.216  -9.884  11.488  1.00 92.97           O  \nATOM    880  N   ILE A 110       8.595 -12.406  10.124  1.00 90.72           N  \nATOM    881  CA  ILE A 110       7.926 -13.642   9.707  1.00 90.72           C  \nATOM    882  C   ILE A 110       8.910 -14.476   8.868  1.00 90.72           C  \nATOM    883  CB  ILE A 110       6.621 -13.350   8.941  1.00 90.72           C  \nATOM    884  O   ILE A 110       9.429 -13.961   7.875  1.00 90.72           O  \nATOM    885  CG1 ILE A 110       5.714 -12.380   9.735  1.00 90.72           C  \nATOM    886  CG2 ILE A 110       5.868 -14.669   8.678  1.00 90.72           C  \nATOM    887  CD1 ILE A 110       4.573 -11.818   8.890  1.00 90.72           C  \nATOM    888  N   PRO A 111       9.189 -15.737   9.239  1.00 91.62           N  \nATOM    889  CA  PRO A 111      10.029 -16.629   8.445  1.00 91.62           C  \nATOM    890  C   PRO A 111       9.454 -16.893   7.042  1.00 91.62           C  \nATOM    891  CB  PRO A 111      10.124 -17.910   9.275  1.00 91.62           C  \nATOM    892  O   PRO A 111       8.239 -16.995   6.866  1.00 91.62           O  \nATOM    893  CG  PRO A 111       9.904 -17.450  10.709  1.00 91.62           C  \nATOM    894  CD  PRO A 111       8.857 -16.363  10.511  1.00 91.62           C  \nATOM    895  N   GLU A 112      10.317 -17.031   6.032  1.00 89.42           N  \nATOM    896  CA  GLU A 112       9.898 -17.234   4.632  1.00 89.42           C  \nATOM    897  C   GLU A 112       9.109 -18.541   4.432  1.00 89.42           C  \nATOM    898  CB  GLU A 112      11.150 -17.205   3.737  1.00 89.42           C  \nATOM    899  O   GLU A 112       8.141 -18.589   3.667  1.00 89.42           O  \nATOM    900  CG  GLU A 112      10.818 -17.260   2.235  1.00 89.42           C  \nATOM    901  CD  GLU A 112      12.053 -17.140   1.324  1.00 89.42           C  \nATOM    902  OE1 GLU A 112      11.845 -17.074   0.090  1.00 89.42           O  \nATOM    903  OE2 GLU A 112      13.192 -17.104   1.845  1.00 89.42           O  \nATOM    904  N   ASP A 113       9.471 -19.591   5.166  1.00 91.72           N  \nATOM    905  CA  ASP A 113       8.769 -20.873   5.193  1.00 91.72           C  \nATOM    906  C   ASP A 113       7.382 -20.766   5.841  1.00 91.72           C  \nATOM    907  CB  ASP A 113       9.643 -21.929   5.896  1.00 91.72           C  \nATOM    908  O   ASP A 113       6.448 -21.422   5.384  1.00 91.72           O  \nATOM    909  CG  ASP A 113       9.973 -21.619   7.363  1.00 91.72           C  \nATOM    910  OD1 ASP A 113      10.089 -20.419   7.695  1.00 91.72           O  \nATOM    911  OD2 ASP A 113      10.148 -22.587   8.132  1.00 91.72           O  \nATOM    912  N   ALA A 114       7.192 -19.887   6.829  1.00 92.79           N  \nATOM    913  CA  ALA A 114       5.863 -19.575   7.359  1.00 92.79           C  \nATOM    914  C   ALA A 114       5.014 -18.782   6.345  1.00 92.79           C  \nATOM    915  CB  ALA A 114       6.013 -18.838   8.695  1.00 92.79           C  \nATOM    916  O   ALA A 114       3.817 -19.027   6.213  1.00 92.79           O  \nATOM    917  N   MET A 115       5.620 -17.867   5.579  1.00 89.91           N  \nATOM    918  CA  MET A 115       4.913 -17.082   4.551  1.00 89.91           C  \nATOM    919  C   MET A 115       4.460 -17.925   3.349  1.00 89.91           C  \nATOM    920  CB  MET A 115       5.811 -15.945   4.039  1.00 89.91           C  \nATOM    921  O   MET A 115       3.453 -17.602   2.712  1.00 89.91           O  \nATOM    922  CG  MET A 115       6.109 -14.894   5.111  1.00 89.91           C  \nATOM    923  SD  MET A 115       7.233 -13.560   4.611  1.00 89.91           S  \nATOM    924  CE  MET A 115       6.362 -12.886   3.176  1.00 89.91           C  \nATOM    925  N   THR A 116       5.212 -18.975   3.010  1.00 91.53           N  \nATOM    926  CA  THR A 116       5.031 -19.771   1.780  1.00 91.53           C  \nATOM    927  C   THR A 116       4.622 -21.226   2.019  1.00 91.53           C  \nATOM    928  CB  THR A 116       6.292 -19.721   0.903  1.00 91.53           C  \nATOM    929  O   THR A 116       4.306 -21.928   1.060  1.00 91.53           O  \nATOM    930  CG2 THR A 116       6.633 -18.301   0.447  1.00 91.53           C  \nATOM    931  OG1 THR A 116       7.406 -20.237   1.591  1.00 91.53           O  \nATOM    932  N   GLY A 117       4.601 -21.679   3.275  1.00 93.72           N  \nATOM    933  CA  GLY A 117       4.248 -23.038   3.676  1.00 93.72           C  \nATOM    934  C   GLY A 117       2.739 -23.283   3.742  1.00 93.72           C  \nATOM    935  O   GLY A 117       2.009 -23.126   2.761  1.00 93.72           O  \nATOM    936  N   THR A 118       2.253 -23.721   4.902  1.00 96.96           N  \nATOM    937  CA  THR A 118       0.822 -23.972   5.144  1.00 96.96           C  \nATOM    938  C   THR A 118       0.217 -22.896   6.039  1.00 96.96           C  \nATOM    939  CB  THR A 118       0.571 -25.363   5.744  1.00 96.96           C  \nATOM    940  O   THR A 118       0.921 -22.227   6.794  1.00 96.96           O  \nATOM    941  CG2 THR A 118       1.183 -26.497   4.923  1.00 96.96           C  \nATOM    942  OG1 THR A 118       1.105 -25.439   7.041  1.00 96.96           O  \nATOM    943  N   ALA A 119      -1.107 -22.748   5.988  1.00 96.77           N  \nATOM    944  CA  ALA A 119      -1.842 -21.903   6.919  1.00 96.77           C  \nATOM    945  C   ALA A 119      -1.529 -22.282   8.373  1.00 96.77           C  \nATOM    946  CB  ALA A 119      -3.337 -22.044   6.619  1.00 96.77           C  \nATOM    947  O   ALA A 119      -1.260 -21.406   9.186  1.00 96.77           O  \nATOM    948  N   GLU A 120      -1.486 -23.580   8.690  1.00 97.51           N  \nATOM    949  CA  GLU A 120      -1.136 -24.060  10.030  1.00 97.51           C  \nATOM    950  C   GLU A 120       0.232 -23.533  10.483  1.00 97.51           C  \nATOM    951  CB  GLU A 120      -1.211 -25.594  10.061  1.00 97.51           C  \nATOM    952  O   GLU A 120       0.312 -22.933  11.549  1.00 97.51           O  \nATOM    953  CG  GLU A 120      -0.963 -26.155  11.467  1.00 97.51           C  \nATOM    954  CD  GLU A 120      -1.308 -27.648  11.542  1.00 97.51           C  \nATOM    955  OE1 GLU A 120      -0.373 -28.478  11.591  1.00 97.51           O  \nATOM    956  OE2 GLU A 120      -2.524 -27.956  11.528  1.00 97.51           O  \nATOM    957  N   MET A 121       1.271 -23.635   9.643  1.00 96.57           N  \nATOM    958  CA  MET A 121       2.605 -23.103   9.962  1.00 96.57           C  \nATOM    959  C   MET A 121       2.583 -21.595  10.248  1.00 96.57           C  \nATOM    960  CB  MET A 121       3.578 -23.374   8.806  1.00 96.57           C  \nATOM    961  O   MET A 121       3.187 -21.142  11.221  1.00 96.57           O  \nATOM    962  CG  MET A 121       3.945 -24.853   8.660  1.00 96.57           C  \nATOM    963  SD  MET A 121       4.807 -25.246   7.108  1.00 96.57           S  \nATOM    964  CE  MET A 121       6.349 -24.311   7.349  1.00 96.57           C  \nATOM    965  N   LEU A 122       1.876 -20.813   9.425  1.00 96.86           N  \nATOM    966  CA  LEU A 122       1.774 -19.363   9.602  1.00 96.86           C  \nATOM    967  C   LEU A 122       1.052 -18.994  10.905  1.00 96.86           C  \nATOM    968  CB  LEU A 122       1.067 -18.753   8.377  1.00 96.86           C  \nATOM    969  O   LEU A 122       1.539 -18.163  11.672  1.00 96.86           O  \nATOM    970  CG  LEU A 122       0.884 -17.224   8.447  1.00 96.86           C  \nATOM    971  CD1 LEU A 122       2.209 -16.465   8.572  1.00 96.86           C  \nATOM    972  CD2 LEU A 122       0.167 -16.738   7.187  1.00 96.86           C  \nATOM    973  N   PHE A 123      -0.111 -19.595  11.164  1.00 97.37           N  \nATOM    974  CA  PHE A 123      -0.923 -19.254  12.333  1.00 97.37           C  \nATOM    975  C   PHE A 123      -0.349 -19.825  13.639  1.00 97.37           C  \nATOM    976  CB  PHE A 123      -2.394 -19.627  12.094  1.00 97.37           C  \nATOM    977  O   PHE A 123      -0.483 -19.184  14.683  1.00 97.37           O  \nATOM    978  CG  PHE A 123      -3.096 -18.705  11.108  1.00 97.37           C  \nATOM    979  CD1 PHE A 123      -3.516 -17.425  11.517  1.00 97.37           C  \nATOM    980  CD2 PHE A 123      -3.329 -19.105   9.780  1.00 97.37           C  \nATOM    981  CE1 PHE A 123      -4.135 -16.556  10.599  1.00 97.37           C  \nATOM    982  CE2 PHE A 123      -3.905 -18.226   8.850  1.00 97.37           C  \nATOM    983  CZ  PHE A 123      -4.313 -16.950   9.261  1.00 97.37           C  \nATOM    984  N   ASP A 124       0.362 -20.954  13.598  1.00 97.60           N  \nATOM    985  CA  ASP A 124       1.089 -21.490  14.755  1.00 97.60           C  \nATOM    986  C   ASP A 124       2.281 -20.594  15.134  1.00 97.60           C  \nATOM    987  CB  ASP A 124       1.547 -22.934  14.488  1.00 97.60           C  \nATOM    988  O   ASP A 124       2.507 -20.352  16.328  1.00 97.60           O  \nATOM    989  CG  ASP A 124       0.421 -23.981  14.569  1.00 97.60           C  \nATOM    990  OD1 ASP A 124      -0.773 -23.623  14.738  1.00 97.60           O  \nATOM    991  OD2 ASP A 124       0.747 -25.184  14.551  1.00 97.60           O  \nATOM    992  N   TYR A 125       2.981 -20.032  14.137  1.00 96.76           N  \nATOM    993  CA  TYR A 125       4.011 -19.008  14.343  1.00 96.76           C  \nATOM    994  C   TYR A 125       3.419 -17.724  14.943  1.00 96.76           C  \nATOM    995  CB  TYR A 125       4.731 -18.714  13.017  1.00 96.76           C  \nATOM    996  O   TYR A 125       3.923 -17.213  15.942  1.00 96.76           O  \nATOM    997  CG  TYR A 125       5.762 -17.611  13.144  1.00 96.76           C  \nATOM    998  CD1 TYR A 125       5.441 -16.288  12.774  1.00 96.76           C  \nATOM    999  CD2 TYR A 125       7.012 -17.900  13.720  1.00 96.76           C  \nATOM   1000  CE1 TYR A 125       6.360 -15.250  13.015  1.00 96.76           C  \nATOM   1001  CE2 TYR A 125       7.939 -16.869  13.950  1.00 96.76           C  \nATOM   1002  OH  TYR A 125       8.469 -14.538  13.899  1.00 96.76           O  \nATOM   1003  CZ  TYR A 125       7.600 -15.540  13.621  1.00 96.76           C  \nATOM   1004  N   ILE A 126       2.296 -17.234  14.404  1.00 96.63           N  \nATOM   1005  CA  ILE A 126       1.570 -16.081  14.968  1.00 96.63           C  \nATOM   1006  C   ILE A 126       1.200 -16.339  16.437  1.00 96.63           C  \nATOM   1007  CB  ILE A 126       0.329 -15.767  14.099  1.00 96.63           C  \nATOM   1008  O   ILE A 126       1.434 -15.488  17.297  1.00 96.63           O  \nATOM   1009  CG1 ILE A 126       0.767 -15.108  12.772  1.00 96.63           C  \nATOM   1010  CG2 ILE A 126      -0.685 -14.881  14.843  1.00 96.63           C  \nATOM   1011  CD1 ILE A 126      -0.345 -15.053  11.714  1.00 96.63           C  \nATOM   1012  N   SER A 127       0.672 -17.527  16.746  1.00 96.46           N  \nATOM   1013  CA  SER A 127       0.353 -17.945  18.115  1.00 96.46           C  \nATOM   1014  C   SER A 127       1.592 -17.963  19.025  1.00 96.46           C  \nATOM   1015  CB  SER A 127      -0.320 -19.321  18.066  1.00 96.46           C  \nATOM   1016  O   SER A 127       1.500 -17.594  20.197  1.00 96.46           O  \nATOM   1017  OG  SER A 127      -0.643 -19.767  19.368  1.00 96.46           O  \nATOM   1018  N   GLU A 128       2.765 -18.328  18.497  1.00 96.97           N  \nATOM   1019  CA  GLU A 128       4.042 -18.264  19.223  1.00 96.97           C  \nATOM   1020  C   GLU A 128       4.414 -16.844  19.618  1.00 96.97           C  \nATOM   1021  CB  GLU A 128       5.185 -18.847  18.375  1.00 96.97           C  \nATOM   1022  O   GLU A 128       4.709 -16.579  20.783  1.00 96.97           O  \nATOM   1023  CG  GLU A 128       6.360 -19.253  19.273  1.00 96.97           C  \nATOM   1024  CD  GLU A 128       7.435 -20.027  18.506  1.00 96.97           C  \nATOM   1025  OE1 GLU A 128       8.624 -19.867  18.858  1.00 96.97           O  \nATOM   1026  OE2 GLU A 128       7.040 -20.847  17.650  1.00 96.97           O  \nATOM   1027  N   CYS A 129       4.354 -15.923  18.658  1.00 96.98           N  \nATOM   1028  CA  CYS A 129       4.657 -14.518  18.886  1.00 96.98           C  \nATOM   1029  C   CYS A 129       3.718 -13.908  19.933  1.00 96.98           C  \nATOM   1030  CB  CYS A 129       4.526 -13.785  17.552  1.00 96.98           C  \nATOM   1031  O   CYS A 129       4.158 -13.163  20.807  1.00 96.98           O  \nATOM   1032  SG  CYS A 129       5.733 -14.396  16.350  1.00 96.98           S  \nATOM   1033  N   ILE A 130       2.431 -14.260  19.885  1.00 96.16           N  \nATOM   1034  CA  ILE A 130       1.457 -13.840  20.895  1.00 96.16           C  \nATOM   1035  C   ILE A 130       1.848 -14.375  22.278  1.00 96.16           C  \nATOM   1036  CB  ILE A 130       0.046 -14.301  20.492  1.00 96.16           C  \nATOM   1037  O   ILE A 130       1.899 -13.603  23.235  1.00 96.16           O  \nATOM   1038  CG1 ILE A 130      -0.430 -13.587  19.210  1.00 96.16           C  \nATOM   1039  CG2 ILE A 130      -0.940 -14.026  21.632  1.00 96.16           C  \nATOM   1040  CD1 ILE A 130      -1.670 -14.239  18.585  1.00 96.16           C  \nATOM   1041  N   SER A 131       2.147 -15.673  22.386  1.00 96.18           N  \nATOM   1042  CA  SER A 131       2.564 -16.310  23.643  1.00 96.18           C  \nATOM   1043  C   SER A 131       3.792 -15.620  24.251  1.00 96.18           C  \nATOM   1044  CB  SER A 131       2.868 -17.793  23.400  1.00 96.18           C  \nATOM   1045  O   SER A 131       3.763 -15.239  25.424  1.00 96.18           O  \nATOM   1046  OG  SER A 131       3.160 -18.439  24.622  1.00 96.18           O  \nATOM   1047  N   ASP A 132       4.830 -15.381  23.441  1.00 96.99           N  \nATOM   1048  CA  ASP A 132       6.058 -14.683  23.844  1.00 96.99           C  \nATOM   1049  C   ASP A 132       5.769 -13.265  24.360  1.00 96.99           C  \nATOM   1050  CB  ASP A 132       7.029 -14.648  22.648  1.00 96.99           C  \nATOM   1051  O   ASP A 132       6.261 -12.866  25.421  1.00 96.99           O  \nATOM   1052  CG  ASP A 132       8.243 -13.737  22.881  1.00 96.99           C  \nATOM   1053  OD1 ASP A 132       9.141 -14.044  23.691  1.00 96.99           O  \nATOM   1054  OD2 ASP A 132       8.328 -12.651  22.254  1.00 96.99           O  \nATOM   1055  N   PHE A 133       4.926 -12.506  23.653  1.00 96.58           N  \nATOM   1056  CA  PHE A 133       4.532 -11.167  24.085  1.00 96.58           C  \nATOM   1057  C   PHE A 133       3.782 -11.198  25.423  1.00 96.58           C  \nATOM   1058  CB  PHE A 133       3.666 -10.507  23.008  1.00 96.58           C  \nATOM   1059  O   PHE A 133       4.070 -10.393  26.318  1.00 96.58           O  \nATOM   1060  CG  PHE A 133       3.266  -9.090  23.367  1.00 96.58           C  \nATOM   1061  CD1 PHE A 133       2.033  -8.829  23.992  1.00 96.58           C  \nATOM   1062  CD2 PHE A 133       4.147  -8.032  23.097  1.00 96.58           C  \nATOM   1063  CE1 PHE A 133       1.680  -7.509  24.325  1.00 96.58           C  \nATOM   1064  CE2 PHE A 133       3.787  -6.709  23.409  1.00 96.58           C  \nATOM   1065  CZ  PHE A 133       2.552  -6.448  24.025  1.00 96.58           C  \nATOM   1066  N   LEU A 134       2.827 -12.122  25.580  1.00 95.45           N  \nATOM   1067  CA  LEU A 134       2.046 -12.272  26.807  1.00 95.45           C  \nATOM   1068  C   LEU A 134       2.920 -12.694  27.994  1.00 95.45           C  \nATOM   1069  CB  LEU A 134       0.905 -13.283  26.592  1.00 95.45           C  \nATOM   1070  O   LEU A 134       2.705 -12.181  29.093  1.00 95.45           O  \nATOM   1071  CG  LEU A 134      -0.225 -12.839  25.646  1.00 95.45           C  \nATOM   1072  CD1 LEU A 134      -1.221 -13.989  25.507  1.00 95.45           C  \nATOM   1073  CD2 LEU A 134      -0.981 -11.611  26.158  1.00 95.45           C  \nATOM   1074  N   ASP A 135       3.913 -13.564  27.795  1.00 94.75           N  \nATOM   1075  CA  ASP A 135       4.872 -13.958  28.837  1.00 94.75           C  \nATOM   1076  C   ASP A 135       5.711 -12.773  29.313  1.00 94.75           C  \nATOM   1077  CB  ASP A 135       5.812 -15.067  28.327  1.00 94.75           C  \nATOM   1078  O   ASP A 135       5.769 -12.487  30.512  1.00 94.75           O  \nATOM   1079  CG  ASP A 135       5.280 -16.476  28.570  1.00 94.75           C  \nATOM   1080  OD1 ASP A 135       4.409 -16.649  29.451  1.00 94.75           O  \nATOM   1081  OD2 ASP A 135       5.734 -17.419  27.890  1.00 94.75           O  \nATOM   1082  N   LYS A 136       6.301 -12.023  28.374  1.00 95.77           N  \nATOM   1083  CA  LYS A 136       7.128 -10.841  28.676  1.00 95.77           C  \nATOM   1084  C   LYS A 136       6.385  -9.780  29.482  1.00 95.77           C  \nATOM   1085  CB  LYS A 136       7.628 -10.244  27.357  1.00 95.77           C  \nATOM   1086  O   LYS A 136       6.996  -9.058  30.268  1.00 95.77           O  \nATOM   1087  CG  LYS A 136       8.795 -11.069  26.813  1.00 95.77           C  \nATOM   1088  CD  LYS A 136       9.121 -10.660  25.380  1.00 95.77           C  \nATOM   1089  CE  LYS A 136      10.383 -11.399  24.946  1.00 95.77           C  \nATOM   1090  NZ  LYS A 136      10.460 -11.481  23.480  1.00 95.77           N  \nATOM   1091  N   HIS A 137       5.070  -9.704  29.309  1.00 93.86           N  \nATOM   1092  CA  HIS A 137       4.209  -8.747  29.994  1.00 93.86           C  \nATOM   1093  C   HIS A 137       3.412  -9.356  31.157  1.00 93.86           C  \nATOM   1094  CB  HIS A 137       3.322  -8.073  28.948  1.00 93.86           C  \nATOM   1095  O   HIS A 137       2.634  -8.638  31.785  1.00 93.86           O  \nATOM   1096  CG  HIS A 137       4.116  -7.244  27.972  1.00 93.86           C  \nATOM   1097  CD2 HIS A 137       4.439  -5.924  28.100  1.00 93.86           C  \nATOM   1098  ND1 HIS A 137       4.693  -7.688  26.809  1.00 93.86           N  \nATOM   1099  CE1 HIS A 137       5.351  -6.660  26.250  1.00 93.86           C  \nATOM   1100  NE2 HIS A 137       5.219  -5.550  27.004  1.00 93.86           N  \nATOM   1101  N   GLN A 138       3.608 -10.644  31.467  1.00 93.11           N  \nATOM   1102  CA  GLN A 138       2.908 -11.377  32.529  1.00 93.11           C  \nATOM   1103  C   GLN A 138       1.377 -11.333  32.374  1.00 93.11           C  \nATOM   1104  CB  GLN A 138       3.384 -10.916  33.920  1.00 93.11           C  \nATOM   1105  O   GLN A 138       0.643 -11.119  33.337  1.00 93.11           O  \nATOM   1106  CG  GLN A 138       4.904 -11.018  34.104  1.00 93.11           C  \nATOM   1107  CD  GLN A 138       5.374 -10.412  35.420  1.00 93.11           C  \nATOM   1108  NE2 GLN A 138       6.639 -10.069  35.521  1.00 93.11           N  \nATOM   1109  OE1 GLN A 138       4.641 -10.223  36.377  1.00 93.11           O  \nATOM   1110  N   MET A 139       0.880 -11.518  31.149  1.00 91.67           N  \nATOM   1111  CA  MET A 139      -0.540 -11.371  30.803  1.00 91.67           C  \nATOM   1112  C   MET A 139      -1.224 -12.661  30.339  1.00 91.67           C  \nATOM   1113  CB  MET A 139      -0.733 -10.254  29.766  1.00 91.67           C  \nATOM   1114  O   MET A 139      -2.409 -12.607  30.039  1.00 91.67           O  \nATOM   1115  CG  MET A 139      -0.239  -8.898  30.271  1.00 91.67           C  \nATOM   1116  SD  MET A 139      -0.804  -7.467  29.317  1.00 91.67           S  \nATOM   1117  CE  MET A 139      -0.148  -7.887  27.674  1.00 91.67           C  \nATOM   1118  N   LYS A 140      -0.552 -13.822  30.325  1.00 90.85           N  \nATOM   1119  CA  LYS A 140      -1.161 -15.094  29.866  1.00 90.85           C  \nATOM   1120  C   LYS A 140      -2.451 -15.496  30.588  1.00 90.85           C  \nATOM   1121  CB  LYS A 140      -0.158 -16.250  29.987  1.00 90.85           C  \nATOM   1122  O   LYS A 140      -3.299 -16.161  30.011  1.00 90.85           O  \nATOM   1123  CG  LYS A 140       0.869 -16.224  28.855  1.00 90.85           C  \nATOM   1124  CD  LYS A 140       1.590 -17.570  28.759  1.00 90.85           C  \nATOM   1125  CE  LYS A 140       2.455 -17.531  27.503  1.00 90.85           C  \nATOM   1126  NZ  LYS A 140       3.405 -18.656  27.438  1.00 90.85           N  \nATOM   1127  N   HIS A 141      -2.607 -15.081  31.843  1.00 89.02           N  \nATOM   1128  CA  HIS A 141      -3.799 -15.353  32.650  1.00 89.02           C  \nATOM   1129  C   HIS A 141      -4.969 -14.394  32.360  1.00 89.02           C  \nATOM   1130  CB  HIS A 141      -3.401 -15.313  34.133  1.00 89.02           C  \nATOM   1131  O   HIS A 141      -6.046 -14.558  32.931  1.00 89.02           O  \nATOM   1132  CG  HIS A 141      -2.929 -13.953  34.590  1.00 89.02           C  \nATOM   1133  CD2 HIS A 141      -3.707 -12.958  35.121  1.00 89.02           C  \nATOM   1134  ND1 HIS A 141      -1.640 -13.470  34.533  1.00 89.02           N  \nATOM   1135  CE1 HIS A 141      -1.644 -12.221  35.028  1.00 89.02           C  \nATOM   1136  NE2 HIS A 141      -2.884 -11.857  35.387  1.00 89.02           N  \nATOM   1137  N   LYS A 142      -4.764 -13.362  31.531  1.00 88.35           N  \nATOM   1138  CA  LYS A 142      -5.791 -12.380  31.178  1.00 88.35           C  \nATOM   1139  C   LYS A 142      -6.439 -12.750  29.852  1.00 88.35           C  \nATOM   1140  CB  LYS A 142      -5.203 -10.967  31.080  1.00 88.35           C  \nATOM   1141  O   LYS A 142      -5.751 -12.922  28.852  1.00 88.35           O  \nATOM   1142  CG  LYS A 142      -4.638 -10.457  32.410  1.00 88.35           C  \nATOM   1143  CD  LYS A 142      -4.281  -8.977  32.261  1.00 88.35           C  \nATOM   1144  CE  LYS A 142      -3.834  -8.400  33.602  1.00 88.35           C  \nATOM   1145  NZ  LYS A 142      -3.636  -6.936  33.485  1.00 88.35           N  \nATOM   1146  N   LYS A 143      -7.769 -12.754  29.831  1.00 88.59           N  \nATOM   1147  CA  LYS A 143      -8.562 -12.848  28.605  1.00 88.59           C  \nATOM   1148  C   LYS A 143      -8.906 -11.439  28.128  1.00 88.59           C  \nATOM   1149  CB  LYS A 143      -9.781 -13.732  28.888  1.00 88.59           C  \nATOM   1150  O   LYS A 143      -9.872 -10.848  28.602  1.00 88.59           O  \nATOM   1151  CG  LYS A 143     -10.524 -14.105  27.600  1.00 88.59           C  \nATOM   1152  CD  LYS A 143     -11.547 -15.199  27.917  1.00 88.59           C  \nATOM   1153  CE  LYS A 143     -12.169 -15.751  26.636  1.00 88.59           C  \nATOM   1154  NZ  LYS A 143     -12.660 -17.130  26.866  1.00 88.59           N  \nATOM   1155  N   LEU A 144      -8.053 -10.874  27.275  1.00 90.45           N  \nATOM   1156  CA  LEU A 144      -8.263  -9.543  26.696  1.00 90.45           C  \nATOM   1157  C   LEU A 144      -9.009  -9.651  25.356  1.00 90.45           C  \nATOM   1158  CB  LEU A 144      -6.925  -8.802  26.519  1.00 90.45           C  \nATOM   1159  O   LEU A 144      -8.735 -10.594  24.604  1.00 90.45           O  \nATOM   1160  CG  LEU A 144      -6.157  -8.521  27.823  1.00 90.45           C  \nATOM   1161  CD1 LEU A 144      -4.837  -7.818  27.500  1.00 90.45           C  \nATOM   1162  CD2 LEU A 144      -6.939  -7.637  28.798  1.00 90.45           C  \nATOM   1163  N   PRO A 145      -9.888  -8.688  25.023  1.00 93.29           N  \nATOM   1164  CA  PRO A 145     -10.429  -8.575  23.677  1.00 93.29           C  \nATOM   1165  C   PRO A 145      -9.300  -8.293  22.680  1.00 93.29           C  \nATOM   1166  CB  PRO A 145     -11.464  -7.447  23.713  1.00 93.29           C  \nATOM   1167  O   PRO A 145      -8.414  -7.469  22.936  1.00 93.29           O  \nATOM   1168  CG  PRO A 145     -11.717  -7.194  25.198  1.00 93.29           C  \nATOM   1169  CD  PRO A 145     -10.413  -7.621  25.864  1.00 93.29           C  \nATOM   1170  N   LEU A 146      -9.336  -8.991  21.549  1.00 94.81           N  \nATOM   1171  CA  LEU A 146      -8.313  -8.976  20.515  1.00 94.81           C  \nATOM   1172  C   LEU A 146      -8.862  -8.355  19.229  1.00 94.81           C  \nATOM   1173  CB  LEU A 146      -7.815 -10.415  20.290  1.00 94.81           C  \nATOM   1174  O   LEU A 146      -9.843  -8.845  18.670  1.00 94.81           O  \nATOM   1175  CG  LEU A 146      -6.631 -10.525  19.312  1.00 94.81           C  \nATOM   1176  CD1 LEU A 146      -5.394  -9.971  20.000  1.00 94.81           C  \nATOM   1177  CD2 LEU A 146      -6.361 -11.979  18.916  1.00 94.81           C  \nATOM   1178  N   GLY A 147      -8.204  -7.301  18.750  1.00 95.81           N  \nATOM   1179  CA  GLY A 147      -8.372  -6.796  17.387  1.00 95.81           C  \nATOM   1180  C   GLY A 147      -7.305  -7.369  16.462  1.00 95.81           C  \nATOM   1181  O   GLY A 147      -6.125  -7.355  16.805  1.00 95.81           O  \nATOM   1182  N   PHE A 148      -7.686  -7.860  15.290  1.00 96.33           N  \nATOM   1183  CA  PHE A 148      -6.737  -8.404  14.323  1.00 96.33           C  \nATOM   1184  C   PHE A 148      -6.710  -7.569  13.043  1.00 96.33           C  \nATOM   1185  CB  PHE A 148      -7.054  -9.884  14.067  1.00 96.33           C  \nATOM   1186  O   PHE A 148      -7.629  -7.628  12.233  1.00 96.33           O  \nATOM   1187  CG  PHE A 148      -6.043 -10.653  13.228  1.00 96.33           C  \nATOM   1188  CD1 PHE A 148      -6.383 -11.938  12.766  1.00 96.33           C  \nATOM   1189  CD2 PHE A 148      -4.762 -10.139  12.929  1.00 96.33           C  \nATOM   1190  CE1 PHE A 148      -5.450 -12.704  12.045  1.00 96.33           C  \nATOM   1191  CE2 PHE A 148      -3.834 -10.901  12.207  1.00 96.33           C  \nATOM   1192  CZ  PHE A 148      -4.172 -12.191  11.772  1.00 96.33           C  \nATOM   1193  N   THR A 149      -5.630  -6.821  12.837  1.00 96.08           N  \nATOM   1194  CA  THR A 149      -5.325  -6.211  11.546  1.00 96.08           C  \nATOM   1195  C   THR A 149      -4.693  -7.240  10.617  1.00 96.08           C  \nATOM   1196  CB  THR A 149      -4.450  -4.965  11.675  1.00 96.08           C  \nATOM   1197  O   THR A 149      -3.586  -7.728  10.859  1.00 96.08           O  \nATOM   1198  CG2 THR A 149      -4.217  -4.332  10.309  1.00 96.08           C  \nATOM   1199  OG1 THR A 149      -5.159  -4.026  12.435  1.00 96.08           O  \nATOM   1200  N   PHE A 150      -5.408  -7.563   9.545  1.00 95.11           N  \nATOM   1201  CA  PHE A 150      -4.999  -8.516   8.527  1.00 95.11           C  \nATOM   1202  C   PHE A 150      -4.970  -7.819   7.163  1.00 95.11           C  \nATOM   1203  CB  PHE A 150      -5.940  -9.721   8.593  1.00 95.11           C  \nATOM   1204  O   PHE A 150      -5.999  -7.538   6.554  1.00 95.11           O  \nATOM   1205  CG  PHE A 150      -5.504 -10.878   7.726  1.00 95.11           C  \nATOM   1206  CD1 PHE A 150      -6.120 -11.085   6.485  1.00 95.11           C  \nATOM   1207  CD2 PHE A 150      -4.518 -11.776   8.175  1.00 95.11           C  \nATOM   1208  CE1 PHE A 150      -5.802 -12.219   5.726  1.00 95.11           C  \nATOM   1209  CE2 PHE A 150      -4.177 -12.898   7.397  1.00 95.11           C  \nATOM   1210  CZ  PHE A 150      -4.821 -13.121   6.169  1.00 95.11           C  \nATOM   1211  N   SER A 151      -3.763  -7.510   6.690  1.00 91.12           N  \nATOM   1212  CA  SER A 151      -3.502  -6.617   5.552  1.00 91.12           C  \nATOM   1213  C   SER A 151      -3.790  -7.205   4.159  1.00 91.12           C  \nATOM   1214  CB  SER A 151      -2.034  -6.189   5.621  1.00 91.12           C  \nATOM   1215  O   SER A 151      -3.229  -6.718   3.172  1.00 91.12           O  \nATOM   1216  OG  SER A 151      -1.750  -5.412   6.754  1.00 91.12           O  \nATOM   1217  N   PHE A 152      -4.583  -8.269   4.051  1.00 92.53           N  \nATOM   1218  CA  PHE A 152      -4.833  -8.985   2.794  1.00 92.53           C  \nATOM   1219  C   PHE A 152      -6.312  -8.903   2.393  1.00 92.53           C  \nATOM   1220  CB  PHE A 152      -4.361 -10.441   2.913  1.00 92.53           C  \nATOM   1221  O   PHE A 152      -7.150  -8.660   3.266  1.00 92.53           O  \nATOM   1222  CG  PHE A 152      -2.912 -10.590   3.322  1.00 92.53           C  \nATOM   1223  CD1 PHE A 152      -1.904 -10.635   2.343  1.00 92.53           C  \nATOM   1224  CD2 PHE A 152      -2.572 -10.648   4.686  1.00 92.53           C  \nATOM   1225  CE1 PHE A 152      -0.559 -10.757   2.731  1.00 92.53           C  \nATOM   1226  CE2 PHE A 152      -1.226 -10.744   5.072  1.00 92.53           C  \nATOM   1227  CZ  PHE A 152      -0.223 -10.803   4.094  1.00 92.53           C  \nATOM   1228  N   PRO A 153      -6.644  -9.130   1.107  1.00 93.17           N  \nATOM   1229  CA  PRO A 153      -8.023  -9.109   0.630  1.00 93.17           C  \nATOM   1230  C   PRO A 153      -8.895 -10.139   1.356  1.00 93.17           C  \nATOM   1231  CB  PRO A 153      -7.957  -9.383  -0.878  1.00 93.17           C  \nATOM   1232  O   PRO A 153      -8.706 -11.352   1.225  1.00 93.17           O  \nATOM   1233  CG  PRO A 153      -6.537  -8.994  -1.269  1.00 93.17           C  \nATOM   1234  CD  PRO A 153      -5.728  -9.301  -0.015  1.00 93.17           C  \nATOM   1235  N   VAL A 154      -9.874  -9.656   2.118  1.00 95.00           N  \nATOM   1236  CA  VAL A 154     -10.784 -10.488   2.909  1.00 95.00           C  \nATOM   1237  C   VAL A 154     -12.225 -10.116   2.608  1.00 95.00           C  \nATOM   1238  CB  VAL A 154     -10.484 -10.364   4.413  1.00 95.00           C  \nATOM   1239  O   VAL A 154     -12.623  -8.960   2.740  1.00 95.00           O  \nATOM   1240  CG1 VAL A 154     -11.575 -11.009   5.267  1.00 95.00           C  \nATOM   1241  CG2 VAL A 154      -9.184 -11.090   4.775  1.00 95.00           C  \nATOM   1242  N   ARG A 155     -13.038 -11.122   2.279  1.00 94.21           N  \nATOM   1243  CA  ARG A 155     -14.493 -10.980   2.264  1.00 94.21           C  \nATOM   1244  C   ARG A 155     -15.014 -11.188   3.679  1.00 94.21           C  \nATOM   1245  CB  ARG A 155     -15.103 -11.949   1.248  1.00 94.21           C  \nATOM   1246  O   ARG A 155     -14.997 -12.311   4.189  1.00 94.21           O  \nATOM   1247  CG  ARG A 155     -16.630 -11.800   1.156  1.00 94.21           C  \nATOM   1248  CD  ARG A 155     -17.236 -12.737   0.100  1.00 94.21           C  \nATOM   1249  NE  ARG A 155     -17.040 -14.169   0.425  1.00 94.21           N  \nATOM   1250  NH1 ARG A 155     -18.614 -14.358   2.106  1.00 94.21           N  \nATOM   1251  NH2 ARG A 155     -17.379 -16.089   1.640  1.00 94.21           N  \nATOM   1252  CZ  ARG A 155     -17.673 -14.854   1.366  1.00 94.21           C  \nATOM   1253  N   HIS A 156     -15.466 -10.110   4.305  1.00 92.55           N  \nATOM   1254  CA  HIS A 156     -16.102 -10.180   5.612  1.00 92.55           C  \nATOM   1255  C   HIS A 156     -17.515 -10.758   5.501  1.00 92.55           C  \nATOM   1256  CB  HIS A 156     -16.083  -8.808   6.286  1.00 92.55           C  \nATOM   1257  O   HIS A 156     -18.271 -10.441   4.584  1.00 92.55           O  \nATOM   1258  CG  HIS A 156     -14.714  -8.445   6.791  1.00 92.55           C  \nATOM   1259  CD2 HIS A 156     -13.663  -7.940   6.069  1.00 92.55           C  \nATOM   1260  ND1 HIS A 156     -14.278  -8.634   8.079  1.00 92.55           N  \nATOM   1261  CE1 HIS A 156     -12.992  -8.252   8.134  1.00 92.55           C  \nATOM   1262  NE2 HIS A 156     -12.565  -7.834   6.931  1.00 92.55           N  \nATOM   1263  N   GLU A 157     -17.849 -11.623   6.449  1.00 89.34           N  \nATOM   1264  CA  GLU A 157     -19.216 -12.085   6.709  1.00 89.34           C  \nATOM   1265  C   GLU A 157     -19.757 -11.481   8.011  1.00 89.34           C  \nATOM   1266  CB  GLU A 157     -19.236 -13.621   6.764  1.00 89.34           C  \nATOM   1267  O   GLU A 157     -20.966 -11.379   8.174  1.00 89.34           O  \nATOM   1268  CG  GLU A 157     -18.929 -14.235   5.390  1.00 89.34           C  \nATOM   1269  CD  GLU A 157     -18.975 -15.768   5.344  1.00 89.34           C  \nATOM   1270  OE1 GLU A 157     -18.757 -16.292   4.222  1.00 89.34           O  \nATOM   1271  OE2 GLU A 157     -19.204 -16.421   6.392  1.00 89.34           O  \nATOM   1272  N   ASP A 158     -18.858 -11.077   8.913  1.00 88.25           N  \nATOM   1273  CA  ASP A 158     -19.132 -10.303  10.123  1.00 88.25           C  \nATOM   1274  C   ASP A 158     -17.843  -9.559  10.547  1.00 88.25           C  \nATOM   1275  CB  ASP A 158     -19.638 -11.246  11.236  1.00 88.25           C  \nATOM   1276  O   ASP A 158     -16.779  -9.727   9.935  1.00 88.25           O  \nATOM   1277  CG  ASP A 158     -20.550 -10.549  12.258  1.00 88.25           C  \nATOM   1278  OD1 ASP A 158     -20.465  -9.303  12.380  1.00 88.25           O  \nATOM   1279  OD2 ASP A 158     -21.333 -11.271  12.912  1.00 88.25           O  \nATOM   1280  N   ILE A 159     -17.902  -8.761  11.615  1.00 88.43           N  \nATOM   1281  CA  ILE A 159     -16.758  -8.007  12.144  1.00 88.43           C  \nATOM   1282  C   ILE A 159     -15.617  -8.913  12.633  1.00 88.43           C  \nATOM   1283  CB  ILE A 159     -17.232  -7.020  13.233  1.00 88.43           C  \nATOM   1284  O   ILE A 159     -14.456  -8.522  12.552  1.00 88.43           O  \nATOM   1285  CG1 ILE A 159     -16.140  -5.964  13.514  1.00 88.43           C  \nATOM   1286  CG2 ILE A 159     -17.670  -7.741  14.523  1.00 88.43           C  \nATOM   1287  CD1 ILE A 159     -16.657  -4.740  14.279  1.00 88.43           C  \nATOM   1288  N   ASP A 160     -15.907 -10.134  13.093  1.00 89.61           N  \nATOM   1289  CA  ASP A 160     -14.925 -11.126  13.557  1.00 89.61           C  \nATOM   1290  C   ASP A 160     -14.847 -12.372  12.649  1.00 89.61           C  \nATOM   1291  CB  ASP A 160     -15.194 -11.490  15.030  1.00 89.61           C  \nATOM   1292  O   ASP A 160     -14.254 -13.391  13.017  1.00 89.61           O  \nATOM   1293  CG  ASP A 160     -16.297 -12.545  15.194  1.00 89.61           C  \nATOM   1294  OD1 ASP A 160     -17.256 -12.506  14.393  1.00 89.61           O  \nATOM   1295  OD2 ASP A 160     -16.128 -13.445  16.060  1.00 89.61           O  \nATOM   1296  N   LYS A 161     -15.427 -12.305  11.444  1.00 92.80           N  \nATOM   1297  CA  LYS A 161     -15.452 -13.417  10.489  1.00 92.80           C  \nATOM   1298  C   LYS A 161     -15.117 -12.928   9.092  1.00 92.80           C  \nATOM   1299  CB  LYS A 161     -16.830 -14.088  10.545  1.00 92.80           C  \nATOM   1300  O   LYS A 161     -15.904 -12.228   8.459  1.00 92.80           O  \nATOM   1301  CG  LYS A 161     -16.839 -15.405   9.759  1.00 92.80           C  \nATOM   1302  CD  LYS A 161     -18.239 -16.017   9.781  1.00 92.80           C  \nATOM   1303  CE  LYS A 161     -18.228 -17.384   9.094  1.00 92.80           C  \nATOM   1304  NZ  LYS A 161     -19.588 -17.745   8.644  1.00 92.80           N  \nATOM   1305  N   GLY A 162     -13.975 -13.362   8.571  1.00 94.95           N  \nATOM   1306  CA  GLY A 162     -13.576 -13.003   7.218  1.00 94.95           C  \nATOM   1307  C   GLY A 162     -12.820 -14.110   6.509  1.00 94.95           C  \nATOM   1308  O   GLY A 162     -11.969 -14.791   7.086  1.00 94.95           O  \nATOM   1309  N   ILE A 163     -13.182 -14.286   5.244  1.00 97.38           N  \nATOM   1310  CA  ILE A 163     -12.644 -15.297   4.348  1.00 97.38           C  \nATOM   1311  C   ILE A 163     -11.537 -14.663   3.514  1.00 97.38           C  \nATOM   1312  CB  ILE A 163     -13.776 -15.880   3.474  1.00 97.38           C  \nATOM   1313  O   ILE A 163     -11.797 -13.709   2.777  1.00 97.38           O  \nATOM   1314  CG1 ILE A 163     -14.998 -16.363   4.292  1.00 97.38           C  \nATOM   1315  CG2 ILE A 163     -13.227 -17.025   2.613  1.00 97.38           C  \nATOM   1316  CD1 ILE A 163     -14.693 -17.337   5.439  1.00 97.38           C  \nATOM   1317  N   LEU A 164     -10.312 -15.185   3.620  1.00 96.73           N  \nATOM   1318  CA  LEU A 164      -9.215 -14.743   2.759  1.00 96.73           C  \nATOM   1319  C   LEU A 164      -9.559 -15.075   1.304  1.00 96.73           C  \nATOM   1320  CB  LEU A 164      -7.898 -15.400   3.209  1.00 96.73           C  \nATOM   1321  O   LEU A 164      -9.832 -16.233   0.987  1.00 96.73           O  \nATOM   1322  CG  LEU A 164      -6.719 -15.139   2.251  1.00 96.73           C  \nATOM   1323  CD1 LEU A 164      -6.249 -13.688   2.226  1.00 96.73           C  \nATOM   1324  CD2 LEU A 164      -5.515 -15.969   2.662  1.00 96.73           C  \nATOM   1325  N   LEU A 165      -9.533 -14.074   0.427  1.00 94.26           N  \nATOM   1326  CA  LEU A 165      -9.818 -14.265  -0.995  1.00 94.26           C  \nATOM   1327  C   LEU A 165      -8.589 -14.794  -1.728  1.00 94.26           C  \nATOM   1328  CB  LEU A 165     -10.316 -12.945  -1.606  1.00 94.26           C  \nATOM   1329  O   LEU A 165      -8.634 -15.856  -2.341  1.00 94.26           O  \nATOM   1330  CG  LEU A 165     -11.676 -12.475  -1.066  1.00 94.26           C  \nATOM   1331  CD1 LEU A 165     -12.042 -11.139  -1.709  1.00 94.26           C  \nATOM   1332  CD2 LEU A 165     -12.778 -13.496  -1.369  1.00 94.26           C  \nATOM   1333  N   ASN A 166      -7.486 -14.063  -1.622  1.00 91.65           N  \nATOM   1334  CA  ASN A 166      -6.234 -14.385  -2.281  1.00 91.65           C  \nATOM   1335  C   ASN A 166      -5.067 -13.754  -1.522  1.00 91.65           C  \nATOM   1336  CB  ASN A 166      -6.291 -13.911  -3.744  1.00 91.65           C  \nATOM   1337  O   ASN A 166      -5.181 -12.656  -0.972  1.00 91.65           O  \nATOM   1338  CG  ASN A 166      -6.509 -12.415  -3.872  1.00 91.65           C  \nATOM   1339  ND2 ASN A 166      -5.471 -11.658  -4.138  1.00 91.65           N  \nATOM   1340  OD1 ASN A 166      -7.603 -11.899  -3.709  1.00 91.65           O  \nATOM   1341  N   TRP A 167      -3.923 -14.425  -1.519  1.00 90.40           N  \nATOM   1342  CA  TRP A 167      -2.702 -13.856  -0.981  1.00 90.40           C  \nATOM   1343  C   TRP A 167      -2.137 -12.768  -1.897  1.00 90.40           C  \nATOM   1344  CB  TRP A 167      -1.666 -14.944  -0.717  1.00 90.40           C  \nATOM   1345  O   TRP A 167      -2.183 -12.839  -3.126  1.00 90.40           O  \nATOM   1346  CG  TRP A 167      -1.952 -15.845   0.440  1.00 90.40           C  \nATOM   1347  CD1 TRP A 167      -2.144 -17.180   0.375  1.00 90.40           C  \nATOM   1348  CD2 TRP A 167      -2.079 -15.488   1.848  1.00 90.40           C  \nATOM   1349  CE2 TRP A 167      -2.278 -16.682   2.600  1.00 90.40           C  \nATOM   1350  CE3 TRP A 167      -2.045 -14.274   2.568  1.00 90.40           C  \nATOM   1351  NE1 TRP A 167      -2.307 -17.682   1.651  1.00 90.40           N  \nATOM   1352  CH2 TRP A 167      -2.369 -15.447   4.683  1.00 90.40           C  \nATOM   1353  CZ2 TRP A 167      -2.393 -16.670   3.999  1.00 90.40           C  \nATOM   1354  CZ3 TRP A 167      -2.200 -14.253   3.966  1.00 90.40           C  \nATOM   1355  N   THR A 168      -1.539 -11.759  -1.272  1.00 85.13           N  \nATOM   1356  CA  THR A 168      -0.785 -10.689  -1.934  1.00 85.13           C  \nATOM   1357  C   THR A 168       0.541 -10.491  -1.202  1.00 85.13           C  \nATOM   1358  CB  THR A 168      -1.600  -9.384  -2.016  1.00 85.13           C  \nATOM   1359  O   THR A 168       0.911 -11.282  -0.329  1.00 85.13           O  \nATOM   1360  CG2 THR A 168      -2.957  -9.564  -2.690  1.00 85.13           C  \nATOM   1361  OG1 THR A 168      -1.817  -8.853  -0.732  1.00 85.13           O  \nATOM   1362  N   LYS A 169       1.328  -9.473  -1.576  1.00 82.52           N  \nATOM   1363  CA  LYS A 169       2.564  -9.086  -0.863  1.00 82.52           C  \nATOM   1364  C   LYS A 169       3.621 -10.204  -0.744  1.00 82.52           C  \nATOM   1365  CB  LYS A 169       2.193  -8.440   0.496  1.00 82.52           C  \nATOM   1366  O   LYS A 169       4.656  -9.999  -0.122  1.00 82.52           O  \nATOM   1367  CG  LYS A 169       1.319  -7.176   0.333  1.00 82.52           C  \nATOM   1368  CD  LYS A 169       0.618  -6.732   1.630  1.00 82.52           C  \nATOM   1369  CE  LYS A 169      -0.258  -5.505   1.312  1.00 82.52           C  \nATOM   1370  NZ  LYS A 169      -1.140  -5.081   2.433  1.00 82.52           N  \nATOM   1371  N   GLY A 170       3.480 -11.314  -1.480  1.00 80.61           N  \nATOM   1372  CA  GLY A 170       4.427 -12.442  -1.535  1.00 80.61           C  \nATOM   1373  C   GLY A 170       4.076 -13.641  -0.655  1.00 80.61           C  \nATOM   1374  O   GLY A 170       4.806 -14.625  -0.697  1.00 80.61           O  \nATOM   1375  N   PHE A 171       2.982 -13.578   0.103  1.00 89.34           N  \nATOM   1376  CA  PHE A 171       2.478 -14.728   0.851  1.00 89.34           C  \nATOM   1377  C   PHE A 171       1.916 -15.785  -0.104  1.00 89.34           C  \nATOM   1378  CB  PHE A 171       1.424 -14.265   1.862  1.00 89.34           C  \nATOM   1379  O   PHE A 171       1.406 -15.445  -1.172  1.00 89.34           O  \nATOM   1380  CG  PHE A 171       2.015 -13.628   3.103  1.00 89.34           C  \nATOM   1381  CD1 PHE A 171       1.962 -14.315   4.331  1.00 89.34           C  \nATOM   1382  CD2 PHE A 171       2.633 -12.363   3.037  1.00 89.34           C  \nATOM   1383  CE1 PHE A 171       2.509 -13.736   5.488  1.00 89.34           C  \nATOM   1384  CE2 PHE A 171       3.192 -11.792   4.194  1.00 89.34           C  \nATOM   1385  CZ  PHE A 171       3.122 -12.474   5.418  1.00 89.34           C  \nATOM   1386  N   LYS A 172       2.035 -17.062   0.277  1.00 89.79           N  \nATOM   1387  CA  LYS A 172       1.477 -18.227  -0.436  1.00 89.79           C  \nATOM   1388  C   LYS A 172       1.079 -19.367   0.511  1.00 89.79           C  \nATOM   1389  CB  LYS A 172       2.446 -18.730  -1.530  1.00 89.79           C  \nATOM   1390  O   LYS A 172       1.045 -20.520   0.094  1.00 89.79           O  \nATOM   1391  CG  LYS A 172       2.618 -17.729  -2.677  1.00 89.79           C  \nATOM   1392  CD  LYS A 172       3.224 -18.370  -3.928  1.00 89.79           C  \nATOM   1393  CE  LYS A 172       3.239 -17.287  -5.008  1.00 89.79           C  \nATOM   1394  NZ  LYS A 172       3.507 -17.816  -6.365  1.00 89.79           N  \nATOM   1395  N   ALA A 173       0.804 -19.066   1.781  1.00 93.22           N  \nATOM   1396  CA  ALA A 173       0.477 -20.078   2.781  1.00 93.22           C  \nATOM   1397  C   ALA A 173      -0.770 -20.884   2.365  1.00 93.22           C  \nATOM   1398  CB  ALA A 173       0.332 -19.407   4.151  1.00 93.22           C  \nATOM   1399  O   ALA A 173      -1.904 -20.393   2.370  1.00 93.22           O  \nATOM   1400  N   SER A 174      -0.544 -22.132   1.965  1.00 95.32           N  \nATOM   1401  CA  SER A 174      -1.569 -23.014   1.409  1.00 95.32           C  \nATOM   1402  C   SER A 174      -2.645 -23.366   2.441  1.00 95.32           C  \nATOM   1403  CB  SER A 174      -0.923 -24.271   0.817  1.00 95.32           C  \nATOM   1404  O   SER A 174      -2.359 -23.548   3.624  1.00 95.32           O  \nATOM   1405  OG  SER A 174      -0.124 -24.945   1.771  1.00 95.32           O  \nATOM   1406  N   GLY A 175      -3.902 -23.451   2.000  1.00 95.88           N  \nATOM   1407  CA  GLY A 175      -5.046 -23.744   2.872  1.00 95.88           C  \nATOM   1408  C   GLY A 175      -5.612 -22.540   3.634  1.00 95.88           C  \nATOM   1409  O   GLY A 175      -6.574 -22.708   4.374  1.00 95.88           O  \nATOM   1410  N   ALA A 176      -5.055 -21.336   3.462  1.00 96.06           N  \nATOM   1411  CA  ALA A 176      -5.637 -20.123   4.037  1.00 96.06           C  \nATOM   1412  C   ALA A 176      -6.679 -19.477   3.112  1.00 96.06           C  \nATOM   1413  CB  ALA A 176      -4.514 -19.146   4.358  1.00 96.06           C  \nATOM   1414  O   ALA A 176      -7.714 -19.014   3.585  1.00 96.06           O  \nATOM   1415  N   GLU A 177      -6.421 -19.449   1.800  1.00 96.13           N  \nATOM   1416  CA  GLU A 177      -7.372 -18.920   0.815  1.00 96.13           C  \nATOM   1417  C   GLU A 177      -8.678 -19.725   0.863  1.00 96.13           C  \nATOM   1418  CB  GLU A 177      -6.768 -18.931  -0.598  1.00 96.13           C  \nATOM   1419  O   GLU A 177      -8.672 -20.947   1.036  1.00 96.13           O  \nATOM   1420  CG  GLU A 177      -5.578 -17.966  -0.731  1.00 96.13           C  \nATOM   1421  CD  GLU A 177      -4.924 -17.991  -2.123  1.00 96.13           C  \nATOM   1422  OE1 GLU A 177      -4.199 -17.017  -2.431  1.00 96.13           O  \nATOM   1423  OE2 GLU A 177      -5.069 -19.006  -2.838  1.00 96.13           O  \nATOM   1424  N   GLY A 178      -9.809 -19.027   0.786  1.00 96.55           N  \nATOM   1425  CA  GLY A 178     -11.143 -19.605   0.940  1.00 96.55           C  \nATOM   1426  C   GLY A 178     -11.528 -19.983   2.377  1.00 96.55           C  \nATOM   1427  O   GLY A 178     -12.643 -20.458   2.584  1.00 96.55           O  \nATOM   1428  N   ASN A 179     -10.665 -19.759   3.376  1.00 97.11           N  \nATOM   1429  CA  ASN A 179     -10.917 -20.130   4.771  1.00 97.11           C  \nATOM   1430  C   ASN A 179     -11.054 -18.912   5.696  1.00 97.11           C  \nATOM   1431  CB  ASN A 179      -9.843 -21.124   5.245  1.00 97.11           C  \nATOM   1432  O   ASN A 179     -10.570 -17.816   5.409  1.00 97.11           O  \nATOM   1433  CG  ASN A 179     -10.032 -22.483   4.602  1.00 97.11           C  \nATOM   1434  ND2 ASN A 179      -9.471 -22.721   3.441  1.00 97.11           N  \nATOM   1435  OD1 ASN A 179     -10.743 -23.328   5.120  1.00 97.11           O  \nATOM   1436  N   ASN A 180     -11.733 -19.119   6.831  1.00 96.72           N  \nATOM   1437  CA  ASN A 180     -11.929 -18.089   7.851  1.00 96.72           C  \nATOM   1438  C   ASN A 180     -10.626 -17.821   8.616  1.00 96.72           C  \nATOM   1439  CB  ASN A 180     -13.073 -18.502   8.797  1.00 96.72           C  \nATOM   1440  O   ASN A 180     -10.203 -18.648   9.425  1.00 96.72           O  \nATOM   1441  CG  ASN A 180     -13.312 -17.490   9.911  1.00 96.72           C  \nATOM   1442  ND2 ASN A 180     -14.085 -17.843  10.910  1.00 96.72           N  \nATOM   1443  OD1 ASN A 180     -12.806 -16.381   9.929  1.00 96.72           O  \nATOM   1444  N   VAL A 181     -10.046 -16.637   8.421  1.00 96.62           N  \nATOM   1445  CA  VAL A 181      -8.781 -16.204   9.037  1.00 96.62           C  \nATOM   1446  C   VAL A 181      -8.849 -16.231  10.566  1.00 96.62           C  \nATOM   1447  CB  VAL A 181      -8.435 -14.790   8.532  1.00 96.62           C  \nATOM   1448  O   VAL A 181      -7.937 -16.733  11.224  1.00 96.62           O  \nATOM   1449  CG1 VAL A 181      -7.224 -14.184   9.245  1.00 96.62           C  \nATOM   1450  CG2 VAL A 181      -8.149 -14.805   7.025  1.00 96.62           C  \nATOM   1451  N   VAL A 182      -9.956 -15.759  11.147  1.00 95.63           N  \nATOM   1452  CA  VAL A 182     -10.154 -15.778  12.604  1.00 95.63           C  \nATOM   1453  C   VAL A 182     -10.295 -17.210  13.120  1.00 95.63           C  \nATOM   1454  CB  VAL A 182     -11.363 -14.909  13.003  1.00 95.63           C  \nATOM   1455  O   VAL A 182      -9.796 -17.527  14.198  1.00 95.63           O  \nATOM   1456  CG1 VAL A 182     -11.667 -15.016  14.501  1.00 95.63           C  \nATOM   1457  CG2 VAL A 182     -11.067 -13.446  12.651  1.00 95.63           C  \nATOM   1458  N   GLY A 183     -10.918 -18.095  12.339  1.00 95.97           N  \nATOM   1459  CA  GLY A 183     -10.987 -19.527  12.640  1.00 95.97           C  \nATOM   1460  C   GLY A 183      -9.600 -20.166  12.698  1.00 95.97           C  \nATOM   1461  O   GLY A 183      -9.263 -20.795  13.696  1.00 95.97           O  \nATOM   1462  N   LEU A 184      -8.766 -19.914  11.684  1.00 97.06           N  \nATOM   1463  CA  LEU A 184      -7.391 -20.421  11.619  1.00 97.06           C  \nATOM   1464  C   LEU A 184      -6.544 -19.950  12.812  1.00 97.06           C  \nATOM   1465  CB  LEU A 184      -6.747 -19.974  10.294  1.00 97.06           C  \nATOM   1466  O   LEU A 184      -5.822 -20.749  13.414  1.00 97.06           O  \nATOM   1467  CG  LEU A 184      -7.382 -20.576   9.027  1.00 97.06           C  \nATOM   1468  CD1 LEU A 184      -6.853 -19.870   7.780  1.00 97.06           C  \nATOM   1469  CD2 LEU A 184      -7.074 -22.068   8.895  1.00 97.06           C  \nATOM   1470  N   LEU A 185      -6.673 -18.676  13.198  1.00 96.68           N  \nATOM   1471  CA  LEU A 185      -6.004 -18.130  14.379  1.00 96.68           C  \nATOM   1472  C   LEU A 185      -6.511 -18.776  15.681  1.00 96.68           C  \nATOM   1473  CB  LEU A 185      -6.186 -16.601  14.387  1.00 96.68           C  \nATOM   1474  O   LEU A 185      -5.706 -19.158  16.532  1.00 96.68           O  \nATOM   1475  CG  LEU A 185      -5.550 -15.904  15.604  1.00 96.68           C  \nATOM   1476  CD1 LEU A 185      -4.038 -16.126  15.682  1.00 96.68           C  \nATOM   1477  CD2 LEU A 185      -5.810 -14.401  15.539  1.00 96.68           C  \nATOM   1478  N   ARG A 186      -7.834 -18.926  15.841  1.00 95.31           N  \nATOM   1479  CA  ARG A 186      -8.446 -19.579  17.014  1.00 95.31           C  \nATOM   1480  C   ARG A 186      -7.979 -21.032  17.145  1.00 95.31           C  \nATOM   1481  CB  ARG A 186      -9.986 -19.486  16.939  1.00 95.31           C  \nATOM   1482  O   ARG A 186      -7.646 -21.463  18.250  1.00 95.31           O  \nATOM   1483  CG  ARG A 186     -10.549 -18.097  17.314  1.00 95.31           C  \nATOM   1484  CD  ARG A 186     -12.075 -18.015  17.087  1.00 95.31           C  \nATOM   1485  NE  ARG A 186     -12.661 -16.704  17.484  1.00 95.31           N  \nATOM   1486  NH1 ARG A 186     -14.656 -16.815  16.327  1.00 95.31           N  \nATOM   1487  NH2 ARG A 186     -14.198 -14.969  17.420  1.00 95.31           N  \nATOM   1488  CZ  ARG A 186     -13.820 -16.174  17.091  1.00 95.31           C  \nATOM   1489  N   ASP A 187      -7.891 -21.761  16.036  1.00 96.37           N  \nATOM   1490  CA  ASP A 187      -7.407 -23.141  16.023  1.00 96.37           C  \nATOM   1491  C   ASP A 187      -5.929 -23.235  16.425  1.00 96.37           C  \nATOM   1492  CB  ASP A 187      -7.643 -23.775  14.645  1.00 96.37           C  \nATOM   1493  O   ASP A 187      -5.574 -24.099  17.227  1.00 96.37           O  \nATOM   1494  CG  ASP A 187      -9.111 -24.089  14.341  1.00 96.37           C  \nATOM   1495  OD1 ASP A 187      -9.906 -24.215  15.305  1.00 96.37           O  \nATOM   1496  OD2 ASP A 187      -9.402 -24.303  13.145  1.00 96.37           O  \nATOM   1497  N   ALA A 188      -5.078 -22.318  15.951  1.00 97.04           N  \nATOM   1498  CA  ALA A 188      -3.666 -22.259  16.341  1.00 97.04           C  \nATOM   1499  C   ALA A 188      -3.479 -21.981  17.839  1.00 97.04           C  \nATOM   1500  CB  ALA A 188      -2.968 -21.200  15.486  1.00 97.04           C  \nATOM   1501  O   ALA A 188      -2.727 -22.679  18.523  1.00 97.04           O  \nATOM   1502  N   ILE A 189      -4.223 -21.014  18.383  1.00 95.02           N  \nATOM   1503  CA  ILE A 189      -4.211 -20.707  19.822  1.00 95.02           C  \nATOM   1504  C   ILE A 189      -4.666 -21.926  20.634  1.00 95.02           C  \nATOM   1505  CB  ILE A 189      -5.075 -19.457  20.103  1.00 95.02           C  \nATOM   1506  O   ILE A 189      -4.026 -22.291  21.621  1.00 95.02           O  \nATOM   1507  CG1 ILE A 189      -4.421 -18.212  19.458  1.00 95.02           C  \nATOM   1508  CG2 ILE A 189      -5.259 -19.243  21.619  1.00 95.02           C  \nATOM   1509  CD1 ILE A 189      -5.347 -16.992  19.402  1.00 95.02           C  \nATOM   1510  N   LYS A 190      -5.730 -22.608  20.193  1.00 95.16           N  \nATOM   1511  CA  LYS A 190      -6.240 -23.812  20.856  1.00 95.16           C  \nATOM   1512  C   LYS A 190      -5.250 -24.979  20.806  1.00 95.16           C  \nATOM   1513  CB  LYS A 190      -7.585 -24.184  20.227  1.00 95.16           C  \nATOM   1514  O   LYS A 190      -5.120 -25.682  21.806  1.00 95.16           O  \nATOM   1515  CG  LYS A 190      -8.245 -25.364  20.950  1.00 95.16           C  \nATOM   1516  CD  LYS A 190      -9.587 -25.672  20.290  1.00 95.16           C  \nATOM   1517  CE  LYS A 190     -10.233 -26.884  20.961  1.00 95.16           C  \nATOM   1518  NZ  LYS A 190     -11.504 -27.219  20.278  1.00 95.16           N  \nATOM   1519  N   ARG A 191      -4.565 -25.198  19.675  1.00 96.74           N  \nATOM   1520  CA  ARG A 191      -3.508 -26.219  19.544  1.00 96.74           C  \nATOM   1521  C   ARG A 191      -2.360 -25.965  20.517  1.00 96.74           C  \nATOM   1522  CB  ARG A 191      -2.950 -26.258  18.109  1.00 96.74           C  \nATOM   1523  O   ARG A 191      -1.844 -26.920  21.091  1.00 96.74           O  \nATOM   1524  CG  ARG A 191      -3.834 -27.023  17.113  1.00 96.74           C  \nATOM   1525  CD  ARG A 191      -3.109 -27.213  15.768  1.00 96.74           C  \nATOM   1526  NE  ARG A 191      -2.840 -25.940  15.073  1.00 96.74           N  \nATOM   1527  NH1 ARG A 191      -4.845 -25.720  13.971  1.00 96.74           N  \nATOM   1528  NH2 ARG A 191      -3.267 -24.162  13.751  1.00 96.74           N  \nATOM   1529  CZ  ARG A 191      -3.654 -25.285  14.270  1.00 96.74           C  \nATOM   1530  N   ARG A 192      -1.984 -24.698  20.718  1.00 94.64           N  \nATOM   1531  CA  ARG A 192      -0.926 -24.313  21.659  1.00 94.64           C  \nATOM   1532  C   ARG A 192      -1.342 -24.500  23.122  1.00 94.64           C  \nATOM   1533  CB  ARG A 192      -0.491 -22.877  21.353  1.00 94.64           C  \nATOM   1534  O   ARG A 192      -0.592 -25.093  23.892  1.00 94.64           O  \nATOM   1535  CG  ARG A 192       0.772 -22.530  22.147  1.00 94.64           C  \nATOM   1536  CD  ARG A 192       1.203 -21.090  21.864  1.00 94.64           C  \nATOM   1537  NE  ARG A 192       1.872 -21.004  20.555  1.00 94.64           N  \nATOM   1538  NH1 ARG A 192       3.996 -21.481  21.269  1.00 94.64           N  \nATOM   1539  NH2 ARG A 192       3.568 -21.408  19.083  1.00 94.64           N  \nATOM   1540  CZ  ARG A 192       3.135 -21.299  20.306  1.00 94.64           C  \nATOM   1541  N   GLY A 193      -2.530 -24.022  23.496  1.00 93.23           N  \nATOM   1542  CA  GLY A 193      -3.185 -24.342  24.771  1.00 93.23           C  \nATOM   1543  C   GLY A 193      -2.636 -23.666  26.037  1.00 93.23           C  \nATOM   1544  O   GLY A 193      -3.010 -24.079  27.132  1.00 93.23           O  \nATOM   1545  N   ASP A 194      -1.772 -22.651  25.932  1.00 93.22           N  \nATOM   1546  CA  ASP A 194      -1.150 -21.963  27.080  1.00 93.22           C  \nATOM   1547  C   ASP A 194      -1.712 -20.557  27.374  1.00 93.22           C  \nATOM   1548  CB  ASP A 194       0.378 -21.949  26.907  1.00 93.22           C  \nATOM   1549  O   ASP A 194      -1.338 -19.945  28.377  1.00 93.22           O  \nATOM   1550  CG  ASP A 194       0.866 -21.039  25.777  1.00 93.22           C  \nATOM   1551  OD1 ASP A 194       0.147 -20.881  24.771  1.00 93.22           O  \nATOM   1552  OD2 ASP A 194       1.983 -20.483  25.903  1.00 93.22           O  \nATOM   1553  N   PHE A 195      -2.621 -20.047  26.539  1.00 93.21           N  \nATOM   1554  CA  PHE A 195      -3.395 -18.826  26.782  1.00 93.21           C  \nATOM   1555  C   PHE A 195      -4.744 -18.872  26.046  1.00 93.21           C  \nATOM   1556  CB  PHE A 195      -2.576 -17.583  26.383  1.00 93.21           C  \nATOM   1557  O   PHE A 195      -4.942 -19.659  25.120  1.00 93.21           O  \nATOM   1558  CG  PHE A 195      -2.262 -17.477  24.902  1.00 93.21           C  \nATOM   1559  CD1 PHE A 195      -1.097 -18.062  24.383  1.00 93.21           C  \nATOM   1560  CD2 PHE A 195      -3.144 -16.812  24.034  1.00 93.21           C  \nATOM   1561  CE1 PHE A 195      -0.833 -18.013  23.005  1.00 93.21           C  \nATOM   1562  CE2 PHE A 195      -2.870 -16.760  22.655  1.00 93.21           C  \nATOM   1563  CZ  PHE A 195      -1.711 -17.355  22.139  1.00 93.21           C  \nATOM   1564  N   GLU A 196      -5.671 -18.001  26.443  1.00 89.91           N  \nATOM   1565  CA  GLU A 196      -6.952 -17.799  25.759  1.00 89.91           C  \nATOM   1566  C   GLU A 196      -7.050 -16.384  25.189  1.00 89.91           C  \nATOM   1567  CB  GLU A 196      -8.142 -18.035  26.698  1.00 89.91           C  \nATOM   1568  O   GLU A 196      -6.551 -15.426  25.780  1.00 89.91           O  \nATOM   1569  CG  GLU A 196      -8.361 -19.506  27.077  1.00 89.91           C  \nATOM   1570  CD  GLU A 196      -9.680 -19.717  27.846  1.00 89.91           C  \nATOM   1571  OE1 GLU A 196      -9.804 -20.781  28.488  1.00 89.91           O  \nATOM   1572  OE2 GLU A 196     -10.590 -18.841  27.763  1.00 89.91           O  \nATOM   1573  N   MET A 197      -7.752 -16.243  24.065  1.00 86.16           N  \nATOM   1574  CA  MET A 197      -8.072 -14.947  23.468  1.00 86.16           C  \nATOM   1575  C   MET A 197      -9.505 -14.904  22.982  1.00 86.16           C  \nATOM   1576  CB  MET A 197      -7.174 -14.648  22.272  1.00 86.16           C  \nATOM   1577  O   MET A 197     -10.088 -15.936  22.648  1.00 86.16           O  \nATOM   1578  CG  MET A 197      -5.728 -14.555  22.701  1.00 86.16           C  \nATOM   1579  SD  MET A 197      -4.702 -13.979  21.349  1.00 86.16           S  \nATOM   1580  CE  MET A 197      -3.826 -12.740  22.285  1.00 86.16           C  \nATOM   1581  N   ASP A 198     -10.027 -13.688  22.891  1.00 88.89           N  \nATOM   1582  CA  ASP A 198     -11.317 -13.413  22.286  1.00 88.89           C  \nATOM   1583  C   ASP A 198     -11.131 -12.440  21.119  1.00 88.89           C  \nATOM   1584  CB  ASP A 198     -12.259 -12.889  23.376  1.00 88.89           C  \nATOM   1585  O   ASP A 198     -10.946 -11.243  21.328  1.00 88.89           O  \nATOM   1586  CG  ASP A 198     -13.711 -12.854  22.909  1.00 88.89           C  \nATOM   1587  OD1 ASP A 198     -14.000 -13.501  21.877  1.00 88.89           O  \nATOM   1588  OD2 ASP A 198     -14.518 -12.268  23.660  1.00 88.89           O  \nATOM   1589  N   VAL A 199     -11.084 -12.962  19.888  1.00 93.03           N  \nATOM   1590  CA  VAL A 199     -11.050 -12.122  18.679  1.00 93.03           C  \nATOM   1591  C   VAL A 199     -12.428 -11.509  18.510  1.00 93.03           C  \nATOM   1592  CB  VAL A 199     -10.644 -12.886  17.404  1.00 93.03           C  \nATOM   1593  O   VAL A 199     -13.359 -12.229  18.159  1.00 93.03           O  \nATOM   1594  CG1 VAL A 199     -10.545 -11.921  16.211  1.00 93.03           C  \nATOM   1595  CG2 VAL A 199      -9.285 -13.578  17.545  1.00 93.03           C  \nATOM   1596  N   VAL A 200     -12.529 -10.206  18.768  1.00 93.35           N  \nATOM   1597  CA  VAL A 200     -13.789  -9.447  18.718  1.00 93.35           C  \nATOM   1598  C   VAL A 200     -13.921  -8.611  17.449  1.00 93.35           C  \nATOM   1599  CB  VAL A 200     -13.957  -8.549  19.958  1.00 93.35           C  \nATOM   1600  O   VAL A 200     -15.015  -8.170  17.113  1.00 93.35           O  \nATOM   1601  CG1 VAL A 200     -14.034  -9.375  21.245  1.00 93.35           C  \nATOM   1602  CG2 VAL A 200     -12.830  -7.518  20.105  1.00 93.35           C  \nATOM   1603  N   ALA A 201     -12.808  -8.374  16.755  1.00 93.65           N  \nATOM   1604  CA  ALA A 201     -12.792  -7.673  15.484  1.00 93.65           C  \nATOM   1605  C   ALA A 201     -11.595  -8.108  14.637  1.00 93.65           C  \nATOM   1606  CB  ALA A 201     -12.760  -6.160  15.738  1.00 93.65           C  \nATOM   1607  O   ALA A 201     -10.490  -8.315  15.144  1.00 93.65           O  \nATOM   1608  N   MET A 202     -11.809  -8.184  13.330  1.00 94.70           N  \nATOM   1609  CA  MET A 202     -10.775  -8.287  12.317  1.00 94.70           C  \nATOM   1610  C   MET A 202     -10.983  -7.168  11.300  1.00 94.70           C  \nATOM   1611  CB  MET A 202     -10.809  -9.673  11.672  1.00 94.70           C  \nATOM   1612  O   MET A 202     -12.105  -6.920  10.871  1.00 94.70           O  \nATOM   1613  CG  MET A 202      -9.650  -9.857  10.685  1.00 94.70           C  \nATOM   1614  SD  MET A 202      -9.585 -11.479   9.893  1.00 94.70           S  \nATOM   1615  CE  MET A 202     -11.117 -11.403   8.947  1.00 94.70           C  \nATOM   1616  N   VAL A 203      -9.911  -6.485  10.915  1.00 95.14           N  \nATOM   1617  CA  VAL A 203      -9.963  -5.352   9.985  1.00 95.14           C  \nATOM   1618  C   VAL A 203      -8.778  -5.373   9.029  1.00 95.14           C  \nATOM   1619  CB  VAL A 203     -10.035  -4.004  10.730  1.00 95.14           C  \nATOM   1620  O   VAL A 203      -7.734  -5.947   9.327  1.00 95.14           O  \nATOM   1621  CG1 VAL A 203     -11.371  -3.836  11.458  1.00 95.14           C  \nATOM   1622  CG2 VAL A 203      -8.895  -3.786  11.734  1.00 95.14           C  \nATOM   1623  N   ASN A 204      -8.923  -4.721   7.878  1.00 94.92           N  \nATOM   1624  CA  ASN A 204      -7.790  -4.434   7.001  1.00 94.92           C  \nATOM   1625  C   ASN A 204      -6.929  -3.292   7.580  1.00 94.92           C  \nATOM   1626  CB  ASN A 204      -8.330  -4.155   5.593  1.00 94.92           C  \nATOM   1627  O   ASN A 204      -7.413  -2.474   8.367  1.00 94.92           O  \nATOM   1628  CG  ASN A 204      -7.226  -3.996   4.568  1.00 94.92           C  \nATOM   1629  ND2 ASN A 204      -6.674  -5.081   4.078  1.00 94.92           N  \nATOM   1630  OD1 ASN A 204      -6.852  -2.890   4.216  1.00 94.92           O  \nATOM   1631  N   ASP A 205      -5.657  -3.216   7.183  1.00 94.58           N  \nATOM   1632  CA  ASP A 205      -4.729  -2.179   7.651  1.00 94.58           C  \nATOM   1633  C   ASP A 205      -5.177  -0.768   7.279  1.00 94.58           C  \nATOM   1634  CB  ASP A 205      -3.285  -2.461   7.191  1.00 94.58           C  \nATOM   1635  O   ASP A 205      -5.083   0.131   8.110  1.00 94.58           O  \nATOM   1636  CG  ASP A 205      -3.069  -2.737   5.691  1.00 94.58           C  \nATOM   1637  OD1 ASP A 205      -4.038  -2.723   4.909  1.00 94.58           O  \nATOM   1638  OD2 ASP A 205      -1.913  -3.055   5.316  1.00 94.58           O  \nATOM   1639  N   THR A 206      -5.756  -0.586   6.093  1.00 95.88           N  \nATOM   1640  CA  THR A 206      -6.367   0.690   5.688  1.00 95.88           C  \nATOM   1641  C   THR A 206      -7.443   1.154   6.674  1.00 95.88           C  \nATOM   1642  CB  THR A 206      -6.976   0.588   4.285  1.00 95.88           C  \nATOM   1643  O   THR A 206      -7.415   2.302   7.123  1.00 95.88           O  \nATOM   1644  CG2 THR A 206      -5.928   0.342   3.206  1.00 95.88           C  \nATOM   1645  OG1 THR A 206      -7.911  -0.464   4.208  1.00 95.88           O  \nATOM   1646  N   VAL A 207      -8.342   0.251   7.080  1.00 95.88           N  \nATOM   1647  CA  VAL A 207      -9.445   0.525   8.018  1.00 95.88           C  \nATOM   1648  C   VAL A 207      -8.897   0.887   9.388  1.00 95.88           C  \nATOM   1649  CB  VAL A 207     -10.387  -0.686   8.138  1.00 95.88           C  \nATOM   1650  O   VAL A 207      -9.314   1.877   9.985  1.00 95.88           O  \nATOM   1651  CG1 VAL A 207     -11.580  -0.404   9.061  1.00 95.88           C  \nATOM   1652  CG2 VAL A 207     -10.931  -1.129   6.777  1.00 95.88           C  \nATOM   1653  N   ALA A 208      -7.921   0.125   9.878  1.00 95.26           N  \nATOM   1654  CA  ALA A 208      -7.274   0.431  11.143  1.00 95.26           C  \nATOM   1655  C   ALA A 208      -6.569   1.802  11.105  1.00 95.26           C  \nATOM   1656  CB  ALA A 208      -6.328  -0.717  11.475  1.00 95.26           C  \nATOM   1657  O   ALA A 208      -6.763   2.614  12.010  1.00 95.26           O  \nATOM   1658  N   THR A 209      -5.835   2.114  10.036  1.00 95.63           N  \nATOM   1659  CA  THR A 209      -5.224   3.435   9.836  1.00 95.63           C  \nATOM   1660  C   THR A 209      -6.267   4.555   9.845  1.00 95.63           C  \nATOM   1661  CB  THR A 209      -4.410   3.442   8.533  1.00 95.63           C  \nATOM   1662  O   THR A 209      -6.071   5.545  10.551  1.00 95.63           O  \nATOM   1663  CG2 THR A 209      -3.883   4.817   8.133  1.00 95.63           C  \nATOM   1664  OG1 THR A 209      -3.279   2.627   8.714  1.00 95.63           O  \nATOM   1665  N   MET A 210      -7.393   4.388   9.141  1.00 96.29           N  \nATOM   1666  CA  MET A 210      -8.489   5.364   9.138  1.00 96.29           C  \nATOM   1667  C   MET A 210      -9.025   5.604  10.549  1.00 96.29           C  \nATOM   1668  CB  MET A 210      -9.639   4.874   8.248  1.00 96.29           C  \nATOM   1669  O   MET A 210      -9.120   6.746  10.981  1.00 96.29           O  \nATOM   1670  CG  MET A 210     -10.691   5.962   8.009  1.00 96.29           C  \nATOM   1671  SD  MET A 210     -12.088   5.395   7.004  1.00 96.29           S  \nATOM   1672  CE  MET A 210     -12.898   4.309   8.207  1.00 96.29           C  \nATOM   1673  N   ILE A 211      -9.336   4.535  11.287  1.00 93.69           N  \nATOM   1674  CA  ILE A 211      -9.911   4.624  12.634  1.00 93.69           C  \nATOM   1675  C   ILE A 211      -8.920   5.234  13.630  1.00 93.69           C  \nATOM   1676  CB  ILE A 211     -10.402   3.229  13.081  1.00 93.69           C  \nATOM   1677  O   ILE A 211      -9.310   6.035  14.480  1.00 93.69           O  \nATOM   1678  CG1 ILE A 211     -11.576   2.724  12.207  1.00 93.69           C  \nATOM   1679  CG2 ILE A 211     -10.792   3.227  14.569  1.00 93.69           C  \nATOM   1680  CD1 ILE A 211     -12.879   3.523  12.312  1.00 93.69           C  \nATOM   1681  N   SER A 212      -7.635   4.899  13.513  1.00 91.80           N  \nATOM   1682  CA  SER A 212      -6.592   5.497  14.346  1.00 91.80           C  \nATOM   1683  C   SER A 212      -6.480   7.005  14.122  1.00 91.80           C  \nATOM   1684  CB  SER A 212      -5.247   4.834  14.064  1.00 91.80           C  \nATOM   1685  O   SER A 212      -6.331   7.746  15.088  1.00 91.80           O  \nATOM   1686  OG  SER A 212      -4.287   5.309  14.989  1.00 91.80           O  \nATOM   1687  N   CYS A 213      -6.554   7.462  12.871  1.00 92.71           N  \nATOM   1688  CA  CYS A 213      -6.515   8.886  12.544  1.00 92.71           C  \nATOM   1689  C   CYS A 213      -7.844   9.593  12.852  1.00 92.71           C  \nATOM   1690  CB  CYS A 213      -6.111   9.039  11.075  1.00 92.71           C  \nATOM   1691  O   CYS A 213      -7.823  10.747  13.265  1.00 92.71           O  \nATOM   1692  SG  CYS A 213      -4.368   8.571  10.858  1.00 92.71           S  \nATOM   1693  N   TYR A 214      -8.984   8.903  12.738  1.00 91.52           N  \nATOM   1694  CA  TYR A 214     -10.296   9.438  13.117  1.00 91.52           C  \nATOM   1695  C   TYR A 214     -10.348   9.866  14.579  1.00 91.52           C  \nATOM   1696  CB  TYR A 214     -11.397   8.416  12.826  1.00 91.52           C  \nATOM   1697  O   TYR A 214     -10.935  10.888  14.919  1.00 91.52           O  \nATOM   1698  CG  TYR A 214     -12.776   8.993  13.070  1.00 91.52           C  \nATOM   1699  CD1 TYR A 214     -13.323   9.026  14.368  1.00 91.52           C  \nATOM   1700  CD2 TYR A 214     -13.480   9.575  12.003  1.00 91.52           C  \nATOM   1701  CE1 TYR A 214     -14.580   9.618  14.589  1.00 91.52           C  \nATOM   1702  CE2 TYR A 214     -14.741  10.154  12.211  1.00 91.52           C  \nATOM   1703  OH  TYR A 214     -16.521  10.711  13.698  1.00 91.52           O  \nATOM   1704  CZ  TYR A 214     -15.288  10.182  13.507  1.00 91.52           C  \nATOM   1705  N   TYR A 215      -9.690   9.098  15.445  1.00 84.36           N  \nATOM   1706  CA  TYR A 215      -9.577   9.437  16.856  1.00 84.36           C  \nATOM   1707  C   TYR A 215      -8.896  10.807  17.087  1.00 84.36           C  \nATOM   1708  CB  TYR A 215      -8.839   8.276  17.534  1.00 84.36           C  \nATOM   1709  O   TYR A 215      -9.186  11.479  18.074  1.00 84.36           O  \nATOM   1710  CG  TYR A 215      -8.569   8.523  18.993  1.00 84.36           C  \nATOM   1711  CD1 TYR A 215      -7.447   9.291  19.338  1.00 84.36           C  \nATOM   1712  CD2 TYR A 215      -9.486   8.111  19.977  1.00 84.36           C  \nATOM   1713  CE1 TYR A 215      -7.229   9.670  20.667  1.00 84.36           C  \nATOM   1714  CE2 TYR A 215      -9.281   8.499  21.314  1.00 84.36           C  \nATOM   1715  OH  TYR A 215      -7.958   9.759  22.895  1.00 84.36           O  \nATOM   1716  CZ  TYR A 215      -8.160   9.296  21.645  1.00 84.36           C  \nATOM   1717  N   GLU A 216      -7.998  11.232  16.195  1.00 84.88           N  \nATOM   1718  CA  GLU A 216      -7.307  12.530  16.270  1.00 84.88           C  \nATOM   1719  C   GLU A 216      -8.062  13.633  15.520  1.00 84.88           C  \nATOM   1720  CB  GLU A 216      -5.880  12.380  15.718  1.00 84.88           C  \nATOM   1721  O   GLU A 216      -8.081  14.783  15.957  1.00 84.88           O  \nATOM   1722  CG  GLU A 216      -5.049  11.438  16.602  1.00 84.88           C  \nATOM   1723  CD  GLU A 216      -3.659  11.110  16.050  1.00 84.88           C  \nATOM   1724  OE1 GLU A 216      -3.081  10.145  16.615  1.00 84.88           O  \nATOM   1725  OE2 GLU A 216      -3.194  11.785  15.106  1.00 84.88           O  \nATOM   1726  N   ASP A 217      -8.716  13.280  14.415  1.00 90.56           N  \nATOM   1727  CA  ASP A 217      -9.524  14.179  13.602  1.00 90.56           C  \nATOM   1728  C   ASP A 217     -10.779  13.465  13.089  1.00 90.56           C  \nATOM   1729  CB  ASP A 217      -8.671  14.713  12.445  1.00 90.56           C  \nATOM   1730  O   ASP A 217     -10.717  12.606  12.209  1.00 90.56           O  \nATOM   1731  CG  ASP A 217      -9.414  15.716  11.561  1.00 90.56           C  \nATOM   1732  OD1 ASP A 217     -10.615  15.981  11.804  1.00 90.56           O  \nATOM   1733  OD2 ASP A 217      -8.775  16.203  10.603  1.00 90.56           O  \nATOM   1734  N   HIS A 218     -11.944  13.891  13.580  1.00 90.50           N  \nATOM   1735  CA  HIS A 218     -13.245  13.313  13.236  1.00 90.50           C  \nATOM   1736  C   HIS A 218     -13.663  13.566  11.773  1.00 90.50           C  \nATOM   1737  CB  HIS A 218     -14.308  13.845  14.211  1.00 90.50           C  \nATOM   1738  O   HIS A 218     -14.726  13.113  11.352  1.00 90.50           O  \nATOM   1739  CG  HIS A 218     -14.121  13.401  15.641  1.00 90.50           C  \nATOM   1740  CD2 HIS A 218     -14.893  12.492  16.313  1.00 90.50           C  \nATOM   1741  ND1 HIS A 218     -13.159  13.839  16.527  1.00 90.50           N  \nATOM   1742  CE1 HIS A 218     -13.342  13.196  17.691  1.00 90.50           C  \nATOM   1743  NE2 HIS A 218     -14.401  12.380  17.615  1.00 90.50           N  \nATOM   1744  N   GLN A 219     -12.867  14.302  10.991  1.00 93.33           N  \nATOM   1745  CA  GLN A 219     -13.011  14.418   9.535  1.00 93.33           C  \nATOM   1746  C   GLN A 219     -12.255  13.313   8.771  1.00 93.33           C  \nATOM   1747  CB  GLN A 219     -12.543  15.812   9.082  1.00 93.33           C  \nATOM   1748  O   GLN A 219     -12.288  13.290   7.539  1.00 93.33           O  \nATOM   1749  CG  GLN A 219     -13.286  16.979   9.748  1.00 93.33           C  \nATOM   1750  CD  GLN A 219     -14.760  17.025   9.367  1.00 93.33           C  \nATOM   1751  NE2 GLN A 219     -15.656  16.532  10.192  1.00 93.33           N  \nATOM   1752  OE1 GLN A 219     -15.139  17.517   8.321  1.00 93.33           O  \nATOM   1753  N   CYS A 220     -11.541  12.413   9.462  1.00 95.56           N  \nATOM   1754  CA  CYS A 220     -10.745  11.366   8.825  1.00 95.56           C  \nATOM   1755  C   CYS A 220     -11.609  10.201   8.335  1.00 95.56           C  \nATOM   1756  CB  CYS A 220      -9.612  10.912   9.743  1.00 95.56           C  \nATOM   1757  O   CYS A 220     -11.838   9.225   9.044  1.00 95.56           O  \nATOM   1758  SG  CYS A 220      -8.577   9.726   8.840  1.00 95.56           S  \nATOM   1759  N   GLU A 221     -12.046  10.283   7.085  1.00 96.16           N  \nATOM   1760  CA  GLU A 221     -12.952   9.303   6.478  1.00 96.16           C  \nATOM   1761  C   GLU A 221     -12.312   8.494   5.347  1.00 96.16           C  \nATOM   1762  CB  GLU A 221     -14.236  10.005   6.041  1.00 96.16           C  \nATOM   1763  O   GLU A 221     -13.010   7.766   4.641  1.00 96.16           O  \nATOM   1764  CG  GLU A 221     -15.003  10.589   7.239  1.00 96.16           C  \nATOM   1765  CD  GLU A 221     -16.401  11.044   6.825  1.00 96.16           C  \nATOM   1766  OE1 GLU A 221     -17.332  11.017   7.664  1.00 96.16           O  \nATOM   1767  OE2 GLU A 221     -16.582  11.339   5.625  1.00 96.16           O  \nATOM   1768  N   VAL A 222     -10.988   8.598   5.191  1.00 98.08           N  \nATOM   1769  CA  VAL A 222     -10.179   7.778   4.282  1.00 98.08           C  \nATOM   1770  C   VAL A 222      -8.957   7.254   5.028  1.00 98.08           C  \nATOM   1771  CB  VAL A 222      -9.741   8.570   3.036  1.00 98.08           C  \nATOM   1772  O   VAL A 222      -8.245   8.020   5.680  1.00 98.08           O  \nATOM   1773  CG1 VAL A 222      -8.985   7.695   2.027  1.00 98.08           C  \nATOM   1774  CG2 VAL A 222     -10.920   9.198   2.289  1.00 98.08           C  \nATOM   1775  N   GLY A 223      -8.691   5.956   4.904  1.00 97.90           N  \nATOM   1776  CA  GLY A 223      -7.450   5.327   5.349  1.00 97.90           C  \nATOM   1777  C   GLY A 223      -6.646   4.835   4.160  1.00 97.90           C  \nATOM   1778  O   GLY A 223      -7.185   4.162   3.286  1.00 97.90           O  \nATOM   1779  N   MET A 224      -5.355   5.148   4.120  1.00 97.88           N  \nATOM   1780  CA  MET A 224      -4.455   4.743   3.047  1.00 97.88           C  \nATOM   1781  C   MET A 224      -3.206   4.066   3.583  1.00 97.88           C  \nATOM   1782  CB  MET A 224      -4.024   5.946   2.210  1.00 97.88           C  \nATOM   1783  O   MET A 224      -2.588   4.532   4.539  1.00 97.88           O  \nATOM   1784  CG  MET A 224      -5.168   6.554   1.405  1.00 97.88           C  \nATOM   1785  SD  MET A 224      -4.592   7.772   0.198  1.00 97.88           S  \nATOM   1786  CE  MET A 224      -3.627   6.723  -0.910  1.00 97.88           C  \nATOM   1787  N   ILE A 225      -2.779   3.027   2.874  1.00 96.64           N  \nATOM   1788  CA  ILE A 225      -1.469   2.412   3.048  1.00 96.64           C  \nATOM   1789  C   ILE A 225      -0.663   2.655   1.778  1.00 96.64           C  \nATOM   1790  CB  ILE A 225      -1.604   0.915   3.384  1.00 96.64           C  \nATOM   1791  O   ILE A 225      -1.080   2.260   0.692  1.00 96.64           O  \nATOM   1792  CG1 ILE A 225      -2.465   0.671   4.641  1.00 96.64           C  \nATOM   1793  CG2 ILE A 225      -0.216   0.266   3.543  1.00 96.64           C  \nATOM   1794  CD1 ILE A 225      -1.953   1.277   5.950  1.00 96.64           C  \nATOM   1795  N   VAL A 226       0.503   3.285   1.910  1.00 97.26           N  \nATOM   1796  CA  VAL A 226       1.485   3.474   0.834  1.00 97.26           C  \nATOM   1797  C   VAL A 226       2.853   3.040   1.363  1.00 97.26           C  \nATOM   1798  CB  VAL A 226       1.483   4.918   0.303  1.00 97.26           C  \nATOM   1799  O   VAL A 226       3.667   3.832   1.845  1.00 97.26           O  \nATOM   1800  CG1 VAL A 226       2.283   4.996  -1.001  1.00 97.26           C  \nATOM   1801  CG2 VAL A 226       0.083   5.479   0.020  1.00 97.26           C  \nATOM   1802  N   GLY A 227       3.075   1.728   1.356  1.00 94.28           N  \nATOM   1803  CA  GLY A 227       4.227   1.063   1.964  1.00 94.28           C  \nATOM   1804  C   GLY A 227       4.749  -0.043   1.063  1.00 94.28           C  \nATOM   1805  O   GLY A 227       5.016   0.200  -0.107  1.00 94.28           O  \nATOM   1806  N   THR A 228       4.883  -1.266   1.586  1.00 91.11           N  \nATOM   1807  CA  THR A 228       5.219  -2.451   0.773  1.00 91.11           C  \nATOM   1808  C   THR A 228       4.225  -2.634  -0.380  1.00 91.11           C  \nATOM   1809  CB  THR A 228       5.240  -3.711   1.657  1.00 91.11           C  \nATOM   1810  O   THR A 228       4.643  -2.866  -1.511  1.00 91.11           O  \nATOM   1811  CG2 THR A 228       5.673  -4.979   0.928  1.00 91.11           C  \nATOM   1812  OG1 THR A 228       6.155  -3.512   2.709  1.00 91.11           O  \nATOM   1813  N   GLY A 229       2.934  -2.474  -0.085  1.00 93.07           N  \nATOM   1814  CA  GLY A 229       1.842  -2.415  -1.056  1.00 93.07           C  \nATOM   1815  C   GLY A 229       1.159  -1.046  -1.071  1.00 93.07           C  \nATOM   1816  O   GLY A 229       1.620  -0.115  -0.401  1.00 93.07           O  \nATOM   1817  N   CYS A 230       0.052  -0.933  -1.804  1.00 95.59           N  \nATOM   1818  CA  CYS A 230      -0.761   0.279  -1.845  1.00 95.59           C  \nATOM   1819  C   CYS A 230      -2.255  -0.053  -1.846  1.00 95.59           C  \nATOM   1820  CB  CYS A 230      -0.364   1.150  -3.043  1.00 95.59           C  \nATOM   1821  O   CYS A 230      -2.741  -0.684  -2.779  1.00 95.59           O  \nATOM   1822  SG  CYS A 230      -1.239   2.739  -2.931  1.00 95.59           S  \nATOM   1823  N   ASN A 231      -2.984   0.405  -0.827  1.00 97.28           N  \nATOM   1824  CA  ASN A 231      -4.427   0.193  -0.698  1.00 97.28           C  \nATOM   1825  C   ASN A 231      -5.110   1.403  -0.035  1.00 97.28           C  \nATOM   1826  CB  ASN A 231      -4.701  -1.132   0.034  1.00 97.28           C  \nATOM   1827  O   ASN A 231      -4.439   2.213   0.616  1.00 97.28           O  \nATOM   1828  CG  ASN A 231      -6.149  -1.574  -0.121  1.00 97.28           C  \nATOM   1829  ND2 ASN A 231      -6.643  -2.362   0.796  1.00 97.28           N  \nATOM   1830  OD1 ASN A 231      -6.848  -1.176  -1.043  1.00 97.28           O  \nATOM   1831  N   ALA A 232      -6.430   1.510  -0.174  1.00 98.35           N  \nATOM   1832  CA  ALA A 232      -7.242   2.478   0.549  1.00 98.35           C  \nATOM   1833  C   ALA A 232      -8.595   1.910   0.992  1.00 98.35           C  \nATOM   1834  CB  ALA A 232      -7.432   3.728  -0.313  1.00 98.35           C  \nATOM   1835  O   ALA A 232      -9.159   1.021   0.356  1.00 98.35           O  \nATOM   1836  N   CYS A 233      -9.145   2.496   2.048  1.00 98.12           N  \nATOM   1837  CA  CYS A 233     -10.540   2.367   2.446  1.00 98.12           C  \nATOM   1838  C   CYS A 233     -11.151   3.753   2.665  1.00 98.12           C  \nATOM   1839  CB  CYS A 233     -10.651   1.506   3.711  1.00 98.12           C  \nATOM   1840  O   CYS A 233     -10.427   4.731   2.863  1.00 98.12           O  \nATOM   1841  SG  CYS A 233     -10.082   2.442   5.159  1.00 98.12           S  \nATOM   1842  N   TYR A 234     -12.476   3.836   2.691  1.00 98.06           N  \nATOM   1843  CA  TYR A 234     -13.186   5.069   3.034  1.00 98.06           C  \nATOM   1844  C   TYR A 234     -14.588   4.784   3.578  1.00 98.06           C  \nATOM   1845  CB  TYR A 234     -13.247   5.999   1.812  1.00 98.06           C  \nATOM   1846  O   TYR A 234     -15.077   3.659   3.474  1.00 98.06           O  \nATOM   1847  CG  TYR A 234     -14.151   5.509   0.703  1.00 98.06           C  \nATOM   1848  CD1 TYR A 234     -13.730   4.458  -0.131  1.00 98.06           C  \nATOM   1849  CD2 TYR A 234     -15.424   6.082   0.528  1.00 98.06           C  \nATOM   1850  CE1 TYR A 234     -14.593   3.967  -1.123  1.00 98.06           C  \nATOM   1851  CE2 TYR A 234     -16.279   5.613  -0.484  1.00 98.06           C  \nATOM   1852  OH  TYR A 234     -16.693   4.055  -2.257  1.00 98.06           O  \nATOM   1853  CZ  TYR A 234     -15.867   4.542  -1.302  1.00 98.06           C  \nATOM   1854  N   MET A 235     -15.232   5.789   4.175  1.00 96.17           N  \nATOM   1855  CA  MET A 235     -16.636   5.710   4.598  1.00 96.17           C  \nATOM   1856  C   MET A 235     -17.583   5.975   3.419  1.00 96.17           C  \nATOM   1857  CB  MET A 235     -16.906   6.698   5.743  1.00 96.17           C  \nATOM   1858  O   MET A 235     -17.682   7.110   2.948  1.00 96.17           O  \nATOM   1859  CG  MET A 235     -16.178   6.334   7.043  1.00 96.17           C  \nATOM   1860  SD  MET A 235     -16.573   4.712   7.770  1.00 96.17           S  \nATOM   1861  CE  MET A 235     -18.368   4.828   7.984  1.00 96.17           C  \nATOM   1862  N   GLU A 236     -18.297   4.940   2.980  1.00 96.33           N  \nATOM   1863  CA  GLU A 236     -19.298   4.995   1.907  1.00 96.33           C  \nATOM   1864  C   GLU A 236     -20.724   5.034   2.481  1.00 96.33           C  \nATOM   1865  CB  GLU A 236     -19.079   3.796   0.963  1.00 96.33           C  \nATOM   1866  O   GLU A 236     -20.992   4.499   3.563  1.00 96.33           O  \nATOM   1867  CG  GLU A 236     -19.969   3.743  -0.291  1.00 96.33           C  \nATOM   1868  CD  GLU A 236     -19.869   4.986  -1.189  1.00 96.33           C  \nATOM   1869  OE1 GLU A 236     -20.601   5.970  -0.937  1.00 96.33           O  \nATOM   1870  OE2 GLU A 236     -19.076   4.962  -2.163  1.00 96.33           O  \nATOM   1871  N   GLU A 237     -21.640   5.665   1.746  1.00 95.22           N  \nATOM   1872  CA  GLU A 237     -23.070   5.679   2.067  1.00 95.22           C  \nATOM   1873  C   GLU A 237     -23.685   4.302   1.782  1.00 95.22           C  \nATOM   1874  CB  GLU A 237     -23.800   6.773   1.269  1.00 95.22           C  \nATOM   1875  O   GLU A 237     -23.511   3.756   0.692  1.00 95.22           O  \nATOM   1876  CG  GLU A 237     -23.233   8.195   1.431  1.00 95.22           C  \nATOM   1877  CD  GLU A 237     -23.203   8.685   2.888  1.00 95.22           C  \nATOM   1878  OE1 GLU A 237     -22.242   9.414   3.243  1.00 95.22           O  \nATOM   1879  OE2 GLU A 237     -24.106   8.305   3.668  1.00 95.22           O  \nATOM   1880  N   MET A 238     -24.431   3.734   2.735  1.00 94.83           N  \nATOM   1881  CA  MET A 238     -24.968   2.368   2.617  1.00 94.83           C  \nATOM   1882  C   MET A 238     -25.888   2.181   1.407  1.00 94.83           C  \nATOM   1883  CB  MET A 238     -25.717   1.985   3.898  1.00 94.83           C  \nATOM   1884  O   MET A 238     -25.868   1.120   0.794  1.00 94.83           O  \nATOM   1885  CG  MET A 238     -24.775   1.519   5.010  1.00 94.83           C  \nATOM   1886  SD  MET A 238     -23.848  -0.010   4.697  1.00 94.83           S  \nATOM   1887  CE  MET A 238     -25.178  -1.162   4.262  1.00 94.83           C  \nATOM   1888  N   GLN A 239     -26.612   3.225   0.993  1.00 95.01           N  \nATOM   1889  CA  GLN A 239     -27.411   3.222  -0.239  1.00 95.01           C  \nATOM   1890  C   GLN A 239     -26.606   2.885  -1.513  1.00 95.01           C  \nATOM   1891  CB  GLN A 239     -28.106   4.587  -0.390  1.00 95.01           C  \nATOM   1892  O   GLN A 239     -27.194   2.500  -2.519  1.00 95.01           O  \nATOM   1893  CG  GLN A 239     -27.111   5.742  -0.602  1.00 95.01           C  \nATOM   1894  CD  GLN A 239     -27.787   7.080  -0.863  1.00 95.01           C  \nATOM   1895  NE2 GLN A 239     -27.333   7.815  -1.855  1.00 95.01           N  \nATOM   1896  OE1 GLN A 239     -28.713   7.502  -0.191  1.00 95.01           O  \nATOM   1897  N   ASN A 240     -25.277   3.044  -1.486  1.00 95.87           N  \nATOM   1898  CA  ASN A 240     -24.388   2.727  -2.602  1.00 95.87           C  \nATOM   1899  C   ASN A 240     -23.775   1.318  -2.492  1.00 95.87           C  \nATOM   1900  CB  ASN A 240     -23.276   3.792  -2.680  1.00 95.87           C  \nATOM   1901  O   ASN A 240     -23.098   0.898  -3.424  1.00 95.87           O  \nATOM   1902  CG  ASN A 240     -23.768   5.212  -2.893  1.00 95.87           C  \nATOM   1903  ND2 ASN A 240     -23.052   6.188  -2.386  1.00 95.87           N  \nATOM   1904  OD1 ASN A 240     -24.770   5.487  -3.534  1.00 95.87           O  \nATOM   1905  N   VAL A 241     -23.950   0.607  -1.370  1.00 95.90           N  \nATOM   1906  CA  VAL A 241     -23.299  -0.683  -1.084  1.00 95.90           C  \nATOM   1907  C   VAL A 241     -24.302  -1.825  -1.267  1.00 95.90           C  \nATOM   1908  CB  VAL A 241     -22.658  -0.701   0.326  1.00 95.90           C  \nATOM   1909  O   VAL A 241     -24.852  -2.346  -0.303  1.00 95.90           O  \nATOM   1910  CG1 VAL A 241     -21.804  -1.966   0.527  1.00 95.90           C  \nATOM   1911  CG2 VAL A 241     -21.739   0.503   0.585  1.00 95.90           C  \nATOM   1912  N   GLU A 242     -24.513  -2.271  -2.507  1.00 96.47           N  \nATOM   1913  CA  GLU A 242     -25.487  -3.338  -2.819  1.00 96.47           C  \nATOM   1914  C   GLU A 242     -25.071  -4.729  -2.298  1.00 96.47           C  \nATOM   1915  CB  GLU A 242     -25.709  -3.423  -4.335  1.00 96.47           C  \nATOM   1916  O   GLU A 242     -25.857  -5.674  -2.317  1.00 96.47           O  \nATOM   1917  CG  GLU A 242     -26.308  -2.156  -4.969  1.00 96.47           C  \nATOM   1918  CD  GLU A 242     -26.504  -2.300  -6.490  1.00 96.47           C  \nATOM   1919  OE1 GLU A 242     -26.937  -1.310  -7.124  1.00 96.47           O  \nATOM   1920  OE2 GLU A 242     -26.171  -3.379  -7.043  1.00 96.47           O  \nATOM   1921  N   LEU A 243     -23.824  -4.869  -1.838  1.00 93.58           N  \nATOM   1922  CA  LEU A 243     -23.253  -6.121  -1.331  1.00 93.58           C  \nATOM   1923  C   LEU A 243     -23.720  -6.488   0.084  1.00 93.58           C  \nATOM   1924  CB  LEU A 243     -21.722  -6.002  -1.341  1.00 93.58           C  \nATOM   1925  O   LEU A 243     -23.450  -7.597   0.547  1.00 93.58           O  \nATOM   1926  CG  LEU A 243     -21.099  -5.677  -2.705  1.00 93.58           C  \nATOM   1927  CD1 LEU A 243     -19.595  -5.517  -2.512  1.00 93.58           C  \nATOM   1928  CD2 LEU A 243     -21.372  -6.768  -3.741  1.00 93.58           C  \nATOM   1929  N   VAL A 244     -24.358  -5.557   0.795  1.00 92.30           N  \nATOM   1930  CA  VAL A 244     -24.839  -5.748   2.166  1.00 92.30           C  \nATOM   1931  C   VAL A 244     -26.299  -5.324   2.235  1.00 92.30           C  \nATOM   1932  CB  VAL A 244     -23.983  -4.964   3.179  1.00 92.30           C  \nATOM   1933  O   VAL A 244     -26.692  -4.325   1.646  1.00 92.30           O  \nATOM   1934  CG1 VAL A 244     -24.454  -5.193   4.623  1.00 92.30           C  \nATOM   1935  CG2 VAL A 244     -22.508  -5.382   3.119  1.00 92.30           C  \nATOM   1936  N   GLU A 245     -27.113  -6.071   2.979  1.00 91.11           N  \nATOM   1937  CA  GLU A 245     -28.515  -5.709   3.176  1.00 91.11           C  \nATOM   1938  C   GLU A 245     -28.671  -4.416   4.002  1.00 91.11           C  \nATOM   1939  CB  GLU A 245     -29.300  -6.868   3.812  1.00 91.11           C  \nATOM   1940  O   GLU A 245     -28.004  -4.203   5.026  1.00 91.11           O  \nATOM   1941  CG  GLU A 245     -29.395  -8.107   2.901  1.00 91.11           C  \nATOM   1942  CD  GLU A 245     -30.291  -9.222   3.476  1.00 91.11           C  \nATOM   1943  OE1 GLU A 245     -30.542 -10.202   2.737  1.00 91.11           O  \nATOM   1944  OE2 GLU A 245     -30.728  -9.105   4.645  1.00 91.11           O  \nATOM   1945  N   GLY A 246     -29.621  -3.583   3.568  1.00 91.34           N  \nATOM   1946  CA  GLY A 246     -29.977  -2.304   4.185  1.00 91.34           C  \nATOM   1947  C   GLY A 246     -29.236  -1.106   3.587  1.00 91.34           C  \nATOM   1948  O   GLY A 246     -28.090  -1.208   3.172  1.00 91.34           O  \nATOM   1949  N   ASP A 247     -29.897   0.047   3.583  1.00 91.55           N  \nATOM   1950  CA  ASP A 247     -29.433   1.309   2.991  1.00 91.55           C  \nATOM   1951  C   ASP A 247     -29.157   2.407   4.038  1.00 91.55           C  \nATOM   1952  CB  ASP A 247     -30.459   1.764   1.936  1.00 91.55           C  \nATOM   1953  O   ASP A 247     -28.713   3.503   3.696  1.00 91.55           O  \nATOM   1954  CG  ASP A 247     -31.891   1.961   2.465  1.00 91.55           C  \nATOM   1955  OD1 ASP A 247     -32.155   1.604   3.639  1.00 91.55           O  \nATOM   1956  OD2 ASP A 247     -32.740   2.406   1.662  1.00 91.55           O  \nATOM   1957  N   GLU A 248     -29.372   2.116   5.325  1.00 91.74           N  \nATOM   1958  CA  GLU A 248     -29.239   3.094   6.405  1.00 91.74           C  \nATOM   1959  C   GLU A 248     -27.797   3.289   6.895  1.00 91.74           C  \nATOM   1960  CB  GLU A 248     -30.131   2.738   7.602  1.00 91.74           C  \nATOM   1961  O   GLU A 248     -27.109   2.355   7.329  1.00 91.74           O  \nATOM   1962  CG  GLU A 248     -31.636   2.827   7.303  1.00 91.74           C  \nATOM   1963  CD  GLU A 248     -32.502   2.697   8.570  1.00 91.74           C  \nATOM   1964  OE1 GLU A 248     -33.730   2.924   8.469  1.00 91.74           O  \nATOM   1965  OE2 GLU A 248     -31.945   2.396   9.654  1.00 91.74           O  \nATOM   1966  N   GLY A 249     -27.385   4.556   6.945  1.00 92.95           N  \nATOM   1967  CA  GLY A 249     -26.119   4.985   7.525  1.00 92.95           C  \nATOM   1968  C   GLY A 249     -24.937   4.790   6.581  1.00 92.95           C  \nATOM   1969  O   GLY A 249     -25.057   4.897   5.364  1.00 92.95           O  \nATOM   1970  N   ARG A 250     -23.762   4.542   7.163  1.00 93.49           N  \nATOM   1971  CA  ARG A 250     -22.491   4.471   6.435  1.00 93.49           C  \nATOM   1972  C   ARG A 250     -21.715   3.228   6.832  1.00 93.49           C  \nATOM   1973  CB  ARG A 250     -21.678   5.759   6.655  1.00 93.49           C  \nATOM   1974  O   ARG A 250     -21.830   2.748   7.962  1.00 93.49           O  \nATOM   1975  CG  ARG A 250     -22.411   6.992   6.098  1.00 93.49           C  \nATOM   1976  CD  ARG A 250     -21.650   8.301   6.306  1.00 93.49           C  \nATOM   1977  NE  ARG A 250     -21.483   8.639   7.739  1.00 93.49           N  \nATOM   1978  NH1 ARG A 250     -19.907  10.250   7.401  1.00 93.49           N  \nATOM   1979  NH2 ARG A 250     -20.436   9.685   9.486  1.00 93.49           N  \nATOM   1980  CZ  ARG A 250     -20.619   9.522   8.207  1.00 93.49           C  \nATOM   1981  N   MET A 251     -20.891   2.732   5.921  1.00 94.49           N  \nATOM   1982  CA  MET A 251     -19.983   1.622   6.183  1.00 94.49           C  \nATOM   1983  C   MET A 251     -18.611   1.921   5.598  1.00 94.49           C  \nATOM   1984  CB  MET A 251     -20.580   0.315   5.644  1.00 94.49           C  \nATOM   1985  O   MET A 251     -18.487   2.467   4.505  1.00 94.49           O  \nATOM   1986  CG  MET A 251     -19.678  -0.891   5.927  1.00 94.49           C  \nATOM   1987  SD  MET A 251     -20.291  -2.505   5.388  1.00 94.49           S  \nATOM   1988  CE  MET A 251     -21.765  -2.695   6.410  1.00 94.49           C  \nATOM   1989  N   CYS A 252     -17.566   1.542   6.329  1.00 95.98           N  \nATOM   1990  CA  CYS A 252     -16.228   1.557   5.773  1.00 95.98           C  \nATOM   1991  C   CYS A 252     -16.102   0.474   4.694  1.00 95.98           C  \nATOM   1992  CB  CYS A 252     -15.199   1.412   6.892  1.00 95.98           C  \nATOM   1993  O   CYS A 252     -16.375  -0.706   4.940  1.00 95.98           O  \nATOM   1994  SG  CYS A 252     -13.547   1.624   6.181  1.00 95.98           S  \nATOM   1995  N   VAL A 253     -15.669   0.875   3.506  1.00 97.54           N  \nATOM   1996  CA  VAL A 253     -15.423  -0.009   2.371  1.00 97.54           C  \nATOM   1997  C   VAL A 253     -13.928  -0.042   2.100  1.00 97.54           C  \nATOM   1998  CB  VAL A 253     -16.227   0.445   1.142  1.00 97.54           C  \nATOM   1999  O   VAL A 253     -13.291   1.000   1.945  1.00 97.54           O  \nATOM   2000  CG1 VAL A 253     -15.889  -0.419  -0.074  1.00 97.54           C  \nATOM   2001  CG2 VAL A 253     -17.732   0.309   1.410  1.00 97.54           C  \nATOM   2002  N   ASN A 254     -13.367  -1.245   2.043  1.00 97.72           N  \nATOM   2003  CA  ASN A 254     -11.996  -1.473   1.616  1.00 97.72           C  \nATOM   2004  C   ASN A 254     -11.971  -1.602   0.090  1.00 97.72           C  \nATOM   2005  CB  ASN A 254     -11.473  -2.717   2.342  1.00 97.72           C  \nATOM   2006  O   ASN A 254     -12.585  -2.506  -0.470  1.00 97.72           O  \nATOM   2007  CG  ASN A 254     -10.074  -3.102   1.914  1.00 97.72           C  \nATOM   2008  ND2 ASN A 254      -9.595  -4.198   2.439  1.00 97.72           N  \nATOM   2009  OD1 ASN A 254      -9.419  -2.448   1.117  1.00 97.72           O  \nATOM   2010  N   THR A 255     -11.278  -0.697  -0.595  1.00 98.21           N  \nATOM   2011  CA  THR A 255     -11.315  -0.648  -2.062  1.00 98.21           C  \nATOM   2012  C   THR A 255     -10.654  -1.868  -2.701  1.00 98.21           C  \nATOM   2013  CB  THR A 255     -10.670   0.634  -2.611  1.00 98.21           C  \nATOM   2014  O   THR A 255     -11.110  -2.319  -3.752  1.00 98.21           O  \nATOM   2015  CG2 THR A 255     -11.329   1.906  -2.072  1.00 98.21           C  \nATOM   2016  OG1 THR A 255      -9.298   0.695  -2.295  1.00 98.21           O  \nATOM   2017  N   GLU A 256      -9.601  -2.405  -2.072  1.00 96.76           N  \nATOM   2018  CA  GLU A 256      -8.670  -3.360  -2.688  1.00 96.76           C  \nATOM   2019  C   GLU A 256      -8.231  -2.903  -4.091  1.00 96.76           C  \nATOM   2020  CB  GLU A 256      -9.217  -4.798  -2.634  1.00 96.76           C  \nATOM   2021  O   GLU A 256      -8.126  -3.687  -5.035  1.00 96.76           O  \nATOM   2022  CG  GLU A 256      -9.296  -5.369  -1.209  1.00 96.76           C  \nATOM   2023  CD  GLU A 256      -7.940  -5.459  -0.484  1.00 96.76           C  \nATOM   2024  OE1 GLU A 256      -7.940  -5.511   0.769  1.00 96.76           O  \nATOM   2025  OE2 GLU A 256      -6.891  -5.515  -1.160  1.00 96.76           O  \nATOM   2026  N   TRP A 257      -7.966  -1.599  -4.243  1.00 97.81           N  \nATOM   2027  CA  TRP A 257      -7.658  -0.981  -5.536  1.00 97.81           C  \nATOM   2028  C   TRP A 257      -6.321  -1.426  -6.142  1.00 97.81           C  \nATOM   2029  CB  TRP A 257      -7.731   0.544  -5.403  1.00 97.81           C  \nATOM   2030  O   TRP A 257      -5.963  -0.993  -7.234  1.00 97.81           O  \nATOM   2031  CG  TRP A 257      -6.690   1.240  -4.568  1.00 97.81           C  \nATOM   2032  CD1 TRP A 257      -5.538   0.722  -4.075  1.00 97.81           C  \nATOM   2033  CD2 TRP A 257      -6.690   2.632  -4.131  1.00 97.81           C  \nATOM   2034  CE2 TRP A 257      -5.485   2.880  -3.410  1.00 97.81           C  \nATOM   2035  CE3 TRP A 257      -7.573   3.721  -4.278  1.00 97.81           C  \nATOM   2036  NE1 TRP A 257      -4.802   1.699  -3.456  1.00 97.81           N  \nATOM   2037  CH2 TRP A 257      -6.069   5.181  -3.014  1.00 97.81           C  \nATOM   2038  CZ2 TRP A 257      -5.161   4.121  -2.866  1.00 97.81           C  \nATOM   2039  CZ3 TRP A 257      -7.265   4.977  -3.721  1.00 97.81           C  \nATOM   2040  N   GLY A 258      -5.555  -2.270  -5.441  1.00 96.80           N  \nATOM   2041  CA  GLY A 258      -4.263  -2.761  -5.907  1.00 96.80           C  \nATOM   2042  C   GLY A 258      -4.404  -3.567  -7.197  1.00 96.80           C  \nATOM   2043  O   GLY A 258      -3.517  -3.498  -8.046  1.00 96.80           O  \nATOM   2044  N   ALA A 259      -5.551  -4.235  -7.369  1.00 96.71           N  \nATOM   2045  CA  ALA A 259      -5.952  -4.993  -8.555  1.00 96.71           C  \nATOM   2046  C   ALA A 259      -6.477  -4.122  -9.712  1.00 96.71           C  \nATOM   2047  CB  ALA A 259      -6.992  -6.021  -8.097  1.00 96.71           C  \nATOM   2048  O   ALA A 259      -6.822  -4.633 -10.775  1.00 96.71           O  \nATOM   2049  N   PHE A 260      -6.553  -2.798  -9.549  1.00 98.45           N  \nATOM   2050  CA  PHE A 260      -6.910  -1.921 -10.658  1.00 98.45           C  \nATOM   2051  C   PHE A 260      -5.923  -2.093 -11.826  1.00 98.45           C  \nATOM   2052  CB  PHE A 260      -6.998  -0.480 -10.157  1.00 98.45           C  \nATOM   2053  O   PHE A 260      -4.708  -2.102 -11.634  1.00 98.45           O  \nATOM   2054  CG  PHE A 260      -7.327   0.533 -11.226  1.00 98.45           C  \nATOM   2055  CD1 PHE A 260      -6.460   1.617 -11.433  1.00 98.45           C  \nATOM   2056  CD2 PHE A 260      -8.499   0.415 -11.996  1.00 98.45           C  \nATOM   2057  CE1 PHE A 260      -6.770   2.582 -12.398  1.00 98.45           C  \nATOM   2058  CE2 PHE A 260      -8.793   1.371 -12.981  1.00 98.45           C  \nATOM   2059  CZ  PHE A 260      -7.920   2.451 -13.188  1.00 98.45           C  \nATOM   2060  N   GLY A 261      -6.442  -2.251 -13.043  1.00 97.78           N  \nATOM   2061  CA  GLY A 261      -5.640  -2.551 -14.229  1.00 97.78           C  \nATOM   2062  C   GLY A 261      -5.601  -4.029 -14.606  1.00 97.78           C  \nATOM   2063  O   GLY A 261      -5.274  -4.316 -15.756  1.00 97.78           O  \nATOM   2064  N   ASP A 262      -5.965  -4.950 -13.705  1.00 96.60           N  \nATOM   2065  CA  ASP A 262      -5.951  -6.397 -13.967  1.00 96.60           C  \nATOM   2066  C   ASP A 262      -6.902  -6.796 -15.121  1.00 96.60           C  \nATOM   2067  CB  ASP A 262      -6.297  -7.176 -12.676  1.00 96.60           C  \nATOM   2068  O   ASP A 262      -6.708  -7.839 -15.744  1.00 96.60           O  \nATOM   2069  CG  ASP A 262      -5.263  -7.084 -11.532  1.00 96.60           C  \nATOM   2070  OD1 ASP A 262      -4.224  -6.389 -11.650  1.00 96.60           O  \nATOM   2071  OD2 ASP A 262      -5.468  -7.737 -10.479  1.00 96.60           O  \nATOM   2072  N   SER A 263      -7.896  -5.957 -15.459  1.00 96.14           N  \nATOM   2073  CA  SER A 263      -8.797  -6.155 -16.610  1.00 96.14           C  \nATOM   2074  C   SER A 263      -8.514  -5.191 -17.776  1.00 96.14           C  \nATOM   2075  CB  SER A 263     -10.268  -6.125 -16.185  1.00 96.14           C  \nATOM   2076  O   SER A 263      -9.381  -4.951 -18.621  1.00 96.14           O  \nATOM   2077  OG  SER A 263     -10.502  -7.039 -15.134  1.00 96.14           O  \nATOM   2078  N   GLY A 264      -7.296  -4.643 -17.851  1.00 97.16           N  \nATOM   2079  CA  GLY A 264      -6.818  -3.802 -18.956  1.00 97.16           C  \nATOM   2080  C   GLY A 264      -7.079  -2.302 -18.785  1.00 97.16           C  \nATOM   2081  O   GLY A 264      -6.789  -1.509 -19.683  1.00 97.16           O  \nATOM   2082  N   GLU A 265      -7.583  -1.853 -17.630  1.00 98.06           N  \nATOM   2083  CA  GLU A 265      -7.887  -0.436 -17.378  1.00 98.06           C  \nATOM   2084  C   GLU A 265      -6.649   0.467 -17.447  1.00 98.06           C  \nATOM   2085  CB  GLU A 265      -8.536  -0.229 -16.001  1.00 98.06           C  \nATOM   2086  O   GLU A 265      -6.768   1.675 -17.686  1.00 98.06           O  \nATOM   2087  CG  GLU A 265      -9.840  -1.006 -15.787  1.00 98.06           C  \nATOM   2088  CD  GLU A 265      -9.653  -2.440 -15.266  1.00 98.06           C  \nATOM   2089  OE1 GLU A 265     -10.686  -3.038 -14.924  1.00 98.06           O  \nATOM   2090  OE2 GLU A 265      -8.503  -2.945 -15.240  1.00 98.06           O  \nATOM   2091  N   LEU A 266      -5.466  -0.114 -17.240  1.00 97.86           N  \nATOM   2092  CA  LEU A 266      -4.183   0.579 -17.202  1.00 97.86           C  \nATOM   2093  C   LEU A 266      -3.289   0.299 -18.413  1.00 97.86           C  \nATOM   2094  CB  LEU A 266      -3.471   0.252 -15.876  1.00 97.86           C  \nATOM   2095  O   LEU A 266      -2.186   0.836 -18.452  1.00 97.86           O  \nATOM   2096  CG  LEU A 266      -4.158   0.841 -14.632  1.00 97.86           C  \nATOM   2097  CD1 LEU A 266      -3.342   0.483 -13.395  1.00 97.86           C  \nATOM   2098  CD2 LEU A 266      -4.250   2.369 -14.718  1.00 97.86           C  \nATOM   2099  N   ASP A 267      -3.738  -0.468 -19.413  1.00 98.02           N  \nATOM   2100  CA  ASP A 267      -2.878  -0.949 -20.507  1.00 98.02           C  \nATOM   2101  C   ASP A 267      -2.108   0.159 -21.240  1.00 98.02           C  \nATOM   2102  CB  ASP A 267      -3.721  -1.728 -21.535  1.00 98.02           C  \nATOM   2103  O   ASP A 267      -0.954  -0.051 -21.616  1.00 98.02           O  \nATOM   2104  CG  ASP A 267      -3.889  -3.213 -21.209  1.00 98.02           C  \nATOM   2105  OD1 ASP A 267      -3.043  -3.739 -20.450  1.00 98.02           O  \nATOM   2106  OD2 ASP A 267      -4.796  -3.822 -21.812  1.00 98.02           O  \nATOM   2107  N   GLU A 268      -2.713   1.342 -21.409  1.00 97.04           N  \nATOM   2108  CA  GLU A 268      -2.069   2.492 -22.068  1.00 97.04           C  \nATOM   2109  C   GLU A 268      -0.940   3.131 -21.235  1.00 97.04           C  \nATOM   2110  CB  GLU A 268      -3.121   3.541 -22.513  1.00 97.04           C  \nATOM   2111  O   GLU A 268      -0.135   3.877 -21.783  1.00 97.04           O  \nATOM   2112  CG  GLU A 268      -3.566   4.502 -21.396  1.00 97.04           C  \nATOM   2113  CD  GLU A 268      -4.639   5.536 -21.801  1.00 97.04           C  \nATOM   2114  OE1 GLU A 268      -5.689   5.561 -21.126  1.00 97.04           O  \nATOM   2115  OE2 GLU A 268      -4.503   6.356 -22.742  1.00 97.04           O  \nATOM   2116  N   PHE A 269      -0.885   2.859 -19.927  1.00 97.82           N  \nATOM   2117  CA  PHE A 269       0.069   3.446 -18.979  1.00 97.82           C  \nATOM   2118  C   PHE A 269       1.158   2.462 -18.523  1.00 97.82           C  \nATOM   2119  CB  PHE A 269      -0.696   4.001 -17.765  1.00 97.82           C  \nATOM   2120  O   PHE A 269       2.103   2.876 -17.851  1.00 97.82           O  \nATOM   2121  CG  PHE A 269      -1.818   4.966 -18.098  1.00 97.82           C  \nATOM   2122  CD1 PHE A 269      -1.528   6.207 -18.696  1.00 97.82           C  \nATOM   2123  CD2 PHE A 269      -3.155   4.614 -17.836  1.00 97.82           C  \nATOM   2124  CE1 PHE A 269      -2.571   7.082 -19.043  1.00 97.82           C  \nATOM   2125  CE2 PHE A 269      -4.197   5.501 -18.157  1.00 97.82           C  \nATOM   2126  CZ  PHE A 269      -3.902   6.735 -18.760  1.00 97.82           C  \nATOM   2127  N   LEU A 270       1.030   1.172 -18.859  1.00 98.20           N  \nATOM   2128  CA  LEU A 270       2.002   0.137 -18.500  1.00 98.20           C  \nATOM   2129  C   LEU A 270       3.204   0.156 -19.453  1.00 98.20           C  \nATOM   2130  CB  LEU A 270       1.331  -1.250 -18.498  1.00 98.20           C  \nATOM   2131  O   LEU A 270       3.077  -0.166 -20.639  1.00 98.20           O  \nATOM   2132  CG  LEU A 270       0.242  -1.474 -17.436  1.00 98.20           C  \nATOM   2133  CD1 LEU A 270      -0.336  -2.879 -17.590  1.00 98.20           C  \nATOM   2134  CD2 LEU A 270       0.761  -1.310 -16.009  1.00 98.20           C  \nATOM   2135  N   LEU A 271       4.379   0.470 -18.906  1.00 98.45           N  \nATOM   2136  CA  LEU A 271       5.666   0.434 -19.603  1.00 98.45           C  \nATOM   2137  C   LEU A 271       6.234  -0.991 -19.658  1.00 98.45           C  \nATOM   2138  CB  LEU A 271       6.662   1.391 -18.917  1.00 98.45           C  \nATOM   2139  O   LEU A 271       5.788  -1.891 -18.943  1.00 98.45           O  \nATOM   2140  CG  LEU A 271       6.203   2.855 -18.789  1.00 98.45           C  \nATOM   2141  CD1 LEU A 271       7.339   3.685 -18.185  1.00 98.45           C  \nATOM   2142  CD2 LEU A 271       5.819   3.466 -20.135  1.00 98.45           C  \nATOM   2143  N   GLU A 272       7.276  -1.198 -20.470  1.00 98.04           N  \nATOM   2144  CA  GLU A 272       7.961  -2.498 -20.566  1.00 98.04           C  \nATOM   2145  C   GLU A 272       8.487  -2.991 -19.207  1.00 98.04           C  \nATOM   2146  CB  GLU A 272       9.079  -2.445 -21.627  1.00 98.04           C  \nATOM   2147  O   GLU A 272       8.361  -4.169 -18.877  1.00 98.04           O  \nATOM   2148  CG  GLU A 272      10.266  -1.503 -21.322  1.00 98.04           C  \nATOM   2149  CD  GLU A 272      11.382  -1.551 -22.390  1.00 98.04           C  \nATOM   2150  OE1 GLU A 272      12.395  -0.827 -22.232  1.00 98.04           O  \nATOM   2151  OE2 GLU A 272      11.247  -2.332 -23.359  1.00 98.04           O  \nATOM   2152  N   TYR A 273       8.988  -2.076 -18.371  1.00 98.48           N  \nATOM   2153  CA  TYR A 273       9.506  -2.386 -17.037  1.00 98.48           C  \nATOM   2154  C   TYR A 273       8.415  -2.924 -16.105  1.00 98.48           C  \nATOM   2155  CB  TYR A 273      10.134  -1.123 -16.426  1.00 98.48           C  \nATOM   2156  O   TYR A 273       8.669  -3.834 -15.318  1.00 98.48           O  \nATOM   2157  CG  TYR A 273      10.944  -0.288 -17.399  1.00 98.48           C  \nATOM   2158  CD1 TYR A 273      12.227  -0.703 -17.796  1.00 98.48           C  \nATOM   2159  CD2 TYR A 273      10.380   0.875 -17.958  1.00 98.48           C  \nATOM   2160  CE1 TYR A 273      12.960   0.064 -18.720  1.00 98.48           C  \nATOM   2161  CE2 TYR A 273      11.100   1.629 -18.902  1.00 98.48           C  \nATOM   2162  OH  TYR A 273      13.087   1.988 -20.168  1.00 98.48           O  \nATOM   2163  CZ  TYR A 273      12.397   1.231 -19.279  1.00 98.48           C  \nATOM   2164  N   ASP A 274       7.197  -2.390 -16.217  1.00 98.54           N  \nATOM   2165  CA  ASP A 274       6.060  -2.796 -15.387  1.00 98.54           C  \nATOM   2166  C   ASP A 274       5.639  -4.225 -15.722  1.00 98.54           C  \nATOM   2167  CB  ASP A 274       4.884  -1.830 -15.592  1.00 98.54           C  \nATOM   2168  O   ASP A 274       5.402  -5.035 -14.826  1.00 98.54           O  \nATOM   2169  CG  ASP A 274       5.280  -0.378 -15.344  1.00 98.54           C  \nATOM   2170  OD1 ASP A 274       6.015  -0.100 -14.375  1.00 98.54           O  \nATOM   2171  OD2 ASP A 274       4.887   0.508 -16.131  1.00 98.54           O  \nATOM   2172  N   ARG A 275       5.633  -4.555 -17.019  1.00 98.30           N  \nATOM   2173  CA  ARG A 275       5.326  -5.899 -17.519  1.00 98.30           C  \nATOM   2174  C   ARG A 275       6.375  -6.911 -17.065  1.00 98.30           C  \nATOM   2175  CB  ARG A 275       5.174  -5.872 -19.048  1.00 98.30           C  \nATOM   2176  O   ARG A 275       6.015  -7.959 -16.547  1.00 98.30           O  \nATOM   2177  CG  ARG A 275       4.015  -4.956 -19.475  1.00 98.30           C  \nATOM   2178  CD  ARG A 275       3.858  -4.901 -20.998  1.00 98.30           C  \nATOM   2179  NE  ARG A 275       2.940  -3.814 -21.398  1.00 98.30           N  \nATOM   2180  NH1 ARG A 275       0.916  -4.865 -21.028  1.00 98.30           N  \nATOM   2181  NH2 ARG A 275       0.957  -2.754 -21.732  1.00 98.30           N  \nATOM   2182  CZ  ARG A 275       1.616  -3.824 -21.389  1.00 98.30           C  \nATOM   2183  N   LEU A 276       7.663  -6.567 -17.131  1.00 98.10           N  \nATOM   2184  CA  LEU A 276       8.739  -7.432 -16.626  1.00 98.10           C  \nATOM   2185  C   LEU A 276       8.645  -7.674 -15.109  1.00 98.10           C  \nATOM   2186  CB  LEU A 276      10.094  -6.795 -16.972  1.00 98.10           C  \nATOM   2187  O   LEU A 276       8.878  -8.792 -14.634  1.00 98.10           O  \nATOM   2188  CG  LEU A 276      10.466  -6.829 -18.464  1.00 98.10           C  \nATOM   2189  CD1 LEU A 276      11.753  -6.026 -18.669  1.00 98.10           C  \nATOM   2190  CD2 LEU A 276      10.705  -8.254 -18.967  1.00 98.10           C  \nATOM   2191  N   VAL A 277       8.300  -6.643 -14.329  1.00 98.15           N  \nATOM   2192  CA  VAL A 277       8.047  -6.792 -12.886  1.00 98.15           C  \nATOM   2193  C   VAL A 277       6.864  -7.719 -12.634  1.00 98.15           C  \nATOM   2194  CB  VAL A 277       7.816  -5.425 -12.211  1.00 98.15           C  \nATOM   2195  O   VAL A 277       6.956  -8.594 -11.769  1.00 98.15           O  \nATOM   2196  CG1 VAL A 277       7.245  -5.540 -10.791  1.00 98.15           C  \nATOM   2197  CG2 VAL A 277       9.152  -4.703 -12.076  1.00 98.15           C  \nATOM   2198  N   ASP A 278       5.776  -7.544 -13.382  1.00 97.23           N  \nATOM   2199  CA  ASP A 278       4.562  -8.341 -13.261  1.00 97.23           C  \nATOM   2200  C   ASP A 278       4.784  -9.817 -13.621  1.00 97.23           C  \nATOM   2201  CB  ASP A 278       3.455  -7.721 -14.122  1.00 97.23           C  \nATOM   2202  O   ASP A 278       4.536 -10.689 -12.785  1.00 97.23           O  \nATOM   2203  CG  ASP A 278       2.202  -8.581 -14.029  1.00 97.23           C  \nATOM   2204  OD1 ASP A 278       1.765  -8.816 -12.883  1.00 97.23           O  \nATOM   2205  OD2 ASP A 278       1.729  -9.105 -15.051  1.00 97.23           O  \nATOM   2206  N   GLU A 279       5.335 -10.093 -14.804  1.00 97.16           N  \nATOM   2207  CA  GLU A 279       5.606 -11.440 -15.327  1.00 97.16           C  \nATOM   2208  C   GLU A 279       6.470 -12.269 -14.378  1.00 97.16           C  \nATOM   2209  CB  GLU A 279       6.371 -11.318 -16.652  1.00 97.16           C  \nATOM   2210  O   GLU A 279       6.290 -13.477 -14.222  1.00 97.16           O  \nATOM   2211  CG  GLU A 279       5.481 -10.901 -17.831  1.00 97.16           C  \nATOM   2212  CD  GLU A 279       6.294 -10.577 -19.096  1.00 97.16           C  \nATOM   2213  OE1 GLU A 279       5.681 -10.053 -20.054  1.00 97.16           O  \nATOM   2214  OE2 GLU A 279       7.513 -10.876 -19.124  1.00 97.16           O  \nATOM   2215  N   SER A 280       7.419 -11.610 -13.720  1.00 93.40           N  \nATOM   2216  CA  SER A 280       8.335 -12.260 -12.796  1.00 93.40           C  \nATOM   2217  C   SER A 280       7.784 -12.325 -11.362  1.00 93.40           C  \nATOM   2218  CB  SER A 280       9.701 -11.581 -12.934  1.00 93.40           C  \nATOM   2219  O   SER A 280       8.391 -12.952 -10.488  1.00 93.40           O  \nATOM   2220  OG  SER A 280       9.684 -10.234 -12.495  1.00 93.40           O  \nATOM   2221  N   SER A 281       6.676 -11.647 -11.054  1.00 91.88           N  \nATOM   2222  CA  SER A 281       6.115 -11.562  -9.700  1.00 91.88           C  \nATOM   2223  C   SER A 281       5.527 -12.890  -9.200  1.00 91.88           C  \nATOM   2224  CB  SER A 281       5.074 -10.441  -9.620  1.00 91.88           C  \nATOM   2225  O   SER A 281       5.396 -13.873  -9.924  1.00 91.88           O  \nATOM   2226  OG  SER A 281       3.869 -10.853 -10.217  1.00 91.88           O  \nATOM   2227  N   ALA A 282       5.154 -12.926  -7.919  1.00 85.51           N  \nATOM   2228  CA  ALA A 282       4.499 -14.086  -7.315  1.00 85.51           C  \nATOM   2229  C   ALA A 282       3.087 -14.349  -7.875  1.00 85.51           C  \nATOM   2230  CB  ALA A 282       4.453 -13.843  -5.802  1.00 85.51           C  \nATOM   2231  O   ALA A 282       2.582 -15.464  -7.715  1.00 85.51           O  \nATOM   2232  N   ASN A 283       2.484 -13.332  -8.489  1.00 88.03           N  \nATOM   2233  CA  ASN A 283       1.105 -13.255  -8.949  1.00 88.03           C  \nATOM   2234  C   ASN A 283       1.030 -12.463 -10.277  1.00 88.03           C  \nATOM   2235  CB  ASN A 283       0.261 -12.631  -7.811  1.00 88.03           C  \nATOM   2236  O   ASN A 283       0.561 -11.323 -10.268  1.00 88.03           O  \nATOM   2237  CG  ASN A 283       0.723 -11.254  -7.330  1.00 88.03           C  \nATOM   2238  ND2 ASN A 283      -0.206 -10.380  -7.029  1.00 88.03           N  \nATOM   2239  OD1 ASN A 283       1.905 -10.956  -7.174  1.00 88.03           O  \nATOM   2240  N   PRO A 284       1.546 -13.006 -11.398  1.00 94.19           N  \nATOM   2241  CA  PRO A 284       1.499 -12.335 -12.701  1.00 94.19           C  \nATOM   2242  C   PRO A 284       0.066 -12.041 -13.155  1.00 94.19           C  \nATOM   2243  CB  PRO A 284       2.210 -13.269 -13.685  1.00 94.19           C  \nATOM   2244  O   PRO A 284      -0.837 -12.841 -12.900  1.00 94.19           O  \nATOM   2245  CG  PRO A 284       3.109 -14.115 -12.787  1.00 94.19           C  \nATOM   2246  CD  PRO A 284       2.259 -14.270 -11.530  1.00 94.19           C  \nATOM   2247  N   GLY A 285      -0.136 -10.906 -13.825  1.00 95.18           N  \nATOM   2248  CA  GLY A 285      -1.443 -10.429 -14.280  1.00 95.18           C  \nATOM   2249  C   GLY A 285      -2.371  -9.947 -13.163  1.00 95.18           C  \nATOM   2250  O   GLY A 285      -3.550  -9.736 -13.418  1.00 95.18           O  \nATOM   2251  N   GLN A 286      -1.867  -9.813 -11.932  1.00 94.36           N  \nATOM   2252  CA  GLN A 286      -2.654  -9.382 -10.775  1.00 94.36           C  \nATOM   2253  C   GLN A 286      -1.982  -8.241 -10.022  1.00 94.36           C  \nATOM   2254  CB  GLN A 286      -2.886 -10.540  -9.797  1.00 94.36           C  \nATOM   2255  O   GLN A 286      -0.753  -8.176  -9.961  1.00 94.36           O  \nATOM   2256  CG  GLN A 286      -3.666 -11.711 -10.399  1.00 94.36           C  \nATOM   2257  CD  GLN A 286      -3.872 -12.832  -9.386  1.00 94.36           C  \nATOM   2258  NE2 GLN A 286      -4.129 -14.037  -9.841  1.00 94.36           N  \nATOM   2259  OE1 GLN A 286      -3.775 -12.669  -8.178  1.00 94.36           O  \nATOM   2260  N   GLN A 287      -2.763  -7.426  -9.317  1.00 94.94           N  \nATOM   2261  CA  GLN A 287      -2.246  -6.348  -8.465  1.00 94.94           C  \nATOM   2262  C   GLN A 287      -1.394  -5.330  -9.248  1.00 94.94           C  \nATOM   2263  CB  GLN A 287      -1.528  -6.916  -7.219  1.00 94.94           C  \nATOM   2264  O   GLN A 287      -0.367  -4.849  -8.753  1.00 94.94           O  \nATOM   2265  CG  GLN A 287      -2.417  -7.828  -6.361  1.00 94.94           C  \nATOM   2266  CD  GLN A 287      -3.572  -7.083  -5.702  1.00 94.94           C  \nATOM   2267  NE2 GLN A 287      -4.671  -7.746  -5.423  1.00 94.94           N  \nATOM   2268  OE1 GLN A 287      -3.498  -5.907  -5.395  1.00 94.94           O  \nATOM   2269  N   LEU A 288      -1.768  -5.044 -10.501  1.00 97.51           N  \nATOM   2270  CA  LEU A 288      -0.963  -4.210 -11.396  1.00 97.51           C  \nATOM   2271  C   LEU A 288      -0.801  -2.780 -10.869  1.00 97.51           C  \nATOM   2272  CB  LEU A 288      -1.572  -4.229 -12.807  1.00 97.51           C  \nATOM   2273  O   LEU A 288       0.307  -2.244 -10.882  1.00 97.51           O  \nATOM   2274  CG  LEU A 288      -1.497  -5.599 -13.511  1.00 97.51           C  \nATOM   2275  CD1 LEU A 288      -2.082  -5.485 -14.914  1.00 97.51           C  \nATOM   2276  CD2 LEU A 288      -0.063  -6.107 -13.663  1.00 97.51           C  \nATOM   2277  N   TYR A 289      -1.856  -2.175 -10.326  1.00 98.38           N  \nATOM   2278  CA  TYR A 289      -1.767  -0.839  -9.740  1.00 98.38           C  \nATOM   2279  C   TYR A 289      -0.888  -0.800  -8.485  1.00 98.38           C  \nATOM   2280  CB  TYR A 289      -3.175  -0.343  -9.444  1.00 98.38           C  \nATOM   2281  O   TYR A 289      -0.071   0.112  -8.328  1.00 98.38           O  \nATOM   2282  CG  TYR A 289      -3.264   1.107  -9.069  1.00 98.38           C  \nATOM   2283  CD1 TYR A 289      -3.743   1.468  -7.800  1.00 98.38           C  \nATOM   2284  CD2 TYR A 289      -2.959   2.084 -10.035  1.00 98.38           C  \nATOM   2285  CE1 TYR A 289      -3.944   2.820  -7.496  1.00 98.38           C  \nATOM   2286  CE2 TYR A 289      -3.178   3.439  -9.747  1.00 98.38           C  \nATOM   2287  OH  TYR A 289      -3.919   5.077  -8.179  1.00 98.38           O  \nATOM   2288  CZ  TYR A 289      -3.677   3.791  -8.478  1.00 98.38           C  \nATOM   2289  N   GLU A 290      -0.971  -1.824  -7.626  1.00 97.42           N  \nATOM   2290  CA  GLU A 290      -0.045  -1.967  -6.497  1.00 97.42           C  \nATOM   2291  C   GLU A 290       1.408  -2.078  -6.986  1.00 97.42           C  \nATOM   2292  CB  GLU A 290      -0.430  -3.165  -5.603  1.00 97.42           C  \nATOM   2293  O   GLU A 290       2.296  -1.465  -6.394  1.00 97.42           O  \nATOM   2294  CG  GLU A 290       0.555  -3.313  -4.433  1.00 97.42           C  \nATOM   2295  CD  GLU A 290       0.189  -4.395  -3.404  1.00 97.42           C  \nATOM   2296  OE1 GLU A 290       0.736  -5.522  -3.515  1.00 97.42           O  \nATOM   2297  OE2 GLU A 290      -0.456  -4.029  -2.394  1.00 97.42           O  \nATOM   2298  N   LYS A 291       1.670  -2.795  -8.085  1.00 97.14           N  \nATOM   2299  CA  LYS A 291       3.019  -2.950  -8.659  1.00 97.14           C  \nATOM   2300  C   LYS A 291       3.625  -1.650  -9.183  1.00 97.14           C  \nATOM   2301  CB  LYS A 291       3.004  -4.040  -9.738  1.00 97.14           C  \nATOM   2302  O   LYS A 291       4.843  -1.489  -9.128  1.00 97.14           O  \nATOM   2303  CG  LYS A 291       2.933  -5.432  -9.101  1.00 97.14           C  \nATOM   2304  CD  LYS A 291       2.498  -6.484 -10.118  1.00 97.14           C  \nATOM   2305  CE  LYS A 291       2.535  -7.857  -9.451  1.00 97.14           C  \nATOM   2306  NZ  LYS A 291       1.838  -8.853 -10.278  1.00 97.14           N  \nATOM   2307  N   LEU A 292       2.798  -0.702  -9.618  1.00 98.11           N  \nATOM   2308  CA  LEU A 292       3.253   0.615 -10.076  1.00 98.11           C  \nATOM   2309  C   LEU A 292       3.658   1.559  -8.933  1.00 98.11           C  \nATOM   2310  CB  LEU A 292       2.140   1.260 -10.918  1.00 98.11           C  \nATOM   2311  O   LEU A 292       4.398   2.515  -9.172  1.00 98.11           O  \nATOM   2312  CG  LEU A 292       1.820   0.529 -12.233  1.00 98.11           C  \nATOM   2313  CD1 LEU A 292       0.645   1.226 -12.910  1.00 98.11           C  \nATOM   2314  CD2 LEU A 292       3.003   0.535 -13.194  1.00 98.11           C  \nATOM   2315  N   ILE A 293       3.155   1.328  -7.715  1.00 98.28           N  \nATOM   2316  CA  ILE A 293       3.244   2.282  -6.595  1.00 98.28           C  \nATOM   2317  C   ILE A 293       4.026   1.709  -5.410  1.00 98.28           C  \nATOM   2318  CB  ILE A 293       1.820   2.713  -6.161  1.00 98.28           C  \nATOM   2319  O   ILE A 293       4.834   2.402  -4.788  1.00 98.28           O  \nATOM   2320  CG1 ILE A 293       1.051   3.387  -7.323  1.00 98.28           C  \nATOM   2321  CG2 ILE A 293       1.889   3.676  -4.955  1.00 98.28           C  \nATOM   2322  CD1 ILE A 293      -0.457   3.490  -7.073  1.00 98.28           C  \nATOM   2323  N   GLY A 294       3.755   0.450  -5.073  1.00 95.52           N  \nATOM   2324  CA  GLY A 294       4.204  -0.208  -3.858  1.00 95.52           C  \nATOM   2325  C   GLY A 294       5.722  -0.292  -3.757  1.00 95.52           C  \nATOM   2326  O   GLY A 294       6.438  -0.655  -4.695  1.00 95.52           O  \nATOM   2327  N   GLY A 295       6.225  -0.031  -2.556  1.00 95.57           N  \nATOM   2328  CA  GLY A 295       7.639  -0.114  -2.221  1.00 95.57           C  \nATOM   2329  C   GLY A 295       8.224  -1.517  -2.371  1.00 95.57           C  \nATOM   2330  O   GLY A 295       9.442  -1.649  -2.400  1.00 95.57           O  \nATOM   2331  N   LYS A 296       7.410  -2.568  -2.519  1.00 93.42           N  \nATOM   2332  CA  LYS A 296       7.898  -3.898  -2.906  1.00 93.42           C  \nATOM   2333  C   LYS A 296       8.521  -3.922  -4.308  1.00 93.42           C  \nATOM   2334  CB  LYS A 296       6.737  -4.896  -2.795  1.00 93.42           C  \nATOM   2335  O   LYS A 296       9.429  -4.712  -4.548  1.00 93.42           O  \nATOM   2336  CG  LYS A 296       7.193  -6.312  -3.152  1.00 93.42           C  \nATOM   2337  CD  LYS A 296       6.186  -7.380  -2.732  1.00 93.42           C  \nATOM   2338  CE  LYS A 296       6.840  -8.716  -3.083  1.00 93.42           C  \nATOM   2339  NZ  LYS A 296       6.147  -9.857  -2.458  1.00 93.42           N  \nATOM   2340  N   TYR A 297       8.043  -3.073  -5.215  1.00 96.72           N  \nATOM   2341  CA  TYR A 297       8.346  -3.151  -6.647  1.00 96.72           C  \nATOM   2342  C   TYR A 297       9.165  -1.961  -7.158  1.00 96.72           C  \nATOM   2343  CB  TYR A 297       7.017  -3.272  -7.396  1.00 96.72           C  \nATOM   2344  O   TYR A 297       9.899  -2.095  -8.133  1.00 96.72           O  \nATOM   2345  CG  TYR A 297       6.135  -4.409  -6.905  1.00 96.72           C  \nATOM   2346  CD1 TYR A 297       6.422  -5.743  -7.255  1.00 96.72           C  \nATOM   2347  CD2 TYR A 297       5.030  -4.125  -6.078  1.00 96.72           C  \nATOM   2348  CE1 TYR A 297       5.582  -6.786  -6.813  1.00 96.72           C  \nATOM   2349  CE2 TYR A 297       4.173  -5.158  -5.661  1.00 96.72           C  \nATOM   2350  OH  TYR A 297       3.609  -7.479  -5.622  1.00 96.72           O  \nATOM   2351  CZ  TYR A 297       4.443  -6.489  -6.032  1.00 96.72           C  \nATOM   2352  N   MET A 298       9.103  -0.817  -6.469  1.00 98.22           N  \nATOM   2353  CA  MET A 298       9.765   0.429  -6.876  1.00 98.22           C  \nATOM   2354  C   MET A 298      11.270   0.276  -7.151  1.00 98.22           C  \nATOM   2355  CB  MET A 298       9.504   1.475  -5.786  1.00 98.22           C  \nATOM   2356  O   MET A 298      11.760   0.751  -8.174  1.00 98.22           O  \nATOM   2357  CG  MET A 298       9.989   2.872  -6.184  1.00 98.22           C  \nATOM   2358  SD  MET A 298       9.701   4.144  -4.925  1.00 98.22           S  \nATOM   2359  CE  MET A 298       7.887   4.211  -4.938  1.00 98.22           C  \nATOM   2360  N   GLY A 299      12.009  -0.406  -6.272  1.00 98.36           N  \nATOM   2361  CA  GLY A 299      13.436  -0.659  -6.481  1.00 98.36           C  \nATOM   2362  C   GLY A 299      13.728  -1.521  -7.716  1.00 98.36           C  \nATOM   2363  O   GLY A 299      14.647  -1.219  -8.477  1.00 98.36           O  \nATOM   2364  N   GLU A 300      12.901  -2.537  -7.974  1.00 98.34           N  \nATOM   2365  CA  GLU A 300      13.043  -3.397  -9.153  1.00 98.34           C  \nATOM   2366  C   GLU A 300      12.731  -2.641 -10.450  1.00 98.34           C  \nATOM   2367  CB  GLU A 300      12.157  -4.643  -8.992  1.00 98.34           C  \nATOM   2368  O   GLU A 300      13.454  -2.800 -11.432  1.00 98.34           O  \nATOM   2369  CG  GLU A 300      12.235  -5.614 -10.179  1.00 98.34           C  \nATOM   2370  CD  GLU A 300      13.619  -6.212 -10.433  1.00 98.34           C  \nATOM   2371  OE1 GLU A 300      13.808  -6.854 -11.486  1.00 98.34           O  \nATOM   2372  OE2 GLU A 300      14.535  -6.108  -9.586  1.00 98.34           O  \nATOM   2373  N   LEU A 301      11.724  -1.761 -10.443  1.00 98.71           N  \nATOM   2374  CA  LEU A 301      11.445  -0.869 -11.571  1.00 98.71           C  \nATOM   2375  C   LEU A 301      12.659   0.005 -11.895  1.00 98.71           C  \nATOM   2376  CB  LEU A 301      10.222   0.009 -11.256  1.00 98.71           C  \nATOM   2377  O   LEU A 301      13.086   0.059 -13.047  1.00 98.71           O  \nATOM   2378  CG  LEU A 301       8.881  -0.739 -11.284  1.00 98.71           C  \nATOM   2379  CD1 LEU A 301       7.787   0.165 -10.718  1.00 98.71           C  \nATOM   2380  CD2 LEU A 301       8.504  -1.137 -12.710  1.00 98.71           C  \nATOM   2381  N   VAL A 302      13.272   0.626 -10.880  1.00 98.81           N  \nATOM   2382  CA  VAL A 302      14.509   1.396 -11.075  1.00 98.81           C  \nATOM   2383  C   VAL A 302      15.614   0.504 -11.632  1.00 98.81           C  \nATOM   2384  CB  VAL A 302      14.957   2.105  -9.782  1.00 98.81           C  \nATOM   2385  O   VAL A 302      16.250   0.881 -12.611  1.00 98.81           O  \nATOM   2386  CG1 VAL A 302      16.337   2.761  -9.930  1.00 98.81           C  \nATOM   2387  CG2 VAL A 302      13.962   3.215  -9.421  1.00 98.81           C  \nATOM   2388  N   ARG A 303      15.823  -0.697 -11.078  1.00 98.70           N  \nATOM   2389  CA  ARG A 303      16.848  -1.638 -11.558  1.00 98.70           C  \nATOM   2390  C   ARG A 303      16.712  -1.927 -13.052  1.00 98.70           C  \nATOM   2391  CB  ARG A 303      16.740  -2.956 -10.784  1.00 98.70           C  \nATOM   2392  O   ARG A 303      17.713  -1.900 -13.764  1.00 98.70           O  \nATOM   2393  CG  ARG A 303      18.019  -3.794 -10.913  1.00 98.70           C  \nATOM   2394  CD  ARG A 303      17.806  -5.187 -10.317  1.00 98.70           C  \nATOM   2395  NE  ARG A 303      16.832  -5.958 -11.106  1.00 98.70           N  \nATOM   2396  NH1 ARG A 303      18.259  -6.743 -12.698  1.00 98.70           N  \nATOM   2397  NH2 ARG A 303      16.087  -7.198 -12.854  1.00 98.70           N  \nATOM   2398  CZ  ARG A 303      17.059  -6.619 -12.219  1.00 98.70           C  \nATOM   2399  N   LEU A 304      15.493  -2.193 -13.520  1.00 98.78           N  \nATOM   2400  CA  LEU A 304      15.219  -2.487 -14.926  1.00 98.78           C  \nATOM   2401  C   LEU A 304      15.481  -1.271 -15.825  1.00 98.78           C  \nATOM   2402  CB  LEU A 304      13.774  -2.985 -15.068  1.00 98.78           C  \nATOM   2403  O   LEU A 304      16.093  -1.425 -16.879  1.00 98.78           O  \nATOM   2404  CG  LEU A 304      13.496  -4.354 -14.425  1.00 98.78           C  \nATOM   2405  CD1 LEU A 304      11.992  -4.592 -14.431  1.00 98.78           C  \nATOM   2406  CD2 LEU A 304      14.170  -5.495 -15.191  1.00 98.78           C  \nATOM   2407  N   VAL A 305      15.125  -0.061 -15.378  1.00 98.70           N  \nATOM   2408  CA  VAL A 305      15.486   1.186 -16.079  1.00 98.70           C  \nATOM   2409  C   VAL A 305      17.005   1.345 -16.160  1.00 98.70           C  \nATOM   2410  CB  VAL A 305      14.853   2.414 -15.397  1.00 98.70           C  \nATOM   2411  O   VAL A 305      17.538   1.677 -17.217  1.00 98.70           O  \nATOM   2412  CG1 VAL A 305      15.287   3.738 -16.041  1.00 98.70           C  \nATOM   2413  CG2 VAL A 305      13.329   2.360 -15.487  1.00 98.70           C  \nATOM   2414  N   LEU A 306      17.735   1.066 -15.074  1.00 98.72           N  \nATOM   2415  CA  LEU A 306      19.199   1.127 -15.086  1.00 98.72           C  \nATOM   2416  C   LEU A 306      19.797   0.117 -16.071  1.00 98.72           C  \nATOM   2417  CB  LEU A 306      19.786   0.923 -13.677  1.00 98.72           C  \nATOM   2418  O   LEU A 306      20.716   0.477 -16.802  1.00 98.72           O  \nATOM   2419  CG  LEU A 306      19.394   1.964 -12.612  1.00 98.72           C  \nATOM   2420  CD1 LEU A 306      20.190   1.705 -11.332  1.00 98.72           C  \nATOM   2421  CD2 LEU A 306      19.605   3.410 -13.055  1.00 98.72           C  \nATOM   2422  N   LEU A 307      19.273  -1.112 -16.134  1.00 98.55           N  \nATOM   2423  CA  LEU A 307      19.714  -2.104 -17.119  1.00 98.55           C  \nATOM   2424  C   LEU A 307      19.454  -1.641 -18.554  1.00 98.55           C  \nATOM   2425  CB  LEU A 307      19.044  -3.464 -16.871  1.00 98.55           C  \nATOM   2426  O   LEU A 307      20.363  -1.707 -19.376  1.00 98.55           O  \nATOM   2427  CG  LEU A 307      19.543  -4.239 -15.641  1.00 98.55           C  \nATOM   2428  CD1 LEU A 307      18.869  -5.612 -15.646  1.00 98.55           C  \nATOM   2429  CD2 LEU A 307      21.059  -4.461 -15.631  1.00 98.55           C  \nATOM   2430  N   ARG A 308      18.277  -1.074 -18.838  1.00 98.34           N  \nATOM   2431  CA  ARG A 308      17.972  -0.504 -20.157  1.00 98.34           C  \nATOM   2432  C   ARG A 308      18.960   0.594 -20.550  1.00 98.34           C  \nATOM   2433  CB  ARG A 308      16.529   0.018 -20.136  1.00 98.34           C  \nATOM   2434  O   ARG A 308      19.440   0.623 -21.681  1.00 98.34           O  \nATOM   2435  CG  ARG A 308      16.047   0.578 -21.479  1.00 98.34           C  \nATOM   2436  CD  ARG A 308      15.855  -0.542 -22.501  1.00 98.34           C  \nATOM   2437  NE  ARG A 308      15.251  -0.015 -23.732  1.00 98.34           N  \nATOM   2438  NH1 ARG A 308      16.741  -0.899 -25.219  1.00 98.34           N  \nATOM   2439  NH2 ARG A 308      15.385   0.701 -25.894  1.00 98.34           N  \nATOM   2440  CZ  ARG A 308      15.770  -0.087 -24.936  1.00 98.34           C  \nATOM   2441  N   LEU A 309      19.299   1.483 -19.616  1.00 98.53           N  \nATOM   2442  CA  LEU A 309      20.278   2.548 -19.845  1.00 98.53           C  \nATOM   2443  C   LEU A 309      21.697   2.003 -20.062  1.00 98.53           C  \nATOM   2444  CB  LEU A 309      20.249   3.527 -18.661  1.00 98.53           C  \nATOM   2445  O   LEU A 309      22.455   2.577 -20.845  1.00 98.53           O  \nATOM   2446  CG  LEU A 309      18.951   4.346 -18.532  1.00 98.53           C  \nATOM   2447  CD1 LEU A 309      18.957   5.083 -17.194  1.00 98.53           C  \nATOM   2448  CD2 LEU A 309      18.828   5.380 -19.650  1.00 98.53           C  \nATOM   2449  N   VAL A 310      22.067   0.906 -19.399  1.00 98.14           N  \nATOM   2450  CA  VAL A 310      23.329   0.199 -19.656  1.00 98.14           C  \nATOM   2451  C   VAL A 310      23.323  -0.403 -21.061  1.00 98.14           C  \nATOM   2452  CB  VAL A 310      23.591  -0.873 -18.584  1.00 98.14           C  \nATOM   2453  O   VAL A 310      24.246  -0.136 -21.825  1.00 98.14           O  \nATOM   2454  CG1 VAL A 310      24.771  -1.775 -18.942  1.00 98.14           C  \nATOM   2455  CG2 VAL A 310      23.937  -0.232 -17.232  1.00 98.14           C  \nATOM   2456  N   ASP A 311      22.278  -1.139 -21.438  1.00 97.49           N  \nATOM   2457  CA  ASP A 311      22.187  -1.809 -22.744  1.00 97.49           C  \nATOM   2458  C   ASP A 311      22.213  -0.811 -23.917  1.00 97.49           C  \nATOM   2459  CB  ASP A 311      20.910  -2.667 -22.787  1.00 97.49           C  \nATOM   2460  O   ASP A 311      22.756  -1.094 -24.984  1.00 97.49           O  \nATOM   2461  CG  ASP A 311      20.930  -3.879 -21.842  1.00 97.49           C  \nATOM   2462  OD1 ASP A 311      22.031  -4.302 -21.414  1.00 97.49           O  \nATOM   2463  OD2 ASP A 311      19.826  -4.410 -21.587  1.00 97.49           O  \nATOM   2464  N   GLU A 312      21.702   0.405 -23.705  1.00 96.99           N  \nATOM   2465  CA  GLU A 312      21.763   1.519 -24.663  1.00 96.99           C  \nATOM   2466  C   GLU A 312      23.104   2.292 -24.641  1.00 96.99           C  \nATOM   2467  CB  GLU A 312      20.552   2.440 -24.424  1.00 96.99           C  \nATOM   2468  O   GLU A 312      23.244   3.314 -25.322  1.00 96.99           O  \nATOM   2469  CG  GLU A 312      19.209   1.790 -24.820  1.00 96.99           C  \nATOM   2470  CD  GLU A 312      19.022   1.608 -26.337  1.00 96.99           C  \nATOM   2471  OE1 GLU A 312      18.115   0.847 -26.747  1.00 96.99           O  \nATOM   2472  OE2 GLU A 312      19.724   2.291 -27.120  1.00 96.99           O  \nATOM   2473  N   ASN A 313      24.096   1.816 -23.875  1.00 96.35           N  \nATOM   2474  CA  ASN A 313      25.411   2.430 -23.642  1.00 96.35           C  \nATOM   2475  C   ASN A 313      25.336   3.868 -23.079  1.00 96.35           C  \nATOM   2476  CB  ASN A 313      26.283   2.264 -24.898  1.00 96.35           C  \nATOM   2477  O   ASN A 313      26.169   4.735 -23.363  1.00 96.35           O  \nATOM   2478  CG  ASN A 313      27.757   2.531 -24.648  1.00 96.35           C  \nATOM   2479  ND2 ASN A 313      28.493   2.884 -25.676  1.00 96.35           N  \nATOM   2480  OD1 ASN A 313      28.288   2.416 -23.558  1.00 96.35           O  \nATOM   2481  N   LEU A 314      24.309   4.138 -22.270  1.00 97.14           N  \nATOM   2482  CA  LEU A 314      24.054   5.426 -21.618  1.00 97.14           C  \nATOM   2483  C   LEU A 314      24.451   5.429 -20.140  1.00 97.14           C  \nATOM   2484  CB  LEU A 314      22.571   5.801 -21.764  1.00 97.14           C  \nATOM   2485  O   LEU A 314      24.515   6.492 -19.525  1.00 97.14           O  \nATOM   2486  CG  LEU A 314      22.081   5.917 -23.213  1.00 97.14           C  \nATOM   2487  CD1 LEU A 314      20.569   6.102 -23.224  1.00 97.14           C  \nATOM   2488  CD2 LEU A 314      22.740   7.092 -23.938  1.00 97.14           C  \nATOM   2489  N   LEU A 315      24.764   4.279 -19.556  1.00 97.24           N  \nATOM   2490  CA  LEU A 315      25.126   4.177 -18.148  1.00 97.24           C  \nATOM   2491  C   LEU A 315      26.269   3.179 -17.958  1.00 97.24           C  \nATOM   2492  CB  LEU A 315      23.848   3.809 -17.377  1.00 97.24           C  \nATOM   2493  O   LEU A 315      26.328   2.168 -18.654  1.00 97.24           O  \nATOM   2494  CG  LEU A 315      23.966   3.931 -15.856  1.00 97.24           C  \nATOM   2495  CD1 LEU A 315      24.131   5.377 -15.392  1.00 97.24           C  \nATOM   2496  CD2 LEU A 315      22.707   3.368 -15.203  1.00 97.24           C  \nATOM   2497  N   PHE A 316      27.201   3.494 -17.053  1.00 96.73           N  \nATOM   2498  CA  PHE A 316      28.316   2.614 -16.661  1.00 96.73           C  \nATOM   2499  C   PHE A 316      29.141   2.072 -17.842  1.00 96.73           C  \nATOM   2500  CB  PHE A 316      27.819   1.491 -15.731  1.00 96.73           C  \nATOM   2501  O   PHE A 316      29.593   0.933 -17.824  1.00 96.73           O  \nATOM   2502  CG  PHE A 316      26.925   1.931 -14.588  1.00 96.73           C  \nATOM   2503  CD1 PHE A 316      27.260   3.053 -13.805  1.00 96.73           C  \nATOM   2504  CD2 PHE A 316      25.735   1.227 -14.325  1.00 96.73           C  \nATOM   2505  CE1 PHE A 316      26.384   3.488 -12.796  1.00 96.73           C  \nATOM   2506  CE2 PHE A 316      24.856   1.671 -13.323  1.00 96.73           C  \nATOM   2507  CZ  PHE A 316      25.177   2.810 -12.567  1.00 96.73           C  \nATOM   2508  N   HIS A 317      29.327   2.885 -18.888  1.00 93.79           N  \nATOM   2509  CA  HIS A 317      30.048   2.502 -20.113  1.00 93.79           C  \nATOM   2510  C   HIS A 317      29.492   1.252 -20.822  1.00 93.79           C  \nATOM   2511  CB  HIS A 317      31.557   2.401 -19.824  1.00 93.79           C  \nATOM   2512  O   HIS A 317      30.238   0.553 -21.503  1.00 93.79           O  \nATOM   2513  CG  HIS A 317      32.133   3.653 -19.224  1.00 93.79           C  \nATOM   2514  CD2 HIS A 317      32.505   3.853 -17.922  1.00 93.79           C  \nATOM   2515  ND1 HIS A 317      32.372   4.822 -19.904  1.00 93.79           N  \nATOM   2516  CE1 HIS A 317      32.881   5.708 -19.035  1.00 93.79           C  \nATOM   2517  NE2 HIS A 317      32.988   5.166 -17.814  1.00 93.79           N  \nATOM   2518  N   GLY A 318      28.196   0.972 -20.660  1.00 95.50           N  \nATOM   2519  CA  GLY A 318      27.554  -0.188 -21.273  1.00 95.50           C  \nATOM   2520  C   GLY A 318      27.805  -1.506 -20.540  1.00 95.50           C  \nATOM   2521  O   GLY A 318      27.440  -2.565 -21.043  1.00 95.50           O  \nATOM   2522  N   GLU A 319      28.394  -1.462 -19.341  1.00 95.89           N  \nATOM   2523  CA  GLU A 319      28.722  -2.649 -18.554  1.00 95.89           C  \nATOM   2524  C   GLU A 319      28.010  -2.636 -17.192  1.00 95.89           C  \nATOM   2525  CB  GLU A 319      30.246  -2.777 -18.400  1.00 95.89           C  \nATOM   2526  O   GLU A 319      28.374  -1.909 -16.268  1.00 95.89           O  \nATOM   2527  CG  GLU A 319      30.957  -3.041 -19.741  1.00 95.89           C  \nATOM   2528  CD  GLU A 319      32.474  -3.271 -19.600  1.00 95.89           C  \nATOM   2529  OE1 GLU A 319      33.126  -3.494 -20.647  1.00 95.89           O  \nATOM   2530  OE2 GLU A 319      32.993  -3.250 -18.458  1.00 95.89           O  \nATOM   2531  N   ALA A 320      26.994  -3.489 -17.039  1.00 95.63           N  \nATOM   2532  CA  ALA A 320      26.408  -3.780 -15.733  1.00 95.63           C  \nATOM   2533  C   ALA A 320      27.305  -4.745 -14.940  1.00 95.63           C  \nATOM   2534  CB  ALA A 320      24.980  -4.325 -15.887  1.00 95.63           C  \nATOM   2535  O   ALA A 320      27.967  -5.618 -15.510  1.00 95.63           O  \nATOM   2536  N   SER A 321      27.271  -4.629 -13.615  1.00 96.81           N  \nATOM   2537  CA  SER A 321      27.836  -5.621 -12.700  1.00 96.81           C  \nATOM   2538  C   SER A 321      26.909  -6.832 -12.547  1.00 96.81           C  \nATOM   2539  CB  SER A 321      28.071  -4.974 -11.337  1.00 96.81           C  \nATOM   2540  O   SER A 321      25.699  -6.742 -12.767  1.00 96.81           O  \nATOM   2541  OG  SER A 321      26.828  -4.565 -10.802  1.00 96.81           O  \nATOM   2542  N   GLU A 322      27.456  -7.960 -12.092  1.00 96.83           N  \nATOM   2543  CA  GLU A 322      26.658  -9.156 -11.780  1.00 96.83           C  \nATOM   2544  C   GLU A 322      25.626  -8.890 -10.672  1.00 96.83           C  \nATOM   2545  CB  GLU A 322      27.597 -10.309 -11.380  1.00 96.83           C  \nATOM   2546  O   GLU A 322      24.499  -9.388 -10.716  1.00 96.83           O  \nATOM   2547  CG  GLU A 322      28.507 -10.764 -12.533  1.00 96.83           C  \nATOM   2548  CD  GLU A 322      27.678 -11.120 -13.774  1.00 96.83           C  \nATOM   2549  OE1 GLU A 322      27.706 -10.327 -14.747  1.00 96.83           O  \nATOM   2550  OE2 GLU A 322      26.942 -12.124 -13.706  1.00 96.83           O  \nATOM   2551  N   GLN A 323      25.966  -8.029  -9.709  1.00 97.05           N  \nATOM   2552  CA  GLN A 323      25.046  -7.605  -8.657  1.00 97.05           C  \nATOM   2553  C   GLN A 323      23.870  -6.806  -9.231  1.00 97.05           C  \nATOM   2554  CB  GLN A 323      25.773  -6.777  -7.587  1.00 97.05           C  \nATOM   2555  O   GLN A 323      22.733  -7.102  -8.886  1.00 97.05           O  \nATOM   2556  CG  GLN A 323      26.843  -7.539  -6.787  1.00 97.05           C  \nATOM   2557  CD  GLN A 323      28.213  -7.650  -7.458  1.00 97.05           C  \nATOM   2558  NE2 GLN A 323      29.206  -8.132  -6.746  1.00 97.05           N  \nATOM   2559  OE1 GLN A 323      28.439  -7.316  -8.611  1.00 97.05           O  \nATOM   2560  N   LEU A 324      24.099  -5.847 -10.140  1.00 97.70           N  \nATOM   2561  CA  LEU A 324      23.008  -5.074 -10.752  1.00 97.70           C  \nATOM   2562  C   LEU A 324      22.108  -5.951 -11.645  1.00 97.70           C  \nATOM   2563  CB  LEU A 324      23.600  -3.885 -11.535  1.00 97.70           C  \nATOM   2564  O   LEU A 324      20.893  -5.740 -11.710  1.00 97.70           O  \nATOM   2565  CG  LEU A 324      22.538  -2.964 -12.173  1.00 97.70           C  \nATOM   2566  CD1 LEU A 324      21.685  -2.252 -11.120  1.00 97.70           C  \nATOM   2567  CD2 LEU A 324      23.201  -1.899 -13.046  1.00 97.70           C  \nATOM   2568  N   ARG A 325      22.685  -6.962 -12.309  1.00 97.47           N  \nATOM   2569  CA  ARG A 325      21.923  -7.949 -13.095  1.00 97.47           C  \nATOM   2570  C   ARG A 325      21.019  -8.827 -12.232  1.00 97.47           C  \nATOM   2571  CB  ARG A 325      22.873  -8.830 -13.920  1.00 97.47           C  \nATOM   2572  O   ARG A 325      20.005  -9.314 -12.731  1.00 97.47           O  \nATOM   2573  CG  ARG A 325      23.494  -8.067 -15.094  1.00 97.47           C  \nATOM   2574  CD  ARG A 325      24.284  -9.023 -15.994  1.00 97.47           C  \nATOM   2575  NE  ARG A 325      24.871  -8.296 -17.133  1.00 97.47           N  \nATOM   2576  NH1 ARG A 325      27.025  -8.113 -16.318  1.00 97.47           N  \nATOM   2577  NH2 ARG A 325      26.423  -6.957 -18.112  1.00 97.47           N  \nATOM   2578  CZ  ARG A 325      26.097  -7.808 -17.179  1.00 97.47           C  \nATOM   2579  N   THR A 326      21.343  -8.998 -10.953  1.00 97.57           N  \nATOM   2580  CA  THR A 326      20.552  -9.812 -10.028  1.00 97.57           C  \nATOM   2581  C   THR A 326      19.220  -9.128  -9.710  1.00 97.57           C  \nATOM   2582  CB  THR A 326      21.353 -10.127  -8.757  1.00 97.57           C  \nATOM   2583  O   THR A 326      19.175  -7.986  -9.251  1.00 97.57           O  \nATOM   2584  CG2 THR A 326      20.591 -11.056  -7.812  1.00 97.57           C  \nATOM   2585  OG1 THR A 326      22.546 -10.803  -9.099  1.00 97.57           O  \nATOM   2586  N   ARG A 327      18.110  -9.830  -9.957  1.00 96.12           N  \nATOM   2587  CA  ARG A 327      16.754  -9.351  -9.657  1.00 96.12           C  \nATOM   2588  C   ARG A 327      16.603  -8.997  -8.176  1.00 96.12           C  \nATOM   2589  CB  ARG A 327      15.743 -10.416 -10.093  1.00 96.12           C  \nATOM   2590  O   ARG A 327      17.056  -9.747  -7.318  1.00 96.12           O  \nATOM   2591  CG  ARG A 327      14.312  -9.953  -9.823  1.00 96.12           C  \nATOM   2592  CD  ARG A 327      13.318 -10.949 -10.393  1.00 96.12           C  \nATOM   2593  NE  ARG A 327      11.955 -10.493 -10.112  1.00 96.12           N  \nATOM   2594  NH1 ARG A 327      10.994 -12.557  -9.903  1.00 96.12           N  \nATOM   2595  NH2 ARG A 327       9.753 -10.723  -9.661  1.00 96.12           N  \nATOM   2596  CZ  ARG A 327      10.914 -11.256  -9.884  1.00 96.12           C  \nATOM   2597  N   GLY A 328      15.954  -7.871  -7.885  1.00 94.61           N  \nATOM   2598  CA  GLY A 328      15.738  -7.391  -6.520  1.00 94.61           C  \nATOM   2599  C   GLY A 328      16.977  -6.800  -5.839  1.00 94.61           C  \nATOM   2600  O   GLY A 328      16.873  -6.358  -4.700  1.00 94.61           O  \nATOM   2601  N   ALA A 329      18.137  -6.745  -6.509  1.00 96.69           N  \nATOM   2602  CA  ALA A 329      19.364  -6.212  -5.910  1.00 96.69           C  \nATOM   2603  C   ALA A 329      19.336  -4.690  -5.693  1.00 96.69           C  \nATOM   2604  CB  ALA A 329      20.546  -6.606  -6.795  1.00 96.69           C  \nATOM   2605  O   ALA A 329      20.056  -4.180  -4.836  1.00 96.69           O  \nATOM   2606  N   PHE A 330      18.517  -3.954  -6.453  1.00 98.18           N  \nATOM   2607  CA  PHE A 330      18.291  -2.531  -6.214  1.00 98.18           C  \nATOM   2608  C   PHE A 330      17.053  -2.358  -5.333  1.00 98.18           C  \nATOM   2609  CB  PHE A 330      18.209  -1.752  -7.530  1.00 98.18           C  \nATOM   2610  O   PHE A 330      15.921  -2.365  -5.803  1.00 98.18           O  \nATOM   2611  CG  PHE A 330      18.499  -0.275  -7.364  1.00 98.18           C  \nATOM   2612  CD1 PHE A 330      17.498   0.602  -6.905  1.00 98.18           C  \nATOM   2613  CD2 PHE A 330      19.783   0.223  -7.653  1.00 98.18           C  \nATOM   2614  CE1 PHE A 330      17.788   1.967  -6.733  1.00 98.18           C  \nATOM   2615  CE2 PHE A 330      20.071   1.588  -7.482  1.00 98.18           C  \nATOM   2616  CZ  PHE A 330      19.070   2.462  -7.024  1.00 98.18           C  \nATOM   2617  N   GLU A 331      17.263  -2.250  -4.027  1.00 96.58           N  \nATOM   2618  CA  GLU A 331      16.176  -2.151  -3.056  1.00 96.58           C  \nATOM   2619  C   GLU A 331      15.514  -0.764  -3.060  1.00 96.58           C  \nATOM   2620  CB  GLU A 331      16.723  -2.457  -1.661  1.00 96.58           C  \nATOM   2621  O   GLU A 331      16.160   0.258  -3.286  1.00 96.58           O  \nATOM   2622  CG  GLU A 331      17.264  -3.885  -1.498  1.00 96.58           C  \nATOM   2623  CD  GLU A 331      17.944  -4.008  -0.133  1.00 96.58           C  \nATOM   2624  OE1 GLU A 331      19.180  -4.192  -0.077  1.00 96.58           O  \nATOM   2625  OE2 GLU A 331      17.285  -3.723   0.892  1.00 96.58           O  \nATOM   2626  N   THR A 332      14.236  -0.688  -2.688  1.00 97.31           N  \nATOM   2627  CA  THR A 332      13.499   0.588  -2.594  1.00 97.31           C  \nATOM   2628  C   THR A 332      14.137   1.589  -1.627  1.00 97.31           C  \nATOM   2629  CB  THR A 332      12.048   0.305  -2.207  1.00 97.31           C  \nATOM   2630  O   THR A 332      14.095   2.793  -1.866  1.00 97.31           O  \nATOM   2631  CG2 THR A 332      11.182   1.554  -2.054  1.00 97.31           C  \nATOM   2632  OG1 THR A 332      11.527  -0.469  -3.257  1.00 97.31           O  \nATOM   2633  N   ARG A 333      14.827   1.123  -0.575  1.00 96.92           N  \nATOM   2634  CA  ARG A 333      15.606   2.013   0.304  1.00 96.92           C  \nATOM   2635  C   ARG A 333      16.711   2.765  -0.446  1.00 96.92           C  \nATOM   2636  CB  ARG A 333      16.165   1.240   1.509  1.00 96.92           C  \nATOM   2637  O   ARG A 333      17.026   3.888  -0.064  1.00 96.92           O  \nATOM   2638  CG  ARG A 333      17.238   0.212   1.120  1.00 96.92           C  \nATOM   2639  CD  ARG A 333      17.720  -0.582   2.334  1.00 96.92           C  \nATOM   2640  NE  ARG A 333      18.690  -1.605   1.925  1.00 96.92           N  \nATOM   2641  NH1 ARG A 333      20.629  -0.408   2.133  1.00 96.92           N  \nATOM   2642  NH2 ARG A 333      20.692  -2.507   1.376  1.00 96.92           N  \nATOM   2643  CZ  ARG A 333      19.997  -1.504   1.814  1.00 96.92           C  \nATOM   2644  N   PHE A 334      17.283   2.182  -1.503  1.00 98.17           N  \nATOM   2645  CA  PHE A 334      18.263   2.868  -2.342  1.00 98.17           C  \nATOM   2646  C   PHE A 334      17.620   3.986  -3.157  1.00 98.17           C  \nATOM   2647  CB  PHE A 334      18.988   1.889  -3.272  1.00 98.17           C  \nATOM   2648  O   PHE A 334      18.245   5.029  -3.302  1.00 98.17           O  \nATOM   2649  CG  PHE A 334      19.825   0.815  -2.603  1.00 98.17           C  \nATOM   2650  CD1 PHE A 334      20.549   1.076  -1.423  1.00 98.17           C  \nATOM   2651  CD2 PHE A 334      19.958  -0.432  -3.234  1.00 98.17           C  \nATOM   2652  CE1 PHE A 334      21.404   0.096  -0.893  1.00 98.17           C  \nATOM   2653  CE2 PHE A 334      20.781  -1.428  -2.681  1.00 98.17           C  \nATOM   2654  CZ  PHE A 334      21.510  -1.161  -1.512  1.00 98.17           C  \nATOM   2655  N   VAL A 335      16.370   3.824  -3.606  1.00 98.49           N  \nATOM   2656  CA  VAL A 335      15.610   4.893  -4.281  1.00 98.49           C  \nATOM   2657  C   VAL A 335      15.489   6.109  -3.358  1.00 98.49           C  \nATOM   2658  CB  VAL A 335      14.217   4.411  -4.743  1.00 98.49           C  \nATOM   2659  O   VAL A 335      15.945   7.198  -3.712  1.00 98.49           O  \nATOM   2660  CG1 VAL A 335      13.522   5.460  -5.615  1.00 98.49           C  \nATOM   2661  CG2 VAL A 335      14.302   3.115  -5.563  1.00 98.49           C  \nATOM   2662  N   SER A 336      15.013   5.905  -2.123  1.00 97.98           N  \nATOM   2663  CA  SER A 336      14.899   6.980  -1.128  1.00 97.98           C  \nATOM   2664  C   SER A 336      16.247   7.628  -0.802  1.00 97.98           C  \nATOM   2665  CB  SER A 336      14.296   6.456   0.181  1.00 97.98           C  \nATOM   2666  O   SER A 336      16.342   8.848  -0.676  1.00 97.98           O  \nATOM   2667  OG  SER A 336      13.047   5.835  -0.043  1.00 97.98           O  \nATOM   2668  N   GLN A 337      17.304   6.824  -0.666  1.00 97.83           N  \nATOM   2669  CA  GLN A 337      18.648   7.309  -0.348  1.00 97.83           C  \nATOM   2670  C   GLN A 337      19.269   8.113  -1.496  1.00 97.83           C  \nATOM   2671  CB  GLN A 337      19.538   6.114   0.007  1.00 97.83           C  \nATOM   2672  O   GLN A 337      19.897   9.136  -1.245  1.00 97.83           O  \nATOM   2673  CG  GLN A 337      19.282   5.582   1.424  1.00 97.83           C  \nATOM   2674  CD  GLN A 337      20.141   4.370   1.775  1.00 97.83           C  \nATOM   2675  NE2 GLN A 337      20.156   3.967   3.026  1.00 97.83           N  \nATOM   2676  OE1 GLN A 337      20.843   3.777   0.972  1.00 97.83           O  \nATOM   2677  N   VAL A 338      19.078   7.681  -2.744  1.00 98.21           N  \nATOM   2678  CA  VAL A 338      19.546   8.400  -3.935  1.00 98.21           C  \nATOM   2679  C   VAL A 338      18.861   9.761  -4.050  1.00 98.21           C  \nATOM   2680  CB  VAL A 338      19.325   7.539  -5.196  1.00 98.21           C  \nATOM   2681  O   VAL A 338      19.533  10.760  -4.296  1.00 98.21           O  \nATOM   2682  CG1 VAL A 338      19.420   8.341  -6.496  1.00 98.21           C  \nATOM   2683  CG2 VAL A 338      20.366   6.412  -5.278  1.00 98.21           C  \nATOM   2684  N   GLU A 339      17.547   9.832  -3.827  1.00 97.40           N  \nATOM   2685  CA  GLU A 339      16.816  11.108  -3.869  1.00 97.40           C  \nATOM   2686  C   GLU A 339      17.084  12.019  -2.664  1.00 97.40           C  \nATOM   2687  CB  GLU A 339      15.312  10.857  -4.028  1.00 97.40           C  \nATOM   2688  O   GLU A 339      16.868  13.226  -2.758  1.00 97.40           O  \nATOM   2689  CG  GLU A 339      14.998  10.443  -5.467  1.00 97.40           C  \nATOM   2690  CD  GLU A 339      13.502  10.504  -5.770  1.00 97.40           C  \nATOM   2691  OE1 GLU A 339      12.998   9.538  -6.366  1.00 97.40           O  \nATOM   2692  OE2 GLU A 339      12.828  11.535  -5.494  1.00 97.40           O  \nATOM   2693  N   SER A 340      17.595  11.470  -1.559  1.00 96.59           N  \nATOM   2694  CA  SER A 340      18.015  12.247  -0.384  1.00 96.59           C  \nATOM   2695  C   SER A 340      19.433  12.823  -0.509  1.00 96.59           C  \nATOM   2696  CB  SER A 340      17.928  11.401   0.888  1.00 96.59           C  \nATOM   2697  O   SER A 340      19.869  13.557   0.379  1.00 96.59           O  \nATOM   2698  OG  SER A 340      16.627  10.882   1.087  1.00 96.59           O  \nATOM   2699  N   ASP A 341      20.172  12.502  -1.580  1.00 95.32           N  \nATOM   2700  CA  ASP A 341      21.537  12.992  -1.779  1.00 95.32           C  \nATOM   2701  C   ASP A 341      21.554  14.524  -1.928  1.00 95.32           C  \nATOM   2702  CB  ASP A 341      22.202  12.281  -2.970  1.00 95.32           C  \nATOM   2703  O   ASP A 341      20.827  15.121  -2.736  1.00 95.32           O  \nATOM   2704  CG  ASP A 341      23.699  12.604  -3.116  1.00 95.32           C  \nATOM   2705  OD1 ASP A 341      24.016  13.744  -3.536  1.00 95.32           O  \nATOM   2706  OD2 ASP A 341      24.541  11.703  -2.874  1.00 95.32           O  \nATOM   2707  N   THR A 342      22.439  15.159  -1.158  1.00 87.19           N  \nATOM   2708  CA  THR A 342      22.571  16.620  -1.035  1.00 87.19           C  \nATOM   2709  C   THR A 342      23.100  17.301  -2.302  1.00 87.19           C  \nATOM   2710  CB  THR A 342      23.482  16.972   0.152  1.00 87.19           C  \nATOM   2711  O   THR A 342      23.176  18.528  -2.353  1.00 87.19           O  \nATOM   2712  CG2 THR A 342      22.951  16.442   1.486  1.00 87.19           C  \nATOM   2713  OG1 THR A 342      24.759  16.408  -0.045  1.00 87.19           O  \nATOM   2714  N   GLY A 343      23.463  16.525  -3.329  1.00 88.28           N  \nATOM   2715  CA  GLY A 343      24.045  16.983  -4.589  1.00 88.28           C  \nATOM   2716  C   GLY A 343      25.556  16.751  -4.680  1.00 88.28           C  \nATOM   2717  O   GLY A 343      26.143  16.958  -5.744  1.00 88.28           O  \nATOM   2718  N   ASP A 344      26.197  16.296  -3.596  1.00 92.51           N  \nATOM   2719  CA  ASP A 344      27.616  15.926  -3.600  1.00 92.51           C  \nATOM   2720  C   ASP A 344      27.880  14.522  -4.176  1.00 92.51           C  \nATOM   2721  CB  ASP A 344      28.261  16.183  -2.224  1.00 92.51           C  \nATOM   2722  O   ASP A 344      29.037  14.176  -4.432  1.00 92.51           O  \nATOM   2723  CG  ASP A 344      28.088  15.097  -1.154  1.00 92.51           C  \nATOM   2724  OD1 ASP A 344      27.431  14.068  -1.410  1.00 92.51           O  \nATOM   2725  OD2 ASP A 344      28.753  15.256  -0.095  1.00 92.51           O  \nATOM   2726  N   ARG A 345      26.810  13.759  -4.455  1.00 95.75           N  \nATOM   2727  CA  ARG A 345      26.798  12.432  -5.091  1.00 95.75           C  \nATOM   2728  C   ARG A 345      27.465  11.334  -4.270  1.00 95.75           C  \nATOM   2729  CB  ARG A 345      27.377  12.488  -6.516  1.00 95.75           C  \nATOM   2730  O   ARG A 345      27.610  10.220  -4.781  1.00 95.75           O  \nATOM   2731  CG  ARG A 345      26.764  13.563  -7.421  1.00 95.75           C  \nATOM   2732  CD  ARG A 345      27.605  13.657  -8.694  1.00 95.75           C  \nATOM   2733  NE  ARG A 345      27.068  14.663  -9.612  1.00 95.75           N  \nATOM   2734  NH1 ARG A 345      28.205  16.510  -8.874  1.00 95.75           N  \nATOM   2735  NH2 ARG A 345      26.822  16.634 -10.649  1.00 95.75           N  \nATOM   2736  CZ  ARG A 345      27.372  15.936  -9.701  1.00 95.75           C  \nATOM   2737  N   LYS A 346      27.904  11.594  -3.034  1.00 95.92           N  \nATOM   2738  CA  LYS A 346      28.626  10.591  -2.235  1.00 95.92           C  \nATOM   2739  C   LYS A 346      27.734   9.415  -1.878  1.00 95.92           C  \nATOM   2740  CB  LYS A 346      29.159  11.207  -0.942  1.00 95.92           C  \nATOM   2741  O   LYS A 346      28.193   8.274  -1.895  1.00 95.92           O  \nATOM   2742  CG  LYS A 346      30.309  12.184  -1.188  1.00 95.92           C  \nATOM   2743  CD  LYS A 346      30.830  12.648   0.172  1.00 95.92           C  \nATOM   2744  CE  LYS A 346      31.785  13.827   0.001  1.00 95.92           C  \nATOM   2745  NZ  LYS A 346      31.323  14.949   0.842  1.00 95.92           N  \nATOM   2746  N   GLN A 347      26.470   9.678  -1.561  1.00 96.68           N  \nATOM   2747  CA  GLN A 347      25.531   8.630  -1.186  1.00 96.68           C  \nATOM   2748  C   GLN A 347      25.226   7.736  -2.387  1.00 96.68           C  \nATOM   2749  CB  GLN A 347      24.284   9.292  -0.601  1.00 96.68           C  \nATOM   2750  O   GLN A 347      25.314   6.513  -2.280  1.00 96.68           O  \nATOM   2751  CG  GLN A 347      23.278   8.281  -0.046  1.00 96.68           C  \nATOM   2752  CD  GLN A 347      22.241   8.960   0.843  1.00 96.68           C  \nATOM   2753  NE2 GLN A 347      21.460   8.205   1.576  1.00 96.68           N  \nATOM   2754  OE1 GLN A 347      22.150  10.167   0.967  1.00 96.68           O  \nATOM   2755  N   ILE A 348      24.983   8.352  -3.545  1.00 98.09           N  \nATOM   2756  CA  ILE A 348      24.764   7.644  -4.812  1.00 98.09           C  \nATOM   2757  C   ILE A 348      25.998   6.807  -5.177  1.00 98.09           C  \nATOM   2758  CB  ILE A 348      24.400   8.641  -5.937  1.00 98.09           C  \nATOM   2759  O   ILE A 348      25.877   5.616  -5.462  1.00 98.09           O  \nATOM   2760  CG1 ILE A 348      23.217   9.550  -5.531  1.00 98.09           C  \nATOM   2761  CG2 ILE A 348      24.068   7.851  -7.217  1.00 98.09           C  \nATOM   2762  CD1 ILE A 348      22.910  10.669  -6.530  1.00 98.09           C  \nATOM   2763  N   TYR A 349      27.196   7.395  -5.092  1.00 98.15           N  \nATOM   2764  CA  TYR A 349      28.457   6.702  -5.365  1.00 98.15           C  \nATOM   2765  C   TYR A 349      28.641   5.472  -4.465  1.00 98.15           C  \nATOM   2766  CB  TYR A 349      29.629   7.682  -5.198  1.00 98.15           C  \nATOM   2767  O   TYR A 349      29.009   4.401  -4.951  1.00 98.15           O  \nATOM   2768  CG  TYR A 349      30.973   7.084  -5.568  1.00 98.15           C  \nATOM   2769  CD1 TYR A 349      31.678   6.290  -4.641  1.00 98.15           C  \nATOM   2770  CD2 TYR A 349      31.499   7.285  -6.858  1.00 98.15           C  \nATOM   2771  CE1 TYR A 349      32.876   5.658  -5.021  1.00 98.15           C  \nATOM   2772  CE2 TYR A 349      32.698   6.655  -7.243  1.00 98.15           C  \nATOM   2773  OH  TYR A 349      34.527   5.197  -6.696  1.00 98.15           O  \nATOM   2774  CZ  TYR A 349      33.382   5.830  -6.328  1.00 98.15           C  \nATOM   2775  N   ASN A 350      28.362   5.601  -3.165  1.00 97.47           N  \nATOM   2776  CA  ASN A 350      28.494   4.504  -2.207  1.00 97.47           C  \nATOM   2777  C   ASN A 350      27.515   3.364  -2.504  1.00 97.47           C  \nATOM   2778  CB  ASN A 350      28.298   5.044  -0.782  1.00 97.47           C  \nATOM   2779  O   ASN A 350      27.929   2.208  -2.517  1.00 97.47           O  \nATOM   2780  CG  ASN A 350      29.467   5.877  -0.290  1.00 97.47           C  \nATOM   2781  ND2 ASN A 350      29.255   6.672   0.733  1.00 97.47           N  \nATOM   2782  OD1 ASN A 350      30.586   5.805  -0.770  1.00 97.47           O  \nATOM   2783  N   ILE A 351      26.248   3.674  -2.798  1.00 97.71           N  \nATOM   2784  CA  ILE A 351      25.242   2.666  -3.169  1.00 97.71           C  \nATOM   2785  C   ILE A 351      25.695   1.910  -4.416  1.00 97.71           C  \nATOM   2786  CB  ILE A 351      23.864   3.332  -3.372  1.00 97.71           C  \nATOM   2787  O   ILE A 351      25.800   0.686  -4.396  1.00 97.71           O  \nATOM   2788  CG1 ILE A 351      23.329   3.817  -2.009  1.00 97.71           C  \nATOM   2789  CG2 ILE A 351      22.851   2.374  -4.027  1.00 97.71           C  \nATOM   2790  CD1 ILE A 351      22.163   4.799  -2.134  1.00 97.71           C  \nATOM   2791  N   LEU A 352      26.057   2.621  -5.481  1.00 98.23           N  \nATOM   2792  CA  LEU A 352      26.507   1.992  -6.723  1.00 98.23           C  \nATOM   2793  C   LEU A 352      27.797   1.176  -6.524  1.00 98.23           C  \nATOM   2794  CB  LEU A 352      26.670   3.096  -7.772  1.00 98.23           C  \nATOM   2795  O   LEU A 352      27.936   0.097  -7.096  1.00 98.23           O  \nATOM   2796  CG  LEU A 352      25.347   3.785  -8.163  1.00 98.23           C  \nATOM   2797  CD1 LEU A 352      25.637   4.962  -9.091  1.00 98.23           C  \nATOM   2798  CD2 LEU A 352      24.385   2.822  -8.859  1.00 98.23           C  \nATOM   2799  N   SER A 353      28.695   1.620  -5.641  1.00 97.19           N  \nATOM   2800  CA  SER A 353      29.888   0.853  -5.256  1.00 97.19           C  \nATOM   2801  C   SER A 353      29.543  -0.465  -4.555  1.00 97.19           C  \nATOM   2802  CB  SER A 353      30.812   1.679  -4.358  1.00 97.19           C  \nATOM   2803  O   SER A 353      30.184  -1.480  -4.830  1.00 97.19           O  \nATOM   2804  OG  SER A 353      31.270   2.841  -5.020  1.00 97.19           O  \nATOM   2805  N   THR A 354      28.513  -0.495  -3.696  1.00 96.46           N  \nATOM   2806  CA  THR A 354      28.027  -1.756  -3.089  1.00 96.46           C  \nATOM   2807  C   THR A 354      27.432  -2.720  -4.113  1.00 96.46           C  \nATOM   2808  CB  THR A 354      27.016  -1.554  -1.948  1.00 96.46           C  \nATOM   2809  O   THR A 354      27.486  -3.931  -3.916  1.00 96.46           O  \nATOM   2810  CG2 THR A 354      27.591  -0.755  -0.785  1.00 96.46           C  \nATOM   2811  OG1 THR A 354      25.813  -0.930  -2.316  1.00 96.46           O  \nATOM   2812  N   LEU A 355      26.956  -2.200  -5.246  1.00 96.99           N  \nATOM   2813  CA  LEU A 355      26.518  -2.983  -6.400  1.00 96.99           C  \nATOM   2814  C   LEU A 355      27.678  -3.339  -7.343  1.00 96.99           C  \nATOM   2815  CB  LEU A 355      25.376  -2.241  -7.119  1.00 96.99           C  \nATOM   2816  O   LEU A 355      27.434  -3.759  -8.465  1.00 96.99           O  \nATOM   2817  CG  LEU A 355      24.112  -2.043  -6.262  1.00 96.99           C  \nATOM   2818  CD1 LEU A 355      23.136  -1.131  -7.002  1.00 96.99           C  \nATOM   2819  CD2 LEU A 355      23.409  -3.370  -5.971  1.00 96.99           C  \nATOM   2820  N   GLY A 356      28.940  -3.181  -6.936  1.00 96.65           N  \nATOM   2821  CA  GLY A 356      30.102  -3.558  -7.749  1.00 96.65           C  \nATOM   2822  C   GLY A 356      30.396  -2.616  -8.922  1.00 96.65           C  \nATOM   2823  O   GLY A 356      31.134  -2.996  -9.829  1.00 96.65           O  \nATOM   2824  N   LEU A 357      29.838  -1.403  -8.922  1.00 96.66           N  \nATOM   2825  CA  LEU A 357      30.019  -0.410  -9.984  1.00 96.66           C  \nATOM   2826  C   LEU A 357      31.025   0.670  -9.561  1.00 96.66           C  \nATOM   2827  CB  LEU A 357      28.656   0.199 -10.357  1.00 96.66           C  \nATOM   2828  O   LEU A 357      31.198   0.960  -8.380  1.00 96.66           O  \nATOM   2829  CG  LEU A 357      27.621  -0.835 -10.844  1.00 96.66           C  \nATOM   2830  CD1 LEU A 357      26.217  -0.272 -10.668  1.00 96.66           C  \nATOM   2831  CD2 LEU A 357      27.847  -1.199 -12.311  1.00 96.66           C  \nATOM   2832  N   ARG A 358      31.679   1.307 -10.536  1.00 94.44           N  \nATOM   2833  CA  ARG A 358      32.534   2.489 -10.324  1.00 94.44           C  \nATOM   2834  C   ARG A 358      31.951   3.668 -11.104  1.00 94.44           C  \nATOM   2835  CB  ARG A 358      33.983   2.190 -10.727  1.00 94.44           C  \nATOM   2836  O   ARG A 358      32.379   3.903 -12.233  1.00 94.44           O  \nATOM   2837  CG  ARG A 358      34.644   1.181  -9.784  1.00 94.44           C  \nATOM   2838  CD  ARG A 358      36.095   0.975 -10.220  1.00 94.44           C  \nATOM   2839  NE  ARG A 358      36.766  -0.035  -9.385  1.00 94.44           N  \nATOM   2840  NH1 ARG A 358      38.642  -0.266 -10.683  1.00 94.44           N  \nATOM   2841  NH2 ARG A 358      38.407  -1.515  -8.846  1.00 94.44           N  \nATOM   2842  CZ  ARG A 358      37.932  -0.597  -9.639  1.00 94.44           C  \nATOM   2843  N   PRO A 359      30.939   4.359 -10.557  1.00 95.90           N  \nATOM   2844  CA  PRO A 359      30.183   5.345 -11.316  1.00 95.90           C  \nATOM   2845  C   PRO A 359      30.984   6.634 -11.532  1.00 95.90           C  \nATOM   2846  CB  PRO A 359      28.918   5.582 -10.493  1.00 95.90           C  \nATOM   2847  O   PRO A 359      31.688   7.112 -10.639  1.00 95.90           O  \nATOM   2848  CG  PRO A 359      29.421   5.399  -9.066  1.00 95.90           C  \nATOM   2849  CD  PRO A 359      30.406   4.241  -9.202  1.00 95.90           C  \nATOM   2850  N   SER A 360      30.835   7.232 -12.712  1.00 95.35           N  \nATOM   2851  CA  SER A 360      31.219   8.625 -12.943  1.00 95.35           C  \nATOM   2852  C   SER A 360      30.215   9.587 -12.293  1.00 95.35           C  \nATOM   2853  CB  SER A 360      31.350   8.894 -14.446  1.00 95.35           C  \nATOM   2854  O   SER A 360      29.111   9.202 -11.905  1.00 95.35           O  \nATOM   2855  OG  SER A 360      30.088   8.869 -15.078  1.00 95.35           O  \nATOM   2856  N   THR A 361      30.556  10.877 -12.223  1.00 94.67           N  \nATOM   2857  CA  THR A 361      29.615  11.913 -11.760  1.00 94.67           C  \nATOM   2858  C   THR A 361      28.344  11.952 -12.605  1.00 94.67           C  \nATOM   2859  CB  THR A 361      30.263  13.304 -11.791  1.00 94.67           C  \nATOM   2860  O   THR A 361      27.255  12.113 -12.065  1.00 94.67           O  \nATOM   2861  CG2 THR A 361      31.375  13.423 -10.750  1.00 94.67           C  \nATOM   2862  OG1 THR A 361      30.851  13.554 -13.053  1.00 94.67           O  \nATOM   2863  N   THR A 362      28.481  11.760 -13.920  1.00 94.45           N  \nATOM   2864  CA  THR A 362      27.354  11.707 -14.854  1.00 94.45           C  \nATOM   2865  C   THR A 362      26.495  10.469 -14.624  1.00 94.45           C  \nATOM   2866  CB  THR A 362      27.868  11.719 -16.300  1.00 94.45           C  \nATOM   2867  O   THR A 362      25.277  10.572 -14.697  1.00 94.45           O  \nATOM   2868  CG2 THR A 362      26.753  11.787 -17.342  1.00 94.45           C  \nATOM   2869  OG1 THR A 362      28.689  12.847 -16.503  1.00 94.45           O  \nATOM   2870  N   ASP A 363      27.092   9.317 -14.308  1.00 97.00           N  \nATOM   2871  CA  ASP A 363      26.313   8.115 -13.993  1.00 97.00           C  \nATOM   2872  C   ASP A 363      25.495   8.304 -12.709  1.00 97.00           C  \nATOM   2873  CB  ASP A 363      27.206   6.880 -13.857  1.00 97.00           C  \nATOM   2874  O   ASP A 363      24.325   7.933 -12.675  1.00 97.00           O  \nATOM   2875  CG  ASP A 363      28.017   6.552 -15.109  1.00 97.00           C  \nATOM   2876  OD1 ASP A 363      27.462   6.527 -16.232  1.00 97.00           O  \nATOM   2877  OD2 ASP A 363      29.243   6.370 -14.938  1.00 97.00           O  \nATOM   2878  N   CYS A 364      26.065   8.944 -11.679  1.00 97.84           N  \nATOM   2879  CA  CYS A 364      25.316   9.287 -10.467  1.00 97.84           C  \nATOM   2880  C   CYS A 364      24.115  10.198 -10.771  1.00 97.84           C  \nATOM   2881  CB  CYS A 364      26.235   9.971  -9.446  1.00 97.84           C  \nATOM   2882  O   CYS A 364      23.026   9.966 -10.248  1.00 97.84           O  \nATOM   2883  SG  CYS A 364      27.482   8.823  -8.792  1.00 97.84           S  \nATOM   2884  N   ASP A 365      24.298  11.204 -11.632  1.00 96.57           N  \nATOM   2885  CA  ASP A 365      23.218  12.114 -12.029  1.00 96.57           C  \nATOM   2886  C   ASP A 365      22.114  11.366 -12.800  1.00 96.57           C  \nATOM   2887  CB  ASP A 365      23.786  13.295 -12.845  1.00 96.57           C  \nATOM   2888  O   ASP A 365      20.932  11.572 -12.538  1.00 96.57           O  \nATOM   2889  CG  ASP A 365      24.688  14.246 -12.036  1.00 96.57           C  \nATOM   2890  OD1 ASP A 365      24.616  14.263 -10.790  1.00 96.57           O  \nATOM   2891  OD2 ASP A 365      25.488  15.011 -12.627  1.00 96.57           O  \nATOM   2892  N   ILE A 366      22.476  10.441 -13.695  1.00 97.98           N  \nATOM   2893  CA  ILE A 366      21.510   9.618 -14.442  1.00 97.98           C  \nATOM   2894  C   ILE A 366      20.736   8.680 -13.506  1.00 97.98           C  \nATOM   2895  CB  ILE A 366      22.225   8.843 -15.570  1.00 97.98           C  \nATOM   2896  O   ILE A 366      19.514   8.591 -13.610  1.00 97.98           O  \nATOM   2897  CG1 ILE A 366      22.737   9.823 -16.651  1.00 97.98           C  \nATOM   2898  CG2 ILE A 366      21.282   7.807 -16.209  1.00 97.98           C  \nATOM   2899  CD1 ILE A 366      23.715   9.190 -17.646  1.00 97.98           C  \nATOM   2900  N   VAL A 367      21.414   8.017 -12.563  1.00 98.54           N  \nATOM   2901  CA  VAL A 367      20.761   7.141 -11.572  1.00 98.54           C  \nATOM   2902  C   VAL A 367      19.773   7.930 -10.719  1.00 98.54           C  \nATOM   2903  CB  VAL A 367      21.808   6.433 -10.692  1.00 98.54           C  \nATOM   2904  O   VAL A 367      18.657   7.468 -10.492  1.00 98.54           O  \nATOM   2905  CG1 VAL A 367      21.197   5.704  -9.486  1.00 98.54           C  \nATOM   2906  CG2 VAL A 367      22.559   5.387 -11.522  1.00 98.54           C  \nATOM   2907  N   ARG A 368      20.139   9.150 -10.306  1.00 98.12           N  \nATOM   2908  CA  ARG A 368      19.220  10.052  -9.604  1.00 98.12           C  \nATOM   2909  C   ARG A 368      17.973  10.346 -10.432  1.00 98.12           C  \nATOM   2910  CB  ARG A 368      19.963  11.330  -9.203  1.00 98.12           C  \nATOM   2911  O   ARG A 368      16.867  10.208  -9.918  1.00 98.12           O  \nATOM   2912  CG  ARG A 368      19.072  12.262  -8.378  1.00 98.12           C  \nATOM   2913  CD  ARG A 368      19.839  13.530  -8.013  1.00 98.12           C  \nATOM   2914  NE  ARG A 368      18.976  14.444  -7.250  1.00 98.12           N  \nATOM   2915  NH1 ARG A 368      20.544  15.197  -5.731  1.00 98.12           N  \nATOM   2916  NH2 ARG A 368      18.407  15.731  -5.473  1.00 98.12           N  \nATOM   2917  CZ  ARG A 368      19.317  15.126  -6.172  1.00 98.12           C  \nATOM   2918  N   ARG A 369      18.138  10.691 -11.711  1.00 97.78           N  \nATOM   2919  CA  ARG A 369      17.013  10.969 -12.619  1.00 97.78           C  \nATOM   2920  C   ARG A 369      16.116   9.748 -12.830  1.00 97.78           C  \nATOM   2921  CB  ARG A 369      17.541  11.503 -13.962  1.00 97.78           C  \nATOM   2922  O   ARG A 369      14.897   9.906 -12.881  1.00 97.78           O  \nATOM   2923  CG  ARG A 369      18.216  12.881 -13.872  1.00 97.78           C  \nATOM   2924  CD  ARG A 369      17.252  14.011 -13.517  1.00 97.78           C  \nATOM   2925  NE  ARG A 369      16.293  14.269 -14.605  1.00 97.78           N  \nATOM   2926  NH1 ARG A 369      14.565  15.005 -13.275  1.00 97.78           N  \nATOM   2927  NH2 ARG A 369      14.344  14.912 -15.526  1.00 97.78           N  \nATOM   2928  CZ  ARG A 369      15.070  14.728 -14.456  1.00 97.78           C  \nATOM   2929  N   ALA A 370      16.683   8.544 -12.904  1.00 98.71           N  \nATOM   2930  CA  ALA A 370      15.912   7.305 -12.997  1.00 98.71           C  \nATOM   2931  C   ALA A 370      15.062   7.065 -11.736  1.00 98.71           C  \nATOM   2932  CB  ALA A 370      16.866   6.141 -13.289  1.00 98.71           C  \nATOM   2933  O   ALA A 370      13.857   6.840 -11.853  1.00 98.71           O  \nATOM   2934  N   CYS A 371      15.654   7.198 -10.541  1.00 98.71           N  \nATOM   2935  CA  CYS A 371      14.924   7.123  -9.269  1.00 98.71           C  \nATOM   2936  C   CYS A 371      13.780   8.148  -9.208  1.00 98.71           C  \nATOM   2937  CB  CYS A 371      15.894   7.338  -8.098  1.00 98.71           C  \nATOM   2938  O   CYS A 371      12.632   7.763  -8.988  1.00 98.71           O  \nATOM   2939  SG  CYS A 371      16.998   5.911  -7.895  1.00 98.71           S  \nATOM   2940  N   GLU A 372      14.083   9.421  -9.498  1.00 98.25           N  \nATOM   2941  CA  GLU A 372      13.103  10.515  -9.503  1.00 98.25           C  \nATOM   2942  C   GLU A 372      11.940  10.244 -10.462  1.00 98.25           C  \nATOM   2943  CB  GLU A 372      13.785  11.841  -9.899  1.00 98.25           C  \nATOM   2944  O   GLU A 372      10.793  10.547 -10.137  1.00 98.25           O  \nATOM   2945  CG  GLU A 372      14.665  12.455  -8.795  1.00 98.25           C  \nATOM   2946  CD  GLU A 372      15.472  13.693  -9.252  1.00 98.25           C  \nATOM   2947  OE1 GLU A 372      16.250  14.217  -8.409  1.00 98.25           O  \nATOM   2948  OE2 GLU A 372      15.337  14.122 -10.431  1.00 98.25           O  \nATOM   2949  N   SER A 373      12.212   9.667 -11.634  1.00 98.67           N  \nATOM   2950  CA  SER A 373      11.188   9.380 -12.645  1.00 98.67           C  \nATOM   2951  C   SER A 373      10.227   8.285 -12.176  1.00 98.67           C  \nATOM   2952  CB  SER A 373      11.845   8.999 -13.975  1.00 98.67           C  \nATOM   2953  O   SER A 373       9.009   8.467 -12.228  1.00 98.67           O  \nATOM   2954  OG  SER A 373      12.676  10.057 -14.414  1.00 98.67           O  \nATOM   2955  N   VAL A 374      10.760   7.183 -11.637  1.00 98.79           N  \nATOM   2956  CA  VAL A 374       9.952   6.068 -11.118  1.00 98.79           C  \nATOM   2957  C   VAL A 374       9.122   6.505  -9.908  1.00 98.79           C  \nATOM   2958  CB  VAL A 374      10.841   4.856 -10.768  1.00 98.79           C  \nATOM   2959  O   VAL A 374       7.913   6.266  -9.874  1.00 98.79           O  \nATOM   2960  CG1 VAL A 374      10.036   3.714 -10.132  1.00 98.79           C  \nATOM   2961  CG2 VAL A 374      11.514   4.283 -12.022  1.00 98.79           C  \nATOM   2962  N   SER A 375       9.735   7.180  -8.931  1.00 98.58           N  \nATOM   2963  CA  SER A 375       9.045   7.597  -7.705  1.00 98.58           C  \nATOM   2964  C   SER A 375       8.007   8.698  -7.964  1.00 98.58           C  \nATOM   2965  CB  SER A 375      10.065   8.052  -6.662  1.00 98.58           C  \nATOM   2966  O   SER A 375       6.941   8.698  -7.346  1.00 98.58           O  \nATOM   2967  OG  SER A 375      10.607   9.287  -7.064  1.00 98.58           O  \nATOM   2968  N   THR A 376       8.263   9.608  -8.914  1.00 98.64           N  \nATOM   2969  CA  THR A 376       7.288  10.626  -9.340  1.00 98.64           C  \nATOM   2970  C   THR A 376       6.085   9.982 -10.015  1.00 98.64           C  \nATOM   2971  CB  THR A 376       7.910  11.668 -10.279  1.00 98.64           C  \nATOM   2972  O   THR A 376       4.952  10.313  -9.665  1.00 98.64           O  \nATOM   2973  CG2 THR A 376       6.918  12.742 -10.726  1.00 98.64           C  \nATOM   2974  OG1 THR A 376       8.946  12.332  -9.601  1.00 98.64           O  \nATOM   2975  N   ARG A 377       6.304   9.023 -10.925  1.00 98.72           N  \nATOM   2976  CA  ARG A 377       5.209   8.274 -11.553  1.00 98.72           C  \nATOM   2977  C   ARG A 377       4.373   7.533 -10.510  1.00 98.72           C  \nATOM   2978  CB  ARG A 377       5.777   7.311 -12.601  1.00 98.72           C  \nATOM   2979  O   ARG A 377       3.151   7.622 -10.553  1.00 98.72           O  \nATOM   2980  CG  ARG A 377       4.652   6.676 -13.438  1.00 98.72           C  \nATOM   2981  CD  ARG A 377       5.182   5.602 -14.387  1.00 98.72           C  \nATOM   2982  NE  ARG A 377       5.740   4.459 -13.640  1.00 98.72           N  \nATOM   2983  NH1 ARG A 377       5.807   2.958 -15.370  1.00 98.72           N  \nATOM   2984  NH2 ARG A 377       6.399   2.325 -13.327  1.00 98.72           N  \nATOM   2985  CZ  ARG A 377       5.988   3.260 -14.124  1.00 98.72           C  \nATOM   2986  N   ALA A 378       5.012   6.871  -9.544  1.00 98.75           N  \nATOM   2987  CA  ALA A 378       4.325   6.191  -8.445  1.00 98.75           C  \nATOM   2988  C   ALA A 378       3.463   7.159  -7.611  1.00 98.75           C  \nATOM   2989  CB  ALA A 378       5.382   5.488  -7.585  1.00 98.75           C  \nATOM   2990  O   ALA A 378       2.293   6.877  -7.348  1.00 98.75           O  \nATOM   2991  N   ALA A 379       4.001   8.330  -7.247  1.00 98.78           N  \nATOM   2992  CA  ALA A 379       3.260   9.357  -6.513  1.00 98.78           C  \nATOM   2993  C   ALA A 379       2.065   9.897  -7.316  1.00 98.78           C  \nATOM   2994  CB  ALA A 379       4.230  10.483  -6.130  1.00 98.78           C  \nATOM   2995  O   ALA A 379       0.981  10.097  -6.764  1.00 98.78           O  \nATOM   2996  N   HIS A 380       2.242  10.103  -8.622  1.00 98.81           N  \nATOM   2997  CA  HIS A 380       1.180  10.556  -9.515  1.00 98.81           C  \nATOM   2998  C   HIS A 380       0.085   9.503  -9.704  1.00 98.81           C  \nATOM   2999  CB  HIS A 380       1.779  10.962 -10.863  1.00 98.81           C  \nATOM   3000  O   HIS A 380      -1.090   9.841  -9.561  1.00 98.81           O  \nATOM   3001  CG  HIS A 380       2.546  12.259 -10.876  1.00 98.81           C  \nATOM   3002  CD2 HIS A 380       2.715  13.154  -9.850  1.00 98.81           C  \nATOM   3003  ND1 HIS A 380       3.147  12.803 -11.986  1.00 98.81           N  \nATOM   3004  CE1 HIS A 380       3.672  13.988 -11.638  1.00 98.81           C  \nATOM   3005  NE2 HIS A 380       3.424  14.256 -10.344  1.00 98.81           N  \nATOM   3006  N   MET A 381       0.441   8.237  -9.941  1.00 98.71           N  \nATOM   3007  CA  MET A 381      -0.532   7.144 -10.011  1.00 98.71           C  \nATOM   3008  C   MET A 381      -1.320   7.073  -8.705  1.00 98.71           C  \nATOM   3009  CB  MET A 381       0.153   5.808 -10.351  1.00 98.71           C  \nATOM   3010  O   MET A 381      -2.526   7.284  -8.731  1.00 98.71           O  \nATOM   3011  CG  MET A 381       0.622   5.767 -11.812  1.00 98.71           C  \nATOM   3012  SD  MET A 381      -0.717   5.914 -13.030  1.00 98.71           S  \nATOM   3013  CE  MET A 381      -1.249   4.191 -13.186  1.00 98.71           C  \nATOM   3014  N   CYS A 382      -0.641   6.971  -7.556  1.00 98.75           N  \nATOM   3015  CA  CYS A 382      -1.277   6.977  -6.235  1.00 98.75           C  \nATOM   3016  C   CYS A 382      -2.235   8.168  -6.037  1.00 98.75           C  \nATOM   3017  CB  CYS A 382      -0.158   6.984  -5.184  1.00 98.75           C  \nATOM   3018  O   CYS A 382      -3.330   8.001  -5.497  1.00 98.75           O  \nATOM   3019  SG  CYS A 382      -0.828   6.691  -3.523  1.00 98.75           S  \nATOM   3020  N   SER A 383      -1.853   9.367  -6.500  1.00 98.84           N  \nATOM   3021  CA  SER A 383      -2.701  10.562  -6.416  1.00 98.84           C  \nATOM   3022  C   SER A 383      -3.982  10.458  -7.241  1.00 98.84           C  \nATOM   3023  CB  SER A 383      -1.929  11.824  -6.807  1.00 98.84           C  \nATOM   3024  O   SER A 383      -5.022  10.918  -6.781  1.00 98.84           O  \nATOM   3025  OG  SER A 383      -1.737  11.972  -8.201  1.00 98.84           O  \nATOM   3026  N   ALA A 384      -3.928   9.835  -8.422  1.00 98.81           N  \nATOM   3027  CA  ALA A 384      -5.092   9.650  -9.279  1.00 98.81           C  \nATOM   3028  C   ALA A 384      -6.100   8.674  -8.658  1.00 98.81           C  \nATOM   3029  CB  ALA A 384      -4.617   9.192 -10.662  1.00 98.81           C  \nATOM   3030  O   ALA A 384      -7.302   8.930  -8.709  1.00 98.81           O  \nATOM   3031  N   GLY A 385      -5.618   7.608  -8.010  1.00 98.76           N  \nATOM   3032  CA  GLY A 385      -6.468   6.691  -7.244  1.00 98.76           C  \nATOM   3033  C   GLY A 385      -7.174   7.382  -6.082  1.00 98.76           C  \nATOM   3034  O   GLY A 385      -8.400   7.330  -5.997  1.00 98.76           O  \nATOM   3035  N   LEU A 386      -6.427   8.098  -5.226  1.00 98.83           N  \nATOM   3036  CA  LEU A 386      -7.032   8.837  -4.111  1.00 98.83           C  \nATOM   3037  C   LEU A 386      -8.006   9.914  -4.606  1.00 98.83           C  \nATOM   3038  CB  LEU A 386      -5.948   9.452  -3.205  1.00 98.83           C  \nATOM   3039  O   LEU A 386      -9.088  10.062  -4.044  1.00 98.83           O  \nATOM   3040  CG  LEU A 386      -6.561  10.303  -2.069  1.00 98.83           C  \nATOM   3041  CD1 LEU A 386      -7.463   9.489  -1.138  1.00 98.83           C  \nATOM   3042  CD2 LEU A 386      -5.492  10.997  -1.234  1.00 98.83           C  \nATOM   3043  N   ALA A 387      -7.654  10.652  -5.659  1.00 98.76           N  \nATOM   3044  CA  ALA A 387      -8.555  11.638  -6.244  1.00 98.76           C  \nATOM   3045  C   ALA A 387      -9.857  10.993  -6.743  1.00 98.76           C  \nATOM   3046  CB  ALA A 387      -7.828  12.376  -7.368  1.00 98.76           C  \nATOM   3047  O   ALA A 387     -10.919  11.588  -6.592  1.00 98.76           O  \nATOM   3048  N   GLY A 388      -9.793   9.766  -7.275  1.00 98.53           N  \nATOM   3049  CA  GLY A 388     -10.974   8.996  -7.663  1.00 98.53           C  \nATOM   3050  C   GLY A 388     -11.880   8.694  -6.469  1.00 98.53           C  \nATOM   3051  O   GLY A 388     -13.083   8.936  -6.541  1.00 98.53           O  \nATOM   3052  N   VAL A 389     -11.294   8.259  -5.349  1.00 98.67           N  \nATOM   3053  CA  VAL A 389     -12.026   8.021  -4.092  1.00 98.67           C  \nATOM   3054  C   VAL A 389     -12.666   9.307  -3.567  1.00 98.67           C  \nATOM   3055  CB  VAL A 389     -11.109   7.382  -3.027  1.00 98.67           C  \nATOM   3056  O   VAL A 389     -13.866   9.341  -3.315  1.00 98.67           O  \nATOM   3057  CG1 VAL A 389     -11.791   7.253  -1.659  1.00 98.67           C  \nATOM   3058  CG2 VAL A 389     -10.669   5.976  -3.451  1.00 98.67           C  \nATOM   3059  N   ILE A 390     -11.897  10.388  -3.452  1.00 98.50           N  \nATOM   3060  CA  ILE A 390     -12.374  11.659  -2.890  1.00 98.50           C  \nATOM   3061  C   ILE A 390     -13.462  12.286  -3.768  1.00 98.50           C  \nATOM   3062  CB  ILE A 390     -11.170  12.601  -2.669  1.00 98.50           C  \nATOM   3063  O   ILE A 390     -14.488  12.724  -3.251  1.00 98.50           O  \nATOM   3064  CG1 ILE A 390     -10.322  12.057  -1.496  1.00 98.50           C  \nATOM   3065  CG2 ILE A 390     -11.584  14.055  -2.393  1.00 98.50           C  \nATOM   3066  CD1 ILE A 390      -9.079  12.892  -1.183  1.00 98.50           C  \nATOM   3067  N   ASN A 391     -13.280  12.312  -5.092  1.00 97.99           N  \nATOM   3068  CA  ASN A 391     -14.293  12.860  -5.992  1.00 97.99           C  \nATOM   3069  C   ASN A 391     -15.575  12.021  -5.963  1.00 97.99           C  \nATOM   3070  CB  ASN A 391     -13.725  13.012  -7.411  1.00 97.99           C  \nATOM   3071  O   ASN A 391     -16.655  12.603  -5.922  1.00 97.99           O  \nATOM   3072  CG  ASN A 391     -12.769  14.188  -7.546  1.00 97.99           C  \nATOM   3073  ND2 ASN A 391     -11.775  14.080  -8.396  1.00 97.99           N  \nATOM   3074  OD1 ASN A 391     -12.906  15.233  -6.924  1.00 97.99           O  \nATOM   3075  N   ARG A 392     -15.472  10.685  -5.871  1.00 96.58           N  \nATOM   3076  CA  ARG A 392     -16.637   9.819  -5.643  1.00 96.58           C  \nATOM   3077  C   ARG A 392     -17.382  10.204  -4.365  1.00 96.58           C  \nATOM   3078  CB  ARG A 392     -16.204   8.346  -5.587  1.00 96.58           C  \nATOM   3079  O   ARG A 392     -18.593  10.376  -4.417  1.00 96.58           O  \nATOM   3080  CG  ARG A 392     -17.398   7.442  -5.262  1.00 96.58           C  \nATOM   3081  CD  ARG A 392     -16.968   6.000  -5.001  1.00 96.58           C  \nATOM   3082  NE  ARG A 392     -18.160   5.151  -4.868  1.00 96.58           N  \nATOM   3083  NH1 ARG A 392     -18.564   5.064  -7.100  1.00 96.58           N  \nATOM   3084  NH2 ARG A 392     -20.104   4.293  -5.731  1.00 96.58           N  \nATOM   3085  CZ  ARG A 392     -18.933   4.825  -5.882  1.00 96.58           C  \nATOM   3086  N   MET A 393     -16.678  10.328  -3.238  1.00 96.86           N  \nATOM   3087  CA  MET A 393     -17.297  10.677  -1.952  1.00 96.86           C  \nATOM   3088  C   MET A 393     -18.008  12.031  -2.019  1.00 96.86           C  \nATOM   3089  CB  MET A 393     -16.233  10.731  -0.851  1.00 96.86           C  \nATOM   3090  O   MET A 393     -19.142  12.168  -1.569  1.00 96.86           O  \nATOM   3091  CG  MET A 393     -15.652   9.361  -0.507  1.00 96.86           C  \nATOM   3092  SD  MET A 393     -14.265   9.454   0.656  1.00 96.86           S  \nATOM   3093  CE  MET A 393     -15.188   9.799   2.178  1.00 96.86           C  \nATOM   3094  N   ARG A 394     -17.366  13.030  -2.632  1.00 96.82           N  \nATOM   3095  CA  ARG A 394     -17.969  14.349  -2.844  1.00 96.82           C  \nATOM   3096  C   ARG A 394     -19.245  14.253  -3.686  1.00 96.82           C  \nATOM   3097  CB  ARG A 394     -16.921  15.259  -3.500  1.00 96.82           C  \nATOM   3098  O   ARG A 394     -20.254  14.871  -3.355  1.00 96.82           O  \nATOM   3099  CG  ARG A 394     -17.499  16.644  -3.798  1.00 96.82           C  \nATOM   3100  CD  ARG A 394     -16.545  17.487  -4.640  1.00 96.82           C  \nATOM   3101  NE  ARG A 394     -17.291  18.600  -5.247  1.00 96.82           N  \nATOM   3102  NH1 ARG A 394     -17.548  17.748  -7.372  1.00 96.82           N  \nATOM   3103  NH2 ARG A 394     -18.596  19.636  -6.760  1.00 96.82           N  \nATOM   3104  CZ  ARG A 394     -17.800  18.652  -6.461  1.00 96.82           C  \nATOM   3105  N   GLU A 395     -19.184  13.512  -4.791  1.00 95.18           N  \nATOM   3106  CA  GLU A 395     -20.299  13.333  -5.724  1.00 95.18           C  \nATOM   3107  C   GLU A 395     -21.468  12.584  -5.074  1.00 95.18           C  \nATOM   3108  CB  GLU A 395     -19.805  12.596  -6.984  1.00 95.18           C  \nATOM   3109  O   GLU A 395     -22.609  13.030  -5.196  1.00 95.18           O  \nATOM   3110  CG  GLU A 395     -18.950  13.494  -7.899  1.00 95.18           C  \nATOM   3111  CD  GLU A 395     -18.091  12.723  -8.922  1.00 95.18           C  \nATOM   3112  OE1 GLU A 395     -17.265  13.389  -9.592  1.00 95.18           O  \nATOM   3113  OE2 GLU A 395     -18.231  11.487  -9.059  1.00 95.18           O  \nATOM   3114  N   SER A 396     -21.202  11.506  -4.329  1.00 92.50           N  \nATOM   3115  CA  SER A 396     -22.244  10.727  -3.647  1.00 92.50           C  \nATOM   3116  C   SER A 396     -22.952  11.529  -2.554  1.00 92.50           C  \nATOM   3117  CB  SER A 396     -21.681   9.416  -3.083  1.00 92.50           C  \nATOM   3118  O   SER A 396     -24.162  11.390  -2.377  1.00 92.50           O  \nATOM   3119  OG  SER A 396     -20.777   9.613  -2.015  1.00 92.50           O  \nATOM   3120  N   ARG A 397     -22.230  12.431  -1.881  1.00 93.70           N  \nATOM   3121  CA  ARG A 397     -22.770  13.331  -0.849  1.00 93.70           C  \nATOM   3122  C   ARG A 397     -23.376  14.618  -1.398  1.00 93.70           C  \nATOM   3123  CB  ARG A 397     -21.673  13.633   0.171  1.00 93.70           C  \nATOM   3124  O   ARG A 397     -23.945  15.395  -0.637  1.00 93.70           O  \nATOM   3125  CG  ARG A 397     -21.259  12.356   0.904  1.00 93.70           C  \nATOM   3126  CD  ARG A 397     -20.071  12.671   1.793  1.00 93.70           C  \nATOM   3127  NE  ARG A 397     -19.587  11.441   2.426  1.00 93.70           N  \nATOM   3128  NH1 ARG A 397     -17.913  12.459   3.596  1.00 93.70           N  \nATOM   3129  NH2 ARG A 397     -18.142  10.259   3.718  1.00 93.70           N  \nATOM   3130  CZ  ARG A 397     -18.555  11.388   3.231  1.00 93.70           C  \nATOM   3131  N   SER A 398     -23.291  14.844  -2.712  1.00 93.17           N  \nATOM   3132  CA  SER A 398     -23.761  16.074  -3.365  1.00 93.17           C  \nATOM   3133  C   SER A 398     -23.169  17.349  -2.744  1.00 93.17           C  \nATOM   3134  CB  SER A 398     -25.294  16.109  -3.417  1.00 93.17           C  \nATOM   3135  O   SER A 398     -23.855  18.362  -2.603  1.00 93.17           O  \nATOM   3136  OG  SER A 398     -25.784  14.977  -4.113  1.00 93.17           O  \nATOM   3137  N   GLU A 399     -21.892  17.303  -2.360  1.00 92.50           N  \nATOM   3138  CA  GLU A 399     -21.207  18.432  -1.730  1.00 92.50           C  \nATOM   3139  C   GLU A 399     -20.519  19.328  -2.770  1.00 92.50           C  \nATOM   3140  CB  GLU A 399     -20.208  17.947  -0.670  1.00 92.50           C  \nATOM   3141  O   GLU A 399     -19.718  18.879  -3.596  1.00 92.50           O  \nATOM   3142  CG  GLU A 399     -20.916  17.390   0.578  1.00 92.50           C  \nATOM   3143  CD  GLU A 399     -19.939  16.929   1.672  1.00 92.50           C  \nATOM   3144  OE1 GLU A 399     -20.399  16.285   2.642  1.00 92.50           O  \nATOM   3145  OE2 GLU A 399     -18.733  17.233   1.553  1.00 92.50           O  \nATOM   3146  N   ASP A 400     -20.780  20.636  -2.709  1.00 92.82           N  \nATOM   3147  CA  ASP A 400     -20.091  21.602  -3.570  1.00 92.82           C  \nATOM   3148  C   ASP A 400     -18.598  21.674  -3.233  1.00 92.82           C  \nATOM   3149  CB  ASP A 400     -20.731  22.992  -3.445  1.00 92.82           C  \nATOM   3150  O   ASP A 400     -17.759  21.562  -4.133  1.00 92.82           O  \nATOM   3151  CG  ASP A 400     -22.056  23.126  -4.198  1.00 92.82           C  \nATOM   3152  OD1 ASP A 400     -22.203  22.466  -5.251  1.00 92.82           O  \nATOM   3153  OD2 ASP A 400     -22.873  23.962  -3.752  1.00 92.82           O  \nATOM   3154  N   VAL A 401     -18.286  21.803  -1.938  1.00 94.77           N  \nATOM   3155  CA  VAL A 401     -16.934  21.766  -1.370  1.00 94.77           C  \nATOM   3156  C   VAL A 401     -16.911  20.767  -0.220  1.00 94.77           C  \nATOM   3157  CB  VAL A 401     -16.463  23.152  -0.882  1.00 94.77           C  \nATOM   3158  O   VAL A 401     -17.601  20.978   0.776  1.00 94.77           O  \nATOM   3159  CG1 VAL A 401     -15.048  23.087  -0.285  1.00 94.77           C  \nATOM   3160  CG2 VAL A 401     -16.439  24.170  -2.030  1.00 94.77           C  \nATOM   3161  N   MET A 402     -16.094  19.722  -0.345  1.00 96.08           N  \nATOM   3162  CA  MET A 402     -15.943  18.694   0.689  1.00 96.08           C  \nATOM   3163  C   MET A 402     -14.693  18.952   1.530  1.00 96.08           C  \nATOM   3164  CB  MET A 402     -15.939  17.298   0.049  1.00 96.08           C  \nATOM   3165  O   MET A 402     -13.603  19.158   0.990  1.00 96.08           O  \nATOM   3166  CG  MET A 402     -15.830  16.175   1.090  1.00 96.08           C  \nATOM   3167  SD  MET A 402     -16.066  14.506   0.424  1.00 96.08           S  \nATOM   3168  CE  MET A 402     -14.486  14.324  -0.423  1.00 96.08           C  \nATOM   3169  N   ARG A 403     -14.841  18.915   2.855  1.00 97.26           N  \nATOM   3170  CA  ARG A 403     -13.721  18.904   3.805  1.00 97.26           C  \nATOM   3171  C   ARG A 403     -13.480  17.480   4.249  1.00 97.26           C  \nATOM   3172  CB  ARG A 403     -14.018  19.781   5.022  1.00 97.26           C  \nATOM   3173  O   ARG A 403     -14.407  16.822   4.703  1.00 97.26           O  \nATOM   3174  CG  ARG A 403     -13.972  21.250   4.627  1.00 97.26           C  \nATOM   3175  CD  ARG A 403     -14.235  22.142   5.829  1.00 97.26           C  \nATOM   3176  NE  ARG A 403     -13.964  23.523   5.437  1.00 97.26           N  \nATOM   3177  NH1 ARG A 403     -14.837  24.611   7.240  1.00 97.26           N  \nATOM   3178  NH2 ARG A 403     -13.980  25.755   5.491  1.00 97.26           N  \nATOM   3179  CZ  ARG A 403     -14.271  24.626   6.064  1.00 97.26           C  \nATOM   3180  N   ILE A 404     -12.250  17.008   4.106  1.00 97.41           N  \nATOM   3181  CA  ILE A 404     -11.933  15.626   4.440  1.00 97.41           C  \nATOM   3182  C   ILE A 404     -10.504  15.487   4.934  1.00 97.41           C  \nATOM   3183  CB  ILE A 404     -12.247  14.708   3.239  1.00 97.41           C  \nATOM   3184  O   ILE A 404      -9.586  16.166   4.465  1.00 97.41           O  \nATOM   3185  CG1 ILE A 404     -12.286  13.236   3.690  1.00 97.41           C  \nATOM   3186  CG2 ILE A 404     -11.278  14.926   2.060  1.00 97.41           C  \nATOM   3187  CD1 ILE A 404     -12.971  12.330   2.668  1.00 97.41           C  \nATOM   3188  N   THR A 405     -10.319  14.548   5.851  1.00 98.13           N  \nATOM   3189  CA  THR A 405      -9.004  14.127   6.307  1.00 98.13           C  \nATOM   3190  C   THR A 405      -8.695  12.723   5.795  1.00 98.13           C  \nATOM   3191  CB  THR A 405      -8.869  14.311   7.822  1.00 98.13           C  \nATOM   3192  O   THR A 405      -9.552  11.838   5.757  1.00 98.13           O  \nATOM   3193  CG2 THR A 405      -7.534  13.815   8.359  1.00 98.13           C  \nATOM   3194  OG1 THR A 405      -8.946  15.690   8.085  1.00 98.13           O  \nATOM   3195  N   VAL A 406      -7.450  12.526   5.371  1.00 98.51           N  \nATOM   3196  CA  VAL A 406      -6.920  11.247   4.902  1.00 98.51           C  \nATOM   3197  C   VAL A 406      -5.826  10.803   5.865  1.00 98.51           C  \nATOM   3198  CB  VAL A 406      -6.395  11.356   3.459  1.00 98.51           C  \nATOM   3199  O   VAL A 406      -4.773  11.442   5.959  1.00 98.51           O  \nATOM   3200  CG1 VAL A 406      -5.929   9.990   2.944  1.00 98.51           C  \nATOM   3201  CG2 VAL A 406      -7.447  11.900   2.483  1.00 98.51           C  \nATOM   3202  N   GLY A 407      -6.071   9.704   6.570  1.00 97.72           N  \nATOM   3203  CA  GLY A 407      -5.066   9.021   7.375  1.00 97.72           C  \nATOM   3204  C   GLY A 407      -4.169   8.178   6.476  1.00 97.72           C  \nATOM   3205  O   GLY A 407      -4.665   7.344   5.721  1.00 97.72           O  \nATOM   3206  N   VAL A 408      -2.854   8.381   6.537  1.00 97.79           N  \nATOM   3207  CA  VAL A 408      -1.888   7.671   5.691  1.00 97.79           C  \nATOM   3208  C   VAL A 408      -0.822   6.994   6.545  1.00 97.79           C  \nATOM   3209  CB  VAL A 408      -1.241   8.587   4.632  1.00 97.79           C  \nATOM   3210  O   VAL A 408      -0.188   7.622   7.394  1.00 97.79           O  \nATOM   3211  CG1 VAL A 408      -0.512   7.741   3.576  1.00 97.79           C  \nATOM   3212  CG2 VAL A 408      -2.245   9.474   3.882  1.00 97.79           C  \nATOM   3213  N   ASP A 409      -0.585   5.714   6.284  1.00 95.43           N  \nATOM   3214  CA  ASP A 409       0.547   4.948   6.805  1.00 95.43           C  \nATOM   3215  C   ASP A 409       1.335   4.315   5.640  1.00 95.43           C  \nATOM   3216  CB  ASP A 409       0.046   3.919   7.844  1.00 95.43           C  \nATOM   3217  O   ASP A 409       0.920   4.346   4.482  1.00 95.43           O  \nATOM   3218  CG  ASP A 409       1.108   3.476   8.863  1.00 95.43           C  \nATOM   3219  OD1 ASP A 409       2.321   3.682   8.613  1.00 95.43           O  \nATOM   3220  OD2 ASP A 409       0.739   2.972   9.941  1.00 95.43           O  \nATOM   3221  N   GLY A 410       2.493   3.736   5.934  1.00 93.71           N  \nATOM   3222  CA  GLY A 410       3.334   3.016   4.993  1.00 93.71           C  \nATOM   3223  C   GLY A 410       4.702   3.662   4.785  1.00 93.71           C  \nATOM   3224  O   GLY A 410       4.882   4.880   4.794  1.00 93.71           O  \nATOM   3225  N   SER A 411       5.705   2.807   4.600  1.00 93.45           N  \nATOM   3226  CA  SER A 411       7.112   3.201   4.516  1.00 93.45           C  \nATOM   3227  C   SER A 411       7.436   4.118   3.336  1.00 93.45           C  \nATOM   3228  CB  SER A 411       7.984   1.944   4.439  1.00 93.45           C  \nATOM   3229  O   SER A 411       8.307   4.970   3.476  1.00 93.45           O  \nATOM   3230  OG  SER A 411       7.527   1.082   3.409  1.00 93.45           O  \nATOM   3231  N   VAL A 412       6.754   3.991   2.193  1.00 96.83           N  \nATOM   3232  CA  VAL A 412       6.999   4.862   1.032  1.00 96.83           C  \nATOM   3233  C   VAL A 412       6.534   6.280   1.343  1.00 96.83           C  \nATOM   3234  CB  VAL A 412       6.334   4.312  -0.243  1.00 96.83           C  \nATOM   3235  O   VAL A 412       7.294   7.222   1.145  1.00 96.83           O  \nATOM   3236  CG1 VAL A 412       6.449   5.272  -1.432  1.00 96.83           C  \nATOM   3237  CG2 VAL A 412       6.963   2.976  -0.651  1.00 96.83           C  \nATOM   3238  N   TYR A 413       5.335   6.442   1.904  1.00 97.55           N  \nATOM   3239  CA  TYR A 413       4.828   7.761   2.284  1.00 97.55           C  \nATOM   3240  C   TYR A 413       5.661   8.428   3.385  1.00 97.55           C  \nATOM   3241  CB  TYR A 413       3.374   7.617   2.724  1.00 97.55           C  \nATOM   3242  O   TYR A 413       5.941   9.623   3.301  1.00 97.55           O  \nATOM   3243  CG  TYR A 413       2.723   8.918   3.123  1.00 97.55           C  \nATOM   3244  CD1 TYR A 413       2.639   9.280   4.481  1.00 97.55           C  \nATOM   3245  CD2 TYR A 413       2.170   9.746   2.129  1.00 97.55           C  \nATOM   3246  CE1 TYR A 413       1.964  10.454   4.853  1.00 97.55           C  \nATOM   3247  CE2 TYR A 413       1.496  10.923   2.498  1.00 97.55           C  \nATOM   3248  OH  TYR A 413       0.665  12.364   4.220  1.00 97.55           O  \nATOM   3249  CZ  TYR A 413       1.376  11.265   3.860  1.00 97.55           C  \nATOM   3250  N   LYS A 414       6.064   7.655   4.399  1.00 95.52           N  \nATOM   3251  CA  LYS A 414       6.765   8.170   5.584  1.00 95.52           C  \nATOM   3252  C   LYS A 414       8.254   8.423   5.366  1.00 95.52           C  \nATOM   3253  CB  LYS A 414       6.575   7.187   6.744  1.00 95.52           C  \nATOM   3254  O   LYS A 414       8.808   9.358   5.932  1.00 95.52           O  \nATOM   3255  CG  LYS A 414       5.117   7.124   7.211  1.00 95.52           C  \nATOM   3256  CD  LYS A 414       4.999   6.190   8.415  1.00 95.52           C  \nATOM   3257  CE  LYS A 414       3.686   6.452   9.140  1.00 95.52           C  \nATOM   3258  NZ  LYS A 414       3.470   5.453  10.201  1.00 95.52           N  \nATOM   3259  N   LEU A 415       8.925   7.561   4.598  1.00 95.41           N  \nATOM   3260  CA  LEU A 415      10.392   7.518   4.546  1.00 95.41           C  \nATOM   3261  C   LEU A 415      10.977   7.985   3.209  1.00 95.41           C  \nATOM   3262  CB  LEU A 415      10.902   6.103   4.889  1.00 95.41           C  \nATOM   3263  O   LEU A 415      12.178   8.243   3.141  1.00 95.41           O  \nATOM   3264  CG  LEU A 415      10.332   5.469   6.173  1.00 95.41           C  \nATOM   3265  CD1 LEU A 415      10.907   4.061   6.340  1.00 95.41           C  \nATOM   3266  CD2 LEU A 415      10.676   6.279   7.423  1.00 95.41           C  \nATOM   3267  N   HIS A 416      10.185   8.069   2.134  1.00 97.67           N  \nATOM   3268  CA  HIS A 416      10.684   8.593   0.863  1.00 97.67           C  \nATOM   3269  C   HIS A 416      10.718  10.131   0.896  1.00 97.67           C  \nATOM   3270  CB  HIS A 416       9.844   8.070  -0.302  1.00 97.67           C  \nATOM   3271  O   HIS A 416       9.685  10.749   1.166  1.00 97.67           O  \nATOM   3272  CG  HIS A 416      10.497   8.301  -1.637  1.00 97.67           C  \nATOM   3273  CD2 HIS A 416      11.195   7.367  -2.353  1.00 97.67           C  \nATOM   3274  ND1 HIS A 416      10.537   9.476  -2.360  1.00 97.67           N  \nATOM   3275  CE1 HIS A 416      11.237   9.248  -3.481  1.00 97.67           C  \nATOM   3276  NE2 HIS A 416      11.662   7.980  -3.512  1.00 97.67           N  \nATOM   3277  N   PRO A 417      11.852  10.780   0.567  1.00 97.21           N  \nATOM   3278  CA  PRO A 417      12.072  12.207   0.840  1.00 97.21           C  \nATOM   3279  C   PRO A 417      11.101  13.146   0.110  1.00 97.21           C  \nATOM   3280  CB  PRO A 417      13.519  12.470   0.396  1.00 97.21           C  \nATOM   3281  O   PRO A 417      10.757  14.207   0.617  1.00 97.21           O  \nATOM   3282  CG  PRO A 417      13.776  11.387  -0.652  1.00 97.21           C  \nATOM   3283  CD  PRO A 417      13.038  10.200  -0.049  1.00 97.21           C  \nATOM   3284  N   SER A 418      10.667  12.760  -1.088  1.00 96.74           N  \nATOM   3285  CA  SER A 418       9.920  13.611  -2.023  1.00 96.74           C  \nATOM   3286  C   SER A 418       8.529  13.069  -2.378  1.00 96.74           C  \nATOM   3287  CB  SER A 418      10.769  13.723  -3.292  1.00 96.74           C  \nATOM   3288  O   SER A 418       7.746  13.759  -3.032  1.00 96.74           O  \nATOM   3289  OG  SER A 418      10.969  12.401  -3.768  1.00 96.74           O  \nATOM   3290  N   PHE A 419       8.195  11.835  -1.969  1.00 98.45           N  \nATOM   3291  CA  PHE A 419       6.973  11.162  -2.431  1.00 98.45           C  \nATOM   3292  C   PHE A 419       5.731  11.884  -1.910  1.00 98.45           C  \nATOM   3293  CB  PHE A 419       6.971   9.689  -1.999  1.00 98.45           C  \nATOM   3294  O   PHE A 419       4.843  12.224  -2.687  1.00 98.45           O  \nATOM   3295  CG  PHE A 419       5.789   8.892  -2.515  1.00 98.45           C  \nATOM   3296  CD1 PHE A 419       4.542   8.963  -1.862  1.00 98.45           C  \nATOM   3297  CD2 PHE A 419       5.934   8.071  -3.650  1.00 98.45           C  \nATOM   3298  CE1 PHE A 419       3.441   8.247  -2.360  1.00 98.45           C  \nATOM   3299  CE2 PHE A 419       4.841   7.324  -4.122  1.00 98.45           C  \nATOM   3300  CZ  PHE A 419       3.593   7.417  -3.483  1.00 98.45           C  \nATOM   3301  N   LYS A 420       5.707  12.169  -0.602  1.00 97.84           N  \nATOM   3302  CA  LYS A 420       4.611  12.854   0.096  1.00 97.84           C  \nATOM   3303  C   LYS A 420       4.275  14.202  -0.544  1.00 97.84           C  \nATOM   3304  CB  LYS A 420       5.014  12.974   1.576  1.00 97.84           C  \nATOM   3305  O   LYS A 420       3.113  14.464  -0.836  1.00 97.84           O  \nATOM   3306  CG  LYS A 420       3.972  13.642   2.491  1.00 97.84           C  \nATOM   3307  CD  LYS A 420       4.410  13.453   3.956  1.00 97.84           C  \nATOM   3308  CE  LYS A 420       3.440  14.045   4.988  1.00 97.84           C  \nATOM   3309  NZ  LYS A 420       3.849  13.687   6.381  1.00 97.84           N  \nATOM   3310  N   GLU A 421       5.288  15.017  -0.837  1.00 98.17           N  \nATOM   3311  CA  GLU A 421       5.108  16.328  -1.472  1.00 98.17           C  \nATOM   3312  C   GLU A 421       4.501  16.207  -2.879  1.00 98.17           C  \nATOM   3313  CB  GLU A 421       6.461  17.053  -1.515  1.00 98.17           C  \nATOM   3314  O   GLU A 421       3.492  16.852  -3.176  1.00 98.17           O  \nATOM   3315  CG  GLU A 421       6.326  18.489  -2.046  1.00 98.17           C  \nATOM   3316  CD  GLU A 421       7.673  19.208  -2.216  1.00 98.17           C  \nATOM   3317  OE1 GLU A 421       7.643  20.326  -2.776  1.00 98.17           O  \nATOM   3318  OE2 GLU A 421       8.712  18.637  -1.816  1.00 98.17           O  \nATOM   3319  N   ARG A 422       5.074  15.343  -3.731  1.00 98.35           N  \nATOM   3320  CA  ARG A 422       4.594  15.114  -5.107  1.00 98.35           C  \nATOM   3321  C   ARG A 422       3.166  14.567  -5.117  1.00 98.35           C  \nATOM   3322  CB  ARG A 422       5.549  14.153  -5.838  1.00 98.35           C  \nATOM   3323  O   ARG A 422       2.323  15.048  -5.876  1.00 98.35           O  \nATOM   3324  CG  ARG A 422       6.938  14.762  -6.102  1.00 98.35           C  \nATOM   3325  CD  ARG A 422       7.885  13.697  -6.675  1.00 98.35           C  \nATOM   3326  NE  ARG A 422       9.277  14.183  -6.792  1.00 98.35           N  \nATOM   3327  NH1 ARG A 422      10.319  12.124  -6.780  1.00 98.35           N  \nATOM   3328  NH2 ARG A 422      11.558  13.921  -6.686  1.00 98.35           N  \nATOM   3329  CZ  ARG A 422      10.361  13.419  -6.768  1.00 98.35           C  \nATOM   3330  N   PHE A 423       2.888  13.609  -4.234  1.00 98.65           N  \nATOM   3331  CA  PHE A 423       1.570  13.018  -4.036  1.00 98.65           C  \nATOM   3332  C   PHE A 423       0.542  14.083  -3.630  1.00 98.65           C  \nATOM   3333  CB  PHE A 423       1.695  11.889  -3.005  1.00 98.65           C  \nATOM   3334  O   PHE A 423      -0.445  14.268  -4.338  1.00 98.65           O  \nATOM   3335  CG  PHE A 423       0.376  11.341  -2.507  1.00 98.65           C  \nATOM   3336  CD1 PHE A 423       0.013  11.522  -1.161  1.00 98.65           C  \nATOM   3337  CD2 PHE A 423      -0.484  10.649  -3.379  1.00 98.65           C  \nATOM   3338  CE1 PHE A 423      -1.208  11.017  -0.684  1.00 98.65           C  \nATOM   3339  CE2 PHE A 423      -1.702  10.137  -2.899  1.00 98.65           C  \nATOM   3340  CZ  PHE A 423      -2.057  10.315  -1.553  1.00 98.65           C  \nATOM   3341  N   HIS A 424       0.797  14.858  -2.568  1.00 98.52           N  \nATOM   3342  CA  HIS A 424      -0.119  15.910  -2.103  1.00 98.52           C  \nATOM   3343  C   HIS A 424      -0.375  16.977  -3.166  1.00 98.52           C  \nATOM   3344  CB  HIS A 424       0.456  16.605  -0.860  1.00 98.52           C  \nATOM   3345  O   HIS A 424      -1.518  17.389  -3.368  1.00 98.52           O  \nATOM   3346  CG  HIS A 424       0.505  15.794   0.405  1.00 98.52           C  \nATOM   3347  CD2 HIS A 424       0.042  14.524   0.588  1.00 98.52           C  \nATOM   3348  ND1 HIS A 424       0.957  16.295   1.626  1.00 98.52           N  \nATOM   3349  CE1 HIS A 424       0.778  15.303   2.510  1.00 98.52           C  \nATOM   3350  NE2 HIS A 424       0.245  14.225   1.915  1.00 98.52           N  \nATOM   3351  N   ALA A 425       0.675  17.437  -3.851  1.00 98.29           N  \nATOM   3352  CA  ALA A 425       0.545  18.443  -4.899  1.00 98.29           C  \nATOM   3353  C   ALA A 425      -0.334  17.947  -6.055  1.00 98.29           C  \nATOM   3354  CB  ALA A 425       1.947  18.827  -5.383  1.00 98.29           C  \nATOM   3355  O   ALA A 425      -1.141  18.712  -6.580  1.00 98.29           O  \nATOM   3356  N   SER A 426      -0.192  16.677  -6.439  1.00 98.47           N  \nATOM   3357  CA  SER A 426      -0.983  16.079  -7.511  1.00 98.47           C  \nATOM   3358  C   SER A 426      -2.439  15.839  -7.109  1.00 98.47           C  \nATOM   3359  CB  SER A 426      -0.292  14.808  -7.995  1.00 98.47           C  \nATOM   3360  O   SER A 426      -3.331  16.214  -7.866  1.00 98.47           O  \nATOM   3361  OG  SER A 426      -0.895  14.375  -9.190  1.00 98.47           O  \nATOM   3362  N   VAL A 427      -2.700  15.342  -5.891  1.00 98.58           N  \nATOM   3363  CA  VAL A 427      -4.074  15.172  -5.379  1.00 98.58           C  \nATOM   3364  C   VAL A 427      -4.827  16.502  -5.422  1.00 98.58           C  \nATOM   3365  CB  VAL A 427      -4.090  14.592  -3.951  1.00 98.58           C  \nATOM   3366  O   VAL A 427      -5.896  16.573  -6.017  1.00 98.58           O  \nATOM   3367  CG1 VAL A 427      -5.510  14.535  -3.378  1.00 98.58           C  \nATOM   3368  CG2 VAL A 427      -3.548  13.161  -3.906  1.00 98.58           C  \nATOM   3369  N   ARG A 428      -4.232  17.587  -4.902  1.00 97.99           N  \nATOM   3370  CA  ARG A 428      -4.873  18.916  -4.877  1.00 97.99           C  \nATOM   3371  C   ARG A 428      -5.260  19.436  -6.265  1.00 97.99           C  \nATOM   3372  CB  ARG A 428      -3.957  19.935  -4.188  1.00 97.99           C  \nATOM   3373  O   ARG A 428      -6.267  20.124  -6.386  1.00 97.99           O  \nATOM   3374  CG  ARG A 428      -3.847  19.702  -2.676  1.00 97.99           C  \nATOM   3375  CD  ARG A 428      -2.901  20.743  -2.067  1.00 97.99           C  \nATOM   3376  NE  ARG A 428      -2.589  20.428  -0.660  1.00 97.99           N  \nATOM   3377  NH1 ARG A 428      -0.290  20.333  -0.817  1.00 97.99           N  \nATOM   3378  NH2 ARG A 428      -1.291  19.869   1.120  1.00 97.99           N  \nATOM   3379  CZ  ARG A 428      -1.395  20.218  -0.131  1.00 97.99           C  \nATOM   3380  N   ARG A 429      -4.484  19.120  -7.309  1.00 97.99           N  \nATOM   3381  CA  ARG A 429      -4.830  19.494  -8.695  1.00 97.99           C  \nATOM   3382  C   ARG A 429      -6.012  18.688  -9.236  1.00 97.99           C  \nATOM   3383  CB  ARG A 429      -3.623  19.324  -9.628  1.00 97.99           C  \nATOM   3384  O   ARG A 429      -6.802  19.220 -10.007  1.00 97.99           O  \nATOM   3385  CG  ARG A 429      -2.515  20.355  -9.371  1.00 97.99           C  \nATOM   3386  CD  ARG A 429      -1.435  20.292 -10.460  1.00 97.99           C  \nATOM   3387  NE  ARG A 429      -0.795  18.963 -10.559  1.00 97.99           N  \nATOM   3388  NH1 ARG A 429       0.907  19.262  -9.046  1.00 97.99           N  \nATOM   3389  NH2 ARG A 429       0.760  17.341 -10.170  1.00 97.99           N  \nATOM   3390  CZ  ARG A 429       0.284  18.532  -9.929  1.00 97.99           C  \nATOM   3391  N   LEU A 430      -6.130  17.423  -8.837  1.00 98.58           N  \nATOM   3392  CA  LEU A 430      -7.182  16.509  -9.292  1.00 98.58           C  \nATOM   3393  C   LEU A 430      -8.491  16.639  -8.492  1.00 98.58           C  \nATOM   3394  CB  LEU A 430      -6.631  15.073  -9.252  1.00 98.58           C  \nATOM   3395  O   LEU A 430      -9.535  16.182  -8.957  1.00 98.58           O  \nATOM   3396  CG  LEU A 430      -5.439  14.806 -10.190  1.00 98.58           C  \nATOM   3397  CD1 LEU A 430      -4.883  13.409  -9.921  1.00 98.58           C  \nATOM   3398  CD2 LEU A 430      -5.830  14.895 -11.668  1.00 98.58           C  \nATOM   3399  N   THR A 431      -8.458  17.288  -7.325  1.00 98.02           N  \nATOM   3400  CA  THR A 431      -9.617  17.496  -6.438  1.00 98.02           C  \nATOM   3401  C   THR A 431      -9.827  18.985  -6.095  1.00 98.02           C  \nATOM   3402  CB  THR A 431      -9.473  16.649  -5.161  1.00 98.02           C  \nATOM   3403  O   THR A 431      -9.805  19.354  -4.918  1.00 98.02           O  \nATOM   3404  CG2 THR A 431      -9.295  15.157  -5.430  1.00 98.02           C  \nATOM   3405  OG1 THR A 431      -8.355  17.099  -4.429  1.00 98.02           O  \nATOM   3406  N   PRO A 432     -10.027  19.886  -7.079  1.00 96.88           N  \nATOM   3407  CA  PRO A 432     -10.092  21.336  -6.839  1.00 96.88           C  \nATOM   3408  C   PRO A 432     -11.274  21.777  -5.957  1.00 96.88           C  \nATOM   3409  CB  PRO A 432     -10.185  21.961  -8.235  1.00 96.88           C  \nATOM   3410  O   PRO A 432     -11.250  22.870  -5.398  1.00 96.88           O  \nATOM   3411  CG  PRO A 432     -10.848  20.868  -9.073  1.00 96.88           C  \nATOM   3412  CD  PRO A 432     -10.242  19.595  -8.489  1.00 96.88           C  \nATOM   3413  N   SER A 433     -12.298  20.933  -5.828  1.00 96.98           N  \nATOM   3414  CA  SER A 433     -13.488  21.160  -4.999  1.00 96.98           C  \nATOM   3415  C   SER A 433     -13.397  20.494  -3.620  1.00 96.98           C  \nATOM   3416  CB  SER A 433     -14.734  20.685  -5.753  1.00 96.98           C  \nATOM   3417  O   SER A 433     -14.423  20.276  -2.983  1.00 96.98           O  \nATOM   3418  OG  SER A 433     -14.870  21.380  -6.980  1.00 96.98           O  \nATOM   3419  N   CYS A 434     -12.200  20.110  -3.167  1.00 97.41           N  \nATOM   3420  CA  CYS A 434     -12.003  19.455  -1.874  1.00 97.41           C  \nATOM   3421  C   CYS A 434     -10.891  20.134  -1.065  1.00 97.41           C  \nATOM   3422  CB  CYS A 434     -11.706  17.962  -2.076  1.00 97.41           C  \nATOM   3423  O   CYS A 434      -9.795  20.383  -1.569  1.00 97.41           O  \nATOM   3424  SG  CYS A 434     -13.060  17.145  -2.970  1.00 97.41           S  \nATOM   3425  N   GLU A 435     -11.153  20.377   0.216  1.00 97.22           N  \nATOM   3426  CA  GLU A 435     -10.158  20.795   1.202  1.00 97.22           C  \nATOM   3427  C   GLU A 435      -9.650  19.543   1.931  1.00 97.22           C  \nATOM   3428  CB  GLU A 435     -10.769  21.809   2.181  1.00 97.22           C  \nATOM   3429  O   GLU A 435     -10.371  18.948   2.732  1.00 97.22           O  \nATOM   3430  CG  GLU A 435     -11.081  23.181   1.555  1.00 97.22           C  \nATOM   3431  CD  GLU A 435     -11.714  24.185   2.545  1.00 97.22           C  \nATOM   3432  OE1 GLU A 435     -12.108  25.291   2.115  1.00 97.22           O  \nATOM   3433  OE2 GLU A 435     -11.842  23.891   3.756  1.00 97.22           O  \nATOM   3434  N   ILE A 436      -8.420  19.123   1.616  1.00 98.10           N  \nATOM   3435  CA  ILE A 436      -7.862  17.846   2.082  1.00 98.10           C  \nATOM   3436  C   ILE A 436      -6.751  18.077   3.105  1.00 98.10           C  \nATOM   3437  CB  ILE A 436      -7.371  16.966   0.913  1.00 98.10           C  \nATOM   3438  O   ILE A 436      -5.720  18.687   2.791  1.00 98.10           O  \nATOM   3439  CG1 ILE A 436      -8.491  16.740  -0.127  1.00 98.10           C  \nATOM   3440  CG2 ILE A 436      -6.879  15.607   1.458  1.00 98.10           C  \nATOM   3441  CD1 ILE A 436      -7.964  16.184  -1.448  1.00 98.10           C  \nATOM   3442  N   THR A 437      -6.931  17.498   4.288  1.00 98.17           N  \nATOM   3443  CA  THR A 437      -5.894  17.369   5.317  1.00 98.17           C  \nATOM   3444  C   THR A 437      -5.314  15.957   5.280  1.00 98.17           C  \nATOM   3445  CB  THR A 437      -6.462  17.704   6.700  1.00 98.17           C  \nATOM   3446  O   THR A 437      -6.042  14.978   5.155  1.00 98.17           O  \nATOM   3447  CG2 THR A 437      -5.429  17.603   7.823  1.00 98.17           C  \nATOM   3448  OG1 THR A 437      -6.920  19.035   6.703  1.00 98.17           O  \nATOM   3449  N   PHE A 438      -3.994  15.826   5.395  1.00 98.15           N  \nATOM   3450  CA  PHE A 438      -3.334  14.523   5.492  1.00 98.15           C  \nATOM   3451  C   PHE A 438      -2.746  14.347   6.886  1.00 98.15           C  \nATOM   3452  CB  PHE A 438      -2.246  14.387   4.426  1.00 98.15           C  \nATOM   3453  O   PHE A 438      -1.930  15.169   7.306  1.00 98.15           O  \nATOM   3454  CG  PHE A 438      -2.765  14.311   3.007  1.00 98.15           C  \nATOM   3455  CD1 PHE A 438      -3.146  13.068   2.472  1.00 98.15           C  \nATOM   3456  CD2 PHE A 438      -2.851  15.471   2.214  1.00 98.15           C  \nATOM   3457  CE1 PHE A 438      -3.602  12.983   1.148  1.00 98.15           C  \nATOM   3458  CE2 PHE A 438      -3.306  15.385   0.886  1.00 98.15           C  \nATOM   3459  CZ  PHE A 438      -3.677  14.139   0.352  1.00 98.15           C  \nATOM   3460  N   ILE A 439      -3.106  13.256   7.557  1.00 95.95           N  \nATOM   3461  CA  ILE A 439      -2.537  12.869   8.850  1.00 95.95           C  \nATOM   3462  C   ILE A 439      -1.671  11.637   8.637  1.00 95.95           C  \nATOM   3463  CB  ILE A 439      -3.628  12.671   9.924  1.00 95.95           C  \nATOM   3464  O   ILE A 439      -2.076  10.665   8.004  1.00 95.95           O  \nATOM   3465  CG1 ILE A 439      -4.355  14.016  10.145  1.00 95.95           C  \nATOM   3466  CG2 ILE A 439      -3.009  12.162  11.241  1.00 95.95           C  \nATOM   3467  CD1 ILE A 439      -5.454  13.967  11.209  1.00 95.95           C  \nATOM   3468  N   GLU A 440      -0.445  11.694   9.137  1.00 95.20           N  \nATOM   3469  CA  GLU A 440       0.439  10.539   9.153  1.00 95.20           C  \nATOM   3470  C   GLU A 440       0.131   9.697  10.389  1.00 95.20           C  \nATOM   3471  CB  GLU A 440       1.880  11.037   9.109  1.00 95.20           C  \nATOM   3472  O   GLU A 440       0.173  10.201  11.505  1.00 95.20           O  \nATOM   3473  CG  GLU A 440       2.869   9.885   8.947  1.00 95.20           C  \nATOM   3474  CD  GLU A 440       4.284  10.413   8.696  1.00 95.20           C  \nATOM   3475  OE1 GLU A 440       5.218   9.811   9.268  1.00 95.20           O  \nATOM   3476  OE2 GLU A 440       4.415  11.358   7.865  1.00 95.20           O  \nATOM   3477  N   SER A 441      -0.213   8.428  10.194  1.00 90.21           N  \nATOM   3478  CA  SER A 441      -0.672   7.577  11.290  1.00 90.21           C  \nATOM   3479  C   SER A 441       0.495   7.055  12.127  1.00 90.21           C  \nATOM   3480  CB  SER A 441      -1.475   6.420  10.707  1.00 90.21           C  \nATOM   3481  O   SER A 441       1.377   6.383  11.594  1.00 90.21           O  \nATOM   3482  OG  SER A 441      -2.319   5.886  11.696  1.00 90.21           O  \nATOM   3483  N   GLU A 442       0.517   7.298  13.436  1.00 83.01           N  \nATOM   3484  CA  GLU A 442       1.490   6.680  14.345  1.00 83.01           C  \nATOM   3485  C   GLU A 442       0.958   5.336  14.864  1.00 83.01           C  \nATOM   3486  CB  GLU A 442       1.862   7.624  15.495  1.00 83.01           C  \nATOM   3487  O   GLU A 442      -0.054   5.276  15.557  1.00 83.01           O  \nATOM   3488  CG  GLU A 442       2.634   8.860  15.001  1.00 83.01           C  \nATOM   3489  CD  GLU A 442       3.233   9.702  16.142  1.00 83.01           C  \nATOM   3490  OE1 GLU A 442       3.965  10.665  15.817  1.00 83.01           O  \nATOM   3491  OE2 GLU A 442       3.025   9.349  17.326  1.00 83.01           O  \nATOM   3492  N   GLU A 443       1.633   4.235  14.510  1.00 77.64           N  \nATOM   3493  CA  GLU A 443       1.215   2.866  14.862  1.00 77.64           C  \nATOM   3494  C   GLU A 443      -0.220   2.497  14.416  1.00 77.64           C  \nATOM   3495  CB  GLU A 443       1.459   2.564  16.358  1.00 77.64           C  \nATOM   3496  O   GLU A 443      -0.873   1.650  15.036  1.00 77.64           O  \nATOM   3497  CG  GLU A 443       2.886   2.866  16.842  1.00 77.64           C  \nATOM   3498  CD  GLU A 443       3.132   2.449  18.306  1.00 77.64           C  \nATOM   3499  OE1 GLU A 443       4.315   2.248  18.652  1.00 77.64           O  \nATOM   3500  OE2 GLU A 443       2.170   2.219  19.077  1.00 77.64           O  \nATOM   3501  N   GLY A 444      -0.684   3.095  13.312  1.00 80.51           N  \nATOM   3502  CA  GLY A 444      -2.086   3.126  12.892  1.00 80.51           C  \nATOM   3503  C   GLY A 444      -2.797   1.784  12.849  1.00 80.51           C  \nATOM   3504  O   GLY A 444      -3.886   1.643  13.401  1.00 80.51           O  \nATOM   3505  N   SER A 445      -2.167   0.773  12.251  1.00 84.98           N  \nATOM   3506  CA  SER A 445      -2.765  -0.558  12.108  1.00 84.98           C  \nATOM   3507  C   SER A 445      -3.056  -1.238  13.450  1.00 84.98           C  \nATOM   3508  CB  SER A 445      -1.884  -1.455  11.235  1.00 84.98           C  \nATOM   3509  O   SER A 445      -4.115  -1.835  13.626  1.00 84.98           O  \nATOM   3510  OG  SER A 445      -0.534  -1.336  11.609  1.00 84.98           O  \nATOM   3511  N   GLY A 446      -2.156  -1.139  14.428  1.00 87.43           N  \nATOM   3512  CA  GLY A 446      -2.364  -1.760  15.735  1.00 87.43           C  \nATOM   3513  C   GLY A 446      -3.289  -0.949  16.641  1.00 87.43           C  \nATOM   3514  O   GLY A 446      -4.148  -1.522  17.317  1.00 87.43           O  \nATOM   3515  N   ARG A 447      -3.155   0.382  16.641  1.00 89.93           N  \nATOM   3516  CA  ARG A 447      -4.031   1.277  17.411  1.00 89.93           C  \nATOM   3517  C   ARG A 447      -5.467   1.242  16.892  1.00 89.93           C  \nATOM   3518  CB  ARG A 447      -3.430   2.689  17.374  1.00 89.93           C  \nATOM   3519  O   ARG A 447      -6.401   1.127  17.682  1.00 89.93           O  \nATOM   3520  CG  ARG A 447      -4.282   3.713  18.135  1.00 89.93           C  \nATOM   3521  CD  ARG A 447      -3.481   5.007  18.298  1.00 89.93           C  \nATOM   3522  NE  ARG A 447      -4.262   6.100  18.911  1.00 89.93           N  \nATOM   3523  NH1 ARG A 447      -2.985   7.815  18.056  1.00 89.93           N  \nATOM   3524  NH2 ARG A 447      -4.706   8.300  19.337  1.00 89.93           N  \nATOM   3525  CZ  ARG A 447      -3.985   7.387  18.769  1.00 89.93           C  \nATOM   3526  N   GLY A 448      -5.636   1.270  15.574  1.00 91.59           N  \nATOM   3527  CA  GLY A 448      -6.929   1.206  14.907  1.00 91.59           C  \nATOM   3528  C   GLY A 448      -7.703  -0.069  15.209  1.00 91.59           C  \nATOM   3529  O   GLY A 448      -8.854   0.016  15.622  1.00 91.59           O  \nATOM   3530  N   ALA A 449      -7.074  -1.244  15.090  1.00 92.27           N  \nATOM   3531  CA  ALA A 449      -7.737  -2.505  15.432  1.00 92.27           C  \nATOM   3532  C   ALA A 449      -8.197  -2.554  16.892  1.00 92.27           C  \nATOM   3533  CB  ALA A 449      -6.811  -3.680  15.126  1.00 92.27           C  \nATOM   3534  O   ALA A 449      -9.303  -3.009  17.163  1.00 92.27           O  \nATOM   3535  N   ALA A 450      -7.390  -2.049  17.829  1.00 91.57           N  \nATOM   3536  CA  ALA A 450      -7.799  -1.970  19.228  1.00 91.57           C  \nATOM   3537  C   ALA A 450      -9.005  -1.038  19.435  1.00 91.57           C  \nATOM   3538  CB  ALA A 450      -6.604  -1.514  20.058  1.00 91.57           C  \nATOM   3539  O   ALA A 450      -9.919  -1.381  20.180  1.00 91.57           O  \nATOM   3540  N   LEU A 451      -9.039   0.112  18.757  1.00 91.10           N  \nATOM   3541  CA  LEU A 451     -10.175   1.036  18.810  1.00 91.10           C  \nATOM   3542  C   LEU A 451     -11.443   0.423  18.197  1.00 91.10           C  \nATOM   3543  CB  LEU A 451      -9.795   2.344  18.098  1.00 91.10           C  \nATOM   3544  O   LEU A 451     -12.519   0.559  18.774  1.00 91.10           O  \nATOM   3545  CG  LEU A 451      -8.789   3.226  18.859  1.00 91.10           C  \nATOM   3546  CD1 LEU A 451      -8.308   4.347  17.937  1.00 91.10           C  \nATOM   3547  CD2 LEU A 451      -9.402   3.857  20.111  1.00 91.10           C  \nATOM   3548  N   VAL A 452     -11.328  -0.303  17.080  1.00 91.67           N  \nATOM   3549  CA  VAL A 452     -12.460  -1.043  16.494  1.00 91.67           C  \nATOM   3550  C   VAL A 452     -12.971  -2.106  17.465  1.00 91.67           C  \nATOM   3551  CB  VAL A 452     -12.100  -1.669  15.133  1.00 91.67           C  \nATOM   3552  O   VAL A 452     -14.178  -2.190  17.687  1.00 91.67           O  \nATOM   3553  CG1 VAL A 452     -13.252  -2.521  14.583  1.00 91.67           C  \nATOM   3554  CG2 VAL A 452     -11.826  -0.575  14.095  1.00 91.67           C  \nATOM   3555  N   SER A 453     -12.075  -2.862  18.105  1.00 91.63           N  \nATOM   3556  CA  SER A 453     -12.443  -3.814  19.159  1.00 91.63           C  \nATOM   3557  C   SER A 453     -13.178  -3.136  20.311  1.00 91.63           C  \nATOM   3558  CB  SER A 453     -11.198  -4.505  19.715  1.00 91.63           C  \nATOM   3559  O   SER A 453     -14.174  -3.661  20.800  1.00 91.63           O  \nATOM   3560  OG  SER A 453     -10.627  -5.301  18.704  1.00 91.63           O  \nATOM   3561  N   ALA A 454     -12.734  -1.949  20.722  1.00 90.17           N  \nATOM   3562  CA  ALA A 454     -13.364  -1.199  21.798  1.00 90.17           C  \nATOM   3563  C   ALA A 454     -14.799  -0.767  21.441  1.00 90.17           C  \nATOM   3564  CB  ALA A 454     -12.437  -0.035  22.159  1.00 90.17           C  \nATOM   3565  O   ALA A 454     -15.720  -0.944  22.243  1.00 90.17           O  \nATOM   3566  N   VAL A 455     -15.013  -0.299  20.207  1.00 88.71           N  \nATOM   3567  CA  VAL A 455     -16.347   0.018  19.668  1.00 88.71           C  \nATOM   3568  C   VAL A 455     -17.226  -1.237  19.582  1.00 88.71           C  \nATOM   3569  CB  VAL A 455     -16.220   0.703  18.291  1.00 88.71           C  \nATOM   3570  O   VAL A 455     -18.390  -1.200  19.989  1.00 88.71           O  \nATOM   3571  CG1 VAL A 455     -17.576   0.916  17.602  1.00 88.71           C  \nATOM   3572  CG2 VAL A 455     -15.566   2.084  18.420  1.00 88.71           C  \nATOM   3573  N   ALA A 456     -16.682  -2.357  19.096  1.00 87.79           N  \nATOM   3574  CA  ALA A 456     -17.400  -3.628  18.984  1.00 87.79           C  \nATOM   3575  C   ALA A 456     -17.861  -4.143  20.358  1.00 87.79           C  \nATOM   3576  CB  ALA A 456     -16.499  -4.640  18.266  1.00 87.79           C  \nATOM   3577  O   ALA A 456     -19.041  -4.449  20.546  1.00 87.79           O  \nATOM   3578  N   CYS A 457     -16.964  -4.145  21.350  1.00 87.20           N  \nATOM   3579  CA  CYS A 457     -17.287  -4.522  22.725  1.00 87.20           C  \nATOM   3580  C   CYS A 457     -18.365  -3.612  23.330  1.00 87.20           C  \nATOM   3581  CB  CYS A 457     -16.013  -4.478  23.581  1.00 87.20           C  \nATOM   3582  O   CYS A 457     -19.307  -4.106  23.949  1.00 87.20           O  \nATOM   3583  SG  CYS A 457     -14.884  -5.830  23.141  1.00 87.20           S  \nATOM   3584  N   LYS A 458     -18.271  -2.291  23.127  1.00 84.51           N  \nATOM   3585  CA  LYS A 458     -19.266  -1.331  23.627  1.00 84.51           C  \nATOM   3586  C   LYS A 458     -20.657  -1.621  23.053  1.00 84.51           C  \nATOM   3587  CB  LYS A 458     -18.791   0.094  23.299  1.00 84.51           C  \nATOM   3588  O   LYS A 458     -21.623  -1.679  23.811  1.00 84.51           O  \nATOM   3589  CG  LYS A 458     -19.611   1.200  23.985  1.00 84.51           C  \nATOM   3590  CD  LYS A 458     -19.252   2.560  23.357  1.00 84.51           C  \nATOM   3591  CE  LYS A 458     -19.936   3.779  23.993  1.00 84.51           C  \nATOM   3592  NZ  LYS A 458     -19.628   5.015  23.221  1.00 84.51           N  \nATOM   3593  N   LYS A 459     -20.764  -1.859  21.740  1.00 82.08           N  \nATOM   3594  CA  LYS A 459     -22.039  -2.206  21.087  1.00 82.08           C  \nATOM   3595  C   LYS A 459     -22.616  -3.525  21.591  1.00 82.08           C  \nATOM   3596  CB  LYS A 459     -21.868  -2.276  19.567  1.00 82.08           C  \nATOM   3597  O   LYS A 459     -23.809  -3.584  21.877  1.00 82.08           O  \nATOM   3598  CG  LYS A 459     -21.756  -0.883  18.942  1.00 82.08           C  \nATOM   3599  CD  LYS A 459     -21.750  -1.010  17.418  1.00 82.08           C  \nATOM   3600  CE  LYS A 459     -21.624   0.379  16.798  1.00 82.08           C  \nATOM   3601  NZ  LYS A 459     -21.627   0.312  15.320  1.00 82.08           N  \nATOM   3602  N   ALA A 460     -21.784  -4.555  21.745  1.00 82.22           N  \nATOM   3603  CA  ALA A 460     -22.218  -5.837  22.295  1.00 82.22           C  \nATOM   3604  C   ALA A 460     -22.782  -5.684  23.720  1.00 82.22           C  \nATOM   3605  CB  ALA A 460     -21.036  -6.811  22.245  1.00 82.22           C  \nATOM   3606  O   ALA A 460     -23.827  -6.250  24.036  1.00 82.22           O  \nATOM   3607  N   CYS A 461     -22.149  -4.851  24.555  1.00 79.15           N  \nATOM   3608  CA  CYS A 461     -22.652  -4.526  25.891  1.00 79.15           C  \nATOM   3609  C   CYS A 461     -23.994  -3.777  25.867  1.00 79.15           C  \nATOM   3610  CB  CYS A 461     -21.598  -3.700  26.640  1.00 79.15           C  \nATOM   3611  O   CYS A 461     -24.814  -4.020  26.745  1.00 79.15           O  \nATOM   3612  SG  CYS A 461     -20.197  -4.751  27.118  1.00 79.15           S  \nATOM   3613  N   MET A 462     -24.232  -2.889  24.893  1.00 75.71           N  \nATOM   3614  CA  MET A 462     -25.513  -2.175  24.769  1.00 75.71           C  \nATOM   3615  C   MET A 462     -26.651  -3.072  24.271  1.00 75.71           C  \nATOM   3616  CB  MET A 462     -25.396  -0.979  23.817  1.00 75.71           C  \nATOM   3617  O   MET A 462     -27.776  -2.903  24.712  1.00 75.71           O  \nATOM   3618  CG  MET A 462     -24.501   0.146  24.332  1.00 75.71           C  \nATOM   3619  SD  MET A 462     -24.649   1.631  23.303  1.00 75.71           S  \nATOM   3620  CE  MET A 462     -23.136   2.505  23.741  1.00 75.71           C  \nATOM   3621  N   LEU A 463     -26.373  -4.009  23.358  1.00 73.26           N  \nATOM   3622  CA  LEU A 463     -27.381  -4.937  22.823  1.00 73.26           C  \nATOM   3623  C   LEU A 463     -27.736  -6.072  23.796  1.00 73.26           C  \nATOM   3624  CB  LEU A 463     -26.863  -5.528  21.499  1.00 73.26           C  \nATOM   3625  O   LEU A 463     -28.789  -6.689  23.659  1.00 73.26           O  \nATOM   3626  CG  LEU A 463     -26.836  -4.539  20.322  1.00 73.26           C  \nATOM   3627  CD1 LEU A 463     -26.060  -5.161  19.159  1.00 73.26           C  \nATOM   3628  CD2 LEU A 463     -28.243  -4.196  19.826  1.00 73.26           C  \nATOM   3629  N   GLY A 464     -26.842  -6.382  24.738  1.00 62.21           N  \nATOM   3630  CA  GLY A 464     -27.078  -7.371  25.791  1.00 62.21           C  \nATOM   3631  C   GLY A 464     -27.823  -6.834  27.021  1.00 62.21           C  \nATOM   3632  O   GLY A 464     -28.141  -7.631  27.906  1.00 62.21           O  \nATOM   3633  N   GLN A 465     -28.059  -5.519  27.098  1.00 42.57           N  \nATOM   3634  CA  GLN A 465     -28.887  -4.853  28.115  1.00 42.57           C  \nATOM   3635  C   GLN A 465     -30.327  -4.736  27.624  1.00 42.57           C  \nATOM   3636  CB  GLN A 465     -28.321  -3.456  28.420  1.00 42.57           C  \nATOM   3637  O   GLN A 465     -31.233  -4.931  28.469  1.00 42.57           O  \nATOM   3638  CG  GLN A 465     -27.037  -3.520  29.252  1.00 42.57           C  \nATOM   3639  CD  GLN A 465     -26.400  -2.153  29.511  1.00 42.57           C  \nATOM   3640  NE2 GLN A 465     -25.247  -2.123  30.145  1.00 42.57           N  \nATOM   3641  OE1 GLN A 465     -26.898  -1.082  29.204  1.00 42.57           O  \nATOM   3642  OXT GLN A 465     -30.476  -4.421  26.425  1.00 42.57           O  \nEND   "],"format":"pdb","keepH":false,"options":{"keepH":false}},{"method":"setStyle","style":{"cartoon":{"style":"rectangle","ribbon":false,"arrows":true,"tubes":false,"thickness":0.4,"opacity":1,"colorfunc":"function(atom) {\n    const residue_colors = [ '#8C94BF', '#5D6CAE', '#8C94BF', '#8C94BF', '#B3B7CF', '#8C94BF', '#8C94BF', '#8C94BF', '#D2D3DC', '#8C94BF', '#8C94BF', '#E2E2E2', '#8C94BF', '#B3B7CF', '#D2D3DC', '#D2B0B6', '#B3B7CF', '#8C94BF', '#D2B0B6', '#AB5468', '#8C94BF', '#8C94BF', '#8E063B', '#8C94BF', '#C18692', '#5D6CAE', '#B3B7CF', '#5D6CAE', '#B3B7CF', '#C18692', '#B3B7CF', '#8C94BF', '#8E063B', '#C18692', '#5D6CAE', '#D2D3DC', '#8E063B', '#E2E2E2', '#8C94BF', '#8E063B', '#8E063B', '#8C94BF', '#D2D3DC', '#8E063B', '#8E063B', '#8C94BF', '#5D6CAE', '#8C94BF', '#D2D3DC', '#D2B0B6', '#8C94BF', '#8C94BF', '#8E063B', '#E2E2E2', '#8E063B', '#AB5468', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#E2E2E2', '#E2E2E2', '#DDD0D2', '#8E063B', '#8C94BF', '#8E063B', '#D2D3DC', '#8E063B', '#5D6CAE', '#8E063B', '#C18692', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#E2E2E2', '#8E063B', '#E2E2E2', '#8E063B', '#E2E2E2', '#8C94BF', '#8C94BF', '#5D6CAE', '#5D6CAE', '#8C94BF', '#5D6CAE', '#DDD0D2', '#5D6CAE', '#D2B0B6', '#8C94BF', '#E2E2E2', '#8C94BF', '#B3B7CF', '#D2D3DC', '#DDD0D2', '#8E063B', '#8C94BF', '#8E063B', '#AB5468', '#D2D3DC', '#D2D3DC', '#D2B0B6', '#AB5468', '#B3B7CF', '#8E063B', '#DDD0D2', '#8E063B', '#DDD0D2', '#DDD0D2', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#8E063B', '#8E063B', '#8C94BF', '#8E063B', '#8E063B', '#D2B0B6', '#D2D3DC', '#8E063B', '#8E063B', '#B3B7CF', '#B3B7CF', '#E2E2E2', '#8C94BF', '#C18692', '#C18692', '#5D6CAE', '#E2E2E2', '#E2E2E2', '#AB5468', '#AB5468', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#B3B7CF', '#AB5468', '#D2D3DC', '#E2E2E2', '#8E063B', '#AB5468', '#D2B0B6', '#8E063B', '#C18692', '#8E063B', '#AB5468', '#8C94BF', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#DDD0D2', '#8E063B', '#E2E2E2', '#AB5468', '#8E063B', '#D2B0B6', '#AB5468', '#B3B7CF', '#AB5468', '#8E063B', '#8E063B', '#D2D3DC', '#AB5468', '#8E063B', '#C18692', '#DDD0D2', '#8E063B', '#8E063B', '#D2D3DC', '#8E063B', '#8E063B', '#D2B0B6', '#C18692', '#8E063B', '#D2D3DC', '#8E063B', '#D2B0B6', '#8E063B', '#AB5468', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#C18692', '#C18692', '#E2E2E2', '#AB5468', '#8C94BF', '#8C94BF', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#E2E2E2', '#AB5468', '#5D6CAE', '#D2D3DC', '#8E063B', '#E2E2E2', '#E2E2E2', '#D2B0B6', '#8C94BF', '#C18692', '#8C94BF', '#8C94BF', '#8E063B', '#DDD0D2', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#8E063B', '#8E063B', '#D2B0B6', '#8C94BF', '#E2E2E2', '#D2B0B6', '#8E063B', '#B3B7CF', '#B3B7CF', '#8E063B', '#D2D3DC', '#E2E2E2', '#B3B7CF', '#AB5468', '#8E063B', '#B3B7CF', '#8C94BF', '#8E063B', '#8E063B', '#8C94BF', '#5D6CAE', '#8E063B', '#8C94BF', '#E2E2E2', '#D2D3DC', '#D2B0B6', '#B3B7CF', '#AB5468', '#E2E2E2', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#DDD0D2', '#8E063B', '#8E063B', '#DDD0D2', '#E2E2E2', '#8E063B', '#C18692', '#8C94BF', '#E2E2E2', '#B3B7CF', '#DDD0D2', '#8E063B', '#8E063B', '#5D6CAE', '#AB5468', '#8C94BF', '#D2D3DC', '#C18692', '#8C94BF', '#8C94BF', '#8E063B', '#B3B7CF', '#8C94BF', '#D2D3DC', '#D2B0B6', '#D2D3DC', '#8E063B', '#DDD0D2', '#8E063B', '#D2B0B6', '#AB5468', '#8E063B', '#8E063B', '#E2E2E2', '#8E063B', '#8E063B', '#E2E2E2', '#AB5468', '#5D6CAE', '#B3B7CF', '#E2E2E2', '#E2E2E2', '#E2E2E2', '#B3B7CF', '#AB5468', '#D2D3DC', '#B3B7CF', '#8E063B', '#8E063B', '#B3B7CF', '#5D6CAE', '#D2B0B6', '#D2B0B6', '#AB5468', '#8C94BF', '#AB5468', '#DDD0D2', '#5D6CAE', '#5D6CAE', '#8E063B', '#AB5468', '#D2D3DC', '#C18692', '#8E063B', '#E2E2E2', '#8C94BF', '#8E063B', '#8E063B', '#E2E2E2', '#B3B7CF', '#8E063B', '#8E063B', '#B3B7CF', '#8E063B', '#8E063B', '#8E063B', '#B3B7CF', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#D2D3DC', '#D2B0B6', '#8E063B', '#DDD0D2', '#8C94BF', '#B3B7CF', '#D2B0B6', '#5D6CAE', '#8C94BF', '#5D6CAE', '#5D6CAE', '#D2B0B6', '#8C94BF', '#AB5468', '#AB5468', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#D2D3DC', '#8E063B', '#8E063B', '#5D6CAE', '#8E063B', '#D2B0B6', '#B3B7CF', '#DDD0D2', '#8E063B', '#E2E2E2', '#5D6CAE', '#8C94BF', '#8E063B', '#8C94BF', '#8C94BF', '#8E063B', '#DDD0D2', '#D2D3DC', '#5D6CAE', '#AB5468', '#8C94BF', '#8E063B', '#8C94BF', '#8E063B', '#E2E2E2', '#B3B7CF', '#8E063B', '#E2E2E2', '#C18692', '#8E063B', '#8E063B', '#8E063B', '#C18692', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#C18692', '#B3B7CF', '#D2B0B6', '#B3B7CF', '#B3B7CF', '#5D6CAE', '#5D6CAE', '#5D6CAE', '#5D6CAE', '#5D6CAE' ];\n    return residue_colors[atom.resi];\n}"}},"sel":{}},{"method":"zoomTo"}]},"evals":[],"jsHooks":[]}</script><p>The image is interactive, including rotation and zoom. The following
@@ -184,29 +168,30 @@ <h3 id="uniprot-identifiers">UniProt identifiers<a class="anchor" aria-label="an
 with <code>P3555</code>; the choice of this identifier is so that
 results can be compared with Figure 3F of the <a href="https://www.science.org/doi/10.1126/science.adg7492" class="external-link">AlphaMissense</a>
 publication.</p>
-<div class="sourceCode" id="cb8"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb7"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">uniprot_ids</span> <span class="op">&lt;-</span></span>
 <span>    <span class="fu"><a href="../reference/AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"aa_substitutions"</span><span class="op">)</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">uniprot_id</span> <span class="op">%like%</span> <span class="st">"P3555%"</span><span class="op">)</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/distinct.html" class="external-link">distinct</a></span><span class="op">(</span><span class="va">uniprot_id</span><span class="op">)</span> <span class="op">|&gt;</span></span>
-<span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/pull.html" class="external-link">pull</a></span><span class="op">(</span><span class="va">uniprot_id</span><span class="op">)</span></span>
+<span>    <span class="fu">pull</span><span class="op">(</span><span class="va">uniprot_id</span><span class="op">)</span></span>
 <span><span class="va">uniprot_ids</span></span>
-<span><span class="co">#&gt; [1] "P35558" "P35557" "P35556" "P35555"</span></span></code></pre></div>
+<span><span class="co">#&gt; [1] "P35555" "P35556" "P35558" "P35557"</span></span></code></pre></div>
 <p>The <a href="https://mtmorgan.github.io/AlphaMissenseR">AlphaMissenseR</a>
 package includes several functions that facilitate interaction with <a href="https://alphafold.ebi.ac.uk/" class="external-link">AlphaFold</a>; these functions start
 with <code>af_*()</code>. Use <code><a href="../reference/AlphaFold.html">af_predictions()</a></code> to discover
 AlphaFold predictions (via the AlphaFold API) associated with UniProt
 identifiers.</p>
-<div class="sourceCode" id="cb9"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb8"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">prediction</span> <span class="op">&lt;-</span> <span class="fu"><a href="../reference/AlphaFold.html">af_predictions</a></span><span class="op">(</span><span class="va">uniprot_ids</span><span class="op">)</span></span>
-<span><span class="co">#&gt; * [14:05:13][info] 2 of 4 uniprot accessions not found</span></span>
-<span><span class="co">#&gt;   'P35556', 'P35555'</span></span></code></pre></div>
-<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r">
-<code class="sourceCode R"><span><span class="fu"><a href="https://pillar.r-lib.org/reference/glimpse.html" class="external-link">glimpse</a></span><span class="op">(</span><span class="va">prediction</span><span class="op">)</span></span>
+<span><span class="co">#&gt; * [11:38:42][info] 2 of 4 uniprot accessions not found</span></span>
+<span><span class="co">#&gt;   'P35555', 'P35556'</span></span>
+<span><span class="fu">glimpse</span><span class="op">(</span><span class="va">prediction</span><span class="op">)</span></span>
 <span><span class="co">#&gt; Rows: 2</span></span>
-<span><span class="co">#&gt; Columns: 23</span></span>
+<span><span class="co">#&gt; Columns: 25</span></span>
 <span><span class="co">#&gt; $ entryId                <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> "AF-P35558-F1", "AF-P35557-F1"</span></span>
 <span><span class="co">#&gt; $ gene                   <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> "PCK1", "GCK"</span></span>
+<span><span class="co">#&gt; $ sequenceChecksum       <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> "78D309E0845CC181", "094D4A2F78096724"</span></span>
+<span><span class="co">#&gt; $ sequenceVersionDate    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> "2006-03-07", "1994-06-01"</span></span>
 <span><span class="co">#&gt; $ uniprotAccession       <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> "P35558", "P35557"</span></span>
 <span><span class="co">#&gt; $ uniprotId              <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> "PCKGC_HUMAN", "HXK4_HUMAN"</span></span>
 <span><span class="co">#&gt; $ uniprotDescription     <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> "Phosphoenolpyruvate carboxykinase, cytosolic […</span></span>
@@ -239,14 +224,14 @@ <h3 id="uniprot-identifiers">UniProt identifiers<a class="anchor" aria-label="an
 <h3 id="protein-structure">Protein structure<a class="anchor" aria-label="anchor" href="#protein-structure"></a>
 </h3>
 <p>Focus on a particular UniProt identifier and the PDB url.</p>
-<div class="sourceCode" id="cb11"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb9"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">pdb_url</span> <span class="op">&lt;-</span></span>
 <span>    <span class="va">prediction</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">uniprotAccession</span> <span class="op">==</span> <span class="st">"P35557"</span><span class="op">)</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/pull.html" class="external-link">pull</a></span><span class="op">(</span><span class="va">pdbUrl</span><span class="op">)</span></span></code></pre></div>
 <p>Cache the PDB file using BiocFileCache, and read the PDB file using
 <a href="https://CRAN.R-project.org/package=bio3d" class="external-link">bio3d</a>.</p>
-<div class="sourceCode" id="cb12"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">pdb_file</span> <span class="op">&lt;-</span> <span class="fu">BiocFileCache</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/BiocFileCache/man/BiocFileCache-class.html" class="external-link">bfcrpath</a></span><span class="op">(</span>rnames <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/basename.html" class="external-link">basename</a></span><span class="op">(</span><span class="va">pdb_url</span><span class="op">)</span>, fpath <span class="op">=</span> <span class="va">pdb_url</span><span class="op">)</span></span>
 <span><span class="va">pdb</span> <span class="op">&lt;-</span> <span class="fu">bio3d</span><span class="fu">::</span><span class="fu"><a href="http://thegrantlab.org/bio3d/reference/read.pdb.html" class="external-link">read.pdb</a></span><span class="op">(</span><span class="va">pdb_file</span><span class="op">)</span></span>
 <span><span class="va">pdb</span></span>
@@ -271,7 +256,7 @@ <h3 id="protein-structure">Protein structure<a class="anchor" aria-label="anchor
 <span><span class="co">#&gt; + attr: atom, xyz, seqres, calpha, call</span></span></code></pre></div>
 <p>Visualize the protein using <a href="https://CRAN.R-project.org/package=r3dmol" class="external-link">r3dmol</a>, using the
 ‘cartoon’ style.</p>
-<div class="sourceCode" id="cb13"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb11"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu">r3dmol</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/r3dmol/man/init.html" class="external-link">r3dmol</a></span><span class="op">(</span><span class="op">)</span> <span class="op">|&gt;</span></span>
 <span>    <span class="co">## use the PDB representation</span></span>
 <span>    <span class="fu">r3dmol</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/r3dmol/man/add_model.html" class="external-link">m_add_model</a></span><span class="op">(</span><span class="fu">r3dmol</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/r3dmol/man/m_bio3d.html" class="external-link">m_bio3d</a></span><span class="op">(</span><span class="va">pdb</span><span class="op">)</span><span class="op">)</span> <span class="op">|&gt;</span></span>
@@ -289,7 +274,7 @@ <h3 id="average-pathogenicity">Average pathogenicity<a class="anchor" aria-label
 the three-dimensional protein structure provided by AlphaFold. Start
 with a specific genome sequence (e.g., <code>hg38</code>). Filter to the
 amino acids in our UniProt region of interest.</p>
-<div class="sourceCode" id="cb14"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb12"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">P35557</span> <span class="op">&lt;-</span></span>
 <span>    <span class="fu"><a href="../reference/AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"hg38"</span><span class="op">)</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">uniprot_id</span> <span class="op">==</span> <span class="st">"P35557"</span><span class="op">)</span></span></code></pre></div>
@@ -297,7 +282,7 @@ <h3 id="average-pathogenicity">Average pathogenicity<a class="anchor" aria-label
 several alternative alleles and hence protein variants. The (arithmetic)
 average pathogenicity (this is an extremely naive computation) at each
 amino acid position is</p>
-<div class="sourceCode" id="cb15"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb13"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">pathogenicity</span> <span class="op">&lt;-</span> <span class="fu"><a href="../reference/am_aa.html">am_aa_pathogenicity</a></span><span class="op">(</span><span class="va">P35557</span><span class="op">)</span></span>
 <span><span class="va">pathogenicity</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># A tibble: 464 × 9</span></span></span>
@@ -328,7 +313,7 @@ <h3 id="coloring-amino-acids-by-position">Coloring amino acids by position<a cla
 approach taken in <a href="https://mtmorgan.github.io/AlphaMissenseR">AlphaMissenseR</a> is
 to use a template, ultimately replacing <code>...</code> with a vector
 of residue colors.</p>
-<div class="sourceCode" id="cb16"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb14"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/base/cat.html" class="external-link">cat</a></span><span class="op">(</span></span>
 <span>    <span class="fu">AlphaMissenseR</span><span class="fu">:::</span><span class="fu">js_template</span><span class="op">(</span><span class="st">"colorfunc"</span>, colors <span class="op">=</span> <span class="st">"..."</span><span class="op">)</span>,</span>
 <span>    <span class="st">"\n"</span></span>
@@ -341,8 +326,8 @@ <h3 id="coloring-amino-acids-by-position">Coloring amino acids by position<a cla
 mechanism for translating a vector of scores between zero and one into a
 vector of colors. This is illustrated for a 12-amino acid sequence where
 the first and last residues are uncolored.</p>
-<div class="sourceCode" id="cb17"><pre class="downlit sourceCode r">
-<code class="sourceCode R"><span><span class="va">df</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://tibble.tidyverse.org/reference/tibble.html" class="external-link">tibble</a></span><span class="op">(</span></span>
+<div class="sourceCode" id="cb15"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="va">df</span> <span class="op">&lt;-</span> <span class="fu">tibble</span><span class="op">(</span></span>
 <span>    pos <span class="op">=</span> <span class="fl">1</span> <span class="op">+</span> <span class="fl">1</span><span class="op">:</span><span class="fl">10</span>, <span class="co"># no color information for position 1</span></span>
 <span>    value <span class="op">=</span> <span class="fl">10</span><span class="op">:</span><span class="fl">1</span> <span class="op">/</span> <span class="fl">10</span></span>
 <span><span class="op">)</span></span>
@@ -361,7 +346,7 @@ <h3 id="coloring-amino-acids-by-position">Coloring amino acids by position<a cla
 pathogenicity and scales the palette between the minimum and maximum
 values of the mean pathogenicity vector, rather than between 0 and
 1.</p>
-<div class="sourceCode" id="cb18"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb16"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">colorfunc</span> <span class="op">&lt;-</span></span>
 <span>    <span class="va">pathogenicity</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu"><a href="../reference/AlphaFold.html">af_colorfunc_by_position</a></span><span class="op">(</span></span>
@@ -370,7 +355,7 @@ <h3 id="coloring-amino-acids-by-position">Coloring amino acids by position<a cla
 <span>    <span class="op">)</span></span></code></pre></div>
 <p>Add this as the <code>colorfunc=</code> argument to
 <code>m_style_cartoon()</code> for visualization.</p>
-<div class="sourceCode" id="cb19"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb17"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu">r3dmol</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/r3dmol/man/init.html" class="external-link">r3dmol</a></span><span class="op">(</span><span class="op">)</span> <span class="op">|&gt;</span></span>
 <span>    <span class="co">## use the PDB representation</span></span>
 <span>    <span class="fu">r3dmol</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/r3dmol/man/add_model.html" class="external-link">m_add_model</a></span><span class="op">(</span><span class="fu">r3dmol</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/r3dmol/man/m_bio3d.html" class="external-link">m_bio3d</a></span><span class="op">(</span><span class="va">pdb</span><span class="op">)</span><span class="op">)</span> <span class="op">|&gt;</span></span>
@@ -389,11 +374,57 @@ <h3 id="coloring-amino-acids-by-position">Coloring amino acids by position<a cla
 </div>
 </div>
 <div class="section level2">
+<h2 id="visualizing-genomic-tracks">Visualizing genomic tracks<a class="anchor" aria-label="anchor" href="#visualizing-genomic-tracks"></a>
+</h2>
+<p>The variant effect prediction data can also be visualized in a genome
+browser view. This allows the user to explore the predicted
+pathogenicity of single nucleotide missense mutations in a gene of
+interest. This multi-scale visualization is based on <a href="https://gosling-lang.org/" class="external-link">Gosling</a>, a grammar-based toolkit
+for scalable and interactive genomics data visualization.</p>
+<p>For demonstration, we create a <code>GPos</code> object for a protein
+of interest.</p>
+<div class="sourceCode" id="cb18"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="va">gpos</span> <span class="op">&lt;-</span></span>
+<span>    <span class="fu"><a href="../reference/AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"hg38"</span><span class="op">)</span> <span class="op">|&gt;</span></span>
+<span>    <span class="fu"><a href="https://rdrr.io/r/stats/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">uniprot_id</span> <span class="op">==</span> <span class="st">"Q1W6H9"</span><span class="op">)</span> <span class="op">|&gt;</span></span>
+<span>    <span class="fu"><a href="../reference/GenomicRanges.html">to_GPos</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div>
+<p>The function <code>plot_granges</code> invokes functionality from the
+<a href="https://bioconductor.org/packages/shiny.gosling" class="external-link">shiny.gosling</a>
+package to produce an interactive genome track plot in which the
+pathogenicity score for each point mutation in a linear genomic
+track.</p>
+<p>The resulting plot is a <a href="https://shiny.posit.co/" class="external-link">Shiny</a>
+app that can be displayed when running the following command in an
+interactive R session.</p>
+<div class="sourceCode" id="cb19"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="fu"><a href="../reference/Gosling.html">gosling_plot</a></span><span class="op">(</span></span>
+<span>    <span class="va">gpos</span>, plot_type <span class="op">=</span> <span class="st">"bar"</span>,</span>
+<span>    title <span class="op">=</span> <span class="st">"Q1W6H9 track"</span>,</span>
+<span>    subtitle <span class="op">=</span> <span class="st">"bar plot example"</span></span>
+<span><span class="op">)</span></span></code></pre></div>
+<div class="float">
+<img src="images/gosling_bar.png" alt="Bar plot for Q1W6H9"><div class="figcaption">Bar plot for Q1W6H9</div>
+</div>
+<p>Alternatively, a multiscale-lollipop plot can be generated with the
+same function by changing the <code>plot_type</code> argument to
+highlight the predicted class outcomes for each mutation (ambigious,
+benign, pathogenic).</p>
+<div class="sourceCode" id="cb20"><pre class="downlit sourceCode r">
+<code class="sourceCode R"><span><span class="fu"><a href="../reference/Gosling.html">gosling_plot</a></span><span class="op">(</span></span>
+<span>    <span class="va">gpos</span>, plot_type <span class="op">=</span> <span class="st">"lollipop"</span>,</span>
+<span>    title <span class="op">=</span> <span class="st">"Q1W6H9 track"</span>,</span>
+<span>    subtitle <span class="op">=</span> <span class="st">"lollipop plot example"</span></span>
+<span><span class="op">)</span></span></code></pre></div>
+<div class="float">
+<img src="images/gosling_lollipop.png" alt="Lollipop plot for Q1W6H9"><div class="figcaption">Lollipop plot for Q1W6H9</div>
+</div>
+</div>
+<div class="section level2">
 <h2 id="finally">Finally<a class="anchor" aria-label="anchor" href="#finally"></a>
 </h2>
 <p>Remember to disconnect and shutdown all managed DuckDB
 connections.</p>
-<div class="sourceCode" id="cb20"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb21"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="../reference/db.html">db_disconnect_all</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div>
 <p>Database connections that are not closed correctly trigger warning
 messages.</p>
@@ -401,15 +432,15 @@ <h2 id="finally">Finally<a class="anchor" aria-label="anchor" href="#finally"></
 <div class="section level2">
 <h2 class="unnumbered" id="session-information">Session information<a class="anchor" aria-label="anchor" href="#session-information"></a>
 </h2>
-<div class="sourceCode" id="cb21"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb22"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/utils/sessionInfo.html" class="external-link">sessionInfo</a></span><span class="op">(</span><span class="op">)</span></span>
-<span><span class="co">#&gt; R version 4.4.1 Patched (2024-06-20 r86819)</span></span>
-<span><span class="co">#&gt; Platform: aarch64-apple-darwin23.5.0</span></span>
-<span><span class="co">#&gt; Running under: macOS Sonoma 14.5</span></span>
+<span><span class="co">#&gt; R Under development (unstable) (2024-07-31 r86945)</span></span>
+<span><span class="co">#&gt; Platform: aarch64-apple-darwin23.4.0</span></span>
+<span><span class="co">#&gt; Running under: macOS Sonoma 14.6.1</span></span>
 <span><span class="co">#&gt; </span></span>
 <span><span class="co">#&gt; Matrix products: default</span></span>
-<span><span class="co">#&gt; BLAS:   /Users/ma38727/bin/R-4-4-branch/lib/libRblas.dylib </span></span>
-<span><span class="co">#&gt; LAPACK: /Users/ma38727/bin/R-4-4-branch/lib/libRlapack.dylib;  LAPACK version 3.12.0</span></span>
+<span><span class="co">#&gt; BLAS:   /Users/mtmorgan/bin/R-devel/lib/libRblas.dylib </span></span>
+<span><span class="co">#&gt; LAPACK: /Users/mtmorgan/bin/R-devel/lib/libRlapack.dylib;  LAPACK version 3.12.0</span></span>
 <span><span class="co">#&gt; </span></span>
 <span><span class="co">#&gt; locale:</span></span>
 <span><span class="co">#&gt; [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8</span></span>
@@ -424,32 +455,36 @@ <h2 class="unnumbered" id="session-information">Session information<a class="anc
 <span><span class="co">#&gt; [1] AlphaMissenseR_1.1.5 dplyr_1.1.4         </span></span>
 <span><span class="co">#&gt; </span></span>
 <span><span class="co">#&gt; loaded via a namespace (and not attached):</span></span>
-<span><span class="co">#&gt;  [1] gtable_0.3.5         xfun_0.45            bslib_0.7.0         </span></span>
-<span><span class="co">#&gt;  [4] ggplot2_3.5.1        htmlwidgets_1.6.4    vctrs_0.6.5         </span></span>
-<span><span class="co">#&gt;  [7] rjsoncons_1.3.0      tools_4.4.1          generics_0.1.3      </span></span>
-<span><span class="co">#&gt; [10] curl_5.2.1           parallel_4.4.1       tibble_3.2.1        </span></span>
-<span><span class="co">#&gt; [13] fansi_1.0.6          RSQLite_2.3.7        blob_1.2.4          </span></span>
-<span><span class="co">#&gt; [16] pkgconfig_2.0.3      BiocBaseUtils_1.7.0  dbplyr_2.5.0        </span></span>
-<span><span class="co">#&gt; [19] desc_1.4.3           RcppSpdlog_0.0.17    lifecycle_1.0.4     </span></span>
-<span><span class="co">#&gt; [22] compiler_4.4.1       textshaping_0.4.0    munsell_0.5.1       </span></span>
-<span><span class="co">#&gt; [25] httpuv_1.6.15        htmltools_0.5.8.1    sass_0.4.9          </span></span>
-<span><span class="co">#&gt; [28] yaml_2.3.8           pillar_1.9.0         pkgdown_2.0.9       </span></span>
-<span><span class="co">#&gt; [31] later_1.3.2          jquerylib_0.1.4      whisker_0.4.1       </span></span>
-<span><span class="co">#&gt; [34] tidyr_1.3.1          cachem_1.1.0         mime_0.12           </span></span>
-<span><span class="co">#&gt; [37] tidyselect_1.2.1     r3dmol_0.1.2         digest_0.6.36       </span></span>
-<span><span class="co">#&gt; [40] duckdb_1.0.0         purrr_1.0.2          fastmap_1.2.0       </span></span>
-<span><span class="co">#&gt; [43] grid_4.4.1           colorspace_2.1-0     cli_3.6.3           </span></span>
-<span><span class="co">#&gt; [46] magrittr_2.0.3       spdl_0.0.5           utf8_1.2.4          </span></span>
-<span><span class="co">#&gt; [49] withr_3.0.0          promises_1.3.0       filelock_1.0.3      </span></span>
-<span><span class="co">#&gt; [52] scales_1.3.0         bit64_4.0.5          rmarkdown_2.27      </span></span>
-<span><span class="co">#&gt; [55] httr_1.4.7           bit_4.0.5            ragg_1.3.2          </span></span>
-<span><span class="co">#&gt; [58] memoise_2.0.1        shiny_1.8.1.1        evaluate_0.24.0     </span></span>
-<span><span class="co">#&gt; [61] knitr_1.47           bio3d_2.4-4          BiocFileCache_2.13.0</span></span>
-<span><span class="co">#&gt; [64] rlang_1.1.4          Rcpp_1.0.12          xtable_1.8-4        </span></span>
-<span><span class="co">#&gt; [67] glue_1.7.0           DBI_1.2.3            jsonlite_1.8.8      </span></span>
-<span><span class="co">#&gt; [70] R6_2.5.1             systemfonts_1.1.0    fs_1.6.4</span></span></code></pre></div>
+<span><span class="co">#&gt;  [1] gtable_0.3.5            xfun_0.47               bslib_0.8.0            </span></span>
+<span><span class="co">#&gt;  [4] ggplot2_3.5.1           htmlwidgets_1.6.4       vctrs_0.6.5            </span></span>
+<span><span class="co">#&gt;  [7] rjsoncons_1.3.1         tools_4.5.0             generics_0.1.3         </span></span>
+<span><span class="co">#&gt; [10] stats4_4.5.0            curl_5.2.3              parallel_4.5.0         </span></span>
+<span><span class="co">#&gt; [13] tibble_3.2.1            fansi_1.0.6             RSQLite_2.3.7          </span></span>
+<span><span class="co">#&gt; [16] blob_1.2.4              shiny.gosling_1.1.0     pkgconfig_2.0.3        </span></span>
+<span><span class="co">#&gt; [19] BiocBaseUtils_1.7.3     dbplyr_2.5.0            S4Vectors_0.43.2       </span></span>
+<span><span class="co">#&gt; [22] desc_1.4.3              RcppSpdlog_0.0.18       GenomeInfoDbData_1.2.12</span></span>
+<span><span class="co">#&gt; [25] lifecycle_1.0.4         compiler_4.5.0          textshaping_0.4.0      </span></span>
+<span><span class="co">#&gt; [28] munsell_0.5.1           GenomeInfoDb_1.41.1     httpuv_1.6.15          </span></span>
+<span><span class="co">#&gt; [31] htmltools_0.5.8.1       sass_0.4.9              yaml_2.3.10            </span></span>
+<span><span class="co">#&gt; [34] later_1.3.2             pillar_1.9.0            pkgdown_2.1.0          </span></span>
+<span><span class="co">#&gt; [37] jquerylib_0.1.4         whisker_0.4.1           tidyr_1.3.1            </span></span>
+<span><span class="co">#&gt; [40] cachem_1.1.0            mime_0.12               tidyselect_1.2.1       </span></span>
+<span><span class="co">#&gt; [43] r3dmol_0.1.2            digest_0.6.37           duckdb_1.0.0-2         </span></span>
+<span><span class="co">#&gt; [46] purrr_1.0.2             fastmap_1.2.0           grid_4.5.0             </span></span>
+<span><span class="co">#&gt; [49] colorspace_2.1-1        cli_3.6.3               magrittr_2.0.3         </span></span>
+<span><span class="co">#&gt; [52] spdl_0.0.5              utf8_1.2.4              withr_3.0.1            </span></span>
+<span><span class="co">#&gt; [55] UCSC.utils_1.1.0        promises_1.3.0          filelock_1.0.3         </span></span>
+<span><span class="co">#&gt; [58] scales_1.3.0            bit64_4.0.5             XVector_0.45.0         </span></span>
+<span><span class="co">#&gt; [61] rmarkdown_2.28          httr_1.4.7              bit_4.0.5              </span></span>
+<span><span class="co">#&gt; [64] ragg_1.3.2              memoise_2.0.1           shiny_1.9.1            </span></span>
+<span><span class="co">#&gt; [67] evaluate_0.24.0         knitr_1.48              IRanges_2.39.2         </span></span>
+<span><span class="co">#&gt; [70] GenomicRanges_1.57.1    bio3d_2.4-4             BiocFileCache_2.13.0   </span></span>
+<span><span class="co">#&gt; [73] rlang_1.1.4             Rcpp_1.0.13             xtable_1.8-4           </span></span>
+<span><span class="co">#&gt; [76] glue_1.7.0              DBI_1.2.3               BiocGenerics_0.51.0    </span></span>
+<span><span class="co">#&gt; [79] jsonlite_1.8.9          R6_2.5.1                zlibbioc_1.51.1        </span></span>
+<span><span class="co">#&gt; [82] systemfonts_1.1.0       fs_1.6.4</span></span></code></pre></div>
 </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside>
 </div>
 
@@ -460,15 +495,15 @@ <h2 class="unnumbered" id="session-information">Session information<a class="anc
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
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diff --git a/articles/clinvar.html b/articles/clinvar.html
index b7fcc52..d1b0166 100644
--- a/articles/clinvar.html
+++ b/articles/clinvar.html
@@ -5,67 +5,51 @@
 <meta charset="utf-8">
 <meta http-equiv="X-UA-Compatible" content="IE=edge">
 <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
-<meta name="description" content="AlphaMissenseR">
 <title>C. ClinVar Integration • AlphaMissenseR</title>
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-<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
-<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous">
-<!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="C. ClinVar Integration">
-<meta property="og:description" content="AlphaMissenseR">
-<!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
-<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
-<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]-->
+<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet">
+<link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet">
+<script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="C. ClinVar Integration">
 </head>
 <body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
-    
 
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+    <nav class="navbar navbar-expand-lg fixed-top bg-light" data-bs-theme="light" aria-label="Site navigation"><div class="container">
+
     <a class="navbar-brand me-2" href="../index.html">AlphaMissenseR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.5</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
 
-    
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
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-  <a class="nav-link" href="../reference/index.html">Reference</a>
-</li>
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-  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
-  <div class="dropdown-menu" aria-labelledby="dropdown-articles">
-    <a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a>
-    <a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a>
-    <a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a>
-    <a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a>
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+<li class="nav-item"><a class="nav-link" href="../reference/index.html">Reference</a></li>
+<li class="nav-item dropdown">
+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles">
+<li><a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a></li>
+  </ul>
 </li>
+<li class="nav-item"><a class="nav-link" href="../news/index.html">Changelog</a></li>
       </ul>
-<form class="form-inline my-2 my-lg-0" role="search">
-        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off">
-</form>
-
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-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="github">
-    <span class="fab fa fab fa-github fa-lg"></span>
-     
-  </a>
-</li>
+<ul class="navbar-nav">
+<li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json">
+</form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
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   </div>
 </nav><div class="container template-article">
 
@@ -74,7 +58,8 @@
 
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>C. ClinVar Integration</h1>
+
+      <h1>C. ClinVar Integration</h1>
             
       
       <small class="dont-index">Source: <a href="https://github.com/mtmorgan/AlphaMissenseR/blob/HEAD/vignettes/clinvar.Rmd" class="external-link"><code>vignettes/clinvar.Rmd</code></a></small>
@@ -107,7 +92,7 @@ <h2 id="access-clinvar-classifications-with-alphamissense-predictions">Access Cl
 <div class="sourceCode" id="cb2"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="../reference/ClinVar.html">clinvar_data</a></span><span class="op">(</span><span class="op">)</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Source:   table&lt;clinvar&gt; [?? x 5]</span></span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span></span>
 <span><span class="co">#&gt;    variant_id           transcript_id     protein_variant AlphaMissense label </span></span>
 <span><span class="co">#&gt;    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>                <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>             <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>                   <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span> <span style="color: #949494; font-style: italic;">&lt;fct&gt;</span> </span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;"> 1</span> chr1_925969_C_T_hg38 ENST00000342066.8 Q96NU1:P10S            0.967  benign</span></span>
@@ -136,8 +121,8 @@ <h2 id="compare-clinvar-and-alphamissense">Compare ClinVar and AlphaMissense<a c
 function. See function details for more information.</p>
 <div class="sourceCode" id="cb3"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="../reference/ClinVar.html">clinvar_plot</a></span><span class="op">(</span>uniprotId <span class="op">=</span> <span class="st">"P37023"</span><span class="op">)</span></span>
-<span><span class="co">#&gt; * [14:05:22][info] 'alphamissense_table' not provided, using default 'am_data("aa_substitution")' table accessed through the AlphaMissenseR package</span></span>
-<span><span class="co">#&gt; * [14:05:24][info] 'clinvar_table' not provided, using default ClinVar dataset in AlphaMissenseR package</span></span></code></pre></div>
+<span><span class="co">#&gt; * [11:38:51][info] 'alphamissense_table' not provided, using default 'am_data("aa_substitution")' table accessed through the AlphaMissenseR package</span></span>
+<span><span class="co">#&gt; * [11:38:54][info] 'clinvar_table' not provided, using default ClinVar dataset in AlphaMissenseR package</span></span></code></pre></div>
 <p><img src="clinvar_files/figure-html/plot_P37023-1.png" width="672"></p>
 <p>We returned a <code>ggplot</code> object which overlays ClinVar
 classifications onto AlphaMissense predicted scores. Blue, gray, and red
@@ -162,13 +147,13 @@ <h2 class="unnumbered" id="session-information">Session information<a class="anc
 </h2>
 <div class="sourceCode" id="cb5"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/utils/sessionInfo.html" class="external-link">sessionInfo</a></span><span class="op">(</span><span class="op">)</span></span>
-<span><span class="co">#&gt; R version 4.4.1 Patched (2024-06-20 r86819)</span></span>
-<span><span class="co">#&gt; Platform: aarch64-apple-darwin23.5.0</span></span>
-<span><span class="co">#&gt; Running under: macOS Sonoma 14.5</span></span>
+<span><span class="co">#&gt; R Under development (unstable) (2024-07-31 r86945)</span></span>
+<span><span class="co">#&gt; Platform: aarch64-apple-darwin23.4.0</span></span>
+<span><span class="co">#&gt; Running under: macOS Sonoma 14.6.1</span></span>
 <span><span class="co">#&gt; </span></span>
 <span><span class="co">#&gt; Matrix products: default</span></span>
-<span><span class="co">#&gt; BLAS:   /Users/ma38727/bin/R-4-4-branch/lib/libRblas.dylib </span></span>
-<span><span class="co">#&gt; LAPACK: /Users/ma38727/bin/R-4-4-branch/lib/libRlapack.dylib;  LAPACK version 3.12.0</span></span>
+<span><span class="co">#&gt; BLAS:   /Users/mtmorgan/bin/R-devel/lib/libRblas.dylib </span></span>
+<span><span class="co">#&gt; LAPACK: /Users/mtmorgan/bin/R-devel/lib/libRlapack.dylib;  LAPACK version 3.12.0</span></span>
 <span><span class="co">#&gt; </span></span>
 <span><span class="co">#&gt; locale:</span></span>
 <span><span class="co">#&gt; [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8</span></span>
@@ -185,28 +170,28 @@ <h2 class="unnumbered" id="session-information">Session information<a class="anc
 <span><span class="co">#&gt; loaded via a namespace (and not attached):</span></span>
 <span><span class="co">#&gt;  [1] tidyr_1.3.1          sass_0.4.9           utf8_1.2.4          </span></span>
 <span><span class="co">#&gt;  [4] generics_0.1.3       spdl_0.0.5           RSQLite_2.3.7       </span></span>
-<span><span class="co">#&gt;  [7] digest_0.6.36        magrittr_2.0.3       evaluate_0.24.0     </span></span>
-<span><span class="co">#&gt; [10] grid_4.4.1           fastmap_1.2.0        blob_1.2.4          </span></span>
-<span><span class="co">#&gt; [13] jsonlite_1.8.8       whisker_0.4.1        DBI_1.2.3           </span></span>
+<span><span class="co">#&gt;  [7] digest_0.6.37        magrittr_2.0.3       evaluate_0.24.0     </span></span>
+<span><span class="co">#&gt; [10] grid_4.5.0           fastmap_1.2.0        blob_1.2.4          </span></span>
+<span><span class="co">#&gt; [13] jsonlite_1.8.9       whisker_0.4.1        DBI_1.2.3           </span></span>
 <span><span class="co">#&gt; [16] httr_1.4.7           purrr_1.0.2          fansi_1.0.6         </span></span>
 <span><span class="co">#&gt; [19] scales_1.3.0         textshaping_0.4.0    jquerylib_0.1.4     </span></span>
-<span><span class="co">#&gt; [22] duckdb_1.0.0         cli_3.6.3            rlang_1.1.4         </span></span>
-<span><span class="co">#&gt; [25] dbplyr_2.5.0         bit64_4.0.5          munsell_0.5.1       </span></span>
-<span><span class="co">#&gt; [28] withr_3.0.0          cachem_1.1.0         yaml_2.3.8          </span></span>
-<span><span class="co">#&gt; [31] BiocBaseUtils_1.7.0  tools_4.4.1          memoise_2.0.1       </span></span>
-<span><span class="co">#&gt; [34] colorspace_2.1-0     ggplot2_3.5.1        filelock_1.0.3      </span></span>
-<span><span class="co">#&gt; [37] curl_5.2.1           rjsoncons_1.3.0      vctrs_0.6.5         </span></span>
+<span><span class="co">#&gt; [22] duckdb_1.0.0-2       cli_3.6.3            rlang_1.1.4         </span></span>
+<span><span class="co">#&gt; [25] dbplyr_2.5.0         munsell_0.5.1        bit64_4.0.5         </span></span>
+<span><span class="co">#&gt; [28] withr_3.0.1          cachem_1.1.0         yaml_2.3.10         </span></span>
+<span><span class="co">#&gt; [31] BiocBaseUtils_1.7.3  tools_4.5.0          memoise_2.0.1       </span></span>
+<span><span class="co">#&gt; [34] colorspace_2.1-1     ggplot2_3.5.1        filelock_1.0.3      </span></span>
+<span><span class="co">#&gt; [37] curl_5.2.3           rjsoncons_1.3.1      vctrs_0.6.5         </span></span>
 <span><span class="co">#&gt; [40] R6_2.5.1             BiocFileCache_2.13.0 lifecycle_1.0.4     </span></span>
-<span><span class="co">#&gt; [43] RcppSpdlog_0.0.17    fs_1.6.4             htmlwidgets_1.6.4   </span></span>
+<span><span class="co">#&gt; [43] RcppSpdlog_0.0.18    fs_1.6.4             htmlwidgets_1.6.4   </span></span>
 <span><span class="co">#&gt; [46] bit_4.0.5            ragg_1.3.2           pkgconfig_2.0.3     </span></span>
-<span><span class="co">#&gt; [49] desc_1.4.3           pkgdown_2.0.9        pillar_1.9.0        </span></span>
-<span><span class="co">#&gt; [52] bslib_0.7.0          gtable_0.3.5         Rcpp_1.0.12         </span></span>
+<span><span class="co">#&gt; [49] desc_1.4.3           pkgdown_2.1.0        pillar_1.9.0        </span></span>
+<span><span class="co">#&gt; [52] bslib_0.8.0          gtable_0.3.5         Rcpp_1.0.13         </span></span>
 <span><span class="co">#&gt; [55] glue_1.7.0           systemfonts_1.1.0    highr_0.11          </span></span>
-<span><span class="co">#&gt; [58] xfun_0.45            tibble_3.2.1         tidyselect_1.2.1    </span></span>
-<span><span class="co">#&gt; [61] knitr_1.47           farver_2.1.2         htmltools_0.5.8.1   </span></span>
-<span><span class="co">#&gt; [64] labeling_0.4.3       rmarkdown_2.27       compiler_4.4.1</span></span></code></pre></div>
+<span><span class="co">#&gt; [58] xfun_0.47            tibble_3.2.1         tidyselect_1.2.1    </span></span>
+<span><span class="co">#&gt; [61] knitr_1.48           farver_2.1.2         htmltools_0.5.8.1   </span></span>
+<span><span class="co">#&gt; [64] labeling_0.4.3       rmarkdown_2.28       compiler_4.5.0</span></span></code></pre></div>
 </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside>
 </div>
 
@@ -217,15 +202,15 @@ <h2 class="unnumbered" id="session-information">Session information<a class="anc
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
 </div>
 
     </footer>
 </div>
 
-  
 
-  
+
+
 
   </body>
 </html>
diff --git a/articles/images/gosling_bar.png b/articles/images/gosling_bar.png
new file mode 100644
index 0000000..8e3f7ae
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diff --git a/articles/images/gosling_lollipop.png b/articles/images/gosling_lollipop.png
new file mode 100644
index 0000000..14b111b
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diff --git a/articles/index.html b/articles/index.html
index 5d80f9b..2378729 100644
--- a/articles/index.html
+++ b/articles/index.html
@@ -1,55 +1,41 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Articles • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Articles"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
-<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
-<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]--></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Articles • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Articles"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
-    
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light" data-bs-theme="light"><div class="container">
-    
+
+    <nav class="navbar navbar-expand-lg fixed-top bg-light" data-bs-theme="light" aria-label="Site navigation"><div class="container">
+
     <a class="navbar-brand me-2" href="../index.html">AlphaMissenseR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.5</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
 
-    
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
       <span class="navbar-toggler-icon"></span>
     </button>
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
-      <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
-</li>
+      <ul class="navbar-nav me-auto"><li class="nav-item"><a class="nav-link" href="../reference/index.html">Reference</a></li>
 <li class="nav-item dropdown">
-  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
-  <div class="dropdown-menu" aria-labelledby="dropdown-articles">
-    <a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a>
-    <a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a>
-    <a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a>
-    <a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a>
-  </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../news/index.html">Changelog</a>
-</li>
-      </ul><form class="form-inline my-2 my-lg-0" role="search">
-        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
-
-      <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="github">
-    <span class="fab fa fab fa-github fa-lg"></span>
-     
-  </a>
-</li>
+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles"><li><a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a></li>
+  </ul></li>
+<li class="nav-item"><a class="nav-link" href="../news/index.html">Changelog</a></li>
+      </ul><ul class="navbar-nav"><li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json"></form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
       </ul></div>
 
-    
+
   </div>
 </nav><div class="container template-article-index">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>Articles</h1>
+
+      <h1>Articles</h1>
     </div>
 
     <div class="section ">
@@ -73,14 +59,14 @@ <h3>Using AlphaMissenseR</h3>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
 </div>
 
     </footer></div>
 
-  
 
-  
+
+
 
   </body></html>
 
diff --git a/articles/introduction.html b/articles/introduction.html
index fd11252..d6544a4 100644
--- a/articles/introduction.html
+++ b/articles/introduction.html
@@ -5,67 +5,51 @@
 <meta charset="utf-8">
 <meta http-equiv="X-UA-Compatible" content="IE=edge">
 <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
-<meta name="description" content="AlphaMissenseR">
 <title>A. Introduction • AlphaMissenseR</title>
 <script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
 <link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet">
-<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
-<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous">
-<!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="A. Introduction">
-<meta property="og:description" content="AlphaMissenseR">
-<!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
-<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
-<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]-->
+<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet">
+<link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet">
+<script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="A. Introduction">
 </head>
 <body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
-    
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light" data-bs-theme="light"><div class="container">
-    
+
+    <nav class="navbar navbar-expand-lg fixed-top bg-light" data-bs-theme="light" aria-label="Site navigation"><div class="container">
+
     <a class="navbar-brand me-2" href="../index.html">AlphaMissenseR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.5</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
 
-    
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
       <span class="navbar-toggler-icon"></span>
     </button>
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
       <ul class="navbar-nav me-auto">
-<li class="nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
-</li>
-<li class="active nav-item dropdown">
-  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
-  <div class="dropdown-menu" aria-labelledby="dropdown-articles">
-    <a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a>
-    <a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a>
-    <a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a>
-    <a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a>
-  </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../news/index.html">Changelog</a>
+<li class="nav-item"><a class="nav-link" href="../reference/index.html">Reference</a></li>
+<li class="nav-item dropdown">
+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles">
+<li><a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a></li>
+  </ul>
 </li>
+<li class="nav-item"><a class="nav-link" href="../news/index.html">Changelog</a></li>
       </ul>
-<form class="form-inline my-2 my-lg-0" role="search">
-        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off">
-</form>
-
-      <ul class="navbar-nav">
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="github">
-    <span class="fab fa fab fa-github fa-lg"></span>
-     
-  </a>
-</li>
+<ul class="navbar-nav">
+<li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json">
+</form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
       </ul>
 </div>
 
-    
+
   </div>
 </nav><div class="container template-article">
 
@@ -74,7 +58,8 @@
 
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>A. Introduction</h1>
+
+      <h1>A. Introduction</h1>
             
       
       <small class="dont-index">Source: <a href="https://github.com/mtmorgan/AlphaMissenseR/blob/HEAD/vignettes/introduction.Rmd" class="external-link"><code>vignettes/introduction.Rmd</code></a></small>
@@ -158,7 +143,7 @@ <h2 id="discovery-retrieval-and-use">Discovery, retrieval and use<a class="ancho
 <code class="sourceCode R"><span><span class="va">tbl</span> <span class="op">&lt;-</span> <span class="fu"><a href="../reference/AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"hg38"</span><span class="op">)</span></span>
 <span><span class="va">tbl</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Source:   table&lt;hg38&gt; [?? x 10]</span></span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span></span>
 <span><span class="co">#&gt;    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant</span></span>
 <span><span class="co">#&gt;    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>  <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>      <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>             <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>          </span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;"> 1</span> chr1  <span style="text-decoration: underline;">69</span>094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L            </span></span>
@@ -186,13 +171,12 @@ <h2 id="discovery-retrieval-and-use">Discovery, retrieval and use<a class="ancho
 the table of interest.</p>
 <div class="sourceCode" id="cb9"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="../reference/db.html">db_tables</a></span><span class="op">(</span><span class="va">db</span><span class="op">)</span></span>
-<span><span class="co">#&gt; [1] "aa_substitutions" "clinvar"          "gene_hg38"        "hg38"</span></span></code></pre></div>
-<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r">
-<code class="sourceCode R"><span></span>
-<span><span class="va">tbl</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://dplyr.tidyverse.org/reference/tbl.html" class="external-link">tbl</a></span><span class="op">(</span><span class="va">db</span>, <span class="st">"hg38"</span><span class="op">)</span></span>
+<span><span class="co">#&gt; [1] "aa_substitutions" "clinvar"          "gene_hg38"        "hg38"</span></span>
+<span></span>
+<span><span class="va">tbl</span> <span class="op">&lt;-</span> <span class="fu">tbl</span><span class="op">(</span><span class="va">db</span>, <span class="st">"hg38"</span><span class="op">)</span></span>
 <span><span class="va">tbl</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Source:   table&lt;hg38&gt; [?? x 10]</span></span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span></span>
 <span><span class="co">#&gt;    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant</span></span>
 <span><span class="co">#&gt;    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>  <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>      <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>             <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>          </span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;"> 1</span> chr1  <span style="text-decoration: underline;">69</span>094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L            </span></span>
@@ -209,23 +193,23 @@ <h2 id="discovery-retrieval-and-use">Discovery, retrieval and use<a class="ancho
 <span><span class="co">#&gt; <span style="color: #949494;"># ℹ 2 more variables: am_pathogenicity &lt;dbl&gt;, am_class &lt;chr&gt;</span></span></span></code></pre></div>
 <p>It is fast and straight-forward to summarize the data, e.g., the
 number of variants assigned to each pathogenicity class.</p>
-<div class="sourceCode" id="cb11"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb10"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">tbl</span> <span class="op">|&gt;</span></span>
-<span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/count.html" class="external-link">count</a></span><span class="op">(</span><span class="va">am_class</span><span class="op">)</span></span>
+<span>    <span class="fu">count</span><span class="op">(</span><span class="va">am_class</span><span class="op">)</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Source:   SQL [3 x 2]</span></span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span></span>
 <span><span class="co">#&gt;   am_class                 n</span></span>
 <span><span class="co">#&gt;   <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>                <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span></span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;">1</span> likely_pathogenic 22<span style="text-decoration: underline;">770</span>557</span></span>
-<span><span class="co">#&gt; <span style="color: #BCBCBC;">2</span> ambiguous          8<span style="text-decoration: underline;">009</span>648</span></span>
-<span><span class="co">#&gt; <span style="color: #BCBCBC;">3</span> likely_benign     40<span style="text-decoration: underline;">917</span>351</span></span></code></pre></div>
+<span><span class="co">#&gt; <span style="color: #BCBCBC;">2</span> likely_benign     40<span style="text-decoration: underline;">917</span>351</span></span>
+<span><span class="co">#&gt; <span style="color: #BCBCBC;">3</span> ambiguous          8<span style="text-decoration: underline;">009</span>648</span></span></code></pre></div>
 <p>Or the average pathogenicity score in each class…</p>
-<div class="sourceCode" id="cb12"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb11"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">tbl</span> <span class="op">|&gt;</span></span>
-<span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/group_by.html" class="external-link">group_by</a></span><span class="op">(</span><span class="va">am_class</span><span class="op">)</span> <span class="op">|&gt;</span></span>
-<span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/summarise.html" class="external-link">summarize</a></span><span class="op">(</span>n <span class="op">=</span> <span class="fu"><a href="https://dplyr.tidyverse.org/reference/context.html" class="external-link">n</a></span><span class="op">(</span><span class="op">)</span>, pathogenecity <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/mean.html" class="external-link">mean</a></span><span class="op">(</span><span class="va">am_pathogenicity</span>, na.rm <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span>
+<span>    <span class="fu">group_by</span><span class="op">(</span><span class="va">am_class</span><span class="op">)</span> <span class="op">|&gt;</span></span>
+<span>    <span class="fu">summarize</span><span class="op">(</span>n <span class="op">=</span> <span class="fu">n</span><span class="op">(</span><span class="op">)</span>, pathogenecity <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/mean.html" class="external-link">mean</a></span><span class="op">(</span><span class="va">am_pathogenicity</span>, na.rm <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Source:   SQL [3 x 3]</span></span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span></span>
 <span><span class="co">#&gt;   am_class                 n pathogenecity</span></span>
 <span><span class="co">#&gt;   <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>                <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span>         <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span></span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;">1</span> likely_benign     40<span style="text-decoration: underline;">917</span>351         0.147</span></span>
@@ -233,14 +217,14 @@ <h2 id="discovery-retrieval-and-use">Discovery, retrieval and use<a class="ancho
 <span><span class="co">#&gt; <span style="color: #BCBCBC;">3</span> ambiguous          8<span style="text-decoration: underline;">009</span>648         0.444</span></span></code></pre></div>
 <p>Or the number of transitions between <code>REF</code> and
 <code>ALT</code> nucleotides across all variants.</p>
-<div class="sourceCode" id="cb13"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb12"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">tbl</span> <span class="op">|&gt;</span></span>
-<span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/count.html" class="external-link">count</a></span><span class="op">(</span><span class="va">REF</span>, <span class="va">ALT</span><span class="op">)</span> <span class="op">|&gt;</span></span>
+<span>    <span class="fu">count</span><span class="op">(</span><span class="va">REF</span>, <span class="va">ALT</span><span class="op">)</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu">tidyr</span><span class="fu">::</span><span class="fu"><a href="https://tidyr.tidyverse.org/reference/pivot_wider.html" class="external-link">pivot_wider</a></span><span class="op">(</span>names_from <span class="op">=</span> <span class="st">"ALT"</span>, values_from <span class="op">=</span> <span class="st">"n"</span><span class="op">)</span> <span class="op">|&gt;</span></span>
-<span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/select.html" class="external-link">select</a></span><span class="op">(</span><span class="st">"REF"</span>, <span class="st">"A"</span>, <span class="st">"C"</span>, <span class="st">"G"</span>, <span class="st">"T"</span><span class="op">)</span> <span class="op">|&gt;</span></span>
-<span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/arrange.html" class="external-link">arrange</a></span><span class="op">(</span><span class="va">REF</span><span class="op">)</span></span>
+<span>    <span class="fu">select</span><span class="op">(</span><span class="st">"REF"</span>, <span class="st">"A"</span>, <span class="st">"C"</span>, <span class="st">"G"</span>, <span class="st">"T"</span><span class="op">)</span> <span class="op">|&gt;</span></span>
+<span>    <span class="fu">arrange</span><span class="op">(</span><span class="va">REF</span><span class="op">)</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Source:     SQL [4 x 5]</span></span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># Database:   DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># Database:   DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Ordered by: REF</span></span></span>
 <span><span class="co">#&gt;   REF         A       C       G       T</span></span>
 <span><span class="co">#&gt;   <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>   <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span>   <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span>   <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span>   <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span></span></span>
@@ -250,11 +234,11 @@ <h2 id="discovery-retrieval-and-use">Discovery, retrieval and use<a class="ancho
 <span><span class="co">#&gt; <span style="color: #BCBCBC;">4</span> T     5<span style="text-decoration: underline;">955</span>039 5<span style="text-decoration: underline;">445</span>540 6<span style="text-decoration: underline;">423</span>927      <span style="color: #BB0000;">NA</span></span></span></code></pre></div>
 <p>It is straight-forward to select variants in individual regions of
 interest, e.g., the first 200000 nucleoties of chromosome 4.</p>
-<div class="sourceCode" id="cb14"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb13"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">tbl</span> <span class="op">|&gt;</span></span>
-<span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">CHROM</span> <span class="op">==</span> <span class="st">"chr4"</span>, <span class="va">POS</span> <span class="op">&gt;</span> <span class="fl">0</span>, <span class="va">POS</span> <span class="op">&lt;=</span> <span class="fl">200000</span><span class="op">)</span></span>
+<span>    <span class="fu"><a href="https://rdrr.io/r/stats/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">CHROM</span> <span class="op">==</span> <span class="st">"chr4"</span>, <span class="va">POS</span> <span class="op">&gt;</span> <span class="fl">0</span>, <span class="va">POS</span> <span class="op">&lt;=</span> <span class="fl">200000</span><span class="op">)</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Source:   SQL [?? x 10]</span></span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span></span>
 <span><span class="co">#&gt;    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant</span></span>
 <span><span class="co">#&gt;    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>  <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>      <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>             <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>          </span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;"> 1</span> chr4  <span style="text-decoration: underline;">59</span>430 G     C     hg38   Q8IYB9     ENST00000610261.6 E2Q            </span></span>
@@ -289,19 +273,19 @@ <h3 id="genomic-ranges">Genomic ranges<a class="anchor" aria-label="anchor" href
 <code>hg38</code> AlphaMissense resources. Start by installing (if
 necessary) the <a href="https://bioconductor.org/packages/GenomicRanges" class="external-link">GenomicRanges</a>
 package.</p>
-<div class="sourceCode" id="cb15"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb14"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="kw">if</span> <span class="op">(</span><span class="op">!</span><span class="fu"><a href="https://rdrr.io/r/base/ns-load.html" class="external-link">requireNamespace</a></span><span class="op">(</span><span class="st">"GenomicRanges"</span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span></span>
 <span>    <span class="fu">BiocManager</span><span class="fu">::</span><span class="fu"><a href="https://bioconductor.github.io/BiocManager/reference/install.html" class="external-link">install</a></span><span class="op">(</span><span class="st">"GenomicRanges"</span><span class="op">)</span></span></code></pre></div>
 <p>Select the <code>hg38</code> data resource, and filter to a subset of
 variants; <code>GPos</code> is an in-memory data structure and can
 easily manage 10’s of millions of variants.</p>
-<div class="sourceCode" id="cb16"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb15"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">tbl</span> <span class="op">&lt;-</span></span>
 <span>    <span class="fu"><a href="../reference/AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"hg38"</span><span class="op">)</span> <span class="op">|&gt;</span></span>
-<span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">CHROM</span> <span class="op">==</span> <span class="st">"chr2"</span>, <span class="va">POS</span> <span class="op">&lt;</span> <span class="fl">10000000</span>, <span class="va">REF</span> <span class="op">==</span> <span class="st">"G"</span><span class="op">)</span></span></code></pre></div>
+<span>    <span class="fu"><a href="https://rdrr.io/r/stats/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">CHROM</span> <span class="op">==</span> <span class="st">"chr2"</span>, <span class="va">POS</span> <span class="op">&lt;</span> <span class="fl">10000000</span>, <span class="va">REF</span> <span class="op">==</span> <span class="st">"G"</span><span class="op">)</span></span></code></pre></div>
 <p>Use <code><a href="../reference/GenomicRanges.html">to_GPos()</a></code> to coerce to a <code>GPos</code>
 object.</p>
-<div class="sourceCode" id="cb17"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb16"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">gpos</span> <span class="op">&lt;-</span></span>
 <span>    <span class="va">tbl</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu"><a href="../reference/GenomicRanges.html">to_GPos</a></span><span class="op">(</span><span class="op">)</span></span>
@@ -337,7 +321,7 @@ <h3 id="genomic-ranges">Genomic ranges<a class="anchor" aria-label="anchor" href
 <span><span class="co">#&gt;   seqinfo: 25 sequences (1 circular) from hg38 genome</span></span></code></pre></div>
 <p>Vignettes in the <a href="https://bioconductor.org/packages/GenomicRanges" class="external-link">GenomicRanges</a>
 package illustrate use of these objects.</p>
-<div class="sourceCode" id="cb18"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb17"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu">utils</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/r/utils/browseVignettes.html" class="external-link">browseVignettes</a></span><span class="op">(</span><span class="st">"GenomicRanges"</span><span class="op">)</span></span></code></pre></div>
 </div>
 <div class="section level3">
@@ -345,11 +329,11 @@ <h3 id="grch38-annotation-resources">GRCh38 annotation resources<a class="anchor
 </h3>
 <p>Start by identifying the most recent EnsDb resource for <em>Homo
 Sapiens</em>.</p>
-<div class="sourceCode" id="cb19"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb18"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">hub</span> <span class="op">&lt;-</span> <span class="fu">AnnotationHub</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/AnnotationHub/man/AnnotationHub-class.html" class="external-link">AnnotationHub</a></span><span class="op">(</span><span class="op">)</span></span>
 <span><span class="fu">AnnotationHub</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/AnnotationHub/man/AnnotationHub-class.html" class="external-link">query</a></span><span class="op">(</span><span class="va">hub</span>, <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"EnsDb"</span>, <span class="st">"Homo sapiens"</span><span class="op">)</span><span class="op">)</span></span>
 <span><span class="co">#&gt; AnnotationHub with 27 records</span></span>
-<span><span class="co">#&gt; # snapshotDate(): 2024-06-21</span></span>
+<span><span class="co">#&gt; # snapshotDate(): 2024-08-01</span></span>
 <span><span class="co">#&gt; # $dataprovider: Ensembl</span></span>
 <span><span class="co">#&gt; # $species: Homo sapiens</span></span>
 <span><span class="co">#&gt; # $rdataclass: EnsDb</span></span>
@@ -369,12 +353,11 @@ <h3 id="grch38-annotation-resources">GRCh38 annotation resources<a class="anchor
 <span><span class="co">#&gt;   AH109606 | Ensembl 109 EnsDb for Homo sapiens</span></span>
 <span><span class="co">#&gt;   AH113665 | Ensembl 110 EnsDb for Homo sapiens</span></span>
 <span><span class="co">#&gt;   AH116291 | Ensembl 111 EnsDb for Homo sapiens</span></span>
-<span><span class="co">#&gt;   AH116860 | Ensembl 112 EnsDb for Homo sapiens</span></span></code></pre></div>
-<div class="sourceCode" id="cb20"><pre class="downlit sourceCode r">
-<code class="sourceCode R"><span></span>
+<span><span class="co">#&gt;   AH116860 | Ensembl 112 EnsDb for Homo sapiens</span></span>
+<span></span>
 <span><span class="fu">AnnotationHub</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/AnnotationHub/man/AnnotationHub-class.html" class="external-link">AnnotationHub</a></span><span class="op">(</span><span class="op">)</span><span class="op">[</span><span class="st">"AH113665"</span><span class="op">]</span></span>
 <span><span class="co">#&gt; AnnotationHub with 1 record</span></span>
-<span><span class="co">#&gt; # snapshotDate(): 2024-06-21</span></span>
+<span><span class="co">#&gt; # snapshotDate(): 2024-08-01</span></span>
 <span><span class="co">#&gt; # names(): AH113665</span></span>
 <span><span class="co">#&gt; # $dataprovider: Ensembl</span></span>
 <span><span class="co">#&gt; # $species: Homo sapiens</span></span>
@@ -395,7 +378,7 @@ <h3 id="grch38-annotation-resources">GRCh38 annotation resources<a class="anchor
 and retrieve the record. Unfortunately, there are many conflicts between
 function names in different packages, so it becomes necessary to fully
 resolve functions to the package where they are defined.</p>
-<div class="sourceCode" id="cb21"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb19"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="kw"><a href="https://rdrr.io/r/base/library.html" class="external-link">library</a></span><span class="op">(</span><span class="va"><a href="https://github.com/jorainer/ensembldb" class="external-link">ensembldb</a></span><span class="op">)</span></span>
 <span><span class="va">edb</span> <span class="op">&lt;-</span> <span class="fu">AnnotationHub</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/AnnotationHub/man/AnnotationHub-class.html" class="external-link">AnnotationHub</a></span><span class="op">(</span><span class="op">)</span><span class="op">[[</span><span class="st">"AH113665"</span><span class="op">]</span><span class="op">]</span></span>
 <span><span class="va">edb</span></span>
@@ -426,11 +409,11 @@ <h3 id="from-bioconductor-to-duckdb">From <em>Bioconductor</em> to <em>DuckDB</e
 including writing temporary tables. For illustration purposes, we use a
 connection that can read and write; in practice, read-only permissions
 are sufficient for creating temporary tables.</p>
-<div class="sourceCode" id="cb22"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb20"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">db_rw</span> <span class="op">&lt;-</span> <span class="fu"><a href="../reference/db.html">db_connect</a></span><span class="op">(</span>read_only <span class="op">=</span> <span class="cn">FALSE</span><span class="op">)</span></span></code></pre></div>
 <p>As an illustration, use <a href="https://bioconductor.org/packages/ensembldb" class="external-link">ensembldb</a> to
 identify the exons of the canonical transcript of a particular gene.</p>
-<div class="sourceCode" id="cb23"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb21"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">bcl2l11</span> <span class="op">&lt;-</span></span>
 <span>    <span class="va">edb</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu">ensembldb</span><span class="fu">::</span><span class="fu"><a href="https://rdrr.io/pkg/ensembldb/man/global-filters.html" class="external-link">filter</a></span><span class="op">(</span></span>
@@ -457,16 +440,16 @@ <h3 id="from-bioconductor-to-duckdb">From <em>Bioconductor</em> to <em>DuckDB</e
 (it will be deleted when <code>db</code> is disconnected from the
 database) so that it can be used in ‘lazy’ SQL queries with the
 AlphaMissense data.</p>
-<div class="sourceCode" id="cb24"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb22"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">bcl2l11_tbl</span> <span class="op">&lt;-</span></span>
 <span>    <span class="va">bcl2l11</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://tibble.tidyverse.org/reference/as_tibble.html" class="external-link">as_tibble</a></span><span class="op">(</span><span class="op">)</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/mutate.html" class="external-link">mutate</a></span><span class="op">(</span>CHROM <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="st">"chr"</span>, <span class="va">seqnames</span><span class="op">)</span><span class="op">)</span> <span class="op">|&gt;</span></span>
-<span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/select.html" class="external-link">select</a></span><span class="op">(</span><span class="va">CHROM</span>, <span class="fu"><a href="https://tidyselect.r-lib.org/reference/everything.html" class="external-link">everything</a></span><span class="op">(</span><span class="op">)</span>, <span class="op">-</span><span class="va">seqnames</span><span class="op">)</span></span>
+<span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/select.html" class="external-link">select</a></span><span class="op">(</span><span class="va">CHROM</span>, <span class="fu">everything</span><span class="op">(</span><span class="op">)</span>, <span class="op">-</span><span class="va">seqnames</span><span class="op">)</span></span>
 <span></span>
 <span><span class="fu"><a href="../reference/db.html">db_temporary_table</a></span><span class="op">(</span><span class="va">db_rw</span>, <span class="va">bcl2l11_tbl</span>, <span class="st">"bcl2l11"</span><span class="op">)</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Source:   table&lt;bcl2l11&gt; [4 x 9]</span></span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span></span>
 <span><span class="co">#&gt;   CHROM group group_name          start       end width strand exon_id exon_rank</span></span>
 <span><span class="co">#&gt;   <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;int&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>               <span style="color: #949494; font-style: italic;">&lt;int&gt;</span>     <span style="color: #949494; font-style: italic;">&lt;int&gt;</span> <span style="color: #949494; font-style: italic;">&lt;int&gt;</span> <span style="color: #949494; font-style: italic;">&lt;fct&gt;</span>  <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>       <span style="color: #949494; font-style: italic;">&lt;int&gt;</span></span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;">1</span> chr2      1 ENST00000393256 111<span style="text-decoration: underline;">120</span>914 111<span style="text-decoration: underline;">121</span>188   275 +      ENSE00…         1</span></span>
@@ -476,7 +459,7 @@ <h3 id="from-bioconductor-to-duckdb">From <em>Bioconductor</em> to <em>DuckDB</e
 <p>The temporary table is now available on the <code>db_rw</code>
 connection; the tables will be removed on disconnect,
 <code>db_disconnect(db_rw)</code>.</p>
-<div class="sourceCode" id="cb25"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb23"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="st">"bcl2l11"</span> <span class="op"><a href="https://rdrr.io/pkg/BiocGenerics/man/match.html" class="external-link">%in%</a></span> <span class="fu"><a href="../reference/db.html">db_tables</a></span><span class="op">(</span><span class="va">db_rw</span><span class="op">)</span></span>
 <span><span class="co">#&gt; [1] TRUE</span></span></code></pre></div>
 <p>Use <code><a href="../reference/db.html">db_range_join()</a></code> to join the AlphaMissense data with
@@ -494,11 +477,11 @@ <h3 id="from-bioconductor-to-duckdb">From <em>Bioconductor</em> to <em>DuckDB</e
 Writing to a temporary table avoids bringing potentially large datasets
 into R memory, and makes the table available for subsequent manipulation
 in the current session.</p>
-<div class="sourceCode" id="cb26"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb24"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">rng</span> <span class="op">&lt;-</span> <span class="fu"><a href="../reference/db.html">db_range_join</a></span><span class="op">(</span><span class="va">db_rw</span>, <span class="st">"hg38"</span>, <span class="st">"bcl2l11"</span>, <span class="st">"bcl2l11_overlaps"</span><span class="op">)</span></span>
 <span><span class="va">rng</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Source:   table&lt;bcl2l11_overlaps&gt; [?? x 18]</span></span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span></span>
 <span><span class="co">#&gt;    CHROM       POS REF   ALT   genome uniprot_id transcript_id   protein_variant</span></span>
 <span><span class="co">#&gt;    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>     <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>  <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>      <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>           <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>          </span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;"> 1</span> chr2  111<span style="text-decoration: underline;">164</span>133 G     A     hg38   O43521     ENST0000039325… V167I          </span></span>
@@ -520,34 +503,34 @@ <h3 id="from-bioconductor-to-duckdb">From <em>Bioconductor</em> to <em>DuckDB</e
 <p>The usual database and <a href="https://cran.r-project.org/package=dplyr" class="external-link">dplyr</a> verbs can be
 used to summarize the results, e.g., the number of variants in each
 pathogenecity class in each exon.</p>
-<div class="sourceCode" id="cb27"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb25"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">rng</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/count.html" class="external-link">count</a></span><span class="op">(</span><span class="va">exon_id</span>, <span class="va">am_class</span><span class="op">)</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu">tidyr</span><span class="fu">::</span><span class="fu"><a href="https://tidyr.tidyverse.org/reference/pivot_wider.html" class="external-link">pivot_wider</a></span><span class="op">(</span>names_from <span class="op">=</span> <span class="st">"am_class"</span>, values_from <span class="op">=</span> <span class="st">"n"</span><span class="op">)</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Source:   SQL [3 x 4]</span></span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span></span>
 <span><span class="co">#&gt;   exon_id         likely_benign likely_pathogenic ambiguous</span></span>
 <span><span class="co">#&gt;   <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>                   <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span>             <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span>     <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span></span></span>
-<span><span class="co">#&gt; <span style="color: #BCBCBC;">1</span> ENSE00003483971           128                71        33</span></span>
+<span><span class="co">#&gt; <span style="color: #BCBCBC;">1</span> ENSE00001924953           172                16        19</span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;">2</span> ENSE00001008808           494               257       108</span></span>
-<span><span class="co">#&gt; <span style="color: #BCBCBC;">3</span> ENSE00001924953           172                16        19</span></span></code></pre></div>
+<span><span class="co">#&gt; <span style="color: #BCBCBC;">3</span> ENSE00003483971           128                71        33</span></span></code></pre></div>
 <p>It is perhaps instructive to review the range join as a source of
 inspiration for other computations that might be of interest.</p>
-<div class="sourceCode" id="cb28"><pre class="sourceCode sql"><code class="sourceCode sql"><span id="cb28-1"><a href="#cb28-1" tabindex="-1"></a><span class="co">-- range join of 'hg38' with 'bcl2l11'; overwrite any existing table</span></span>
-<span id="cb28-2"><a href="#cb28-2" tabindex="-1"></a><span class="co">-- 'bcl2l11_overlaps'</span></span>
-<span id="cb28-3"><a href="#cb28-3" tabindex="-1"></a><span class="kw">DROP</span> <span class="kw">TABLE</span> <span class="cf">IF</span> <span class="kw">EXISTS</span> bcl2l11_overlaps;</span>
-<span id="cb28-4"><a href="#cb28-4" tabindex="-1"></a><span class="kw">CREATE</span> TEMP <span class="kw">TABLE</span> bcl2l11_overlaps <span class="kw">AS</span></span>
-<span id="cb28-5"><a href="#cb28-5" tabindex="-1"></a><span class="kw">SELECT</span></span>
-<span id="cb28-6"><a href="#cb28-6" tabindex="-1"></a>    hg38.<span class="op">*</span>,</span>
-<span id="cb28-7"><a href="#cb28-7" tabindex="-1"></a>    bcl2l11.<span class="op">*</span> EXCLUDE (CHROM)</span>
-<span id="cb28-8"><a href="#cb28-8" tabindex="-1"></a><span class="kw">FROM</span> hg38</span>
-<span id="cb28-9"><a href="#cb28-9" tabindex="-1"></a><span class="kw">JOIN</span> bcl2l11</span>
-<span id="cb28-10"><a href="#cb28-10" tabindex="-1"></a>    <span class="kw">ON</span> bcl2l11.CHROM <span class="op">=</span> hg38.CHROM</span>
-<span id="cb28-11"><a href="#cb28-11" tabindex="-1"></a>    <span class="kw">AND</span> bcl2l11.<span class="kw">start</span> <span class="op">&lt;=</span> hg38.POS</span>
-<span id="cb28-12"><a href="#cb28-12" tabindex="-1"></a>    <span class="kw">AND</span> bcl2l11.<span class="cf">end</span> <span class="op">&gt;=</span> hg38.POS;</span></code></pre></div>
+<div class="sourceCode" id="cb26"><pre class="sourceCode sql"><code class="sourceCode sql"><span id="cb26-1"><a href="#cb26-1" tabindex="-1"></a><span class="co">-- range join of 'hg38' with 'bcl2l11'; overwrite any existing table</span></span>
+<span id="cb26-2"><a href="#cb26-2" tabindex="-1"></a><span class="co">-- 'bcl2l11_overlaps'</span></span>
+<span id="cb26-3"><a href="#cb26-3" tabindex="-1"></a><span class="kw">DROP</span> <span class="kw">TABLE</span> <span class="cf">IF</span> <span class="kw">EXISTS</span> bcl2l11_overlaps;</span>
+<span id="cb26-4"><a href="#cb26-4" tabindex="-1"></a><span class="kw">CREATE</span> TEMP <span class="kw">TABLE</span> bcl2l11_overlaps <span class="kw">AS</span></span>
+<span id="cb26-5"><a href="#cb26-5" tabindex="-1"></a><span class="kw">SELECT</span></span>
+<span id="cb26-6"><a href="#cb26-6" tabindex="-1"></a>    hg38.<span class="op">*</span>,</span>
+<span id="cb26-7"><a href="#cb26-7" tabindex="-1"></a>    bcl2l11.<span class="op">*</span> EXCLUDE (CHROM)</span>
+<span id="cb26-8"><a href="#cb26-8" tabindex="-1"></a><span class="kw">FROM</span> hg38</span>
+<span id="cb26-9"><a href="#cb26-9" tabindex="-1"></a><span class="kw">JOIN</span> bcl2l11</span>
+<span id="cb26-10"><a href="#cb26-10" tabindex="-1"></a>    <span class="kw">ON</span> bcl2l11.CHROM <span class="op">=</span> hg38.CHROM</span>
+<span id="cb26-11"><a href="#cb26-11" tabindex="-1"></a>    <span class="kw">AND</span> bcl2l11.<span class="kw">start</span> <span class="op">&lt;=</span> hg38.POS</span>
+<span id="cb26-12"><a href="#cb26-12" tabindex="-1"></a>    <span class="kw">AND</span> bcl2l11.<span class="cf">end</span> <span class="op">&gt;=</span> hg38.POS;</span></code></pre></div>
 <p>As best practice, disconnect from the writable database connection
 when work is complete.</p>
-<div class="sourceCode" id="cb29"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb27"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="../reference/db.html">db_disconnect</a></span><span class="op">(</span><span class="va">db_rw</span><span class="op">)</span></span></code></pre></div>
 </div>
 <div class="section level3">
@@ -560,13 +543,13 @@ <h3 id="from-duckdb-to-bioconductor">From <em>DuckDB</em> to <em>Bioconductor</e
 interested in is <code>"ENST00000393256"</code>.</p>
 <p>Select the relevant variants and, because there are not too many,
 load into <em>R</em>.</p>
-<div class="sourceCode" id="cb30"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb28"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">variants_of_interest</span> <span class="op">&lt;-</span></span>
 <span>    <span class="fu"><a href="../reference/AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"hg38"</span><span class="op">)</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">transcript_id</span> <span class="op">%like%</span> <span class="st">"ENST00000393256%"</span><span class="op">)</span></span></code></pre></div>
 <p>Coerce the AlphaMissense data to a <code>GRanges::GPos</code>
 object.</p>
-<div class="sourceCode" id="cb31"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb29"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">gpos</span> <span class="op">&lt;-</span></span>
 <span>    <span class="va">variants_of_interest</span> <span class="op">|&gt;</span></span>
 <span>    <span class="fu"><a href="../reference/GenomicRanges.html">to_GPos</a></span><span class="op">(</span><span class="op">)</span></span>
@@ -605,7 +588,7 @@ <h3 id="from-duckdb-to-bioconductor">From <em>DuckDB</em> to <em>Bioconductor</e
 <span><span class="co">#&gt;   seqinfo: 25 sequences (1 circular) from GRCh38 genome</span></span></code></pre></div>
 <p>One can then use <a href="https://bioconductor.org/packages/GenomicRanges" class="external-link">GenomicRanges</a>
 functionality, e.g., to count the number of variants in each exon.</p>
-<div class="sourceCode" id="cb32"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb30"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/pkg/IRanges/man/findOverlaps-methods.html" class="external-link">countOverlaps</a></span><span class="op">(</span><span class="fu"><a href="https://rdrr.io/pkg/BiocGenerics/man/unlist.html" class="external-link">unlist</a></span><span class="op">(</span><span class="va">bcl2l11</span><span class="op">)</span>, <span class="va">gpos</span><span class="op">)</span></span>
 <span><span class="co">#&gt; ENST00000393256 ENST00000393256 ENST00000393256 ENST00000393256 </span></span>
 <span><span class="co">#&gt;               0             859             232             207</span></span></code></pre></div>
@@ -616,7 +599,7 @@ <h2 id="finally">Finally<a class="anchor" aria-label="anchor" href="#finally"></
 </h2>
 <p>Remember to disconnect and shutdown all managed DuckDB
 connections.</p>
-<div class="sourceCode" id="cb33"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb31"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="../reference/db.html">db_disconnect_all</a></span><span class="op">(</span><span class="op">)</span></span></code></pre></div>
 <p>Database connections that are not closed correctly trigger warning
 messages.</p>
@@ -624,15 +607,15 @@ <h2 id="finally">Finally<a class="anchor" aria-label="anchor" href="#finally"></
 <div class="section level2">
 <h2 class="unnumbered" id="session-information">Session information<a class="anchor" aria-label="anchor" href="#session-information"></a>
 </h2>
-<div class="sourceCode" id="cb34"><pre class="downlit sourceCode r">
+<div class="sourceCode" id="cb32"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/utils/sessionInfo.html" class="external-link">sessionInfo</a></span><span class="op">(</span><span class="op">)</span></span>
-<span><span class="co">#&gt; R version 4.4.1 Patched (2024-06-20 r86819)</span></span>
-<span><span class="co">#&gt; Platform: aarch64-apple-darwin23.5.0</span></span>
-<span><span class="co">#&gt; Running under: macOS Sonoma 14.5</span></span>
+<span><span class="co">#&gt; R Under development (unstable) (2024-07-31 r86945)</span></span>
+<span><span class="co">#&gt; Platform: aarch64-apple-darwin23.4.0</span></span>
+<span><span class="co">#&gt; Running under: macOS Sonoma 14.6.1</span></span>
 <span><span class="co">#&gt; </span></span>
 <span><span class="co">#&gt; Matrix products: default</span></span>
-<span><span class="co">#&gt; BLAS:   /Users/ma38727/bin/R-4-4-branch/lib/libRblas.dylib </span></span>
-<span><span class="co">#&gt; LAPACK: /Users/ma38727/bin/R-4-4-branch/lib/libRlapack.dylib;  LAPACK version 3.12.0</span></span>
+<span><span class="co">#&gt; BLAS:   /Users/mtmorgan/bin/R-devel/lib/libRblas.dylib </span></span>
+<span><span class="co">#&gt; LAPACK: /Users/mtmorgan/bin/R-devel/lib/libRlapack.dylib;  LAPACK version 3.12.0</span></span>
 <span><span class="co">#&gt; </span></span>
 <span><span class="co">#&gt; locale:</span></span>
 <span><span class="co">#&gt; [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8</span></span>
@@ -645,64 +628,64 @@ <h2 class="unnumbered" id="session-information">Session information<a class="anc
 <span><span class="co">#&gt; [8] base     </span></span>
 <span><span class="co">#&gt; </span></span>
 <span><span class="co">#&gt; other attached packages:</span></span>
-<span><span class="co">#&gt;  [1] ensembldb_2.29.0        AnnotationFilter_1.29.0 GenomicFeatures_1.57.0 </span></span>
-<span><span class="co">#&gt;  [4] AnnotationDbi_1.67.0    Biobase_2.65.0          GenomicRanges_1.57.1   </span></span>
-<span><span class="co">#&gt;  [7] GenomeInfoDb_1.41.1     IRanges_2.39.0          S4Vectors_0.43.0       </span></span>
+<span><span class="co">#&gt;  [1] ensembldb_2.29.1        AnnotationFilter_1.29.0 GenomicFeatures_1.57.0 </span></span>
+<span><span class="co">#&gt;  [4] AnnotationDbi_1.67.0    Biobase_2.65.1          GenomicRanges_1.57.1   </span></span>
+<span><span class="co">#&gt;  [7] GenomeInfoDb_1.41.1     IRanges_2.39.2          S4Vectors_0.43.2       </span></span>
 <span><span class="co">#&gt; [10] BiocGenerics_0.51.0     AlphaMissenseR_1.1.5    dplyr_1.1.4            </span></span>
 <span><span class="co">#&gt; </span></span>
 <span><span class="co">#&gt; loaded via a namespace (and not attached):</span></span>
-<span><span class="co">#&gt;  [1] DBI_1.2.3                   bitops_1.0-7               </span></span>
+<span><span class="co">#&gt;  [1] DBI_1.2.3                   bitops_1.0-8               </span></span>
 <span><span class="co">#&gt;  [3] rlang_1.1.4                 magrittr_2.0.3             </span></span>
-<span><span class="co">#&gt;  [5] matrixStats_1.3.0           compiler_4.4.1             </span></span>
+<span><span class="co">#&gt;  [5] matrixStats_1.3.0           compiler_4.5.0             </span></span>
 <span><span class="co">#&gt;  [7] RSQLite_2.3.7               png_0.1-8                  </span></span>
 <span><span class="co">#&gt;  [9] systemfonts_1.1.0           vctrs_0.6.5                </span></span>
-<span><span class="co">#&gt; [11] ProtGenerics_1.37.0         pkgconfig_2.0.3            </span></span>
+<span><span class="co">#&gt; [11] ProtGenerics_1.37.1         pkgconfig_2.0.3            </span></span>
 <span><span class="co">#&gt; [13] crayon_1.5.3                fastmap_1.2.0              </span></span>
 <span><span class="co">#&gt; [15] dbplyr_2.5.0                XVector_0.45.0             </span></span>
-<span><span class="co">#&gt; [17] utf8_1.2.4                  Rsamtools_2.21.0           </span></span>
-<span><span class="co">#&gt; [19] rmarkdown_2.27              UCSC.utils_1.1.0           </span></span>
+<span><span class="co">#&gt; [17] utf8_1.2.4                  Rsamtools_2.21.1           </span></span>
+<span><span class="co">#&gt; [19] rmarkdown_2.28              UCSC.utils_1.1.0           </span></span>
 <span><span class="co">#&gt; [21] ragg_1.3.2                  purrr_1.0.2                </span></span>
-<span><span class="co">#&gt; [23] bit_4.0.5                   xfun_0.45                  </span></span>
+<span><span class="co">#&gt; [23] bit_4.0.5                   xfun_0.47                  </span></span>
 <span><span class="co">#&gt; [25] zlibbioc_1.51.1             cachem_1.1.0               </span></span>
-<span><span class="co">#&gt; [27] jsonlite_1.8.8              blob_1.2.4                 </span></span>
-<span><span class="co">#&gt; [29] DelayedArray_0.31.3         BiocParallel_1.39.0        </span></span>
-<span><span class="co">#&gt; [31] parallel_4.4.1              spdl_0.0.5                 </span></span>
-<span><span class="co">#&gt; [33] R6_2.5.1                    bslib_0.7.0                </span></span>
+<span><span class="co">#&gt; [27] jsonlite_1.8.9              blob_1.2.4                 </span></span>
+<span><span class="co">#&gt; [29] DelayedArray_0.31.11        BiocParallel_1.39.0        </span></span>
+<span><span class="co">#&gt; [31] parallel_4.5.0              spdl_0.0.5                 </span></span>
+<span><span class="co">#&gt; [33] R6_2.5.1                    bslib_0.8.0                </span></span>
 <span><span class="co">#&gt; [35] rtracklayer_1.65.0          jquerylib_0.1.4            </span></span>
-<span><span class="co">#&gt; [37] Rcpp_1.0.12                 SummarizedExperiment_1.35.0</span></span>
-<span><span class="co">#&gt; [39] knitr_1.47                  BiocBaseUtils_1.7.0        </span></span>
+<span><span class="co">#&gt; [37] Rcpp_1.0.13                 SummarizedExperiment_1.35.1</span></span>
+<span><span class="co">#&gt; [39] knitr_1.48                  BiocBaseUtils_1.7.3        </span></span>
 <span><span class="co">#&gt; [41] Matrix_1.7-0                tidyselect_1.2.1           </span></span>
-<span><span class="co">#&gt; [43] abind_1.4-5                 yaml_2.3.8                 </span></span>
-<span><span class="co">#&gt; [45] codetools_0.2-20            curl_5.2.1                 </span></span>
-<span><span class="co">#&gt; [47] rjsoncons_1.3.0             lattice_0.22-6             </span></span>
-<span><span class="co">#&gt; [49] tibble_3.2.1                withr_3.0.0                </span></span>
+<span><span class="co">#&gt; [43] abind_1.4-5                 yaml_2.3.10                </span></span>
+<span><span class="co">#&gt; [45] codetools_0.2-20            curl_5.2.3                 </span></span>
+<span><span class="co">#&gt; [47] rjsoncons_1.3.1             lattice_0.22-6             </span></span>
+<span><span class="co">#&gt; [49] tibble_3.2.1                withr_3.0.1                </span></span>
 <span><span class="co">#&gt; [51] KEGGREST_1.45.1             evaluate_0.24.0            </span></span>
 <span><span class="co">#&gt; [53] desc_1.4.3                  BiocFileCache_2.13.0       </span></span>
 <span><span class="co">#&gt; [55] Biostrings_2.73.1           pillar_1.9.0               </span></span>
 <span><span class="co">#&gt; [57] BiocManager_1.30.23         filelock_1.0.3             </span></span>
 <span><span class="co">#&gt; [59] MatrixGenerics_1.17.0       whisker_0.4.1              </span></span>
-<span><span class="co">#&gt; [61] generics_0.1.3              RCurl_1.98-1.14            </span></span>
+<span><span class="co">#&gt; [61] generics_0.1.3              RCurl_1.98-1.16            </span></span>
 <span><span class="co">#&gt; [63] BiocVersion_3.20.0          ggplot2_3.5.1              </span></span>
 <span><span class="co">#&gt; [65] munsell_0.5.1               scales_1.3.0               </span></span>
 <span><span class="co">#&gt; [67] glue_1.7.0                  lazyeval_0.2.2             </span></span>
-<span><span class="co">#&gt; [69] tools_4.4.1                 AnnotationHub_3.13.0       </span></span>
-<span><span class="co">#&gt; [71] BiocIO_1.15.0               GenomicAlignments_1.41.0   </span></span>
+<span><span class="co">#&gt; [69] tools_4.5.0                 AnnotationHub_3.13.3       </span></span>
+<span><span class="co">#&gt; [71] BiocIO_1.15.2               GenomicAlignments_1.41.0   </span></span>
 <span><span class="co">#&gt; [73] fs_1.6.4                    XML_3.99-0.17              </span></span>
-<span><span class="co">#&gt; [75] grid_4.4.1                  tidyr_1.3.1                </span></span>
-<span><span class="co">#&gt; [77] colorspace_2.1-0            GenomeInfoDbData_1.2.12    </span></span>
-<span><span class="co">#&gt; [79] RcppSpdlog_0.0.17           duckdb_1.0.0               </span></span>
+<span><span class="co">#&gt; [75] grid_4.5.0                  tidyr_1.3.1                </span></span>
+<span><span class="co">#&gt; [77] colorspace_2.1-1            GenomeInfoDbData_1.2.12    </span></span>
+<span><span class="co">#&gt; [79] RcppSpdlog_0.0.18           duckdb_1.0.0-2             </span></span>
 <span><span class="co">#&gt; [81] restfulr_0.0.15             cli_3.6.3                  </span></span>
 <span><span class="co">#&gt; [83] rappdirs_0.3.3              textshaping_0.4.0          </span></span>
-<span><span class="co">#&gt; [85] fansi_1.0.6                 S4Arrays_1.5.1             </span></span>
+<span><span class="co">#&gt; [85] fansi_1.0.6                 S4Arrays_1.5.7             </span></span>
 <span><span class="co">#&gt; [87] gtable_0.3.5                sass_0.4.9                 </span></span>
-<span><span class="co">#&gt; [89] digest_0.6.36               SparseArray_1.5.10         </span></span>
-<span><span class="co">#&gt; [91] rjson_0.2.21                htmlwidgets_1.6.4          </span></span>
+<span><span class="co">#&gt; [89] digest_0.6.37               SparseArray_1.5.31         </span></span>
+<span><span class="co">#&gt; [91] rjson_0.2.22                htmlwidgets_1.6.4          </span></span>
 <span><span class="co">#&gt; [93] memoise_2.0.1               htmltools_0.5.8.1          </span></span>
-<span><span class="co">#&gt; [95] pkgdown_2.0.9               lifecycle_1.0.4            </span></span>
+<span><span class="co">#&gt; [95] pkgdown_2.1.0               lifecycle_1.0.4            </span></span>
 <span><span class="co">#&gt; [97] httr_1.4.7                  mime_0.12                  </span></span>
 <span><span class="co">#&gt; [99] bit64_4.0.5</span></span></code></pre></div>
 </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside>
 </div>
 
@@ -713,15 +696,15 @@ <h2 class="unnumbered" id="session-information">Session information<a class="anc
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
 </div>
 
     </footer>
 </div>
 
-  
 
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 </html>
diff --git a/articles/issues.html b/articles/issues.html
index 89538cf..04aae92 100644
--- a/articles/issues.html
+++ b/articles/issues.html
@@ -5,67 +5,51 @@
 <meta charset="utf-8">
 <meta http-equiv="X-UA-Compatible" content="IE=edge">
 <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
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+<script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet">
+<link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet">
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+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
 
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       </ul>
-<form class="form-inline my-2 my-lg-0" role="search">
-        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off">
-</form>
-
-      <ul class="navbar-nav">
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="github">
-    <span class="fab fa fab fa-github fa-lg"></span>
-     
-  </a>
-</li>
+<ul class="navbar-nav">
+<li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json">
+</form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
       </ul>
 </div>
 
-    
+
   </div>
 </nav><div class="container template-article">
 
@@ -74,7 +58,8 @@
 
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>D. Issues &amp; Solutions</h1>
+
+      <h1>D. Issues &amp; Solutions</h1>
             
       
       <small class="dont-index">Source: <a href="https://github.com/mtmorgan/AlphaMissenseR/blob/HEAD/vignettes/issues.Rmd" class="external-link"><code>vignettes/issues.Rmd</code></a></small>
@@ -123,7 +108,7 @@ <h2 id="updating-duckdb-to-0-9-1">Updating <a href="https://CRAN.R-project.org/p
 <span>        <span class="fu"><a href="https://rdrr.io/pkg/BiocGenerics/man/grep.html" class="external-link">grepl</a></span><span class="op">(</span><span class="st">"zenodo"</span>, <span class="va">rname</span><span class="op">)</span> <span class="op">|</span></span>
 <span>        <span class="fu"><a href="https://rdrr.io/r/base/startsWith.html" class="external-link">startsWith</a></span><span class="op">(</span><span class="va">rname</span>, <span class="st">"AlphaMissense_"</span><span class="op">)</span></span>
 <span>    <span class="op">)</span> <span class="op">|&gt;</span></span>
-<span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/pull.html" class="external-link">pull</a></span><span class="op">(</span><span class="va">rid</span><span class="op">)</span></span></code></pre></div>
+<span>    <span class="fu">pull</span><span class="op">(</span><span class="va">rid</span><span class="op">)</span></span></code></pre></div>
 <p>After verifying that these resources have not been created outside
 AlphaMissenseR, remove them.</p>
 <div class="sourceCode" id="cb3"><pre class="downlit sourceCode r">
@@ -133,7 +118,7 @@ <h2 id="updating-duckdb-to-0-9-1">Updating <a href="https://CRAN.R-project.org/p
 <div class="sourceCode" id="cb4"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="../reference/AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"gene_hg38"</span><span class="op">)</span></span>
 <span><span class="co">#&gt; <span style="color: #949494;"># Source:   table&lt;gene_hg38&gt; [?? x 2]</span></span></span>
-<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span></span>
+<span><span class="co">#&gt; <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span></span>
 <span><span class="co">#&gt;    transcript_id      mean_am_pathogenicity</span></span>
 <span><span class="co">#&gt;    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>                              <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span></span></span>
 <span><span class="co">#&gt; <span style="color: #BCBCBC;"> 1</span> ENST00000000233.10                 0.742</span></span>
@@ -185,13 +170,13 @@ <h2 class="unnumbered" id="session-information">Session information<a class="anc
 </h2>
 <div class="sourceCode" id="cb7"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="fu"><a href="https://rdrr.io/r/utils/sessionInfo.html" class="external-link">sessionInfo</a></span><span class="op">(</span><span class="op">)</span></span>
-<span><span class="co">#&gt; R version 4.4.1 Patched (2024-06-20 r86819)</span></span>
-<span><span class="co">#&gt; Platform: aarch64-apple-darwin23.5.0</span></span>
-<span><span class="co">#&gt; Running under: macOS Sonoma 14.5</span></span>
+<span><span class="co">#&gt; R Under development (unstable) (2024-07-31 r86945)</span></span>
+<span><span class="co">#&gt; Platform: aarch64-apple-darwin23.4.0</span></span>
+<span><span class="co">#&gt; Running under: macOS Sonoma 14.6.1</span></span>
 <span><span class="co">#&gt; </span></span>
 <span><span class="co">#&gt; Matrix products: default</span></span>
-<span><span class="co">#&gt; BLAS:   /Users/ma38727/bin/R-4-4-branch/lib/libRblas.dylib </span></span>
-<span><span class="co">#&gt; LAPACK: /Users/ma38727/bin/R-4-4-branch/lib/libRlapack.dylib;  LAPACK version 3.12.0</span></span>
+<span><span class="co">#&gt; BLAS:   /Users/mtmorgan/bin/R-devel/lib/libRblas.dylib </span></span>
+<span><span class="co">#&gt; LAPACK: /Users/mtmorgan/bin/R-devel/lib/libRlapack.dylib;  LAPACK version 3.12.0</span></span>
 <span><span class="co">#&gt; </span></span>
 <span><span class="co">#&gt; locale:</span></span>
 <span><span class="co">#&gt; [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8</span></span>
@@ -207,28 +192,28 @@ <h2 class="unnumbered" id="session-information">Session information<a class="anc
 <span><span class="co">#&gt; </span></span>
 <span><span class="co">#&gt; loaded via a namespace (and not attached):</span></span>
 <span><span class="co">#&gt;  [1] sass_0.4.9           utf8_1.2.4           generics_0.1.3      </span></span>
-<span><span class="co">#&gt;  [4] spdl_0.0.5           RSQLite_2.3.7        digest_0.6.36       </span></span>
-<span><span class="co">#&gt;  [7] magrittr_2.0.3       evaluate_0.24.0      grid_4.4.1          </span></span>
-<span><span class="co">#&gt; [10] fastmap_1.2.0        blob_1.2.4           jsonlite_1.8.8      </span></span>
+<span><span class="co">#&gt;  [4] spdl_0.0.5           RSQLite_2.3.7        digest_0.6.37       </span></span>
+<span><span class="co">#&gt;  [7] magrittr_2.0.3       evaluate_0.24.0      grid_4.5.0          </span></span>
+<span><span class="co">#&gt; [10] fastmap_1.2.0        blob_1.2.4           jsonlite_1.8.9      </span></span>
 <span><span class="co">#&gt; [13] whisker_0.4.1        DBI_1.2.3            httr_1.4.7          </span></span>
 <span><span class="co">#&gt; [16] purrr_1.0.2          fansi_1.0.6          scales_1.3.0        </span></span>
-<span><span class="co">#&gt; [19] textshaping_0.4.0    jquerylib_0.1.4      duckdb_1.0.0        </span></span>
+<span><span class="co">#&gt; [19] textshaping_0.4.0    jquerylib_0.1.4      duckdb_1.0.0-2      </span></span>
 <span><span class="co">#&gt; [22] cli_3.6.3            rlang_1.1.4          dbplyr_2.5.0        </span></span>
-<span><span class="co">#&gt; [25] bit64_4.0.5          munsell_0.5.1        withr_3.0.0         </span></span>
-<span><span class="co">#&gt; [28] cachem_1.1.0         yaml_2.3.8           BiocBaseUtils_1.7.0 </span></span>
-<span><span class="co">#&gt; [31] tools_4.4.1          memoise_2.0.1        colorspace_2.1-0    </span></span>
-<span><span class="co">#&gt; [34] ggplot2_3.5.1        filelock_1.0.3       curl_5.2.1          </span></span>
-<span><span class="co">#&gt; [37] rjsoncons_1.3.0      vctrs_0.6.5          R6_2.5.1            </span></span>
-<span><span class="co">#&gt; [40] BiocFileCache_2.13.0 lifecycle_1.0.4      RcppSpdlog_0.0.17   </span></span>
+<span><span class="co">#&gt; [25] munsell_0.5.1        bit64_4.0.5          withr_3.0.1         </span></span>
+<span><span class="co">#&gt; [28] cachem_1.1.0         yaml_2.3.10          BiocBaseUtils_1.7.3 </span></span>
+<span><span class="co">#&gt; [31] tools_4.5.0          memoise_2.0.1        colorspace_2.1-1    </span></span>
+<span><span class="co">#&gt; [34] ggplot2_3.5.1        filelock_1.0.3       curl_5.2.3          </span></span>
+<span><span class="co">#&gt; [37] rjsoncons_1.3.1      vctrs_0.6.5          R6_2.5.1            </span></span>
+<span><span class="co">#&gt; [40] BiocFileCache_2.13.0 lifecycle_1.0.4      RcppSpdlog_0.0.18   </span></span>
 <span><span class="co">#&gt; [43] fs_1.6.4             htmlwidgets_1.6.4    bit_4.0.5           </span></span>
 <span><span class="co">#&gt; [46] ragg_1.3.2           pkgconfig_2.0.3      desc_1.4.3          </span></span>
-<span><span class="co">#&gt; [49] pkgdown_2.0.9        pillar_1.9.0         bslib_0.7.0         </span></span>
-<span><span class="co">#&gt; [52] gtable_0.3.5         Rcpp_1.0.12          glue_1.7.0          </span></span>
-<span><span class="co">#&gt; [55] systemfonts_1.1.0    xfun_0.45            tibble_3.2.1        </span></span>
-<span><span class="co">#&gt; [58] tidyselect_1.2.1     knitr_1.47           htmltools_0.5.8.1   </span></span>
-<span><span class="co">#&gt; [61] rmarkdown_2.27       compiler_4.4.1</span></span></code></pre></div>
+<span><span class="co">#&gt; [49] pkgdown_2.1.0        pillar_1.9.0         bslib_0.8.0         </span></span>
+<span><span class="co">#&gt; [52] gtable_0.3.5         Rcpp_1.0.13          glue_1.7.0          </span></span>
+<span><span class="co">#&gt; [55] systemfonts_1.1.0    xfun_0.47            tibble_3.2.1        </span></span>
+<span><span class="co">#&gt; [58] tidyselect_1.2.1     knitr_1.48           htmltools_0.5.8.1   </span></span>
+<span><span class="co">#&gt; [61] rmarkdown_2.28       compiler_4.5.0</span></span></code></pre></div>
 </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside>
 </div>
 
@@ -239,15 +224,15 @@ <h2 class="unnumbered" id="session-information">Session information<a class="anc
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
 </div>
 
     </footer>
 </div>
 
-  
 
-  
+
+
 
   </body>
 </html>
diff --git a/authors.html b/authors.html
index 24fdfda..90bfa40 100644
--- a/authors.html
+++ b/authors.html
@@ -1,103 +1,98 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Authors and Citation • AlphaMissenseR</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Authors and Citation"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
-<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
-<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]--></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Authors and Citation • AlphaMissenseR</title><script src="deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="deps/headroom-0.11.0/headroom.min.js"></script><script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="deps/search-1.0.0/fuse.min.js"></script><script src="deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="pkgdown.js"></script><meta property="og:title" content="Authors and Citation"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
-    
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light" data-bs-theme="light"><div class="container">
-    
+
+    <nav class="navbar navbar-expand-lg fixed-top bg-light" data-bs-theme="light" aria-label="Site navigation"><div class="container">
+
     <a class="navbar-brand me-2" href="index.html">AlphaMissenseR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.5</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
 
-    
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
       <span class="navbar-toggler-icon"></span>
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-      <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="reference/index.html">Reference</a>
-</li>
+      <ul class="navbar-nav me-auto"><li class="nav-item"><a class="nav-link" href="reference/index.html">Reference</a></li>
 <li class="nav-item dropdown">
-  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
-  <div class="dropdown-menu" aria-labelledby="dropdown-articles">
-    <a class="dropdown-item" href="articles/introduction.html">A. Introduction</a>
-    <a class="dropdown-item" href="articles/alphafold.html">B. AlphaFold Integration</a>
-    <a class="dropdown-item" href="articles/clinvar.html">C. ClinVar Integration</a>
-    <a class="dropdown-item" href="articles/issues.html">D. Issues &amp; Solutions</a>
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-</li>
-<li class="nav-item">
-  <a class="nav-link" href="news/index.html">Changelog</a>
-</li>
-      </ul><form class="form-inline my-2 my-lg-0" role="search">
-        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
-
-      <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="github">
-    <span class="fab fa fab fa-github fa-lg"></span>
-     
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-</li>
+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles"><li><a class="dropdown-item" href="articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="articles/issues.html">D. Issues &amp; Solutions</a></li>
+  </ul></li>
+<li class="nav-item"><a class="nav-link" href="news/index.html">Changelog</a></li>
+      </ul><ul class="navbar-nav"><li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="search.json"></form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
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 </nav><div class="container template-citation-authors">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>Authors and Citation</h1>
+
+      <h1>Authors and Citation</h1>
     </div>
 
-    <div class="section level2 citation">
+    <div class="section level2">
       <h2>Authors</h2>
-      
+
       <ul class="list-unstyled"><li>
           <p><strong>Martin Morgan</strong>. Author, maintainer. <a href="https://orcid.org/0000-0002-5874-8148" target="orcid.widget" aria-label="ORCID" class="external-link"><span class="fab fa-orcid orcid" aria-hidden="true"></span></a>
           </p>
         </li>
         <li>
-          <p><strong>Tram Nguyen</strong>. Author. 
+          <p><strong>Tram Nguyen</strong>. Author.
+          </p>
+        </li>
+        <li>
+          <p><strong>Tyrone Lee</strong>. Contributor.
+          </p>
+        </li>
+        <li>
+          <p><strong>Nitesh Turaga</strong>. Contributor.
           </p>
         </li>
         <li>
-          <p><strong>Chan Zuckerberg Initiative DAF CZF2019-002443</strong>. Funder. 
+          <p><strong>Chan Zuckerberg Initiative DAF CZF2019-002443</strong>. Funder.
           </p>
         </li>
         <li>
-          <p><strong>NIH NCI ITCR U24CA180996</strong>. Funder. 
+          <p><strong>NIH NCI ITCR U24CA180996</strong>. Funder.
           </p>
         </li>
         <li>
-          <p><strong>NIH NCI IOTN U24CA232979</strong>. Funder. 
+          <p><strong>NIH NCI IOTN U24CA232979</strong>. Funder.
           </p>
         </li>
         <li>
-          <p><strong>NIH NCI ARTNet U24CA274159</strong>. Funder. 
+          <p><strong>NIH NCI ARTNet U24CA274159</strong>. Funder.
           </p>
         </li>
       </ul></div>
 
-    <div class="section level2 citation">
+    <div class="section level2">
       <h2 id="citation">Citation</h2>
       <p><small class="dont-index">Source: <a href="https://github.com/mtmorgan/AlphaMissenseR/blob/HEAD/DESCRIPTION" class="external-link"><code>DESCRIPTION</code></a></small></p>
 
       <p>Morgan M, Nguyen T (2024).
 <em>AlphaMissenseR: Accessing AlphaMissense Data Resources in R</em>.
-R package version 1.1.5, <a href="https://mtmorgan.github.io/AlphaMissenseR/">https://mtmorgan.github.io/AlphaMissenseR/</a>. 
+R package version 1.1.6, <a href="https://mtmorgan.github.io/AlphaMissenseR/">https://mtmorgan.github.io/AlphaMissenseR/</a>.
 </p>
       <pre>@Manual{,
   title = {AlphaMissenseR: Accessing AlphaMissense Data Resources in R},
   author = {Martin Morgan and Tram Nguyen},
   year = {2024},
-  note = {R package version 1.1.5},
+  note = {R package version 1.1.6},
   url = {https://mtmorgan.github.io/AlphaMissenseR/},
 }</pre>
     </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside></div>
 
 
@@ -106,14 +101,14 @@ <h2 id="citation">Citation</h2>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
 </div>
 
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diff --git a/deps/bootstrap-5.3.1/bootstrap.min.css b/deps/bootstrap-5.3.1/bootstrap.min.css
index d944a2a..5d96aa0 100644
--- a/deps/bootstrap-5.3.1/bootstrap.min.css
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#212529;--bs-btn-border-color: #212529;--bs-btn-hover-color: #fff;--bs-btn-hover-bg: #424649;--bs-btn-hover-border-color: #373b3e;--bs-btn-focus-shadow-rgb: 66,70,73;--bs-btn-active-color: #fff;--bs-btn-active-bg: #4d5154;--bs-btn-active-border-color: #373b3e;--bs-btn-active-shadow: inset 0 3px 5px rgba(0,0,0,0.125);--bs-btn-disabled-color: #fff;--bs-btn-disabled-bg: #212529;--bs-btn-disabled-border-color: #212529}.btn-outline-default{--bs-btn-color: #dee2e6;--bs-btn-border-color: #dee2e6;--bs-btn-hover-color: #000;--bs-btn-hover-bg: #dee2e6;--bs-btn-hover-border-color: #dee2e6;--bs-btn-focus-shadow-rgb: 222,226,230;--bs-btn-active-color: #000;--bs-btn-active-bg: #dee2e6;--bs-btn-active-border-color: #dee2e6;--bs-btn-active-shadow: inset 0 3px 5px rgba(0,0,0,0.125);--bs-btn-disabled-color: #dee2e6;--bs-btn-disabled-bg: transparent;--bs-btn-disabled-border-color: #dee2e6;--bs-btn-bg: transparent;--bs-gradient: none}.btn-outline-primary{--bs-btn-color: #0d6efd;--bs-btn-border-color: 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transparent;--bs-gradient: none}.btn-outline-light{--bs-btn-color: #f8f9fa;--bs-btn-border-color: #f8f9fa;--bs-btn-hover-color: #000;--bs-btn-hover-bg: #f8f9fa;--bs-btn-hover-border-color: #f8f9fa;--bs-btn-focus-shadow-rgb: 248,249,250;--bs-btn-active-color: #000;--bs-btn-active-bg: #f8f9fa;--bs-btn-active-border-color: #f8f9fa;--bs-btn-active-shadow: inset 0 3px 5px rgba(0,0,0,0.125);--bs-btn-disabled-color: #f8f9fa;--bs-btn-disabled-bg: transparent;--bs-btn-disabled-border-color: #f8f9fa;--bs-btn-bg: transparent;--bs-gradient: none}.btn-outline-dark{--bs-btn-color: #212529;--bs-btn-border-color: #212529;--bs-btn-hover-color: #fff;--bs-btn-hover-bg: #212529;--bs-btn-hover-border-color: #212529;--bs-btn-focus-shadow-rgb: 33,37,41;--bs-btn-active-color: #fff;--bs-btn-active-bg: #212529;--bs-btn-active-border-color: #212529;--bs-btn-active-shadow: inset 0 3px 5px rgba(0,0,0,0.125);--bs-btn-disabled-color: #212529;--bs-btn-disabled-bg: transparent;--bs-btn-disabled-border-color: #212529;--bs-btn-bg: transparent;--bs-gradient: none}.btn-link{--bs-btn-font-weight: 400;--bs-btn-color: var(--bs-link-color);--bs-btn-bg: transparent;--bs-btn-border-color: transparent;--bs-btn-hover-color: var(--bs-link-hover-color);--bs-btn-hover-border-color: transparent;--bs-btn-active-color: var(--bs-link-hover-color);--bs-btn-active-border-color: transparent;--bs-btn-disabled-color: #6c757d;--bs-btn-disabled-border-color: transparent;--bs-btn-box-shadow: 0 0 0 #000;--bs-btn-focus-shadow-rgb: 49,132,253;text-decoration:underline;-webkit-text-decoration:underline;-moz-text-decoration:underline;-ms-text-decoration:underline;-o-text-decoration:underline}.btn-link:focus-visible{color:var(--bs-btn-color)}.btn-link:hover{color:var(--bs-btn-hover-color)}.btn-lg,.btn-group-lg>.btn{--bs-btn-padding-y: .5rem;--bs-btn-padding-x: 1rem;--bs-btn-font-size:1.25rem;--bs-btn-border-radius: var(--bs-border-radius-lg)}.btn-sm,.btn-group-sm>.btn{--bs-btn-padding-y: .25rem;--bs-btn-padding-x: 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auto}.btn-group>.btn-check:checked+.btn,.btn-group>.btn-check:focus+.btn,.btn-group>.btn:hover,.btn-group>.btn:focus,.btn-group>.btn:active,.btn-group>.btn.active,.btn-group-vertical>.btn-check:checked+.btn,.btn-group-vertical>.btn-check:focus+.btn,.btn-group-vertical>.btn:hover,.btn-group-vertical>.btn:focus,.btn-group-vertical>.btn:active,.btn-group-vertical>.btn.active{z-index:1}.btn-toolbar{display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;justify-content:flex-start;-webkit-justify-content:flex-start}.btn-toolbar .input-group{width:auto}.btn-group{border-radius:var(--bs-border-radius)}.btn-group>:not(.btn-check:first-child)+.btn,.btn-group>.btn-group:not(:first-child){margin-left:calc(var(--bs-border-width) * -1)}.btn-group>.btn:not(:last-child):not(.dropdown-toggle),.btn-group>.btn.dropdown-toggle-split:first-child,.btn-group>.btn-group:not(:last-child)>.btn{border-top-right-radius:0;border-bottom-right-radius:0}.btn-group>.btn:nth-child(n + 3),.btn-group>:not(.btn-check)+.btn,.btn-group>.btn-group:not(:first-child)>.btn{border-top-left-radius:0;border-bottom-left-radius:0}.dropdown-toggle-split{padding-right:.5625rem;padding-left:.5625rem}.dropdown-toggle-split::after,.dropup .dropdown-toggle-split::after,.dropend .dropdown-toggle-split::after{margin-left:0}.dropstart .dropdown-toggle-split::before{margin-right:0}.btn-sm+.dropdown-toggle-split,.btn-group-sm>.btn+.dropdown-toggle-split{padding-right:.375rem;padding-left:.375rem}.btn-lg+.dropdown-toggle-split,.btn-group-lg>.btn+.dropdown-toggle-split{padding-right:.75rem;padding-left:.75rem}.btn-group-vertical{flex-direction:column;-webkit-flex-direction:column;align-items:flex-start;-webkit-align-items:flex-start;justify-content:center;-webkit-justify-content:center}.btn-group-vertical>.btn,.btn-group-vertical>.btn-group{width:100%}.btn-group-vertical>.btn:not(:first-child),.btn-group-vertical>.btn-group:not(:first-child){margin-top:calc(var(--bs-border-width) * -1)}.btn-group-vertical>.btn:not(:last-child):not(.dropdown-toggle),.btn-group-vertical>.btn-group:not(:last-child)>.btn{border-bottom-right-radius:0;border-bottom-left-radius:0}.btn-group-vertical>.btn~.btn,.btn-group-vertical>.btn-group:not(:first-child)>.btn{border-top-left-radius:0;border-top-right-radius:0}.nav{--bs-nav-link-padding-x: 1rem;--bs-nav-link-padding-y: .5rem;--bs-nav-link-font-weight: ;--bs-nav-link-color: var(--bs-link-color);--bs-nav-link-hover-color: var(--bs-link-hover-color);--bs-nav-link-disabled-color: var(--bs-secondary-color);display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;padding-left:0;margin-bottom:0;list-style:none}.nav-link{display:block;padding:var(--bs-nav-link-padding-y) 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url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23052c65'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-focus-border-color: #86b7fe;--bs-accordion-btn-focus-box-shadow: 0 0 0 .25rem rgba(13,110,253,0.25);--bs-accordion-body-padding-x: 1.25rem;--bs-accordion-body-padding-y: 1rem;--bs-accordion-active-color: var(--bs-primary-text-emphasis);--bs-accordion-active-bg: var(--bs-primary-bg-subtle)}.accordion-button{position:relative;display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;width:100%;padding:var(--bs-accordion-btn-padding-y) var(--bs-accordion-btn-padding-x);font-size:1rem;color:var(--bs-accordion-btn-color);text-align:left;background-color:var(--bs-accordion-btn-bg);border:0;border-radius:0;overflow-anchor:none;transition:var(--bs-accordion-transition)}@media 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reduce){.accordion-button::after{transition:none}}.accordion-button:hover{z-index:2}.accordion-button:focus{z-index:3;border-color:var(--bs-accordion-btn-focus-border-color);outline:0;box-shadow:var(--bs-accordion-btn-focus-box-shadow)}.accordion-header{margin-bottom:0}.accordion-item{color:var(--bs-accordion-color);background-color:var(--bs-accordion-bg);border:var(--bs-accordion-border-width) solid var(--bs-accordion-border-color)}.accordion-item:first-of-type{border-top-left-radius:var(--bs-accordion-border-radius);border-top-right-radius:var(--bs-accordion-border-radius)}.accordion-item:first-of-type .accordion-button{border-top-left-radius:var(--bs-accordion-inner-border-radius);border-top-right-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:not(:first-of-type){border-top:0}.accordion-item:last-of-type{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-item:last-of-type .accordion-button.collapsed{border-bottom-right-radius:var(--bs-accordion-inner-border-radius);border-bottom-left-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:last-of-type .accordion-collapse{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-body{padding:var(--bs-accordion-body-padding-y) var(--bs-accordion-body-padding-x)}.accordion-flush .accordion-collapse{border-width:0}.accordion-flush .accordion-item{border-right:0;border-left:0;border-radius:0}.accordion-flush .accordion-item:first-child{border-top:0}.accordion-flush .accordion-item:last-child{border-bottom:0}.accordion-flush .accordion-item .accordion-button,.accordion-flush .accordion-item .accordion-button.collapsed{border-radius:0}[data-bs-theme="dark"] .accordion-button::after{--bs-accordion-btn-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%236ea8fe'%3e%3cpath 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var(--bs-breadcrumb-padding-x);margin-bottom:var(--bs-breadcrumb-margin-bottom);font-size:var(--bs-breadcrumb-font-size);list-style:none;background-color:var(--bs-breadcrumb-bg);border-radius:var(--bs-breadcrumb-border-radius)}.breadcrumb-item+.breadcrumb-item{padding-left:var(--bs-breadcrumb-item-padding-x)}.breadcrumb-item+.breadcrumb-item::before{float:left;padding-right:var(--bs-breadcrumb-item-padding-x);color:var(--bs-breadcrumb-divider-color);content:var(--bs-breadcrumb-divider, "/") /* rtl: var(--bs-breadcrumb-divider, "/") */}.breadcrumb-item.active{color:var(--bs-breadcrumb-item-active-color)}.pagination{--bs-pagination-padding-x: .75rem;--bs-pagination-padding-y: .375rem;--bs-pagination-font-size:1rem;--bs-pagination-color: var(--bs-link-color);--bs-pagination-bg: var(--bs-body-bg);--bs-pagination-border-width: var(--bs-border-width);--bs-pagination-border-color: var(--bs-border-color);--bs-pagination-border-radius: var(--bs-border-radius);--bs-pagination-hover-color: var(--bs-link-hover-color);--bs-pagination-hover-bg: var(--bs-tertiary-bg);--bs-pagination-hover-border-color: var(--bs-border-color);--bs-pagination-focus-color: var(--bs-link-hover-color);--bs-pagination-focus-bg: var(--bs-secondary-bg);--bs-pagination-focus-box-shadow: 0 0 0 .25rem rgba(13,110,253,0.25);--bs-pagination-active-color: #fff;--bs-pagination-active-bg: #0d6efd;--bs-pagination-active-border-color: #0d6efd;--bs-pagination-disabled-color: var(--bs-secondary-color);--bs-pagination-disabled-bg: var(--bs-secondary-bg);--bs-pagination-disabled-border-color: var(--bs-border-color);display:flex;display:-webkit-flex;padding-left:0;list-style:none}.page-link{position:relative;display:block;padding:var(--bs-pagination-padding-y) var(--bs-pagination-padding-x);font-size:var(--bs-pagination-font-size);color:var(--bs-pagination-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-pagination-bg);border:var(--bs-pagination-border-width) solid var(--bs-pagination-border-color);transition:color 0.15s ease-in-out,background-color 0.15s ease-in-out,border-color 0.15s ease-in-out,box-shadow 0.15s ease-in-out}@media (prefers-reduced-motion: reduce){.page-link{transition:none}}.page-link:hover{z-index:2;color:var(--bs-pagination-hover-color);background-color:var(--bs-pagination-hover-bg);border-color:var(--bs-pagination-hover-border-color)}.page-link:focus{z-index:3;color:var(--bs-pagination-focus-color);background-color:var(--bs-pagination-focus-bg);outline:0;box-shadow:var(--bs-pagination-focus-box-shadow)}.page-link.active,.active>.page-link{z-index:3;color:var(--bs-pagination-active-color);background-color:var(--bs-pagination-active-bg);border-color:var(--bs-pagination-active-border-color)}.page-link.disabled,.disabled>.page-link{color:var(--bs-pagination-disabled-color);pointer-events:none;background-color:var(--bs-pagination-disabled-bg);border-color:var(--bs-pagination-disabled-border-color)}.page-item:not(:first-child) .page-link{margin-left:calc(var(--bs-border-width) * -1)}.page-item:first-child .page-link{border-top-left-radius:var(--bs-pagination-border-radius);border-bottom-left-radius:var(--bs-pagination-border-radius)}.page-item:last-child .page-link{border-top-right-radius:var(--bs-pagination-border-radius);border-bottom-right-radius:var(--bs-pagination-border-radius)}.pagination-lg{--bs-pagination-padding-x: 1.5rem;--bs-pagination-padding-y: .75rem;--bs-pagination-font-size:1.25rem;--bs-pagination-border-radius: var(--bs-border-radius-lg)}.pagination-sm{--bs-pagination-padding-x: .5rem;--bs-pagination-padding-y: .25rem;--bs-pagination-font-size:.875rem;--bs-pagination-border-radius: var(--bs-border-radius-sm)}.badge{--bs-badge-padding-x: .65em;--bs-badge-padding-y: .35em;--bs-badge-font-size:.75em;--bs-badge-font-weight: 700;--bs-badge-color: #fff;--bs-badge-border-radius: var(--bs-border-radius);display:inline-block;padding:var(--bs-badge-padding-y) var(--bs-badge-padding-x);font-size:var(--bs-badge-font-size);font-weight:var(--bs-badge-font-weight);line-height:1;color:var(--bs-badge-color);text-align:center;white-space:nowrap;vertical-align:baseline;border-radius:var(--bs-badge-border-radius)}.badge:empty{display:none}.btn .badge{position:relative;top:-1px}.alert{--bs-alert-bg: transparent;--bs-alert-padding-x: 1rem;--bs-alert-padding-y: 1rem;--bs-alert-margin-bottom: 1rem;--bs-alert-color: inherit;--bs-alert-border-color: transparent;--bs-alert-border: var(--bs-border-width) solid var(--bs-alert-border-color);--bs-alert-border-radius: var(--bs-border-radius);--bs-alert-link-color: inherit;position:relative;padding:var(--bs-alert-padding-y) var(--bs-alert-padding-x);margin-bottom:var(--bs-alert-margin-bottom);color:var(--bs-alert-color);background-color:var(--bs-alert-bg);border:var(--bs-alert-border);border-radius:var(--bs-alert-border-radius)}.alert-heading{color:inherit}.alert-link{font-weight:700;color:var(--bs-alert-link-color)}.alert-dismissible{padding-right:3rem}.alert-dismissible .btn-close{position:absolute;top:0;right:0;z-index:2;padding:1.25rem 1rem}.alert-default{--bs-alert-color: var(--bs-default-text-emphasis);--bs-alert-bg: var(--bs-default-bg-subtle);--bs-alert-border-color: var(--bs-default-border-subtle);--bs-alert-link-color: var(--bs-default-text-emphasis)}.alert-primary{--bs-alert-color: var(--bs-primary-text-emphasis);--bs-alert-bg: var(--bs-primary-bg-subtle);--bs-alert-border-color: var(--bs-primary-border-subtle);--bs-alert-link-color: var(--bs-primary-text-emphasis)}.alert-secondary{--bs-alert-color: var(--bs-secondary-text-emphasis);--bs-alert-bg: var(--bs-secondary-bg-subtle);--bs-alert-border-color: var(--bs-secondary-border-subtle);--bs-alert-link-color: var(--bs-secondary-text-emphasis)}.alert-success{--bs-alert-color: var(--bs-success-text-emphasis);--bs-alert-bg: var(--bs-success-bg-subtle);--bs-alert-border-color: var(--bs-success-border-subtle);--bs-alert-link-color: var(--bs-success-text-emphasis)}.alert-info{--bs-alert-color: var(--bs-info-text-emphasis);--bs-alert-bg: var(--bs-info-bg-subtle);--bs-alert-border-color: var(--bs-info-border-subtle);--bs-alert-link-color: var(--bs-info-text-emphasis)}.alert-warning{--bs-alert-color: var(--bs-warning-text-emphasis);--bs-alert-bg: var(--bs-warning-bg-subtle);--bs-alert-border-color: var(--bs-warning-border-subtle);--bs-alert-link-color: var(--bs-warning-text-emphasis)}.alert-danger{--bs-alert-color: var(--bs-danger-text-emphasis);--bs-alert-bg: var(--bs-danger-bg-subtle);--bs-alert-border-color: var(--bs-danger-border-subtle);--bs-alert-link-color: var(--bs-danger-text-emphasis)}.alert-light{--bs-alert-color: var(--bs-light-text-emphasis);--bs-alert-bg: var(--bs-light-bg-subtle);--bs-alert-border-color: var(--bs-light-border-subtle);--bs-alert-link-color: var(--bs-light-text-emphasis)}.alert-dark{--bs-alert-color: var(--bs-dark-text-emphasis);--bs-alert-bg: var(--bs-dark-bg-subtle);--bs-alert-border-color: var(--bs-dark-border-subtle);--bs-alert-link-color: var(--bs-dark-text-emphasis)}@keyframes progress-bar-stripes{0%{background-position-x:1rem}}.progress,.progress-stacked{--bs-progress-height: 1rem;--bs-progress-font-size:.75rem;--bs-progress-bg: var(--bs-secondary-bg);--bs-progress-border-radius: var(--bs-border-radius);--bs-progress-box-shadow: var(--bs-box-shadow-inset);--bs-progress-bar-color: #fff;--bs-progress-bar-bg: #0d6efd;--bs-progress-bar-transition: width 0.6s ease;display:flex;display:-webkit-flex;height:var(--bs-progress-height);overflow:hidden;font-size:var(--bs-progress-font-size);background-color:var(--bs-progress-bg);border-radius:var(--bs-progress-border-radius)}.progress-bar{display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;justify-content:center;-webkit-justify-content:center;overflow:hidden;color:var(--bs-progress-bar-color);text-align:center;white-space:nowrap;background-color:var(--bs-progress-bar-bg);transition:var(--bs-progress-bar-transition)}@media (prefers-reduced-motion: reduce){.progress-bar{transition:none}}.progress-bar-striped{background-image:linear-gradient(45deg, rgba(255,255,255,0.15) 25%, transparent 25%, transparent 50%, rgba(255,255,255,0.15) 50%, rgba(255,255,255,0.15) 75%, transparent 75%, transparent);background-size:var(--bs-progress-height) var(--bs-progress-height)}.progress-stacked>.progress{overflow:visible}.progress-stacked>.progress>.progress-bar{width:100%}.progress-bar-animated{animation:1s linear infinite progress-bar-stripes}@media (prefers-reduced-motion: reduce){.progress-bar-animated{animation:none}}.list-group{--bs-list-group-color: var(--bs-body-color);--bs-list-group-bg: var(--bs-body-bg);--bs-list-group-border-color: var(--bs-border-color);--bs-list-group-border-width: var(--bs-border-width);--bs-list-group-border-radius: var(--bs-border-radius);--bs-list-group-item-padding-x: 1rem;--bs-list-group-item-padding-y: .5rem;--bs-list-group-action-color: var(--bs-secondary-color);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-tertiary-bg);--bs-list-group-action-active-color: var(--bs-body-color);--bs-list-group-action-active-bg: var(--bs-secondary-bg);--bs-list-group-disabled-color: var(--bs-secondary-color);--bs-list-group-disabled-bg: var(--bs-body-bg);--bs-list-group-active-color: #fff;--bs-list-group-active-bg: #0d6efd;--bs-list-group-active-border-color: #0d6efd;display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;padding-left:0;margin-bottom:0;border-radius:var(--bs-list-group-border-radius)}.list-group-numbered{list-style-type:none;counter-reset:section}.list-group-numbered>.list-group-item::before{content:counters(section, ".") ". ";counter-increment:section}.list-group-item-action{width:100%;color:var(--bs-list-group-action-color);text-align:inherit}.list-group-item-action:hover,.list-group-item-action:focus{z-index:1;color:var(--bs-list-group-action-hover-color);text-decoration:none;background-color:var(--bs-list-group-action-hover-bg)}.list-group-item-action:active{color:var(--bs-list-group-action-active-color);background-color:var(--bs-list-group-action-active-bg)}.list-group-item{position:relative;display:block;padding:var(--bs-list-group-item-padding-y) var(--bs-list-group-item-padding-x);color:var(--bs-list-group-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-list-group-bg);border:var(--bs-list-group-border-width) solid var(--bs-list-group-border-color)}.list-group-item:first-child{border-top-left-radius:inherit;border-top-right-radius:inherit}.list-group-item:last-child{border-bottom-right-radius:inherit;border-bottom-left-radius:inherit}.list-group-item.disabled,.list-group-item:disabled{color:var(--bs-list-group-disabled-color);pointer-events:none;background-color:var(--bs-list-group-disabled-bg)}.list-group-item.active{z-index:2;color:var(--bs-list-group-active-color);background-color:var(--bs-list-group-active-bg);border-color:var(--bs-list-group-active-border-color)}.list-group-item+.list-group-item{border-top-width:0}.list-group-item+.list-group-item.active{margin-top:calc(-1 * var(--bs-list-group-border-width));border-top-width:var(--bs-list-group-border-width)}.list-group-horizontal{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal>.list-group-item.active{margin-top:0}.list-group-horizontal>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}@media (min-width: 576px){.list-group-horizontal-sm{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-sm>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-sm>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-sm>.list-group-item.active{margin-top:0}.list-group-horizontal-sm>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-sm>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 768px){.list-group-horizontal-md{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-md>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-md>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-md>.list-group-item.active{margin-top:0}.list-group-horizontal-md>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-md>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 992px){.list-group-horizontal-lg{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-lg>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-lg>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-lg>.list-group-item.active{margin-top:0}.list-group-horizontal-lg>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-lg>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 1200px){.list-group-horizontal-xl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xl>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-xl>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-xl>.list-group-item.active{margin-top:0}.list-group-horizontal-xl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xl>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 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var(--bs-list-group-border-width)}.list-group-flush>.list-group-item:last-child{border-bottom-width:0}.list-group-item-default{--bs-list-group-color: var(--bs-default-text-emphasis);--bs-list-group-bg: var(--bs-default-bg-subtle);--bs-list-group-border-color: var(--bs-default-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-default-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-default-border-subtle);--bs-list-group-active-color: var(--bs-default-bg-subtle);--bs-list-group-active-bg: var(--bs-default-text-emphasis);--bs-list-group-active-border-color: var(--bs-default-text-emphasis)}.list-group-item-primary{--bs-list-group-color: var(--bs-primary-text-emphasis);--bs-list-group-bg: var(--bs-primary-bg-subtle);--bs-list-group-border-color: var(--bs-primary-border-subtle);--bs-list-group-action-hover-color: 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var(--bs-secondary-text-emphasis);--bs-list-group-active-border-color: var(--bs-secondary-text-emphasis)}.list-group-item-success{--bs-list-group-color: var(--bs-success-text-emphasis);--bs-list-group-bg: var(--bs-success-bg-subtle);--bs-list-group-border-color: var(--bs-success-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-success-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-success-border-subtle);--bs-list-group-active-color: var(--bs-success-bg-subtle);--bs-list-group-active-bg: var(--bs-success-text-emphasis);--bs-list-group-active-border-color: var(--bs-success-text-emphasis)}.list-group-item-info{--bs-list-group-color: var(--bs-info-text-emphasis);--bs-list-group-bg: var(--bs-info-bg-subtle);--bs-list-group-border-color: var(--bs-info-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-info-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-info-border-subtle);--bs-list-group-active-color: var(--bs-info-bg-subtle);--bs-list-group-active-bg: var(--bs-info-text-emphasis);--bs-list-group-active-border-color: var(--bs-info-text-emphasis)}.list-group-item-warning{--bs-list-group-color: var(--bs-warning-text-emphasis);--bs-list-group-bg: var(--bs-warning-bg-subtle);--bs-list-group-border-color: var(--bs-warning-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-warning-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-warning-border-subtle);--bs-list-group-active-color: var(--bs-warning-bg-subtle);--bs-list-group-active-bg: var(--bs-warning-text-emphasis);--bs-list-group-active-border-color: var(--bs-warning-text-emphasis)}.list-group-item-danger{--bs-list-group-color: var(--bs-danger-text-emphasis);--bs-list-group-bg: var(--bs-danger-bg-subtle);--bs-list-group-border-color: var(--bs-danger-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-danger-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-danger-border-subtle);--bs-list-group-active-color: var(--bs-danger-bg-subtle);--bs-list-group-active-bg: var(--bs-danger-text-emphasis);--bs-list-group-active-border-color: var(--bs-danger-text-emphasis)}.list-group-item-light{--bs-list-group-color: var(--bs-light-text-emphasis);--bs-list-group-bg: var(--bs-light-bg-subtle);--bs-list-group-border-color: var(--bs-light-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-light-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-light-border-subtle);--bs-list-group-active-color: var(--bs-light-bg-subtle);--bs-list-group-active-bg: var(--bs-light-text-emphasis);--bs-list-group-active-border-color: var(--bs-light-text-emphasis)}.list-group-item-dark{--bs-list-group-color: var(--bs-dark-text-emphasis);--bs-list-group-bg: var(--bs-dark-bg-subtle);--bs-list-group-border-color: var(--bs-dark-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-dark-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-dark-border-subtle);--bs-list-group-active-color: var(--bs-dark-bg-subtle);--bs-list-group-active-bg: var(--bs-dark-text-emphasis);--bs-list-group-active-border-color: var(--bs-dark-text-emphasis)}.btn-close{--bs-btn-close-color: #000;--bs-btn-close-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' 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-1)}.btn-group-vertical>.btn:not(:last-child):not(.dropdown-toggle),.btn-group-vertical>.btn-group:not(:last-child)>.btn{border-bottom-right-radius:0;border-bottom-left-radius:0}.btn-group-vertical>.btn~.btn,.btn-group-vertical>.btn-group:not(:first-child)>.btn{border-top-left-radius:0;border-top-right-radius:0}.nav{--bs-nav-link-padding-x: 1rem;--bs-nav-link-padding-y: .5rem;--bs-nav-link-font-weight: ;--bs-nav-link-color: var(--bs-link-color);--bs-nav-link-hover-color: var(--bs-link-hover-color);--bs-nav-link-disabled-color: var(--bs-secondary-color);display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;padding-left:0;margin-bottom:0;list-style:none}.nav-link{display:block;padding:var(--bs-nav-link-padding-y) 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var(--bs-border-color);--bs-nav-tabs-link-active-color: var(--bs-emphasis-color);--bs-nav-tabs-link-active-bg: var(--bs-body-bg);--bs-nav-tabs-link-active-border-color: var(--bs-border-color) var(--bs-border-color) var(--bs-body-bg);border-bottom:var(--bs-nav-tabs-border-width) solid var(--bs-nav-tabs-border-color)}.nav-tabs .nav-link{margin-bottom:calc(-1 * var(--bs-nav-tabs-border-width));border:var(--bs-nav-tabs-border-width) solid transparent;border-top-left-radius:var(--bs-nav-tabs-border-radius);border-top-right-radius:var(--bs-nav-tabs-border-radius)}.nav-tabs .nav-link:hover,.nav-tabs .nav-link:focus{isolation:isolate;border-color:var(--bs-nav-tabs-link-hover-border-color)}.nav-tabs .nav-link.active,.nav-tabs .nav-item.show .nav-link{color:var(--bs-nav-tabs-link-active-color);background-color:var(--bs-nav-tabs-link-active-bg);border-color:var(--bs-nav-tabs-link-active-border-color)}.nav-tabs .dropdown-menu{margin-top:calc(-1 * 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.show>.nav-link{font-weight:700;color:var(--bs-nav-underline-link-active-color);border-bottom-color:currentcolor}.nav-fill>.nav-link,.nav-fill .nav-item{flex:1 1 auto;-webkit-flex:1 1 auto;text-align:center}.nav-justified>.nav-link,.nav-justified .nav-item{flex-basis:0;-webkit-flex-basis:0;flex-grow:1;-webkit-flex-grow:1;text-align:center}.nav-fill .nav-item .nav-link,.nav-justified .nav-item .nav-link{width:100%}.tab-content>.tab-pane{display:none}.tab-content>.active{display:block}.navbar{--bs-navbar-padding-x: 0;--bs-navbar-padding-y: .5rem;--bs-navbar-color: rgba(var(--bs-emphasis-color-rgb), 0.65);--bs-navbar-hover-color: rgba(var(--bs-emphasis-color-rgb), 0.8);--bs-navbar-disabled-color: rgba(var(--bs-emphasis-color-rgb), 0.3);--bs-navbar-active-color: rgba(var(--bs-emphasis-color-rgb), 1);--bs-navbar-brand-padding-y: .3125rem;--bs-navbar-brand-margin-end: 1rem;--bs-navbar-brand-font-size: 1.25rem;--bs-navbar-brand-color: rgba(var(--bs-emphasis-color-rgb), 1);--bs-navbar-brand-hover-color: rgba(var(--bs-emphasis-color-rgb), 1);--bs-navbar-nav-link-padding-x: .5rem;--bs-navbar-toggler-padding-y: .25rem;--bs-navbar-toggler-padding-x: .75rem;--bs-navbar-toggler-font-size: 1.25rem;--bs-navbar-toggler-icon-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 30 30'%3e%3cpath stroke='rgba%2833,37,41,0.75%29' stroke-linecap='round' stroke-miterlimit='10' stroke-width='2' d='M4 7h22M4 15h22M4 23h22'/%3e%3c/svg%3e");--bs-navbar-toggler-border-color: rgba(var(--bs-emphasis-color-rgb), 0.15);--bs-navbar-toggler-border-radius: var(--bs-border-radius);--bs-navbar-toggler-focus-width: .25rem;--bs-navbar-toggler-transition: box-shadow 0.15s ease-in-out;position:relative;display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;align-items:center;-webkit-align-items:center;justify-content:space-between;-webkit-justify-content:space-between;padding:var(--bs-navbar-padding-y) 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.navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand-md .navbar-nav .dropdown-menu{position:absolute}.navbar-expand-md .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand-md .navbar-nav-scroll{overflow:visible}.navbar-expand-md .navbar-collapse{display:flex !important;display:-webkit-flex !important;flex-basis:auto;-webkit-flex-basis:auto}.navbar-expand-md .navbar-toggler{display:none}.navbar-expand-md .offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-md .offcanvas .offcanvas-header{display:none}.navbar-expand-md .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}}@media (min-width: 992px){.navbar-expand-lg{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand-lg .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand-lg .navbar-nav .dropdown-menu{position:absolute}.navbar-expand-lg .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand-lg .navbar-nav-scroll{overflow:visible}.navbar-expand-lg .navbar-collapse{display:flex !important;display:-webkit-flex !important;flex-basis:auto;-webkit-flex-basis:auto}.navbar-expand-lg .navbar-toggler{display:none}.navbar-expand-lg .offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-lg .offcanvas .offcanvas-header{display:none}.navbar-expand-lg .offcanvas 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.offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:transparent !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-xxl .offcanvas .offcanvas-header{display:none}.navbar-expand-xxl .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}}.navbar-expand{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand .navbar-nav .dropdown-menu{position:absolute}.navbar-expand .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand .navbar-nav-scroll{overflow:visible}.navbar-expand .navbar-collapse{display:flex !important;display:-webkit-flex 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wrap;-webkit-flex-flow:row wrap}.card-group>.card{flex:1 0 0%;-webkit-flex:1 0 0%;margin-bottom:0}.card-group>.card+.card{margin-left:0;border-left:0}.card-group>.card:not(:last-child){border-top-right-radius:0;border-bottom-right-radius:0}.card-group>.card:not(:last-child) .card-img-top,.card-group>.card:not(:last-child) .card-header{border-top-right-radius:0}.card-group>.card:not(:last-child) .card-img-bottom,.card-group>.card:not(:last-child) .card-footer{border-bottom-right-radius:0}.card-group>.card:not(:first-child){border-top-left-radius:0;border-bottom-left-radius:0}.card-group>.card:not(:first-child) .card-img-top,.card-group>.card:not(:first-child) .card-header{border-top-left-radius:0}.card-group>.card:not(:first-child) .card-img-bottom,.card-group>.card:not(:first-child) .card-footer{border-bottom-left-radius:0}}.accordion{--bs-accordion-color: var(--bs-body-color);--bs-accordion-bg: var(--bs-body-bg);--bs-accordion-transition: color 0.15s ease-in-out,background-color 0.15s ease-in-out,border-color 0.15s ease-in-out,box-shadow 0.15s ease-in-out,border-radius 0.15s ease;--bs-accordion-border-color: var(--bs-border-color);--bs-accordion-border-width: var(--bs-border-width);--bs-accordion-border-radius: var(--bs-border-radius);--bs-accordion-inner-border-radius: calc(var(--bs-border-radius) - (var(--bs-border-width)));--bs-accordion-btn-padding-x: 1.25rem;--bs-accordion-btn-padding-y: 1rem;--bs-accordion-btn-color: var(--bs-body-color);--bs-accordion-btn-bg: var(--bs-accordion-bg);--bs-accordion-btn-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23212529'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-icon-width: 1.25rem;--bs-accordion-btn-icon-transform: rotate(-180deg);--bs-accordion-btn-icon-transition: transform 0.2s ease-in-out;--bs-accordion-btn-active-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23052c65'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-focus-border-color: #86b7fe;--bs-accordion-btn-focus-box-shadow: 0 0 0 .25rem rgba(13,110,253,0.25);--bs-accordion-body-padding-x: 1.25rem;--bs-accordion-body-padding-y: 1rem;--bs-accordion-active-color: var(--bs-primary-text-emphasis);--bs-accordion-active-bg: var(--bs-primary-bg-subtle)}.accordion-button{position:relative;display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;width:100%;padding:var(--bs-accordion-btn-padding-y) var(--bs-accordion-btn-padding-x);font-size:1rem;color:var(--bs-accordion-btn-color);text-align:left;background-color:var(--bs-accordion-btn-bg);border:0;border-radius:0;overflow-anchor:none;transition:var(--bs-accordion-transition)}@media 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reduce){.accordion-button::after{transition:none}}.accordion-button:hover{z-index:2}.accordion-button:focus{z-index:3;border-color:var(--bs-accordion-btn-focus-border-color);outline:0;box-shadow:var(--bs-accordion-btn-focus-box-shadow)}.accordion-header{margin-bottom:0}.accordion-item{color:var(--bs-accordion-color);background-color:var(--bs-accordion-bg);border:var(--bs-accordion-border-width) solid var(--bs-accordion-border-color)}.accordion-item:first-of-type{border-top-left-radius:var(--bs-accordion-border-radius);border-top-right-radius:var(--bs-accordion-border-radius)}.accordion-item:first-of-type .accordion-button{border-top-left-radius:var(--bs-accordion-inner-border-radius);border-top-right-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:not(:first-of-type){border-top:0}.accordion-item:last-of-type{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-item:last-of-type .accordion-button.collapsed{border-bottom-right-radius:var(--bs-accordion-inner-border-radius);border-bottom-left-radius:var(--bs-accordion-inner-border-radius)}.accordion-item:last-of-type .accordion-collapse{border-bottom-right-radius:var(--bs-accordion-border-radius);border-bottom-left-radius:var(--bs-accordion-border-radius)}.accordion-body{padding:var(--bs-accordion-body-padding-y) var(--bs-accordion-body-padding-x)}.accordion-flush .accordion-collapse{border-width:0}.accordion-flush .accordion-item{border-right:0;border-left:0;border-radius:0}.accordion-flush .accordion-item:first-child{border-top:0}.accordion-flush .accordion-item:last-child{border-bottom:0}.accordion-flush .accordion-item .accordion-button,.accordion-flush .accordion-item .accordion-button.collapsed{border-radius:0}[data-bs-theme="dark"] .accordion-button::after{--bs-accordion-btn-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%236ea8fe'%3e%3cpath 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var(--bs-breadcrumb-padding-x);margin-bottom:var(--bs-breadcrumb-margin-bottom);font-size:var(--bs-breadcrumb-font-size);list-style:none;background-color:var(--bs-breadcrumb-bg);border-radius:var(--bs-breadcrumb-border-radius)}.breadcrumb-item+.breadcrumb-item{padding-left:var(--bs-breadcrumb-item-padding-x)}.breadcrumb-item+.breadcrumb-item::before{float:left;padding-right:var(--bs-breadcrumb-item-padding-x);color:var(--bs-breadcrumb-divider-color);content:var(--bs-breadcrumb-divider, "/") /* rtl: var(--bs-breadcrumb-divider, "/") */}.breadcrumb-item.active{color:var(--bs-breadcrumb-item-active-color)}.pagination{--bs-pagination-padding-x: .75rem;--bs-pagination-padding-y: .375rem;--bs-pagination-font-size:1rem;--bs-pagination-color: var(--bs-link-color);--bs-pagination-bg: var(--bs-body-bg);--bs-pagination-border-width: var(--bs-border-width);--bs-pagination-border-color: var(--bs-border-color);--bs-pagination-border-radius: var(--bs-border-radius);--bs-pagination-hover-color: 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var(--bs-pagination-padding-x);font-size:var(--bs-pagination-font-size);color:var(--bs-pagination-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-pagination-bg);border:var(--bs-pagination-border-width) solid var(--bs-pagination-border-color);transition:color 0.15s ease-in-out,background-color 0.15s ease-in-out,border-color 0.15s ease-in-out,box-shadow 0.15s ease-in-out}@media (prefers-reduced-motion: reduce){.page-link{transition:none}}.page-link:hover{z-index:2;color:var(--bs-pagination-hover-color);background-color:var(--bs-pagination-hover-bg);border-color:var(--bs-pagination-hover-border-color)}.page-link:focus{z-index:3;color:var(--bs-pagination-focus-color);background-color:var(--bs-pagination-focus-bg);outline:0;box-shadow:var(--bs-pagination-focus-box-shadow)}.page-link.active,.active>.page-link{z-index:3;color:var(--bs-pagination-active-color);background-color:var(--bs-pagination-active-bg);border-color:var(--bs-pagination-active-border-color)}.page-link.disabled,.disabled>.page-link{color:var(--bs-pagination-disabled-color);pointer-events:none;background-color:var(--bs-pagination-disabled-bg);border-color:var(--bs-pagination-disabled-border-color)}.page-item:not(:first-child) .page-link{margin-left:calc(var(--bs-border-width) * -1)}.page-item:first-child .page-link{border-top-left-radius:var(--bs-pagination-border-radius);border-bottom-left-radius:var(--bs-pagination-border-radius)}.page-item:last-child .page-link{border-top-right-radius:var(--bs-pagination-border-radius);border-bottom-right-radius:var(--bs-pagination-border-radius)}.pagination-lg{--bs-pagination-padding-x: 1.5rem;--bs-pagination-padding-y: .75rem;--bs-pagination-font-size:1.25rem;--bs-pagination-border-radius: var(--bs-border-radius-lg)}.pagination-sm{--bs-pagination-padding-x: .5rem;--bs-pagination-padding-y: .25rem;--bs-pagination-font-size:.875rem;--bs-pagination-border-radius: var(--bs-border-radius-sm)}.badge{--bs-badge-padding-x: .65em;--bs-badge-padding-y: .35em;--bs-badge-font-size:.75em;--bs-badge-font-weight: 700;--bs-badge-color: #fff;--bs-badge-border-radius: var(--bs-border-radius);display:inline-block;padding:var(--bs-badge-padding-y) var(--bs-badge-padding-x);font-size:var(--bs-badge-font-size);font-weight:var(--bs-badge-font-weight);line-height:1;color:var(--bs-badge-color);text-align:center;white-space:nowrap;vertical-align:baseline;border-radius:var(--bs-badge-border-radius)}.badge:empty{display:none}.btn .badge{position:relative;top:-1px}.alert{--bs-alert-bg: transparent;--bs-alert-padding-x: 1rem;--bs-alert-padding-y: 1rem;--bs-alert-margin-bottom: 1rem;--bs-alert-color: inherit;--bs-alert-border-color: transparent;--bs-alert-border: var(--bs-border-width) solid var(--bs-alert-border-color);--bs-alert-border-radius: var(--bs-border-radius);--bs-alert-link-color: inherit;position:relative;padding:var(--bs-alert-padding-y) var(--bs-alert-padding-x);margin-bottom:var(--bs-alert-margin-bottom);color:var(--bs-alert-color);background-color:var(--bs-alert-bg);border:var(--bs-alert-border);border-radius:var(--bs-alert-border-radius)}.alert-heading{color:inherit}.alert-link{font-weight:700;color:var(--bs-alert-link-color)}.alert-dismissible{padding-right:3rem}.alert-dismissible .btn-close{position:absolute;top:0;right:0;z-index:2;padding:1.25rem 1rem}.alert-default{--bs-alert-color: var(--bs-default-text-emphasis);--bs-alert-bg: var(--bs-default-bg-subtle);--bs-alert-border-color: var(--bs-default-border-subtle);--bs-alert-link-color: var(--bs-default-text-emphasis)}.alert-primary{--bs-alert-color: var(--bs-primary-text-emphasis);--bs-alert-bg: var(--bs-primary-bg-subtle);--bs-alert-border-color: var(--bs-primary-border-subtle);--bs-alert-link-color: var(--bs-primary-text-emphasis)}.alert-secondary{--bs-alert-color: var(--bs-secondary-text-emphasis);--bs-alert-bg: var(--bs-secondary-bg-subtle);--bs-alert-border-color: var(--bs-secondary-border-subtle);--bs-alert-link-color: var(--bs-secondary-text-emphasis)}.alert-success{--bs-alert-color: var(--bs-success-text-emphasis);--bs-alert-bg: var(--bs-success-bg-subtle);--bs-alert-border-color: var(--bs-success-border-subtle);--bs-alert-link-color: var(--bs-success-text-emphasis)}.alert-info{--bs-alert-color: var(--bs-info-text-emphasis);--bs-alert-bg: var(--bs-info-bg-subtle);--bs-alert-border-color: var(--bs-info-border-subtle);--bs-alert-link-color: var(--bs-info-text-emphasis)}.alert-warning{--bs-alert-color: var(--bs-warning-text-emphasis);--bs-alert-bg: var(--bs-warning-bg-subtle);--bs-alert-border-color: var(--bs-warning-border-subtle);--bs-alert-link-color: var(--bs-warning-text-emphasis)}.alert-danger{--bs-alert-color: var(--bs-danger-text-emphasis);--bs-alert-bg: var(--bs-danger-bg-subtle);--bs-alert-border-color: var(--bs-danger-border-subtle);--bs-alert-link-color: var(--bs-danger-text-emphasis)}.alert-light{--bs-alert-color: var(--bs-light-text-emphasis);--bs-alert-bg: var(--bs-light-bg-subtle);--bs-alert-border-color: var(--bs-light-border-subtle);--bs-alert-link-color: var(--bs-light-text-emphasis)}.alert-dark{--bs-alert-color: var(--bs-dark-text-emphasis);--bs-alert-bg: var(--bs-dark-bg-subtle);--bs-alert-border-color: var(--bs-dark-border-subtle);--bs-alert-link-color: var(--bs-dark-text-emphasis)}@keyframes progress-bar-stripes{0%{background-position-x:1rem}}.progress,.progress-stacked{--bs-progress-height: 1rem;--bs-progress-font-size:.75rem;--bs-progress-bg: var(--bs-secondary-bg);--bs-progress-border-radius: var(--bs-border-radius);--bs-progress-box-shadow: var(--bs-box-shadow-inset);--bs-progress-bar-color: #fff;--bs-progress-bar-bg: #0d6efd;--bs-progress-bar-transition: width 0.6s ease;display:flex;display:-webkit-flex;height:var(--bs-progress-height);overflow:hidden;font-size:var(--bs-progress-font-size);background-color:var(--bs-progress-bg);border-radius:var(--bs-progress-border-radius)}.progress-bar{display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;justify-content:center;-webkit-justify-content:center;overflow:hidden;color:var(--bs-progress-bar-color);text-align:center;white-space:nowrap;background-color:var(--bs-progress-bar-bg);transition:var(--bs-progress-bar-transition)}@media (prefers-reduced-motion: reduce){.progress-bar{transition:none}}.progress-bar-striped{background-image:linear-gradient(45deg, rgba(255,255,255,0.15) 25%, transparent 25%, transparent 50%, rgba(255,255,255,0.15) 50%, rgba(255,255,255,0.15) 75%, transparent 75%, transparent);background-size:var(--bs-progress-height) var(--bs-progress-height)}.progress-stacked>.progress{overflow:visible}.progress-stacked>.progress>.progress-bar{width:100%}.progress-bar-animated{animation:1s linear infinite progress-bar-stripes}@media (prefers-reduced-motion: reduce){.progress-bar-animated{animation:none}}.list-group{--bs-list-group-color: var(--bs-body-color);--bs-list-group-bg: var(--bs-body-bg);--bs-list-group-border-color: var(--bs-border-color);--bs-list-group-border-width: var(--bs-border-width);--bs-list-group-border-radius: var(--bs-border-radius);--bs-list-group-item-padding-x: 1rem;--bs-list-group-item-padding-y: .5rem;--bs-list-group-action-color: var(--bs-secondary-color);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-tertiary-bg);--bs-list-group-action-active-color: var(--bs-body-color);--bs-list-group-action-active-bg: var(--bs-secondary-bg);--bs-list-group-disabled-color: var(--bs-secondary-color);--bs-list-group-disabled-bg: 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";counter-increment:section}.list-group-item-action{width:100%;color:var(--bs-list-group-action-color);text-align:inherit}.list-group-item-action:hover,.list-group-item-action:focus{z-index:1;color:var(--bs-list-group-action-hover-color);text-decoration:none;background-color:var(--bs-list-group-action-hover-bg)}.list-group-item-action:active{color:var(--bs-list-group-action-active-color);background-color:var(--bs-list-group-action-active-bg)}.list-group-item{position:relative;display:block;padding:var(--bs-list-group-item-padding-y) var(--bs-list-group-item-padding-x);color:var(--bs-list-group-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-list-group-bg);border:var(--bs-list-group-border-width) solid 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var(--bs-list-group-border-width));border-top-width:var(--bs-list-group-border-width)}.list-group-horizontal{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal>.list-group-item.active{margin-top:0}.list-group-horizontal>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}@media (min-width: 576px){.list-group-horizontal-sm{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-sm>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-sm>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-sm>.list-group-item.active{margin-top:0}.list-group-horizontal-sm>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-sm>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 768px){.list-group-horizontal-md{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-md>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-md>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-md>.list-group-item.active{margin-top:0}.list-group-horizontal-md>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-md>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 992px){.list-group-horizontal-lg{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-lg>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-lg>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-lg>.list-group-item.active{margin-top:0}.list-group-horizontal-lg>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-lg>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 1200px){.list-group-horizontal-xl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xl>.list-group-item:first-child:not(:last-child){border-bottom-left-radius:var(--bs-list-group-border-radius);border-top-right-radius:0}.list-group-horizontal-xl>.list-group-item:last-child:not(:first-child){border-top-right-radius:var(--bs-list-group-border-radius);border-bottom-left-radius:0}.list-group-horizontal-xl>.list-group-item.active{margin-top:0}.list-group-horizontal-xl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xl>.list-group-item+.list-group-item.active{margin-left:calc(-1 * var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media (min-width: 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var(--bs-list-group-border-width)}.list-group-flush>.list-group-item:last-child{border-bottom-width:0}.list-group-item-default{--bs-list-group-color: var(--bs-default-text-emphasis);--bs-list-group-bg: var(--bs-default-bg-subtle);--bs-list-group-border-color: var(--bs-default-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-default-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-default-border-subtle);--bs-list-group-active-color: var(--bs-default-bg-subtle);--bs-list-group-active-bg: var(--bs-default-text-emphasis);--bs-list-group-active-border-color: var(--bs-default-text-emphasis)}.list-group-item-primary{--bs-list-group-color: var(--bs-primary-text-emphasis);--bs-list-group-bg: var(--bs-primary-bg-subtle);--bs-list-group-border-color: var(--bs-primary-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-primary-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-primary-border-subtle);--bs-list-group-active-color: var(--bs-primary-bg-subtle);--bs-list-group-active-bg: var(--bs-primary-text-emphasis);--bs-list-group-active-border-color: var(--bs-primary-text-emphasis)}.list-group-item-secondary{--bs-list-group-color: var(--bs-secondary-text-emphasis);--bs-list-group-bg: var(--bs-secondary-bg-subtle);--bs-list-group-border-color: var(--bs-secondary-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-secondary-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-secondary-border-subtle);--bs-list-group-active-color: var(--bs-secondary-bg-subtle);--bs-list-group-active-bg: var(--bs-secondary-text-emphasis);--bs-list-group-active-border-color: var(--bs-secondary-text-emphasis)}.list-group-item-success{--bs-list-group-color: var(--bs-success-text-emphasis);--bs-list-group-bg: var(--bs-success-bg-subtle);--bs-list-group-border-color: var(--bs-success-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-success-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-success-border-subtle);--bs-list-group-active-color: var(--bs-success-bg-subtle);--bs-list-group-active-bg: var(--bs-success-text-emphasis);--bs-list-group-active-border-color: var(--bs-success-text-emphasis)}.list-group-item-info{--bs-list-group-color: var(--bs-info-text-emphasis);--bs-list-group-bg: var(--bs-info-bg-subtle);--bs-list-group-border-color: var(--bs-info-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-info-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-info-border-subtle);--bs-list-group-active-color: var(--bs-info-bg-subtle);--bs-list-group-active-bg: var(--bs-info-text-emphasis);--bs-list-group-active-border-color: var(--bs-info-text-emphasis)}.list-group-item-warning{--bs-list-group-color: var(--bs-warning-text-emphasis);--bs-list-group-bg: var(--bs-warning-bg-subtle);--bs-list-group-border-color: var(--bs-warning-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-warning-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-warning-border-subtle);--bs-list-group-active-color: var(--bs-warning-bg-subtle);--bs-list-group-active-bg: var(--bs-warning-text-emphasis);--bs-list-group-active-border-color: var(--bs-warning-text-emphasis)}.list-group-item-danger{--bs-list-group-color: var(--bs-danger-text-emphasis);--bs-list-group-bg: var(--bs-danger-bg-subtle);--bs-list-group-border-color: var(--bs-danger-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-danger-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-danger-border-subtle);--bs-list-group-active-color: var(--bs-danger-bg-subtle);--bs-list-group-active-bg: var(--bs-danger-text-emphasis);--bs-list-group-active-border-color: var(--bs-danger-text-emphasis)}.list-group-item-light{--bs-list-group-color: var(--bs-light-text-emphasis);--bs-list-group-bg: var(--bs-light-bg-subtle);--bs-list-group-border-color: var(--bs-light-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-light-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-light-border-subtle);--bs-list-group-active-color: var(--bs-light-bg-subtle);--bs-list-group-active-bg: var(--bs-light-text-emphasis);--bs-list-group-active-border-color: var(--bs-light-text-emphasis)}.list-group-item-dark{--bs-list-group-color: var(--bs-dark-text-emphasis);--bs-list-group-bg: var(--bs-dark-bg-subtle);--bs-list-group-border-color: var(--bs-dark-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-dark-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-dark-border-subtle);--bs-list-group-active-color: var(--bs-dark-bg-subtle);--bs-list-group-active-bg: var(--bs-dark-text-emphasis);--bs-list-group-active-border-color: var(--bs-dark-text-emphasis)}.btn-close{--bs-btn-close-color: #000;--bs-btn-close-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' 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var(--bs-border-width);position:fixed;top:0;left:0;z-index:var(--bs-modal-zindex);display:none;width:100%;height:100%;overflow-x:hidden;overflow-y:auto;outline:0}.modal-dialog{position:relative;width:auto;margin:var(--bs-modal-margin);pointer-events:none}.modal.fade .modal-dialog{transition:transform 0.3s ease-out;transform:translate(0, -50px)}@media (prefers-reduced-motion: reduce){.modal.fade .modal-dialog{transition:none}}.modal.show .modal-dialog{transform:none}.modal.modal-static .modal-dialog{transform:scale(1.02)}.modal-dialog-scrollable{height:calc(100% - var(--bs-modal-margin) * 2)}.modal-dialog-scrollable .modal-content{max-height:100%;overflow:hidden}.modal-dialog-scrollable .modal-body{overflow-y:auto}.modal-dialog-centered{display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;min-height:calc(100% - var(--bs-modal-margin) * 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diff --git a/deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js b/deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js
new file mode 100644
index 0000000..c628326
--- /dev/null
+++ b/deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js
@@ -0,0 +1,5 @@
+/*!
+ * Bootstrap Table of Contents v1.0.1 (http://afeld.github.io/bootstrap-toc/)
+ * Copyright 2015 Aidan Feldman
+ * Licensed under MIT (https://github.com/afeld/bootstrap-toc/blob/gh-pages/LICENSE.md) */
+!function(a){"use strict";window.Toc={helpers:{findOrFilter:function(e,t){var n=e.find(t);return e.filter(t).add(n).filter(":not([data-toc-skip])")},generateUniqueIdBase:function(e){return a(e).text().trim().replace(/\'/gi,"").replace(/[& +$,:;=?@"#{}|^~[`%!'<>\]\.\/\(\)\*\\\n\t\b\v]/g,"-").replace(/-{2,}/g,"-").substring(0,64).replace(/^-+|-+$/gm,"").toLowerCase()||e.tagName.toLowerCase()},generateUniqueId:function(e){for(var t=this.generateUniqueIdBase(e),n=0;;n++){var r=t;if(0<n&&(r+="-"+n),!document.getElementById(r))return r}},generateAnchor:function(e){if(e.id)return e.id;var t=this.generateUniqueId(e);return e.id=t},createNavList:function(){return a('<ul class="nav navbar-nav"></ul>')},createChildNavList:function(e){var t=this.createNavList();return e.append(t),t},generateNavEl:function(e,t){var n=a('<a class="nav-link"></a>');n.attr("href","#"+e),n.text(t);var r=a("<li></li>");return r.append(n),r},generateNavItem:function(e){var t=this.generateAnchor(e),n=a(e),r=n.data("toc-text")||n.text();return this.generateNavEl(t,r)},getTopLevel:function(e){for(var t=1;t<=6;t++){if(1<this.findOrFilter(e,"h"+t).length)return t}return 1},getHeadings:function(e,t){var n="h"+t,r="h"+(t+1);return this.findOrFilter(e,n+","+r)},getNavLevel:function(e){return parseInt(e.tagName.charAt(1),10)},populateNav:function(r,a,e){var i,s=r,c=this;e.each(function(e,t){var n=c.generateNavItem(t);c.getNavLevel(t)===a?s=r:i&&s===r&&(s=c.createChildNavList(i)),s.append(n),i=n})},parseOps:function(e){var t;return(t=e.jquery?{$nav:e}:e).$scope=t.$scope||a(document.body),t}},init:function(e){(e=this.helpers.parseOps(e)).$nav.attr("data-toggle","toc");var t=this.helpers.createChildNavList(e.$nav),n=this.helpers.getTopLevel(e.$scope),r=this.helpers.getHeadings(e.$scope,n);this.helpers.populateNav(t,n,r)}},a(function(){a('nav[data-toggle="toc"]').each(function(e,t){var n=a(t);Toc.init(n)})})}(jQuery);
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diff --git a/deps/clipboard.js-2.0.11/clipboard.min.js b/deps/clipboard.js-2.0.11/clipboard.min.js
new file mode 100644
index 0000000..1103f81
--- /dev/null
+++ b/deps/clipboard.js-2.0.11/clipboard.min.js
@@ -0,0 +1,7 @@
+/*!
+ * clipboard.js v2.0.11
+ * https://clipboardjs.com/
+ *
+ * Licensed MIT © Zeno Rocha
+ */
+!function(t,e){"object"==typeof exports&&"object"==typeof module?module.exports=e():"function"==typeof define&&define.amd?define([],e):"object"==typeof exports?exports.ClipboardJS=e():t.ClipboardJS=e()}(this,function(){return n={686:function(t,e,n){"use strict";n.d(e,{default:function(){return b}});var e=n(279),i=n.n(e),e=n(370),u=n.n(e),e=n(817),r=n.n(e);function c(t){try{return document.execCommand(t)}catch(t){return}}var a=function(t){t=r()(t);return c("cut"),t};function o(t,e){var n,o,t=(n=t,o="rtl"===document.documentElement.getAttribute("dir"),(t=document.createElement("textarea")).style.fontSize="12pt",t.style.border="0",t.style.padding="0",t.style.margin="0",t.style.position="absolute",t.style[o?"right":"left"]="-9999px",o=window.pageYOffset||document.documentElement.scrollTop,t.style.top="".concat(o,"px"),t.setAttribute("readonly",""),t.value=n,t);return e.container.appendChild(t),e=r()(t),c("copy"),t.remove(),e}var f=function(t){var e=1<arguments.length&&void 0!==arguments[1]?arguments[1]:{container:document.body},n="";return"string"==typeof t?n=o(t,e):t instanceof HTMLInputElement&&!["text","search","url","tel","password"].includes(null==t?void 0:t.type)?n=o(t.value,e):(n=r()(t),c("copy")),n};function l(t){return(l="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(t){return typeof t}:function(t){return t&&"function"==typeof Symbol&&t.constructor===Symbol&&t!==Symbol.prototype?"symbol":typeof t})(t)}var s=function(){var t=0<arguments.length&&void 0!==arguments[0]?arguments[0]:{},e=t.action,n=void 0===e?"copy":e,o=t.container,e=t.target,t=t.text;if("copy"!==n&&"cut"!==n)throw new Error('Invalid "action" value, use either "copy" or "cut"');if(void 0!==e){if(!e||"object"!==l(e)||1!==e.nodeType)throw new Error('Invalid "target" value, use a valid Element');if("copy"===n&&e.hasAttribute("disabled"))throw new Error('Invalid "target" attribute. 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diff --git a/deps/data-deps.txt b/deps/data-deps.txt
index 693b82d..8aa49e2 100644
--- a/deps/data-deps.txt
+++ b/deps/data-deps.txt
@@ -2,3 +2,12 @@
 <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no" />
 <link href="deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet" />
 <script src="deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script>
+<link href="deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet" />
+<link href="deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet" />
+<script src="deps/headroom-0.11.0/headroom.min.js"></script>
+<script src="deps/headroom-0.11.0/jQuery.headroom.min.js"></script>
+<script src="deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script>
+<script src="deps/clipboard.js-2.0.11/clipboard.min.js"></script>
+<script src="deps/search-1.0.0/autocomplete.jquery.min.js"></script>
+<script src="deps/search-1.0.0/fuse.min.js"></script>
+<script src="deps/search-1.0.0/mark.min.js"></script>
diff --git a/deps/font-awesome-6.4.2/css/all.css b/deps/font-awesome-6.4.2/css/all.css
new file mode 100644
index 0000000..bdb6e3a
--- /dev/null
+++ b/deps/font-awesome-6.4.2/css/all.css
@@ -0,0 +1,7968 @@
+/*!
+ * Font Awesome Free 6.4.2 by @fontawesome - https://fontawesome.com
+ * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)
+ * Copyright 2023 Fonticons, Inc.
+ */
+.fa {
+  font-family: var(--fa-style-family, "Font Awesome 6 Free");
+  font-weight: var(--fa-style, 900); }
+
+.fa,
+.fa-classic,
+.fa-sharp,
+.fas,
+.fa-solid,
+.far,
+.fa-regular,
+.fab,
+.fa-brands {
+  -moz-osx-font-smoothing: grayscale;
+  -webkit-font-smoothing: antialiased;
+  display: var(--fa-display, inline-block);
+  font-style: normal;
+  font-variant: normal;
+  line-height: 1;
+  text-rendering: auto; }
+
+.fas,
+.fa-classic,
+.fa-solid,
+.far,
+.fa-regular {
+  font-family: 'Font Awesome 6 Free'; }
+
+.fab,
+.fa-brands {
+  font-family: 'Font Awesome 6 Brands'; }
+
+.fa-1x {
+  font-size: 1em; }
+
+.fa-2x {
+  font-size: 2em; }
+
+.fa-3x {
+  font-size: 3em; }
+
+.fa-4x {
+  font-size: 4em; }
+
+.fa-5x {
+  font-size: 5em; }
+
+.fa-6x {
+  font-size: 6em; }
+
+.fa-7x {
+  font-size: 7em; }
+
+.fa-8x {
+  font-size: 8em; }
+
+.fa-9x {
+  font-size: 9em; }
+
+.fa-10x {
+  font-size: 10em; }
+
+.fa-2xs {
+  font-size: 0.625em;
+  line-height: 0.1em;
+  vertical-align: 0.225em; }
+
+.fa-xs {
+  font-size: 0.75em;
+  line-height: 0.08333em;
+  vertical-align: 0.125em; }
+
+.fa-sm {
+  font-size: 0.875em;
+  line-height: 0.07143em;
+  vertical-align: 0.05357em; }
+
+.fa-lg {
+  font-size: 1.25em;
+  line-height: 0.05em;
+  vertical-align: -0.075em; }
+
+.fa-xl {
+  font-size: 1.5em;
+  line-height: 0.04167em;
+  vertical-align: -0.125em; }
+
+.fa-2xl {
+  font-size: 2em;
+  line-height: 0.03125em;
+  vertical-align: -0.1875em; }
+
+.fa-fw {
+  text-align: center;
+  width: 1.25em; }
+
+.fa-ul {
+  list-style-type: none;
+  margin-left: var(--fa-li-margin, 2.5em);
+  padding-left: 0; }
+  .fa-ul > li {
+    position: relative; }
+
+.fa-li {
+  left: calc(var(--fa-li-width, 2em) * -1);
+  position: absolute;
+  text-align: center;
+  width: var(--fa-li-width, 2em);
+  line-height: inherit; }
+
+.fa-border {
+  border-color: var(--fa-border-color, #eee);
+  border-radius: var(--fa-border-radius, 0.1em);
+  border-style: var(--fa-border-style, solid);
+  border-width: var(--fa-border-width, 0.08em);
+  padding: var(--fa-border-padding, 0.2em 0.25em 0.15em); }
+
+.fa-pull-left {
+  float: left;
+  margin-right: var(--fa-pull-margin, 0.3em); }
+
+.fa-pull-right {
+  float: right;
+  margin-left: var(--fa-pull-margin, 0.3em); }
+
+.fa-beat {
+  -webkit-animation-name: fa-beat;
+          animation-name: fa-beat;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, ease-in-out);
+          animation-timing-function: var(--fa-animation-timing, ease-in-out); }
+
+.fa-bounce {
+  -webkit-animation-name: fa-bounce;
+          animation-name: fa-bounce;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.28, 0.84, 0.42, 1));
+          animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.28, 0.84, 0.42, 1)); }
+
+.fa-fade {
+  -webkit-animation-name: fa-fade;
+          animation-name: fa-fade;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1));
+          animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); }
+
+.fa-beat-fade {
+  -webkit-animation-name: fa-beat-fade;
+          animation-name: fa-beat-fade;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1));
+          animation-timing-function: var(--fa-animation-timing, cubic-bezier(0.4, 0, 0.6, 1)); }
+
+.fa-flip {
+  -webkit-animation-name: fa-flip;
+          animation-name: fa-flip;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, ease-in-out);
+          animation-timing-function: var(--fa-animation-timing, ease-in-out); }
+
+.fa-shake {
+  -webkit-animation-name: fa-shake;
+          animation-name: fa-shake;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, linear);
+          animation-timing-function: var(--fa-animation-timing, linear); }
+
+.fa-spin {
+  -webkit-animation-name: fa-spin;
+          animation-name: fa-spin;
+  -webkit-animation-delay: var(--fa-animation-delay, 0s);
+          animation-delay: var(--fa-animation-delay, 0s);
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 2s);
+          animation-duration: var(--fa-animation-duration, 2s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, linear);
+          animation-timing-function: var(--fa-animation-timing, linear); }
+
+.fa-spin-reverse {
+  --fa-animation-direction: reverse; }
+
+.fa-pulse,
+.fa-spin-pulse {
+  -webkit-animation-name: fa-spin;
+          animation-name: fa-spin;
+  -webkit-animation-direction: var(--fa-animation-direction, normal);
+          animation-direction: var(--fa-animation-direction, normal);
+  -webkit-animation-duration: var(--fa-animation-duration, 1s);
+          animation-duration: var(--fa-animation-duration, 1s);
+  -webkit-animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+          animation-iteration-count: var(--fa-animation-iteration-count, infinite);
+  -webkit-animation-timing-function: var(--fa-animation-timing, steps(8));
+          animation-timing-function: var(--fa-animation-timing, steps(8)); }
+
+@media (prefers-reduced-motion: reduce) {
+  .fa-beat,
+  .fa-bounce,
+  .fa-fade,
+  .fa-beat-fade,
+  .fa-flip,
+  .fa-pulse,
+  .fa-shake,
+  .fa-spin,
+  .fa-spin-pulse {
+    -webkit-animation-delay: -1ms;
+            animation-delay: -1ms;
+    -webkit-animation-duration: 1ms;
+            animation-duration: 1ms;
+    -webkit-animation-iteration-count: 1;
+            animation-iteration-count: 1;
+    -webkit-transition-delay: 0s;
+            transition-delay: 0s;
+    -webkit-transition-duration: 0s;
+            transition-duration: 0s; } }
+
+@-webkit-keyframes fa-beat {
+  0%, 90% {
+    -webkit-transform: scale(1);
+            transform: scale(1); }
+  45% {
+    -webkit-transform: scale(var(--fa-beat-scale, 1.25));
+            transform: scale(var(--fa-beat-scale, 1.25)); } }
+
+@keyframes fa-beat {
+  0%, 90% {
+    -webkit-transform: scale(1);
+            transform: scale(1); }
+  45% {
+    -webkit-transform: scale(var(--fa-beat-scale, 1.25));
+            transform: scale(var(--fa-beat-scale, 1.25)); } }
+
+@-webkit-keyframes fa-bounce {
+  0% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); }
+  10% {
+    -webkit-transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0);
+            transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); }
+  30% {
+    -webkit-transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em));
+            transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); }
+  50% {
+    -webkit-transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0);
+            transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); }
+  57% {
+    -webkit-transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em));
+            transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); }
+  64% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); }
+  100% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); } }
+
+@keyframes fa-bounce {
+  0% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); }
+  10% {
+    -webkit-transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0);
+            transform: scale(var(--fa-bounce-start-scale-x, 1.1), var(--fa-bounce-start-scale-y, 0.9)) translateY(0); }
+  30% {
+    -webkit-transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em));
+            transform: scale(var(--fa-bounce-jump-scale-x, 0.9), var(--fa-bounce-jump-scale-y, 1.1)) translateY(var(--fa-bounce-height, -0.5em)); }
+  50% {
+    -webkit-transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0);
+            transform: scale(var(--fa-bounce-land-scale-x, 1.05), var(--fa-bounce-land-scale-y, 0.95)) translateY(0); }
+  57% {
+    -webkit-transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em));
+            transform: scale(1, 1) translateY(var(--fa-bounce-rebound, -0.125em)); }
+  64% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); }
+  100% {
+    -webkit-transform: scale(1, 1) translateY(0);
+            transform: scale(1, 1) translateY(0); } }
+
+@-webkit-keyframes fa-fade {
+  50% {
+    opacity: var(--fa-fade-opacity, 0.4); } }
+
+@keyframes fa-fade {
+  50% {
+    opacity: var(--fa-fade-opacity, 0.4); } }
+
+@-webkit-keyframes fa-beat-fade {
+  0%, 100% {
+    opacity: var(--fa-beat-fade-opacity, 0.4);
+    -webkit-transform: scale(1);
+            transform: scale(1); }
+  50% {
+    opacity: 1;
+    -webkit-transform: scale(var(--fa-beat-fade-scale, 1.125));
+            transform: scale(var(--fa-beat-fade-scale, 1.125)); } }
+
+@keyframes fa-beat-fade {
+  0%, 100% {
+    opacity: var(--fa-beat-fade-opacity, 0.4);
+    -webkit-transform: scale(1);
+            transform: scale(1); }
+  50% {
+    opacity: 1;
+    -webkit-transform: scale(var(--fa-beat-fade-scale, 1.125));
+            transform: scale(var(--fa-beat-fade-scale, 1.125)); } }
+
+@-webkit-keyframes fa-flip {
+  50% {
+    -webkit-transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg));
+            transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); } }
+
+@keyframes fa-flip {
+  50% {
+    -webkit-transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg));
+            transform: rotate3d(var(--fa-flip-x, 0), var(--fa-flip-y, 1), var(--fa-flip-z, 0), var(--fa-flip-angle, -180deg)); } }
+
+@-webkit-keyframes fa-shake {
+  0% {
+    -webkit-transform: rotate(-15deg);
+            transform: rotate(-15deg); }
+  4% {
+    -webkit-transform: rotate(15deg);
+            transform: rotate(15deg); }
+  8%, 24% {
+    -webkit-transform: rotate(-18deg);
+            transform: rotate(-18deg); }
+  12%, 28% {
+    -webkit-transform: rotate(18deg);
+            transform: rotate(18deg); }
+  16% {
+    -webkit-transform: rotate(-22deg);
+            transform: rotate(-22deg); }
+  20% {
+    -webkit-transform: rotate(22deg);
+            transform: rotate(22deg); }
+  32% {
+    -webkit-transform: rotate(-12deg);
+            transform: rotate(-12deg); }
+  36% {
+    -webkit-transform: rotate(12deg);
+            transform: rotate(12deg); }
+  40%, 100% {
+    -webkit-transform: rotate(0deg);
+            transform: rotate(0deg); } }
+
+@keyframes fa-shake {
+  0% {
+    -webkit-transform: rotate(-15deg);
+            transform: rotate(-15deg); }
+  4% {
+    -webkit-transform: rotate(15deg);
+            transform: rotate(15deg); }
+  8%, 24% {
+    -webkit-transform: rotate(-18deg);
+            transform: rotate(-18deg); }
+  12%, 28% {
+    -webkit-transform: rotate(18deg);
+            transform: rotate(18deg); }
+  16% {
+    -webkit-transform: rotate(-22deg);
+            transform: rotate(-22deg); }
+  20% {
+    -webkit-transform: rotate(22deg);
+            transform: rotate(22deg); }
+  32% {
+    -webkit-transform: rotate(-12deg);
+            transform: rotate(-12deg); }
+  36% {
+    -webkit-transform: rotate(12deg);
+            transform: rotate(12deg); }
+  40%, 100% {
+    -webkit-transform: rotate(0deg);
+            transform: rotate(0deg); } }
+
+@-webkit-keyframes fa-spin {
+  0% {
+    -webkit-transform: rotate(0deg);
+            transform: rotate(0deg); }
+  100% {
+    -webkit-transform: rotate(360deg);
+            transform: rotate(360deg); } }
+
+@keyframes fa-spin {
+  0% {
+    -webkit-transform: rotate(0deg);
+            transform: rotate(0deg); }
+  100% {
+    -webkit-transform: rotate(360deg);
+            transform: rotate(360deg); } }
+
+.fa-rotate-90 {
+  -webkit-transform: rotate(90deg);
+          transform: rotate(90deg); }
+
+.fa-rotate-180 {
+  -webkit-transform: rotate(180deg);
+          transform: rotate(180deg); }
+
+.fa-rotate-270 {
+  -webkit-transform: rotate(270deg);
+          transform: rotate(270deg); }
+
+.fa-flip-horizontal {
+  -webkit-transform: scale(-1, 1);
+          transform: scale(-1, 1); }
+
+.fa-flip-vertical {
+  -webkit-transform: scale(1, -1);
+          transform: scale(1, -1); }
+
+.fa-flip-both,
+.fa-flip-horizontal.fa-flip-vertical {
+  -webkit-transform: scale(-1, -1);
+          transform: scale(-1, -1); }
+
+.fa-rotate-by {
+  -webkit-transform: rotate(var(--fa-rotate-angle, none));
+          transform: rotate(var(--fa-rotate-angle, none)); }
+
+.fa-stack {
+  display: inline-block;
+  height: 2em;
+  line-height: 2em;
+  position: relative;
+  vertical-align: middle;
+  width: 2.5em; }
+
+.fa-stack-1x,
+.fa-stack-2x {
+  left: 0;
+  position: absolute;
+  text-align: center;
+  width: 100%;
+  z-index: var(--fa-stack-z-index, auto); }
+
+.fa-stack-1x {
+  line-height: inherit; }
+
+.fa-stack-2x {
+  font-size: 2em; }
+
+.fa-inverse {
+  color: var(--fa-inverse, #fff); }
+
+/* Font Awesome uses the Unicode Private Use Area (PUA) to ensure screen
+readers do not read off random characters that represent icons */
+
+.fa-0::before {
+  content: "\30"; }
+
+.fa-1::before {
+  content: "\31"; }
+
+.fa-2::before {
+  content: "\32"; }
+
+.fa-3::before {
+  content: "\33"; }
+
+.fa-4::before {
+  content: "\34"; }
+
+.fa-5::before {
+  content: "\35"; }
+
+.fa-6::before {
+  content: "\36"; }
+
+.fa-7::before {
+  content: "\37"; }
+
+.fa-8::before {
+  content: "\38"; }
+
+.fa-9::before {
+  content: "\39"; }
+
+.fa-fill-drip::before {
+  content: "\f576"; }
+
+.fa-arrows-to-circle::before {
+  content: "\e4bd"; }
+
+.fa-circle-chevron-right::before {
+  content: "\f138"; }
+
+.fa-chevron-circle-right::before {
+  content: "\f138"; }
+
+.fa-at::before {
+  content: "\40"; }
+
+.fa-trash-can::before {
+  content: "\f2ed"; }
+
+.fa-trash-alt::before {
+  content: "\f2ed"; }
+
+.fa-text-height::before {
+  content: "\f034"; }
+
+.fa-user-xmark::before {
+  content: "\f235"; }
+
+.fa-user-times::before {
+  content: "\f235"; }
+
+.fa-stethoscope::before {
+  content: "\f0f1"; }
+
+.fa-message::before {
+  content: "\f27a"; }
+
+.fa-comment-alt::before {
+  content: "\f27a"; }
+
+.fa-info::before {
+  content: "\f129"; }
+
+.fa-down-left-and-up-right-to-center::before {
+  content: "\f422"; }
+
+.fa-compress-alt::before {
+  content: "\f422"; }
+
+.fa-explosion::before {
+  content: "\e4e9"; }
+
+.fa-file-lines::before {
+  content: "\f15c"; }
+
+.fa-file-alt::before {
+  content: "\f15c"; }
+
+.fa-file-text::before {
+  content: "\f15c"; }
+
+.fa-wave-square::before {
+  content: "\f83e"; }
+
+.fa-ring::before {
+  content: "\f70b"; }
+
+.fa-building-un::before {
+  content: "\e4d9"; }
+
+.fa-dice-three::before {
+  content: "\f527"; }
+
+.fa-calendar-days::before {
+  content: "\f073"; }
+
+.fa-calendar-alt::before {
+  content: "\f073"; }
+
+.fa-anchor-circle-check::before {
+  content: "\e4aa"; }
+
+.fa-building-circle-arrow-right::before {
+  content: "\e4d1"; }
+
+.fa-volleyball::before {
+  content: "\f45f"; }
+
+.fa-volleyball-ball::before {
+  content: "\f45f"; }
+
+.fa-arrows-up-to-line::before {
+  content: "\e4c2"; }
+
+.fa-sort-down::before {
+  content: "\f0dd"; }
+
+.fa-sort-desc::before {
+  content: "\f0dd"; }
+
+.fa-circle-minus::before {
+  content: "\f056"; }
+
+.fa-minus-circle::before {
+  content: "\f056"; }
+
+.fa-door-open::before {
+  content: "\f52b"; }
+
+.fa-right-from-bracket::before {
+  content: "\f2f5"; }
+
+.fa-sign-out-alt::before {
+  content: "\f2f5"; }
+
+.fa-atom::before {
+  content: "\f5d2"; }
+
+.fa-soap::before {
+  content: "\e06e"; }
+
+.fa-icons::before {
+  content: "\f86d"; }
+
+.fa-heart-music-camera-bolt::before {
+  content: "\f86d"; }
+
+.fa-microphone-lines-slash::before {
+  content: "\f539"; }
+
+.fa-microphone-alt-slash::before {
+  content: "\f539"; }
+
+.fa-bridge-circle-check::before {
+  content: "\e4c9"; }
+
+.fa-pump-medical::before {
+  content: "\e06a"; }
+
+.fa-fingerprint::before {
+  content: "\f577"; }
+
+.fa-hand-point-right::before {
+  content: "\f0a4"; }
+
+.fa-magnifying-glass-location::before {
+  content: "\f689"; }
+
+.fa-search-location::before {
+  content: "\f689"; }
+
+.fa-forward-step::before {
+  content: "\f051"; }
+
+.fa-step-forward::before {
+  content: "\f051"; }
+
+.fa-face-smile-beam::before {
+  content: "\f5b8"; }
+
+.fa-smile-beam::before {
+  content: "\f5b8"; }
+
+.fa-flag-checkered::before {
+  content: "\f11e"; }
+
+.fa-football::before {
+  content: "\f44e"; }
+
+.fa-football-ball::before {
+  content: "\f44e"; }
+
+.fa-school-circle-exclamation::before {
+  content: "\e56c"; }
+
+.fa-crop::before {
+  content: "\f125"; }
+
+.fa-angles-down::before {
+  content: "\f103"; }
+
+.fa-angle-double-down::before {
+  content: "\f103"; }
+
+.fa-users-rectangle::before {
+  content: "\e594"; }
+
+.fa-people-roof::before {
+  content: "\e537"; }
+
+.fa-people-line::before {
+  content: "\e534"; }
+
+.fa-beer-mug-empty::before {
+  content: "\f0fc"; }
+
+.fa-beer::before {
+  content: "\f0fc"; }
+
+.fa-diagram-predecessor::before {
+  content: "\e477"; }
+
+.fa-arrow-up-long::before {
+  content: "\f176"; }
+
+.fa-long-arrow-up::before {
+  content: "\f176"; }
+
+.fa-fire-flame-simple::before {
+  content: "\f46a"; }
+
+.fa-burn::before {
+  content: "\f46a"; }
+
+.fa-person::before {
+  content: "\f183"; }
+
+.fa-male::before {
+  content: "\f183"; }
+
+.fa-laptop::before {
+  content: "\f109"; }
+
+.fa-file-csv::before {
+  content: "\f6dd"; }
+
+.fa-menorah::before {
+  content: "\f676"; }
+
+.fa-truck-plane::before {
+  content: "\e58f"; }
+
+.fa-record-vinyl::before {
+  content: "\f8d9"; }
+
+.fa-face-grin-stars::before {
+  content: "\f587"; }
+
+.fa-grin-stars::before {
+  content: "\f587"; }
+
+.fa-bong::before {
+  content: "\f55c"; }
+
+.fa-spaghetti-monster-flying::before {
+  content: "\f67b"; }
+
+.fa-pastafarianism::before {
+  content: "\f67b"; }
+
+.fa-arrow-down-up-across-line::before {
+  content: "\e4af"; }
+
+.fa-spoon::before {
+  content: "\f2e5"; }
+
+.fa-utensil-spoon::before {
+  content: "\f2e5"; }
+
+.fa-jar-wheat::before {
+  content: "\e517"; }
+
+.fa-envelopes-bulk::before {
+  content: "\f674"; }
+
+.fa-mail-bulk::before {
+  content: "\f674"; }
+
+.fa-file-circle-exclamation::before {
+  content: "\e4eb"; }
+
+.fa-circle-h::before {
+  content: "\f47e"; }
+
+.fa-hospital-symbol::before {
+  content: "\f47e"; }
+
+.fa-pager::before {
+  content: "\f815"; }
+
+.fa-address-book::before {
+  content: "\f2b9"; }
+
+.fa-contact-book::before {
+  content: "\f2b9"; }
+
+.fa-strikethrough::before {
+  content: "\f0cc"; }
+
+.fa-k::before {
+  content: "\4b"; }
+
+.fa-landmark-flag::before {
+  content: "\e51c"; }
+
+.fa-pencil::before {
+  content: "\f303"; }
+
+.fa-pencil-alt::before {
+  content: "\f303"; }
+
+.fa-backward::before {
+  content: "\f04a"; }
+
+.fa-caret-right::before {
+  content: "\f0da"; }
+
+.fa-comments::before {
+  content: "\f086"; }
+
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+  content: "\f0ea"; }
+
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+  content: "\f0ea"; }
+
+.fa-code-pull-request::before {
+  content: "\e13c"; }
+
+.fa-clipboard-list::before {
+  content: "\f46d"; }
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+.fa-truck-ramp-box::before {
+  content: "\f4de"; }
+
+.fa-truck-loading::before {
+  content: "\f4de"; }
+
+.fa-user-check::before {
+  content: "\f4fc"; }
+
+.fa-vial-virus::before {
+  content: "\e597"; }
+
+.fa-sheet-plastic::before {
+  content: "\e571"; }
+
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+  content: "\f781"; }
+
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+  content: "\f504"; }
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+  content: "\e539"; }
+
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+  content: "\f6a0"; }
+
+.fa-torah::before {
+  content: "\f6a0"; }
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+.fa-broom-ball::before {
+  content: "\f458"; }
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+  content: "\f458"; }
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+  content: "\f458"; }
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+  content: "\f204"; }
+
+.fa-box-archive::before {
+  content: "\f187"; }
+
+.fa-archive::before {
+  content: "\f187"; }
+
+.fa-person-drowning::before {
+  content: "\e545"; }
+
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+  content: "\f886"; }
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+  content: "\f886"; }
+
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+  content: "\f886"; }
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+  content: "\f58a"; }
+
+.fa-grin-tongue-squint::before {
+  content: "\f58a"; }
+
+.fa-spray-can::before {
+  content: "\f5bd"; }
+
+.fa-truck-monster::before {
+  content: "\f63b"; }
+
+.fa-w::before {
+  content: "\57"; }
+
+.fa-earth-africa::before {
+  content: "\f57c"; }
+
+.fa-globe-africa::before {
+  content: "\f57c"; }
+
+.fa-rainbow::before {
+  content: "\f75b"; }
+
+.fa-circle-notch::before {
+  content: "\f1ce"; }
+
+.fa-tablet-screen-button::before {
+  content: "\f3fa"; }
+
+.fa-tablet-alt::before {
+  content: "\f3fa"; }
+
+.fa-paw::before {
+  content: "\f1b0"; }
+
+.fa-cloud::before {
+  content: "\f0c2"; }
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+.fa-trowel-bricks::before {
+  content: "\e58a"; }
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+.fa-face-flushed::before {
+  content: "\f579"; }
+
+.fa-flushed::before {
+  content: "\f579"; }
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+  content: "\f80d"; }
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+  content: "\e57f"; }
+
+.fa-gavel::before {
+  content: "\f0e3"; }
+
+.fa-legal::before {
+  content: "\f0e3"; }
+
+.fa-binoculars::before {
+  content: "\f1e5"; }
+
+.fa-microphone-slash::before {
+  content: "\f131"; }
+
+.fa-box-tissue::before {
+  content: "\e05b"; }
+
+.fa-motorcycle::before {
+  content: "\f21c"; }
+
+.fa-bell-concierge::before {
+  content: "\f562"; }
+
+.fa-concierge-bell::before {
+  content: "\f562"; }
+
+.fa-pen-ruler::before {
+  content: "\f5ae"; }
+
+.fa-pencil-ruler::before {
+  content: "\f5ae"; }
+
+.fa-people-arrows::before {
+  content: "\e068"; }
+
+.fa-people-arrows-left-right::before {
+  content: "\e068"; }
+
+.fa-mars-and-venus-burst::before {
+  content: "\e523"; }
+
+.fa-square-caret-right::before {
+  content: "\f152"; }
+
+.fa-caret-square-right::before {
+  content: "\f152"; }
+
+.fa-scissors::before {
+  content: "\f0c4"; }
+
+.fa-cut::before {
+  content: "\f0c4"; }
+
+.fa-sun-plant-wilt::before {
+  content: "\e57a"; }
+
+.fa-toilets-portable::before {
+  content: "\e584"; }
+
+.fa-hockey-puck::before {
+  content: "\f453"; }
+
+.fa-table::before {
+  content: "\f0ce"; }
+
+.fa-magnifying-glass-arrow-right::before {
+  content: "\e521"; }
+
+.fa-tachograph-digital::before {
+  content: "\f566"; }
+
+.fa-digital-tachograph::before {
+  content: "\f566"; }
+
+.fa-users-slash::before {
+  content: "\e073"; }
+
+.fa-clover::before {
+  content: "\e139"; }
+
+.fa-reply::before {
+  content: "\f3e5"; }
+
+.fa-mail-reply::before {
+  content: "\f3e5"; }
+
+.fa-star-and-crescent::before {
+  content: "\f699"; }
+
+.fa-house-fire::before {
+  content: "\e50c"; }
+
+.fa-square-minus::before {
+  content: "\f146"; }
+
+.fa-minus-square::before {
+  content: "\f146"; }
+
+.fa-helicopter::before {
+  content: "\f533"; }
+
+.fa-compass::before {
+  content: "\f14e"; }
+
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+  content: "\f150"; }
+
+.fa-caret-square-down::before {
+  content: "\f150"; }
+
+.fa-file-circle-question::before {
+  content: "\e4ef"; }
+
+.fa-laptop-code::before {
+  content: "\f5fc"; }
+
+.fa-swatchbook::before {
+  content: "\f5c3"; }
+
+.fa-prescription-bottle::before {
+  content: "\f485"; }
+
+.fa-bars::before {
+  content: "\f0c9"; }
+
+.fa-navicon::before {
+  content: "\f0c9"; }
+
+.fa-people-group::before {
+  content: "\e533"; }
+
+.fa-hourglass-end::before {
+  content: "\f253"; }
+
+.fa-hourglass-3::before {
+  content: "\f253"; }
+
+.fa-heart-crack::before {
+  content: "\f7a9"; }
+
+.fa-heart-broken::before {
+  content: "\f7a9"; }
+
+.fa-square-up-right::before {
+  content: "\f360"; }
+
+.fa-external-link-square-alt::before {
+  content: "\f360"; }
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+.fa-face-kiss-beam::before {
+  content: "\f597"; }
+
+.fa-kiss-beam::before {
+  content: "\f597"; }
+
+.fa-film::before {
+  content: "\f008"; }
+
+.fa-ruler-horizontal::before {
+  content: "\f547"; }
+
+.fa-people-robbery::before {
+  content: "\e536"; }
+
+.fa-lightbulb::before {
+  content: "\f0eb"; }
+
+.fa-caret-left::before {
+  content: "\f0d9"; }
+
+.fa-circle-exclamation::before {
+  content: "\f06a"; }
+
+.fa-exclamation-circle::before {
+  content: "\f06a"; }
+
+.fa-school-circle-xmark::before {
+  content: "\e56d"; }
+
+.fa-arrow-right-from-bracket::before {
+  content: "\f08b"; }
+
+.fa-sign-out::before {
+  content: "\f08b"; }
+
+.fa-circle-chevron-down::before {
+  content: "\f13a"; }
+
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+  content: "\f13a"; }
+
+.fa-unlock-keyhole::before {
+  content: "\f13e"; }
+
+.fa-unlock-alt::before {
+  content: "\f13e"; }
+
+.fa-cloud-showers-heavy::before {
+  content: "\f740"; }
+
+.fa-headphones-simple::before {
+  content: "\f58f"; }
+
+.fa-headphones-alt::before {
+  content: "\f58f"; }
+
+.fa-sitemap::before {
+  content: "\f0e8"; }
+
+.fa-circle-dollar-to-slot::before {
+  content: "\f4b9"; }
+
+.fa-donate::before {
+  content: "\f4b9"; }
+
+.fa-memory::before {
+  content: "\f538"; }
+
+.fa-road-spikes::before {
+  content: "\e568"; }
+
+.fa-fire-burner::before {
+  content: "\e4f1"; }
+
+.fa-flag::before {
+  content: "\f024"; }
+
+.fa-hanukiah::before {
+  content: "\f6e6"; }
+
+.fa-feather::before {
+  content: "\f52d"; }
+
+.fa-volume-low::before {
+  content: "\f027"; }
+
+.fa-volume-down::before {
+  content: "\f027"; }
+
+.fa-comment-slash::before {
+  content: "\f4b3"; }
+
+.fa-cloud-sun-rain::before {
+  content: "\f743"; }
+
+.fa-compress::before {
+  content: "\f066"; }
+
+.fa-wheat-awn::before {
+  content: "\e2cd"; }
+
+.fa-wheat-alt::before {
+  content: "\e2cd"; }
+
+.fa-ankh::before {
+  content: "\f644"; }
+
+.fa-hands-holding-child::before {
+  content: "\e4fa"; }
+
+.fa-asterisk::before {
+  content: "\2a"; }
+
+.fa-square-check::before {
+  content: "\f14a"; }
+
+.fa-check-square::before {
+  content: "\f14a"; }
+
+.fa-peseta-sign::before {
+  content: "\e221"; }
+
+.fa-heading::before {
+  content: "\f1dc"; }
+
+.fa-header::before {
+  content: "\f1dc"; }
+
+.fa-ghost::before {
+  content: "\f6e2"; }
+
+.fa-list::before {
+  content: "\f03a"; }
+
+.fa-list-squares::before {
+  content: "\f03a"; }
+
+.fa-square-phone-flip::before {
+  content: "\f87b"; }
+
+.fa-phone-square-alt::before {
+  content: "\f87b"; }
+
+.fa-cart-plus::before {
+  content: "\f217"; }
+
+.fa-gamepad::before {
+  content: "\f11b"; }
+
+.fa-circle-dot::before {
+  content: "\f192"; }
+
+.fa-dot-circle::before {
+  content: "\f192"; }
+
+.fa-face-dizzy::before {
+  content: "\f567"; }
+
+.fa-dizzy::before {
+  content: "\f567"; }
+
+.fa-egg::before {
+  content: "\f7fb"; }
+
+.fa-house-medical-circle-xmark::before {
+  content: "\e513"; }
+
+.fa-campground::before {
+  content: "\f6bb"; }
+
+.fa-folder-plus::before {
+  content: "\f65e"; }
+
+.fa-futbol::before {
+  content: "\f1e3"; }
+
+.fa-futbol-ball::before {
+  content: "\f1e3"; }
+
+.fa-soccer-ball::before {
+  content: "\f1e3"; }
+
+.fa-paintbrush::before {
+  content: "\f1fc"; }
+
+.fa-paint-brush::before {
+  content: "\f1fc"; }
+
+.fa-lock::before {
+  content: "\f023"; }
+
+.fa-gas-pump::before {
+  content: "\f52f"; }
+
+.fa-hot-tub-person::before {
+  content: "\f593"; }
+
+.fa-hot-tub::before {
+  content: "\f593"; }
+
+.fa-map-location::before {
+  content: "\f59f"; }
+
+.fa-map-marked::before {
+  content: "\f59f"; }
+
+.fa-house-flood-water::before {
+  content: "\e50e"; }
+
+.fa-tree::before {
+  content: "\f1bb"; }
+
+.fa-bridge-lock::before {
+  content: "\e4cc"; }
+
+.fa-sack-dollar::before {
+  content: "\f81d"; }
+
+.fa-pen-to-square::before {
+  content: "\f044"; }
+
+.fa-edit::before {
+  content: "\f044"; }
+
+.fa-car-side::before {
+  content: "\f5e4"; }
+
+.fa-share-nodes::before {
+  content: "\f1e0"; }
+
+.fa-share-alt::before {
+  content: "\f1e0"; }
+
+.fa-heart-circle-minus::before {
+  content: "\e4ff"; }
+
+.fa-hourglass-half::before {
+  content: "\f252"; }
+
+.fa-hourglass-2::before {
+  content: "\f252"; }
+
+.fa-microscope::before {
+  content: "\f610"; }
+
+.fa-sink::before {
+  content: "\e06d"; }
+
+.fa-bag-shopping::before {
+  content: "\f290"; }
+
+.fa-shopping-bag::before {
+  content: "\f290"; }
+
+.fa-arrow-down-z-a::before {
+  content: "\f881"; }
+
+.fa-sort-alpha-desc::before {
+  content: "\f881"; }
+
+.fa-sort-alpha-down-alt::before {
+  content: "\f881"; }
+
+.fa-mitten::before {
+  content: "\f7b5"; }
+
+.fa-person-rays::before {
+  content: "\e54d"; }
+
+.fa-users::before {
+  content: "\f0c0"; }
+
+.fa-eye-slash::before {
+  content: "\f070"; }
+
+.fa-flask-vial::before {
+  content: "\e4f3"; }
+
+.fa-hand::before {
+  content: "\f256"; }
+
+.fa-hand-paper::before {
+  content: "\f256"; }
+
+.fa-om::before {
+  content: "\f679"; }
+
+.fa-worm::before {
+  content: "\e599"; }
+
+.fa-house-circle-xmark::before {
+  content: "\e50b"; }
+
+.fa-plug::before {
+  content: "\f1e6"; }
+
+.fa-chevron-up::before {
+  content: "\f077"; }
+
+.fa-hand-spock::before {
+  content: "\f259"; }
+
+.fa-stopwatch::before {
+  content: "\f2f2"; }
+
+.fa-face-kiss::before {
+  content: "\f596"; }
+
+.fa-kiss::before {
+  content: "\f596"; }
+
+.fa-bridge-circle-xmark::before {
+  content: "\e4cb"; }
+
+.fa-face-grin-tongue::before {
+  content: "\f589"; }
+
+.fa-grin-tongue::before {
+  content: "\f589"; }
+
+.fa-chess-bishop::before {
+  content: "\f43a"; }
+
+.fa-face-grin-wink::before {
+  content: "\f58c"; }
+
+.fa-grin-wink::before {
+  content: "\f58c"; }
+
+.fa-ear-deaf::before {
+  content: "\f2a4"; }
+
+.fa-deaf::before {
+  content: "\f2a4"; }
+
+.fa-deafness::before {
+  content: "\f2a4"; }
+
+.fa-hard-of-hearing::before {
+  content: "\f2a4"; }
+
+.fa-road-circle-check::before {
+  content: "\e564"; }
+
+.fa-dice-five::before {
+  content: "\f523"; }
+
+.fa-square-rss::before {
+  content: "\f143"; }
+
+.fa-rss-square::before {
+  content: "\f143"; }
+
+.fa-land-mine-on::before {
+  content: "\e51b"; }
+
+.fa-i-cursor::before {
+  content: "\f246"; }
+
+.fa-stamp::before {
+  content: "\f5bf"; }
+
+.fa-stairs::before {
+  content: "\e289"; }
+
+.fa-i::before {
+  content: "\49"; }
+
+.fa-hryvnia-sign::before {
+  content: "\f6f2"; }
+
+.fa-hryvnia::before {
+  content: "\f6f2"; }
+
+.fa-pills::before {
+  content: "\f484"; }
+
+.fa-face-grin-wide::before {
+  content: "\f581"; }
+
+.fa-grin-alt::before {
+  content: "\f581"; }
+
+.fa-tooth::before {
+  content: "\f5c9"; }
+
+.fa-v::before {
+  content: "\56"; }
+
+.fa-bangladeshi-taka-sign::before {
+  content: "\e2e6"; }
+
+.fa-bicycle::before {
+  content: "\f206"; }
+
+.fa-staff-snake::before {
+  content: "\e579"; }
+
+.fa-rod-asclepius::before {
+  content: "\e579"; }
+
+.fa-rod-snake::before {
+  content: "\e579"; }
+
+.fa-staff-aesculapius::before {
+  content: "\e579"; }
+
+.fa-head-side-cough-slash::before {
+  content: "\e062"; }
+
+.fa-truck-medical::before {
+  content: "\f0f9"; }
+
+.fa-ambulance::before {
+  content: "\f0f9"; }
+
+.fa-wheat-awn-circle-exclamation::before {
+  content: "\e598"; }
+
+.fa-snowman::before {
+  content: "\f7d0"; }
+
+.fa-mortar-pestle::before {
+  content: "\f5a7"; }
+
+.fa-road-barrier::before {
+  content: "\e562"; }
+
+.fa-school::before {
+  content: "\f549"; }
+
+.fa-igloo::before {
+  content: "\f7ae"; }
+
+.fa-joint::before {
+  content: "\f595"; }
+
+.fa-angle-right::before {
+  content: "\f105"; }
+
+.fa-horse::before {
+  content: "\f6f0"; }
+
+.fa-q::before {
+  content: "\51"; }
+
+.fa-g::before {
+  content: "\47"; }
+
+.fa-notes-medical::before {
+  content: "\f481"; }
+
+.fa-temperature-half::before {
+  content: "\f2c9"; }
+
+.fa-temperature-2::before {
+  content: "\f2c9"; }
+
+.fa-thermometer-2::before {
+  content: "\f2c9"; }
+
+.fa-thermometer-half::before {
+  content: "\f2c9"; }
+
+.fa-dong-sign::before {
+  content: "\e169"; }
+
+.fa-capsules::before {
+  content: "\f46b"; }
+
+.fa-poo-storm::before {
+  content: "\f75a"; }
+
+.fa-poo-bolt::before {
+  content: "\f75a"; }
+
+.fa-face-frown-open::before {
+  content: "\f57a"; }
+
+.fa-frown-open::before {
+  content: "\f57a"; }
+
+.fa-hand-point-up::before {
+  content: "\f0a6"; }
+
+.fa-money-bill::before {
+  content: "\f0d6"; }
+
+.fa-bookmark::before {
+  content: "\f02e"; }
+
+.fa-align-justify::before {
+  content: "\f039"; }
+
+.fa-umbrella-beach::before {
+  content: "\f5ca"; }
+
+.fa-helmet-un::before {
+  content: "\e503"; }
+
+.fa-bullseye::before {
+  content: "\f140"; }
+
+.fa-bacon::before {
+  content: "\f7e5"; }
+
+.fa-hand-point-down::before {
+  content: "\f0a7"; }
+
+.fa-arrow-up-from-bracket::before {
+  content: "\e09a"; }
+
+.fa-folder::before {
+  content: "\f07b"; }
+
+.fa-folder-blank::before {
+  content: "\f07b"; }
+
+.fa-file-waveform::before {
+  content: "\f478"; }
+
+.fa-file-medical-alt::before {
+  content: "\f478"; }
+
+.fa-radiation::before {
+  content: "\f7b9"; }
+
+.fa-chart-simple::before {
+  content: "\e473"; }
+
+.fa-mars-stroke::before {
+  content: "\f229"; }
+
+.fa-vial::before {
+  content: "\f492"; }
+
+.fa-gauge::before {
+  content: "\f624"; }
+
+.fa-dashboard::before {
+  content: "\f624"; }
+
+.fa-gauge-med::before {
+  content: "\f624"; }
+
+.fa-tachometer-alt-average::before {
+  content: "\f624"; }
+
+.fa-wand-magic-sparkles::before {
+  content: "\e2ca"; }
+
+.fa-magic-wand-sparkles::before {
+  content: "\e2ca"; }
+
+.fa-e::before {
+  content: "\45"; }
+
+.fa-pen-clip::before {
+  content: "\f305"; }
+
+.fa-pen-alt::before {
+  content: "\f305"; }
+
+.fa-bridge-circle-exclamation::before {
+  content: "\e4ca"; }
+
+.fa-user::before {
+  content: "\f007"; }
+
+.fa-school-circle-check::before {
+  content: "\e56b"; }
+
+.fa-dumpster::before {
+  content: "\f793"; }
+
+.fa-van-shuttle::before {
+  content: "\f5b6"; }
+
+.fa-shuttle-van::before {
+  content: "\f5b6"; }
+
+.fa-building-user::before {
+  content: "\e4da"; }
+
+.fa-square-caret-left::before {
+  content: "\f191"; }
+
+.fa-caret-square-left::before {
+  content: "\f191"; }
+
+.fa-highlighter::before {
+  content: "\f591"; }
+
+.fa-key::before {
+  content: "\f084"; }
+
+.fa-bullhorn::before {
+  content: "\f0a1"; }
+
+.fa-globe::before {
+  content: "\f0ac"; }
+
+.fa-synagogue::before {
+  content: "\f69b"; }
+
+.fa-person-half-dress::before {
+  content: "\e548"; }
+
+.fa-road-bridge::before {
+  content: "\e563"; }
+
+.fa-location-arrow::before {
+  content: "\f124"; }
+
+.fa-c::before {
+  content: "\43"; }
+
+.fa-tablet-button::before {
+  content: "\f10a"; }
+
+.fa-building-lock::before {
+  content: "\e4d6"; }
+
+.fa-pizza-slice::before {
+  content: "\f818"; }
+
+.fa-money-bill-wave::before {
+  content: "\f53a"; }
+
+.fa-chart-area::before {
+  content: "\f1fe"; }
+
+.fa-area-chart::before {
+  content: "\f1fe"; }
+
+.fa-house-flag::before {
+  content: "\e50d"; }
+
+.fa-person-circle-minus::before {
+  content: "\e540"; }
+
+.fa-ban::before {
+  content: "\f05e"; }
+
+.fa-cancel::before {
+  content: "\f05e"; }
+
+.fa-camera-rotate::before {
+  content: "\e0d8"; }
+
+.fa-spray-can-sparkles::before {
+  content: "\f5d0"; }
+
+.fa-air-freshener::before {
+  content: "\f5d0"; }
+
+.fa-star::before {
+  content: "\f005"; }
+
+.fa-repeat::before {
+  content: "\f363"; }
+
+.fa-cross::before {
+  content: "\f654"; }
+
+.fa-box::before {
+  content: "\f466"; }
+
+.fa-venus-mars::before {
+  content: "\f228"; }
+
+.fa-arrow-pointer::before {
+  content: "\f245"; }
+
+.fa-mouse-pointer::before {
+  content: "\f245"; }
+
+.fa-maximize::before {
+  content: "\f31e"; }
+
+.fa-expand-arrows-alt::before {
+  content: "\f31e"; }
+
+.fa-charging-station::before {
+  content: "\f5e7"; }
+
+.fa-shapes::before {
+  content: "\f61f"; }
+
+.fa-triangle-circle-square::before {
+  content: "\f61f"; }
+
+.fa-shuffle::before {
+  content: "\f074"; }
+
+.fa-random::before {
+  content: "\f074"; }
+
+.fa-person-running::before {
+  content: "\f70c"; }
+
+.fa-running::before {
+  content: "\f70c"; }
+
+.fa-mobile-retro::before {
+  content: "\e527"; }
+
+.fa-grip-lines-vertical::before {
+  content: "\f7a5"; }
+
+.fa-spider::before {
+  content: "\f717"; }
+
+.fa-hands-bound::before {
+  content: "\e4f9"; }
+
+.fa-file-invoice-dollar::before {
+  content: "\f571"; }
+
+.fa-plane-circle-exclamation::before {
+  content: "\e556"; }
+
+.fa-x-ray::before {
+  content: "\f497"; }
+
+.fa-spell-check::before {
+  content: "\f891"; }
+
+.fa-slash::before {
+  content: "\f715"; }
+
+.fa-computer-mouse::before {
+  content: "\f8cc"; }
+
+.fa-mouse::before {
+  content: "\f8cc"; }
+
+.fa-arrow-right-to-bracket::before {
+  content: "\f090"; }
+
+.fa-sign-in::before {
+  content: "\f090"; }
+
+.fa-shop-slash::before {
+  content: "\e070"; }
+
+.fa-store-alt-slash::before {
+  content: "\e070"; }
+
+.fa-server::before {
+  content: "\f233"; }
+
+.fa-virus-covid-slash::before {
+  content: "\e4a9"; }
+
+.fa-shop-lock::before {
+  content: "\e4a5"; }
+
+.fa-hourglass-start::before {
+  content: "\f251"; }
+
+.fa-hourglass-1::before {
+  content: "\f251"; }
+
+.fa-blender-phone::before {
+  content: "\f6b6"; }
+
+.fa-building-wheat::before {
+  content: "\e4db"; }
+
+.fa-person-breastfeeding::before {
+  content: "\e53a"; }
+
+.fa-right-to-bracket::before {
+  content: "\f2f6"; }
+
+.fa-sign-in-alt::before {
+  content: "\f2f6"; }
+
+.fa-venus::before {
+  content: "\f221"; }
+
+.fa-passport::before {
+  content: "\f5ab"; }
+
+.fa-heart-pulse::before {
+  content: "\f21e"; }
+
+.fa-heartbeat::before {
+  content: "\f21e"; }
+
+.fa-people-carry-box::before {
+  content: "\f4ce"; }
+
+.fa-people-carry::before {
+  content: "\f4ce"; }
+
+.fa-temperature-high::before {
+  content: "\f769"; }
+
+.fa-microchip::before {
+  content: "\f2db"; }
+
+.fa-crown::before {
+  content: "\f521"; }
+
+.fa-weight-hanging::before {
+  content: "\f5cd"; }
+
+.fa-xmarks-lines::before {
+  content: "\e59a"; }
+
+.fa-file-prescription::before {
+  content: "\f572"; }
+
+.fa-weight-scale::before {
+  content: "\f496"; }
+
+.fa-weight::before {
+  content: "\f496"; }
+
+.fa-user-group::before {
+  content: "\f500"; }
+
+.fa-user-friends::before {
+  content: "\f500"; }
+
+.fa-arrow-up-a-z::before {
+  content: "\f15e"; }
+
+.fa-sort-alpha-up::before {
+  content: "\f15e"; }
+
+.fa-chess-knight::before {
+  content: "\f441"; }
+
+.fa-face-laugh-squint::before {
+  content: "\f59b"; }
+
+.fa-laugh-squint::before {
+  content: "\f59b"; }
+
+.fa-wheelchair::before {
+  content: "\f193"; }
+
+.fa-circle-arrow-up::before {
+  content: "\f0aa"; }
+
+.fa-arrow-circle-up::before {
+  content: "\f0aa"; }
+
+.fa-toggle-on::before {
+  content: "\f205"; }
+
+.fa-person-walking::before {
+  content: "\f554"; }
+
+.fa-walking::before {
+  content: "\f554"; }
+
+.fa-l::before {
+  content: "\4c"; }
+
+.fa-fire::before {
+  content: "\f06d"; }
+
+.fa-bed-pulse::before {
+  content: "\f487"; }
+
+.fa-procedures::before {
+  content: "\f487"; }
+
+.fa-shuttle-space::before {
+  content: "\f197"; }
+
+.fa-space-shuttle::before {
+  content: "\f197"; }
+
+.fa-face-laugh::before {
+  content: "\f599"; }
+
+.fa-laugh::before {
+  content: "\f599"; }
+
+.fa-folder-open::before {
+  content: "\f07c"; }
+
+.fa-heart-circle-plus::before {
+  content: "\e500"; }
+
+.fa-code-fork::before {
+  content: "\e13b"; }
+
+.fa-city::before {
+  content: "\f64f"; }
+
+.fa-microphone-lines::before {
+  content: "\f3c9"; }
+
+.fa-microphone-alt::before {
+  content: "\f3c9"; }
+
+.fa-pepper-hot::before {
+  content: "\f816"; }
+
+.fa-unlock::before {
+  content: "\f09c"; }
+
+.fa-colon-sign::before {
+  content: "\e140"; }
+
+.fa-headset::before {
+  content: "\f590"; }
+
+.fa-store-slash::before {
+  content: "\e071"; }
+
+.fa-road-circle-xmark::before {
+  content: "\e566"; }
+
+.fa-user-minus::before {
+  content: "\f503"; }
+
+.fa-mars-stroke-up::before {
+  content: "\f22a"; }
+
+.fa-mars-stroke-v::before {
+  content: "\f22a"; }
+
+.fa-champagne-glasses::before {
+  content: "\f79f"; }
+
+.fa-glass-cheers::before {
+  content: "\f79f"; }
+
+.fa-clipboard::before {
+  content: "\f328"; }
+
+.fa-house-circle-exclamation::before {
+  content: "\e50a"; }
+
+.fa-file-arrow-up::before {
+  content: "\f574"; }
+
+.fa-file-upload::before {
+  content: "\f574"; }
+
+.fa-wifi::before {
+  content: "\f1eb"; }
+
+.fa-wifi-3::before {
+  content: "\f1eb"; }
+
+.fa-wifi-strong::before {
+  content: "\f1eb"; }
+
+.fa-bath::before {
+  content: "\f2cd"; }
+
+.fa-bathtub::before {
+  content: "\f2cd"; }
+
+.fa-underline::before {
+  content: "\f0cd"; }
+
+.fa-user-pen::before {
+  content: "\f4ff"; }
+
+.fa-user-edit::before {
+  content: "\f4ff"; }
+
+.fa-signature::before {
+  content: "\f5b7"; }
+
+.fa-stroopwafel::before {
+  content: "\f551"; }
+
+.fa-bold::before {
+  content: "\f032"; }
+
+.fa-anchor-lock::before {
+  content: "\e4ad"; }
+
+.fa-building-ngo::before {
+  content: "\e4d7"; }
+
+.fa-manat-sign::before {
+  content: "\e1d5"; }
+
+.fa-not-equal::before {
+  content: "\f53e"; }
+
+.fa-border-top-left::before {
+  content: "\f853"; }
+
+.fa-border-style::before {
+  content: "\f853"; }
+
+.fa-map-location-dot::before {
+  content: "\f5a0"; }
+
+.fa-map-marked-alt::before {
+  content: "\f5a0"; }
+
+.fa-jedi::before {
+  content: "\f669"; }
+
+.fa-square-poll-vertical::before {
+  content: "\f681"; }
+
+.fa-poll::before {
+  content: "\f681"; }
+
+.fa-mug-hot::before {
+  content: "\f7b6"; }
+
+.fa-car-battery::before {
+  content: "\f5df"; }
+
+.fa-battery-car::before {
+  content: "\f5df"; }
+
+.fa-gift::before {
+  content: "\f06b"; }
+
+.fa-dice-two::before {
+  content: "\f528"; }
+
+.fa-chess-queen::before {
+  content: "\f445"; }
+
+.fa-glasses::before {
+  content: "\f530"; }
+
+.fa-chess-board::before {
+  content: "\f43c"; }
+
+.fa-building-circle-check::before {
+  content: "\e4d2"; }
+
+.fa-person-chalkboard::before {
+  content: "\e53d"; }
+
+.fa-mars-stroke-right::before {
+  content: "\f22b"; }
+
+.fa-mars-stroke-h::before {
+  content: "\f22b"; }
+
+.fa-hand-back-fist::before {
+  content: "\f255"; }
+
+.fa-hand-rock::before {
+  content: "\f255"; }
+
+.fa-square-caret-up::before {
+  content: "\f151"; }
+
+.fa-caret-square-up::before {
+  content: "\f151"; }
+
+.fa-cloud-showers-water::before {
+  content: "\e4e4"; }
+
+.fa-chart-bar::before {
+  content: "\f080"; }
+
+.fa-bar-chart::before {
+  content: "\f080"; }
+
+.fa-hands-bubbles::before {
+  content: "\e05e"; }
+
+.fa-hands-wash::before {
+  content: "\e05e"; }
+
+.fa-less-than-equal::before {
+  content: "\f537"; }
+
+.fa-train::before {
+  content: "\f238"; }
+
+.fa-eye-low-vision::before {
+  content: "\f2a8"; }
+
+.fa-low-vision::before {
+  content: "\f2a8"; }
+
+.fa-crow::before {
+  content: "\f520"; }
+
+.fa-sailboat::before {
+  content: "\e445"; }
+
+.fa-window-restore::before {
+  content: "\f2d2"; }
+
+.fa-square-plus::before {
+  content: "\f0fe"; }
+
+.fa-plus-square::before {
+  content: "\f0fe"; }
+
+.fa-torii-gate::before {
+  content: "\f6a1"; }
+
+.fa-frog::before {
+  content: "\f52e"; }
+
+.fa-bucket::before {
+  content: "\e4cf"; }
+
+.fa-image::before {
+  content: "\f03e"; }
+
+.fa-microphone::before {
+  content: "\f130"; }
+
+.fa-cow::before {
+  content: "\f6c8"; }
+
+.fa-caret-up::before {
+  content: "\f0d8"; }
+
+.fa-screwdriver::before {
+  content: "\f54a"; }
+
+.fa-folder-closed::before {
+  content: "\e185"; }
+
+.fa-house-tsunami::before {
+  content: "\e515"; }
+
+.fa-square-nfi::before {
+  content: "\e576"; }
+
+.fa-arrow-up-from-ground-water::before {
+  content: "\e4b5"; }
+
+.fa-martini-glass::before {
+  content: "\f57b"; }
+
+.fa-glass-martini-alt::before {
+  content: "\f57b"; }
+
+.fa-rotate-left::before {
+  content: "\f2ea"; }
+
+.fa-rotate-back::before {
+  content: "\f2ea"; }
+
+.fa-rotate-backward::before {
+  content: "\f2ea"; }
+
+.fa-undo-alt::before {
+  content: "\f2ea"; }
+
+.fa-table-columns::before {
+  content: "\f0db"; }
+
+.fa-columns::before {
+  content: "\f0db"; }
+
+.fa-lemon::before {
+  content: "\f094"; }
+
+.fa-head-side-mask::before {
+  content: "\e063"; }
+
+.fa-handshake::before {
+  content: "\f2b5"; }
+
+.fa-gem::before {
+  content: "\f3a5"; }
+
+.fa-dolly::before {
+  content: "\f472"; }
+
+.fa-dolly-box::before {
+  content: "\f472"; }
+
+.fa-smoking::before {
+  content: "\f48d"; }
+
+.fa-minimize::before {
+  content: "\f78c"; }
+
+.fa-compress-arrows-alt::before {
+  content: "\f78c"; }
+
+.fa-monument::before {
+  content: "\f5a6"; }
+
+.fa-snowplow::before {
+  content: "\f7d2"; }
+
+.fa-angles-right::before {
+  content: "\f101"; }
+
+.fa-angle-double-right::before {
+  content: "\f101"; }
+
+.fa-cannabis::before {
+  content: "\f55f"; }
+
+.fa-circle-play::before {
+  content: "\f144"; }
+
+.fa-play-circle::before {
+  content: "\f144"; }
+
+.fa-tablets::before {
+  content: "\f490"; }
+
+.fa-ethernet::before {
+  content: "\f796"; }
+
+.fa-euro-sign::before {
+  content: "\f153"; }
+
+.fa-eur::before {
+  content: "\f153"; }
+
+.fa-euro::before {
+  content: "\f153"; }
+
+.fa-chair::before {
+  content: "\f6c0"; }
+
+.fa-circle-check::before {
+  content: "\f058"; }
+
+.fa-check-circle::before {
+  content: "\f058"; }
+
+.fa-circle-stop::before {
+  content: "\f28d"; }
+
+.fa-stop-circle::before {
+  content: "\f28d"; }
+
+.fa-compass-drafting::before {
+  content: "\f568"; }
+
+.fa-drafting-compass::before {
+  content: "\f568"; }
+
+.fa-plate-wheat::before {
+  content: "\e55a"; }
+
+.fa-icicles::before {
+  content: "\f7ad"; }
+
+.fa-person-shelter::before {
+  content: "\e54f"; }
+
+.fa-neuter::before {
+  content: "\f22c"; }
+
+.fa-id-badge::before {
+  content: "\f2c1"; }
+
+.fa-marker::before {
+  content: "\f5a1"; }
+
+.fa-face-laugh-beam::before {
+  content: "\f59a"; }
+
+.fa-laugh-beam::before {
+  content: "\f59a"; }
+
+.fa-helicopter-symbol::before {
+  content: "\e502"; }
+
+.fa-universal-access::before {
+  content: "\f29a"; }
+
+.fa-circle-chevron-up::before {
+  content: "\f139"; }
+
+.fa-chevron-circle-up::before {
+  content: "\f139"; }
+
+.fa-lari-sign::before {
+  content: "\e1c8"; }
+
+.fa-volcano::before {
+  content: "\f770"; }
+
+.fa-person-walking-dashed-line-arrow-right::before {
+  content: "\e553"; }
+
+.fa-sterling-sign::before {
+  content: "\f154"; }
+
+.fa-gbp::before {
+  content: "\f154"; }
+
+.fa-pound-sign::before {
+  content: "\f154"; }
+
+.fa-viruses::before {
+  content: "\e076"; }
+
+.fa-square-person-confined::before {
+  content: "\e577"; }
+
+.fa-user-tie::before {
+  content: "\f508"; }
+
+.fa-arrow-down-long::before {
+  content: "\f175"; }
+
+.fa-long-arrow-down::before {
+  content: "\f175"; }
+
+.fa-tent-arrow-down-to-line::before {
+  content: "\e57e"; }
+
+.fa-certificate::before {
+  content: "\f0a3"; }
+
+.fa-reply-all::before {
+  content: "\f122"; }
+
+.fa-mail-reply-all::before {
+  content: "\f122"; }
+
+.fa-suitcase::before {
+  content: "\f0f2"; }
+
+.fa-person-skating::before {
+  content: "\f7c5"; }
+
+.fa-skating::before {
+  content: "\f7c5"; }
+
+.fa-filter-circle-dollar::before {
+  content: "\f662"; }
+
+.fa-funnel-dollar::before {
+  content: "\f662"; }
+
+.fa-camera-retro::before {
+  content: "\f083"; }
+
+.fa-circle-arrow-down::before {
+  content: "\f0ab"; }
+
+.fa-arrow-circle-down::before {
+  content: "\f0ab"; }
+
+.fa-file-import::before {
+  content: "\f56f"; }
+
+.fa-arrow-right-to-file::before {
+  content: "\f56f"; }
+
+.fa-square-arrow-up-right::before {
+  content: "\f14c"; }
+
+.fa-external-link-square::before {
+  content: "\f14c"; }
+
+.fa-box-open::before {
+  content: "\f49e"; }
+
+.fa-scroll::before {
+  content: "\f70e"; }
+
+.fa-spa::before {
+  content: "\f5bb"; }
+
+.fa-location-pin-lock::before {
+  content: "\e51f"; }
+
+.fa-pause::before {
+  content: "\f04c"; }
+
+.fa-hill-avalanche::before {
+  content: "\e507"; }
+
+.fa-temperature-empty::before {
+  content: "\f2cb"; }
+
+.fa-temperature-0::before {
+  content: "\f2cb"; }
+
+.fa-thermometer-0::before {
+  content: "\f2cb"; }
+
+.fa-thermometer-empty::before {
+  content: "\f2cb"; }
+
+.fa-bomb::before {
+  content: "\f1e2"; }
+
+.fa-registered::before {
+  content: "\f25d"; }
+
+.fa-address-card::before {
+  content: "\f2bb"; }
+
+.fa-contact-card::before {
+  content: "\f2bb"; }
+
+.fa-vcard::before {
+  content: "\f2bb"; }
+
+.fa-scale-unbalanced-flip::before {
+  content: "\f516"; }
+
+.fa-balance-scale-right::before {
+  content: "\f516"; }
+
+.fa-subscript::before {
+  content: "\f12c"; }
+
+.fa-diamond-turn-right::before {
+  content: "\f5eb"; }
+
+.fa-directions::before {
+  content: "\f5eb"; }
+
+.fa-burst::before {
+  content: "\e4dc"; }
+
+.fa-house-laptop::before {
+  content: "\e066"; }
+
+.fa-laptop-house::before {
+  content: "\e066"; }
+
+.fa-face-tired::before {
+  content: "\f5c8"; }
+
+.fa-tired::before {
+  content: "\f5c8"; }
+
+.fa-money-bills::before {
+  content: "\e1f3"; }
+
+.fa-smog::before {
+  content: "\f75f"; }
+
+.fa-crutch::before {
+  content: "\f7f7"; }
+
+.fa-cloud-arrow-up::before {
+  content: "\f0ee"; }
+
+.fa-cloud-upload::before {
+  content: "\f0ee"; }
+
+.fa-cloud-upload-alt::before {
+  content: "\f0ee"; }
+
+.fa-palette::before {
+  content: "\f53f"; }
+
+.fa-arrows-turn-right::before {
+  content: "\e4c0"; }
+
+.fa-vest::before {
+  content: "\e085"; }
+
+.fa-ferry::before {
+  content: "\e4ea"; }
+
+.fa-arrows-down-to-people::before {
+  content: "\e4b9"; }
+
+.fa-seedling::before {
+  content: "\f4d8"; }
+
+.fa-sprout::before {
+  content: "\f4d8"; }
+
+.fa-left-right::before {
+  content: "\f337"; }
+
+.fa-arrows-alt-h::before {
+  content: "\f337"; }
+
+.fa-boxes-packing::before {
+  content: "\e4c7"; }
+
+.fa-circle-arrow-left::before {
+  content: "\f0a8"; }
+
+.fa-arrow-circle-left::before {
+  content: "\f0a8"; }
+
+.fa-group-arrows-rotate::before {
+  content: "\e4f6"; }
+
+.fa-bowl-food::before {
+  content: "\e4c6"; }
+
+.fa-candy-cane::before {
+  content: "\f786"; }
+
+.fa-arrow-down-wide-short::before {
+  content: "\f160"; }
+
+.fa-sort-amount-asc::before {
+  content: "\f160"; }
+
+.fa-sort-amount-down::before {
+  content: "\f160"; }
+
+.fa-cloud-bolt::before {
+  content: "\f76c"; }
+
+.fa-thunderstorm::before {
+  content: "\f76c"; }
+
+.fa-text-slash::before {
+  content: "\f87d"; }
+
+.fa-remove-format::before {
+  content: "\f87d"; }
+
+.fa-face-smile-wink::before {
+  content: "\f4da"; }
+
+.fa-smile-wink::before {
+  content: "\f4da"; }
+
+.fa-file-word::before {
+  content: "\f1c2"; }
+
+.fa-file-powerpoint::before {
+  content: "\f1c4"; }
+
+.fa-arrows-left-right::before {
+  content: "\f07e"; }
+
+.fa-arrows-h::before {
+  content: "\f07e"; }
+
+.fa-house-lock::before {
+  content: "\e510"; }
+
+.fa-cloud-arrow-down::before {
+  content: "\f0ed"; }
+
+.fa-cloud-download::before {
+  content: "\f0ed"; }
+
+.fa-cloud-download-alt::before {
+  content: "\f0ed"; }
+
+.fa-children::before {
+  content: "\e4e1"; }
+
+.fa-chalkboard::before {
+  content: "\f51b"; }
+
+.fa-blackboard::before {
+  content: "\f51b"; }
+
+.fa-user-large-slash::before {
+  content: "\f4fa"; }
+
+.fa-user-alt-slash::before {
+  content: "\f4fa"; }
+
+.fa-envelope-open::before {
+  content: "\f2b6"; }
+
+.fa-handshake-simple-slash::before {
+  content: "\e05f"; }
+
+.fa-handshake-alt-slash::before {
+  content: "\e05f"; }
+
+.fa-mattress-pillow::before {
+  content: "\e525"; }
+
+.fa-guarani-sign::before {
+  content: "\e19a"; }
+
+.fa-arrows-rotate::before {
+  content: "\f021"; }
+
+.fa-refresh::before {
+  content: "\f021"; }
+
+.fa-sync::before {
+  content: "\f021"; }
+
+.fa-fire-extinguisher::before {
+  content: "\f134"; }
+
+.fa-cruzeiro-sign::before {
+  content: "\e152"; }
+
+.fa-greater-than-equal::before {
+  content: "\f532"; }
+
+.fa-shield-halved::before {
+  content: "\f3ed"; }
+
+.fa-shield-alt::before {
+  content: "\f3ed"; }
+
+.fa-book-atlas::before {
+  content: "\f558"; }
+
+.fa-atlas::before {
+  content: "\f558"; }
+
+.fa-virus::before {
+  content: "\e074"; }
+
+.fa-envelope-circle-check::before {
+  content: "\e4e8"; }
+
+.fa-layer-group::before {
+  content: "\f5fd"; }
+
+.fa-arrows-to-dot::before {
+  content: "\e4be"; }
+
+.fa-archway::before {
+  content: "\f557"; }
+
+.fa-heart-circle-check::before {
+  content: "\e4fd"; }
+
+.fa-house-chimney-crack::before {
+  content: "\f6f1"; }
+
+.fa-house-damage::before {
+  content: "\f6f1"; }
+
+.fa-file-zipper::before {
+  content: "\f1c6"; }
+
+.fa-file-archive::before {
+  content: "\f1c6"; }
+
+.fa-square::before {
+  content: "\f0c8"; }
+
+.fa-martini-glass-empty::before {
+  content: "\f000"; }
+
+.fa-glass-martini::before {
+  content: "\f000"; }
+
+.fa-couch::before {
+  content: "\f4b8"; }
+
+.fa-cedi-sign::before {
+  content: "\e0df"; }
+
+.fa-italic::before {
+  content: "\f033"; }
+
+.fa-church::before {
+  content: "\f51d"; }
+
+.fa-comments-dollar::before {
+  content: "\f653"; }
+
+.fa-democrat::before {
+  content: "\f747"; }
+
+.fa-z::before {
+  content: "\5a"; }
+
+.fa-person-skiing::before {
+  content: "\f7c9"; }
+
+.fa-skiing::before {
+  content: "\f7c9"; }
+
+.fa-road-lock::before {
+  content: "\e567"; }
+
+.fa-a::before {
+  content: "\41"; }
+
+.fa-temperature-arrow-down::before {
+  content: "\e03f"; }
+
+.fa-temperature-down::before {
+  content: "\e03f"; }
+
+.fa-feather-pointed::before {
+  content: "\f56b"; }
+
+.fa-feather-alt::before {
+  content: "\f56b"; }
+
+.fa-p::before {
+  content: "\50"; }
+
+.fa-snowflake::before {
+  content: "\f2dc"; }
+
+.fa-newspaper::before {
+  content: "\f1ea"; }
+
+.fa-rectangle-ad::before {
+  content: "\f641"; }
+
+.fa-ad::before {
+  content: "\f641"; }
+
+.fa-circle-arrow-right::before {
+  content: "\f0a9"; }
+
+.fa-arrow-circle-right::before {
+  content: "\f0a9"; }
+
+.fa-filter-circle-xmark::before {
+  content: "\e17b"; }
+
+.fa-locust::before {
+  content: "\e520"; }
+
+.fa-sort::before {
+  content: "\f0dc"; }
+
+.fa-unsorted::before {
+  content: "\f0dc"; }
+
+.fa-list-ol::before {
+  content: "\f0cb"; }
+
+.fa-list-1-2::before {
+  content: "\f0cb"; }
+
+.fa-list-numeric::before {
+  content: "\f0cb"; }
+
+.fa-person-dress-burst::before {
+  content: "\e544"; }
+
+.fa-money-check-dollar::before {
+  content: "\f53d"; }
+
+.fa-money-check-alt::before {
+  content: "\f53d"; }
+
+.fa-vector-square::before {
+  content: "\f5cb"; }
+
+.fa-bread-slice::before {
+  content: "\f7ec"; }
+
+.fa-language::before {
+  content: "\f1ab"; }
+
+.fa-face-kiss-wink-heart::before {
+  content: "\f598"; }
+
+.fa-kiss-wink-heart::before {
+  content: "\f598"; }
+
+.fa-filter::before {
+  content: "\f0b0"; }
+
+.fa-question::before {
+  content: "\3f"; }
+
+.fa-file-signature::before {
+  content: "\f573"; }
+
+.fa-up-down-left-right::before {
+  content: "\f0b2"; }
+
+.fa-arrows-alt::before {
+  content: "\f0b2"; }
+
+.fa-house-chimney-user::before {
+  content: "\e065"; }
+
+.fa-hand-holding-heart::before {
+  content: "\f4be"; }
+
+.fa-puzzle-piece::before {
+  content: "\f12e"; }
+
+.fa-money-check::before {
+  content: "\f53c"; }
+
+.fa-star-half-stroke::before {
+  content: "\f5c0"; }
+
+.fa-star-half-alt::before {
+  content: "\f5c0"; }
+
+.fa-code::before {
+  content: "\f121"; }
+
+.fa-whiskey-glass::before {
+  content: "\f7a0"; }
+
+.fa-glass-whiskey::before {
+  content: "\f7a0"; }
+
+.fa-building-circle-exclamation::before {
+  content: "\e4d3"; }
+
+.fa-magnifying-glass-chart::before {
+  content: "\e522"; }
+
+.fa-arrow-up-right-from-square::before {
+  content: "\f08e"; }
+
+.fa-external-link::before {
+  content: "\f08e"; }
+
+.fa-cubes-stacked::before {
+  content: "\e4e6"; }
+
+.fa-won-sign::before {
+  content: "\f159"; }
+
+.fa-krw::before {
+  content: "\f159"; }
+
+.fa-won::before {
+  content: "\f159"; }
+
+.fa-virus-covid::before {
+  content: "\e4a8"; }
+
+.fa-austral-sign::before {
+  content: "\e0a9"; }
+
+.fa-f::before {
+  content: "\46"; }
+
+.fa-leaf::before {
+  content: "\f06c"; }
+
+.fa-road::before {
+  content: "\f018"; }
+
+.fa-taxi::before {
+  content: "\f1ba"; }
+
+.fa-cab::before {
+  content: "\f1ba"; }
+
+.fa-person-circle-plus::before {
+  content: "\e541"; }
+
+.fa-chart-pie::before {
+  content: "\f200"; }
+
+.fa-pie-chart::before {
+  content: "\f200"; }
+
+.fa-bolt-lightning::before {
+  content: "\e0b7"; }
+
+.fa-sack-xmark::before {
+  content: "\e56a"; }
+
+.fa-file-excel::before {
+  content: "\f1c3"; }
+
+.fa-file-contract::before {
+  content: "\f56c"; }
+
+.fa-fish-fins::before {
+  content: "\e4f2"; }
+
+.fa-building-flag::before {
+  content: "\e4d5"; }
+
+.fa-face-grin-beam::before {
+  content: "\f582"; }
+
+.fa-grin-beam::before {
+  content: "\f582"; }
+
+.fa-object-ungroup::before {
+  content: "\f248"; }
+
+.fa-poop::before {
+  content: "\f619"; }
+
+.fa-location-pin::before {
+  content: "\f041"; }
+
+.fa-map-marker::before {
+  content: "\f041"; }
+
+.fa-kaaba::before {
+  content: "\f66b"; }
+
+.fa-toilet-paper::before {
+  content: "\f71e"; }
+
+.fa-helmet-safety::before {
+  content: "\f807"; }
+
+.fa-hard-hat::before {
+  content: "\f807"; }
+
+.fa-hat-hard::before {
+  content: "\f807"; }
+
+.fa-eject::before {
+  content: "\f052"; }
+
+.fa-circle-right::before {
+  content: "\f35a"; }
+
+.fa-arrow-alt-circle-right::before {
+  content: "\f35a"; }
+
+.fa-plane-circle-check::before {
+  content: "\e555"; }
+
+.fa-face-rolling-eyes::before {
+  content: "\f5a5"; }
+
+.fa-meh-rolling-eyes::before {
+  content: "\f5a5"; }
+
+.fa-object-group::before {
+  content: "\f247"; }
+
+.fa-chart-line::before {
+  content: "\f201"; }
+
+.fa-line-chart::before {
+  content: "\f201"; }
+
+.fa-mask-ventilator::before {
+  content: "\e524"; }
+
+.fa-arrow-right::before {
+  content: "\f061"; }
+
+.fa-signs-post::before {
+  content: "\f277"; }
+
+.fa-map-signs::before {
+  content: "\f277"; }
+
+.fa-cash-register::before {
+  content: "\f788"; }
+
+.fa-person-circle-question::before {
+  content: "\e542"; }
+
+.fa-h::before {
+  content: "\48"; }
+
+.fa-tarp::before {
+  content: "\e57b"; }
+
+.fa-screwdriver-wrench::before {
+  content: "\f7d9"; }
+
+.fa-tools::before {
+  content: "\f7d9"; }
+
+.fa-arrows-to-eye::before {
+  content: "\e4bf"; }
+
+.fa-plug-circle-bolt::before {
+  content: "\e55b"; }
+
+.fa-heart::before {
+  content: "\f004"; }
+
+.fa-mars-and-venus::before {
+  content: "\f224"; }
+
+.fa-house-user::before {
+  content: "\e1b0"; }
+
+.fa-home-user::before {
+  content: "\e1b0"; }
+
+.fa-dumpster-fire::before {
+  content: "\f794"; }
+
+.fa-house-crack::before {
+  content: "\e3b1"; }
+
+.fa-martini-glass-citrus::before {
+  content: "\f561"; }
+
+.fa-cocktail::before {
+  content: "\f561"; }
+
+.fa-face-surprise::before {
+  content: "\f5c2"; }
+
+.fa-surprise::before {
+  content: "\f5c2"; }
+
+.fa-bottle-water::before {
+  content: "\e4c5"; }
+
+.fa-circle-pause::before {
+  content: "\f28b"; }
+
+.fa-pause-circle::before {
+  content: "\f28b"; }
+
+.fa-toilet-paper-slash::before {
+  content: "\e072"; }
+
+.fa-apple-whole::before {
+  content: "\f5d1"; }
+
+.fa-apple-alt::before {
+  content: "\f5d1"; }
+
+.fa-kitchen-set::before {
+  content: "\e51a"; }
+
+.fa-r::before {
+  content: "\52"; }
+
+.fa-temperature-quarter::before {
+  content: "\f2ca"; }
+
+.fa-temperature-1::before {
+  content: "\f2ca"; }
+
+.fa-thermometer-1::before {
+  content: "\f2ca"; }
+
+.fa-thermometer-quarter::before {
+  content: "\f2ca"; }
+
+.fa-cube::before {
+  content: "\f1b2"; }
+
+.fa-bitcoin-sign::before {
+  content: "\e0b4"; }
+
+.fa-shield-dog::before {
+  content: "\e573"; }
+
+.fa-solar-panel::before {
+  content: "\f5ba"; }
+
+.fa-lock-open::before {
+  content: "\f3c1"; }
+
+.fa-elevator::before {
+  content: "\e16d"; }
+
+.fa-money-bill-transfer::before {
+  content: "\e528"; }
+
+.fa-money-bill-trend-up::before {
+  content: "\e529"; }
+
+.fa-house-flood-water-circle-arrow-right::before {
+  content: "\e50f"; }
+
+.fa-square-poll-horizontal::before {
+  content: "\f682"; }
+
+.fa-poll-h::before {
+  content: "\f682"; }
+
+.fa-circle::before {
+  content: "\f111"; }
+
+.fa-backward-fast::before {
+  content: "\f049"; }
+
+.fa-fast-backward::before {
+  content: "\f049"; }
+
+.fa-recycle::before {
+  content: "\f1b8"; }
+
+.fa-user-astronaut::before {
+  content: "\f4fb"; }
+
+.fa-plane-slash::before {
+  content: "\e069"; }
+
+.fa-trademark::before {
+  content: "\f25c"; }
+
+.fa-basketball::before {
+  content: "\f434"; }
+
+.fa-basketball-ball::before {
+  content: "\f434"; }
+
+.fa-satellite-dish::before {
+  content: "\f7c0"; }
+
+.fa-circle-up::before {
+  content: "\f35b"; }
+
+.fa-arrow-alt-circle-up::before {
+  content: "\f35b"; }
+
+.fa-mobile-screen-button::before {
+  content: "\f3cd"; }
+
+.fa-mobile-alt::before {
+  content: "\f3cd"; }
+
+.fa-volume-high::before {
+  content: "\f028"; }
+
+.fa-volume-up::before {
+  content: "\f028"; }
+
+.fa-users-rays::before {
+  content: "\e593"; }
+
+.fa-wallet::before {
+  content: "\f555"; }
+
+.fa-clipboard-check::before {
+  content: "\f46c"; }
+
+.fa-file-audio::before {
+  content: "\f1c7"; }
+
+.fa-burger::before {
+  content: "\f805"; }
+
+.fa-hamburger::before {
+  content: "\f805"; }
+
+.fa-wrench::before {
+  content: "\f0ad"; }
+
+.fa-bugs::before {
+  content: "\e4d0"; }
+
+.fa-rupee-sign::before {
+  content: "\f156"; }
+
+.fa-rupee::before {
+  content: "\f156"; }
+
+.fa-file-image::before {
+  content: "\f1c5"; }
+
+.fa-circle-question::before {
+  content: "\f059"; }
+
+.fa-question-circle::before {
+  content: "\f059"; }
+
+.fa-plane-departure::before {
+  content: "\f5b0"; }
+
+.fa-handshake-slash::before {
+  content: "\e060"; }
+
+.fa-book-bookmark::before {
+  content: "\e0bb"; }
+
+.fa-code-branch::before {
+  content: "\f126"; }
+
+.fa-hat-cowboy::before {
+  content: "\f8c0"; }
+
+.fa-bridge::before {
+  content: "\e4c8"; }
+
+.fa-phone-flip::before {
+  content: "\f879"; }
+
+.fa-phone-alt::before {
+  content: "\f879"; }
+
+.fa-truck-front::before {
+  content: "\e2b7"; }
+
+.fa-cat::before {
+  content: "\f6be"; }
+
+.fa-anchor-circle-exclamation::before {
+  content: "\e4ab"; }
+
+.fa-truck-field::before {
+  content: "\e58d"; }
+
+.fa-route::before {
+  content: "\f4d7"; }
+
+.fa-clipboard-question::before {
+  content: "\e4e3"; }
+
+.fa-panorama::before {
+  content: "\e209"; }
+
+.fa-comment-medical::before {
+  content: "\f7f5"; }
+
+.fa-teeth-open::before {
+  content: "\f62f"; }
+
+.fa-file-circle-minus::before {
+  content: "\e4ed"; }
+
+.fa-tags::before {
+  content: "\f02c"; }
+
+.fa-wine-glass::before {
+  content: "\f4e3"; }
+
+.fa-forward-fast::before {
+  content: "\f050"; }
+
+.fa-fast-forward::before {
+  content: "\f050"; }
+
+.fa-face-meh-blank::before {
+  content: "\f5a4"; }
+
+.fa-meh-blank::before {
+  content: "\f5a4"; }
+
+.fa-square-parking::before {
+  content: "\f540"; }
+
+.fa-parking::before {
+  content: "\f540"; }
+
+.fa-house-signal::before {
+  content: "\e012"; }
+
+.fa-bars-progress::before {
+  content: "\f828"; }
+
+.fa-tasks-alt::before {
+  content: "\f828"; }
+
+.fa-faucet-drip::before {
+  content: "\e006"; }
+
+.fa-cart-flatbed::before {
+  content: "\f474"; }
+
+.fa-dolly-flatbed::before {
+  content: "\f474"; }
+
+.fa-ban-smoking::before {
+  content: "\f54d"; }
+
+.fa-smoking-ban::before {
+  content: "\f54d"; }
+
+.fa-terminal::before {
+  content: "\f120"; }
+
+.fa-mobile-button::before {
+  content: "\f10b"; }
+
+.fa-house-medical-flag::before {
+  content: "\e514"; }
+
+.fa-basket-shopping::before {
+  content: "\f291"; }
+
+.fa-shopping-basket::before {
+  content: "\f291"; }
+
+.fa-tape::before {
+  content: "\f4db"; }
+
+.fa-bus-simple::before {
+  content: "\f55e"; }
+
+.fa-bus-alt::before {
+  content: "\f55e"; }
+
+.fa-eye::before {
+  content: "\f06e"; }
+
+.fa-face-sad-cry::before {
+  content: "\f5b3"; }
+
+.fa-sad-cry::before {
+  content: "\f5b3"; }
+
+.fa-audio-description::before {
+  content: "\f29e"; }
+
+.fa-person-military-to-person::before {
+  content: "\e54c"; }
+
+.fa-file-shield::before {
+  content: "\e4f0"; }
+
+.fa-user-slash::before {
+  content: "\f506"; }
+
+.fa-pen::before {
+  content: "\f304"; }
+
+.fa-tower-observation::before {
+  content: "\e586"; }
+
+.fa-file-code::before {
+  content: "\f1c9"; }
+
+.fa-signal::before {
+  content: "\f012"; }
+
+.fa-signal-5::before {
+  content: "\f012"; }
+
+.fa-signal-perfect::before {
+  content: "\f012"; }
+
+.fa-bus::before {
+  content: "\f207"; }
+
+.fa-heart-circle-xmark::before {
+  content: "\e501"; }
+
+.fa-house-chimney::before {
+  content: "\e3af"; }
+
+.fa-home-lg::before {
+  content: "\e3af"; }
+
+.fa-window-maximize::before {
+  content: "\f2d0"; }
+
+.fa-face-frown::before {
+  content: "\f119"; }
+
+.fa-frown::before {
+  content: "\f119"; }
+
+.fa-prescription::before {
+  content: "\f5b1"; }
+
+.fa-shop::before {
+  content: "\f54f"; }
+
+.fa-store-alt::before {
+  content: "\f54f"; }
+
+.fa-floppy-disk::before {
+  content: "\f0c7"; }
+
+.fa-save::before {
+  content: "\f0c7"; }
+
+.fa-vihara::before {
+  content: "\f6a7"; }
+
+.fa-scale-unbalanced::before {
+  content: "\f515"; }
+
+.fa-balance-scale-left::before {
+  content: "\f515"; }
+
+.fa-sort-up::before {
+  content: "\f0de"; }
+
+.fa-sort-asc::before {
+  content: "\f0de"; }
+
+.fa-comment-dots::before {
+  content: "\f4ad"; }
+
+.fa-commenting::before {
+  content: "\f4ad"; }
+
+.fa-plant-wilt::before {
+  content: "\e5aa"; }
+
+.fa-diamond::before {
+  content: "\f219"; }
+
+.fa-face-grin-squint::before {
+  content: "\f585"; }
+
+.fa-grin-squint::before {
+  content: "\f585"; }
+
+.fa-hand-holding-dollar::before {
+  content: "\f4c0"; }
+
+.fa-hand-holding-usd::before {
+  content: "\f4c0"; }
+
+.fa-bacterium::before {
+  content: "\e05a"; }
+
+.fa-hand-pointer::before {
+  content: "\f25a"; }
+
+.fa-drum-steelpan::before {
+  content: "\f56a"; }
+
+.fa-hand-scissors::before {
+  content: "\f257"; }
+
+.fa-hands-praying::before {
+  content: "\f684"; }
+
+.fa-praying-hands::before {
+  content: "\f684"; }
+
+.fa-arrow-rotate-right::before {
+  content: "\f01e"; }
+
+.fa-arrow-right-rotate::before {
+  content: "\f01e"; }
+
+.fa-arrow-rotate-forward::before {
+  content: "\f01e"; }
+
+.fa-redo::before {
+  content: "\f01e"; }
+
+.fa-biohazard::before {
+  content: "\f780"; }
+
+.fa-location-crosshairs::before {
+  content: "\f601"; }
+
+.fa-location::before {
+  content: "\f601"; }
+
+.fa-mars-double::before {
+  content: "\f227"; }
+
+.fa-child-dress::before {
+  content: "\e59c"; }
+
+.fa-users-between-lines::before {
+  content: "\e591"; }
+
+.fa-lungs-virus::before {
+  content: "\e067"; }
+
+.fa-face-grin-tears::before {
+  content: "\f588"; }
+
+.fa-grin-tears::before {
+  content: "\f588"; }
+
+.fa-phone::before {
+  content: "\f095"; }
+
+.fa-calendar-xmark::before {
+  content: "\f273"; }
+
+.fa-calendar-times::before {
+  content: "\f273"; }
+
+.fa-child-reaching::before {
+  content: "\e59d"; }
+
+.fa-head-side-virus::before {
+  content: "\e064"; }
+
+.fa-user-gear::before {
+  content: "\f4fe"; }
+
+.fa-user-cog::before {
+  content: "\f4fe"; }
+
+.fa-arrow-up-1-9::before {
+  content: "\f163"; }
+
+.fa-sort-numeric-up::before {
+  content: "\f163"; }
+
+.fa-door-closed::before {
+  content: "\f52a"; }
+
+.fa-shield-virus::before {
+  content: "\e06c"; }
+
+.fa-dice-six::before {
+  content: "\f526"; }
+
+.fa-mosquito-net::before {
+  content: "\e52c"; }
+
+.fa-bridge-water::before {
+  content: "\e4ce"; }
+
+.fa-person-booth::before {
+  content: "\f756"; }
+
+.fa-text-width::before {
+  content: "\f035"; }
+
+.fa-hat-wizard::before {
+  content: "\f6e8"; }
+
+.fa-pen-fancy::before {
+  content: "\f5ac"; }
+
+.fa-person-digging::before {
+  content: "\f85e"; }
+
+.fa-digging::before {
+  content: "\f85e"; }
+
+.fa-trash::before {
+  content: "\f1f8"; }
+
+.fa-gauge-simple::before {
+  content: "\f629"; }
+
+.fa-gauge-simple-med::before {
+  content: "\f629"; }
+
+.fa-tachometer-average::before {
+  content: "\f629"; }
+
+.fa-book-medical::before {
+  content: "\f7e6"; }
+
+.fa-poo::before {
+  content: "\f2fe"; }
+
+.fa-quote-right::before {
+  content: "\f10e"; }
+
+.fa-quote-right-alt::before {
+  content: "\f10e"; }
+
+.fa-shirt::before {
+  content: "\f553"; }
+
+.fa-t-shirt::before {
+  content: "\f553"; }
+
+.fa-tshirt::before {
+  content: "\f553"; }
+
+.fa-cubes::before {
+  content: "\f1b3"; }
+
+.fa-divide::before {
+  content: "\f529"; }
+
+.fa-tenge-sign::before {
+  content: "\f7d7"; }
+
+.fa-tenge::before {
+  content: "\f7d7"; }
+
+.fa-headphones::before {
+  content: "\f025"; }
+
+.fa-hands-holding::before {
+  content: "\f4c2"; }
+
+.fa-hands-clapping::before {
+  content: "\e1a8"; }
+
+.fa-republican::before {
+  content: "\f75e"; }
+
+.fa-arrow-left::before {
+  content: "\f060"; }
+
+.fa-person-circle-xmark::before {
+  content: "\e543"; }
+
+.fa-ruler::before {
+  content: "\f545"; }
+
+.fa-align-left::before {
+  content: "\f036"; }
+
+.fa-dice-d6::before {
+  content: "\f6d1"; }
+
+.fa-restroom::before {
+  content: "\f7bd"; }
+
+.fa-j::before {
+  content: "\4a"; }
+
+.fa-users-viewfinder::before {
+  content: "\e595"; }
+
+.fa-file-video::before {
+  content: "\f1c8"; }
+
+.fa-up-right-from-square::before {
+  content: "\f35d"; }
+
+.fa-external-link-alt::before {
+  content: "\f35d"; }
+
+.fa-table-cells::before {
+  content: "\f00a"; }
+
+.fa-th::before {
+  content: "\f00a"; }
+
+.fa-file-pdf::before {
+  content: "\f1c1"; }
+
+.fa-book-bible::before {
+  content: "\f647"; }
+
+.fa-bible::before {
+  content: "\f647"; }
+
+.fa-o::before {
+  content: "\4f"; }
+
+.fa-suitcase-medical::before {
+  content: "\f0fa"; }
+
+.fa-medkit::before {
+  content: "\f0fa"; }
+
+.fa-user-secret::before {
+  content: "\f21b"; }
+
+.fa-otter::before {
+  content: "\f700"; }
+
+.fa-person-dress::before {
+  content: "\f182"; }
+
+.fa-female::before {
+  content: "\f182"; }
+
+.fa-comment-dollar::before {
+  content: "\f651"; }
+
+.fa-business-time::before {
+  content: "\f64a"; }
+
+.fa-briefcase-clock::before {
+  content: "\f64a"; }
+
+.fa-table-cells-large::before {
+  content: "\f009"; }
+
+.fa-th-large::before {
+  content: "\f009"; }
+
+.fa-book-tanakh::before {
+  content: "\f827"; }
+
+.fa-tanakh::before {
+  content: "\f827"; }
+
+.fa-phone-volume::before {
+  content: "\f2a0"; }
+
+.fa-volume-control-phone::before {
+  content: "\f2a0"; }
+
+.fa-hat-cowboy-side::before {
+  content: "\f8c1"; }
+
+.fa-clipboard-user::before {
+  content: "\f7f3"; }
+
+.fa-child::before {
+  content: "\f1ae"; }
+
+.fa-lira-sign::before {
+  content: "\f195"; }
+
+.fa-satellite::before {
+  content: "\f7bf"; }
+
+.fa-plane-lock::before {
+  content: "\e558"; }
+
+.fa-tag::before {
+  content: "\f02b"; }
+
+.fa-comment::before {
+  content: "\f075"; }
+
+.fa-cake-candles::before {
+  content: "\f1fd"; }
+
+.fa-birthday-cake::before {
+  content: "\f1fd"; }
+
+.fa-cake::before {
+  content: "\f1fd"; }
+
+.fa-envelope::before {
+  content: "\f0e0"; }
+
+.fa-angles-up::before {
+  content: "\f102"; }
+
+.fa-angle-double-up::before {
+  content: "\f102"; }
+
+.fa-paperclip::before {
+  content: "\f0c6"; }
+
+.fa-arrow-right-to-city::before {
+  content: "\e4b3"; }
+
+.fa-ribbon::before {
+  content: "\f4d6"; }
+
+.fa-lungs::before {
+  content: "\f604"; }
+
+.fa-arrow-up-9-1::before {
+  content: "\f887"; }
+
+.fa-sort-numeric-up-alt::before {
+  content: "\f887"; }
+
+.fa-litecoin-sign::before {
+  content: "\e1d3"; }
+
+.fa-border-none::before {
+  content: "\f850"; }
+
+.fa-circle-nodes::before {
+  content: "\e4e2"; }
+
+.fa-parachute-box::before {
+  content: "\f4cd"; }
+
+.fa-indent::before {
+  content: "\f03c"; }
+
+.fa-truck-field-un::before {
+  content: "\e58e"; }
+
+.fa-hourglass::before {
+  content: "\f254"; }
+
+.fa-hourglass-empty::before {
+  content: "\f254"; }
+
+.fa-mountain::before {
+  content: "\f6fc"; }
+
+.fa-user-doctor::before {
+  content: "\f0f0"; }
+
+.fa-user-md::before {
+  content: "\f0f0"; }
+
+.fa-circle-info::before {
+  content: "\f05a"; }
+
+.fa-info-circle::before {
+  content: "\f05a"; }
+
+.fa-cloud-meatball::before {
+  content: "\f73b"; }
+
+.fa-camera::before {
+  content: "\f030"; }
+
+.fa-camera-alt::before {
+  content: "\f030"; }
+
+.fa-square-virus::before {
+  content: "\e578"; }
+
+.fa-meteor::before {
+  content: "\f753"; }
+
+.fa-car-on::before {
+  content: "\e4dd"; }
+
+.fa-sleigh::before {
+  content: "\f7cc"; }
+
+.fa-arrow-down-1-9::before {
+  content: "\f162"; }
+
+.fa-sort-numeric-asc::before {
+  content: "\f162"; }
+
+.fa-sort-numeric-down::before {
+  content: "\f162"; }
+
+.fa-hand-holding-droplet::before {
+  content: "\f4c1"; }
+
+.fa-hand-holding-water::before {
+  content: "\f4c1"; }
+
+.fa-water::before {
+  content: "\f773"; }
+
+.fa-calendar-check::before {
+  content: "\f274"; }
+
+.fa-braille::before {
+  content: "\f2a1"; }
+
+.fa-prescription-bottle-medical::before {
+  content: "\f486"; }
+
+.fa-prescription-bottle-alt::before {
+  content: "\f486"; }
+
+.fa-landmark::before {
+  content: "\f66f"; }
+
+.fa-truck::before {
+  content: "\f0d1"; }
+
+.fa-crosshairs::before {
+  content: "\f05b"; }
+
+.fa-person-cane::before {
+  content: "\e53c"; }
+
+.fa-tent::before {
+  content: "\e57d"; }
+
+.fa-vest-patches::before {
+  content: "\e086"; }
+
+.fa-check-double::before {
+  content: "\f560"; }
+
+.fa-arrow-down-a-z::before {
+  content: "\f15d"; }
+
+.fa-sort-alpha-asc::before {
+  content: "\f15d"; }
+
+.fa-sort-alpha-down::before {
+  content: "\f15d"; }
+
+.fa-money-bill-wheat::before {
+  content: "\e52a"; }
+
+.fa-cookie::before {
+  content: "\f563"; }
+
+.fa-arrow-rotate-left::before {
+  content: "\f0e2"; }
+
+.fa-arrow-left-rotate::before {
+  content: "\f0e2"; }
+
+.fa-arrow-rotate-back::before {
+  content: "\f0e2"; }
+
+.fa-arrow-rotate-backward::before {
+  content: "\f0e2"; }
+
+.fa-undo::before {
+  content: "\f0e2"; }
+
+.fa-hard-drive::before {
+  content: "\f0a0"; }
+
+.fa-hdd::before {
+  content: "\f0a0"; }
+
+.fa-face-grin-squint-tears::before {
+  content: "\f586"; }
+
+.fa-grin-squint-tears::before {
+  content: "\f586"; }
+
+.fa-dumbbell::before {
+  content: "\f44b"; }
+
+.fa-rectangle-list::before {
+  content: "\f022"; }
+
+.fa-list-alt::before {
+  content: "\f022"; }
+
+.fa-tarp-droplet::before {
+  content: "\e57c"; }
+
+.fa-house-medical-circle-check::before {
+  content: "\e511"; }
+
+.fa-person-skiing-nordic::before {
+  content: "\f7ca"; }
+
+.fa-skiing-nordic::before {
+  content: "\f7ca"; }
+
+.fa-calendar-plus::before {
+  content: "\f271"; }
+
+.fa-plane-arrival::before {
+  content: "\f5af"; }
+
+.fa-circle-left::before {
+  content: "\f359"; }
+
+.fa-arrow-alt-circle-left::before {
+  content: "\f359"; }
+
+.fa-train-subway::before {
+  content: "\f239"; }
+
+.fa-subway::before {
+  content: "\f239"; }
+
+.fa-chart-gantt::before {
+  content: "\e0e4"; }
+
+.fa-indian-rupee-sign::before {
+  content: "\e1bc"; }
+
+.fa-indian-rupee::before {
+  content: "\e1bc"; }
+
+.fa-inr::before {
+  content: "\e1bc"; }
+
+.fa-crop-simple::before {
+  content: "\f565"; }
+
+.fa-crop-alt::before {
+  content: "\f565"; }
+
+.fa-money-bill-1::before {
+  content: "\f3d1"; }
+
+.fa-money-bill-alt::before {
+  content: "\f3d1"; }
+
+.fa-left-long::before {
+  content: "\f30a"; }
+
+.fa-long-arrow-alt-left::before {
+  content: "\f30a"; }
+
+.fa-dna::before {
+  content: "\f471"; }
+
+.fa-virus-slash::before {
+  content: "\e075"; }
+
+.fa-minus::before {
+  content: "\f068"; }
+
+.fa-subtract::before {
+  content: "\f068"; }
+
+.fa-chess::before {
+  content: "\f439"; }
+
+.fa-arrow-left-long::before {
+  content: "\f177"; }
+
+.fa-long-arrow-left::before {
+  content: "\f177"; }
+
+.fa-plug-circle-check::before {
+  content: "\e55c"; }
+
+.fa-street-view::before {
+  content: "\f21d"; }
+
+.fa-franc-sign::before {
+  content: "\e18f"; }
+
+.fa-volume-off::before {
+  content: "\f026"; }
+
+.fa-hands-asl-interpreting::before {
+  content: "\f2a3"; }
+
+.fa-american-sign-language-interpreting::before {
+  content: "\f2a3"; }
+
+.fa-asl-interpreting::before {
+  content: "\f2a3"; }
+
+.fa-hands-american-sign-language-interpreting::before {
+  content: "\f2a3"; }
+
+.fa-gear::before {
+  content: "\f013"; }
+
+.fa-cog::before {
+  content: "\f013"; }
+
+.fa-droplet-slash::before {
+  content: "\f5c7"; }
+
+.fa-tint-slash::before {
+  content: "\f5c7"; }
+
+.fa-mosque::before {
+  content: "\f678"; }
+
+.fa-mosquito::before {
+  content: "\e52b"; }
+
+.fa-star-of-david::before {
+  content: "\f69a"; }
+
+.fa-person-military-rifle::before {
+  content: "\e54b"; }
+
+.fa-cart-shopping::before {
+  content: "\f07a"; }
+
+.fa-shopping-cart::before {
+  content: "\f07a"; }
+
+.fa-vials::before {
+  content: "\f493"; }
+
+.fa-plug-circle-plus::before {
+  content: "\e55f"; }
+
+.fa-place-of-worship::before {
+  content: "\f67f"; }
+
+.fa-grip-vertical::before {
+  content: "\f58e"; }
+
+.fa-arrow-turn-up::before {
+  content: "\f148"; }
+
+.fa-level-up::before {
+  content: "\f148"; }
+
+.fa-u::before {
+  content: "\55"; }
+
+.fa-square-root-variable::before {
+  content: "\f698"; }
+
+.fa-square-root-alt::before {
+  content: "\f698"; }
+
+.fa-clock::before {
+  content: "\f017"; }
+
+.fa-clock-four::before {
+  content: "\f017"; }
+
+.fa-backward-step::before {
+  content: "\f048"; }
+
+.fa-step-backward::before {
+  content: "\f048"; }
+
+.fa-pallet::before {
+  content: "\f482"; }
+
+.fa-faucet::before {
+  content: "\e005"; }
+
+.fa-baseball-bat-ball::before {
+  content: "\f432"; }
+
+.fa-s::before {
+  content: "\53"; }
+
+.fa-timeline::before {
+  content: "\e29c"; }
+
+.fa-keyboard::before {
+  content: "\f11c"; }
+
+.fa-caret-down::before {
+  content: "\f0d7"; }
+
+.fa-house-chimney-medical::before {
+  content: "\f7f2"; }
+
+.fa-clinic-medical::before {
+  content: "\f7f2"; }
+
+.fa-temperature-three-quarters::before {
+  content: "\f2c8"; }
+
+.fa-temperature-3::before {
+  content: "\f2c8"; }
+
+.fa-thermometer-3::before {
+  content: "\f2c8"; }
+
+.fa-thermometer-three-quarters::before {
+  content: "\f2c8"; }
+
+.fa-mobile-screen::before {
+  content: "\f3cf"; }
+
+.fa-mobile-android-alt::before {
+  content: "\f3cf"; }
+
+.fa-plane-up::before {
+  content: "\e22d"; }
+
+.fa-piggy-bank::before {
+  content: "\f4d3"; }
+
+.fa-battery-half::before {
+  content: "\f242"; }
+
+.fa-battery-3::before {
+  content: "\f242"; }
+
+.fa-mountain-city::before {
+  content: "\e52e"; }
+
+.fa-coins::before {
+  content: "\f51e"; }
+
+.fa-khanda::before {
+  content: "\f66d"; }
+
+.fa-sliders::before {
+  content: "\f1de"; }
+
+.fa-sliders-h::before {
+  content: "\f1de"; }
+
+.fa-folder-tree::before {
+  content: "\f802"; }
+
+.fa-network-wired::before {
+  content: "\f6ff"; }
+
+.fa-map-pin::before {
+  content: "\f276"; }
+
+.fa-hamsa::before {
+  content: "\f665"; }
+
+.fa-cent-sign::before {
+  content: "\e3f5"; }
+
+.fa-flask::before {
+  content: "\f0c3"; }
+
+.fa-person-pregnant::before {
+  content: "\e31e"; }
+
+.fa-wand-sparkles::before {
+  content: "\f72b"; }
+
+.fa-ellipsis-vertical::before {
+  content: "\f142"; }
+
+.fa-ellipsis-v::before {
+  content: "\f142"; }
+
+.fa-ticket::before {
+  content: "\f145"; }
+
+.fa-power-off::before {
+  content: "\f011"; }
+
+.fa-right-long::before {
+  content: "\f30b"; }
+
+.fa-long-arrow-alt-right::before {
+  content: "\f30b"; }
+
+.fa-flag-usa::before {
+  content: "\f74d"; }
+
+.fa-laptop-file::before {
+  content: "\e51d"; }
+
+.fa-tty::before {
+  content: "\f1e4"; }
+
+.fa-teletype::before {
+  content: "\f1e4"; }
+
+.fa-diagram-next::before {
+  content: "\e476"; }
+
+.fa-person-rifle::before {
+  content: "\e54e"; }
+
+.fa-house-medical-circle-exclamation::before {
+  content: "\e512"; }
+
+.fa-closed-captioning::before {
+  content: "\f20a"; }
+
+.fa-person-hiking::before {
+  content: "\f6ec"; }
+
+.fa-hiking::before {
+  content: "\f6ec"; }
+
+.fa-venus-double::before {
+  content: "\f226"; }
+
+.fa-images::before {
+  content: "\f302"; }
+
+.fa-calculator::before {
+  content: "\f1ec"; }
+
+.fa-people-pulling::before {
+  content: "\e535"; }
+
+.fa-n::before {
+  content: "\4e"; }
+
+.fa-cable-car::before {
+  content: "\f7da"; }
+
+.fa-tram::before {
+  content: "\f7da"; }
+
+.fa-cloud-rain::before {
+  content: "\f73d"; }
+
+.fa-building-circle-xmark::before {
+  content: "\e4d4"; }
+
+.fa-ship::before {
+  content: "\f21a"; }
+
+.fa-arrows-down-to-line::before {
+  content: "\e4b8"; }
+
+.fa-download::before {
+  content: "\f019"; }
+
+.fa-face-grin::before {
+  content: "\f580"; }
+
+.fa-grin::before {
+  content: "\f580"; }
+
+.fa-delete-left::before {
+  content: "\f55a"; }
+
+.fa-backspace::before {
+  content: "\f55a"; }
+
+.fa-eye-dropper::before {
+  content: "\f1fb"; }
+
+.fa-eye-dropper-empty::before {
+  content: "\f1fb"; }
+
+.fa-eyedropper::before {
+  content: "\f1fb"; }
+
+.fa-file-circle-check::before {
+  content: "\e5a0"; }
+
+.fa-forward::before {
+  content: "\f04e"; }
+
+.fa-mobile::before {
+  content: "\f3ce"; }
+
+.fa-mobile-android::before {
+  content: "\f3ce"; }
+
+.fa-mobile-phone::before {
+  content: "\f3ce"; }
+
+.fa-face-meh::before {
+  content: "\f11a"; }
+
+.fa-meh::before {
+  content: "\f11a"; }
+
+.fa-align-center::before {
+  content: "\f037"; }
+
+.fa-book-skull::before {
+  content: "\f6b7"; }
+
+.fa-book-dead::before {
+  content: "\f6b7"; }
+
+.fa-id-card::before {
+  content: "\f2c2"; }
+
+.fa-drivers-license::before {
+  content: "\f2c2"; }
+
+.fa-outdent::before {
+  content: "\f03b"; }
+
+.fa-dedent::before {
+  content: "\f03b"; }
+
+.fa-heart-circle-exclamation::before {
+  content: "\e4fe"; }
+
+.fa-house::before {
+  content: "\f015"; }
+
+.fa-home::before {
+  content: "\f015"; }
+
+.fa-home-alt::before {
+  content: "\f015"; }
+
+.fa-home-lg-alt::before {
+  content: "\f015"; }
+
+.fa-calendar-week::before {
+  content: "\f784"; }
+
+.fa-laptop-medical::before {
+  content: "\f812"; }
+
+.fa-b::before {
+  content: "\42"; }
+
+.fa-file-medical::before {
+  content: "\f477"; }
+
+.fa-dice-one::before {
+  content: "\f525"; }
+
+.fa-kiwi-bird::before {
+  content: "\f535"; }
+
+.fa-arrow-right-arrow-left::before {
+  content: "\f0ec"; }
+
+.fa-exchange::before {
+  content: "\f0ec"; }
+
+.fa-rotate-right::before {
+  content: "\f2f9"; }
+
+.fa-redo-alt::before {
+  content: "\f2f9"; }
+
+.fa-rotate-forward::before {
+  content: "\f2f9"; }
+
+.fa-utensils::before {
+  content: "\f2e7"; }
+
+.fa-cutlery::before {
+  content: "\f2e7"; }
+
+.fa-arrow-up-wide-short::before {
+  content: "\f161"; }
+
+.fa-sort-amount-up::before {
+  content: "\f161"; }
+
+.fa-mill-sign::before {
+  content: "\e1ed"; }
+
+.fa-bowl-rice::before {
+  content: "\e2eb"; }
+
+.fa-skull::before {
+  content: "\f54c"; }
+
+.fa-tower-broadcast::before {
+  content: "\f519"; }
+
+.fa-broadcast-tower::before {
+  content: "\f519"; }
+
+.fa-truck-pickup::before {
+  content: "\f63c"; }
+
+.fa-up-long::before {
+  content: "\f30c"; }
+
+.fa-long-arrow-alt-up::before {
+  content: "\f30c"; }
+
+.fa-stop::before {
+  content: "\f04d"; }
+
+.fa-code-merge::before {
+  content: "\f387"; }
+
+.fa-upload::before {
+  content: "\f093"; }
+
+.fa-hurricane::before {
+  content: "\f751"; }
+
+.fa-mound::before {
+  content: "\e52d"; }
+
+.fa-toilet-portable::before {
+  content: "\e583"; }
+
+.fa-compact-disc::before {
+  content: "\f51f"; }
+
+.fa-file-arrow-down::before {
+  content: "\f56d"; }
+
+.fa-file-download::before {
+  content: "\f56d"; }
+
+.fa-caravan::before {
+  content: "\f8ff"; }
+
+.fa-shield-cat::before {
+  content: "\e572"; }
+
+.fa-bolt::before {
+  content: "\f0e7"; }
+
+.fa-zap::before {
+  content: "\f0e7"; }
+
+.fa-glass-water::before {
+  content: "\e4f4"; }
+
+.fa-oil-well::before {
+  content: "\e532"; }
+
+.fa-vault::before {
+  content: "\e2c5"; }
+
+.fa-mars::before {
+  content: "\f222"; }
+
+.fa-toilet::before {
+  content: "\f7d8"; }
+
+.fa-plane-circle-xmark::before {
+  content: "\e557"; }
+
+.fa-yen-sign::before {
+  content: "\f157"; }
+
+.fa-cny::before {
+  content: "\f157"; }
+
+.fa-jpy::before {
+  content: "\f157"; }
+
+.fa-rmb::before {
+  content: "\f157"; }
+
+.fa-yen::before {
+  content: "\f157"; }
+
+.fa-ruble-sign::before {
+  content: "\f158"; }
+
+.fa-rouble::before {
+  content: "\f158"; }
+
+.fa-rub::before {
+  content: "\f158"; }
+
+.fa-ruble::before {
+  content: "\f158"; }
+
+.fa-sun::before {
+  content: "\f185"; }
+
+.fa-guitar::before {
+  content: "\f7a6"; }
+
+.fa-face-laugh-wink::before {
+  content: "\f59c"; }
+
+.fa-laugh-wink::before {
+  content: "\f59c"; }
+
+.fa-horse-head::before {
+  content: "\f7ab"; }
+
+.fa-bore-hole::before {
+  content: "\e4c3"; }
+
+.fa-industry::before {
+  content: "\f275"; }
+
+.fa-circle-down::before {
+  content: "\f358"; }
+
+.fa-arrow-alt-circle-down::before {
+  content: "\f358"; }
+
+.fa-arrows-turn-to-dots::before {
+  content: "\e4c1"; }
+
+.fa-florin-sign::before {
+  content: "\e184"; }
+
+.fa-arrow-down-short-wide::before {
+  content: "\f884"; }
+
+.fa-sort-amount-desc::before {
+  content: "\f884"; }
+
+.fa-sort-amount-down-alt::before {
+  content: "\f884"; }
+
+.fa-less-than::before {
+  content: "\3c"; }
+
+.fa-angle-down::before {
+  content: "\f107"; }
+
+.fa-car-tunnel::before {
+  content: "\e4de"; }
+
+.fa-head-side-cough::before {
+  content: "\e061"; }
+
+.fa-grip-lines::before {
+  content: "\f7a4"; }
+
+.fa-thumbs-down::before {
+  content: "\f165"; }
+
+.fa-user-lock::before {
+  content: "\f502"; }
+
+.fa-arrow-right-long::before {
+  content: "\f178"; }
+
+.fa-long-arrow-right::before {
+  content: "\f178"; }
+
+.fa-anchor-circle-xmark::before {
+  content: "\e4ac"; }
+
+.fa-ellipsis::before {
+  content: "\f141"; }
+
+.fa-ellipsis-h::before {
+  content: "\f141"; }
+
+.fa-chess-pawn::before {
+  content: "\f443"; }
+
+.fa-kit-medical::before {
+  content: "\f479"; }
+
+.fa-first-aid::before {
+  content: "\f479"; }
+
+.fa-person-through-window::before {
+  content: "\e5a9"; }
+
+.fa-toolbox::before {
+  content: "\f552"; }
+
+.fa-hands-holding-circle::before {
+  content: "\e4fb"; }
+
+.fa-bug::before {
+  content: "\f188"; }
+
+.fa-credit-card::before {
+  content: "\f09d"; }
+
+.fa-credit-card-alt::before {
+  content: "\f09d"; }
+
+.fa-car::before {
+  content: "\f1b9"; }
+
+.fa-automobile::before {
+  content: "\f1b9"; }
+
+.fa-hand-holding-hand::before {
+  content: "\e4f7"; }
+
+.fa-book-open-reader::before {
+  content: "\f5da"; }
+
+.fa-book-reader::before {
+  content: "\f5da"; }
+
+.fa-mountain-sun::before {
+  content: "\e52f"; }
+
+.fa-arrows-left-right-to-line::before {
+  content: "\e4ba"; }
+
+.fa-dice-d20::before {
+  content: "\f6cf"; }
+
+.fa-truck-droplet::before {
+  content: "\e58c"; }
+
+.fa-file-circle-xmark::before {
+  content: "\e5a1"; }
+
+.fa-temperature-arrow-up::before {
+  content: "\e040"; }
+
+.fa-temperature-up::before {
+  content: "\e040"; }
+
+.fa-medal::before {
+  content: "\f5a2"; }
+
+.fa-bed::before {
+  content: "\f236"; }
+
+.fa-square-h::before {
+  content: "\f0fd"; }
+
+.fa-h-square::before {
+  content: "\f0fd"; }
+
+.fa-podcast::before {
+  content: "\f2ce"; }
+
+.fa-temperature-full::before {
+  content: "\f2c7"; }
+
+.fa-temperature-4::before {
+  content: "\f2c7"; }
+
+.fa-thermometer-4::before {
+  content: "\f2c7"; }
+
+.fa-thermometer-full::before {
+  content: "\f2c7"; }
+
+.fa-bell::before {
+  content: "\f0f3"; }
+
+.fa-superscript::before {
+  content: "\f12b"; }
+
+.fa-plug-circle-xmark::before {
+  content: "\e560"; }
+
+.fa-star-of-life::before {
+  content: "\f621"; }
+
+.fa-phone-slash::before {
+  content: "\f3dd"; }
+
+.fa-paint-roller::before {
+  content: "\f5aa"; }
+
+.fa-handshake-angle::before {
+  content: "\f4c4"; }
+
+.fa-hands-helping::before {
+  content: "\f4c4"; }
+
+.fa-location-dot::before {
+  content: "\f3c5"; }
+
+.fa-map-marker-alt::before {
+  content: "\f3c5"; }
+
+.fa-file::before {
+  content: "\f15b"; }
+
+.fa-greater-than::before {
+  content: "\3e"; }
+
+.fa-person-swimming::before {
+  content: "\f5c4"; }
+
+.fa-swimmer::before {
+  content: "\f5c4"; }
+
+.fa-arrow-down::before {
+  content: "\f063"; }
+
+.fa-droplet::before {
+  content: "\f043"; }
+
+.fa-tint::before {
+  content: "\f043"; }
+
+.fa-eraser::before {
+  content: "\f12d"; }
+
+.fa-earth-americas::before {
+  content: "\f57d"; }
+
+.fa-earth::before {
+  content: "\f57d"; }
+
+.fa-earth-america::before {
+  content: "\f57d"; }
+
+.fa-globe-americas::before {
+  content: "\f57d"; }
+
+.fa-person-burst::before {
+  content: "\e53b"; }
+
+.fa-dove::before {
+  content: "\f4ba"; }
+
+.fa-battery-empty::before {
+  content: "\f244"; }
+
+.fa-battery-0::before {
+  content: "\f244"; }
+
+.fa-socks::before {
+  content: "\f696"; }
+
+.fa-inbox::before {
+  content: "\f01c"; }
+
+.fa-section::before {
+  content: "\e447"; }
+
+.fa-gauge-high::before {
+  content: "\f625"; }
+
+.fa-tachometer-alt::before {
+  content: "\f625"; }
+
+.fa-tachometer-alt-fast::before {
+  content: "\f625"; }
+
+.fa-envelope-open-text::before {
+  content: "\f658"; }
+
+.fa-hospital::before {
+  content: "\f0f8"; }
+
+.fa-hospital-alt::before {
+  content: "\f0f8"; }
+
+.fa-hospital-wide::before {
+  content: "\f0f8"; }
+
+.fa-wine-bottle::before {
+  content: "\f72f"; }
+
+.fa-chess-rook::before {
+  content: "\f447"; }
+
+.fa-bars-staggered::before {
+  content: "\f550"; }
+
+.fa-reorder::before {
+  content: "\f550"; }
+
+.fa-stream::before {
+  content: "\f550"; }
+
+.fa-dharmachakra::before {
+  content: "\f655"; }
+
+.fa-hotdog::before {
+  content: "\f80f"; }
+
+.fa-person-walking-with-cane::before {
+  content: "\f29d"; }
+
+.fa-blind::before {
+  content: "\f29d"; }
+
+.fa-drum::before {
+  content: "\f569"; }
+
+.fa-ice-cream::before {
+  content: "\f810"; }
+
+.fa-heart-circle-bolt::before {
+  content: "\e4fc"; }
+
+.fa-fax::before {
+  content: "\f1ac"; }
+
+.fa-paragraph::before {
+  content: "\f1dd"; }
+
+.fa-check-to-slot::before {
+  content: "\f772"; }
+
+.fa-vote-yea::before {
+  content: "\f772"; }
+
+.fa-star-half::before {
+  content: "\f089"; }
+
+.fa-boxes-stacked::before {
+  content: "\f468"; }
+
+.fa-boxes::before {
+  content: "\f468"; }
+
+.fa-boxes-alt::before {
+  content: "\f468"; }
+
+.fa-link::before {
+  content: "\f0c1"; }
+
+.fa-chain::before {
+  content: "\f0c1"; }
+
+.fa-ear-listen::before {
+  content: "\f2a2"; }
+
+.fa-assistive-listening-systems::before {
+  content: "\f2a2"; }
+
+.fa-tree-city::before {
+  content: "\e587"; }
+
+.fa-play::before {
+  content: "\f04b"; }
+
+.fa-font::before {
+  content: "\f031"; }
+
+.fa-rupiah-sign::before {
+  content: "\e23d"; }
+
+.fa-magnifying-glass::before {
+  content: "\f002"; }
+
+.fa-search::before {
+  content: "\f002"; }
+
+.fa-table-tennis-paddle-ball::before {
+  content: "\f45d"; }
+
+.fa-ping-pong-paddle-ball::before {
+  content: "\f45d"; }
+
+.fa-table-tennis::before {
+  content: "\f45d"; }
+
+.fa-person-dots-from-line::before {
+  content: "\f470"; }
+
+.fa-diagnoses::before {
+  content: "\f470"; }
+
+.fa-trash-can-arrow-up::before {
+  content: "\f82a"; }
+
+.fa-trash-restore-alt::before {
+  content: "\f82a"; }
+
+.fa-naira-sign::before {
+  content: "\e1f6"; }
+
+.fa-cart-arrow-down::before {
+  content: "\f218"; }
+
+.fa-walkie-talkie::before {
+  content: "\f8ef"; }
+
+.fa-file-pen::before {
+  content: "\f31c"; }
+
+.fa-file-edit::before {
+  content: "\f31c"; }
+
+.fa-receipt::before {
+  content: "\f543"; }
+
+.fa-square-pen::before {
+  content: "\f14b"; }
+
+.fa-pen-square::before {
+  content: "\f14b"; }
+
+.fa-pencil-square::before {
+  content: "\f14b"; }
+
+.fa-suitcase-rolling::before {
+  content: "\f5c1"; }
+
+.fa-person-circle-exclamation::before {
+  content: "\e53f"; }
+
+.fa-chevron-down::before {
+  content: "\f078"; }
+
+.fa-battery-full::before {
+  content: "\f240"; }
+
+.fa-battery::before {
+  content: "\f240"; }
+
+.fa-battery-5::before {
+  content: "\f240"; }
+
+.fa-skull-crossbones::before {
+  content: "\f714"; }
+
+.fa-code-compare::before {
+  content: "\e13a"; }
+
+.fa-list-ul::before {
+  content: "\f0ca"; }
+
+.fa-list-dots::before {
+  content: "\f0ca"; }
+
+.fa-school-lock::before {
+  content: "\e56f"; }
+
+.fa-tower-cell::before {
+  content: "\e585"; }
+
+.fa-down-long::before {
+  content: "\f309"; }
+
+.fa-long-arrow-alt-down::before {
+  content: "\f309"; }
+
+.fa-ranking-star::before {
+  content: "\e561"; }
+
+.fa-chess-king::before {
+  content: "\f43f"; }
+
+.fa-person-harassing::before {
+  content: "\e549"; }
+
+.fa-brazilian-real-sign::before {
+  content: "\e46c"; }
+
+.fa-landmark-dome::before {
+  content: "\f752"; }
+
+.fa-landmark-alt::before {
+  content: "\f752"; }
+
+.fa-arrow-up::before {
+  content: "\f062"; }
+
+.fa-tv::before {
+  content: "\f26c"; }
+
+.fa-television::before {
+  content: "\f26c"; }
+
+.fa-tv-alt::before {
+  content: "\f26c"; }
+
+.fa-shrimp::before {
+  content: "\e448"; }
+
+.fa-list-check::before {
+  content: "\f0ae"; }
+
+.fa-tasks::before {
+  content: "\f0ae"; }
+
+.fa-jug-detergent::before {
+  content: "\e519"; }
+
+.fa-circle-user::before {
+  content: "\f2bd"; }
+
+.fa-user-circle::before {
+  content: "\f2bd"; }
+
+.fa-user-shield::before {
+  content: "\f505"; }
+
+.fa-wind::before {
+  content: "\f72e"; }
+
+.fa-car-burst::before {
+  content: "\f5e1"; }
+
+.fa-car-crash::before {
+  content: "\f5e1"; }
+
+.fa-y::before {
+  content: "\59"; }
+
+.fa-person-snowboarding::before {
+  content: "\f7ce"; }
+
+.fa-snowboarding::before {
+  content: "\f7ce"; }
+
+.fa-truck-fast::before {
+  content: "\f48b"; }
+
+.fa-shipping-fast::before {
+  content: "\f48b"; }
+
+.fa-fish::before {
+  content: "\f578"; }
+
+.fa-user-graduate::before {
+  content: "\f501"; }
+
+.fa-circle-half-stroke::before {
+  content: "\f042"; }
+
+.fa-adjust::before {
+  content: "\f042"; }
+
+.fa-clapperboard::before {
+  content: "\e131"; }
+
+.fa-circle-radiation::before {
+  content: "\f7ba"; }
+
+.fa-radiation-alt::before {
+  content: "\f7ba"; }
+
+.fa-baseball::before {
+  content: "\f433"; }
+
+.fa-baseball-ball::before {
+  content: "\f433"; }
+
+.fa-jet-fighter-up::before {
+  content: "\e518"; }
+
+.fa-diagram-project::before {
+  content: "\f542"; }
+
+.fa-project-diagram::before {
+  content: "\f542"; }
+
+.fa-copy::before {
+  content: "\f0c5"; }
+
+.fa-volume-xmark::before {
+  content: "\f6a9"; }
+
+.fa-volume-mute::before {
+  content: "\f6a9"; }
+
+.fa-volume-times::before {
+  content: "\f6a9"; }
+
+.fa-hand-sparkles::before {
+  content: "\e05d"; }
+
+.fa-grip::before {
+  content: "\f58d"; }
+
+.fa-grip-horizontal::before {
+  content: "\f58d"; }
+
+.fa-share-from-square::before {
+  content: "\f14d"; }
+
+.fa-share-square::before {
+  content: "\f14d"; }
+
+.fa-child-combatant::before {
+  content: "\e4e0"; }
+
+.fa-child-rifle::before {
+  content: "\e4e0"; }
+
+.fa-gun::before {
+  content: "\e19b"; }
+
+.fa-square-phone::before {
+  content: "\f098"; }
+
+.fa-phone-square::before {
+  content: "\f098"; }
+
+.fa-plus::before {
+  content: "\2b"; }
+
+.fa-add::before {
+  content: "\2b"; }
+
+.fa-expand::before {
+  content: "\f065"; }
+
+.fa-computer::before {
+  content: "\e4e5"; }
+
+.fa-xmark::before {
+  content: "\f00d"; }
+
+.fa-close::before {
+  content: "\f00d"; }
+
+.fa-multiply::before {
+  content: "\f00d"; }
+
+.fa-remove::before {
+  content: "\f00d"; }
+
+.fa-times::before {
+  content: "\f00d"; }
+
+.fa-arrows-up-down-left-right::before {
+  content: "\f047"; }
+
+.fa-arrows::before {
+  content: "\f047"; }
+
+.fa-chalkboard-user::before {
+  content: "\f51c"; }
+
+.fa-chalkboard-teacher::before {
+  content: "\f51c"; }
+
+.fa-peso-sign::before {
+  content: "\e222"; }
+
+.fa-building-shield::before {
+  content: "\e4d8"; }
+
+.fa-baby::before {
+  content: "\f77c"; }
+
+.fa-users-line::before {
+  content: "\e592"; }
+
+.fa-quote-left::before {
+  content: "\f10d"; }
+
+.fa-quote-left-alt::before {
+  content: "\f10d"; }
+
+.fa-tractor::before {
+  content: "\f722"; }
+
+.fa-trash-arrow-up::before {
+  content: "\f829"; }
+
+.fa-trash-restore::before {
+  content: "\f829"; }
+
+.fa-arrow-down-up-lock::before {
+  content: "\e4b0"; }
+
+.fa-lines-leaning::before {
+  content: "\e51e"; }
+
+.fa-ruler-combined::before {
+  content: "\f546"; }
+
+.fa-copyright::before {
+  content: "\f1f9"; }
+
+.fa-equals::before {
+  content: "\3d"; }
+
+.fa-blender::before {
+  content: "\f517"; }
+
+.fa-teeth::before {
+  content: "\f62e"; }
+
+.fa-shekel-sign::before {
+  content: "\f20b"; }
+
+.fa-ils::before {
+  content: "\f20b"; }
+
+.fa-shekel::before {
+  content: "\f20b"; }
+
+.fa-sheqel::before {
+  content: "\f20b"; }
+
+.fa-sheqel-sign::before {
+  content: "\f20b"; }
+
+.fa-map::before {
+  content: "\f279"; }
+
+.fa-rocket::before {
+  content: "\f135"; }
+
+.fa-photo-film::before {
+  content: "\f87c"; }
+
+.fa-photo-video::before {
+  content: "\f87c"; }
+
+.fa-folder-minus::before {
+  content: "\f65d"; }
+
+.fa-store::before {
+  content: "\f54e"; }
+
+.fa-arrow-trend-up::before {
+  content: "\e098"; }
+
+.fa-plug-circle-minus::before {
+  content: "\e55e"; }
+
+.fa-sign-hanging::before {
+  content: "\f4d9"; }
+
+.fa-sign::before {
+  content: "\f4d9"; }
+
+.fa-bezier-curve::before {
+  content: "\f55b"; }
+
+.fa-bell-slash::before {
+  content: "\f1f6"; }
+
+.fa-tablet::before {
+  content: "\f3fb"; }
+
+.fa-tablet-android::before {
+  content: "\f3fb"; }
+
+.fa-school-flag::before {
+  content: "\e56e"; }
+
+.fa-fill::before {
+  content: "\f575"; }
+
+.fa-angle-up::before {
+  content: "\f106"; }
+
+.fa-drumstick-bite::before {
+  content: "\f6d7"; }
+
+.fa-holly-berry::before {
+  content: "\f7aa"; }
+
+.fa-chevron-left::before {
+  content: "\f053"; }
+
+.fa-bacteria::before {
+  content: "\e059"; }
+
+.fa-hand-lizard::before {
+  content: "\f258"; }
+
+.fa-notdef::before {
+  content: "\e1fe"; }
+
+.fa-disease::before {
+  content: "\f7fa"; }
+
+.fa-briefcase-medical::before {
+  content: "\f469"; }
+
+.fa-genderless::before {
+  content: "\f22d"; }
+
+.fa-chevron-right::before {
+  content: "\f054"; }
+
+.fa-retweet::before {
+  content: "\f079"; }
+
+.fa-car-rear::before {
+  content: "\f5de"; }
+
+.fa-car-alt::before {
+  content: "\f5de"; }
+
+.fa-pump-soap::before {
+  content: "\e06b"; }
+
+.fa-video-slash::before {
+  content: "\f4e2"; }
+
+.fa-battery-quarter::before {
+  content: "\f243"; }
+
+.fa-battery-2::before {
+  content: "\f243"; }
+
+.fa-radio::before {
+  content: "\f8d7"; }
+
+.fa-baby-carriage::before {
+  content: "\f77d"; }
+
+.fa-carriage-baby::before {
+  content: "\f77d"; }
+
+.fa-traffic-light::before {
+  content: "\f637"; }
+
+.fa-thermometer::before {
+  content: "\f491"; }
+
+.fa-vr-cardboard::before {
+  content: "\f729"; }
+
+.fa-hand-middle-finger::before {
+  content: "\f806"; }
+
+.fa-percent::before {
+  content: "\25"; }
+
+.fa-percentage::before {
+  content: "\25"; }
+
+.fa-truck-moving::before {
+  content: "\f4df"; }
+
+.fa-glass-water-droplet::before {
+  content: "\e4f5"; }
+
+.fa-display::before {
+  content: "\e163"; }
+
+.fa-face-smile::before {
+  content: "\f118"; }
+
+.fa-smile::before {
+  content: "\f118"; }
+
+.fa-thumbtack::before {
+  content: "\f08d"; }
+
+.fa-thumb-tack::before {
+  content: "\f08d"; }
+
+.fa-trophy::before {
+  content: "\f091"; }
+
+.fa-person-praying::before {
+  content: "\f683"; }
+
+.fa-pray::before {
+  content: "\f683"; }
+
+.fa-hammer::before {
+  content: "\f6e3"; }
+
+.fa-hand-peace::before {
+  content: "\f25b"; }
+
+.fa-rotate::before {
+  content: "\f2f1"; }
+
+.fa-sync-alt::before {
+  content: "\f2f1"; }
+
+.fa-spinner::before {
+  content: "\f110"; }
+
+.fa-robot::before {
+  content: "\f544"; }
+
+.fa-peace::before {
+  content: "\f67c"; }
+
+.fa-gears::before {
+  content: "\f085"; }
+
+.fa-cogs::before {
+  content: "\f085"; }
+
+.fa-warehouse::before {
+  content: "\f494"; }
+
+.fa-arrow-up-right-dots::before {
+  content: "\e4b7"; }
+
+.fa-splotch::before {
+  content: "\f5bc"; }
+
+.fa-face-grin-hearts::before {
+  content: "\f584"; }
+
+.fa-grin-hearts::before {
+  content: "\f584"; }
+
+.fa-dice-four::before {
+  content: "\f524"; }
+
+.fa-sim-card::before {
+  content: "\f7c4"; }
+
+.fa-transgender::before {
+  content: "\f225"; }
+
+.fa-transgender-alt::before {
+  content: "\f225"; }
+
+.fa-mercury::before {
+  content: "\f223"; }
+
+.fa-arrow-turn-down::before {
+  content: "\f149"; }
+
+.fa-level-down::before {
+  content: "\f149"; }
+
+.fa-person-falling-burst::before {
+  content: "\e547"; }
+
+.fa-award::before {
+  content: "\f559"; }
+
+.fa-ticket-simple::before {
+  content: "\f3ff"; }
+
+.fa-ticket-alt::before {
+  content: "\f3ff"; }
+
+.fa-building::before {
+  content: "\f1ad"; }
+
+.fa-angles-left::before {
+  content: "\f100"; }
+
+.fa-angle-double-left::before {
+  content: "\f100"; }
+
+.fa-qrcode::before {
+  content: "\f029"; }
+
+.fa-clock-rotate-left::before {
+  content: "\f1da"; }
+
+.fa-history::before {
+  content: "\f1da"; }
+
+.fa-face-grin-beam-sweat::before {
+  content: "\f583"; }
+
+.fa-grin-beam-sweat::before {
+  content: "\f583"; }
+
+.fa-file-export::before {
+  content: "\f56e"; }
+
+.fa-arrow-right-from-file::before {
+  content: "\f56e"; }
+
+.fa-shield::before {
+  content: "\f132"; }
+
+.fa-shield-blank::before {
+  content: "\f132"; }
+
+.fa-arrow-up-short-wide::before {
+  content: "\f885"; }
+
+.fa-sort-amount-up-alt::before {
+  content: "\f885"; }
+
+.fa-house-medical::before {
+  content: "\e3b2"; }
+
+.fa-golf-ball-tee::before {
+  content: "\f450"; }
+
+.fa-golf-ball::before {
+  content: "\f450"; }
+
+.fa-circle-chevron-left::before {
+  content: "\f137"; }
+
+.fa-chevron-circle-left::before {
+  content: "\f137"; }
+
+.fa-house-chimney-window::before {
+  content: "\e00d"; }
+
+.fa-pen-nib::before {
+  content: "\f5ad"; }
+
+.fa-tent-arrow-turn-left::before {
+  content: "\e580"; }
+
+.fa-tents::before {
+  content: "\e582"; }
+
+.fa-wand-magic::before {
+  content: "\f0d0"; }
+
+.fa-magic::before {
+  content: "\f0d0"; }
+
+.fa-dog::before {
+  content: "\f6d3"; }
+
+.fa-carrot::before {
+  content: "\f787"; }
+
+.fa-moon::before {
+  content: "\f186"; }
+
+.fa-wine-glass-empty::before {
+  content: "\f5ce"; }
+
+.fa-wine-glass-alt::before {
+  content: "\f5ce"; }
+
+.fa-cheese::before {
+  content: "\f7ef"; }
+
+.fa-yin-yang::before {
+  content: "\f6ad"; }
+
+.fa-music::before {
+  content: "\f001"; }
+
+.fa-code-commit::before {
+  content: "\f386"; }
+
+.fa-temperature-low::before {
+  content: "\f76b"; }
+
+.fa-person-biking::before {
+  content: "\f84a"; }
+
+.fa-biking::before {
+  content: "\f84a"; }
+
+.fa-broom::before {
+  content: "\f51a"; }
+
+.fa-shield-heart::before {
+  content: "\e574"; }
+
+.fa-gopuram::before {
+  content: "\f664"; }
+
+.fa-earth-oceania::before {
+  content: "\e47b"; }
+
+.fa-globe-oceania::before {
+  content: "\e47b"; }
+
+.fa-square-xmark::before {
+  content: "\f2d3"; }
+
+.fa-times-square::before {
+  content: "\f2d3"; }
+
+.fa-xmark-square::before {
+  content: "\f2d3"; }
+
+.fa-hashtag::before {
+  content: "\23"; }
+
+.fa-up-right-and-down-left-from-center::before {
+  content: "\f424"; }
+
+.fa-expand-alt::before {
+  content: "\f424"; }
+
+.fa-oil-can::before {
+  content: "\f613"; }
+
+.fa-t::before {
+  content: "\54"; }
+
+.fa-hippo::before {
+  content: "\f6ed"; }
+
+.fa-chart-column::before {
+  content: "\e0e3"; }
+
+.fa-infinity::before {
+  content: "\f534"; }
+
+.fa-vial-circle-check::before {
+  content: "\e596"; }
+
+.fa-person-arrow-down-to-line::before {
+  content: "\e538"; }
+
+.fa-voicemail::before {
+  content: "\f897"; }
+
+.fa-fan::before {
+  content: "\f863"; }
+
+.fa-person-walking-luggage::before {
+  content: "\e554"; }
+
+.fa-up-down::before {
+  content: "\f338"; }
+
+.fa-arrows-alt-v::before {
+  content: "\f338"; }
+
+.fa-cloud-moon-rain::before {
+  content: "\f73c"; }
+
+.fa-calendar::before {
+  content: "\f133"; }
+
+.fa-trailer::before {
+  content: "\e041"; }
+
+.fa-bahai::before {
+  content: "\f666"; }
+
+.fa-haykal::before {
+  content: "\f666"; }
+
+.fa-sd-card::before {
+  content: "\f7c2"; }
+
+.fa-dragon::before {
+  content: "\f6d5"; }
+
+.fa-shoe-prints::before {
+  content: "\f54b"; }
+
+.fa-circle-plus::before {
+  content: "\f055"; }
+
+.fa-plus-circle::before {
+  content: "\f055"; }
+
+.fa-face-grin-tongue-wink::before {
+  content: "\f58b"; }
+
+.fa-grin-tongue-wink::before {
+  content: "\f58b"; }
+
+.fa-hand-holding::before {
+  content: "\f4bd"; }
+
+.fa-plug-circle-exclamation::before {
+  content: "\e55d"; }
+
+.fa-link-slash::before {
+  content: "\f127"; }
+
+.fa-chain-broken::before {
+  content: "\f127"; }
+
+.fa-chain-slash::before {
+  content: "\f127"; }
+
+.fa-unlink::before {
+  content: "\f127"; }
+
+.fa-clone::before {
+  content: "\f24d"; }
+
+.fa-person-walking-arrow-loop-left::before {
+  content: "\e551"; }
+
+.fa-arrow-up-z-a::before {
+  content: "\f882"; }
+
+.fa-sort-alpha-up-alt::before {
+  content: "\f882"; }
+
+.fa-fire-flame-curved::before {
+  content: "\f7e4"; }
+
+.fa-fire-alt::before {
+  content: "\f7e4"; }
+
+.fa-tornado::before {
+  content: "\f76f"; }
+
+.fa-file-circle-plus::before {
+  content: "\e494"; }
+
+.fa-book-quran::before {
+  content: "\f687"; }
+
+.fa-quran::before {
+  content: "\f687"; }
+
+.fa-anchor::before {
+  content: "\f13d"; }
+
+.fa-border-all::before {
+  content: "\f84c"; }
+
+.fa-face-angry::before {
+  content: "\f556"; }
+
+.fa-angry::before {
+  content: "\f556"; }
+
+.fa-cookie-bite::before {
+  content: "\f564"; }
+
+.fa-arrow-trend-down::before {
+  content: "\e097"; }
+
+.fa-rss::before {
+  content: "\f09e"; }
+
+.fa-feed::before {
+  content: "\f09e"; }
+
+.fa-draw-polygon::before {
+  content: "\f5ee"; }
+
+.fa-scale-balanced::before {
+  content: "\f24e"; }
+
+.fa-balance-scale::before {
+  content: "\f24e"; }
+
+.fa-gauge-simple-high::before {
+  content: "\f62a"; }
+
+.fa-tachometer::before {
+  content: "\f62a"; }
+
+.fa-tachometer-fast::before {
+  content: "\f62a"; }
+
+.fa-shower::before {
+  content: "\f2cc"; }
+
+.fa-desktop::before {
+  content: "\f390"; }
+
+.fa-desktop-alt::before {
+  content: "\f390"; }
+
+.fa-m::before {
+  content: "\4d"; }
+
+.fa-table-list::before {
+  content: "\f00b"; }
+
+.fa-th-list::before {
+  content: "\f00b"; }
+
+.fa-comment-sms::before {
+  content: "\f7cd"; }
+
+.fa-sms::before {
+  content: "\f7cd"; }
+
+.fa-book::before {
+  content: "\f02d"; }
+
+.fa-user-plus::before {
+  content: "\f234"; }
+
+.fa-check::before {
+  content: "\f00c"; }
+
+.fa-battery-three-quarters::before {
+  content: "\f241"; }
+
+.fa-battery-4::before {
+  content: "\f241"; }
+
+.fa-house-circle-check::before {
+  content: "\e509"; }
+
+.fa-angle-left::before {
+  content: "\f104"; }
+
+.fa-diagram-successor::before {
+  content: "\e47a"; }
+
+.fa-truck-arrow-right::before {
+  content: "\e58b"; }
+
+.fa-arrows-split-up-and-left::before {
+  content: "\e4bc"; }
+
+.fa-hand-fist::before {
+  content: "\f6de"; }
+
+.fa-fist-raised::before {
+  content: "\f6de"; }
+
+.fa-cloud-moon::before {
+  content: "\f6c3"; }
+
+.fa-briefcase::before {
+  content: "\f0b1"; }
+
+.fa-person-falling::before {
+  content: "\e546"; }
+
+.fa-image-portrait::before {
+  content: "\f3e0"; }
+
+.fa-portrait::before {
+  content: "\f3e0"; }
+
+.fa-user-tag::before {
+  content: "\f507"; }
+
+.fa-rug::before {
+  content: "\e569"; }
+
+.fa-earth-europe::before {
+  content: "\f7a2"; }
+
+.fa-globe-europe::before {
+  content: "\f7a2"; }
+
+.fa-cart-flatbed-suitcase::before {
+  content: "\f59d"; }
+
+.fa-luggage-cart::before {
+  content: "\f59d"; }
+
+.fa-rectangle-xmark::before {
+  content: "\f410"; }
+
+.fa-rectangle-times::before {
+  content: "\f410"; }
+
+.fa-times-rectangle::before {
+  content: "\f410"; }
+
+.fa-window-close::before {
+  content: "\f410"; }
+
+.fa-baht-sign::before {
+  content: "\e0ac"; }
+
+.fa-book-open::before {
+  content: "\f518"; }
+
+.fa-book-journal-whills::before {
+  content: "\f66a"; }
+
+.fa-journal-whills::before {
+  content: "\f66a"; }
+
+.fa-handcuffs::before {
+  content: "\e4f8"; }
+
+.fa-triangle-exclamation::before {
+  content: "\f071"; }
+
+.fa-exclamation-triangle::before {
+  content: "\f071"; }
+
+.fa-warning::before {
+  content: "\f071"; }
+
+.fa-database::before {
+  content: "\f1c0"; }
+
+.fa-share::before {
+  content: "\f064"; }
+
+.fa-arrow-turn-right::before {
+  content: "\f064"; }
+
+.fa-mail-forward::before {
+  content: "\f064"; }
+
+.fa-bottle-droplet::before {
+  content: "\e4c4"; }
+
+.fa-mask-face::before {
+  content: "\e1d7"; }
+
+.fa-hill-rockslide::before {
+  content: "\e508"; }
+
+.fa-right-left::before {
+  content: "\f362"; }
+
+.fa-exchange-alt::before {
+  content: "\f362"; }
+
+.fa-paper-plane::before {
+  content: "\f1d8"; }
+
+.fa-road-circle-exclamation::before {
+  content: "\e565"; }
+
+.fa-dungeon::before {
+  content: "\f6d9"; }
+
+.fa-align-right::before {
+  content: "\f038"; }
+
+.fa-money-bill-1-wave::before {
+  content: "\f53b"; }
+
+.fa-money-bill-wave-alt::before {
+  content: "\f53b"; }
+
+.fa-life-ring::before {
+  content: "\f1cd"; }
+
+.fa-hands::before {
+  content: "\f2a7"; }
+
+.fa-sign-language::before {
+  content: "\f2a7"; }
+
+.fa-signing::before {
+  content: "\f2a7"; }
+
+.fa-calendar-day::before {
+  content: "\f783"; }
+
+.fa-water-ladder::before {
+  content: "\f5c5"; }
+
+.fa-ladder-water::before {
+  content: "\f5c5"; }
+
+.fa-swimming-pool::before {
+  content: "\f5c5"; }
+
+.fa-arrows-up-down::before {
+  content: "\f07d"; }
+
+.fa-arrows-v::before {
+  content: "\f07d"; }
+
+.fa-face-grimace::before {
+  content: "\f57f"; }
+
+.fa-grimace::before {
+  content: "\f57f"; }
+
+.fa-wheelchair-move::before {
+  content: "\e2ce"; }
+
+.fa-wheelchair-alt::before {
+  content: "\e2ce"; }
+
+.fa-turn-down::before {
+  content: "\f3be"; }
+
+.fa-level-down-alt::before {
+  content: "\f3be"; }
+
+.fa-person-walking-arrow-right::before {
+  content: "\e552"; }
+
+.fa-square-envelope::before {
+  content: "\f199"; }
+
+.fa-envelope-square::before {
+  content: "\f199"; }
+
+.fa-dice::before {
+  content: "\f522"; }
+
+.fa-bowling-ball::before {
+  content: "\f436"; }
+
+.fa-brain::before {
+  content: "\f5dc"; }
+
+.fa-bandage::before {
+  content: "\f462"; }
+
+.fa-band-aid::before {
+  content: "\f462"; }
+
+.fa-calendar-minus::before {
+  content: "\f272"; }
+
+.fa-circle-xmark::before {
+  content: "\f057"; }
+
+.fa-times-circle::before {
+  content: "\f057"; }
+
+.fa-xmark-circle::before {
+  content: "\f057"; }
+
+.fa-gifts::before {
+  content: "\f79c"; }
+
+.fa-hotel::before {
+  content: "\f594"; }
+
+.fa-earth-asia::before {
+  content: "\f57e"; }
+
+.fa-globe-asia::before {
+  content: "\f57e"; }
+
+.fa-id-card-clip::before {
+  content: "\f47f"; }
+
+.fa-id-card-alt::before {
+  content: "\f47f"; }
+
+.fa-magnifying-glass-plus::before {
+  content: "\f00e"; }
+
+.fa-search-plus::before {
+  content: "\f00e"; }
+
+.fa-thumbs-up::before {
+  content: "\f164"; }
+
+.fa-user-clock::before {
+  content: "\f4fd"; }
+
+.fa-hand-dots::before {
+  content: "\f461"; }
+
+.fa-allergies::before {
+  content: "\f461"; }
+
+.fa-file-invoice::before {
+  content: "\f570"; }
+
+.fa-window-minimize::before {
+  content: "\f2d1"; }
+
+.fa-mug-saucer::before {
+  content: "\f0f4"; }
+
+.fa-coffee::before {
+  content: "\f0f4"; }
+
+.fa-brush::before {
+  content: "\f55d"; }
+
+.fa-mask::before {
+  content: "\f6fa"; }
+
+.fa-magnifying-glass-minus::before {
+  content: "\f010"; }
+
+.fa-search-minus::before {
+  content: "\f010"; }
+
+.fa-ruler-vertical::before {
+  content: "\f548"; }
+
+.fa-user-large::before {
+  content: "\f406"; }
+
+.fa-user-alt::before {
+  content: "\f406"; }
+
+.fa-train-tram::before {
+  content: "\e5b4"; }
+
+.fa-user-nurse::before {
+  content: "\f82f"; }
+
+.fa-syringe::before {
+  content: "\f48e"; }
+
+.fa-cloud-sun::before {
+  content: "\f6c4"; }
+
+.fa-stopwatch-20::before {
+  content: "\e06f"; }
+
+.fa-square-full::before {
+  content: "\f45c"; }
+
+.fa-magnet::before {
+  content: "\f076"; }
+
+.fa-jar::before {
+  content: "\e516"; }
+
+.fa-note-sticky::before {
+  content: "\f249"; }
+
+.fa-sticky-note::before {
+  content: "\f249"; }
+
+.fa-bug-slash::before {
+  content: "\e490"; }
+
+.fa-arrow-up-from-water-pump::before {
+  content: "\e4b6"; }
+
+.fa-bone::before {
+  content: "\f5d7"; }
+
+.fa-user-injured::before {
+  content: "\f728"; }
+
+.fa-face-sad-tear::before {
+  content: "\f5b4"; }
+
+.fa-sad-tear::before {
+  content: "\f5b4"; }
+
+.fa-plane::before {
+  content: "\f072"; }
+
+.fa-tent-arrows-down::before {
+  content: "\e581"; }
+
+.fa-exclamation::before {
+  content: "\21"; }
+
+.fa-arrows-spin::before {
+  content: "\e4bb"; }
+
+.fa-print::before {
+  content: "\f02f"; }
+
+.fa-turkish-lira-sign::before {
+  content: "\e2bb"; }
+
+.fa-try::before {
+  content: "\e2bb"; }
+
+.fa-turkish-lira::before {
+  content: "\e2bb"; }
+
+.fa-dollar-sign::before {
+  content: "\24"; }
+
+.fa-dollar::before {
+  content: "\24"; }
+
+.fa-usd::before {
+  content: "\24"; }
+
+.fa-x::before {
+  content: "\58"; }
+
+.fa-magnifying-glass-dollar::before {
+  content: "\f688"; }
+
+.fa-search-dollar::before {
+  content: "\f688"; }
+
+.fa-users-gear::before {
+  content: "\f509"; }
+
+.fa-users-cog::before {
+  content: "\f509"; }
+
+.fa-person-military-pointing::before {
+  content: "\e54a"; }
+
+.fa-building-columns::before {
+  content: "\f19c"; }
+
+.fa-bank::before {
+  content: "\f19c"; }
+
+.fa-institution::before {
+  content: "\f19c"; }
+
+.fa-museum::before {
+  content: "\f19c"; }
+
+.fa-university::before {
+  content: "\f19c"; }
+
+.fa-umbrella::before {
+  content: "\f0e9"; }
+
+.fa-trowel::before {
+  content: "\e589"; }
+
+.fa-d::before {
+  content: "\44"; }
+
+.fa-stapler::before {
+  content: "\e5af"; }
+
+.fa-masks-theater::before {
+  content: "\f630"; }
+
+.fa-theater-masks::before {
+  content: "\f630"; }
+
+.fa-kip-sign::before {
+  content: "\e1c4"; }
+
+.fa-hand-point-left::before {
+  content: "\f0a5"; }
+
+.fa-handshake-simple::before {
+  content: "\f4c6"; }
+
+.fa-handshake-alt::before {
+  content: "\f4c6"; }
+
+.fa-jet-fighter::before {
+  content: "\f0fb"; }
+
+.fa-fighter-jet::before {
+  content: "\f0fb"; }
+
+.fa-square-share-nodes::before {
+  content: "\f1e1"; }
+
+.fa-share-alt-square::before {
+  content: "\f1e1"; }
+
+.fa-barcode::before {
+  content: "\f02a"; }
+
+.fa-plus-minus::before {
+  content: "\e43c"; }
+
+.fa-video::before {
+  content: "\f03d"; }
+
+.fa-video-camera::before {
+  content: "\f03d"; }
+
+.fa-graduation-cap::before {
+  content: "\f19d"; }
+
+.fa-mortar-board::before {
+  content: "\f19d"; }
+
+.fa-hand-holding-medical::before {
+  content: "\e05c"; }
+
+.fa-person-circle-check::before {
+  content: "\e53e"; }
+
+.fa-turn-up::before {
+  content: "\f3bf"; }
+
+.fa-level-up-alt::before {
+  content: "\f3bf"; }
+
+.sr-only,
+.fa-sr-only {
+  position: absolute;
+  width: 1px;
+  height: 1px;
+  padding: 0;
+  margin: -1px;
+  overflow: hidden;
+  clip: rect(0, 0, 0, 0);
+  white-space: nowrap;
+  border-width: 0; }
+
+.sr-only-focusable:not(:focus),
+.fa-sr-only-focusable:not(:focus) {
+  position: absolute;
+  width: 1px;
+  height: 1px;
+  padding: 0;
+  margin: -1px;
+  overflow: hidden;
+  clip: rect(0, 0, 0, 0);
+  white-space: nowrap;
+  border-width: 0; }
+:root, :host {
+  --fa-style-family-brands: 'Font Awesome 6 Brands';
+  --fa-font-brands: normal 400 1em/1 'Font Awesome 6 Brands'; }
+
+@font-face {
+  font-family: 'Font Awesome 6 Brands';
+  font-style: normal;
+  font-weight: 400;
+  font-display: block;
+  src: url("../webfonts/fa-brands-400.woff2") format("woff2"), url("../webfonts/fa-brands-400.ttf") format("truetype"); }
+
+.fab,
+.fa-brands {
+  font-weight: 400; }
+
+.fa-monero:before {
+  content: "\f3d0"; }
+
+.fa-hooli:before {
+  content: "\f427"; }
+
+.fa-yelp:before {
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+.fa-pied-piper-square:before {
+  content: "\e01e"; }
+
+.fa-creative-commons-nd:before {
+  content: "\f4eb"; }
+
+.fa-palfed:before {
+  content: "\f3d8"; }
+
+.fa-superpowers:before {
+  content: "\f2dd"; }
+
+.fa-resolving:before {
+  content: "\f3e7"; }
+
+.fa-xbox:before {
+  content: "\f412"; }
+
+.fa-searchengin:before {
+  content: "\f3eb"; }
+
+.fa-tiktok:before {
+  content: "\e07b"; }
+
+.fa-square-facebook:before {
+  content: "\f082"; }
+
+.fa-facebook-square:before {
+  content: "\f082"; }
+
+.fa-renren:before {
+  content: "\f18b"; }
+
+.fa-linux:before {
+  content: "\f17c"; }
+
+.fa-glide:before {
+  content: "\f2a5"; }
+
+.fa-linkedin:before {
+  content: "\f08c"; }
+
+.fa-hubspot:before {
+  content: "\f3b2"; }
+
+.fa-deploydog:before {
+  content: "\f38e"; }
+
+.fa-twitch:before {
+  content: "\f1e8"; }
+
+.fa-ravelry:before {
+  content: "\f2d9"; }
+
+.fa-mixer:before {
+  content: "\e056"; }
+
+.fa-square-lastfm:before {
+  content: "\f203"; }
+
+.fa-lastfm-square:before {
+  content: "\f203"; }
+
+.fa-vimeo:before {
+  content: "\f40a"; }
+
+.fa-mendeley:before {
+  content: "\f7b3"; }
+
+.fa-uniregistry:before {
+  content: "\f404"; }
+
+.fa-figma:before {
+  content: "\f799"; }
+
+.fa-creative-commons-remix:before {
+  content: "\f4ee"; }
+
+.fa-cc-amazon-pay:before {
+  content: "\f42d"; }
+
+.fa-dropbox:before {
+  content: "\f16b"; }
+
+.fa-instagram:before {
+  content: "\f16d"; }
+
+.fa-cmplid:before {
+  content: "\e360"; }
+
+.fa-facebook:before {
+  content: "\f09a"; }
+
+.fa-gripfire:before {
+  content: "\f3ac"; }
+
+.fa-jedi-order:before {
+  content: "\f50e"; }
+
+.fa-uikit:before {
+  content: "\f403"; }
+
+.fa-fort-awesome-alt:before {
+  content: "\f3a3"; }
+
+.fa-phabricator:before {
+  content: "\f3db"; }
+
+.fa-ussunnah:before {
+  content: "\f407"; }
+
+.fa-earlybirds:before {
+  content: "\f39a"; }
+
+.fa-trade-federation:before {
+  content: "\f513"; }
+
+.fa-autoprefixer:before {
+  content: "\f41c"; }
+
+.fa-whatsapp:before {
+  content: "\f232"; }
+
+.fa-slideshare:before {
+  content: "\f1e7"; }
+
+.fa-google-play:before {
+  content: "\f3ab"; }
+
+.fa-viadeo:before {
+  content: "\f2a9"; }
+
+.fa-line:before {
+  content: "\f3c0"; }
+
+.fa-google-drive:before {
+  content: "\f3aa"; }
+
+.fa-servicestack:before {
+  content: "\f3ec"; }
+
+.fa-simplybuilt:before {
+  content: "\f215"; }
+
+.fa-bitbucket:before {
+  content: "\f171"; }
+
+.fa-imdb:before {
+  content: "\f2d8"; }
+
+.fa-deezer:before {
+  content: "\e077"; }
+
+.fa-raspberry-pi:before {
+  content: "\f7bb"; }
+
+.fa-jira:before {
+  content: "\f7b1"; }
+
+.fa-docker:before {
+  content: "\f395"; }
+
+.fa-screenpal:before {
+  content: "\e570"; }
+
+.fa-bluetooth:before {
+  content: "\f293"; }
+
+.fa-gitter:before {
+  content: "\f426"; }
+
+.fa-d-and-d:before {
+  content: "\f38d"; }
+
+.fa-microblog:before {
+  content: "\e01a"; }
+
+.fa-cc-diners-club:before {
+  content: "\f24c"; }
+
+.fa-gg-circle:before {
+  content: "\f261"; }
+
+.fa-pied-piper-hat:before {
+  content: "\f4e5"; }
+
+.fa-kickstarter-k:before {
+  content: "\f3bc"; }
+
+.fa-yandex:before {
+  content: "\f413"; }
+
+.fa-readme:before {
+  content: "\f4d5"; }
+
+.fa-html5:before {
+  content: "\f13b"; }
+
+.fa-sellsy:before {
+  content: "\f213"; }
+
+.fa-sass:before {
+  content: "\f41e"; }
+
+.fa-wirsindhandwerk:before {
+  content: "\e2d0"; }
+
+.fa-wsh:before {
+  content: "\e2d0"; }
+
+.fa-buromobelexperte:before {
+  content: "\f37f"; }
+
+.fa-salesforce:before {
+  content: "\f83b"; }
+
+.fa-octopus-deploy:before {
+  content: "\e082"; }
+
+.fa-medapps:before {
+  content: "\f3c6"; }
+
+.fa-ns8:before {
+  content: "\f3d5"; }
+
+.fa-pinterest-p:before {
+  content: "\f231"; }
+
+.fa-apper:before {
+  content: "\f371"; }
+
+.fa-fort-awesome:before {
+  content: "\f286"; }
+
+.fa-waze:before {
+  content: "\f83f"; }
+
+.fa-cc-jcb:before {
+  content: "\f24b"; }
+
+.fa-snapchat:before {
+  content: "\f2ab"; }
+
+.fa-snapchat-ghost:before {
+  content: "\f2ab"; }
+
+.fa-fantasy-flight-games:before {
+  content: "\f6dc"; }
+
+.fa-rust:before {
+  content: "\e07a"; }
+
+.fa-wix:before {
+  content: "\f5cf"; }
+
+.fa-square-behance:before {
+  content: "\f1b5"; }
+
+.fa-behance-square:before {
+  content: "\f1b5"; }
+
+.fa-supple:before {
+  content: "\f3f9"; }
+
+.fa-rebel:before {
+  content: "\f1d0"; }
+
+.fa-css3:before {
+  content: "\f13c"; }
+
+.fa-staylinked:before {
+  content: "\f3f5"; }
+
+.fa-kaggle:before {
+  content: "\f5fa"; }
+
+.fa-space-awesome:before {
+  content: "\e5ac"; }
+
+.fa-deviantart:before {
+  content: "\f1bd"; }
+
+.fa-cpanel:before {
+  content: "\f388"; }
+
+.fa-goodreads-g:before {
+  content: "\f3a9"; }
+
+.fa-square-git:before {
+  content: "\f1d2"; }
+
+.fa-git-square:before {
+  content: "\f1d2"; }
+
+.fa-square-tumblr:before {
+  content: "\f174"; }
+
+.fa-tumblr-square:before {
+  content: "\f174"; }
+
+.fa-trello:before {
+  content: "\f181"; }
+
+.fa-creative-commons-nc-jp:before {
+  content: "\f4ea"; }
+
+.fa-get-pocket:before {
+  content: "\f265"; }
+
+.fa-perbyte:before {
+  content: "\e083"; }
+
+.fa-grunt:before {
+  content: "\f3ad"; }
+
+.fa-weebly:before {
+  content: "\f5cc"; }
+
+.fa-connectdevelop:before {
+  content: "\f20e"; }
+
+.fa-leanpub:before {
+  content: "\f212"; }
+
+.fa-black-tie:before {
+  content: "\f27e"; }
+
+.fa-themeco:before {
+  content: "\f5c6"; }
+
+.fa-python:before {
+  content: "\f3e2"; }
+
+.fa-android:before {
+  content: "\f17b"; }
+
+.fa-bots:before {
+  content: "\e340"; }
+
+.fa-free-code-camp:before {
+  content: "\f2c5"; }
+
+.fa-hornbill:before {
+  content: "\f592"; }
+
+.fa-js:before {
+  content: "\f3b8"; }
+
+.fa-ideal:before {
+  content: "\e013"; }
+
+.fa-git:before {
+  content: "\f1d3"; }
+
+.fa-dev:before {
+  content: "\f6cc"; }
+
+.fa-sketch:before {
+  content: "\f7c6"; }
+
+.fa-yandex-international:before {
+  content: "\f414"; }
+
+.fa-cc-amex:before {
+  content: "\f1f3"; }
+
+.fa-uber:before {
+  content: "\f402"; }
+
+.fa-github:before {
+  content: "\f09b"; }
+
+.fa-php:before {
+  content: "\f457"; }
+
+.fa-alipay:before {
+  content: "\f642"; }
+
+.fa-youtube:before {
+  content: "\f167"; }
+
+.fa-skyatlas:before {
+  content: "\f216"; }
+
+.fa-firefox-browser:before {
+  content: "\e007"; }
+
+.fa-replyd:before {
+  content: "\f3e6"; }
+
+.fa-suse:before {
+  content: "\f7d6"; }
+
+.fa-jenkins:before {
+  content: "\f3b6"; }
+
+.fa-twitter:before {
+  content: "\f099"; }
+
+.fa-rockrms:before {
+  content: "\f3e9"; }
+
+.fa-pinterest:before {
+  content: "\f0d2"; }
+
+.fa-buffer:before {
+  content: "\f837"; }
+
+.fa-npm:before {
+  content: "\f3d4"; }
+
+.fa-yammer:before {
+  content: "\f840"; }
+
+.fa-btc:before {
+  content: "\f15a"; }
+
+.fa-dribbble:before {
+  content: "\f17d"; }
+
+.fa-stumbleupon-circle:before {
+  content: "\f1a3"; }
+
+.fa-internet-explorer:before {
+  content: "\f26b"; }
+
+.fa-stubber:before {
+  content: "\e5c7"; }
+
+.fa-telegram:before {
+  content: "\f2c6"; }
+
+.fa-telegram-plane:before {
+  content: "\f2c6"; }
+
+.fa-old-republic:before {
+  content: "\f510"; }
+
+.fa-odysee:before {
+  content: "\e5c6"; }
+
+.fa-square-whatsapp:before {
+  content: "\f40c"; }
+
+.fa-whatsapp-square:before {
+  content: "\f40c"; }
+
+.fa-node-js:before {
+  content: "\f3d3"; }
+
+.fa-edge-legacy:before {
+  content: "\e078"; }
+
+.fa-slack:before {
+  content: "\f198"; }
+
+.fa-slack-hash:before {
+  content: "\f198"; }
+
+.fa-medrt:before {
+  content: "\f3c8"; }
+
+.fa-usb:before {
+  content: "\f287"; }
+
+.fa-tumblr:before {
+  content: "\f173"; }
+
+.fa-vaadin:before {
+  content: "\f408"; }
+
+.fa-quora:before {
+  content: "\f2c4"; }
+
+.fa-square-x-twitter:before {
+  content: "\e61a"; }
+
+.fa-reacteurope:before {
+  content: "\f75d"; }
+
+.fa-medium:before {
+  content: "\f23a"; }
+
+.fa-medium-m:before {
+  content: "\f23a"; }
+
+.fa-amilia:before {
+  content: "\f36d"; }
+
+.fa-mixcloud:before {
+  content: "\f289"; }
+
+.fa-flipboard:before {
+  content: "\f44d"; }
+
+.fa-viacoin:before {
+  content: "\f237"; }
+
+.fa-critical-role:before {
+  content: "\f6c9"; }
+
+.fa-sitrox:before {
+  content: "\e44a"; }
+
+.fa-discourse:before {
+  content: "\f393"; }
+
+.fa-joomla:before {
+  content: "\f1aa"; }
+
+.fa-mastodon:before {
+  content: "\f4f6"; }
+
+.fa-airbnb:before {
+  content: "\f834"; }
+
+.fa-wolf-pack-battalion:before {
+  content: "\f514"; }
+
+.fa-buy-n-large:before {
+  content: "\f8a6"; }
+
+.fa-gulp:before {
+  content: "\f3ae"; }
+
+.fa-creative-commons-sampling-plus:before {
+  content: "\f4f1"; }
+
+.fa-strava:before {
+  content: "\f428"; }
+
+.fa-ember:before {
+  content: "\f423"; }
+
+.fa-canadian-maple-leaf:before {
+  content: "\f785"; }
+
+.fa-teamspeak:before {
+  content: "\f4f9"; }
+
+.fa-pushed:before {
+  content: "\f3e1"; }
+
+.fa-wordpress-simple:before {
+  content: "\f411"; }
+
+.fa-nutritionix:before {
+  content: "\f3d6"; }
+
+.fa-wodu:before {
+  content: "\e088"; }
+
+.fa-google-pay:before {
+  content: "\e079"; }
+
+.fa-intercom:before {
+  content: "\f7af"; }
+
+.fa-zhihu:before {
+  content: "\f63f"; }
+
+.fa-korvue:before {
+  content: "\f42f"; }
+
+.fa-pix:before {
+  content: "\e43a"; }
+
+.fa-steam-symbol:before {
+  content: "\f3f6"; }
+:root, :host {
+  --fa-style-family-classic: 'Font Awesome 6 Free';
+  --fa-font-regular: normal 400 1em/1 'Font Awesome 6 Free'; }
+
+@font-face {
+  font-family: 'Font Awesome 6 Free';
+  font-style: normal;
+  font-weight: 400;
+  font-display: block;
+  src: url("../webfonts/fa-regular-400.woff2") format("woff2"), url("../webfonts/fa-regular-400.ttf") format("truetype"); }
+
+.far,
+.fa-regular {
+  font-weight: 400; }
+:root, :host {
+  --fa-style-family-classic: 'Font Awesome 6 Free';
+  --fa-font-solid: normal 900 1em/1 'Font Awesome 6 Free'; }
+
+@font-face {
+  font-family: 'Font Awesome 6 Free';
+  font-style: normal;
+  font-weight: 900;
+  font-display: block;
+  src: url("../webfonts/fa-solid-900.woff2") format("woff2"), url("../webfonts/fa-solid-900.ttf") format("truetype"); }
+
+.fas,
+.fa-solid {
+  font-weight: 900; }
+@font-face {
+  font-family: 'Font Awesome 5 Brands';
+  font-display: block;
+  font-weight: 400;
+  src: url("../webfonts/fa-brands-400.woff2") format("woff2"), url("../webfonts/fa-brands-400.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'Font Awesome 5 Free';
+  font-display: block;
+  font-weight: 900;
+  src: url("../webfonts/fa-solid-900.woff2") format("woff2"), url("../webfonts/fa-solid-900.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'Font Awesome 5 Free';
+  font-display: block;
+  font-weight: 400;
+  src: url("../webfonts/fa-regular-400.woff2") format("woff2"), url("../webfonts/fa-regular-400.ttf") format("truetype"); }
+@font-face {
+  font-family: 'FontAwesome';
+  font-display: block;
+  src: url("../webfonts/fa-solid-900.woff2") format("woff2"), url("../webfonts/fa-solid-900.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'FontAwesome';
+  font-display: block;
+  src: url("../webfonts/fa-brands-400.woff2") format("woff2"), url("../webfonts/fa-brands-400.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'FontAwesome';
+  font-display: block;
+  src: url("../webfonts/fa-regular-400.woff2") format("woff2"), url("../webfonts/fa-regular-400.ttf") format("truetype"); }
+
+@font-face {
+  font-family: 'FontAwesome';
+  font-display: block;
+  src: url("../webfonts/fa-v4compatibility.woff2") format("woff2"), url("../webfonts/fa-v4compatibility.ttf") format("truetype"); }
diff --git a/deps/font-awesome-6.4.2/css/all.min.css b/deps/font-awesome-6.4.2/css/all.min.css
new file mode 100644
index 0000000..6604a06
--- /dev/null
+++ b/deps/font-awesome-6.4.2/css/all.min.css
@@ -0,0 +1,9 @@
+/*!
+ * Font Awesome Free 6.4.2 by @fontawesome - https://fontawesome.com
+ * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)
+ * Copyright 2023 Fonticons, Inc.
+ */
+.fa{font-family:var(--fa-style-family,"Font Awesome 6 Free");font-weight:var(--fa-style,900)}.fa,.fa-brands,.fa-classic,.fa-regular,.fa-sharp,.fa-solid,.fab,.far,.fas{-moz-osx-font-smoothing:grayscale;-webkit-font-smoothing:antialiased;display:var(--fa-display,inline-block);font-style:normal;font-variant:normal;line-height:1;text-rendering:auto}.fa-classic,.fa-regular,.fa-solid,.far,.fas{font-family:"Font Awesome 6 Free"}.fa-brands,.fab{font-family:"Font Awesome 6 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diff --git a/deps/font-awesome-6.4.2/css/v4-shims.css b/deps/font-awesome-6.4.2/css/v4-shims.css
new file mode 100644
index 0000000..a85953d
--- /dev/null
+++ b/deps/font-awesome-6.4.2/css/v4-shims.css
@@ -0,0 +1,2194 @@
+/*!
+ * Font Awesome Free 6.4.2 by @fontawesome - https://fontawesome.com
+ * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)
+ * Copyright 2023 Fonticons, Inc.
+ */
+.fa.fa-glass:before {
+  content: "\f000"; }
+
+.fa.fa-envelope-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-envelope-o:before {
+  content: "\f0e0"; }
+
+.fa.fa-star-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-star-o:before {
+  content: "\f005"; }
+
+.fa.fa-remove:before {
+  content: "\f00d"; }
+
+.fa.fa-close:before {
+  content: "\f00d"; }
+
+.fa.fa-gear:before {
+  content: "\f013"; }
+
+.fa.fa-trash-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-trash-o:before {
+  content: "\f2ed"; }
+
+.fa.fa-home:before {
+  content: "\f015"; }
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+.fa.fa-file-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-file-o:before {
+  content: "\f15b"; }
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+.fa.fa-clock-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-clock-o:before {
+  content: "\f017"; }
+
+.fa.fa-arrow-circle-o-down {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-arrow-circle-o-down:before {
+  content: "\f358"; }
+
+.fa.fa-arrow-circle-o-up {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-arrow-circle-o-up:before {
+  content: "\f35b"; }
+
+.fa.fa-play-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-play-circle-o:before {
+  content: "\f144"; }
+
+.fa.fa-repeat:before {
+  content: "\f01e"; }
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+.fa.fa-rotate-right:before {
+  content: "\f01e"; }
+
+.fa.fa-refresh:before {
+  content: "\f021"; }
+
+.fa.fa-list-alt {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-list-alt:before {
+  content: "\f022"; }
+
+.fa.fa-dedent:before {
+  content: "\f03b"; }
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+.fa.fa-video-camera:before {
+  content: "\f03d"; }
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+.fa.fa-picture-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+  content: "\f03e"; }
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+.fa.fa-photo {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-photo:before {
+  content: "\f03e"; }
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+.fa.fa-image {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-image:before {
+  content: "\f03e"; }
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+.fa.fa-map-marker:before {
+  content: "\f3c5"; }
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+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-pencil-square-o:before {
+  content: "\f044"; }
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+.fa.fa-edit {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-edit:before {
+  content: "\f044"; }
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+.fa.fa-share-square-o:before {
+  content: "\f14d"; }
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+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-check-square-o:before {
+  content: "\f14a"; }
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+.fa.fa-arrows:before {
+  content: "\f0b2"; }
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+.fa.fa-times-circle-o {
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+  font-weight: 400; }
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+.fa.fa-times-circle-o:before {
+  content: "\f057"; }
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+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-check-circle-o:before {
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+.fa.fa-compress:before {
+  content: "\f422"; }
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+.fa.fa-eye {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-eye-slash {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
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+.fa.fa-warning:before {
+  content: "\f071"; }
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+.fa.fa-calendar:before {
+  content: "\f073"; }
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+  content: "\f338"; }
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+  content: "\f337"; }
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+.fa.fa-bar-chart:before {
+  content: "\e0e3"; }
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+.fa.fa-bar-chart-o:before {
+  content: "\e0e3"; }
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+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
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+  font-weight: 400; }
+
+.fa.fa-pause-circle-o:before {
+  content: "\f28b"; }
+
+.fa.fa-stop-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-stop-circle-o:before {
+  content: "\f28d"; }
+
+.fa.fa-bluetooth {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-bluetooth-b {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-gitlab {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wpbeginner {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wpforms {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-envira {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wheelchair-alt {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wheelchair-alt:before {
+  content: "\f368"; }
+
+.fa.fa-question-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-question-circle-o:before {
+  content: "\f059"; }
+
+.fa.fa-volume-control-phone:before {
+  content: "\f2a0"; }
+
+.fa.fa-asl-interpreting:before {
+  content: "\f2a3"; }
+
+.fa.fa-deafness:before {
+  content: "\f2a4"; }
+
+.fa.fa-hard-of-hearing:before {
+  content: "\f2a4"; }
+
+.fa.fa-glide {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-glide-g {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-signing:before {
+  content: "\f2a7"; }
+
+.fa.fa-viadeo {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-viadeo-square {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-viadeo-square:before {
+  content: "\f2aa"; }
+
+.fa.fa-snapchat {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-snapchat-ghost {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-snapchat-ghost:before {
+  content: "\f2ab"; }
+
+.fa.fa-snapchat-square {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-snapchat-square:before {
+  content: "\f2ad"; }
+
+.fa.fa-pied-piper {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-first-order {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-yoast {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-themeisle {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-google-plus-official {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-google-plus-official:before {
+  content: "\f2b3"; }
+
+.fa.fa-google-plus-circle {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-google-plus-circle:before {
+  content: "\f2b3"; }
+
+.fa.fa-font-awesome {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-fa {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-fa:before {
+  content: "\f2b4"; }
+
+.fa.fa-handshake-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-handshake-o:before {
+  content: "\f2b5"; }
+
+.fa.fa-envelope-open-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-envelope-open-o:before {
+  content: "\f2b6"; }
+
+.fa.fa-linode {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-address-book-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-address-book-o:before {
+  content: "\f2b9"; }
+
+.fa.fa-vcard:before {
+  content: "\f2bb"; }
+
+.fa.fa-address-card-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-address-card-o:before {
+  content: "\f2bb"; }
+
+.fa.fa-vcard-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-vcard-o:before {
+  content: "\f2bb"; }
+
+.fa.fa-user-circle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-user-circle-o:before {
+  content: "\f2bd"; }
+
+.fa.fa-user-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-user-o:before {
+  content: "\f007"; }
+
+.fa.fa-id-badge {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-drivers-license:before {
+  content: "\f2c2"; }
+
+.fa.fa-id-card-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-id-card-o:before {
+  content: "\f2c2"; }
+
+.fa.fa-drivers-license-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-drivers-license-o:before {
+  content: "\f2c2"; }
+
+.fa.fa-quora {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-free-code-camp {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-telegram {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-thermometer-4:before {
+  content: "\f2c7"; }
+
+.fa.fa-thermometer:before {
+  content: "\f2c7"; }
+
+.fa.fa-thermometer-3:before {
+  content: "\f2c8"; }
+
+.fa.fa-thermometer-2:before {
+  content: "\f2c9"; }
+
+.fa.fa-thermometer-1:before {
+  content: "\f2ca"; }
+
+.fa.fa-thermometer-0:before {
+  content: "\f2cb"; }
+
+.fa.fa-bathtub:before {
+  content: "\f2cd"; }
+
+.fa.fa-s15:before {
+  content: "\f2cd"; }
+
+.fa.fa-window-maximize {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-window-restore {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-times-rectangle:before {
+  content: "\f410"; }
+
+.fa.fa-window-close-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-window-close-o:before {
+  content: "\f410"; }
+
+.fa.fa-times-rectangle-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-times-rectangle-o:before {
+  content: "\f410"; }
+
+.fa.fa-bandcamp {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-grav {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-etsy {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-imdb {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-ravelry {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-eercast {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-eercast:before {
+  content: "\f2da"; }
+
+.fa.fa-snowflake-o {
+  font-family: 'Font Awesome 6 Free';
+  font-weight: 400; }
+
+.fa.fa-snowflake-o:before {
+  content: "\f2dc"; }
+
+.fa.fa-superpowers {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-wpexplorer {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
+
+.fa.fa-meetup {
+  font-family: 'Font Awesome 6 Brands';
+  font-weight: 400; }
diff --git a/deps/font-awesome-6.4.2/css/v4-shims.min.css b/deps/font-awesome-6.4.2/css/v4-shims.min.css
new file mode 100644
index 0000000..64e4e8d
--- /dev/null
+++ b/deps/font-awesome-6.4.2/css/v4-shims.min.css
@@ -0,0 +1,6 @@
+/*!
+ * Font Awesome Free 6.4.2 by @fontawesome - https://fontawesome.com
+ * License - https://fontawesome.com/license/free (Icons: CC BY 4.0, Fonts: SIL OFL 1.1, Code: MIT License)
+ * Copyright 2023 Fonticons, Inc.
+ */
+.fa.fa-glass:before{content:"\f000"}.fa.fa-envelope-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-envelope-o:before{content:"\f0e0"}.fa.fa-star-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-star-o:before{content:"\f005"}.fa.fa-close:before,.fa.fa-remove:before{content:"\f00d"}.fa.fa-gear:before{content:"\f013"}.fa.fa-trash-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-trash-o:before{content:"\f2ed"}.fa.fa-home:before{content:"\f015"}.fa.fa-file-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-file-o:before{content:"\f15b"}.fa.fa-clock-o{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-clock-o:before{content:"\f017"}.fa.fa-arrow-circle-o-down{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-arrow-circle-o-down:before{content:"\f358"}.fa.fa-arrow-circle-o-up{font-family:"Font Awesome 6 Free";font-weight:400}.fa.fa-arrow-circle-o-up:before{content:"\f35b"}.fa.fa-play-circle-o{font-family:"Font Awesome 6 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+/*!
+ * headroom.js v0.11.0 - Give your page some headroom. Hide your header until you need it
+ * Copyright (c) 2020 Nick Williams - http://wicky.nillia.ms/headroom.js
+ * License: MIT
+ */
+
+!function(t,n){"object"==typeof exports&&"undefined"!=typeof module?module.exports=n():"function"==typeof define&&define.amd?define(n):(t=t||self).Headroom=n()}(this,function(){"use strict";function t(){return"undefined"!=typeof window}function d(t){return function(t){return t&&t.document&&function(t){return 9===t.nodeType}(t.document)}(t)?function(t){var n=t.document,o=n.body,s=n.documentElement;return{scrollHeight:function(){return Math.max(o.scrollHeight,s.scrollHeight,o.offsetHeight,s.offsetHeight,o.clientHeight,s.clientHeight)},height:function(){return t.innerHeight||s.clientHeight||o.clientHeight},scrollY:function(){return void 0!==t.pageYOffset?t.pageYOffset:(s||o.parentNode||o).scrollTop}}}(t):function(t){return{scrollHeight:function(){return Math.max(t.scrollHeight,t.offsetHeight,t.clientHeight)},height:function(){return Math.max(t.offsetHeight,t.clientHeight)},scrollY:function(){return t.scrollTop}}}(t)}function n(t,s,e){var n,o=function(){var n=!1;try{var t={get passive(){n=!0}};window.addEventListener("test",t,t),window.removeEventListener("test",t,t)}catch(t){n=!1}return n}(),i=!1,r=d(t),l=r.scrollY(),a={};function c(){var t=Math.round(r.scrollY()),n=r.height(),o=r.scrollHeight();a.scrollY=t,a.lastScrollY=l,a.direction=l<t?"down":"up",a.distance=Math.abs(t-l),a.isOutOfBounds=t<0||o<t+n,a.top=t<=s.offset,a.bottom=o<=t+n,a.toleranceExceeded=a.distance>s.tolerance[a.direction],e(a),l=t,i=!1}function h(){i||(i=!0,n=requestAnimationFrame(c))}var u=!!o&&{passive:!0,capture:!1};return t.addEventListener("scroll",h,u),c(),{destroy:function(){cancelAnimationFrame(n),t.removeEventListener("scroll",h,u)}}}function o(t,n){n=n||{},Object.assign(this,o.options,n),this.classes=Object.assign({},o.options.classes,n.classes),this.elem=t,this.tolerance=function(t){return t===Object(t)?t:{down:t,up:t}}(this.tolerance),this.initialised=!1,this.frozen=!1}return o.prototype={constructor:o,init:function(){return o.cutsTheMustard&&!this.initialised&&(this.addClass("initial"),this.initialised=!0,setTimeout(function(t){t.scrollTracker=n(t.scroller,{offset:t.offset,tolerance:t.tolerance},t.update.bind(t))},100,this)),this},destroy:function(){this.initialised=!1,Object.keys(this.classes).forEach(this.removeClass,this),this.scrollTracker.destroy()},unpin:function(){!this.hasClass("pinned")&&this.hasClass("unpinned")||(this.addClass("unpinned"),this.removeClass("pinned"),this.onUnpin&&this.onUnpin.call(this))},pin:function(){this.hasClass("unpinned")&&(this.addClass("pinned"),this.removeClass("unpinned"),this.onPin&&this.onPin.call(this))},freeze:function(){this.frozen=!0,this.addClass("frozen")},unfreeze:function(){this.frozen=!1,this.removeClass("frozen")},top:function(){this.hasClass("top")||(this.addClass("top"),this.removeClass("notTop"),this.onTop&&this.onTop.call(this))},notTop:function(){this.hasClass("notTop")||(this.addClass("notTop"),this.removeClass("top"),this.onNotTop&&this.onNotTop.call(this))},bottom:function(){this.hasClass("bottom")||(this.addClass("bottom"),this.removeClass("notBottom"),this.onBottom&&this.onBottom.call(this))},notBottom:function(){this.hasClass("notBottom")||(this.addClass("notBottom"),this.removeClass("bottom"),this.onNotBottom&&this.onNotBottom.call(this))},shouldUnpin:function(t){return"down"===t.direction&&!t.top&&t.toleranceExceeded},shouldPin:function(t){return"up"===t.direction&&t.toleranceExceeded||t.top},addClass:function(t){this.elem.classList.add.apply(this.elem.classList,this.classes[t].split(" "))},removeClass:function(t){this.elem.classList.remove.apply(this.elem.classList,this.classes[t].split(" "))},hasClass:function(t){return this.classes[t].split(" ").every(function(t){return this.classList.contains(t)},this.elem)},update:function(t){t.isOutOfBounds||!0!==this.frozen&&(t.top?this.top():this.notTop(),t.bottom?this.bottom():this.notBottom(),this.shouldUnpin(t)?this.unpin():this.shouldPin(t)&&this.pin())}},o.options={tolerance:{up:0,down:0},offset:0,scroller:t()?window:null,classes:{frozen:"headroom--frozen",pinned:"headroom--pinned",unpinned:"headroom--unpinned",top:"headroom--top",notTop:"headroom--not-top",bottom:"headroom--bottom",notBottom:"headroom--not-bottom",initial:"headroom"}},o.cutsTheMustard=!!(t()&&function(){}.bind&&"classList"in document.documentElement&&Object.assign&&Object.keys&&requestAnimationFrame),o});
\ No newline at end of file
diff --git a/deps/headroom-0.11.0/jQuery.headroom.min.js b/deps/headroom-0.11.0/jQuery.headroom.min.js
new file mode 100644
index 0000000..17f70c9
--- /dev/null
+++ b/deps/headroom-0.11.0/jQuery.headroom.min.js
@@ -0,0 +1,7 @@
+/*!
+ * headroom.js v0.9.4 - Give your page some headroom. Hide your header until you need it
+ * Copyright (c) 2017 Nick Williams - http://wicky.nillia.ms/headroom.js
+ * License: MIT
+ */
+
+!function(a){a&&(a.fn.headroom=function(b){return this.each(function(){var c=a(this),d=c.data("headroom"),e="object"==typeof b&&b;e=a.extend(!0,{},Headroom.options,e),d||(d=new Headroom(this,e),d.init(),c.data("headroom",d)),"string"==typeof b&&(d[b](),"destroy"===b&&c.removeData("headroom"))})},a("[data-headroom]").each(function(){var b=a(this);b.headroom(b.data())}))}(window.Zepto||window.jQuery);
\ No newline at end of file
diff --git a/deps/search-1.0.0/autocomplete.jquery.min.js b/deps/search-1.0.0/autocomplete.jquery.min.js
new file mode 100644
index 0000000..fb63a6a
--- /dev/null
+++ b/deps/search-1.0.0/autocomplete.jquery.min.js
@@ -0,0 +1,7 @@
+/*!
+ * autocomplete.js 0.38.0
+ * https://github.com/algolia/autocomplete.js
+ * Copyright 2020 Algolia, Inc. and other contributors; Licensed MIT
+ */
+!function(a){function b(d){if(c[d])return c[d].exports;var e=c[d]={exports:{},id:d,loaded:!1};return a[d].call(e.exports,e,e.exports,b),e.loaded=!0,e.exports}var c={};b.m=a,b.c=c,b.p="",b(0)}([function(a,b,c){"use strict";a.exports=c(1)},function(a,b,c){"use strict";var d=c(2),e=c(3);d.element=e;var f=c(4);f.isArray=e.isArray,f.isFunction=e.isFunction,f.isObject=e.isPlainObject,f.bind=e.proxy,f.each=function(a,b){function c(a,c){return b(c,a)}e.each(a,c)},f.map=e.map,f.mixin=e.extend,f.Event=e.Event;var g,h,i,j=c(5),k=c(6);g=e.fn.autocomplete,h="aaAutocomplete",i={initialize:function(a,b){function c(){var c,d=e(this),f=new k({el:d});c=new j({input:d,eventBus:f,dropdownMenuContainer:a.dropdownMenuContainer,hint:void 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i[a]&&"initialize"!==a?(b=this.filter(function(){return!!e(this).data(h)}),i[a].apply(b,[].slice.call(arguments,1))):i.initialize.apply(this,arguments)},e.fn.autocomplete.noConflict=function(){return e.fn.autocomplete=g,this},e.fn.autocomplete.sources=j.sources,e.fn.autocomplete.escapeHighlightedString=f.escapeHighlightedString,a.exports=e.fn.autocomplete},function(a,b){"use strict";a.exports={element:null}},function(a,b){a.exports=jQuery},function(a,b,c){"use strict";function d(a){return a.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&")}var e=c(2);a.exports={isArray:null,isFunction:null,isObject:null,bind:null,each:null,map:null,mixin:null,isMsie:function(a){if(void 0===a&&(a=navigator.userAgent),/(msie|trident)/i.test(a)){var b=a.match(/(msie |rv:)(\d+(.\d+)?)/i);if(b)return b[2]}return!1},escapeRegExChars:function(a){return a.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&")},isNumber:function(a){return"number"==typeof a},toStr:function(a){return void 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f=document.createElement("div");f.appendChild(document.createTextNode(c));var g=document.createElement("div");return g.appendChild(document.createTextNode(a)),g.innerHTML.replace(RegExp(d(e.innerHTML),"g"),b).replace(RegExp(d(f.innerHTML),"g"),c)}}},function(a,b,c){"use strict";function d(a){var b,c;if(a=a||{},a.input||i.error("missing input"),this.isActivated=!1,this.debug=!!a.debug,this.autoselect=!!a.autoselect,this.autoselectOnBlur=!!a.autoselectOnBlur,this.openOnFocus=!!a.openOnFocus,this.minLength=i.isNumber(a.minLength)?a.minLength:1,this.autoWidth=void 0===a.autoWidth||!!a.autoWidth,this.clearOnSelected=!!a.clearOnSelected,this.tabAutocomplete=void 0===a.tabAutocomplete||!!a.tabAutocomplete,a.hint=!!a.hint,a.hint&&a.appendTo)throw new Error("[autocomplete.js] hint and appendTo options can't be used at the same 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d.Dropdown({appendTo:a.appendTo,wrapper:this.$node,menu:b,datasets:a.datasets,templates:a.templates,cssClasses:a.cssClasses,minLength:this.minLength}).onSync("suggestionClicked",this._onSuggestionClicked,this).onSync("cursorMoved",this._onCursorMoved,this).onSync("cursorRemoved",this._onCursorRemoved,this).onSync("opened",this._onOpened,this).onSync("closed",this._onClosed,this).onSync("shown",this._onShown,this).onSync("empty",this._onEmpty,this).onSync("redrawn",this._onRedrawn,this).onAsync("datasetRendered",this._onDatasetRendered,this),this.input=new 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g=n.dropdown.replace("%PREFIX%",a.cssClasses.prefix).replace("%DROPDOWN_MENU%",a.cssClasses.dropdownMenu);d=j.element(g).css(a.css.dropdown).attr({role:"listbox",id:a.listboxId}),a.templates&&a.templates.dropdownMenu&&d.html(i.templatify(a.templates.dropdownMenu)()),e=b.clone().css(a.css.hint).css(f(b)),e.val("").addClass(i.className(a.cssClasses.prefix,a.cssClasses.hint,!0)).removeAttr("id name placeholder required").prop("readonly",!0).attr({"aria-hidden":"true",autocomplete:"off",spellcheck:"false",tabindex:-1}),e.removeData&&e.removeData(),b.data(h,{"aria-autocomplete":b.attr("aria-autocomplete"),"aria-expanded":b.attr("aria-expanded"),"aria-owns":b.attr("aria-owns"),autocomplete:b.attr("autocomplete"),dir:b.attr("dir"),role:b.attr("role"),spellcheck:b.attr("spellcheck"),style:b.attr("style"),type:b.attr("type")}),b.addClass(i.className(a.cssClasses.prefix,a.cssClasses.input,!0)).attr({autocomplete:"off",spellcheck:!1,role:"combobox","aria-autocomplete":a.datasets&&a.datasets[0]&&a.datasets[0].displayKey?"both":"list","aria-expanded":"false","aria-label":a.ariaLabel,"aria-owns":a.listboxId}).css(a.hint?a.css.input:a.css.inputWithNoHint);try{b.attr("dir")||b.attr("dir","auto")}catch(a){}return c=a.appendTo?c.appendTo(j.element(a.appendTo).eq(0)).eq(0):b.wrap(c).parent(),c.prepend(a.hint?e:null).append(d),{wrapper:c,input:b,hint:e,menu:d}}function f(a){return{backgroundAttachment:a.css("background-attachment"),backgroundClip:a.css("background-clip"),backgroundColor:a.css("background-color"),backgroundImage:a.css("background-image"),backgroundOrigin:a.css("background-origin"),backgroundPosition:a.css("background-position"),backgroundRepeat:a.css("background-repeat"),backgroundSize:a.css("background-size")}}function g(a,b){var c=a.find(i.className(b.prefix,b.input));i.each(c.data(h),function(a,b){void 0===a?c.removeAttr(b):c.attr(b,a)}),c.detach().removeClass(i.className(b.prefix,b.input,!0)).insertAfter(a),c.removeData&&c.removeData(h),a.remove()}var h="aaAttrs",i=c(4),j=c(2),k=c(6),l=c(7),m=c(16),n=c(18),o=c(19);i.mixin(d.prototype,{_bindKeyboardShortcuts:function(a){if(a.keyboardShortcuts){var b=this.$input,c=[];i.each(a.keyboardShortcuts,function(a){"string"==typeof a&&(a=a.toUpperCase().charCodeAt(0)),c.push(a)}),j.element(document).keydown(function(a){var 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c=this.dropdown.getDatumForCursor(),d=this.dropdown.getCurrentCursor().attr("id");this.input.setActiveDescendant(d),c&&(b&&this.input.setInputValue(c.value,!0),this.eventBus.trigger("cursorchanged",c.raw,c.datasetName))},_onCursorRemoved:function(){this.input.resetInputValue(),this._updateHint(),this.eventBus.trigger("cursorremoved")},_onDatasetRendered:function(){this._updateHint(),this.eventBus.trigger("updated")},_onOpened:function(){this._updateHint(),this.input.expand(),this.eventBus.trigger("opened")},_onEmpty:function(){this.eventBus.trigger("empty")},_onRedrawn:function(){this.$node.css("top","0px"),this.$node.css("left","0px");var a=this.$input[0].getBoundingClientRect();this.autoWidth&&this.$node.css("width",a.width+"px");var b=this.$node[0].getBoundingClientRect(),c=a.bottom-b.top;this.$node.css("top",c+"px");var d=a.left-b.left;this.$node.css("left",d+"px"),this.eventBus.trigger("redrawn")},_onShown:function(){this.eventBus.trigger("shown"),this.autoselect&&this.dropdown.cursorTopSuggestion()},_onClosed:function(){this.input.clearHint(),this.input.removeActiveDescendant(),this.input.collapse(),this.eventBus.trigger("closed")},_onFocused:function(){if(this.isActivated=!0,this.openOnFocus){var a=this.input.getQuery();a.length>=this.minLength?this.dropdown.update(a):this.dropdown.empty(),this.dropdown.open()}},_onBlurred:function(){var a,b;a=this.dropdown.getDatumForCursor(),b=this.dropdown.getDatumForTopSuggestion();var c={selectionMethod:"blur"};this.debug||(this.autoselectOnBlur&&a?this._select(a,c):this.autoselectOnBlur&&b?this._select(b,c):(this.isActivated=!1,this.dropdown.empty(),this.dropdown.close()))},_onEnterKeyed:function(a,b){var c,d;c=this.dropdown.getDatumForCursor(),d=this.dropdown.getDatumForTopSuggestion();var 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a=this.input.getInputValue();a.length>=this.minLength?this.dropdown.update(a):this.dropdown.empty()}this.dropdown.open()},close:function(){this.dropdown.close()},setVal:function(a){a=i.toStr(a),this.isActivated?this.input.setInputValue(a):(this.input.setQuery(a),this.input.setInputValue(a,!0)),this._setLanguageDirection()},getVal:function(){return this.input.getQuery()},destroy:function(){this.input.destroy(),this.dropdown.destroy(),g(this.$node,this.cssClasses),this.$node=null},getWrapper:function(){return this.dropdown.$container[0]}}),d.Dropdown=m,d.Input=l,d.sources=c(20),a.exports=d},function(a,b,c){"use strict";function d(a){a&&a.el||e.error("EventBus initialized without el"),this.$el=f.element(a.el)}var e=c(4),f=c(2);e.mixin(d.prototype,{trigger:function(a,b,c,d){var f=e.Event("autocomplete:"+a);return this.$el.trigger(f,[b,c,d]),f}}),a.exports=d},function(a,b,c){"use strict";function d(a){var b,c,d,f,g=this;a=a||{},a.input||i.error("input is 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+var c=[].slice.call(arguments,1);this.cacheSuggestions(a,b,c),this._render.apply(this,[a,b].concat(c))}}if(this.query=a,this.canceled=!1,this.shouldFetchFromCache(a))b.apply(this,[this.cachedSuggestions].concat(this.cachedRenderExtraArgs));else{var c=this,d=function(){c.canceled||c.source(a,b.bind(c))};if(this.debounce){var e=function(){c.debounceTimeout=null,d()};clearTimeout(this.debounceTimeout),this.debounceTimeout=setTimeout(e,this.debounce)}else d()}},cacheSuggestions:function(a,b,c){this.cachedQuery=a,this.cachedSuggestions=b,this.cachedRenderExtraArgs=c},shouldFetchFromCache:function(a){return this.cache&&this.cachedQuery===a&&this.cachedSuggestions&&this.cachedSuggestions.length},clearCachedSuggestions:function(){delete this.cachedQuery,delete this.cachedSuggestions,delete this.cachedRenderExtraArgs},cancel:function(){this.canceled=!0},clear:function(){this.$el&&(this.cancel(),this.$el.empty(),this.trigger("rendered",""))},isEmpty:function(){return this._isEmpty},destroy:function(){this.clearCachedSuggestions(),this.$el=null}}),a.exports=d},function(a,b){"use strict";a.exports={wrapper:'<span class="%ROOT%"></span>',dropdown:'<span class="%PREFIX%%DROPDOWN_MENU%"></span>',dataset:'<div class="%PREFIX%%DATASET%-%CLASS%"></div>',suggestions:'<span class="%PREFIX%%SUGGESTIONS%"></span>',suggestion:'<div class="%PREFIX%%SUGGESTION%"></div>'}},function(a,b,c){"use strict";var d=c(4),e={wrapper:{position:"relative",display:"inline-block"},hint:{position:"absolute",top:"0",left:"0",borderColor:"transparent",boxShadow:"none",opacity:"1"},input:{position:"relative",verticalAlign:"top",backgroundColor:"transparent"},inputWithNoHint:{position:"relative",verticalAlign:"top"},dropdown:{position:"absolute",top:"100%",left:"0",zIndex:"100",display:"none"},suggestions:{display:"block"},suggestion:{whiteSpace:"nowrap",cursor:"pointer"},suggestionChild:{whiteSpace:"normal"},ltr:{left:"0",right:"auto"},rtl:{left:"auto",right:"0"},defaultClasses:{root:"algolia-autocomplete",prefix:"aa",noPrefix:!1,dropdownMenu:"dropdown-menu",input:"input",hint:"hint",suggestions:"suggestions",suggestion:"suggestion",cursor:"cursor",dataset:"dataset",empty:"empty"},appendTo:{wrapper:{position:"absolute",zIndex:"100",display:"none"},input:{},inputWithNoHint:{},dropdown:{display:"block"}}};d.isMsie()&&d.mixin(e.input,{backgroundImage:"url(data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)"}),d.isMsie()&&d.isMsie()<=7&&d.mixin(e.input,{marginTop:"-1px"}),a.exports=e},function(a,b,c){"use strict";a.exports={hits:c(21),popularIn:c(24)}},function(a,b,c){"use strict";var d=c(4),e=c(22),f=c(23),g=function(){function a(a,d){return window.Promise.resolve().then(function(){return b.length&&(e=a.search(b),b=[]),e}).then(function(a){if(a)return c=a.results,c[d]})}var b=[],c=[],e=window.Promise.resolve();return function(c,e){return function(f,g){a(c.as,b.push({indexName:c.indexName,query:f,params:e})-1).then(function(a){a&&g(a.hits,a)}).catch(function(a){d.error(a.message)})}}}();a.exports=function(a,b){var c=f(a.as._ua);if(c&&c[0]>=3&&c[1]>20){var d="autocomplete.js "+e;a.as._ua.indexOf(d)===-1&&(a.as._ua+="; "+d)}return g(a,b)}},function(a,b){a.exports="0.38.0"},function(a,b){"use strict";a.exports=function(a){var b=a.match(/Algolia for JavaScript \((\d+\.)(\d+\.)(\d+)\)/)||a.match(/Algolia for vanilla JavaScript (\d+\.)(\d+\.)(\d+)/);if(b)return[b[1],b[2],b[3]]}},function(a,b,c){"use strict";var d=c(4),e=c(22),f=c(23);a.exports=function(a,b,c,g){function h(h,i){a.search(h,b,function(a,h){if(a)return void d.error(a.message);if(h.hits.length>0){var l=h.hits[0],m=d.mixin({hitsPerPage:0},c);delete m.source,delete m.index;var n=f(k.as._ua);return n&&n[0]>=3&&n[1]>20&&(b.additionalUA="autocomplete.js "+e),void k.search(j(l),m,function(a,b){if(a)return void d.error(a.message);var c=[];if(g.includeAll){var e=g.allTitle||"All departments";c.push(d.mixin({facet:{value:e,count:b.nbHits}},d.cloneDeep(l)))}d.each(b.facets,function(a,b){d.each(a,function(a,e){c.push(d.mixin({facet:{facet:b,value:e,count:a}},d.cloneDeep(l)))})});for(var f=1;f<h.hits.length;++f)c.push(h.hits[f]);i(c,h)})}i([])})}var i=f(a.as._ua);if(i&&i[0]>=3&&i[1]>20&&(b=b||{},b.additionalUA="autocomplete.js "+e),!c.source)return d.error("Missing 'source' key");var j=d.isFunction(c.source)?c.source:function(a){return a[c.source]};if(!c.index)return d.error("Missing 'index' key");var k=c.index;return g=g||{},h}}]);
\ No newline at end of file
diff --git a/deps/search-1.0.0/fuse.min.js b/deps/search-1.0.0/fuse.min.js
new file mode 100644
index 0000000..7def598
--- /dev/null
+++ b/deps/search-1.0.0/fuse.min.js
@@ -0,0 +1,9 @@
+/**
+ * Fuse.js v6.4.6 - Lightweight fuzzy-search (http://fusejs.io)
+ *
+ * Copyright (c) 2021 Kiro Risk (http://kiro.me)
+ * All Rights Reserved. Apache Software License 2.0
+ *
+ * http://www.apache.org/licenses/LICENSE-2.0
+ */
+var e,t;e=this,t=function(){"use strict";function e(t){return(e="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(t)}function t(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")}function n(e,t){for(var n=0;n<t.length;n++){var r=t[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}function r(e,t,r){return t&&n(e.prototype,t),r&&n(e,r),e}function i(e,t,n){return t in e?Object.defineProperty(e,t,{value:n,enumerable:!0,configurable:!0,writable:!0}):e[t]=n,e}function o(e,t){var n=Object.keys(e);if(Object.getOwnPropertySymbols){var r=Object.getOwnPropertySymbols(e);t&&(r=r.filter((function(t){return Object.getOwnPropertyDescriptor(e,t).enumerable}))),n.push.apply(n,r)}return n}function c(e){for(var t=1;t<arguments.length;t++){var n=null!=arguments[t]?arguments[t]:{};t%2?o(Object(n),!0).forEach((function(t){i(e,t,n[t])})):Object.getOwnPropertyDescriptors?Object.defineProperties(e,Object.getOwnPropertyDescriptors(n)):o(Object(n)).forEach((function(t){Object.defineProperty(e,t,Object.getOwnPropertyDescriptor(n,t))}))}return e}function a(e,t){if("function"!=typeof t&&null!==t)throw new TypeError("Super expression must either be null or a function");e.prototype=Object.create(t&&t.prototype,{constructor:{value:e,writable:!0,configurable:!0}}),t&&u(e,t)}function s(e){return(s=Object.setPrototypeOf?Object.getPrototypeOf:function(e){return e.__proto__||Object.getPrototypeOf(e)})(e)}function u(e,t){return(u=Object.setPrototypeOf||function(e,t){return e.__proto__=t,e})(e,t)}function h(e,t){return!t||"object"!=typeof t&&"function"!=typeof t?function(e){if(void 0===e)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return e}(e):t}function f(e){var t=function(){if("undefined"==typeof 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\ No newline at end of file
diff --git a/deps/search-1.0.0/mark.min.js b/deps/search-1.0.0/mark.min.js
new file mode 100644
index 0000000..1eea053
--- /dev/null
+++ b/deps/search-1.0.0/mark.min.js
@@ -0,0 +1,7 @@
+/*!***************************************************
+* mark.js v8.11.1
+* https://markjs.io/
+* Copyright (c) 2014–2018, Julian Kühnel
+* Released under the MIT license https://git.io/vwTVl
+*****************************************************/
+!function(e,t){"object"==typeof exports&&"undefined"!=typeof module?module.exports=t():"function"==typeof define&&define.amd?define(t):e.Mark=t()}(this,function(){"use strict";var e="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e},t=function(e,t){if(!(e instanceof t))throw new TypeError("Cannot call a class as a function")},n=function(){function e(e,t){for(var n=0;n<t.length;n++){var r=t[n];r.enumerable=r.enumerable||!1,r.configurable=!0,"value"in r&&(r.writable=!0),Object.defineProperty(e,r.key,r)}}return function(t,n,r){return n&&e(t.prototype,n),r&&e(t,r),t}}(),r=Object.assign||function(e){for(var t=1;t<arguments.length;t++){var n=arguments[t];for(var r in n)Object.prototype.hasOwnProperty.call(n,r)&&(e[r]=n[r])}return e},i=function(){function e(n){var r=!(arguments.length>1&&void 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-    <a class="dropdown-item" href="articles/clinvar.html">C. ClinVar Integration</a>
-    <a class="dropdown-item" href="articles/issues.html">D. Issues &amp; Solutions</a>
-  </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="news/index.html">Changelog</a>
+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles">
+<li><a class="dropdown-item" href="articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="articles/issues.html">D. Issues &amp; Solutions</a></li>
+  </ul>
 </li>
+<li class="nav-item"><a class="nav-link" href="news/index.html">Changelog</a></li>
       </ul>
-<form class="form-inline my-2 my-lg-0" role="search">
-        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off">
-</form>
-
-      <ul class="navbar-nav">
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="github">
-    <span class="fab fa fab fa-github fa-lg"></span>
-     
-  </a>
-</li>
+<ul class="navbar-nav">
+<li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="search.json">
+</form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
       </ul>
 </div>
 
-    
+
   </div>
 </nav><div class="container template-home">
 <div class="row">
@@ -148,6 +134,7 @@ <h2 data-toc-skip>Developers</h2>
 <li>NIH NCI ITCR U24CA180996 <br><small class="roles"> Funder </small>  </li>
 <li>NIH NCI IOTN U24CA232979 <br><small class="roles"> Funder </small>  </li>
 <li>NIH NCI ARTNet U24CA274159 <br><small class="roles"> Funder </small>  </li>
+<li><a href="authors.html">More about authors...</a></li>
 </ul>
 </div>
 
@@ -162,15 +149,15 @@ <h2 data-toc-skip>Developers</h2>
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
 </div>
 
     </footer>
 </div>
 
-  
 
-  
+
+
 
   </body>
 </html>
diff --git a/katex-auto.js b/katex-auto.js
new file mode 100644
index 0000000..20651d9
--- /dev/null
+++ b/katex-auto.js
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+// https://github.com/jgm/pandoc/blob/29fa97ab96b8e2d62d48326e1b949a71dc41f47a/src/Text/Pandoc/Writers/HTML.hs#L332-L345
+document.addEventListener("DOMContentLoaded", function () {
+  var mathElements = document.getElementsByClassName("math");
+  var macros = [];
+  for (var i = 0; i < mathElements.length; i++) {
+    var texText = mathElements[i].firstChild;
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+        macros: macros,
+        fleqn: false
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+    }}});
diff --git a/lightswitch.js b/lightswitch.js
new file mode 100644
index 0000000..9467125
--- /dev/null
+++ b/lightswitch.js
@@ -0,0 +1,85 @@
+
+/*!
+ * Color mode toggler for Bootstrap's docs (https://getbootstrap.com/)
+ * Copyright 2011-2023 The Bootstrap Authors
+ * Licensed under the Creative Commons Attribution 3.0 Unported License.
+ * Updates for {pkgdown} by the {bslib} authors, also licensed under CC-BY-3.0.
+ */
+
+const getStoredTheme = () => localStorage.getItem('theme')
+const setStoredTheme = theme => localStorage.setItem('theme', theme)
+
+const getPreferredTheme = () => {
+  const storedTheme = getStoredTheme()
+  if (storedTheme) {
+    return storedTheme
+  }
+
+  return window.matchMedia('(prefers-color-scheme: dark)').matches ? 'dark' : 'light'
+}
+
+const setTheme = theme => {
+  if (theme === 'auto') {
+    document.documentElement.setAttribute('data-bs-theme', (window.matchMedia('(prefers-color-scheme: dark)').matches ? 'dark' : 'light'))
+  } else {
+    document.documentElement.setAttribute('data-bs-theme', theme)
+  }
+}
+
+function bsSetupThemeToggle () {
+  'use strict'
+
+  const showActiveTheme = (theme, focus = false) => {
+    var activeLabel, activeIcon;
+
+    document.querySelectorAll('[data-bs-theme-value]').forEach(element => {
+      const buttonTheme = element.getAttribute('data-bs-theme-value')
+      const isActive = buttonTheme == theme
+      
+      element.classList.toggle('active', isActive)
+      element.setAttribute('aria-pressed', isActive)
+
+      if (isActive) {
+        activeLabel = element.textContent;
+        activeIcon = element.querySelector('span').classList.value;
+      }
+    })
+
+    const themeSwitcher = document.querySelector('#dropdown-lightswitch')
+    if (!themeSwitcher) {
+      return
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+
+    themeSwitcher.setAttribute('aria-label', activeLabel)
+    themeSwitcher.querySelector('span').classList.value = activeIcon;
+
+    if (focus) {
+      themeSwitcher.focus()
+    }
+  }
+
+  window.matchMedia('(prefers-color-scheme: dark)').addEventListener('change', () => {
+    const storedTheme = getStoredTheme()
+    if (storedTheme !== 'light' && storedTheme !== 'dark') {
+      setTheme(getPreferredTheme())
+    }
+  })
+
+  window.addEventListener('DOMContentLoaded', () => {
+    showActiveTheme(getPreferredTheme())
+
+    document
+      .querySelectorAll('[data-bs-theme-value]')
+      .forEach(toggle => {
+        toggle.addEventListener('click', () => {
+          const theme = toggle.getAttribute('data-bs-theme-value')
+          setTheme(theme)
+          setStoredTheme(theme)
+          showActiveTheme(theme, true)
+        })
+      })
+  })
+}
+
+setTheme(getPreferredTheme());
+bsSetupThemeToggle();
diff --git a/news/index.html b/news/index.html
index bb4afa4..3cec1d6 100644
--- a/news/index.html
+++ b/news/index.html
@@ -1,61 +1,48 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Changelog • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Changelog"><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
-<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
-<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]--></head><body>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Changelog • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Changelog"></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
-    
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light" data-bs-theme="light"><div class="container">
-    
+
+    <nav class="navbar navbar-expand-lg fixed-top bg-light" data-bs-theme="light" aria-label="Site navigation"><div class="container">
+
     <a class="navbar-brand me-2" href="../index.html">AlphaMissenseR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.5</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
 
-    
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
       <span class="navbar-toggler-icon"></span>
     </button>
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
-      <ul class="navbar-nav me-auto"><li class="nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
-</li>
+      <ul class="navbar-nav me-auto"><li class="nav-item"><a class="nav-link" href="../reference/index.html">Reference</a></li>
 <li class="nav-item dropdown">
-  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
-  <div class="dropdown-menu" aria-labelledby="dropdown-articles">
-    <a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a>
-    <a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a>
-    <a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a>
-    <a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a>
-  </div>
-</li>
-<li class="active nav-item">
-  <a class="nav-link" href="../news/index.html">Changelog</a>
-</li>
-      </ul><form class="form-inline my-2 my-lg-0" role="search">
-        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
-
-      <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="github">
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-     
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-</li>
+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles"><li><a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a></li>
+  </ul></li>
+<li class="active nav-item"><a class="nav-link" href="../news/index.html">Changelog</a></li>
+      </ul><ul class="navbar-nav"><li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json"></form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
       </ul></div>
 
-    
+
   </div>
 </nav><div class="container template-news">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>Changelog</h1>
+
+      <h1>Changelog</h1>
       <small>Source: <a href="https://github.com/mtmorgan/AlphaMissenseR/blob/HEAD/NEWS.md" class="external-link"><code>NEWS.md</code></a></small>
     </div>
 
     <div class="section level2">
 <h2 class="pkg-version" data-toc-text="1.2.0" id="alphamissenser-120">AlphaMissenseR 1.2.0<a class="anchor" aria-label="anchor" href="#alphamissenser-120"></a></h2>
-<ul><li>(v. 1.1.4) Add <code><a href="../reference/ClinVar.html">clinvar_data()</a></code> and <code><a href="../reference/ClinVar.html">clinvar_plot()</a></code> for visualizing ClinVar data. Merges <a href="https://github.com/mtmorgan/AlphaMissenseR/pull/4" class="external-link uri">https://github.com/mtmorgan/AlphaMissenseR/pull/4</a> Thanks <a href="https://github.com/tram-nguyen-n" class="external-link">@tram-nguyen-n</a></li>
+<ul><li>(v. 1.1.6) Add <code><a href="../reference/Gosling.html">gosling_plot()</a></code> for visualizing variants as bar or lollipop plots</li>
+<li>(v. 1.1.4) Add <code><a href="../reference/ClinVar.html">clinvar_data()</a></code> and <code><a href="../reference/ClinVar.html">clinvar_plot()</a></code> for visualizing ClinVar data. Merges <a href="https://github.com/mtmorgan/AlphaMissenseR/pull/4" class="external-link uri">https://github.com/mtmorgan/AlphaMissenseR/pull/4</a> Thanks <a href="https://github.com/tram-nguyen-n" class="external-link">@tram-nguyen-n</a></li>
 <li>(v. 1.1.2) <code><a href="../reference/AlphaFold.html">af_predictions()</a></code> returns a tibble with 21 columns, instead of 20. Merges <a href="https://github.com/mtmorgan/AlphaMissenseR/pull/3" class="external-link uri">https://github.com/mtmorgan/AlphaMissenseR/pull/3</a>.</li>
 </ul></div>
     <div class="section level2">
@@ -87,7 +74,7 @@ <h2 class="pkg-version" data-toc-text="0.99.0" id="alphamissenser-0990">AlphaMis
 <ul><li>(v. 0.0.18) Rename (including updating existing tables) ‘#CHROM’ to ‘CHROM’ in hg19 / hg38 tables</li>
 <li>(v. 0.0.17) Initial Bioconductor submission.</li>
 </ul></div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside></div>
 
 
@@ -96,14 +83,14 @@ <h2 class="pkg-version" data-toc-text="0.99.0" id="alphamissenser-0990">AlphaMis
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
 </div>
 
     </footer></div>
 
-  
 
-  
+
+
 
   </body></html>
 
diff --git a/pkgdown.js b/pkgdown.js
index 9bd6621..9757bf9 100644
--- a/pkgdown.js
+++ b/pkgdown.js
@@ -152,5 +152,3 @@ async function searchFuse(query, callback) {
   });
   });
 })(window.jQuery || window.$)
-
-
diff --git a/pkgdown.yml b/pkgdown.yml
index 6f6e831..3b65491 100644
--- a/pkgdown.yml
+++ b/pkgdown.yml
@@ -1,13 +1,12 @@
-pandoc: 3.1.6.2
-pkgdown: 2.0.9
+pandoc: '3.3'
+pkgdown: 2.1.0
 pkgdown_sha: ~
 articles:
   alphafold: alphafold.html
   clinvar: clinvar.html
   introduction: introduction.html
   issues: issues.html
-last_built: 2024-06-26T18:04Z
+last_built: 2024-09-25T15:38Z
 urls:
   reference: https://mtmorgan.github.io/AlphaMissenseR/reference
   article: https://mtmorgan.github.io/AlphaMissenseR/articles
-
diff --git a/reference/AlphaFold.html b/reference/AlphaFold.html
index b2922b5..da81cac 100644
--- a/reference/AlphaFold.html
+++ b/reference/AlphaFold.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="af_predictions() retrieves information about
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>AlphaFold Protein Structure Retrieval and Display — af_predictions • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="AlphaFold Protein Structure Retrieval and Display — af_predictions"><meta name="description" content="af_predictions() retrieves information about
 AlphaFold predictions associated with UniProt accession
 identifiers.
 af_prediction_view() summarizes effects of possible
@@ -8,7 +8,7 @@
 af_colorfunc_by_position() generates a Javascript
 function to be used in rd3mol::m_set_style() to color
 residues by position, e.g., when visualizing median predicted
-pathogenicity."><title>AlphaFold Protein Structure Retrieval and Display — af_predictions • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="AlphaFold Protein Structure Retrieval and Display — af_predictions"><meta property="og:description" content="af_predictions() retrieves information about
+pathogenicity."><meta property="og:description" content="af_predictions() retrieves information about
 AlphaFold predictions associated with UniProt accession
 identifiers.
 af_prediction_view() summarizes effects of possible
@@ -17,57 +17,43 @@
 af_colorfunc_by_position() generates a Javascript
 function to be used in rd3mol::m_set_style() to color
 residues by position, e.g., when visualizing median predicted
-pathogenicity."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
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-<![endif]--><!-- dependencies from examples --><script src="libs/htmlwidgets-1.6.4/htmlwidgets.js"></script><script src="libs/r3dmol-1.6.2/3Dmol-nojquery-min.js"></script><script src="libs/r3dmol-binding-0.1.2/r3dmol.js"></script></head><body>
+pathogenicity."><!-- dependencies from examples --><script src="libs/htmlwidgets-1.6.4/htmlwidgets.js"></script><script src="libs/r3dmol-1.6.2/3Dmol-nojquery-min.js"></script><script src="libs/r3dmol-binding-0.1.2/r3dmol.js"></script></head><body>
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-      <img src="" class="logo" alt=""><h1>AlphaFold Protein Structure Retrieval and Display</h1>
+
+      <h1>AlphaFold Protein Structure Retrieval and Display</h1>
       <small class="dont-index">Source: <a href="https://github.com/mtmorgan/AlphaMissenseR/blob/HEAD/R/AlphaFold.R" class="external-link"><code>R/AlphaFold.R</code></a></small>
       <div class="d-none name"><code>AlphaFold.Rd</code></div>
     </div>
@@ -104,12 +90,14 @@ <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage">
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>uniprot_ids</dt>
+
+
+<dl><dt id="arg-uniprot-ids">uniprot_ids<a class="anchor" aria-label="anchor" href="#arg-uniprot-ids"></a></dt>
 <dd><p><code><a href="https://rdrr.io/r/base/character.html" class="external-link">character()</a></code> UniProt accession identifiers
 (<code>uniprot_id</code> in AlphaMissense tables).</p></dd>
 
 
-<dt>tbl</dt>
+<dt id="arg-tbl">tbl<a class="anchor" aria-label="anchor" href="#arg-tbl"></a></dt>
 <dd><p>A tibble containing information on the UniProt protein and
 AlphaMissense predicted amino acid effects.</p>
 <p>For <code>av_prediction_view()</code> the tibble must have columns
@@ -121,42 +109,42 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 and <code>value</code>, as described below.</p></dd>
 
 
-<dt>bfc</dt>
+<dt id="arg-bfc">bfc<a class="anchor" aria-label="anchor" href="#arg-bfc"></a></dt>
 <dd><p>An object created with <code><a href="https://rdrr.io/pkg/BiocFileCache/man/BiocFileCache-class.html" class="external-link">BiocFileCache::BiocFileCache()</a></code>,
 representing the location used to cache PDB files retrieved by
 <code>av_prediction_view()</code>. The default is the BiocFileCache
 installation-wide location.</p></dd>
 
 
-<dt>pos</dt>
+<dt id="arg-pos">pos<a class="anchor" aria-label="anchor" href="#arg-pos"></a></dt>
 <dd><p>the symbol or name of the column in <code>tbl</code> containing
 amino acid residue positions in the protein.</p></dd>
 
 
-<dt>value</dt>
+<dt id="arg-value">value<a class="anchor" aria-label="anchor" href="#arg-value"></a></dt>
 <dd><p>the symbol or name of the column in <code>tbl</code> containing
 values to be used for coloring amino acid residues in the
 protein.</p></dd>
 
 
-<dt>pos_max</dt>
+<dt id="arg-pos-max">pos_max<a class="anchor" aria-label="anchor" href="#arg-pos-max"></a></dt>
 <dd><p>integer(1) the maximum residue position in the
 protein to be visualized. Default: the maximum value in <code>pos</code>.</p></dd>
 
 
-<dt>palette</dt>
+<dt id="arg-palette">palette<a class="anchor" aria-label="anchor" href="#arg-palette"></a></dt>
 <dd><p>character() vector of colors to be used in
 visualization. The default (<code>colorspace::diverging_hcl(11)</code>)
 produces colors ranging from blue (low) to red (high).</p></dd>
 
 
-<dt>palette_min</dt>
+<dt id="arg-palette-min">palette_min<a class="anchor" aria-label="anchor" href="#arg-palette-min"></a></dt>
 <dd><p>numeric(1) the value bounding the minimum
 palette color. The default is the minimum of <code>value</code>; a common
 value when plotting pathogenicity might be <code>0</code>.</p></dd>
 
 
-<dt>palette_max</dt>
+<dt id="arg-palette-max">palette_max<a class="anchor" aria-label="anchor" href="#arg-palette-max"></a></dt>
 <dd><p>numeric(1) the value bounding the maximum
 palette color. The default is the maximum of <code>value</code>; a common
 value when plotting pathogenicity might be <code>1</code>.</p></dd>
@@ -164,9 +152,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    
-
-<p><code>af_predictions()</code> returns a tibble. Each row represents the
+    <p><code>af_predictions()</code> returns a tibble. Each row represents the
 AlphaFold prediction associated with the corresponding uniprot
 accession. Columns include:</p><ul><li><p><code>entryId</code>: AlphaFold identifier.</p></li>
 <li><p><code>gene</code>: gene symbol corresponding to UniProt protein.</p></li>
@@ -188,8 +174,6 @@ <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2
 <a href="https://alphafold.ebi.ac.uk/faq" class="external-link">https://alphafold.ebi.ac.uk/faq</a></p></li>
 </ul><p><code>af_prediction_view()</code> displays an interactive view of the protein
 in an RStudio panel or browser tab.</p>
-
-
 <p><code>af_colorfunc_by_position()</code> returns a character(1) vector
 representation of the Javascript function, with color vector
 injected.</p>
@@ -224,21 +208,22 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-in"><span>    <span class="fu"><a href="AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"aa_substitutions"</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
 <span class="r-in"><span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">uniprot_id</span> <span class="op">%like%</span> <span class="st">"P3555%"</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
 <span class="r-in"><span>    <span class="fu">dplyr</span><span class="fu">::</span><span class="fu"><a href="https://dplyr.tidyverse.org/reference/distinct.html" class="external-link">distinct</a></span><span class="op">(</span><span class="va">uniprot_id</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
-<span class="r-in"><span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/pull.html" class="external-link">pull</a></span><span class="op">(</span><span class="va">uniprot_id</span><span class="op">)</span></span></span>
+<span class="r-in"><span>    <span class="fu">pull</span><span class="op">(</span><span class="va">uniprot_id</span><span class="op">)</span></span></span>
 <span class="r-in"><span><span class="fu">af_predictions</span><span class="op">(</span><span class="va">uniprot_ids</span><span class="op">)</span></span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> * [14:04:32][info] 2 of 4 uniprot accessions not found</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   'P35555', 'P35556'</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># A tibble: 2 × 23</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   entryId      gene  uniprotAccession uniprotId   uniprotDescription       taxId</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>   <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>        <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>            <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>       <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>                    <span style="color: #949494; font-style: italic;">&lt;int&gt;</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;">1</span> AF-P35557-F1 GCK   P35557           HXK4_HUMAN  Hexokinase-4              <span style="text-decoration: underline;">9</span>606</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;">2</span> AF-P35558-F1 PCK1  P35558           PCKGC_HUMAN Phosphoenolpyruvate car…  <span style="text-decoration: underline;">9</span>606</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># ℹ 17 more variables: organismScientificName &lt;chr&gt;, uniprotStart &lt;int&gt;,</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;">#   uniprotEnd &lt;int&gt;, uniprotSequence &lt;chr&gt;, modelCreatedDate &lt;chr&gt;,</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;">#   latestVersion &lt;int&gt;, allVersions &lt;list&gt;, isReviewed &lt;lgl&gt;,</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;">#   isReferenceProteome &lt;lgl&gt;, cifUrl &lt;chr&gt;, bcifUrl &lt;chr&gt;, pdbUrl &lt;chr&gt;,</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;">#   paeImageUrl &lt;chr&gt;, paeDocUrl &lt;chr&gt;, amAnnotationsUrl &lt;chr&gt;,</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;">#   amAnnotationsHg19Url &lt;chr&gt;, amAnnotationsHg38Url &lt;chr&gt;</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> * [11:38:15][info] 2 of 4 uniprot accessions not found</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   'P35556', 'P35555'</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># A tibble: 2 × 25</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   entryId  gene  sequenceChecksum sequenceVersionDate uniprotAccession uniprotId</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>   <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>            <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>               <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>            <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>    </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;">1</span> AF-P355… PCK1  78D309E0845CC181 2006-03-07          P35558           PCKGC_HU…</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;">2</span> AF-P355… GCK   094D4A2F78096724 1994-06-01          P35557           HXK4_HUM…</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># ℹ 19 more variables: uniprotDescription &lt;chr&gt;, taxId &lt;int&gt;,</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;">#   organismScientificName &lt;chr&gt;, uniprotStart &lt;int&gt;, uniprotEnd &lt;int&gt;,</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;">#   uniprotSequence &lt;chr&gt;, modelCreatedDate &lt;chr&gt;, latestVersion &lt;int&gt;,</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;">#   allVersions &lt;list&gt;, isReviewed &lt;lgl&gt;, isReferenceProteome &lt;lgl&gt;,</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;">#   cifUrl &lt;chr&gt;, bcifUrl &lt;chr&gt;, pdbUrl &lt;chr&gt;, paeImageUrl &lt;chr&gt;,</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;">#   paeDocUrl &lt;chr&gt;, amAnnotationsUrl &lt;chr&gt;, amAnnotationsHg19Url &lt;chr&gt;,</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;">#   amAnnotationsHg38Url &lt;chr&gt;</span></span>
 <span class="r-in"><span></span></span>
 <span class="r-in"><span></span></span>
 <span class="r-in"><span><span class="co">## af_prediction_view()</span></span></span>
@@ -261,7 +246,7 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-in"><span></span></span>
 <span class="r-in"><span><span class="co">## af_colorfunc_by_position()</span></span></span>
 <span class="r-in"><span></span></span>
-<span class="r-in"><span><span class="va">df</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://tibble.tidyverse.org/reference/tibble.html" class="external-link">tibble</a></span><span class="op">(</span></span></span>
+<span class="r-in"><span><span class="va">df</span> <span class="op">&lt;-</span> <span class="fu">tibble</span><span class="op">(</span></span></span>
 <span class="r-in"><span>    pos <span class="op">=</span> <span class="fl">1</span> <span class="op">+</span> <span class="fl">1</span><span class="op">:</span><span class="fl">10</span>, <span class="co"># no color information for position 1</span></span></span>
 <span class="r-in"><span>    value <span class="op">=</span> <span class="fl">10</span><span class="op">:</span><span class="fl">1</span> <span class="op">/</span> <span class="fl">10</span></span></span>
 <span class="r-in"><span><span class="op">)</span></span></span>
@@ -288,7 +273,7 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-in"><span></span></span>
 </code></pre></div>
     </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside></div>
 
 
@@ -297,14 +282,14 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
 </div>
 
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-  
+
+
 
   </body></html>
 
diff --git a/reference/AlphaMissense.html b/reference/AlphaMissense.html
index 0810536..182f34b 100644
--- a/reference/AlphaMissense.html
+++ b/reference/AlphaMissense.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="ALPHAMISSENSE_RECORD is a constant identifier
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD"><meta name="description" content="ALPHAMISSENSE_RECORD is a constant identifier
 corresponding to the default version of the AlphaMissense
 resource to use.
 am_browse() opens a web browser at the Zenodo record
@@ -8,7 +8,7 @@
 record.
 am_data() retrieves a single key from the the
 AlpahMissense Zenodo site and parses the file into a DuckDB
-database."><title>Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD"><meta property="og:description" content="ALPHAMISSENSE_RECORD is a constant identifier
+database."><meta property="og:description" content="ALPHAMISSENSE_RECORD is a constant identifier
 corresponding to the default version of the AlphaMissense
 resource to use.
 am_browse() opens a web browser at the Zenodo record
@@ -17,57 +17,43 @@
 record.
 am_data() retrieves a single key from the the
 AlpahMissense Zenodo site and parses the file into a DuckDB
-database."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
-<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
-<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]--></head><body>
+database."></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
-    
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light" data-bs-theme="light"><div class="container">
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+    <nav class="navbar navbar-expand-lg fixed-top bg-light" data-bs-theme="light" aria-label="Site navigation"><div class="container">
+
     <a class="navbar-brand me-2" href="../index.html">AlphaMissenseR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.5</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
 
-    
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
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-      <ul class="navbar-nav me-auto"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
-</li>
+      <ul class="navbar-nav me-auto"><li class="active nav-item"><a class="nav-link" href="../reference/index.html">Reference</a></li>
 <li class="nav-item dropdown">
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-    <a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a>
-    <a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a>
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+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles"><li><a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a></li>
+  </ul></li>
+<li class="nav-item"><a class="nav-link" href="../news/index.html">Changelog</a></li>
+      </ul><ul class="navbar-nav"><li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json"></form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
       </ul></div>
 
-    
+
   </div>
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>Retrieve AlphaMissense Resources as DuckDB Databases</h1>
+
+      <h1>Retrieve AlphaMissense Resources as DuckDB Databases</h1>
       <small class="dont-index">Source: <a href="https://github.com/mtmorgan/AlphaMissenseR/blob/HEAD/R/AlphaMissense.R" class="external-link"><code>R/AlphaMissense.R</code></a></small>
       <div class="d-none name"><code>AlphaMissense.Rd</code></div>
     </div>
@@ -107,24 +93,26 @@ <h2 id="format">Format<a class="anchor" aria-label="anchor" href="#format"></a><
     </div>
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>record</dt>
+
+
+<dl><dt id="arg-record">record<a class="anchor" aria-label="anchor" href="#arg-record"></a></dt>
 <dd><p>character(1) Zenodo record for the AlphaMissense data
 resources.</p></dd>
 
 
-<dt>bfc</dt>
+<dt id="arg-bfc">bfc<a class="anchor" aria-label="anchor" href="#arg-bfc"></a></dt>
 <dd><p>an object returned by <code>BiocFileCache()</code> representing the
 location where downloaded files and the parsed database will be
 stored. The default is the 'global' BiocFileCache.</p></dd>
 
 
-<dt>key</dt>
+<dt id="arg-key">key<a class="anchor" aria-label="anchor" href="#arg-key"></a></dt>
 <dd><p>a character(1) 'key' from the result of
 <code>am_available()</code>, or a single row of the tibble returned by
 <code>am_available()</code>.</p></dd>
 
 
-<dt>as</dt>
+<dt id="arg-as">as<a class="anchor" aria-label="anchor" href="#arg-as"></a></dt>
 <dd><p>chracter(1) type of return value.</p><ul><li><p><code>"tbl"</code>: a dbplyr tbl representation of the database resource.</p></li>
 <li><p><code>"tsv"</code>: path to the tsv.gz file representing the resource and
 downloaded from Zenodo</p></li>
@@ -133,13 +121,9 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    
-
-<p><code>am_available()</code> returns a tibble with columns <code>key</code>,
+    <p><code>am_available()</code> returns a tibble with columns <code>key</code>,
 <code>size</code>, and <code>link</code>. The meaning of key must be determined with
 reference to the information at <code>am_browse()</code>.</p>
-
-
 <p><code>am_data()</code> returns a dbplyr (database) tibble
 represented the downloaded and parsed file. Fields in the
 database are as described on the Zenodo resource page.</p>
@@ -177,7 +161,7 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-in"><span></span></span>
 <span class="r-in"><span><span class="fu">am_data</span><span class="op">(</span><span class="st">"hg38"</span><span class="op">)</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Source:   table&lt;hg38&gt; [?? x 10]</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>  <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>      <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>             <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>          </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 1</span> chr1  <span style="text-decoration: underline;">69</span>094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L            </span>
@@ -198,7 +182,7 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-in"><span></span></span>
 </code></pre></div>
     </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside></div>
 
 
@@ -207,14 +191,14 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
 </div>
 
     </footer></div>
 
-  
 
-  
+
+
 
   </body></html>
 
diff --git a/reference/ClinVar.html b/reference/ClinVar.html
index 378cf84..7bba410 100644
--- a/reference/ClinVar.html
+++ b/reference/ClinVar.html
@@ -1,69 +1,55 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content='clinvar_data() loads ClinVar information from the
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data"><meta name="description" content='clinvar_data() loads ClinVar information from the
 supplemental table of the AlphaMissense
 [2023]
 paper.
 clinvar_plot() integrates ClinVar classifications
 with AlphaMissense predicted scores derived from
 am_data("aa_substitutions") and returns a ggplot object for
-visualization.'><title>Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data"><meta property="og:description" content='clinvar_data() loads ClinVar information from the
+visualization.'><meta property="og:description" content='clinvar_data() loads ClinVar information from the
 supplemental table of the AlphaMissense
 [2023]
 paper.
 clinvar_plot() integrates ClinVar classifications
 with AlphaMissense predicted scores derived from
 am_data("aa_substitutions") and returns a ggplot object for
-visualization.'><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
-<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
-<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]--></head><body>
+visualization.'></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
-    
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light" data-bs-theme="light"><div class="container">
-    
+
+    <nav class="navbar navbar-expand-lg fixed-top bg-light" data-bs-theme="light" aria-label="Site navigation"><div class="container">
+
     <a class="navbar-brand me-2" href="../index.html">AlphaMissenseR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.5</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
 
-    
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
       <span class="navbar-toggler-icon"></span>
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     <div id="navbar" class="collapse navbar-collapse ms-3">
-      <ul class="navbar-nav me-auto"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
-</li>
+      <ul class="navbar-nav me-auto"><li class="active nav-item"><a class="nav-link" href="../reference/index.html">Reference</a></li>
 <li class="nav-item dropdown">
-  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
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-    <a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a>
-    <a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a>
-    <a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a>
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-        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
-
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-  <a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="github">
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-     
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-</li>
+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles"><li><a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a></li>
+  </ul></li>
+<li class="nav-item"><a class="nav-link" href="../news/index.html">Changelog</a></li>
+      </ul><ul class="navbar-nav"><li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json"></form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
       </ul></div>
 
-    
+
   </div>
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores</h1>
+
+      <h1>Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores</h1>
       <small class="dont-index">Source: <a href="https://github.com/mtmorgan/AlphaMissenseR/blob/HEAD/R/ClinVar.R" class="external-link"><code>R/ClinVar.R</code></a></small>
       <div class="d-none name"><code>ClinVar.Rd</code></div>
     </div>
@@ -88,22 +74,24 @@ <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage">
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>record</dt>
+
+
+<dl><dt id="arg-record">record<a class="anchor" aria-label="anchor" href="#arg-record"></a></dt>
 <dd><p>character(1) Zenodo record for the AlphaMissense data
 resources.</p></dd>
 
 
-<dt>bfc</dt>
+<dt id="arg-bfc">bfc<a class="anchor" aria-label="anchor" href="#arg-bfc"></a></dt>
 <dd><p>an object returned by <code>BiocFileCache()</code> representing the
 location of the AlphaMissenseR database. The default is the
 'global' BiocFileCache.</p></dd>
 
 
-<dt>uniprotId</dt>
+<dt id="arg-uniprotid">uniprotId<a class="anchor" aria-label="anchor" href="#arg-uniprotid"></a></dt>
 <dd><p><code><a href="https://rdrr.io/r/base/character.html" class="external-link">character()</a></code> a valid UniProt accession identifier.</p></dd>
 
 
-<dt>alphamissense_table</dt>
+<dt id="arg-alphamissense-table">alphamissense_table<a class="anchor" aria-label="anchor" href="#arg-alphamissense-table"></a></dt>
 <dd><p>a table containing AlphaMissense
 predictions for protein variants. By default, the table is
 derived from <code>am_data("aa_substitution")</code>. Alternatively, a
@@ -111,7 +99,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 can be supplied.</p></dd>
 
 
-<dt>clinvar_table</dt>
+<dt id="arg-clinvar-table">clinvar_table<a class="anchor" aria-label="anchor" href="#arg-clinvar-table"></a></dt>
 <dd><p>a table containing ClinVar information. By
 default, the table is derived from the supplemental data of the
 AlphaMissense paper. Alternatively, a user-defined
@@ -121,9 +109,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    
-
-<p><code>clinvar_data()</code> returns a tbl with 82872 rows and 5 variables:</p><ul><li><p><code>variant_id</code>: ClinVar variant identifier.</p></li>
+    <p><code>clinvar_data()</code> returns a tbl with 82872 rows and 5 variables:</p><ul><li><p><code>variant_id</code>: ClinVar variant identifier.</p></li>
 <li><p><code>transcript_id</code>: Ensembl transcript identifier.</p></li>
 <li><p><code>protein_variant</code>: UniProt accession:protein variant identifier.</p></li>
 <li><p><code>AlphaMissense</code>: AlphaMissense pathogenicity score.</p></li>
@@ -162,7 +148,7 @@ <h2 id="references">References<a class="anchor" aria-label="anchor" href="#refer
     <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-examples"></a></h2>
     <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="fu">clinvar_data</span><span class="op">(</span><span class="op">)</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Source:   table&lt;clinvar&gt; [?? x 5]</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>    variant_id           transcript_id     protein_variant AlphaMissense label </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>                <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>             <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>                   <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span> <span style="color: #949494; font-style: italic;">&lt;fct&gt;</span> </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 1</span> chr1_925969_C_T_hg38 ENST00000342066.8 Q96NU1:P10S            0.967  benign</span>
@@ -183,12 +169,12 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-in"><span>    uniprotId <span class="op">=</span> <span class="st">"P37023"</span>,</span></span>
 <span class="r-in"><span>    alphamissense_table <span class="op">=</span> <span class="va">alphamissense_table</span></span></span>
 <span class="r-in"><span><span class="op">)</span></span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> * [14:04:41][info] 'clinvar_table' not provided, using default ClinVar dataset in AlphaMissenseR package</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> * [11:38:21][info] 'clinvar_table' not provided, using default ClinVar dataset in AlphaMissenseR package</span>
 <span class="r-plt img"><img src="ClinVar-1.png" alt="" width="700" height="433"></span>
 <span class="r-in"><span></span></span>
 </code></pre></div>
     </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside></div>
 
 
@@ -197,14 +183,14 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
 </div>
 
     </footer></div>
 
-  
 
-  
+
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   </body></html>
 
diff --git a/reference/GenomicRanges.html b/reference/GenomicRanges.html
index ad8b914..e0bef95 100644
--- a/reference/GenomicRanges.html
+++ b/reference/GenomicRanges.html
@@ -1,59 +1,45 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content='to_GPos() coerces a tibble derived from
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos"><meta name="description" content='to_GPos() coerces a tibble derived from
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+GenomicRanges GPos objects.'><meta property="og:description" content='to_GPos() coerces a tibble derived from
 am_data("hg19") or am_data("hg38") resources to
-GenomicRanges GPos objects.'><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
-<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
-<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]--></head><body>
+GenomicRanges GPos objects.'></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
-    
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light" data-bs-theme="light"><div class="container">
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+    <nav class="navbar navbar-expand-lg fixed-top bg-light" data-bs-theme="light" aria-label="Site navigation"><div class="container">
+
     <a class="navbar-brand me-2" href="../index.html">AlphaMissenseR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.5</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
 
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-</li>
+      <ul class="navbar-nav me-auto"><li class="active nav-item"><a class="nav-link" href="../reference/index.html">Reference</a></li>
 <li class="nav-item dropdown">
-  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
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-    <a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a>
-    <a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a>
-    <a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a>
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+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles"><li><a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a></li>
+  </ul></li>
+<li class="nav-item"><a class="nav-link" href="../news/index.html">Changelog</a></li>
+      </ul><ul class="navbar-nav"><li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json"></form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
       </ul></div>
 
-    
+
   </div>
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>Create GenomicRanges Objects from AlphaMissense Annotations</h1>
+
+      <h1>Create GenomicRanges Objects from AlphaMissense Annotations</h1>
       <small class="dont-index">Source: <a href="https://github.com/mtmorgan/AlphaMissenseR/blob/HEAD/R/GenomicRanges.R" class="external-link"><code>R/GenomicRanges.R</code></a></small>
       <div class="d-none name"><code>GenomicRanges.Rd</code></div>
     </div>
@@ -71,7 +57,9 @@ <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage">
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>tbl</dt>
+
+
+<dl><dt id="arg-tbl">tbl<a class="anchor" aria-label="anchor" href="#arg-tbl"></a></dt>
 <dd><p>a tibble derived from <code>am_data("hg19")</code> or
 <code>am_data("hg38")</code>. The tibble must have columns <code>CHROM</code>, <code>POS</code>,
 and <code>genome</code>.</p></dd>
@@ -79,9 +67,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    
-
-<p><code>to_GPos()</code> returns a <code>GPos</code> object, which can be used in
+    <p><code>to_GPos()</code> returns a <code>GPos</code> object, which can be used in
 the same was a <code>GRanges</code> object for range-based filtering and
 annotation</p>
     </div>
@@ -89,8 +75,8 @@ <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2
     <div class="section level2">
     <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-examples"></a></h2>
     <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="fu"><a href="AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"hg38"</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
-<span class="r-in"><span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">CHROM</span> <span class="op">==</span> <span class="st">"chr2"</span>, <span class="va">POS</span> <span class="op">&lt;</span> <span class="fl">10000000</span>, <span class="va">REF</span> <span class="op">==</span> <span class="st">"G"</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
-<span class="r-in"><span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/select.html" class="external-link">select</a></span><span class="op">(</span><span class="op">-</span><span class="va">REF</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
+<span class="r-in"><span>    <span class="fu"><a href="https://rdrr.io/r/stats/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">CHROM</span> <span class="op">==</span> <span class="st">"chr2"</span>, <span class="va">POS</span> <span class="op">&lt;</span> <span class="fl">10000000</span>, <span class="va">REF</span> <span class="op">==</span> <span class="st">"G"</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
+<span class="r-in"><span>    <span class="fu">select</span><span class="op">(</span><span class="op">-</span><span class="va">REF</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
 <span class="r-in"><span>    <span class="fu">to_GPos</span><span class="op">(</span><span class="op">)</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> UnstitchedGPos object with 26751 positions and 6 metadata columns:</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>           seqnames       pos strand |         ALT  uniprot_id</span>
@@ -124,7 +110,7 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-in"><span></span></span>
 </code></pre></div>
     </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside></div>
 
 
@@ -133,14 +119,14 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
 </div>
 
     </footer></div>
 
-  
 
-  
+
+
 
   </body></html>
 
diff --git a/reference/Gosling.html b/reference/Gosling.html
new file mode 100644
index 0000000..65d5590
--- /dev/null
+++ b/reference/Gosling.html
@@ -0,0 +1,159 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Plot a GPos or GRanges Object Using Shiny and Gosling — gosling_plot • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Plot a GPos or GRanges Object Using Shiny and Gosling — gosling_plot"><meta name="description" content="plot_granges() creates a Shiny app that displays a
+Gosling plot of a given GRanges object.  It visualizes genomic
+ranges with both rectangle and point representations, and
+allows for customization of the plot title and subtitle."><meta property="og:description" content="plot_granges() creates a Shiny app that displays a
+Gosling plot of a given GRanges object.  It visualizes genomic
+ranges with both rectangle and point representations, and
+allows for customization of the plot title and subtitle."></head><body>
+    <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
+
+
+    <nav class="navbar navbar-expand-lg fixed-top bg-light" data-bs-theme="light" aria-label="Site navigation"><div class="container">
+
+    <a class="navbar-brand me-2" href="../index.html">AlphaMissenseR</a>
+
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
+
+    <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
+      <span class="navbar-toggler-icon"></span>
+    </button>
+
+    <div id="navbar" class="collapse navbar-collapse ms-3">
+      <ul class="navbar-nav me-auto"><li class="active nav-item"><a class="nav-link" href="../reference/index.html">Reference</a></li>
+<li class="nav-item dropdown">
+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles"><li><a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a></li>
+  </ul></li>
+<li class="nav-item"><a class="nav-link" href="../news/index.html">Changelog</a></li>
+      </ul><ul class="navbar-nav"><li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json"></form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
+      </ul></div>
+
+
+  </div>
+</nav><div class="container template-reference-topic">
+<div class="row">
+  <main id="main" class="col-md-9"><div class="page-header">
+
+      <h1>Plot a GPos or GRanges Object Using Shiny and Gosling</h1>
+      <small class="dont-index">Source: <a href="https://github.com/mtmorgan/AlphaMissenseR/blob/HEAD/R/Gosling.R" class="external-link"><code>R/Gosling.R</code></a></small>
+      <div class="d-none name"><code>Gosling.Rd</code></div>
+    </div>
+
+    <div class="ref-description section level2">
+    <p><code>plot_granges()</code> creates a Shiny app that displays a
+Gosling plot of a given GRanges object.  It visualizes genomic
+ranges with both rectangle and point representations, and
+allows for customization of the plot title and subtitle.</p>
+    </div>
+
+    <div class="section level2">
+    <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage"></a></h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span><span class="fu">gosling_plot</span><span class="op">(</span></span>
+<span>  <span class="va">granges</span>,</span>
+<span>  title <span class="op">=</span> <span class="st">"GRanges Plot"</span>,</span>
+<span>  subtitle <span class="op">=</span> <span class="st">"Stacked nucleotide example"</span>,</span>
+<span>  plot_type <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"bar"</span>, <span class="st">"lollipop"</span><span class="op">)</span>,</span>
+<span>  create_app <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/interactive.html" class="external-link">interactive</a></span><span class="op">(</span><span class="op">)</span></span>
+<span><span class="op">)</span></span></code></pre></div>
+    </div>
+
+    <div class="section level2">
+    <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
+
+
+<dl><dt id="arg-granges">granges<a class="anchor" aria-label="anchor" href="#arg-granges"></a></dt>
+<dd><p>A <code><a href="https://rdrr.io/pkg/GenomicRanges/man/GRanges-class.html" class="external-link">GenomicRanges::GRanges</a></code> (e.g.,
+<code><a href="https://rdrr.io/pkg/GenomicRanges/man/GPos-class.html" class="external-link">GenomicRanges::GPos</a></code>) object containing the genomic ranges
+to be plotted.</p></dd>
+
+
+<dt id="arg-title">title<a class="anchor" aria-label="anchor" href="#arg-title"></a></dt>
+<dd><p>character(1) Title of the plot. Default is
+"GRanges Plot".</p></dd>
+
+
+<dt id="arg-subtitle">subtitle<a class="anchor" aria-label="anchor" href="#arg-subtitle"></a></dt>
+<dd><p>character(1) The subtitle of the plot. Default is
+"Stacked nucleotide example".</p></dd>
+
+
+<dt id="arg-plot-type">plot_type<a class="anchor" aria-label="anchor" href="#arg-plot-type"></a></dt>
+<dd><p>character(1) Select the type of gosling plot.
+Default is "bar"; available types are described in Details.</p></dd>
+
+
+<dt id="arg-create-app">create_app<a class="anchor" aria-label="anchor" href="#arg-create-app"></a></dt>
+<dd><p>logical(1) Produce a Shiny app for Gosling
+visualization. Default <code>TRUE</code> when used interactively.</p></dd>
+
+</dl></div>
+    <div class="section level2">
+    <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
+    <p><code>gosling_plot()</code> with <code>create_app = TRUE</code> returns a
+<code>shinyApp</code> object that, when run, displays the Gosling
+plot. When <code>create_app = FALSE</code>, the (invisible) return value
+represents the gosling object to be used in Shiny apps.</p>
+    </div>
+    <div class="section level2">
+    <h2 id="details">Details<a class="anchor" aria-label="anchor" href="#details"></a></h2>
+    <p>The function supports 2 types of plots as selected through the
+<code>plot_type</code> argument: (1) <code>"bar"</code>: a barplot-like view of the
+pathogenicity score at each position, similar to a sequencing
+coverage plot, and (2) <code>"lollipop"</code>: a lollipop plot focusing on
+the pathogenicity classification (ambiguous, benign, pathogenic) at
+each position. It requires that the <code><a href="https://rdrr.io/pkg/GenomicRanges/man/GRanges-class.html" class="external-link">GenomicRanges::GRanges</a></code>
+object has the following metadata columns: 'am_class' (effect
+classification),'am_pathogenicity' (pathogenicity score), 'ALT'
+(alternative allele) and 'REF' (reference allele).</p>
+    </div>
+    <div class="section level2">
+    <h2 id="note">Note<a class="anchor" aria-label="anchor" href="#note"></a></h2>
+    <p>This function requires the <code>shiny</code>, <code>shiny.gosling</code>, and
+<code>GenomicRanges</code> packages to be installed.</p>
+    </div>
+
+    <div class="section level2">
+    <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-examples"></a></h2>
+    <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span><span class="co">## Create a sample GRanges object from AlphamissenseR</span></span></span>
+<span class="r-in"><span><span class="va">gpos</span> <span class="op">&lt;-</span></span></span>
+<span class="r-in"><span>    <span class="fu"><a href="AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"hg38"</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
+<span class="r-in"><span>    <span class="fu"><a href="https://rdrr.io/r/stats/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">uniprot_id</span> <span class="op">==</span> <span class="st">"Q1W6H9"</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
+<span class="r-in"><span>    <span class="fu"><a href="GenomicRanges.html">to_GPos</a></span><span class="op">(</span><span class="op">)</span></span></span>
+<span class="r-in"><span></span></span>
+<span class="r-in"><span><span class="co">## Plot `gpos` using shiny.gosling</span></span></span>
+<span class="r-in"><span><span class="kw">if</span> <span class="op">(</span><span class="fu"><a href="https://rdrr.io/r/base/ns-load.html" class="external-link">requireNamespace</a></span><span class="op">(</span><span class="st">"shiny.gosling"</span>, quietly <span class="op">=</span> <span class="cn">TRUE</span><span class="op">)</span><span class="op">)</span> <span class="op">{</span></span></span>
+<span class="r-in"><span>   <span class="fu">gosling_plot</span><span class="op">(</span></span></span>
+<span class="r-in"><span>       <span class="va">gpos</span>, title <span class="op">=</span> <span class="st">"Q1W6H_track"</span>, subtitle <span class="op">=</span> <span class="st">"bar plot example"</span>,</span></span>
+<span class="r-in"><span>       plot_type <span class="op">=</span> <span class="st">"bar"</span>, create_app <span class="op">=</span> <span class="cn">FALSE</span></span></span>
+<span class="r-in"><span>   <span class="op">)</span></span></span>
+<span class="r-in"><span><span class="op">}</span></span></span>
+<span class="r-in"><span></span></span>
+</code></pre></div>
+    </div>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
+    </nav></aside></div>
+
+
+    <footer><div class="pkgdown-footer-left">
+  <p>Developed by Martin Morgan, Tram Nguyen, Chan Zuckerberg Initiative DAF CZF2019-002443, NIH NCI ITCR U24CA180996, NIH NCI IOTN U24CA232979, NIH NCI ARTNet U24CA274159.</p>
+</div>
+
+<div class="pkgdown-footer-right">
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
+</div>
+
+    </footer></div>
+
+
+
+
+
+  </body></html>
+
diff --git a/reference/af_colorfunc_by_position.html b/reference/af_colorfunc_by_position.html
new file mode 100644
index 0000000..91b0240
--- /dev/null
+++ b/reference/af_colorfunc_by_position.html
@@ -0,0 +1,8 @@
+<html>
+  <head>
+    <meta http-equiv="refresh" content="0;URL=https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html" />
+    <meta name="robots" content="noindex">
+    <link rel="canonical" href="https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html">
+  </head>
+</html>
+
diff --git a/reference/af_prediction_view.html b/reference/af_prediction_view.html
new file mode 100644
index 0000000..91b0240
--- /dev/null
+++ b/reference/af_prediction_view.html
@@ -0,0 +1,8 @@
+<html>
+  <head>
+    <meta http-equiv="refresh" content="0;URL=https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html" />
+    <meta name="robots" content="noindex">
+    <link rel="canonical" href="https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html">
+  </head>
+</html>
+
diff --git a/reference/am_aa.html b/reference/am_aa.html
index 8c23ed8..9be0275 100644
--- a/reference/am_aa.html
+++ b/reference/am_aa.html
@@ -1,61 +1,47 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="am_aa_pos() separates protein_variant columns into
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Common Amino Acid-level Transformations — am_aa_pos • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Common Amino Acid-level Transformations — am_aa_pos"><meta name="description" content="am_aa_pos() separates protein_variant columns into
 amino acide 'pos', 'ref', and 'alt' columns.
 am_aa_pathogenicity() summarizes pathogenicity
-scores at each protein amino acid position."><title>Common Amino Acid-level Transformations — am_aa_pos • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Common Amino Acid-level Transformations — am_aa_pos"><meta property="og:description" content="am_aa_pos() separates protein_variant columns into
+scores at each protein amino acid position."><meta property="og:description" content="am_aa_pos() separates protein_variant columns into
 amino acide 'pos', 'ref', and 'alt' columns.
 am_aa_pathogenicity() summarizes pathogenicity
-scores at each protein amino acid position."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
-<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
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-<![endif]--></head><body>
+scores at each protein amino acid position."></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
-    
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light" data-bs-theme="light"><div class="container">
-    
+
+    <nav class="navbar navbar-expand-lg fixed-top bg-light" data-bs-theme="light" aria-label="Site navigation"><div class="container">
+
     <a class="navbar-brand me-2" href="../index.html">AlphaMissenseR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.5</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
 
-    
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
       <span class="navbar-toggler-icon"></span>
     </button>
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
-      <ul class="navbar-nav me-auto"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
-</li>
+      <ul class="navbar-nav me-auto"><li class="active nav-item"><a class="nav-link" href="../reference/index.html">Reference</a></li>
 <li class="nav-item dropdown">
-  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
-  <div class="dropdown-menu" aria-labelledby="dropdown-articles">
-    <a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a>
-    <a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a>
-    <a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a>
-    <a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a>
-  </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../news/index.html">Changelog</a>
-</li>
-      </ul><form class="form-inline my-2 my-lg-0" role="search">
-        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
-
-      <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="github">
-    <span class="fab fa fab fa-github fa-lg"></span>
-     
-  </a>
-</li>
+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles"><li><a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a></li>
+  </ul></li>
+<li class="nav-item"><a class="nav-link" href="../news/index.html">Changelog</a></li>
+      </ul><ul class="navbar-nav"><li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json"></form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
       </ul></div>
 
-    
+
   </div>
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>Common Amino Acid-level Transformations</h1>
+
+      <h1>Common Amino Acid-level Transformations</h1>
       <small class="dont-index">Source: <a href="https://github.com/mtmorgan/AlphaMissenseR/blob/HEAD/R/am_aa.R" class="external-link"><code>R/am_aa.R</code></a></small>
       <div class="d-none name"><code>am_aa.Rd</code></div>
     </div>
@@ -76,7 +62,9 @@ <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage">
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>tbl</dt>
+
+
+<dl><dt id="arg-tbl">tbl<a class="anchor" aria-label="anchor" href="#arg-tbl"></a></dt>
 <dd><p>a tibble, usually derived from
 <code>am_data("aa_substitutions")</code>, `am_data("hg38"), etc. See
 details.</p></dd>
@@ -84,9 +72,7 @@ <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#argumen
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    
-
-<p><code>am_aa_pos()</code> returns the original table with additional columns</p><ul><li><p><code>aa_pos</code>: the position of the protein variant,
+    <p><code>am_aa_pos()</code> returns the original table with additional columns</p><ul><li><p><code>aa_pos</code>: the position of the protein variant,
 as an <code><a href="https://rdrr.io/r/base/integer.html" class="external-link">integer()</a></code>.</p></li>
 <li><p><code>aa_ref</code>: the single-character reference amino acid in the
 protein variant.</p></li>
@@ -104,7 +90,7 @@ <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2
 </ul></div>
     <div class="section level2">
     <h2 id="details">Details<a class="anchor" aria-label="anchor" href="#details"></a></h2>
-    <p><code>tbl</code> is <code><a href="https://dplyr.tidyverse.org/reference/compute.html" class="external-link">collect()</a></code>ed before computation, so all rows must fit
+    <p><code>tbl</code> is <code>collect()</code>ed before computation, so all rows must fit
 into memory.</p>
 <p>For <code>am_aa_pos()</code>, <code>tbl</code> must contain a column <code>protein_variant</code>
 with entries in the form <code>"Q465H"</code>, as in the AlphaMissense data.</p>
@@ -119,7 +105,7 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
     <div class="sourceCode"><pre class="sourceCode r"><code><span class="r-in"><span></span></span>
 <span class="r-in"><span><span class="va">P35557</span> <span class="op">&lt;-</span></span></span>
 <span class="r-in"><span>    <span class="fu"><a href="AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"hg38"</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
-<span class="r-in"><span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">uniprot_id</span> <span class="op"><a href="https://rdrr.io/r/base/match.html" class="external-link">%in%</a></span> <span class="st">"P35557"</span><span class="op">)</span></span></span>
+<span class="r-in"><span>    <span class="fu"><a href="https://rdrr.io/r/stats/filter.html" class="external-link">filter</a></span><span class="op">(</span><span class="va">uniprot_id</span> <span class="op"><a href="https://rdrr.io/r/base/match.html" class="external-link">%in%</a></span> <span class="st">"P35557"</span><span class="op">)</span></span></span>
 <span class="r-in"><span></span></span>
 <span class="r-in"><span><span class="fu">am_aa_pos</span><span class="op">(</span><span class="va">P35557</span><span class="op">)</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># A tibble: 3,085 × 13</span></span>
@@ -140,11 +126,11 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;">#   aa_ref &lt;chr&gt;, aa_alt &lt;chr&gt;</span></span>
 <span class="r-in"><span></span></span>
 <span class="r-in"><span><span class="fu">am_aa_pos</span><span class="op">(</span><span class="va">P35557</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
-<span class="r-in"><span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/select.html" class="external-link">select</a></span><span class="op">(</span></span></span>
+<span class="r-in"><span>    <span class="fu">select</span><span class="op">(</span></span></span>
 <span class="r-in"><span>        <span class="va">uniprot_id</span>, <span class="va">POS</span>, <span class="va">REF</span>, <span class="va">ALT</span>, <span class="va">protein_variant</span>,</span></span>
-<span class="r-in"><span>        <span class="fu"><a href="https://tidyselect.r-lib.org/reference/starts_with.html" class="external-link">starts_with</a></span><span class="op">(</span><span class="st">"aa_"</span><span class="op">)</span>, <span class="va">am_pathogenicity</span>, <span class="va">am_class</span></span></span>
+<span class="r-in"><span>        <span class="fu">starts_with</span><span class="op">(</span><span class="st">"aa_"</span><span class="op">)</span>, <span class="va">am_pathogenicity</span>, <span class="va">am_class</span></span></span>
 <span class="r-in"><span>    <span class="op">)</span> <span class="op">|&gt;</span></span></span>
-<span class="r-in"><span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/arrange.html" class="external-link">arrange</a></span><span class="op">(</span><span class="va">aa_pos</span><span class="op">)</span></span></span>
+<span class="r-in"><span>    <span class="fu">arrange</span><span class="op">(</span><span class="va">aa_pos</span><span class="op">)</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># A tibble: 3,085 × 10</span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>    uniprot_id      POS REF   ALT   protein_variant aa_pos aa_ref aa_alt</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>         <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>            <span style="color: #949494; font-style: italic;">&lt;int&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>  <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> </span>
@@ -183,7 +169,7 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-in"><span></span></span>
 </code></pre></div>
     </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside></div>
 
 
@@ -192,14 +178,14 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
 </div>
 
     </footer></div>
 
-  
 
-  
+
+
 
   </body></html>
 
diff --git a/reference/am_aa_pathogenicity.html b/reference/am_aa_pathogenicity.html
new file mode 100644
index 0000000..22e4152
--- /dev/null
+++ b/reference/am_aa_pathogenicity.html
@@ -0,0 +1,8 @@
+<html>
+  <head>
+    <meta http-equiv="refresh" content="0;URL=https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html" />
+    <meta name="robots" content="noindex">
+    <link rel="canonical" href="https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html">
+  </head>
+</html>
+
diff --git a/reference/am_available.html b/reference/am_available.html
new file mode 100644
index 0000000..596e341
--- /dev/null
+++ b/reference/am_available.html
@@ -0,0 +1,8 @@
+<html>
+  <head>
+    <meta http-equiv="refresh" content="0;URL=https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html" />
+    <meta name="robots" content="noindex">
+    <link rel="canonical" href="https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html">
+  </head>
+</html>
+
diff --git a/reference/am_browse.html b/reference/am_browse.html
new file mode 100644
index 0000000..596e341
--- /dev/null
+++ b/reference/am_browse.html
@@ -0,0 +1,8 @@
+<html>
+  <head>
+    <meta http-equiv="refresh" content="0;URL=https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html" />
+    <meta name="robots" content="noindex">
+    <link rel="canonical" href="https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html">
+  </head>
+</html>
+
diff --git a/reference/am_data.html b/reference/am_data.html
new file mode 100644
index 0000000..596e341
--- /dev/null
+++ b/reference/am_data.html
@@ -0,0 +1,8 @@
+<html>
+  <head>
+    <meta http-equiv="refresh" content="0;URL=https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html" />
+    <meta name="robots" content="noindex">
+    <link rel="canonical" href="https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html">
+  </head>
+</html>
+
diff --git a/reference/clinvar_plot.html b/reference/clinvar_plot.html
new file mode 100644
index 0000000..82068e5
--- /dev/null
+++ b/reference/clinvar_plot.html
@@ -0,0 +1,8 @@
+<html>
+  <head>
+    <meta http-equiv="refresh" content="0;URL=https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html" />
+    <meta name="robots" content="noindex">
+    <link rel="canonical" href="https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html">
+  </head>
+</html>
+
diff --git a/reference/db.html b/reference/db.html
index 905035b..85dca9b 100644
--- a/reference/db.html
+++ b/reference/db.html
@@ -1,5 +1,5 @@
 <!DOCTYPE html>
-<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><meta name="description" content="db_connect() manages connections to AlphaMissense
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en"><head><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta charset="utf-8"><meta http-equiv="X-UA-Compatible" content="IE=edge"><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><title>Manipulate the Database of Missense Mutations — db_connect • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><link href="../deps/font-awesome-6.4.2/css/all.min.css" rel="stylesheet"><link href="../deps/font-awesome-6.4.2/css/v4-shims.min.css" rel="stylesheet"><script src="../deps/headroom-0.11.0/headroom.min.js"></script><script src="../deps/headroom-0.11.0/jQuery.headroom.min.js"></script><script src="../deps/bootstrap-toc-1.0.1/bootstrap-toc.min.js"></script><script src="../deps/clipboard.js-2.0.11/clipboard.min.js"></script><script src="../deps/search-1.0.0/autocomplete.jquery.min.js"></script><script src="../deps/search-1.0.0/fuse.min.js"></script><script src="../deps/search-1.0.0/mark.min.js"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Manipulate the Database of Missense Mutations — db_connect"><meta name="description" content="db_connect() manages connections to AlphaMissense
 record-specific databases. By default, connections are created
 once and reused.
 db_tables() queries for the names of temporary and
@@ -13,7 +13,7 @@
 shuts down the DuckDB server associated with the
 connection. Temporary tables are lost.
 db_disconnect_all() disconnects all managed duckdb
-database connection."><title>Manipulate the Database of Missense Mutations — db_connect • AlphaMissenseR</title><script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"><link href="../deps/bootstrap-5.3.1/bootstrap.min.css" rel="stylesheet"><script src="../deps/bootstrap-5.3.1/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous"><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous"><!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.11/clipboard.min.js" integrity="sha512-7O5pXpc0oCRrxk8RUfDYFgn0nO1t+jLuIOQdOMRp4APB7uZ4vSjspzp5y6YDtDs4VzUSTbWzBFZ/LKJhnyFOKw==" crossorigin="anonymous" referrerpolicy="no-referrer"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Manipulate the Database of Missense Mutations — db_connect"><meta property="og:description" content="db_connect() manages connections to AlphaMissense
+database connection."><meta property="og:description" content="db_connect() manages connections to AlphaMissense
 record-specific databases. By default, connections are created
 once and reused.
 db_tables() queries for the names of temporary and
@@ -27,57 +27,43 @@
 shuts down the DuckDB server associated with the
 connection. Temporary tables are lost.
 db_disconnect_all() disconnects all managed duckdb
-database connection."><!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
-<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
-<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
-<![endif]--></head><body>
+database connection."></head><body>
     <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
-    
 
-    <nav class="navbar fixed-top navbar-light navbar-expand-lg bg-light" data-bs-theme="light"><div class="container">
-    
+
+    <nav class="navbar navbar-expand-lg fixed-top bg-light" data-bs-theme="light" aria-label="Site navigation"><div class="container">
+
     <a class="navbar-brand me-2" href="../index.html">AlphaMissenseR</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.5</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">1.1.6</small>
+
 
-    
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
       <span class="navbar-toggler-icon"></span>
     </button>
 
     <div id="navbar" class="collapse navbar-collapse ms-3">
-      <ul class="navbar-nav me-auto"><li class="active nav-item">
-  <a class="nav-link" href="../reference/index.html">Reference</a>
-</li>
+      <ul class="navbar-nav me-auto"><li class="active nav-item"><a class="nav-link" href="../reference/index.html">Reference</a></li>
 <li class="nav-item dropdown">
-  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-articles">Articles</a>
-  <div class="dropdown-menu" aria-labelledby="dropdown-articles">
-    <a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a>
-    <a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a>
-    <a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a>
-    <a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a>
-  </div>
-</li>
-<li class="nav-item">
-  <a class="nav-link" href="../news/index.html">Changelog</a>
-</li>
-      </ul><form class="form-inline my-2 my-lg-0" role="search">
-        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
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-      <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="github">
-    <span class="fab fa fab fa-github fa-lg"></span>
-     
-  </a>
-</li>
+  <button class="nav-link dropdown-toggle" type="button" id="dropdown-articles" data-bs-toggle="dropdown" aria-expanded="false" aria-haspopup="true">Articles</button>
+  <ul class="dropdown-menu" aria-labelledby="dropdown-articles"><li><a class="dropdown-item" href="../articles/introduction.html">A. Introduction</a></li>
+    <li><a class="dropdown-item" href="../articles/alphafold.html">B. AlphaFold Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/clinvar.html">C. ClinVar Integration</a></li>
+    <li><a class="dropdown-item" href="../articles/issues.html">D. Issues &amp; Solutions</a></li>
+  </ul></li>
+<li class="nav-item"><a class="nav-link" href="../news/index.html">Changelog</a></li>
+      </ul><ul class="navbar-nav"><li class="nav-item"><form class="form-inline" role="search">
+ <input class="form-control" type="search" name="search-input" id="search-input" autocomplete="off" aria-label="Search site" placeholder="Search for" data-search-index="../search.json"></form></li>
+<li class="nav-item"><a class="external-link nav-link" href="https://github.com/mtmorgan/AlphaMissenseR/" aria-label="GitHub"><span class="fa fab fa-github fa-lg"></span></a></li>
       </ul></div>
 
-    
+
   </div>
 </nav><div class="container template-reference-topic">
 <div class="row">
   <main id="main" class="col-md-9"><div class="page-header">
-      <img src="" class="logo" alt=""><h1>Manipulate the Database of Missense Mutations</h1>
+
+      <h1>Manipulate the Database of Missense Mutations</h1>
       <small class="dont-index">Source: <a href="https://github.com/mtmorgan/AlphaMissenseR/blob/HEAD/R/db.R" class="external-link"><code>R/db.R</code></a></small>
       <div class="d-none name"><code>db.Rd</code></div>
     </div>
@@ -122,78 +108,68 @@ <h2 id="ref-usage">Usage<a class="anchor" aria-label="anchor" href="#ref-usage">
 
     <div class="section level2">
     <h2 id="arguments">Arguments<a class="anchor" aria-label="anchor" href="#arguments"></a></h2>
-    <dl><dt>record</dt>
+
+
+<dl><dt id="arg-record">record<a class="anchor" aria-label="anchor" href="#arg-record"></a></dt>
 <dd><p>character(1) Zenodo record for the AlphaMissense data
 resources.</p></dd>
 
 
-<dt>bfc</dt>
+<dt id="arg-bfc">bfc<a class="anchor" aria-label="anchor" href="#arg-bfc"></a></dt>
 <dd><p>an object returned by <code>BiocFileCache()</code> representing the
 location where downloaded files and the parsed database will be
 stored. The default is the 'global' BiocFileCache.</p></dd>
 
 
-<dt>read_only</dt>
+<dt id="arg-read-only">read_only<a class="anchor" aria-label="anchor" href="#arg-read-only"></a></dt>
 <dd><p>logical(1) open the connection 'read only'.
 <code>TRUE</code> protects against overwriting existing data and is the
 default.</p></dd>
 
 
-<dt>managed</dt>
+<dt id="arg-managed">managed<a class="anchor" aria-label="anchor" href="#arg-managed"></a></dt>
 <dd><p>logical(1) when <code>TRUE</code>, re-use an existing managed
 connection to the same database.</p></dd>
 
 
-<dt>db</dt>
+<dt id="arg-db">db<a class="anchor" aria-label="anchor" href="#arg-db"></a></dt>
 <dd><p><code>duckdb_connection</code> object, returned by <code>db_connect()</code>.</p></dd>
 
 
-<dt>value</dt>
+<dt id="arg-value">value<a class="anchor" aria-label="anchor" href="#arg-value"></a></dt>
 <dd><p>a <code>data.frame</code> / <code>tibble</code> containing data to be placed
 in a temporary table, e.g., from a GenomicRanges object to be
 used in a range join.</p></dd>
 
 
-<dt>to</dt>
+<dt id="arg-to">to<a class="anchor" aria-label="anchor" href="#arg-to"></a></dt>
 <dd><p>the character(1) name of the table to be created</p></dd>
 
 
-<dt>key</dt>
+<dt id="arg-key">key<a class="anchor" aria-label="anchor" href="#arg-key"></a></dt>
 <dd><p>a character(1) table name in <code>db</code> containing missense
 mutation coordinates.</p></dd>
 
 
-<dt>join</dt>
+<dt id="arg-join">join<a class="anchor" aria-label="anchor" href="#arg-join"></a></dt>
 <dd><p>a character(1) table name in <code>db</code> containing ranges to
 be used for joining with (filtering) <code>key</code>.</p></dd>
 
 </dl></div>
     <div class="section level2">
     <h2 id="value">Value<a class="anchor" aria-label="anchor" href="#value"></a></h2>
-    
-
-<p><code>db_connect()</code> returns an open <code>duckdb_connection</code> to the
+    <p><code>db_connect()</code> returns an open <code>duckdb_connection</code> to the
 AlphaMissense record-specific database.</p>
-
-
 <p><code>db_tables()</code> returns a character vector of database table
 names.</p>
-
-
 <p><code>db_temporary_table()</code> returns the temporary table as a
 dbplyr <code>tibble</code>.</p>
-
-
 <p><code>db_range_join()</code> returns <code>to</code> (the temporary table created
 from the join) as a dbplyr tibble.</p>
-
-
 <p><code>db_disconnect()</code> returns <code>FALSE</code> if the connection has
 already been closed or is not valid (via <code>dbIsValid()</code>) or
 <code>TRUE</code> if disconnection is successful. Values are returned
 invisibly.</p>
-
-
 <p><code>db_disconnect_all()</code> returns the <code>db_disconnect()</code> value
 for each connection, invisibly.</p>
     </div>
@@ -231,7 +207,7 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-in"><span></span></span>
 <span class="r-in"><span><span class="fu"><a href="AlphaMissense.html">am_data</a></span><span class="op">(</span><span class="st">"hg38"</span><span class="op">)</span>       <span class="co"># uses the default, 'read-only' connection</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Source:   table&lt;hg38&gt; [?? x 10]</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>  <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>      <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>             <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>          </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 1</span> chr1  <span style="text-decoration: underline;">69</span>094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L            </span>
@@ -252,14 +228,14 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-out co"><span class="r-pr">#&gt;</span> [1] "aa_substitutions" "clinvar"          "gene_hg38"        "hg38"            </span>
 <span class="r-in"><span></span></span>
 <span class="r-in"><span><span class="co">## ranges of interest -- the first 200000 bases on chromsomes 1-4.</span></span></span>
-<span class="r-in"><span><span class="va">ranges</span> <span class="op">&lt;-</span> <span class="fu"><a href="https://tibble.tidyverse.org/reference/tibble.html" class="external-link">tibble</a></span><span class="op">(</span></span></span>
+<span class="r-in"><span><span class="va">ranges</span> <span class="op">&lt;-</span> <span class="fu">tibble</span><span class="op">(</span></span></span>
 <span class="r-in"><span>    CHROM <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/paste.html" class="external-link">paste0</a></span><span class="op">(</span><span class="st">"chr"</span>, <span class="fl">1</span><span class="op">:</span><span class="fl">4</span><span class="op">)</span>,</span></span>
 <span class="r-in"><span>    start <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="fl">1</span>, <span class="fl">4</span><span class="op">)</span>,</span></span>
 <span class="r-in"><span>    end <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/rep.html" class="external-link">rep</a></span><span class="op">(</span><span class="fl">200000</span>, <span class="fl">4</span><span class="op">)</span></span></span>
 <span class="r-in"><span><span class="op">)</span></span></span>
 <span class="r-in"><span><span class="fu">db_temporary_table</span><span class="op">(</span><span class="va">db_rw</span>, <span class="va">ranges</span>, <span class="st">"ranges"</span><span class="op">)</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Source:   table&lt;ranges&gt; [4 x 3]</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>   CHROM start    end</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>   <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span>  <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;">1</span> chr1      1 <span style="text-decoration: underline;">200</span>000</span>
@@ -276,27 +252,27 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-in"><span><span class="va">rng</span> <span class="op">&lt;-</span> <span class="fu">db_range_join</span><span class="op">(</span><span class="va">db_rw</span>, <span class="st">"hg38"</span>, <span class="st">"ranges"</span>, <span class="st">"ranges_overlaps"</span><span class="op">)</span></span></span>
 <span class="r-in"><span><span class="va">rng</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Source:   table&lt;ranges_overlaps&gt; [?? x 12]</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant</span>
-<span class="r-out co"><span class="r-pr">#&gt;</span>    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>  <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>      <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>             <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>          </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 1</span> chr2  <span style="text-decoration: underline;">41</span>612 C     T     hg38   Q1W6H9     ENST00000327669.5 R321Q          </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 2</span> chr2  <span style="text-decoration: underline;">41</span>612 C     A     hg38   Q1W6H9     ENST00000327669.5 R321L          </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 3</span> chr2  <span style="text-decoration: underline;">41</span>612 C     G     hg38   Q1W6H9     ENST00000327669.5 R321P          </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 4</span> chr2  <span style="text-decoration: underline;">41</span>613 G     C     hg38   Q1W6H9     ENST00000327669.5 R321G          </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 5</span> chr2  <span style="text-decoration: underline;">41</span>615 G     C     hg38   Q1W6H9     ENST00000327669.5 S320C          </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 6</span> chr2  <span style="text-decoration: underline;">41</span>615 G     A     hg38   Q1W6H9     ENST00000327669.5 S320F          </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 7</span> chr2  <span style="text-decoration: underline;">41</span>615 G     T     hg38   Q1W6H9     ENST00000327669.5 S320Y          </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 8</span> chr2  <span style="text-decoration: underline;">41</span>616 A     C     hg38   Q1W6H9     ENST00000327669.5 S320A          </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 9</span> chr2  <span style="text-decoration: underline;">41</span>616 A     G     hg38   Q1W6H9     ENST00000327669.5 S320P          </span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;">10</span> chr2  <span style="text-decoration: underline;">41</span>616 A     T     hg38   Q1W6H9     ENST00000327669.5 S320T          </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>    CHROM    POS REF   ALT   genome uniprot_id transcript_id     protein_variant</span>
+<span class="r-out co"><span class="r-pr">#&gt;</span>    <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>  <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>  <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>      <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>             <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span>          </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 1</span> chr4  <span style="text-decoration: underline;">161</span>194 C     G     hg38   Q3SXZ3     ENST00000510175.6 T170S          </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 2</span> chr4  <span style="text-decoration: underline;">161</span>196 T     A     hg38   Q3SXZ3     ENST00000510175.6 F171I          </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 3</span> chr4  <span style="text-decoration: underline;">161</span>196 T     C     hg38   Q3SXZ3     ENST00000510175.6 F171L          </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 4</span> chr4  <span style="text-decoration: underline;">161</span>196 T     G     hg38   Q3SXZ3     ENST00000510175.6 F171V          </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 5</span> chr4  <span style="text-decoration: underline;">161</span>197 T     G     hg38   Q3SXZ3     ENST00000510175.6 F171C          </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 6</span> chr4  <span style="text-decoration: underline;">161</span>197 T     C     hg38   Q3SXZ3     ENST00000510175.6 F171S          </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 7</span> chr4  <span style="text-decoration: underline;">161</span>197 T     A     hg38   Q3SXZ3     ENST00000510175.6 F171Y          </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 8</span> chr4  <span style="text-decoration: underline;">161</span>198 T     A     hg38   Q3SXZ3     ENST00000510175.6 F171L          </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;"> 9</span> chr4  <span style="text-decoration: underline;">161</span>198 T     G     hg38   Q3SXZ3     ENST00000510175.6 F171L          </span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #BCBCBC;">10</span> chr4  <span style="text-decoration: underline;">161</span>199 A     C     hg38   Q3SXZ3     ENST00000510175.6 K172Q          </span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># ℹ more rows</span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># ℹ 4 more variables: am_pathogenicity &lt;dbl&gt;, am_class &lt;chr&gt;, start &lt;dbl&gt;,</span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;">#   end &lt;dbl&gt;</span></span>
 <span class="r-in"><span><span class="va">rng</span> <span class="op">|&gt;</span></span></span>
-<span class="r-in"><span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/count.html" class="external-link">count</a></span><span class="op">(</span><span class="va">CHROM</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
-<span class="r-in"><span>    <span class="fu"><a href="https://dplyr.tidyverse.org/reference/arrange.html" class="external-link">arrange</a></span><span class="op">(</span><span class="va">CHROM</span><span class="op">)</span></span></span>
+<span class="r-in"><span>    <span class="fu">count</span><span class="op">(</span><span class="va">CHROM</span><span class="op">)</span> <span class="op">|&gt;</span></span></span>
+<span class="r-in"><span>    <span class="fu">arrange</span><span class="op">(</span><span class="va">CHROM</span><span class="op">)</span></span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Source:     SQL [3 x 2]</span></span>
-<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Database:   DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e]</span></span>
+<span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Database:   DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc]</span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span> <span style="color: #949494;"># Ordered by: CHROM</span></span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>   CHROM     n</span>
 <span class="r-out co"><span class="r-pr">#&gt;</span>   <span style="color: #949494; font-style: italic;">&lt;chr&gt;</span> <span style="color: #949494; font-style: italic;">&lt;dbl&gt;</span></span>
@@ -311,7 +287,7 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 <span class="r-in"><span></span></span>
 </code></pre></div>
     </div>
-  </main><aside class="col-md-3"><nav id="toc"><h2>On this page</h2>
+  </main><aside class="col-md-3"><nav id="toc" aria-label="Table of contents"><h2>On this page</h2>
     </nav></aside></div>
 
 
@@ -320,14 +296,14 @@ <h2 id="ref-examples">Examples<a class="anchor" aria-label="anchor" href="#ref-e
 </div>
 
 <div class="pkgdown-footer-right">
-  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.9.</p>
+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
 </div>
 
     </footer></div>
 
-  
 
-  
+
+
 
   </body></html>
 
diff --git a/reference/db_disconnect.html b/reference/db_disconnect.html
new file mode 100644
index 0000000..7560b68
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diff --git a/reference/db_disconnect_all.html b/reference/db_disconnect_all.html
new file mode 100644
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+++ b/reference/db_disconnect_all.html
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diff --git a/reference/db_range_join.html b/reference/db_range_join.html
new file mode 100644
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+++ b/reference/db_range_join.html
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diff --git a/reference/db_tables.html b/reference/db_tables.html
new file mode 100644
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+++ b/reference/db_tables.html
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diff --git a/reference/db_temporary_table.html b/reference/db_temporary_table.html
new file mode 100644
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diff --git a/reference/index.html b/reference/index.html
index 1a852a1..af680fe 100644
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-      <img src="" class="logo" alt=""><h1>Function reference</h1>
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+      <h1>Package index</h1>
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       <h2 id="all-functions">All functions<a class="anchor" aria-label="anchor" href="#all-functions"></a></h2>
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-      
-      
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+
+
+
+    </div><div class="section level2">
+
+
+
 
       <dl><dt>
-          
-          <code><a href="AlphaFold.html">af_predictions()</a></code> <code><a href="AlphaFold.html">af_prediction_view()</a></code> <code><a href="AlphaFold.html">af_colorfunc_by_position()</a></code> 
+
+          <code><a href="AlphaFold.html">af_predictions()</a></code> <code><a href="AlphaFold.html">af_prediction_view()</a></code> <code><a href="AlphaFold.html">af_colorfunc_by_position()</a></code>
+
         </dt>
         <dd>AlphaFold Protein Structure Retrieval and Display</dd>
       </dl><dl><dt>
-          
-          <code><a href="AlphaMissense.html">ALPHAMISSENSE_RECORD</a></code> <code><a href="AlphaMissense.html">am_browse()</a></code> <code><a href="AlphaMissense.html">am_available()</a></code> <code><a href="AlphaMissense.html">am_data()</a></code> 
+
+          <code><a href="AlphaMissense.html">ALPHAMISSENSE_RECORD</a></code> <code><a href="AlphaMissense.html">am_browse()</a></code> <code><a href="AlphaMissense.html">am_available()</a></code> <code><a href="AlphaMissense.html">am_data()</a></code>
+
         </dt>
         <dd>Retrieve AlphaMissense Resources as DuckDB Databases</dd>
       </dl><dl><dt>
-          
-          <code><a href="ClinVar.html">clinvar_data()</a></code> <code><a href="ClinVar.html">clinvar_plot()</a></code> 
+
+          <code><a href="ClinVar.html">clinvar_data()</a></code> <code><a href="ClinVar.html">clinvar_plot()</a></code>
+
         </dt>
         <dd>Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores</dd>
       </dl><dl><dt>
-          
-          <code><a href="GenomicRanges.html">to_GPos()</a></code> 
+
+          <code><a href="GenomicRanges.html">to_GPos()</a></code>
+
         </dt>
         <dd>Create GenomicRanges Objects from AlphaMissense Annotations</dd>
       </dl><dl><dt>
-          
-          <code><a href="am_aa.html">am_aa_pos()</a></code> <code><a href="am_aa.html">am_aa_pathogenicity()</a></code> 
+
+          <code><a href="Gosling.html">gosling_plot()</a></code>
+
+        </dt>
+        <dd>Plot a GPos or GRanges Object Using Shiny and Gosling</dd>
+      </dl><dl><dt>
+
+          <code><a href="am_aa.html">am_aa_pos()</a></code> <code><a href="am_aa.html">am_aa_pathogenicity()</a></code>
+
         </dt>
         <dd>Common Amino Acid-level Transformations</dd>
       </dl><dl><dt>
-          
-          <code><a href="db.html">db_connect()</a></code> <code><a href="db.html">db_tables()</a></code> <code><a href="db.html">db_temporary_table()</a></code> <code><a href="db.html">db_range_join()</a></code> <code><a href="db.html">db_disconnect()</a></code> <code><a href="db.html">db_disconnect_all()</a></code> 
+
+          <code><a href="db.html">db_connect()</a></code> <code><a href="db.html">db_tables()</a></code> <code><a href="db.html">db_temporary_table()</a></code> <code><a href="db.html">db_range_join()</a></code> <code><a href="db.html">db_disconnect()</a></code> <code><a href="db.html">db_disconnect_all()</a></code>
+
         </dt>
         <dd>Manipulate the Database of Missense Mutations</dd>
       </dl></div>
@@ -102,14 +100,14 @@ <h2 id="all-functions">All functions<a class="anchor" aria-label="anchor" href="
 </div>
 
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+  <p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.1.0.</p>
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diff --git a/search.json b/search.json
index 6cefa61..21a478a 100644
--- a/search.json
+++ b/search.json
@@ -1 +1 @@
-[{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"B. AlphaFold Integration","text":"vignette illustrates display AlphaMissense predictions AlphaFold predicted protein structure. Visualization makes use CRAN packages bio3d r3dmol. Install (necessary) Start loading AlphaMissenseR library. Visit summary available AlphaMissense datasets vignette uses aa_substitutions hg38 data resources; make sure cached locally.","code":"pkgs <- c(\"bio3d\", \"r3dmol\") pkgs_to_install <- pkgs[!pkgs %in% rownames(installed.packages())] if (length(pkgs_to_install))     BiocManager::install(pkgs_to_install) library(AlphaMissenseR) am_available() #> # A tibble: 7 × 6 #>   record   key                             size cached filename            link  #>   <chr>    <chr>                          <dbl> <lgl>  <chr>               <chr> #> 1 10813168 gene_hg38                     253636 TRUE   AlphaMissense_gene… http… #> 2 10813168 isoforms_hg38             1177361934 FALSE  AlphaMissense_isof… http… #> 3 10813168 isoforms_aa_substitutions 2461351945 FALSE  AlphaMissense_isof… http… #> 4 10813168 hg38                       642961469 TRUE   AlphaMissense_hg38… http… #> 5 10813168 hg19                       622293310 FALSE  AlphaMissense_hg19… http… #> 6 10813168 gene_hg19                     243943 FALSE  AlphaMissense_gene… http… #> 7 10813168 aa_substitutions          1207278510 TRUE   AlphaMissense_aa_s… http… am_data(\"aa_substitutions\") #> # Source:   table<aa_substitutions> [?? x 4] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>    uniprot_id protein_variant am_pathogenicity am_class   #>    <chr>      <chr>                      <dbl> <chr>      #>  1 A0A024R1R8 M1A                        0.467 ambiguous  #>  2 A0A024R1R8 M1C                        0.383 ambiguous  #>  3 A0A024R1R8 M1D                        0.827 pathogenic #>  4 A0A024R1R8 M1E                        0.524 ambiguous  #>  5 A0A024R1R8 M1F                        0.275 benign     #>  6 A0A024R1R8 M1G                        0.548 ambiguous  #>  7 A0A024R1R8 M1H                        0.552 ambiguous  #>  8 A0A024R1R8 M1I                        0.321 benign     #>  9 A0A024R1R8 M1K                        0.288 benign     #> 10 A0A024R1R8 M1L                        0.175 benign     #> # ℹ more rows am_data(\"hg38\") #> # Source:   table<hg38> [?? x 10] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr> <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr1  69094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L             #>  2 chr1  69094 G     C     hg38   Q8NH21     ENST00000335137.4 V2L             #>  3 chr1  69094 G     A     hg38   Q8NH21     ENST00000335137.4 V2M             #>  4 chr1  69095 T     C     hg38   Q8NH21     ENST00000335137.4 V2A             #>  5 chr1  69095 T     A     hg38   Q8NH21     ENST00000335137.4 V2E             #>  6 chr1  69095 T     G     hg38   Q8NH21     ENST00000335137.4 V2G             #>  7 chr1  69097 A     G     hg38   Q8NH21     ENST00000335137.4 T3A             #>  8 chr1  69097 A     C     hg38   Q8NH21     ENST00000335137.4 T3P             #>  9 chr1  69097 A     T     hg38   Q8NH21     ENST00000335137.4 T3S             #> 10 chr1  69098 C     A     hg38   Q8NH21     ENST00000335137.4 T3N             #> # ℹ more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr>"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"alphafold-protein-structure","dir":"Articles","previous_headings":"","what":"AlphaFold protein structure","title":"B. AlphaFold Integration","text":"AlphaMissense predictions pathogenicity amino acid changes can combined AlphaFold () predictions protein structure.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"fast-path","dir":"Articles","previous_headings":"AlphaFold protein structure","what":"Fast path","title":"B. AlphaFold Integration","text":"Figure 3F AlphaMissense publication visualizes mean pathogenicity UniProt id P35557. Filter amino acid data identifier visualization median pathogenicity image interactive, including rotation zoom. following sections explore visualization detail.","code":"P35557_aa <-     am_data(\"aa_substitutions\") |>     dplyr::filter(uniprot_id == \"P35557\") af_prediction_view(P35557_aa)"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"uniprot-identifiers","dir":"Articles","previous_headings":"AlphaFold protein structure","what":"UniProt identifiers","title":"B. AlphaFold Integration","text":"AlphaMissense AlphaFold use UniProt identifiers. Find AlphaMissense amino acid substitutions UniProt identifiers starting P3555; choice identifier results can compared Figure 3F AlphaMissense publication. AlphaMissenseR package includes several functions facilitate interaction AlphaFold; functions start af_*(). Use af_predictions() discover AlphaFold predictions (via AlphaFold API) associated UniProt identifiers. Note message indicating UniProt identifiers (accessions) found AlphaFold database. query returns tibble containing columns information organism UniProt characteristics (including protein sequence) , well URLs files representing three-dimensional protein structure. use pdbUrl.","code":"uniprot_ids <-     am_data(\"aa_substitutions\") |>     dplyr::filter(uniprot_id %like% \"P3555%\") |>     dplyr::distinct(uniprot_id) |>     pull(uniprot_id) uniprot_ids #> [1] \"P35558\" \"P35557\" \"P35556\" \"P35555\" prediction <- af_predictions(uniprot_ids) #> * [14:05:13][info] 2 of 4 uniprot accessions not found #>   'P35556', 'P35555' glimpse(prediction) #> Rows: 2 #> Columns: 23 #> $ entryId                <chr> \"AF-P35558-F1\", \"AF-P35557-F1\" #> $ gene                   <chr> \"PCK1\", \"GCK\" #> $ uniprotAccession       <chr> \"P35558\", \"P35557\" #> $ uniprotId              <chr> \"PCKGC_HUMAN\", \"HXK4_HUMAN\" #> $ uniprotDescription     <chr> \"Phosphoenolpyruvate carboxykinase, cytosolic [… #> $ taxId                  <int> 9606, 9606 #> $ organismScientificName <chr> \"Homo sapiens\", \"Homo sapiens\" #> $ uniprotStart           <int> 1, 1 #> $ uniprotEnd             <int> 622, 465 #> $ uniprotSequence        <chr> \"MPPQLQNGLNLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHIC… #> $ modelCreatedDate       <chr> \"2022-06-01\", \"2022-06-01\" #> $ latestVersion          <int> 4, 4 #> $ allVersions            <list> [1, 2, 3, 4], [1, 2, 3, 4] #> $ isReviewed             <lgl> TRUE, TRUE #> $ isReferenceProteome    <lgl> TRUE, TRUE #> $ cifUrl                 <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ bcifUrl                <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ pdbUrl                 <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ paeImageUrl            <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ paeDocUrl              <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ amAnnotationsUrl       <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ amAnnotationsHg19Url   <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ amAnnotationsHg38Url   <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1…"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"protein-structure","dir":"Articles","previous_headings":"AlphaFold protein structure","what":"Protein structure","title":"B. AlphaFold Integration","text":"Focus particular UniProt identifier PDB url. Cache PDB file using BiocFileCache, read PDB file using bio3d. Visualize protein using r3dmol, using ‘cartoon’ style.","code":"pdb_url <-     prediction |>     dplyr::filter(uniprotAccession == \"P35557\") |>     dplyr::pull(pdbUrl) pdb_file <- BiocFileCache::bfcrpath(rnames = basename(pdb_url), fpath = pdb_url) pdb <- bio3d::read.pdb(pdb_file) pdb #>  #>  Call:  bio3d::read.pdb(file = pdb_file) #>  #>    Total Models#: 1 #>      Total Atoms#: 3642,  XYZs#: 10926  Chains#: 1  (values: A) #>  #>      Protein Atoms#: 3642  (residues/Calpha atoms#: 465) #>      Nucleic acid Atoms#: 0  (residues/phosphate atoms#: 0) #>  #>      Non-protein/nucleic Atoms#: 0  (residues: 0) #>      Non-protein/nucleic resid values: [ none ] #>  #>    Protein sequence: #>       MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT #>       YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE #>       MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN #>       VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMI...<cut>...MLGQ #>  #> + attr: atom, xyz, seqres, calpha, call r3dmol::r3dmol() |>     ## use the PDB representation     r3dmol::m_add_model(r3dmol::m_bio3d(pdb)) |>     ## visualize as a 'cartoon' with alpha helices and beta sheets     r3dmol::m_set_style(style = r3dmol::m_style_cartoon(arrow = TRUE)) |>     ## fit molecule into display area     r3dmol::m_zoom_to()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"average-pathogenicity","dir":"Articles","previous_headings":"AlphaFold protein structure","what":"Average pathogenicity","title":"B. AlphaFold Integration","text":"goal visualize measure ‘average’ pathogenicity three-dimensional protein structure provided AlphaFold. Start specific genome sequence (e.g., hg38). Filter amino acids UniProt region interest. chromosome position, AlphaMissense predictions contain several alternative alleles hence protein variants. (arithmetic) average pathogenicity (extremely naive computation) amino acid position ","code":"P35557 <-     am_data(\"hg38\") |>     dplyr::filter(uniprot_id == \"P35557\") pathogenicity <- am_aa_pathogenicity(P35557) pathogenicity #> # A tibble: 464 × 9 #>    uniprot_id aa_pos aa_ref aa_pathogenicity_n aa_pathogenicity_mean #>    <chr>       <int> <chr>               <int>                 <dbl> #>  1 P35557          2 L                       5                0.0818 #>  2 P35557          3 D                       8                0.184  #>  3 P35557          4 D                       8                0.147  #>  4 P35557          5 R                       6                0.250  #>  5 P35557          6 A                       6                0.138  #>  6 P35557          7 R                       7                0.257  #>  7 P35557          8 M                       9                0.142  #>  8 P35557          9 E                       7                0.212  #>  9 P35557         10 A                       6                0.142  #> 10 P35557         11 A                       6                0.142  #> # ℹ 454 more rows #> # ℹ 4 more variables: aa_pathogenicity_median <dbl>, #> #   aa_pathogenicity_min <dbl>, aa_pathogenicity_max <dbl>, #> #   aa_pathogenicity_mode <fct>"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"coloring-amino-acids-by-position","dir":"Articles","previous_headings":"AlphaFold protein structure","what":"Coloring amino acids by position","title":"B. AlphaFold Integration","text":"Individual amino acids can colored using colorfunc= argument r3dmol::m_style_cartoon(). Javascript function takes atom position returns corresponding color. approach taken AlphaMissenseR use template, ultimately replacing ... vector residue colors. function af_colorfunc_by_position() provides mechanism translating vector scores zero one vector colors. illustrated 12-amino acid sequence first last residues uncolored. following color function similar used af_prediction_view(), uses mean rather median pathogenicity scales palette minimum maximum values mean pathogenicity vector, rather 0 1. Add colorfunc= argument m_style_cartoon() visualization.","code":"cat(     AlphaMissenseR:::js_template(\"colorfunc\", colors = \"...\"),     \"\\n\" ) #> function(atom) { #>     const residue_colors = [ ... ]; #>     return residue_colors[atom.resi]; #> } df <- tibble(     pos = 1 + 1:10, # no color information for position 1     value = 10:1 / 10 ) colorfunc <- af_colorfunc_by_position(     df,     \"pos\", \"value\",     pos_max = 12    # no color information for position 12 ) cat(colorfunc, \"\\n\") #> function(atom) { #>     const residue_colors = [ 'gray', '#8E063B', '#AB5468', '#C18692', '#D2B0B6', '#DDD0D2', '#D2D3DC', '#B3B7CF', '#8C94BF', '#5D6CAE', '#023FA5', 'gray' ]; #>     return residue_colors[atom.resi]; #> } colorfunc <-     pathogenicity |>     af_colorfunc_by_position(         \"aa_pos\", \"aa_pathogenicity_mean\",         length(pdb$seqres)     ) r3dmol::r3dmol() |>     ## use the PDB representation     r3dmol::m_add_model(r3dmol::m_bio3d(pdb)) |>     ## visualize as a 'cartoon' with alpha helices and beta sheets     r3dmol::m_set_style(         style = r3dmol::m_style_cartoon(             arrow = TRUE,             ## color residue according to colorfunc             colorfunc = colorfunc         )     ) |>     ## fit molecule into display area     r3dmol::m_zoom_to()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"finally","dir":"Articles","previous_headings":"","what":"Finally","title":"B. AlphaFold Integration","text":"Remember disconnect shutdown managed DuckDB connections. Database connections closed correctly trigger warning messages.","code":"db_disconnect_all()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"session-information","dir":"Articles","previous_headings":"","what":"Session information","title":"B. AlphaFold Integration","text":"","code":"sessionInfo() #> R version 4.4.1 Patched (2024-06-20 r86819) #> Platform: aarch64-apple-darwin23.5.0 #> Running under: macOS Sonoma 14.5 #>  #> Matrix products: default #> BLAS:   /Users/ma38727/bin/R-4-4-branch/lib/libRblas.dylib  #> LAPACK: /Users/ma38727/bin/R-4-4-branch/lib/libRlapack.dylib;  LAPACK version 3.12.0 #>  #> locale: #> [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 #>  #> time zone: America/New_York #> tzcode source: internal #>  #> attached base packages: #> [1] stats     graphics  grDevices utils     datasets  methods   base      #>  #> other attached packages: #> [1] AlphaMissenseR_1.1.5 dplyr_1.1.4          #>  #> loaded via a namespace (and not attached): #>  [1] gtable_0.3.5         xfun_0.45            bslib_0.7.0          #>  [4] ggplot2_3.5.1        htmlwidgets_1.6.4    vctrs_0.6.5          #>  [7] rjsoncons_1.3.0      tools_4.4.1          generics_0.1.3       #> [10] curl_5.2.1           parallel_4.4.1       tibble_3.2.1         #> [13] fansi_1.0.6          RSQLite_2.3.7        blob_1.2.4           #> [16] pkgconfig_2.0.3      BiocBaseUtils_1.7.0  dbplyr_2.5.0         #> [19] desc_1.4.3           RcppSpdlog_0.0.17    lifecycle_1.0.4      #> [22] compiler_4.4.1       textshaping_0.4.0    munsell_0.5.1        #> [25] httpuv_1.6.15        htmltools_0.5.8.1    sass_0.4.9           #> [28] yaml_2.3.8           pillar_1.9.0         pkgdown_2.0.9        #> [31] later_1.3.2          jquerylib_0.1.4      whisker_0.4.1        #> [34] tidyr_1.3.1          cachem_1.1.0         mime_0.12            #> [37] tidyselect_1.2.1     r3dmol_0.1.2         digest_0.6.36        #> [40] duckdb_1.0.0         purrr_1.0.2          fastmap_1.2.0        #> [43] grid_4.4.1           colorspace_2.1-0     cli_3.6.3            #> [46] magrittr_2.0.3       spdl_0.0.5           utf8_1.2.4           #> [49] withr_3.0.0          promises_1.3.0       filelock_1.0.3       #> [52] scales_1.3.0         bit64_4.0.5          rmarkdown_2.27       #> [55] httr_1.4.7           bit_4.0.5            ragg_1.3.2           #> [58] memoise_2.0.1        shiny_1.8.1.1        evaluate_0.24.0      #> [61] knitr_1.47           bio3d_2.4-4          BiocFileCache_2.13.0 #> [64] rlang_1.1.4          Rcpp_1.0.12          xtable_1.8-4         #> [67] glue_1.7.0           DBI_1.2.3            jsonlite_1.8.8       #> [70] R6_2.5.1             systemfonts_1.1.0    fs_1.6.4"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/clinvar.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"C. ClinVar Integration","text":"ClinVar freely available, public archive human genetic variants provides clinical classifications whether variant likely benign pathogenic. AlphaMissense publication uses ClinVar data evaluate calibrate predictions generated model. table containing ClinVar information 82872 variants across 7951 proteins derived supplemental data AlphaMissense paper, made available package benchmarking visualization purposes.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/clinvar.html","id":"access-clinvar-classifications-with-alphamissense-predictions","dir":"Articles","previous_headings":"","what":"Access ClinVar classifications with AlphaMissense predictions","title":"C. ClinVar Integration","text":"ClinVar table can accessed using clinvar_data() database. ClinVar table now available exploration parsing.","code":"clinvar_data() #> # Source:   table<clinvar> [?? x 5] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>    variant_id           transcript_id     protein_variant AlphaMissense label  #>    <chr>                <chr>             <chr>                   <dbl> <fct>  #>  1 chr1_925969_C_T_hg38 ENST00000342066.8 Q96NU1:P10S            0.967  benign #>  2 chr1_930165_G_A_hg38 ENST00000342066.8 Q96NU1:R28Q            0.663  benign #>  3 chr1_930204_G_A_hg38 ENST00000342066.8 Q96NU1:R41Q            0.0866 benign #>  4 chr1_930245_G_A_hg38 ENST00000342066.8 Q96NU1:D55N            0.134  benign #>  5 chr1_930248_G_A_hg38 ENST00000342066.8 Q96NU1:G56S            0.100  benign #>  6 chr1_930282_G_A_hg38 ENST00000342066.8 Q96NU1:R67Q            0.0635 benign #>  7 chr1_930285_G_A_hg38 ENST00000342066.8 Q96NU1:R68Q            0.0629 benign #>  8 chr1_930314_C_T_hg38 ENST00000342066.8 Q96NU1:H78Y            0.110  benign #>  9 chr1_930320_C_T_hg38 ENST00000342066.8 Q96NU1:R80C            0.0918 benign #> 10 chr1_931058_G_A_hg38 ENST00000342066.8 Q96NU1:V92M            0.196  benign #> # ℹ more rows"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/clinvar.html","id":"compare-clinvar-and-alphamissense","dir":"Articles","previous_headings":"","what":"Compare ClinVar and AlphaMissense","title":"C. ClinVar Integration","text":"section uses clinvar_plot() function generate scatterplot benchmarking comparing ClinVar classification AlphaMissense predictions. default, function takes one UniProt accession identifier, derives AlphaMissense scores am_data(\"aa_substitution\"), pulls ClinVar classifications data.frame previously obtained. Alternatively, possible pass custom AlphaMissense ClinVar table function. See function details information.  returned ggplot object overlays ClinVar classifications onto AlphaMissense predicted scores. Blue, gray, red colors represent pathogenicity classifications “likely benign”, “ambiguous”, “likely pathogenic”, respectively. Large, bolded points ClinVar variants colored according clinical classification, smaller points background AlphaMissense predictions. can note discrepancy clinically-validated annotations AlphaMissense predictions around position 50. AlphaMissense seems predict several variants region likely benign, ClinVar identifies pathogenic. ClinVar dataset exhaustive (proteins clinically-assessed), may proteins information available. case, function provide error. Remember disconnect database.","code":"clinvar_plot(uniprotId = \"P37023\") #> * [14:05:22][info] 'alphamissense_table' not provided, using default 'am_data(\"aa_substitution\")' table accessed through the AlphaMissenseR package #> * [14:05:24][info] 'clinvar_table' not provided, using default ClinVar dataset in AlphaMissenseR package db_disconnect_all()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/clinvar.html","id":"session-information","dir":"Articles","previous_headings":"","what":"Session information","title":"C. ClinVar Integration","text":"","code":"sessionInfo() #> R version 4.4.1 Patched (2024-06-20 r86819) #> Platform: aarch64-apple-darwin23.5.0 #> Running under: macOS Sonoma 14.5 #>  #> Matrix products: default #> BLAS:   /Users/ma38727/bin/R-4-4-branch/lib/libRblas.dylib  #> LAPACK: /Users/ma38727/bin/R-4-4-branch/lib/libRlapack.dylib;  LAPACK version 3.12.0 #>  #> locale: #> [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 #>  #> time zone: America/New_York #> tzcode source: internal #>  #> attached base packages: #> [1] stats     graphics  grDevices utils     datasets  methods   base      #>  #> other attached packages: #> [1] AlphaMissenseR_1.1.5 dplyr_1.1.4          #>  #> loaded via a namespace (and not attached): #>  [1] tidyr_1.3.1          sass_0.4.9           utf8_1.2.4           #>  [4] generics_0.1.3       spdl_0.0.5           RSQLite_2.3.7        #>  [7] digest_0.6.36        magrittr_2.0.3       evaluate_0.24.0      #> [10] grid_4.4.1           fastmap_1.2.0        blob_1.2.4           #> [13] jsonlite_1.8.8       whisker_0.4.1        DBI_1.2.3            #> [16] httr_1.4.7           purrr_1.0.2          fansi_1.0.6          #> [19] scales_1.3.0         textshaping_0.4.0    jquerylib_0.1.4      #> [22] duckdb_1.0.0         cli_3.6.3            rlang_1.1.4          #> [25] dbplyr_2.5.0         bit64_4.0.5          munsell_0.5.1        #> [28] withr_3.0.0          cachem_1.1.0         yaml_2.3.8           #> [31] BiocBaseUtils_1.7.0  tools_4.4.1          memoise_2.0.1        #> [34] colorspace_2.1-0     ggplot2_3.5.1        filelock_1.0.3       #> [37] curl_5.2.1           rjsoncons_1.3.0      vctrs_0.6.5          #> [40] R6_2.5.1             BiocFileCache_2.13.0 lifecycle_1.0.4      #> [43] RcppSpdlog_0.0.17    fs_1.6.4             htmlwidgets_1.6.4    #> [46] bit_4.0.5            ragg_1.3.2           pkgconfig_2.0.3      #> [49] desc_1.4.3           pkgdown_2.0.9        pillar_1.9.0         #> [52] bslib_0.7.0          gtable_0.3.5         Rcpp_1.0.12          #> [55] glue_1.7.0           systemfonts_1.1.0    highr_0.11           #> [58] xfun_0.45            tibble_3.2.1         tidyselect_1.2.1     #> [61] knitr_1.47           farver_2.1.2         htmltools_0.5.8.1    #> [64] labeling_0.4.3       rmarkdown_2.27       compiler_4.4.1"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"A. Introduction","text":"AlphaMissense publication outlines variant AlphaFold / DeepMind used predict missense variant pathogenicity. Supporting data Zenodo include, instance 70+M variants across hg19 hg38 genome builds. AlphaMissense package allows ready access data, downloading individual files DuckDB databases ready exploration integration R Bioconductor workflows. Install package Bioconductor GitHub, ensuring correct Bioconductor dependencies. package available Bioconductor, use Use pre-release devel version Load library. Learn available data visiting Zenodo record data retrieved .","code":"if (!\"BiocManager\" %in% rownames(installed.packages()))     install.packages(\"BiocManager\", repos = \"https://cran.r-project.org\") if (BiocManager::version() >= \"3.19\") {     BiocManager::install(\"AlphaMissenseR\") } else {     stop(         \"'AlphaMissenseR' requires Bioconductor version 3.19 or later, \",         \"install from GitHub?\"     ) } remotes::install_github(     \"mtmorgan/AlphaMissenseR\",     repos = BiocManager::repositories() ) library(AlphaMissenseR) am_browse()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"discovery-retrieval-and-use","dir":"Articles","previous_headings":"","what":"Discovery, retrieval and use","title":"A. Introduction","text":"Use am_available() discover data resources available representation DuckDB databases. cached column initially FALSE data sets; TRUE indicates data set downloaded am_data(), described . available data sets use recent record 25 September, 2023; can changed specifying alternative record= argument changed globally setting environment variable ALPHAMISSENSE_RECORD loading package. Use am_data() download data resource store DuckDB database. key= argument column returned am_available(). Files cached locally (using BiocFileCache) operation expensive first time. record= stored different database. return value tbl table DuckDB database. (read-) connection database available connection remains open throughout session; call db_disconnect(db) db_disconnect_all() close end session. database contains tables key downloaded. alternative am_available() / am_data(), view available tables create dplyr / dbplyr tibble table interest. fast straight-forward summarize data, e.g., number variants assigned pathogenicity class. average pathogenicity score class… number transitions REF ALT nucleotides across variants. straight-forward select variants individual regions interest, e.g., first 200000 nucleoties chromosome 4.","code":"am_available() #> # A tibble: 7 × 6 #>   record   key                             size cached filename            link  #>   <chr>    <chr>                          <dbl> <lgl>  <chr>               <chr> #> 1 10813168 gene_hg38                     253636 TRUE   AlphaMissense_gene… http… #> 2 10813168 isoforms_hg38             1177361934 FALSE  AlphaMissense_isof… http… #> 3 10813168 isoforms_aa_substitutions 2461351945 FALSE  AlphaMissense_isof… http… #> 4 10813168 hg38                       642961469 TRUE   AlphaMissense_hg38… http… #> 5 10813168 hg19                       622293310 FALSE  AlphaMissense_hg19… http… #> 6 10813168 gene_hg19                     243943 FALSE  AlphaMissense_gene… http… #> 7 10813168 aa_substitutions          1207278510 TRUE   AlphaMissense_aa_s… http… tbl <- am_data(\"hg38\") tbl #> # Source:   table<hg38> [?? x 10] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr> <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr1  69094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L             #>  2 chr1  69094 G     C     hg38   Q8NH21     ENST00000335137.4 V2L             #>  3 chr1  69094 G     A     hg38   Q8NH21     ENST00000335137.4 V2M             #>  4 chr1  69095 T     C     hg38   Q8NH21     ENST00000335137.4 V2A             #>  5 chr1  69095 T     A     hg38   Q8NH21     ENST00000335137.4 V2E             #>  6 chr1  69095 T     G     hg38   Q8NH21     ENST00000335137.4 V2G             #>  7 chr1  69097 A     G     hg38   Q8NH21     ENST00000335137.4 T3A             #>  8 chr1  69097 A     C     hg38   Q8NH21     ENST00000335137.4 T3P             #>  9 chr1  69097 A     T     hg38   Q8NH21     ENST00000335137.4 T3S             #> 10 chr1  69098 C     A     hg38   Q8NH21     ENST00000335137.4 T3N             #> # ℹ more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr> db <- db_connect() db_tables(db) #> [1] \"aa_substitutions\" \"clinvar\"          \"gene_hg38\"        \"hg38\" tbl <- tbl(db, \"hg38\") tbl #> # Source:   table<hg38> [?? x 10] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr> <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr1  69094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L             #>  2 chr1  69094 G     C     hg38   Q8NH21     ENST00000335137.4 V2L             #>  3 chr1  69094 G     A     hg38   Q8NH21     ENST00000335137.4 V2M             #>  4 chr1  69095 T     C     hg38   Q8NH21     ENST00000335137.4 V2A             #>  5 chr1  69095 T     A     hg38   Q8NH21     ENST00000335137.4 V2E             #>  6 chr1  69095 T     G     hg38   Q8NH21     ENST00000335137.4 V2G             #>  7 chr1  69097 A     G     hg38   Q8NH21     ENST00000335137.4 T3A             #>  8 chr1  69097 A     C     hg38   Q8NH21     ENST00000335137.4 T3P             #>  9 chr1  69097 A     T     hg38   Q8NH21     ENST00000335137.4 T3S             #> 10 chr1  69098 C     A     hg38   Q8NH21     ENST00000335137.4 T3N             #> # ℹ more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr> tbl |>     count(am_class) #> # Source:   SQL [3 x 2] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>   am_class                 n #>   <chr>                <dbl> #> 1 likely_pathogenic 22770557 #> 2 ambiguous          8009648 #> 3 likely_benign     40917351 tbl |>     group_by(am_class) |>     summarize(n = n(), pathogenecity = mean(am_pathogenicity, na.rm = TRUE)) #> # Source:   SQL [3 x 3] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>   am_class                 n pathogenecity #>   <chr>                <dbl>         <dbl> #> 1 likely_benign     40917351         0.147 #> 2 likely_pathogenic 22770557         0.863 #> 3 ambiguous          8009648         0.444 tbl |>     count(REF, ALT) |>     tidyr::pivot_wider(names_from = \"ALT\", values_from = \"n\") |>     select(\"REF\", \"A\", \"C\", \"G\", \"T\") |>     arrange(REF) #> # Source:     SQL [4 x 5] #> # Database:   DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #> # Ordered by: REF #>   REF         A       C       G       T #>   <chr>   <dbl>   <dbl>   <dbl>   <dbl> #> 1 A          NA 6420083 5449617 5953590 #> 2 C     6183248      NA 6963298 4909869 #> 3 G     4894493 6937258      NA 6161594 #> 4 T     5955039 5445540 6423927      NA tbl |>     filter(CHROM == \"chr4\", POS > 0, POS <= 200000) #> # Source:   SQL [?? x 10] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr> <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr4  59430 G     C     hg38   Q8IYB9     ENST00000610261.6 E2Q             #>  2 chr4  59430 G     A     hg38   Q8IYB9     ENST00000610261.6 E2K             #>  3 chr4  59431 A     C     hg38   Q8IYB9     ENST00000610261.6 E2A             #>  4 chr4  59431 A     G     hg38   Q8IYB9     ENST00000610261.6 E2G             #>  5 chr4  59431 A     T     hg38   Q8IYB9     ENST00000610261.6 E2V             #>  6 chr4  59432 A     C     hg38   Q8IYB9     ENST00000610261.6 E2D             #>  7 chr4  59432 A     T     hg38   Q8IYB9     ENST00000610261.6 E2D             #>  8 chr4  59433 C     A     hg38   Q8IYB9     ENST00000610261.6 L3I             #>  9 chr4  59433 C     T     hg38   Q8IYB9     ENST00000610261.6 L3F             #> 10 chr4  59433 C     G     hg38   Q8IYB9     ENST00000610261.6 L3V             #> # ℹ more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr>"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"working-with-bioconductor","dir":"Articles","previous_headings":"","what":"Working with Bioconductor","title":"A. Introduction","text":"section illustrates AlphaMissense data can integrated Bioconductor workflows, including GenomicRanges infrastructure ensembldb package / AnnotationHub resources.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"genomic-ranges","dir":"Articles","previous_headings":"Working with Bioconductor","what":"Genomic ranges","title":"A. Introduction","text":"GenomicRanges infrastructure provides standard data structures allow range-based operations across Bioconductor packages. GPos data structure provides convenient memory-efficient representation single-nucleotide variants like hg19 hg38 AlphaMissense resources. Start installing (necessary) GenomicRanges package. Select hg38 data resource, filter subset variants; GPos -memory data structure can easily manage 10’s millions variants. Use to_GPos() coerce GPos object. Vignettes GenomicRanges package illustrate use objects.","code":"if (!requireNamespace(\"GenomicRanges\", quietly = TRUE))     BiocManager::install(\"GenomicRanges\") tbl <-     am_data(\"hg38\") |>     filter(CHROM == \"chr2\", POS < 10000000, REF == \"G\") gpos <-     tbl |>     to_GPos() gpos #> UnstitchedGPos object with 26751 positions and 7 metadata columns: #>           seqnames       pos strand |         REF         ALT  uniprot_id #>              <Rle> <integer>  <Rle> | <character> <character> <character> #>       [1]     chr2     41613      * |           G           C      Q1W6H9 #>       [2]     chr2     41615      * |           G           C      Q1W6H9 #>       [3]     chr2     41615      * |           G           A      Q1W6H9 #>       [4]     chr2     41615      * |           G           T      Q1W6H9 #>       [5]     chr2     41618      * |           G           C      Q1W6H9 #>       ...      ...       ...    ... .         ...         ...         ... #>   [26747]     chr2   9999028      * |           G           A      Q9NZI5 #>   [26748]     chr2   9999028      * |           G           T      Q9NZI5 #>   [26749]     chr2   9999029      * |           G           C      Q9NZI5 #>   [26750]     chr2   9999029      * |           G           A      Q9NZI5 #>   [26751]     chr2   9999029      * |           G           T      Q9NZI5 #>                transcript_id protein_variant am_pathogenicity          am_class #>                  <character>     <character>        <numeric>       <character> #>       [1]  ENST00000327669.5           R321G           0.0848     likely_benign #>       [2]  ENST00000327669.5           S320C           0.0946     likely_benign #>       [3]  ENST00000327669.5           S320F           0.1593     likely_benign #>       [4]  ENST00000327669.5           S320Y           0.1429     likely_benign #>       [5]  ENST00000327669.5           P319R           0.0765     likely_benign #>       ...                ...             ...              ...               ... #>   [26747] ENST00000324907.14           G581R           0.9997 likely_pathogenic #>   [26748] ENST00000324907.14           G581W           0.9996 likely_pathogenic #>   [26749] ENST00000324907.14           G581A           0.9970 likely_pathogenic #>   [26750] ENST00000324907.14           G581E           0.9995 likely_pathogenic #>   [26751] ENST00000324907.14           G581V           0.9994 likely_pathogenic #>   ------- #>   seqinfo: 25 sequences (1 circular) from hg38 genome utils::browseVignettes(\"GenomicRanges\")"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"grch38-annotation-resources","dir":"Articles","previous_headings":"Working with Bioconductor","what":"GRCh38 annotation resources","title":"A. Introduction","text":"Start identifying recent EnsDb resource Homo Sapiens. Load ensembldb library retrieve record. Unfortunately, many conflicts function names different packages, becomes necessary fully resolve functions package defined.","code":"hub <- AnnotationHub::AnnotationHub() AnnotationHub::query(hub, c(\"EnsDb\", \"Homo sapiens\")) #> AnnotationHub with 27 records #> # snapshotDate(): 2024-06-21 #> # $dataprovider: Ensembl #> # $species: Homo sapiens #> # $rdataclass: EnsDb #> # additional mcols(): taxonomyid, genome, description, #> #   coordinate_1_based, maintainer, rdatadateadded, preparerclass, tags, #> #   rdatapath, sourceurl, sourcetype  #> # retrieve records with, e.g., 'object[[\"AH53211\"]]'  #>  #>              title                              #>   AH53211  | Ensembl 87 EnsDb for Homo Sapiens  #>   AH53715  | Ensembl 88 EnsDb for Homo Sapiens  #>   AH56681  | Ensembl 89 EnsDb for Homo Sapiens  #>   AH57757  | Ensembl 90 EnsDb for Homo Sapiens  #>   AH60773  | Ensembl 91 EnsDb for Homo Sapiens  #>   ...        ...                                #>   AH109336 | Ensembl 108 EnsDb for Homo sapiens #>   AH109606 | Ensembl 109 EnsDb for Homo sapiens #>   AH113665 | Ensembl 110 EnsDb for Homo sapiens #>   AH116291 | Ensembl 111 EnsDb for Homo sapiens #>   AH116860 | Ensembl 112 EnsDb for Homo sapiens AnnotationHub::AnnotationHub()[\"AH113665\"] #> AnnotationHub with 1 record #> # snapshotDate(): 2024-06-21 #> # names(): AH113665 #> # $dataprovider: Ensembl #> # $species: Homo sapiens #> # $rdataclass: EnsDb #> # $rdatadateadded: 2023-04-25 #> # $title: Ensembl 110 EnsDb for Homo sapiens #> # $description: Gene and protein annotations for Homo sapiens based on Ensem... #> # $taxonomyid: 9606 #> # $genome: GRCh38 #> # $sourcetype: ensembl #> # $sourceurl: http://www.ensembl.org #> # $sourcesize: NA #> # $tags: c(\"110\", \"Annotation\", \"AnnotationHubSoftware\", \"Coverage\", #> #   \"DataImport\", \"EnsDb\", \"Ensembl\", \"Gene\", \"Protein\", \"Sequencing\", #> #   \"Transcript\")  #> # retrieve record with 'object[[\"AH113665\"]]' library(ensembldb) edb <- AnnotationHub::AnnotationHub()[[\"AH113665\"]] edb #> EnsDb for Ensembl: #> |Backend: SQLite #> |Db type: EnsDb #> |Type of Gene ID: Ensembl Gene ID #> |Supporting package: ensembldb #> |Db created by: ensembldb package from Bioconductor #> |script_version: 0.3.10 #> |Creation time: Mon Aug  7 09:02:07 2023 #> |ensembl_version: 110 #> |ensembl_host: 127.0.0.1 #> |Organism: Homo sapiens #> |taxonomy_id: 9606 #> |genome_build: GRCh38 #> |DBSCHEMAVERSION: 2.2 #> |common_name: human #> |species: homo_sapiens #> | No. of genes: 71440. #> | No. of transcripts: 278545. #> |Protein data available."},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"from-bioconductor-to-duckdb","dir":"Articles","previous_headings":"Working with Bioconductor","what":"From Bioconductor to DuckDB","title":"A. Introduction","text":"section work directly database, including writing temporary tables. illustration purposes, use connection can read write; practice, read-permissions sufficient creating temporary tables. illustration, use ensembldb identify exons canonical transcript particular gene. Munge data tibble, updating seqnames column CHROM identifiers \"chr1\" (AlphaMissense data). Write tibble temporary table (deleted db disconnected database) can used ‘lazy’ SQL queries AlphaMissense data. temporary table now available db_rw connection; tables removed disconnect, db_disconnect(db_rw). Use db_range_join() join AlphaMissense data ranges defining exons gene interest. arguments database connection, AlphaMissense table interest (table must columns CHROM POS), table containing ranges interest (columns CHROM, start, end), temporary table contain results. range join like standard database join, expect constraints can relations, case POS >= start POS <= end range interest; implementation details DuckDB blog. range join uses closed intervals (start end positions included query), following Bioconductor convention. Writing temporary table avoids bringing potentially large datasets R memory, makes table available subsequent manipulation current session. query takes place almost instantly. larger query 71M variants 1000 ranges took 20 seconds. usual database dplyr verbs can used summarize results, e.g., number variants pathogenecity class exon. perhaps instructive review range join source inspiration computations might interest. best practice, disconnect writable database connection work complete.","code":"db_rw <- db_connect(read_only = FALSE) bcl2l11 <-     edb |>     ensembldb::filter(         ~ symbol == \"BCL2L11\" &             tx_biotype == \"protein_coding\" &             tx_is_canonical == TRUE     ) |>     exonsBy(\"tx\") bcl2l11 #> GRangesList object of length 1: #> $ENST00000393256 #> GRanges object with 4 ranges and 2 metadata columns: #>       seqnames              ranges strand |         exon_id exon_rank #>          <Rle>           <IRanges>  <Rle> |     <character> <integer> #>   [1]        2 111120914-111121188      + | ENSE00004011574         1 #>   [2]        2 111123733-111124139      + | ENSE00001008808         2 #>   [3]        2 111150044-111150147      + | ENSE00003483971         3 #>   [4]        2 111164133-111168444      + | ENSE00001924953         4 #>   ------- #>   seqinfo: 1 sequence from GRCh38 genome bcl2l11_tbl <-     bcl2l11 |>     dplyr::as_tibble() |>     dplyr::mutate(CHROM = paste0(\"chr\", seqnames)) |>     dplyr::select(CHROM, everything(), -seqnames)  db_temporary_table(db_rw, bcl2l11_tbl, \"bcl2l11\") #> # Source:   table<bcl2l11> [4 x 9] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>   CHROM group group_name          start       end width strand exon_id exon_rank #>   <chr> <int> <chr>               <int>     <int> <int> <fct>  <chr>       <int> #> 1 chr2      1 ENST00000393256 111120914 111121188   275 +      ENSE00…         1 #> 2 chr2      1 ENST00000393256 111123733 111124139   407 +      ENSE00…         2 #> 3 chr2      1 ENST00000393256 111150044 111150147   104 +      ENSE00…         3 #> 4 chr2      1 ENST00000393256 111164133 111168444  4312 +      ENSE00…         4 \"bcl2l11\" %in% db_tables(db_rw) #> [1] TRUE rng <- db_range_join(db_rw, \"hg38\", \"bcl2l11\", \"bcl2l11_overlaps\") rng #> # Source:   table<bcl2l11_overlaps> [?? x 18] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>    CHROM       POS REF   ALT   genome uniprot_id transcript_id   protein_variant #>    <chr>     <dbl> <chr> <chr> <chr>  <chr>      <chr>           <chr>           #>  1 chr2  111164133 G     A     hg38   O43521     ENST0000039325… V167I           #>  2 chr2  111164133 G     T     hg38   O43521     ENST0000039325… V167L           #>  3 chr2  111164133 G     C     hg38   O43521     ENST0000039325… V167L           #>  4 chr2  111164134 T     C     hg38   O43521     ENST0000039325… V167A           #>  5 chr2  111164134 T     A     hg38   O43521     ENST0000039325… V167E           #>  6 chr2  111164134 T     G     hg38   O43521     ENST0000039325… V167G           #>  7 chr2  111164136 T     A     hg38   O43521     ENST0000039325… F168I           #>  8 chr2  111164136 T     C     hg38   O43521     ENST0000039325… F168L           #>  9 chr2  111164136 T     G     hg38   O43521     ENST0000039325… F168V           #> 10 chr2  111164137 T     G     hg38   O43521     ENST0000039325… F168C           #> # ℹ more rows #> # ℹ 10 more variables: am_pathogenicity <dbl>, am_class <chr>, group <int>, #> #   group_name <chr>, start <int>, end <int>, width <int>, strand <fct>, #> #   exon_id <chr>, exon_rank <int> rng |>     dplyr::count(exon_id, am_class) |>     tidyr::pivot_wider(names_from = \"am_class\", values_from = \"n\") #> # Source:   SQL [3 x 4] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>   exon_id         likely_benign likely_pathogenic ambiguous #>   <chr>                   <dbl>             <dbl>     <dbl> #> 1 ENSE00003483971           128                71        33 #> 2 ENSE00001008808           494               257       108 #> 3 ENSE00001924953           172                16        19 -- range join of 'hg38' with 'bcl2l11'; overwrite any existing table -- 'bcl2l11_overlaps' DROP TABLE IF EXISTS bcl2l11_overlaps; CREATE TEMP TABLE bcl2l11_overlaps AS SELECT     hg38.*,     bcl2l11.* EXCLUDE (CHROM) FROM hg38 JOIN bcl2l11     ON bcl2l11.CHROM = hg38.CHROM     AND bcl2l11.start <= hg38.POS     AND bcl2l11.end >= hg38.POS; db_disconnect(db_rw)"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"from-duckdb-to-bioconductor","dir":"Articles","previous_headings":"Working with Bioconductor","what":"From DuckDB to Bioconductor","title":"A. Introduction","text":"likely straight-forward ways performing query previous section, e.g., filtering hg38 relevant transcript id(s), retrieving R, working edb classify variants exon. transcript interested \"ENST00000393256\". Select relevant variants , many, load R. Coerce AlphaMissense data GRanges::GPos object. One can use GenomicRanges functionality, e.g., count number variants exon.","code":"variants_of_interest <-     am_data(\"hg38\") |>     dplyr::filter(transcript_id %like% \"ENST00000393256%\") gpos <-     variants_of_interest |>     to_GPos() ## make gpos 'genome' and 'seqlevels' like bcl2l11 GenomeInfoDb::genome(gpos) <- \"GRCh38\" GenomeInfoDb::seqlevelsStyle(gpos) <- \"Ensembl\" gpos #> UnstitchedGPos object with 1298 positions and 7 metadata columns: #>          seqnames       pos strand |         REF         ALT  uniprot_id #>             <Rle> <integer>  <Rle> | <character> <character> <character> #>      [1]        2 111123749      * |           G           C      O43521 #>      [2]        2 111123749      * |           G           T      O43521 #>      [3]        2 111123749      * |           G           A      O43521 #>      [4]        2 111123750      * |           C           A      O43521 #>      [5]        2 111123750      * |           C           G      O43521 #>      ...      ...       ...    ... .         ...         ...         ... #>   [1294]        2 111164227      * |           A           G      O43521 #>   [1295]        2 111164227      * |           A           T      O43521 #>   [1296]        2 111164227      * |           A           C      O43521 #>   [1297]        2 111164228      * |           T           A      O43521 #>   [1298]        2 111164228      * |           T           G      O43521 #>              transcript_id protein_variant am_pathogenicity          am_class #>                <character>     <character>        <numeric>       <character> #>      [1] ENST00000393256.8             A2P           0.6610 likely_pathogenic #>      [2] ENST00000393256.8             A2S           0.3398     likely_benign #>      [3] ENST00000393256.8             A2T           0.7219 likely_pathogenic #>      [4] ENST00000393256.8             A2E           0.7283 likely_pathogenic #>      [5] ENST00000393256.8             A2G           0.3883         ambiguous #>      ...               ...             ...              ...               ... #>   [1294] ENST00000393256.8           H198R           0.1226     likely_benign #>   [1295] ENST00000393256.8           H198L           0.2526     likely_benign #>   [1296] ENST00000393256.8           H198P           0.1323     likely_benign #>   [1297] ENST00000393256.8           H198Q           0.1781     likely_benign #>   [1298] ENST00000393256.8           H198Q           0.1781     likely_benign #>   ------- #>   seqinfo: 25 sequences (1 circular) from GRCh38 genome countOverlaps(unlist(bcl2l11), gpos) #> ENST00000393256 ENST00000393256 ENST00000393256 ENST00000393256  #>               0             859             232             207"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"finally","dir":"Articles","previous_headings":"","what":"Finally","title":"A. Introduction","text":"Remember disconnect shutdown managed DuckDB connections. Database connections closed correctly trigger warning messages.","code":"db_disconnect_all()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"session-information","dir":"Articles","previous_headings":"","what":"Session information","title":"A. Introduction","text":"","code":"sessionInfo() #> R version 4.4.1 Patched (2024-06-20 r86819) #> Platform: aarch64-apple-darwin23.5.0 #> Running under: macOS Sonoma 14.5 #>  #> Matrix products: default #> BLAS:   /Users/ma38727/bin/R-4-4-branch/lib/libRblas.dylib  #> LAPACK: /Users/ma38727/bin/R-4-4-branch/lib/libRlapack.dylib;  LAPACK version 3.12.0 #>  #> locale: #> [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 #>  #> time zone: America/New_York #> tzcode source: internal #>  #> attached base packages: #> [1] stats4    stats     graphics  grDevices utils     datasets  methods   #> [8] base      #>  #> other attached packages: #>  [1] ensembldb_2.29.0        AnnotationFilter_1.29.0 GenomicFeatures_1.57.0  #>  [4] AnnotationDbi_1.67.0    Biobase_2.65.0          GenomicRanges_1.57.1    #>  [7] GenomeInfoDb_1.41.1     IRanges_2.39.0          S4Vectors_0.43.0        #> [10] BiocGenerics_0.51.0     AlphaMissenseR_1.1.5    dplyr_1.1.4             #>  #> loaded via a namespace (and not attached): #>  [1] DBI_1.2.3                   bitops_1.0-7                #>  [3] rlang_1.1.4                 magrittr_2.0.3              #>  [5] matrixStats_1.3.0           compiler_4.4.1              #>  [7] RSQLite_2.3.7               png_0.1-8                   #>  [9] systemfonts_1.1.0           vctrs_0.6.5                 #> [11] ProtGenerics_1.37.0         pkgconfig_2.0.3             #> [13] crayon_1.5.3                fastmap_1.2.0               #> [15] dbplyr_2.5.0                XVector_0.45.0              #> [17] utf8_1.2.4                  Rsamtools_2.21.0            #> [19] rmarkdown_2.27              UCSC.utils_1.1.0            #> [21] ragg_1.3.2                  purrr_1.0.2                 #> [23] bit_4.0.5                   xfun_0.45                   #> [25] zlibbioc_1.51.1             cachem_1.1.0                #> [27] jsonlite_1.8.8              blob_1.2.4                  #> [29] DelayedArray_0.31.3         BiocParallel_1.39.0         #> [31] parallel_4.4.1              spdl_0.0.5                  #> [33] R6_2.5.1                    bslib_0.7.0                 #> [35] rtracklayer_1.65.0          jquerylib_0.1.4             #> [37] Rcpp_1.0.12                 SummarizedExperiment_1.35.0 #> [39] knitr_1.47                  BiocBaseUtils_1.7.0         #> [41] Matrix_1.7-0                tidyselect_1.2.1            #> [43] abind_1.4-5                 yaml_2.3.8                  #> [45] codetools_0.2-20            curl_5.2.1                  #> [47] rjsoncons_1.3.0             lattice_0.22-6              #> [49] tibble_3.2.1                withr_3.0.0                 #> [51] KEGGREST_1.45.1             evaluate_0.24.0             #> [53] desc_1.4.3                  BiocFileCache_2.13.0        #> [55] Biostrings_2.73.1           pillar_1.9.0                #> [57] BiocManager_1.30.23         filelock_1.0.3              #> [59] MatrixGenerics_1.17.0       whisker_0.4.1               #> [61] generics_0.1.3              RCurl_1.98-1.14             #> [63] BiocVersion_3.20.0          ggplot2_3.5.1               #> [65] munsell_0.5.1               scales_1.3.0                #> [67] glue_1.7.0                  lazyeval_0.2.2              #> [69] tools_4.4.1                 AnnotationHub_3.13.0        #> [71] BiocIO_1.15.0               GenomicAlignments_1.41.0    #> [73] fs_1.6.4                    XML_3.99-0.17               #> [75] grid_4.4.1                  tidyr_1.3.1                 #> [77] colorspace_2.1-0            GenomeInfoDbData_1.2.12     #> [79] RcppSpdlog_0.0.17           duckdb_1.0.0                #> [81] restfulr_0.0.15             cli_3.6.3                   #> [83] rappdirs_0.3.3              textshaping_0.4.0           #> [85] fansi_1.0.6                 S4Arrays_1.5.1              #> [87] gtable_0.3.5                sass_0.4.9                  #> [89] digest_0.6.36               SparseArray_1.5.10          #> [91] rjson_0.2.21                htmlwidgets_1.6.4           #> [93] memoise_2.0.1               htmltools_0.5.8.1           #> [95] pkgdown_2.0.9               lifecycle_1.0.4             #> [97] httr_1.4.7                  mime_0.12                   #> [99] bit64_4.0.5"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/issues.html","id":"updating-duckdb-to-0-9-1","dir":"Articles","previous_headings":"","what":"Updating duckdb to 0.9.1","title":"D. Issues & Solutions","text":"R duckdb client version 0.9.1 read databases created previous versions package. duckdb error message indicates am_available() Error h(simpleError(msg, call)) : error evaluating argument ‘drv’ selecting method function ‘dbConnect’: rapi_startup: Failed open database: IO Error: Trying read database file version number 51, can read version 64. database file created DuckDB version v0.8.0 v0.8.1. storage DuckDB yet stable; newer versions DuckDB read old database files vice versa. storage stabilized version 1.0 releases. now, recommend load database file supported version DuckDB, use EXPORT DATABASE command followed IMPORT DATABASE current version DuckDB. See storage page information: https://duckdb.org/internals/storage practice straight-forward solution remove existing AlphaMissenseR data resources ‘start ’. following attempts identify AlphaMissenseR data resources cached locally verifying resources created outside AlphaMissenseR, remove . Commands am_available() report files cached. command re-download file insert database functions duckdb 0.9.1.","code":"am_rids <-     bfcinfo() |>     dplyr::filter(         grepl(\"zenodo\", rname) |         startsWith(rname, \"AlphaMissense_\")     ) |>     pull(rid) BiocFileCache::bfcremove(rids = am_rids) am_data(\"gene_hg38\") #> # Source:   table<gene_hg38> [?? x 2] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>    transcript_id      mean_am_pathogenicity #>    <chr>                              <dbl> #>  1 ENST00000000233.10                 0.742 #>  2 ENST00000000412.8                  0.378 #>  3 ENST00000001008.6                  0.422 #>  4 ENST00000001146.6                  0.467 #>  5 ENST00000002125.9                  0.351 #>  6 ENST00000002165.11                 0.406 #>  7 ENST00000002501.10                 0.320 #>  8 ENST00000002596.6                  0.471 #>  9 ENST00000002829.8                  0.524 #> 10 ENST00000003084.10                 0.405 #> # ℹ more rows"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/issues.html","id":"resource-temporarily-unavailable","dir":"Articles","previous_headings":"","what":"Resource temporarily unavailable","title":"D. Issues & Solutions","text":"Trying access data resource am_data() may sometimes result DuckDB errors “Resource unavailable”. occures database used independent R process. solution identify process disconnect database using, e.g., db_disconnect_all().","code":"> am_data(\"hg38\")  * [10:05:09][warning] error in evaluating the argument 'drv' in selecting a     method for function 'dbConnect': rapi_startup: Failed to open database:     IO Error: Could not set lock on file      \".../Caches/org.R-project.R/R/BiocFileCache/1ec5157ddaa2_1ec5157ddaa2\":     Resource unavailable  Error in value[[3L]](cond) :     failed to connect to DuckDB database, see 'Issues & Solutions' vignette"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/issues.html","id":"finally","dir":"Articles","previous_headings":"","what":"Finally","title":"D. Issues & Solutions","text":"Remember disconnect shutdown managed DuckDB connections. Database connections closed correctly trigger warning messages.","code":"db_disconnect_all()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/issues.html","id":"session-information","dir":"Articles","previous_headings":"","what":"Session information","title":"D. Issues & Solutions","text":"","code":"sessionInfo() #> R version 4.4.1 Patched (2024-06-20 r86819) #> Platform: aarch64-apple-darwin23.5.0 #> Running under: macOS Sonoma 14.5 #>  #> Matrix products: default #> BLAS:   /Users/ma38727/bin/R-4-4-branch/lib/libRblas.dylib  #> LAPACK: /Users/ma38727/bin/R-4-4-branch/lib/libRlapack.dylib;  LAPACK version 3.12.0 #>  #> locale: #> [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 #>  #> time zone: America/New_York #> tzcode source: internal #>  #> attached base packages: #> [1] stats     graphics  grDevices utils     datasets  methods   base      #>  #> other attached packages: #> [1] AlphaMissenseR_1.1.5 dplyr_1.1.4          #>  #> loaded via a namespace (and not attached): #>  [1] sass_0.4.9           utf8_1.2.4           generics_0.1.3       #>  [4] spdl_0.0.5           RSQLite_2.3.7        digest_0.6.36        #>  [7] magrittr_2.0.3       evaluate_0.24.0      grid_4.4.1           #> [10] fastmap_1.2.0        blob_1.2.4           jsonlite_1.8.8       #> [13] whisker_0.4.1        DBI_1.2.3            httr_1.4.7           #> [16] purrr_1.0.2          fansi_1.0.6          scales_1.3.0         #> [19] textshaping_0.4.0    jquerylib_0.1.4      duckdb_1.0.0         #> [22] cli_3.6.3            rlang_1.1.4          dbplyr_2.5.0         #> [25] bit64_4.0.5          munsell_0.5.1        withr_3.0.0          #> [28] cachem_1.1.0         yaml_2.3.8           BiocBaseUtils_1.7.0  #> [31] tools_4.4.1          memoise_2.0.1        colorspace_2.1-0     #> [34] ggplot2_3.5.1        filelock_1.0.3       curl_5.2.1           #> [37] rjsoncons_1.3.0      vctrs_0.6.5          R6_2.5.1             #> [40] BiocFileCache_2.13.0 lifecycle_1.0.4      RcppSpdlog_0.0.17    #> [43] fs_1.6.4             htmlwidgets_1.6.4    bit_4.0.5            #> [46] ragg_1.3.2           pkgconfig_2.0.3      desc_1.4.3           #> [49] pkgdown_2.0.9        pillar_1.9.0         bslib_0.7.0          #> [52] gtable_0.3.5         Rcpp_1.0.12          glue_1.7.0           #> [55] systemfonts_1.1.0    xfun_0.45            tibble_3.2.1         #> [58] tidyselect_1.2.1     knitr_1.47           htmltools_0.5.8.1    #> [61] rmarkdown_2.27       compiler_4.4.1"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Martin Morgan. Author, maintainer. Tram Nguyen. Author. Chan Zuckerberg Initiative DAF CZF2019-002443. Funder. NIH NCI ITCR U24CA180996. Funder. NIH NCI IOTN U24CA232979. Funder. NIH NCI ARTNet U24CA274159. Funder.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Morgan M, Nguyen T (2024). AlphaMissenseR: Accessing AlphaMissense Data Resources R. R package version 1.1.5, https://mtmorgan.github.io/AlphaMissenseR/.","code":"@Manual{,   title = {AlphaMissenseR: Accessing AlphaMissense Data Resources in R},   author = {Martin Morgan and Tram Nguyen},   year = {2024},   note = {R package version 1.1.5},   url = {https://mtmorgan.github.io/AlphaMissenseR/}, }"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/index.html","id":"alphamissense-data-for-r--bioconductor","dir":"","previous_headings":"","what":"Accessing AlphaMissense Data Resources in R","title":"Accessing AlphaMissense Data Resources in R","text":"AlphaMissense publication outlines variant AlphaFold / DeepMind used predict missense variant pathogenicity. Supporting data Zenodo include, instance 70+M variants across hg19 hg38 genome builds. AlphaMissense package allows ready access data, downloading individual files DuckDB databases ready exploration integration R Bioconductor worksflows.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"Accessing AlphaMissense Data Resources in R","text":"Install package Bioconductor GitHub, ensuring correct Bioconductor dependencies. package available Bioconductor, use Use pre-release devel version Load library.","code":"if (!\"BiocManager\" %in% rownames(installed.packages()))     install.packages(\"BiocManager\", repos = \"https://cloud.R-project.org\") if (BiocManager::version() >= \"3.19\") {     BiocManager::install(\"AlphaMissenseR\") } else {     stop(         \"'AlphaMissenseR' requires Bioconductor version 3.19 or later, \",         \"install from GitHub?\"     ) } if (!\"remotes\" %in% rownames(installed.packages()))     install.packages(\"remotes\", repos = \"https://cloud.R-project.org\") remotes::install_github(     \"mtmorgan/AlphaMissenseR\",     repos = BiocManager::repositories() ) library(AlphaMissenseR)"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/index.html","id":"next-steps","dir":"","previous_headings":"","what":"Next steps","title":"Accessing AlphaMissense Data Resources in R","text":"Visit Introduction learn accessing AlphaMissense data R. AlphaFold Integration article shows missense effects can plotted AlphaFold () protein structures. Use ClinVar Integration compare AlphaMissense ClinVar predictions. Troubleshoot common problems Issues & Solutions.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html","id":null,"dir":"Reference","previous_headings":"","what":"AlphaFold Protein Structure Retrieval and Display — af_predictions","title":"AlphaFold Protein Structure Retrieval and Display — af_predictions","text":"af_predictions() retrieves information AlphaFold predictions associated UniProt accession identifiers. af_prediction_view() summarizes effects possible amino acid changes single UniProt protein. changes displayed AlphaFold-predicted structure. af_colorfunc_by_position() generates Javascript function used rd3mol::m_set_style() color residues position, e.g., visualizing median predicted pathogenicity.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"AlphaFold Protein Structure Retrieval and Display — af_predictions","text":"","code":"af_predictions(uniprot_ids)  af_prediction_view(tbl, bfc = BiocFileCache())  af_colorfunc_by_position(     tbl,     pos,     value,     pos_max = NULL,     palette = colorspace::diverging_hcl(11),     palette_min = NULL,     palette_max = NULL )"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"AlphaFold Protein Structure Retrieval and Display — af_predictions","text":"uniprot_ids character() UniProt accession identifiers (uniprot_id AlphaMissense tables). tbl tibble containing information UniProt protein AlphaMissense predicted amino acid effects. av_prediction_view() tibble must columns uniprot_id, protein_variant, am_pathogenicity, am_class, tibbles returned am_data(\"hg38\") am_data(\"aa_substitutions\"), instance. uniprot_id must contain single unique value. af_colorfunc_by_position() tibble must columns pos value, described . bfc object created BiocFileCache::BiocFileCache(), representing location used cache PDB files retrieved av_prediction_view(). default BiocFileCache installation-wide location. pos symbol name column tbl containing amino acid residue positions protein. value symbol name column tbl containing values used coloring amino acid residues protein. pos_max integer(1) maximum residue position protein visualized. Default: maximum value pos. palette character() vector colors used visualization. default (colorspace::diverging_hcl(11)) produces colors ranging blue (low) red (high). palette_min numeric(1) value bounding minimum palette color. default minimum value; common value plotting pathogenicity might 0. palette_max numeric(1) value bounding maximum palette color. default maximum value; common value plotting pathogenicity might 1.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"AlphaFold Protein Structure Retrieval and Display — af_predictions","text":"af_predictions() returns tibble. row represents AlphaFold prediction associated corresponding uniprot accession. Columns include: entryId: AlphaFold identifier. gene: gene symbol corresponding UniProt protein. uniprotAccession, uniprotId, uniprotDescription: UniProt characterization. AlphaMissense's uniprot_id AlphaFold's uniprotAccession. taxId, organismScientificName: Organism information. uniprotStart, uniprotEnd, uniprotSequence: protein sequence information. modelCreatedDate, latestVersion, allVersions, isReviewed, isReferenceProteome: AlphaFold provenance information. cifUrl, bcifUrl, pdbUrl: URLs AlphaFold 3-dimensional molecular representations. paeImageUrl, paeDocUrl: 'Predicted Aligned Error' heat map underlying data. can used assess confidence relative orientation residues different domains, described part AlphaFold FAQ https://alphafold.ebi.ac.uk/faq af_prediction_view() displays interactive view protein RStudio panel browser tab. af_colorfunc_by_position() returns character(1) vector representation Javascript function, color vector injected.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"AlphaFold Protein Structure Retrieval and Display — af_predictions","text":"af_predictions() queries prediction endpoint AlphaFold API described https://alphafold.ebi.ac.uk/api-docs. af_prediction_view() uses tbl calculate median pathogenicity amino acid position, using am_aa_pathogenicity(). Predicted protein structure retrieved unique uniprot_id using af_predictions() pdbUrl returned function. Protein structure visualized using r3dmol https://cran.R-project.org/package=r3dmol package. Amino acids colored using aa_pathogenicity_median af_colorfunc_by_position() default palette defined interval 0, 1. af_colorfunc_by_position() uses template mechanism inject vector position-specific colors Javascript function used r3dmol::m_set_style() / r3dmol::m_style_cartoon() color residues position. Positions color specified colored 'gray'. template can seen AlphaMissenseR:::js_template(\"colorfunc\").","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"AlphaFold Protein Structure Retrieval and Display — af_predictions","text":"","code":"## af_predictions  uniprot_ids <-     am_data(\"aa_substitutions\") |>     dplyr::filter(uniprot_id %like% \"P3555%\") |>     dplyr::distinct(uniprot_id) |>     pull(uniprot_id) af_predictions(uniprot_ids) #> * [14:04:32][info] 2 of 4 uniprot accessions not found #>   'P35555', 'P35556' #> # A tibble: 2 × 23 #>   entryId      gene  uniprotAccession uniprotId   uniprotDescription       taxId #>   <chr>        <chr> <chr>            <chr>       <chr>                    <int> #> 1 AF-P35557-F1 GCK   P35557           HXK4_HUMAN  Hexokinase-4              9606 #> 2 AF-P35558-F1 PCK1  P35558           PCKGC_HUMAN Phosphoenolpyruvate car…  9606 #> # ℹ 17 more variables: organismScientificName <chr>, uniprotStart <int>, #> #   uniprotEnd <int>, uniprotSequence <chr>, modelCreatedDate <chr>, #> #   latestVersion <int>, allVersions <list>, isReviewed <lgl>, #> #   isReferenceProteome <lgl>, cifUrl <chr>, bcifUrl <chr>, pdbUrl <chr>, #> #   paeImageUrl <chr>, paeDocUrl <chr>, amAnnotationsUrl <chr>, #> #   amAnnotationsHg19Url <chr>, amAnnotationsHg38Url <chr>   ## af_prediction_view()  P35557 <-     am_data(\"hg38\") |>     dplyr::filter(uniprot_id == \"P35557\") af_prediction_view(P35557)  {\"x\":{\"id\":\"ac96cb3ee4656e2e9ec3\",\"configs\":{\"nomouse\":false,\"backgroundColor\":\"white\",\"cartoonQuality\":5,\"lowerZoomLimit\":5,\"upperZoomLimit\":400,\"antialias\":true,\"orthographic\":false,\"disableFog\":false},\"api\":[{\"method\":\"addModel\",\"data\":[\"ATOM      1  N   MET A   1      37.762  17.693 -31.307  1.00 60.70           N  \\nATOM      2  CA  MET A   1      37.985  16.974 -30.030  1.00 60.70           C  \\nATOM      3  C   MET A   1      37.126  17.503 -28.884  1.00 60.70           C  \\nATOM      4  CB  MET A   1      39.461  16.796 -29.632  1.00 60.70           C  \\nATOM      5  O   MET A   1      36.269  16.755 -28.443  1.00 60.70           O  \\nATOM      6  CG  MET A   1      40.135  15.744 -30.527  1.00 60.70           C  \\nATOM      7  SD  MET A   1      41.521  14.854 -29.765  1.00 60.70           S  \\nATOM      8  CE  MET A   1      42.862  16.064 -29.883  1.00 60.70           C  \\nATOM      9  N   LEU A   2      37.301  18.742 -28.389  1.00 66.32           N  \\nATOM     10  CA  LEU A   2      36.431  19.268 -27.311  1.00 66.32           C  \\nATOM     11  C   LEU A   2      34.963  19.419 -27.754  1.00 66.32           C  \\nATOM     12  CB  LEU A   2      36.978  20.607 -26.772  1.00 66.32           C  \\nATOM     13  O   LEU A   2      34.069  19.025 -27.014  1.00 66.32           O  \\nATOM     14  CG  LEU A   2      38.201  20.479 -25.844  1.00 66.32           C  \\nATOM     15  CD1 LEU A   2      38.800  21.861 -25.582  1.00 66.32           C  \\nATOM     16  CD2 LEU A   2      37.846  19.854 -24.492  1.00 66.32           C  \\nATOM     17  N   ASP A   3      34.733  19.913 -28.976  1.00 78.24           N  \\nATOM     18  CA  ASP A   3      33.388  20.032 -29.565  1.00 78.24           C  \\nATOM     19  C   ASP A   3      32.722  18.652 -29.737  1.00 78.24           C  \\nATOM     20  CB  ASP A   3      33.514  20.801 -30.895  1.00 78.24           C  \\nATOM     21  O   ASP A   3      31.591  18.446 -29.312  1.00 78.24           O  \\nATOM     22  CG  ASP A   3      32.176  21.209 -31.531  1.00 78.24           C  \\nATOM     23  OD1 ASP A   3      31.128  21.192 -30.857  1.00 78.24           O  \\nATOM     24  OD2 ASP A   3      32.176  21.545 -32.735  1.00 78.24           O  \\nATOM     25  N   ASP A   4      33.462  17.654 -30.235  1.00 81.51           N  \\nATOM     26  CA  ASP A   4      32.934  16.293 -30.417  1.00 81.51           C  \\nATOM     27  C   ASP A   4      32.518  15.647 -29.089  1.00 81.51           C  \\nATOM     28  CB  ASP A   4      33.964  15.398 -31.121  1.00 81.51           C  \\nATOM     29  O   ASP A   4      31.462  15.023 -29.009  1.00 81.51           O  \\nATOM     30  CG  ASP A   4      34.515  16.040 -32.390  1.00 81.51           C  \\nATOM     31  OD1 ASP A   4      33.711  16.482 -33.231  1.00 81.51           O  \\nATOM     32  OD2 ASP A   4      35.761  16.218 -32.427  1.00 81.51           O  \\nATOM     33  N   ARG A   5      33.312  15.823 -28.023  1.00 79.75           N  \\nATOM     34  CA  ARG A   5      32.974  15.294 -26.694  1.00 79.75           C  \\nATOM     35  C   ARG A   5      31.726  15.960 -26.119  1.00 79.75           C  \\nATOM     36  CB  ARG A   5      34.178  15.412 -25.751  1.00 79.75           C  \\nATOM     37  O   ARG A   5      30.853  15.255 -25.625  1.00 79.75           O  \\nATOM     38  CG  ARG A   5      33.856  14.778 -24.392  1.00 79.75           C  \\nATOM     39  CD  ARG A   5      35.055  14.843 -23.452  1.00 79.75           C  \\nATOM     40  NE  ARG A   5      34.650  14.406 -22.113  1.00 79.75           N  \\nATOM     41  NH1 ARG A   5      36.721  14.355 -21.118  1.00 79.75           N  \\nATOM     42  NH2 ARG A   5      34.868  13.787 -19.975  1.00 79.75           N  \\nATOM     43  CZ  ARG A   5      35.425  14.182 -21.077  1.00 79.75           C  \\nATOM     44  N   ALA A   6      31.626  17.286 -26.219  1.00 82.64           N  \\nATOM     45  CA  ALA A   6      30.450  18.018 -25.756  1.00 82.64           C  \\nATOM     46  C   ALA A   6      29.185  17.595 -26.522  1.00 82.64           C  \\nATOM     47  CB  ALA A   6      30.727  19.518 -25.899  1.00 82.64           C  \\nATOM     48  O   ALA A   6      28.138  17.389 -25.913  1.00 82.64           O  \\nATOM     49  N   ARG A   7      29.291  17.387 -27.843  1.00 85.02           N  \\nATOM     50  CA  ARG A   7      28.191  16.868 -28.670  1.00 85.02           C  \\nATOM     51  C   ARG A   7      27.776  15.453 -28.266  1.00 85.02           C  \\nATOM     52  CB  ARG A   7      28.583  16.907 -30.151  1.00 85.02           C  \\nATOM     53  O   ARG A   7      26.583  15.187 -28.172  1.00 85.02           O  \\nATOM     54  CG  ARG A   7      28.633  18.335 -30.709  1.00 85.02           C  \\nATOM     55  CD  ARG A   7      29.134  18.280 -32.151  1.00 85.02           C  \\nATOM     56  NE  ARG A   7      29.458  19.619 -32.661  1.00 85.02           N  \\nATOM     57  NH1 ARG A   7      29.195  19.167 -34.898  1.00 85.02           N  \\nATOM     58  NH2 ARG A   7      29.938  21.162 -34.242  1.00 85.02           N  \\nATOM     59  CZ  ARG A   7      29.515  19.979 -33.927  1.00 85.02           C  \\nATOM     60  N   MET A   8      28.731  14.563 -27.991  1.00 84.70           N  \\nATOM     61  CA  MET A   8      28.434  13.203 -27.522  1.00 84.70           C  \\nATOM     62  C   MET A   8      27.769  13.195 -26.138  1.00 84.70           C  \\nATOM     63  CB  MET A   8      29.709  12.349 -27.495  1.00 84.70           C  \\nATOM     64  O   MET A   8      26.806  12.462 -25.934  1.00 84.70           O  \\nATOM     65  CG  MET A   8      30.181  11.952 -28.899  1.00 84.70           C  \\nATOM     66  SD  MET A   8      31.588  10.802 -28.930  1.00 84.70           S  \\nATOM     67  CE  MET A   8      32.896  11.823 -28.208  1.00 84.70           C  \\nATOM     68  N   GLU A   9      28.237  14.020 -25.196  1.00 85.54           N  \\nATOM     69  CA  GLU A   9      27.622  14.147 -23.865  1.00 85.54           C  \\nATOM     70  C   GLU A   9      26.205  14.746 -23.944  1.00 85.54           C  \\nATOM     71  CB  GLU A   9      28.535  14.970 -22.929  1.00 85.54           C  \\nATOM     72  O   GLU A   9      25.303  14.277 -23.248  1.00 85.54           O  \\nATOM     73  CG  GLU A   9      29.768  14.174 -22.443  1.00 85.54           C  \\nATOM     74  CD  GLU A   9      30.755  14.978 -21.563  1.00 85.54           C  \\nATOM     75  OE1 GLU A   9      31.864  14.443 -21.269  1.00 85.54           O  \\nATOM     76  OE2 GLU A   9      30.443  16.135 -21.210  1.00 85.54           O  \\nATOM     77  N   ALA A  10      25.976  15.720 -24.833  1.00 88.64           N  \\nATOM     78  CA  ALA A  10      24.648  16.280 -25.085  1.00 88.64           C  \\nATOM     79  C   ALA A  10      23.686  15.241 -25.686  1.00 88.64           C  \\nATOM     80  CB  ALA A  10      24.789  17.515 -25.982  1.00 88.64           C  \\nATOM     81  O   ALA A  10      22.583  15.072 -25.170  1.00 88.64           O  \\nATOM     82  N   ALA A  11      24.125  14.491 -26.703  1.00 91.48           N  \\nATOM     83  CA  ALA A  11      23.331  13.423 -27.315  1.00 91.48           C  \\nATOM     84  C   ALA A  11      23.015  12.292 -26.319  1.00 91.48           C  \\nATOM     85  CB  ALA A  11      24.099  12.894 -28.532  1.00 91.48           C  \\nATOM     86  O   ALA A  11      21.897  11.779 -26.285  1.00 91.48           O  \\nATOM     87  N   LYS A  12      23.980  11.934 -25.456  1.00 91.93           N  \\nATOM     88  CA  LYS A  12      23.772  10.989 -24.350  1.00 91.93           C  \\nATOM     89  C   LYS A  12      22.669  11.483 -23.412  1.00 91.93           C  \\nATOM     90  CB  LYS A  12      25.108  10.761 -23.614  1.00 91.93           C  \\nATOM     91  O   LYS A  12      21.759  10.724 -23.093  1.00 91.93           O  \\nATOM     92  CG  LYS A  12      24.963   9.814 -22.416  1.00 91.93           C  \\nATOM     93  CD  LYS A  12      26.284   9.567 -21.671  1.00 91.93           C  \\nATOM     94  CE  LYS A  12      25.910   8.628 -20.526  1.00 91.93           C  \\nATOM     95  NZ  LYS A  12      27.026   8.112 -19.694  1.00 91.93           N  \\nATOM     96  N   LYS A  13      22.736  12.747 -22.984  1.00 92.69           N  \\nATOM     97  CA  LYS A  13      21.739  13.346 -22.086  1.00 92.69           C  \\nATOM     98  C   LYS A  13      20.345  13.381 -22.715  1.00 92.69           C  \\nATOM     99  CB  LYS A  13      22.216  14.743 -21.667  1.00 92.69           C  \\nATOM    100  O   LYS A  13      19.381  13.041 -22.043  1.00 92.69           O  \\nATOM    101  CG  LYS A  13      21.267  15.361 -20.633  1.00 92.69           C  \\nATOM    102  CD  LYS A  13      21.762  16.734 -20.177  1.00 92.69           C  \\nATOM    103  CE  LYS A  13      20.733  17.298 -19.195  1.00 92.69           C  \\nATOM    104  NZ  LYS A  13      21.122  18.638 -18.700  1.00 92.69           N  \\nATOM    105  N   GLU A  14      20.245  13.753 -23.988  1.00 94.75           N  \\nATOM    106  CA  GLU A  14      18.976  13.773 -24.724  1.00 94.75           C  \\nATOM    107  C   GLU A  14      18.333  12.382 -24.778  1.00 94.75           C  \\nATOM    108  CB  GLU A  14      19.245  14.333 -26.127  1.00 94.75           C  \\nATOM    109  O   GLU A  14      17.157  12.237 -24.454  1.00 94.75           O  \\nATOM    110  CG  GLU A  14      17.969  14.520 -26.962  1.00 94.75           C  \\nATOM    111  CD  GLU A  14      18.247  15.162 -28.333  1.00 94.75           C  \\nATOM    112  OE1 GLU A  14      17.259  15.447 -29.045  1.00 94.75           O  \\nATOM    113  OE2 GLU A  14      19.436  15.386 -28.664  1.00 94.75           O  \\nATOM    114  N   LYS A  15      19.119  11.342 -25.083  1.00 96.79           N  \\nATOM    115  CA  LYS A  15      18.615   9.965 -25.139  1.00 96.79           C  \\nATOM    116  C   LYS A  15      18.205   9.422 -23.764  1.00 96.79           C  \\nATOM    117  CB  LYS A  15      19.659   9.083 -25.833  1.00 96.79           C  \\nATOM    118  O   LYS A  15      17.219   8.698 -23.669  1.00 96.79           O  \\nATOM    119  CG  LYS A  15      19.039   7.759 -26.297  1.00 96.79           C  \\nATOM    120  CD  LYS A  15      20.049   6.938 -27.107  1.00 96.79           C  \\nATOM    121  CE  LYS A  15      19.474   5.553 -27.397  1.00 96.79           C  \\nATOM    122  NZ  LYS A  15      20.485   4.644 -27.983  1.00 96.79           N  \\nATOM    123  N   VAL A  16      18.922   9.792 -22.698  1.00 97.86           N  \\nATOM    124  CA  VAL A  16      18.512   9.475 -21.318  1.00 97.86           C  \\nATOM    125  C   VAL A  16      17.164  10.119 -21.001  1.00 97.86           C  \\nATOM    126  CB  VAL A  16      19.572   9.912 -20.288  1.00 97.86           C  \\nATOM    127  O   VAL A  16      16.260   9.426 -20.548  1.00 97.86           O  \\nATOM    128  CG1 VAL A  16      19.068   9.804 -18.842  1.00 97.86           C  \\nATOM    129  CG2 VAL A  16      20.837   9.051 -20.388  1.00 97.86           C  \\nATOM    130  N   GLU A  17      16.999  11.419 -21.260  1.00 97.61           N  \\nATOM    131  CA  GLU A  17      15.728  12.103 -20.983  1.00 97.61           C  \\nATOM    132  C   GLU A  17      14.587  11.564 -21.858  1.00 97.61           C  \\nATOM    133  CB  GLU A  17      15.868  13.625 -21.141  1.00 97.61           C  \\nATOM    134  O   GLU A  17      13.459  11.505 -21.386  1.00 97.61           O  \\nATOM    135  CG  GLU A  17      16.793  14.298 -20.104  1.00 97.61           C  \\nATOM    136  CD  GLU A  17      16.328  14.240 -18.629  1.00 97.61           C  \\nATOM    137  OE1 GLU A  17      17.206  14.199 -17.734  1.00 97.61           O  \\nATOM    138  OE2 GLU A  17      15.119  14.354 -18.324  1.00 97.61           O  \\nATOM    139  N   GLN A  18      14.861  11.099 -23.082  1.00 97.55           N  \\nATOM    140  CA  GLN A  18      13.860  10.435 -23.920  1.00 97.55           C  \\nATOM    141  C   GLN A  18      13.335   9.136 -23.288  1.00 97.55           C  \\nATOM    142  CB  GLN A  18      14.450  10.176 -25.315  1.00 97.55           C  \\nATOM    143  O   GLN A  18      12.127   8.924 -23.278  1.00 97.55           O  \\nATOM    144  CG  GLN A  18      13.397   9.607 -26.278  1.00 97.55           C  \\nATOM    145  CD  GLN A  18      13.946   9.282 -27.662  1.00 97.55           C  \\nATOM    146  NE2 GLN A  18      13.108   8.791 -28.548  1.00 97.55           N  \\nATOM    147  OE1 GLN A  18      15.115   9.435 -27.983  1.00 97.55           O  \\nATOM    148  N   ILE A  19      14.217   8.287 -22.745  1.00 98.10           N  \\nATOM    149  CA  ILE A  19      13.818   7.049 -22.050  1.00 98.10           C  \\nATOM    150  C   ILE A  19      13.058   7.390 -20.762  1.00 98.10           C  \\nATOM    151  CB  ILE A  19      15.062   6.167 -21.773  1.00 98.10           C  \\nATOM    152  O   ILE A  19      11.996   6.847 -20.481  1.00 98.10           O  \\nATOM    153  CG1 ILE A  19      15.640   5.633 -23.105  1.00 98.10           C  \\nATOM    154  CG2 ILE A  19      14.723   4.992 -20.835  1.00 98.10           C  \\nATOM    155  CD1 ILE A  19      17.038   5.015 -22.978  1.00 98.10           C  \\nATOM    156  N   LEU A  20      13.567   8.337 -19.974  1.00 98.38           N  \\nATOM    157  CA  LEU A  20      12.933   8.711 -18.708  1.00 98.38           C  \\nATOM    158  C   LEU A  20      11.607   9.469 -18.895  1.00 98.38           C  \\nATOM    159  CB  LEU A  20      13.935   9.504 -17.858  1.00 98.38           C  \\nATOM    160  O   LEU A  20      10.766   9.454 -17.995  1.00 98.38           O  \\nATOM    161  CG  LEU A  20      15.193   8.714 -17.441  1.00 98.38           C  \\nATOM    162  CD1 LEU A  20      16.049   9.599 -16.539  1.00 98.38           C  \\nATOM    163  CD2 LEU A  20      14.874   7.425 -16.684  1.00 98.38           C  \\nATOM    164  N   ALA A  21      11.383  10.096 -20.054  1.00 97.79           N  \\nATOM    165  CA  ALA A  21      10.121  10.750 -20.391  1.00 97.79           C  \\nATOM    166  C   ALA A  21       8.939   9.770 -20.467  1.00 97.79           C  \\nATOM    167  CB  ALA A  21      10.278  11.535 -21.698  1.00 97.79           C  \\nATOM    168  O   ALA A  21       7.809  10.195 -20.246  1.00 97.79           O  \\nATOM    169  N   GLU A  22       9.175   8.470 -20.686  1.00 97.70           N  \\nATOM    170  CA  GLU A  22       8.130   7.432 -20.664  1.00 97.70           C  \\nATOM    171  C   GLU A  22       7.412   7.350 -19.305  1.00 97.70           C  \\nATOM    172  CB  GLU A  22       8.753   6.063 -20.988  1.00 97.70           C  \\nATOM    173  O   GLU A  22       6.244   6.979 -19.228  1.00 97.70           O  \\nATOM    174  CG  GLU A  22       9.398   6.003 -22.382  1.00 97.70           C  \\nATOM    175  CD  GLU A  22      10.020   4.629 -22.687  1.00 97.70           C  \\nATOM    176  OE1 GLU A  22       9.765   4.133 -23.809  1.00 97.70           O  \\nATOM    177  OE2 GLU A  22      10.766   4.094 -21.830  1.00 97.70           O  \\nATOM    178  N   PHE A  23       8.089   7.739 -18.220  1.00 98.41           N  \\nATOM    179  CA  PHE A  23       7.521   7.754 -16.871  1.00 98.41           C  \\nATOM    180  C   PHE A  23       6.689   9.009 -16.572  1.00 98.41           C  \\nATOM    181  CB  PHE A  23       8.659   7.600 -15.852  1.00 98.41           C  \\nATOM    182  O   PHE A  23       6.019   9.075 -15.537  1.00 98.41           O  \\nATOM    183  CG  PHE A  23       9.287   6.222 -15.844  1.00 98.41           C  \\nATOM    184  CD1 PHE A  23       8.852   5.269 -14.906  1.00 98.41           C  \\nATOM    185  CD2 PHE A  23      10.265   5.873 -16.795  1.00 98.41           C  \\nATOM    186  CE1 PHE A  23       9.353   3.958 -14.946  1.00 98.41           C  \\nATOM    187  CE2 PHE A  23      10.782   4.568 -16.821  1.00 98.41           C  \\nATOM    188  CZ  PHE A  23      10.315   3.610 -15.905  1.00 98.41           C  \\nATOM    189  N   GLN A  24       6.742  10.029 -17.433  1.00 97.81           N  \\nATOM    190  CA  GLN A  24       6.075  11.305 -17.196  1.00 97.81           C  \\nATOM    191  C   GLN A  24       4.607  11.238 -17.615  1.00 97.81           C  \\nATOM    192  CB  GLN A  24       6.800  12.450 -17.915  1.00 97.81           C  \\nATOM    193  O   GLN A  24       4.276  11.236 -18.796  1.00 97.81           O  \\nATOM    194  CG  GLN A  24       8.225  12.661 -17.389  1.00 97.81           C  \\nATOM    195  CD  GLN A  24       8.949  13.804 -18.094  1.00 97.81           C  \\nATOM    196  NE2 GLN A  24      10.250  13.903 -17.927  1.00 97.81           N  \\nATOM    197  OE1 GLN A  24       8.385  14.634 -18.787  1.00 97.81           O  \\nATOM    198  N   LEU A  25       3.719  11.260 -16.624  1.00 97.99           N  \\nATOM    199  CA  LEU A  25       2.274  11.340 -16.833  1.00 97.99           C  \\nATOM    200  C   LEU A  25       1.817  12.801 -16.866  1.00 97.99           C  \\nATOM    201  CB  LEU A  25       1.557  10.545 -15.730  1.00 97.99           C  \\nATOM    202  O   LEU A  25       2.172  13.582 -15.976  1.00 97.99           O  \\nATOM    203  CG  LEU A  25       1.915   9.047 -15.707  1.00 97.99           C  \\nATOM    204  CD1 LEU A  25       1.310   8.402 -14.463  1.00 97.99           C  \\nATOM    205  CD2 LEU A  25       1.400   8.308 -16.942  1.00 97.99           C  \\nATOM    206  N   GLN A  26       1.007  13.160 -17.861  1.00 97.23           N  \\nATOM    207  CA  GLN A  26       0.364  14.472 -17.935  1.00 97.23           C  \\nATOM    208  C   GLN A  26      -0.884  14.515 -17.047  1.00 97.23           C  \\nATOM    209  CB  GLN A  26       0.018  14.820 -19.393  1.00 97.23           C  \\nATOM    210  O   GLN A  26      -1.458  13.488 -16.691  1.00 97.23           O  \\nATOM    211  CG  GLN A  26       1.233  14.789 -20.334  1.00 97.23           C  \\nATOM    212  CD  GLN A  26       2.348  15.730 -19.889  1.00 97.23           C  \\nATOM    213  NE2 GLN A  26       3.576  15.264 -19.824  1.00 97.23           N  \\nATOM    214  OE1 GLN A  26       2.130  16.894 -19.582  1.00 97.23           O  \\nATOM    215  N   GLU A  27      -1.367  15.714 -16.716  1.00 97.87           N  \\nATOM    216  CA  GLU A  27      -2.582  15.857 -15.900  1.00 97.87           C  \\nATOM    217  C   GLU A  27      -3.803  15.163 -16.533  1.00 97.87           C  \\nATOM    218  CB  GLU A  27      -2.862  17.348 -15.667  1.00 97.87           C  \\nATOM    219  O   GLU A  27      -4.608  14.557 -15.828  1.00 97.87           O  \\nATOM    220  CG  GLU A  27      -3.965  17.557 -14.622  1.00 97.87           C  \\nATOM    221  CD  GLU A  27      -4.282  19.041 -14.430  1.00 97.87           C  \\nATOM    222  OE1 GLU A  27      -5.455  19.410 -14.694  1.00 97.87           O  \\nATOM    223  OE2 GLU A  27      -3.356  19.780 -14.028  1.00 97.87           O  \\nATOM    224  N   GLU A  28      -3.923  15.188 -17.863  1.00 98.21           N  \\nATOM    225  CA  GLU A  28      -4.998  14.483 -18.570  1.00 98.21           C  \\nATOM    226  C   GLU A  28      -4.882  12.956 -18.468  1.00 98.21           C  \\nATOM    227  CB  GLU A  28      -5.060  14.935 -20.039  1.00 98.21           C  \\nATOM    228  O   GLU A  28      -5.907  12.277 -18.381  1.00 98.21           O  \\nATOM    229  CG  GLU A  28      -5.570  16.379 -20.201  1.00 98.21           C  \\nATOM    230  CD  GLU A  28      -6.943  16.611 -19.536  1.00 98.21           C  \\nATOM    231  OE1 GLU A  28      -7.112  17.646 -18.842  1.00 98.21           O  \\nATOM    232  OE2 GLU A  28      -7.826  15.725 -19.637  1.00 98.21           O  \\nATOM    233  N   ASP A  29      -3.665  12.410 -18.392  1.00 98.50           N  \\nATOM    234  CA  ASP A  29      -3.448  10.982 -18.139  1.00 98.50           C  \\nATOM    235  C   ASP A  29      -3.942  10.614 -16.738  1.00 98.50           C  \\nATOM    236  CB  ASP A  29      -1.964  10.623 -18.308  1.00 98.50           C  \\nATOM    237  O   ASP A  29      -4.709   9.666 -16.567  1.00 98.50           O  \\nATOM    238  CG  ASP A  29      -1.460  10.921 -19.721  1.00 98.50           C  \\nATOM    239  OD1 ASP A  29      -2.213  10.628 -20.684  1.00 98.50           O  \\nATOM    240  OD2 ASP A  29      -0.351  11.498 -19.804  1.00 98.50           O  \\nATOM    241  N   LEU A  30      -3.613  11.438 -15.741  1.00 98.74           N  \\nATOM    242  CA  LEU A  30      -4.077  11.241 -14.367  1.00 98.74           C  \\nATOM    243  C   LEU A  30      -5.600  11.355 -14.247  1.00 98.74           C  \\nATOM    244  CB  LEU A  30      -3.368  12.228 -13.427  1.00 98.74           C  \\nATOM    245  O   LEU A  30      -6.217  10.562 -13.538  1.00 98.74           O  \\nATOM    246  CG  LEU A  30      -1.833  12.144 -13.448  1.00 98.74           C  \\nATOM    247  CD1 LEU A  30      -1.252  13.129 -12.434  1.00 98.74           C  \\nATOM    248  CD2 LEU A  30      -1.317  10.739 -13.139  1.00 98.74           C  \\nATOM    249  N   LYS A  31      -6.238  12.269 -14.988  1.00 98.66           N  \\nATOM    250  CA  LYS A  31      -7.707  12.352 -15.057  1.00 98.66           C  \\nATOM    251  C   LYS A  31      -8.329  11.112 -15.701  1.00 98.66           C  \\nATOM    252  CB  LYS A  31      -8.140  13.608 -15.819  1.00 98.66           C  \\nATOM    253  O   LYS A  31      -9.411  10.706 -15.280  1.00 98.66           O  \\nATOM    254  CG  LYS A  31      -7.930  14.895 -15.012  1.00 98.66           C  \\nATOM    255  CD  LYS A  31      -8.233  16.108 -15.898  1.00 98.66           C  \\nATOM    256  CE  LYS A  31      -7.854  17.401 -15.178  1.00 98.66           C  \\nATOM    257  NZ  LYS A  31      -7.629  18.508 -16.136  1.00 98.66           N  \\nATOM    258  N   LYS A  32      -7.693  10.495 -16.705  1.00 98.62           N  \\nATOM    259  CA  LYS A  32      -8.167   9.215 -17.268  1.00 98.62           C  \\nATOM    260  C   LYS A  32      -8.091   8.099 -16.226  1.00 98.62           C  \\nATOM    261  CB  LYS A  32      -7.346   8.796 -18.490  1.00 98.62           C  \\nATOM    262  O   LYS A  32      -9.092   7.412 -16.031  1.00 98.62           O  \\nATOM    263  CG  LYS A  32      -7.537   9.617 -19.775  1.00 98.62           C  \\nATOM    264  CD  LYS A  32      -6.441   9.123 -20.728  1.00 98.62           C  \\nATOM    265  CE  LYS A  32      -6.374   9.750 -22.114  1.00 98.62           C  \\nATOM    266  NZ  LYS A  32      -5.176   9.188 -22.800  1.00 98.62           N  \\nATOM    267  N   VAL A  33      -6.949   7.954 -15.549  1.00 98.75           N  \\nATOM    268  CA  VAL A  33      -6.742   6.968 -14.470  1.00 98.75           C  \\nATOM    269  C   VAL A  33      -7.793   7.156 -13.373  1.00 98.75           C  \\nATOM    270  CB  VAL A  33      -5.309   7.083 -13.904  1.00 98.75           C  \\nATOM    271  O   VAL A  33      -8.487   6.207 -13.024  1.00 98.75           O  \\nATOM    272  CG1 VAL A  33      -5.048   6.190 -12.687  1.00 98.75           C  \\nATOM    273  CG2 VAL A  33      -4.269   6.678 -14.956  1.00 98.75           C  \\nATOM    274  N   MET A  34      -7.991   8.394 -12.913  1.00 98.59           N  \\nATOM    275  CA  MET A  34      -8.990   8.764 -11.907  1.00 98.59           C  \\nATOM    276  C   MET A  34     -10.418   8.364 -12.312  1.00 98.59           C  \\nATOM    277  CB  MET A  34      -8.888  10.279 -11.692  1.00 98.59           C  \\nATOM    278  O   MET A  34     -11.116   7.709 -11.542  1.00 98.59           O  \\nATOM    279  CG  MET A  34      -9.846  10.811 -10.629  1.00 98.59           C  \\nATOM    280  SD  MET A  34      -9.858  12.617 -10.534  1.00 98.59           S  \\nATOM    281  CE  MET A  34     -10.885  13.004 -11.976  1.00 98.59           C  \\nATOM    282  N   ARG A  35     -10.856   8.705 -13.533  1.00 98.46           N  \\nATOM    283  CA  ARG A  35     -12.208   8.361 -14.017  1.00 98.46           C  \\nATOM    284  C   ARG A  35     -12.406   6.852 -14.168  1.00 98.46           C  \\nATOM    285  CB  ARG A  35     -12.486   9.042 -15.362  1.00 98.46           C  \\nATOM    286  O   ARG A  35     -13.491   6.345 -13.897  1.00 98.46           O  \\nATOM    287  CG  ARG A  35     -12.665  10.564 -15.263  1.00 98.46           C  \\nATOM    288  CD  ARG A  35     -12.835  11.130 -16.681  1.00 98.46           C  \\nATOM    289  NE  ARG A  35     -12.507  12.569 -16.761  1.00 98.46           N  \\nATOM    290  NH1 ARG A  35     -11.067  12.494 -18.566  1.00 98.46           N  \\nATOM    291  NH2 ARG A  35     -11.467  14.434 -17.582  1.00 98.46           N  \\nATOM    292  CZ  ARG A  35     -11.692  13.152 -17.631  1.00 98.46           C  \\nATOM    293  N   ARG A  36     -11.376   6.126 -14.617  1.00 98.48           N  \\nATOM    294  CA  ARG A  36     -11.418   4.658 -14.715  1.00 98.48           C  \\nATOM    295  C   ARG A  36     -11.486   4.009 -13.337  1.00 98.48           C  \\nATOM    296  CB  ARG A  36     -10.213   4.133 -15.496  1.00 98.48           C  \\nATOM    297  O   ARG A  36     -12.287   3.100 -13.166  1.00 98.48           O  \\nATOM    298  CG  ARG A  36     -10.339   4.398 -16.994  1.00 98.48           C  \\nATOM    299  CD  ARG A  36      -9.145   3.772 -17.711  1.00 98.48           C  \\nATOM    300  NE  ARG A  36      -9.166   4.112 -19.139  1.00 98.48           N  \\nATOM    301  NH1 ARG A  36      -6.947   3.707 -19.570  1.00 98.48           N  \\nATOM    302  NH2 ARG A  36      -8.190   4.754 -21.070  1.00 98.48           N  \\nATOM    303  CZ  ARG A  36      -8.107   4.169 -19.915  1.00 98.48           C  \\nATOM    304  N   MET A  37     -10.737   4.529 -12.364  1.00 98.54           N  \\nATOM    305  CA  MET A  37     -10.836   4.106 -10.967  1.00 98.54           C  \\nATOM    306  C   MET A  37     -12.268   4.283 -10.446  1.00 98.54           C  \\nATOM    307  CB  MET A  37      -9.819   4.884 -10.114  1.00 98.54           C  \\nATOM    308  O   MET A  37     -12.851   3.321  -9.966  1.00 98.54           O  \\nATOM    309  CG  MET A  37      -9.827   4.452  -8.643  1.00 98.54           C  \\nATOM    310  SD  MET A  37      -9.274   2.755  -8.341  1.00 98.54           S  \\nATOM    311  CE  MET A  37      -7.488   2.936  -8.582  1.00 98.54           C  \\nATOM    312  N   GLN A  38     -12.880   5.464 -10.616  1.00 98.33           N  \\nATOM    313  CA  GLN A  38     -14.271   5.705 -10.189  1.00 98.33           C  \\nATOM    314  C   GLN A  38     -15.258   4.718 -10.827  1.00 98.33           C  \\nATOM    315  CB  GLN A  38     -14.700   7.139 -10.536  1.00 98.33           C  \\nATOM    316  O   GLN A  38     -16.119   4.178 -10.136  1.00 98.33           O  \\nATOM    317  CG  GLN A  38     -14.044   8.196  -9.640  1.00 98.33           C  \\nATOM    318  CD  GLN A  38     -14.454   9.607 -10.059  1.00 98.33           C  \\nATOM    319  NE2 GLN A  38     -15.281  10.282  -9.287  1.00 98.33           N  \\nATOM    320  OE1 GLN A  38     -14.039  10.098 -11.103  1.00 98.33           O  \\nATOM    321  N   LYS A  39     -15.099   4.435 -12.126  1.00 98.26           N  \\nATOM    322  CA  LYS A  39     -15.931   3.455 -12.832  1.00 98.26           C  \\nATOM    323  C   LYS A  39     -15.781   2.044 -12.251  1.00 98.26           C  \\nATOM    324  CB  LYS A  39     -15.588   3.488 -14.326  1.00 98.26           C  \\nATOM    325  O   LYS A  39     -16.784   1.358 -12.082  1.00 98.26           O  \\nATOM    326  CG  LYS A  39     -16.510   2.563 -15.129  1.00 98.26           C  \\nATOM    327  CD  LYS A  39     -16.054   2.460 -16.584  1.00 98.26           C  \\nATOM    328  CE  LYS A  39     -16.928   1.410 -17.273  1.00 98.26           C  \\nATOM    329  NZ  LYS A  39     -16.346   0.981 -18.564  1.00 98.26           N  \\nATOM    330  N   GLU A  40     -14.561   1.602 -11.957  1.00 98.47           N  \\nATOM    331  CA  GLU A  40     -14.345   0.280 -11.356  1.00 98.47           C  \\nATOM    332  C   GLU A  40     -14.818   0.221  -9.900  1.00 98.47           C  \\nATOM    333  CB  GLU A  40     -12.879  -0.159 -11.496  1.00 98.47           C  \\nATOM    334  O   GLU A  40     -15.348  -0.803  -9.485  1.00 98.47           O  \\nATOM    335  CG  GLU A  40     -12.487  -0.500 -12.944  1.00 98.47           C  \\nATOM    336  CD  GLU A  40     -13.431  -1.540 -13.573  1.00 98.47           C  \\nATOM    337  OE1 GLU A  40     -14.058  -1.223 -14.620  1.00 98.47           O  \\nATOM    338  OE2 GLU A  40     -13.704  -2.589 -12.945  1.00 98.47           O  \\nATOM    339  N   MET A  41     -14.747   1.325  -9.150  1.00 98.52           N  \\nATOM    340  CA  MET A  41     -15.372   1.426  -7.826  1.00 98.52           C  \\nATOM    341  C   MET A  41     -16.901   1.289  -7.907  1.00 98.52           C  \\nATOM    342  CB  MET A  41     -15.023   2.765  -7.165  1.00 98.52           C  \\nATOM    343  O   MET A  41     -17.491   0.554  -7.120  1.00 98.52           O  \\nATOM    344  CG  MET A  41     -13.541   2.937  -6.815  1.00 98.52           C  \\nATOM    345  SD  MET A  41     -13.135   4.622  -6.272  1.00 98.52           S  \\nATOM    346  CE  MET A  41     -13.899   4.565  -4.629  1.00 98.52           C  \\nATOM    347  N   ASP A  42     -17.551   1.949  -8.874  1.00 97.88           N  \\nATOM    348  CA  ASP A  42     -18.991   1.778  -9.120  1.00 97.88           C  \\nATOM    349  C   ASP A  42     -19.338   0.327  -9.445  1.00 97.88           C  \\nATOM    350  CB  ASP A  42     -19.461   2.650 -10.299  1.00 97.88           C  \\nATOM    351  O   ASP A  42     -20.325  -0.204  -8.938  1.00 97.88           O  \\nATOM    352  CG  ASP A  42     -19.789   4.081  -9.908  1.00 97.88           C  \\nATOM    353  OD1 ASP A  42     -20.393   4.257  -8.825  1.00 97.88           O  \\nATOM    354  OD2 ASP A  42     -19.489   4.993 -10.704  1.00 97.88           O  \\nATOM    355  N   ARG A  43     -18.524  -0.329 -10.281  1.00 98.22           N  \\nATOM    356  CA  ARG A  43     -18.731  -1.739 -10.617  1.00 98.22           C  \\nATOM    357  C   ARG A  43     -18.532  -2.648  -9.408  1.00 98.22           C  \\nATOM    358  CB  ARG A  43     -17.810  -2.179 -11.759  1.00 98.22           C  \\nATOM    359  O   ARG A  43     -19.302  -3.589  -9.242  1.00 98.22           O  \\nATOM    360  CG  ARG A  43     -18.212  -1.578 -13.109  1.00 98.22           C  \\nATOM    361  CD  ARG A  43     -17.203  -2.002 -14.180  1.00 98.22           C  \\nATOM    362  NE  ARG A  43     -17.327  -3.429 -14.549  1.00 98.22           N  \\nATOM    363  NH1 ARG A  43     -15.137  -3.775 -15.187  1.00 98.22           N  \\nATOM    364  NH2 ARG A  43     -16.578  -5.461 -15.274  1.00 98.22           N  \\nATOM    365  CZ  ARG A  43     -16.350  -4.207 -14.993  1.00 98.22           C  \\nATOM    366  N   GLY A  44     -17.534  -2.360  -8.576  1.00 97.95           N  \\nATOM    367  CA  GLY A  44     -17.220  -3.124  -7.373  1.00 97.95           C  \\nATOM    368  C   GLY A  44     -18.308  -3.056  -6.309  1.00 97.95           C  \\nATOM    369  O   GLY A  44     -18.507  -4.024  -5.587  1.00 97.95           O  \\nATOM    370  N   LEU A  45     -19.032  -1.943  -6.218  1.00 97.67           N  \\nATOM    371  CA  LEU A  45     -20.094  -1.757  -5.226  1.00 97.67           C  \\nATOM    372  C   LEU A  45     -21.442  -2.378  -5.617  1.00 97.67           C  \\nATOM    373  CB  LEU A  45     -20.238  -0.252  -4.981  1.00 97.67           C  \\nATOM    374  O   LEU A  45     -22.279  -2.606  -4.743  1.00 97.67           O  \\nATOM    375  CG  LEU A  45     -19.154   0.318  -4.056  1.00 97.67           C  \\nATOM    376  CD1 LEU A  45     -19.211   1.836  -4.100  1.00 97.67           C  \\nATOM    377  CD2 LEU A  45     -19.334  -0.116  -2.603  1.00 97.67           C  \\nATOM    378  N   ARG A  46     -21.659  -2.647  -6.909  1.00 97.47           N  \\nATOM    379  CA  ARG A  46     -22.913  -3.205  -7.432  1.00 97.47           C  \\nATOM    380  C   ARG A  46     -22.898  -4.721  -7.450  1.00 97.47           C  \\nATOM    381  CB  ARG A  46     -23.181  -2.692  -8.842  1.00 97.47           C  \\nATOM    382  O   ARG A  46     -21.939  -5.324  -7.931  1.00 97.47           O  \\nATOM    383  CG  ARG A  46     -23.542  -1.211  -8.853  1.00 97.47           C  \\nATOM    384  CD  ARG A  46     -23.707  -0.786 -10.308  1.00 97.47           C  \\nATOM    385  NE  ARG A  46     -23.852   0.671 -10.405  1.00 97.47           N  \\nATOM    386  NH1 ARG A  46     -24.542   0.732 -12.582  1.00 97.47           N  \\nATOM    387  NH2 ARG A  46     -24.261   2.643 -11.441  1.00 97.47           N  \\nATOM    388  CZ  ARG A  46     -24.219   1.341 -11.473  1.00 97.47           C  \\nATOM    389  N   LEU A  47     -24.004  -5.335  -7.041  1.00 95.11           N  \\nATOM    390  CA  LEU A  47     -24.113  -6.792  -6.948  1.00 95.11           C  \\nATOM    391  C   LEU A  47     -23.919  -7.473  -8.314  1.00 95.11           C  \\nATOM    392  CB  LEU A  47     -25.477  -7.133  -6.323  1.00 95.11           C  \\nATOM    393  O   LEU A  47     -23.271  -8.511  -8.398  1.00 95.11           O  \\nATOM    394  CG  LEU A  47     -25.678  -8.632  -6.030  1.00 95.11           C  \\nATOM    395  CD1 LEU A  47     -24.730  -9.136  -4.939  1.00 95.11           C  \\nATOM    396  CD2 LEU A  47     -27.114  -8.878  -5.568  1.00 95.11           C  \\nATOM    397  N   GLU A  48     -24.441  -6.867  -9.384  1.00 97.04           N  \\nATOM    398  CA  GLU A  48     -24.373  -7.405 -10.752  1.00 97.04           C  \\nATOM    399  C   GLU A  48     -22.946  -7.429 -11.321  1.00 97.04           C  \\nATOM    400  CB  GLU A  48     -25.305  -6.569 -11.650  1.00 97.04           C  \\nATOM    401  O   GLU A  48     -22.599  -8.331 -12.077  1.00 97.04           O  \\nATOM    402  CG  GLU A  48     -25.420  -7.100 -13.092  1.00 97.04           C  \\nATOM    403  CD  GLU A  48     -26.362  -6.275 -13.990  1.00 97.04           C  \\nATOM    404  OE1 GLU A  48     -26.570  -6.693 -15.153  1.00 97.04           O  \\nATOM    405  OE2 GLU A  48     -26.867  -5.220 -13.540  1.00 97.04           O  \\nATOM    406  N   THR A  49     -22.109  -6.448 -10.972  1.00 97.71           N  \\nATOM    407  CA  THR A  49     -20.794  -6.249 -11.607  1.00 97.71           C  \\nATOM    408  C   THR A  49     -19.604  -6.516 -10.687  1.00 97.71           C  \\nATOM    409  CB  THR A  49     -20.689  -4.852 -12.230  1.00 97.71           C  \\nATOM    410  O   THR A  49     -18.470  -6.523 -11.163  1.00 97.71           O  \\nATOM    411  CG2 THR A  49     -21.639  -4.666 -13.412  1.00 97.71           C  \\nATOM    412  OG1 THR A  49     -21.030  -3.848 -11.310  1.00 97.71           O  \\nATOM    413  N   HIS A  50     -19.834  -6.760  -9.395  1.00 96.77           N  \\nATOM    414  CA  HIS A  50     -18.790  -6.948  -8.383  1.00 96.77           C  \\nATOM    415  C   HIS A  50     -17.804  -8.080  -8.711  1.00 96.77           C  \\nATOM    416  CB  HIS A  50     -19.489  -7.231  -7.048  1.00 96.77           C  \\nATOM    417  O   HIS A  50     -16.589  -7.945  -8.523  1.00 96.77           O  \\nATOM    418  CG  HIS A  50     -18.541  -7.581  -5.935  1.00 96.77           C  \\nATOM    419  CD2 HIS A  50     -18.244  -8.828  -5.458  1.00 96.77           C  \\nATOM    420  ND1 HIS A  50     -17.826  -6.686  -5.187  1.00 96.77           N  \\nATOM    421  CE1 HIS A  50     -17.138  -7.368  -4.265  1.00 96.77           C  \\nATOM    422  NE2 HIS A  50     -17.340  -8.688  -4.398  1.00 96.77           N  \\nATOM    423  N   GLU A  51     -18.307  -9.207  -9.223  1.00 94.57           N  \\nATOM    424  CA  GLU A  51     -17.473 -10.370  -9.552  1.00 94.57           C  \\nATOM    425  C   GLU A  51     -16.443 -10.045 -10.647  1.00 94.57           C  \\nATOM    426  CB  GLU A  51     -18.371 -11.554  -9.946  1.00 94.57           C  \\nATOM    427  O   GLU A  51     -15.287 -10.459 -10.548  1.00 94.57           O  \\nATOM    428  CG  GLU A  51     -17.556 -12.851 -10.095  1.00 94.57           C  \\nATOM    429  CD  GLU A  51     -18.408 -14.102 -10.372  1.00 94.57           C  \\nATOM    430  OE1 GLU A  51     -17.795 -15.188 -10.498  1.00 94.57           O  \\nATOM    431  OE2 GLU A  51     -19.653 -13.991 -10.425  1.00 94.57           O  \\nATOM    432  N   GLU A  52     -16.818  -9.218 -11.623  1.00 95.46           N  \\nATOM    433  CA  GLU A  52     -15.971  -8.824 -12.755  1.00 95.46           C  \\nATOM    434  C   GLU A  52     -15.170  -7.536 -12.519  1.00 95.46           C  \\nATOM    435  CB  GLU A  52     -16.848  -8.600 -13.988  1.00 95.46           C  \\nATOM    436  O   GLU A  52     -14.249  -7.243 -13.279  1.00 95.46           O  \\nATOM    437  CG  GLU A  52     -17.655  -9.819 -14.453  1.00 95.46           C  \\nATOM    438  CD  GLU A  52     -18.460  -9.496 -15.724  1.00 95.46           C  \\nATOM    439  OE1 GLU A  52     -18.987 -10.453 -16.335  1.00 95.46           O  \\nATOM    440  OE2 GLU A  52     -18.514  -8.296 -16.104  1.00 95.46           O  \\nATOM    441  N   ALA A  53     -15.531  -6.733 -11.515  1.00 97.22           N  \\nATOM    442  CA  ALA A  53     -14.846  -5.479 -11.217  1.00 97.22           C  \\nATOM    443  C   ALA A  53     -13.401  -5.738 -10.774  1.00 97.22           C  \\nATOM    444  CB  ALA A  53     -15.625  -4.731 -10.133  1.00 97.22           C  \\nATOM    445  O   ALA A  53     -13.153  -6.631  -9.953  1.00 97.22           O  \\nATOM    446  N   SER A  54     -12.449  -4.941 -11.263  1.00 96.53           N  \\nATOM    447  CA  SER A  54     -11.054  -5.056 -10.819  1.00 96.53           C  \\nATOM    448  C   SER A  54     -10.874  -4.500  -9.400  1.00 96.53           C  \\nATOM    449  CB  SER A  54     -10.129  -4.356 -11.821  1.00 96.53           C  \\nATOM    450  O   SER A  54     -10.081  -5.009  -8.616  1.00 96.53           O  \\nATOM    451  OG  SER A  54     -10.189  -2.952 -11.659  1.00 96.53           O  \\nATOM    452  N   VAL A  55     -11.630  -3.453  -9.055  1.00 97.96           N  \\nATOM    453  CA  VAL A  55     -11.655  -2.837  -7.722  1.00 97.96           C  \\nATOM    454  C   VAL A  55     -12.819  -3.444  -6.946  1.00 97.96           C  \\nATOM    455  CB  VAL A  55     -11.779  -1.305  -7.827  1.00 97.96           C  \\nATOM    456  O   VAL A  55     -13.976  -3.197  -7.273  1.00 97.96           O  \\nATOM    457  CG1 VAL A  55     -11.705  -0.649  -6.447  1.00 97.96           C  \\nATOM    458  CG2 VAL A  55     -10.646  -0.705  -8.668  1.00 97.96           C  \\nATOM    459  N   LYS A  56     -12.530  -4.278  -5.941  1.00 96.50           N  \\nATOM    460  CA  LYS A  56     -13.550  -5.134  -5.313  1.00 96.50           C  \\nATOM    461  C   LYS A  56     -14.473  -4.424  -4.333  1.00 96.50           C  \\nATOM    462  CB  LYS A  56     -12.904  -6.376  -4.671  1.00 96.50           C  \\nATOM    463  O   LYS A  56     -15.584  -4.899  -4.154  1.00 96.50           O  \\nATOM    464  CG  LYS A  56     -12.315  -7.385  -5.673  1.00 96.50           C  \\nATOM    465  CD  LYS A  56     -13.367  -7.817  -6.703  1.00 96.50           C  \\nATOM    466  CE  LYS A  56     -12.935  -8.980  -7.592  1.00 96.50           C  \\nATOM    467  NZ  LYS A  56     -13.856  -9.035  -8.747  1.00 96.50           N  \\nATOM    468  N   MET A  57     -14.066  -3.310  -3.723  1.00 97.70           N  \\nATOM    469  CA  MET A  57     -14.947  -2.531  -2.834  1.00 97.70           C  \\nATOM    470  C   MET A  57     -15.571  -3.386  -1.714  1.00 97.70           C  \\nATOM    471  CB  MET A  57     -16.010  -1.790  -3.662  1.00 97.70           C  \\nATOM    472  O   MET A  57     -16.782  -3.403  -1.502  1.00 97.70           O  \\nATOM    473  CG  MET A  57     -15.395  -0.943  -4.777  1.00 97.70           C  \\nATOM    474  SD  MET A  57     -14.324   0.396  -4.201  1.00 97.70           S  \\nATOM    475  CE  MET A  57     -15.610   1.486  -3.570  1.00 97.70           C  \\nATOM    476  N   LEU A  58     -14.726  -4.130  -1.004  1.00 97.01           N  \\nATOM    477  CA  LEU A  58     -15.116  -5.101   0.011  1.00 97.01           C  \\nATOM    478  C   LEU A  58     -15.724  -4.408   1.251  1.00 97.01           C  \\nATOM    479  CB  LEU A  58     -13.899  -5.967   0.387  1.00 97.01           C  \\nATOM    480  O   LEU A  58     -15.044  -3.600   1.897  1.00 97.01           O  \\nATOM    481  CG  LEU A  58     -13.298  -6.764  -0.787  1.00 97.01           C  \\nATOM    482  CD1 LEU A  58     -12.066  -7.538  -0.324  1.00 97.01           C  \\nATOM    483  CD2 LEU A  58     -14.282  -7.783  -1.368  1.00 97.01           C  \\nATOM    484  N   PRO A  59     -16.971  -4.741   1.637  1.00 95.88           N  \\nATOM    485  CA  PRO A  59     -17.580  -4.255   2.871  1.00 95.88           C  \\nATOM    486  C   PRO A  59     -16.829  -4.772   4.102  1.00 95.88           C  \\nATOM    487  CB  PRO A  59     -19.030  -4.756   2.850  1.00 95.88           C  \\nATOM    488  O   PRO A  59     -16.488  -5.951   4.181  1.00 95.88           O  \\nATOM    489  CG  PRO A  59     -19.295  -5.096   1.388  1.00 95.88           C  \\nATOM    490  CD  PRO A  59     -17.930  -5.538   0.889  1.00 95.88           C  \\nATOM    491  N   THR A  60     -16.590  -3.901   5.083  1.00 94.13           N  \\nATOM    492  CA  THR A  60     -15.776  -4.238   6.271  1.00 94.13           C  \\nATOM    493  C   THR A  60     -16.601  -4.481   7.534  1.00 94.13           C  \\nATOM    494  CB  THR A  60     -14.750  -3.138   6.570  1.00 94.13           C  \\nATOM    495  O   THR A  60     -16.049  -4.866   8.559  1.00 94.13           O  \\nATOM    496  CG2 THR A  60     -13.894  -2.757   5.358  1.00 94.13           C  \\nATOM    497  OG1 THR A  60     -15.425  -1.990   7.022  1.00 94.13           O  \\nATOM    498  N   TYR A  61     -17.911  -4.207   7.490  1.00 91.04           N  \\nATOM    499  CA  TYR A  61     -18.823  -4.220   8.645  1.00 91.04           C  \\nATOM    500  C   TYR A  61     -18.483  -3.207   9.758  1.00 91.04           C  \\nATOM    501  CB  TYR A  61     -19.043  -5.656   9.153  1.00 91.04           C  \\nATOM    502  O   TYR A  61     -19.196  -3.114  10.759  1.00 91.04           O  \\nATOM    503  CG  TYR A  61     -19.774  -6.539   8.160  1.00 91.04           C  \\nATOM    504  CD1 TYR A  61     -21.134  -6.842   8.361  1.00 91.04           C  \\nATOM    505  CD2 TYR A  61     -19.104  -7.046   7.030  1.00 91.04           C  \\nATOM    506  CE1 TYR A  61     -21.821  -7.648   7.434  1.00 91.04           C  \\nATOM    507  CE2 TYR A  61     -19.789  -7.843   6.096  1.00 91.04           C  \\nATOM    508  OH  TYR A  61     -21.814  -8.925   5.407  1.00 91.04           O  \\nATOM    509  CZ  TYR A  61     -21.149  -8.153   6.303  1.00 91.04           C  \\nATOM    510  N   VAL A  62     -17.481  -2.344   9.558  1.00 91.59           N  \\nATOM    511  CA  VAL A  62     -17.222  -1.187  10.424  1.00 91.59           C  \\nATOM    512  C   VAL A  62     -18.175  -0.053  10.032  1.00 91.59           C  \\nATOM    513  CB  VAL A  62     -15.738  -0.771  10.376  1.00 91.59           C  \\nATOM    514  O   VAL A  62     -17.945   0.675   9.069  1.00 91.59           O  \\nATOM    515  CG1 VAL A  62     -15.459   0.405  11.322  1.00 91.59           C  \\nATOM    516  CG2 VAL A  62     -14.833  -1.935  10.802  1.00 91.59           C  \\nATOM    517  N   ARG A  63     -19.286   0.073  10.770  1.00 87.26           N  \\nATOM    518  CA  ARG A  63     -20.339   1.089  10.536  1.00 87.26           C  \\nATOM    519  C   ARG A  63     -20.217   2.362  11.379  1.00 87.26           C  \\nATOM    520  CB  ARG A  63     -21.736   0.472  10.719  1.00 87.26           C  \\nATOM    521  O   ARG A  63     -20.993   3.294  11.211  1.00 87.26           O  \\nATOM    522  CG  ARG A  63     -22.088  -0.584   9.661  1.00 87.26           C  \\nATOM    523  CD  ARG A  63     -23.600  -0.862   9.701  1.00 87.26           C  \\nATOM    524  NE  ARG A  63     -24.023  -1.873   8.709  1.00 87.26           N  \\nATOM    525  NH1 ARG A  63     -26.202  -1.170   8.417  1.00 87.26           N  \\nATOM    526  NH2 ARG A  63     -25.471  -2.943   7.295  1.00 87.26           N  \\nATOM    527  CZ  ARG A  63     -25.223  -1.987   8.150  1.00 87.26           C  \\nATOM    528  N   SER A  64     -19.302   2.396  12.341  1.00 76.94           N  \\nATOM    529  CA  SER A  64     -19.133   3.550  13.224  1.00 76.94           C  \\nATOM    530  C   SER A  64     -17.683   3.716  13.624  1.00 76.94           C  \\nATOM    531  CB  SER A  64     -20.005   3.435  14.479  1.00 76.94           C  \\nATOM    532  O   SER A  64     -16.933   2.746  13.721  1.00 76.94           O  \\nATOM    533  OG  SER A  64     -19.666   2.271  15.213  1.00 76.94           O  \\nATOM    534  N   THR A  65     -17.331   4.955  13.904  1.00 77.74           N  \\nATOM    535  CA  THR A  65     -16.035   5.368  14.414  1.00 77.74           C  \\nATOM    536  C   THR A  65     -16.079   5.503  15.945  1.00 77.74           C  \\nATOM    537  CB  THR A  65     -15.667   6.687  13.740  1.00 77.74           C  \\nATOM    538  O   THR A  65     -17.174   5.533  16.515  1.00 77.74           O  \\nATOM    539  CG2 THR A  65     -15.401   6.501  12.244  1.00 77.74           C  \\nATOM    540  OG1 THR A  65     -16.749   7.586  13.853  1.00 77.74           O  \\nATOM    541  N   PRO A  66     -14.924   5.525  16.637  1.00 79.65           N  \\nATOM    542  CA  PRO A  66     -14.876   5.750  18.081  1.00 79.65           C  \\nATOM    543  C   PRO A  66     -15.467   7.112  18.462  1.00 79.65           C  \\nATOM    544  CB  PRO A  66     -13.398   5.646  18.475  1.00 79.65           C  \\nATOM    545  O   PRO A  66     -15.230   8.100  17.771  1.00 79.65           O  \\nATOM    546  CG  PRO A  66     -12.774   4.842  17.337  1.00 79.65           C  \\nATOM    547  CD  PRO A  66     -13.591   5.269  16.122  1.00 79.65           C  \\nATOM    548  N   GLU A  67     -16.199   7.167  19.575  1.00 79.31           N  \\nATOM    549  CA  GLU A  67     -16.833   8.391  20.097  1.00 79.31           C  \\nATOM    550  C   GLU A  67     -16.007   9.057  21.213  1.00 79.31           C  \\nATOM    551  CB  GLU A  67     -18.242   8.056  20.616  1.00 79.31           C  \\nATOM    552  O   GLU A  67     -16.404  10.090  21.749  1.00 79.31           O  \\nATOM    553  CG  GLU A  67     -19.219   7.584  19.525  1.00 79.31           C  \\nATOM    554  CD  GLU A  67     -20.558   7.084  20.099  1.00 79.31           C  \\nATOM    555  OE1 GLU A  67     -21.512   6.938  19.303  1.00 79.31           O  \\nATOM    556  OE2 GLU A  67     -20.624   6.761  21.318  1.00 79.31           O  \\nATOM    557  N   GLY A  68     -14.886   8.448  21.618  1.00 76.31           N  \\nATOM    558  CA  GLY A  68     -14.038   8.944  22.706  1.00 76.31           C  \\nATOM    559  C   GLY A  68     -14.556   8.575  24.098  1.00 76.31           C  \\nATOM    560  O   GLY A  68     -14.277   9.278  25.062  1.00 76.31           O  \\nATOM    561  N   SER A  69     -15.331   7.492  24.205  1.00 77.45           N  \\nATOM    562  CA  SER A  69     -15.860   6.959  25.477  1.00 77.45           C  \\nATOM    563  C   SER A  69     -15.552   5.466  25.691  1.00 77.45           C  \\nATOM    564  CB  SER A  69     -17.353   7.265  25.621  1.00 77.45           C  \\nATOM    565  O   SER A  69     -15.996   4.858  26.665  1.00 77.45           O  \\nATOM    566  OG  SER A  69     -18.058   6.876  24.459  1.00 77.45           O  \\nATOM    567  N   GLU A  70     -14.769   4.855  24.802  1.00 81.98           N  \\nATOM    568  CA  GLU A  70     -14.397   3.437  24.791  1.00 81.98           C  \\nATOM    569  C   GLU A  70     -13.254   3.054  25.764  1.00 81.98           C  \\nATOM    570  CB  GLU A  70     -13.967   3.063  23.360  1.00 81.98           C  \\nATOM    571  O   GLU A  70     -12.089   3.049  25.379  1.00 81.98           O  \\nATOM    572  CG  GLU A  70     -15.023   3.168  22.256  1.00 81.98           C  \\nATOM    573  CD  GLU A  70     -15.331   4.593  21.777  1.00 81.98           C  \\nATOM    574  OE1 GLU A  70     -16.377   4.747  21.115  1.00 81.98           O  \\nATOM    575  OE2 GLU A  70     -14.595   5.552  22.108  1.00 81.98           O  \\nATOM    576  N   VAL A  71     -13.518   2.735  27.032  1.00 83.64           N  \\nATOM    577  CA  VAL A  71     -12.443   2.400  27.997  1.00 83.64           C  \\nATOM    578  C   VAL A  71     -12.064   0.913  27.945  1.00 83.64           C  \\nATOM    579  CB  VAL A  71     -12.817   2.795  29.439  1.00 83.64           C  \\nATOM    580  O   VAL A  71     -12.943   0.053  27.919  1.00 83.64           O  \\nATOM    581  CG1 VAL A  71     -11.619   2.687  30.393  1.00 83.64           C  \\nATOM    582  CG2 VAL A  71     -13.319   4.234  29.549  1.00 83.64           C  \\nATOM    583  N   GLY A  72     -10.770   0.584  28.022  1.00 88.91           N  \\nATOM    584  CA  GLY A  72     -10.309  -0.789  28.249  1.00 88.91           C  \\nATOM    585  C   GLY A  72      -8.846  -1.065  27.890  1.00 88.91           C  \\nATOM    586  O   GLY A  72      -8.173  -0.271  27.234  1.00 88.91           O  \\nATOM    587  N   ASP A  73      -8.368  -2.236  28.315  1.00 92.05           N  \\nATOM    588  CA  ASP A  73      -7.118  -2.832  27.840  1.00 92.05           C  \\nATOM    589  C   ASP A  73      -7.459  -3.810  26.700  1.00 92.05           C  \\nATOM    590  CB  ASP A  73      -6.383  -3.571  28.983  1.00 92.05           C  \\nATOM    591  O   ASP A  73      -8.223  -4.757  26.895  1.00 92.05           O  \\nATOM    592  CG  ASP A  73      -5.624  -2.716  30.018  1.00 92.05           C  \\nATOM    593  OD1 ASP A  73      -5.597  -1.472  29.961  1.00 92.05           O  \\nATOM    594  OD2 ASP A  73      -4.913  -3.303  30.879  1.00 92.05           O  \\nATOM    595  N   PHE A  74      -6.861  -3.608  25.531  1.00 93.99           N  \\nATOM    596  CA  PHE A  74      -7.079  -4.404  24.326  1.00 93.99           C  \\nATOM    597  C   PHE A  74      -5.754  -4.954  23.833  1.00 93.99           C  \\nATOM    598  CB  PHE A  74      -7.728  -3.539  23.239  1.00 93.99           C  \\nATOM    599  O   PHE A  74      -4.723  -4.282  23.914  1.00 93.99           O  \\nATOM    600  CG  PHE A  74      -9.064  -2.971  23.657  1.00 93.99           C  \\nATOM    601  CD1 PHE A  74     -10.238  -3.707  23.430  1.00 93.99           C  \\nATOM    602  CD2 PHE A  74      -9.127  -1.737  24.331  1.00 93.99           C  \\nATOM    603  CE1 PHE A  74     -11.470  -3.238  23.917  1.00 93.99           C  \\nATOM    604  CE2 PHE A  74     -10.361  -1.257  24.799  1.00 93.99           C  \\nATOM    605  CZ  PHE A  74     -11.527  -2.018  24.615  1.00 93.99           C  \\nATOM    606  N   LEU A  75      -5.773  -6.161  23.283  1.00 95.28           N  \\nATOM    607  CA  LEU A  75      -4.649  -6.628  22.492  1.00 95.28           C  \\nATOM    608  C   LEU A  75      -4.947  -6.369  21.013  1.00 95.28           C  \\nATOM    609  CB  LEU A  75      -4.331  -8.085  22.851  1.00 95.28           C  \\nATOM    610  O   LEU A  75      -6.089  -6.499  20.572  1.00 95.28           O  \\nATOM    611  CG  LEU A  75      -2.882  -8.445  22.470  1.00 95.28           C  \\nATOM    612  CD1 LEU A  75      -1.900  -8.001  23.553  1.00 95.28           C  \\nATOM    613  CD2 LEU A  75      -2.681  -9.938  22.360  1.00 95.28           C  \\nATOM    614  N   SER A  76      -3.931  -6.012  20.237  1.00 95.61           N  \\nATOM    615  CA  SER A  76      -4.033  -5.981  18.787  1.00 95.61           C  \\nATOM    616  C   SER A  76      -2.896  -6.725  18.111  1.00 95.61           C  \\nATOM    617  CB  SER A  76      -4.230  -4.574  18.231  1.00 95.61           C  \\nATOM    618  O   SER A  76      -1.756  -6.741  18.581  1.00 95.61           O  \\nATOM    619  OG  SER A  76      -3.089  -3.765  18.374  1.00 95.61           O  \\nATOM    620  N   LEU A  77      -3.244  -7.384  17.014  1.00 96.38           N  \\nATOM    621  CA  LEU A  77      -2.316  -8.068  16.129  1.00 96.38           C  \\nATOM    622  C   LEU A  77      -2.283  -7.327  14.804  1.00 96.38           C  \\nATOM    623  CB  LEU A  77      -2.747  -9.521  15.897  1.00 96.38           C  \\nATOM    624  O   LEU A  77      -3.315  -6.857  14.337  1.00 96.38           O  \\nATOM    625  CG  LEU A  77      -3.104 -10.321  17.144  1.00 96.38           C  \\nATOM    626  CD1 LEU A  77      -3.460 -11.745  16.730  1.00 96.38           C  \\nATOM    627  CD2 LEU A  77      -1.993 -10.351  18.196  1.00 96.38           C  \\nATOM    628  N   ASP A  78      -1.118  -7.268  14.185  1.00 95.07           N  \\nATOM    629  CA  ASP A  78      -0.927  -6.636  12.888  1.00 95.07           C  \\nATOM    630  C   ASP A  78      -0.044  -7.537  12.030  1.00 95.07           C  \\nATOM    631  CB  ASP A  78      -0.362  -5.237  13.139  1.00 95.07           C  \\nATOM    632  O   ASP A  78       1.164  -7.654  12.260  1.00 95.07           O  \\nATOM    633  CG  ASP A  78       0.032  -4.477  11.881  1.00 95.07           C  \\nATOM    634  OD1 ASP A  78      -0.519  -4.754  10.800  1.00 95.07           O  \\nATOM    635  OD2 ASP A  78       0.832  -3.522  12.050  1.00 95.07           O  \\nATOM    636  N   LEU A  79      -0.681  -8.242  11.093  1.00 93.13           N  \\nATOM    637  CA  LEU A  79      -0.012  -9.096  10.120  1.00 93.13           C  \\nATOM    638  C   LEU A  79       0.145  -8.339   8.800  1.00 93.13           C  \\nATOM    639  CB  LEU A  79      -0.771 -10.425   9.972  1.00 93.13           C  \\nATOM    640  O   LEU A  79      -0.722  -8.394   7.924  1.00 93.13           O  \\nATOM    641  CG  LEU A  79      -0.013 -11.436   9.091  1.00 93.13           C  \\nATOM    642  CD1 LEU A  79       1.190 -12.021   9.827  1.00 93.13           C  \\nATOM    643  CD2 LEU A  79      -0.933 -12.586   8.706  1.00 93.13           C  \\nATOM    644  N   GLY A  80       1.280  -7.652   8.675  1.00 85.19           N  \\nATOM    645  CA  GLY A  80       1.659  -6.927   7.470  1.00 85.19           C  \\nATOM    646  C   GLY A  80       2.419  -7.789   6.457  1.00 85.19           C  \\nATOM    647  O   GLY A  80       2.668  -8.977   6.645  1.00 85.19           O  \\nATOM    648  N   GLY A  81       2.875  -7.157   5.372  1.00 75.33           N  \\nATOM    649  CA  GLY A  81       3.600  -7.838   4.290  1.00 75.33           C  \\nATOM    650  C   GLY A  81       5.038  -8.277   4.616  1.00 75.33           C  \\nATOM    651  O   GLY A  81       5.711  -8.816   3.743  1.00 75.33           O  \\nATOM    652  N   THR A  82       5.557  -7.988   5.813  1.00 73.91           N  \\nATOM    653  CA  THR A  82       6.976  -8.230   6.165  1.00 73.91           C  \\nATOM    654  C   THR A  82       7.170  -8.543   7.645  1.00 73.91           C  \\nATOM    655  CB  THR A  82       7.843  -7.008   5.798  1.00 73.91           C  \\nATOM    656  O   THR A  82       7.963  -9.412   7.993  1.00 73.91           O  \\nATOM    657  CG2 THR A  82       9.343  -7.261   5.950  1.00 73.91           C  \\nATOM    658  OG1 THR A  82       7.611  -6.630   4.456  1.00 73.91           O  \\nATOM    659  N   ASN A  83       6.440  -7.854   8.522  1.00 86.23           N  \\nATOM    660  CA  ASN A  83       6.534  -8.038   9.964  1.00 86.23           C  \\nATOM    661  C   ASN A  83       5.169  -8.405  10.533  1.00 86.23           C  \\nATOM    662  CB  ASN A  83       7.091  -6.765  10.620  1.00 86.23           C  \\nATOM    663  O   ASN A  83       4.136  -7.944  10.043  1.00 86.23           O  \\nATOM    664  CG  ASN A  83       8.489  -6.420  10.141  1.00 86.23           C  \\nATOM    665  ND2 ASN A  83       8.726  -5.183   9.773  1.00 86.23           N  \\nATOM    666  OD1 ASN A  83       9.390  -7.238  10.093  1.00 86.23           O  \\nATOM    667  N   PHE A  84       5.202  -9.186  11.602  1.00 93.95           N  \\nATOM    668  CA  PHE A  84       4.079  -9.391  12.493  1.00 93.95           C  \\nATOM    669  C   PHE A  84       4.289  -8.557  13.754  1.00 93.95           C  \\nATOM    670  CB  PHE A  84       3.947 -10.882  12.805  1.00 93.95           C  \\nATOM    671  O   PHE A  84       5.397  -8.501  14.291  1.00 93.95           O  \\nATOM    672  CG  PHE A  84       2.811 -11.175  13.754  1.00 93.95           C  \\nATOM    673  CD1 PHE A  84       3.058 -11.722  15.026  1.00 93.95           C  \\nATOM    674  CD2 PHE A  84       1.497 -10.868  13.362  1.00 93.95           C  \\nATOM    675  CE1 PHE A  84       1.982 -11.957  15.899  1.00 93.95           C  \\nATOM    676  CE2 PHE A  84       0.427 -11.111  14.231  1.00 93.95           C  \\nATOM    677  CZ  PHE A  84       0.672 -11.645  15.504  1.00 93.95           C  \\nATOM    678  N   ARG A  85       3.247  -7.892  14.241  1.00 94.81           N  \\nATOM    679  CA  ARG A  85       3.332  -7.064  15.443  1.00 94.81           C  \\nATOM    680  C   ARG A  85       2.214  -7.413  16.412  1.00 94.81           C  \\nATOM    681  CB  ARG A  85       3.386  -5.592  15.019  1.00 94.81           C  \\nATOM    682  O   ARG A  85       1.058  -7.528  16.021  1.00 94.81           O  \\nATOM    683  CG  ARG A  85       3.421  -4.616  16.203  1.00 94.81           C  \\nATOM    684  CD  ARG A  85       3.621  -3.170  15.740  1.00 94.81           C  \\nATOM    685  NE  ARG A  85       2.551  -2.727  14.831  1.00 94.81           N  \\nATOM    686  NH1 ARG A  85       2.901  -0.465  15.004  1.00 94.81           N  \\nATOM    687  NH2 ARG A  85       1.274  -1.265  13.703  1.00 94.81           N  \\nATOM    688  CZ  ARG A  85       2.247  -1.485  14.525  1.00 94.81           C  \\nATOM    689  N   VAL A  86       2.580  -7.543  17.683  1.00 95.89           N  \\nATOM    690  CA  VAL A  86       1.651  -7.722  18.804  1.00 95.89           C  \\nATOM    691  C   VAL A  86       1.692  -6.456  19.646  1.00 95.89           C  \\nATOM    692  CB  VAL A  86       2.003  -8.958  19.655  1.00 95.89           C  \\nATOM    693  O   VAL A  86       2.780  -5.970  19.970  1.00 95.89           O  \\nATOM    694  CG1 VAL A  86       0.912  -9.222  20.701  1.00 95.89           C  \\nATOM    695  CG2 VAL A  86       2.147 -10.224  18.803  1.00 95.89           C  \\nATOM    696  N   MET A  87       0.529  -5.904  19.985  1.00 94.97           N  \\nATOM    697  CA  MET A  87       0.415  -4.683  20.776  1.00 94.97           C  \\nATOM    698  C   MET A  87      -0.579  -4.839  21.918  1.00 94.97           C  \\nATOM    699  CB  MET A  87       0.029  -3.467  19.920  1.00 94.97           C  \\nATOM    700  O   MET A  87      -1.655  -5.398  21.750  1.00 94.97           O  \\nATOM    701  CG  MET A  87       0.864  -3.339  18.644  1.00 94.97           C  \\nATOM    702  SD  MET A  87       0.705  -1.824  17.654  1.00 94.97           S  \\nATOM    703  CE  MET A  87       0.605  -0.482  18.868  1.00 94.97           C  \\nATOM    704  N   LEU A  88      -0.239  -4.282  23.074  1.00 94.38           N  \\nATOM    705  CA  LEU A  88      -1.184  -3.960  24.134  1.00 94.38           C  \\nATOM    706  C   LEU A  88      -1.552  -2.487  23.998  1.00 94.38           C  \\nATOM    707  CB  LEU A  88      -0.542  -4.265  25.494  1.00 94.38           C  \\nATOM    708  O   LEU A  88      -0.677  -1.623  24.088  1.00 94.38           O  \\nATOM    709  CG  LEU A  88      -1.435  -3.908  26.697  1.00 94.38           C  \\nATOM    710  CD1 LEU A  88      -2.645  -4.832  26.821  1.00 94.38           C  \\nATOM    711  CD2 LEU A  88      -0.604  -4.001  27.979  1.00 94.38           C  \\nATOM    712  N   VAL A  89      -2.836  -2.211  23.826  1.00 92.51           N  \\nATOM    713  CA  VAL A  89      -3.389  -0.868  23.693  1.00 92.51           C  \\nATOM    714  C   VAL A  89      -4.299  -0.605  24.881  1.00 92.51           C  \\nATOM    715  CB  VAL A  89      -4.144  -0.711  22.363  1.00 92.51           C  \\nATOM    716  O   VAL A  89      -5.257  -1.334  25.120  1.00 92.51           O  \\nATOM    717  CG1 VAL A  89      -4.593   0.742  22.180  1.00 92.51           C  \\nATOM    718  CG2 VAL A  89      -3.265  -1.101  21.165  1.00 92.51           C  \\nATOM    719  N   LYS A  90      -3.989   0.436  25.645  1.00 90.91           N  \\nATOM    720  CA  LYS A  90      -4.807   0.892  26.766  1.00 90.91           C  \\nATOM    721  C   LYS A  90      -5.536   2.152  26.353  1.00 90.91           C  \\nATOM    722  CB  LYS A  90      -3.947   1.139  28.001  1.00 90.91           C  \\nATOM    723  O   LYS A  90      -4.880   3.149  26.052  1.00 90.91           O  \\nATOM    724  CG  LYS A  90      -3.127  -0.098  28.367  1.00 90.91           C  \\nATOM    725  CD  LYS A  90      -2.585   0.066  29.783  1.00 90.91           C  \\nATOM    726  CE  LYS A  90      -2.041  -1.277  30.255  1.00 90.91           C  \\nATOM    727  NZ  LYS A  90      -2.758  -1.692  31.472  1.00 90.91           N  \\nATOM    728  N   VAL A  91      -6.858   2.088  26.338  1.00 87.42           N  \\nATOM    729  CA  VAL A  91      -7.745   3.178  25.941  1.00 87.42           C  \\nATOM    730  C   VAL A  91      -8.497   3.657  27.181  1.00 87.42           C  \\nATOM    731  CB  VAL A  91      -8.708   2.713  24.828  1.00 87.42           C  \\nATOM    732  O   VAL A  91      -9.071   2.846  27.907  1.00 87.42           O  \\nATOM    733  CG1 VAL A  91      -9.447   3.918  24.253  1.00 87.42           C  \\nATOM    734  CG2 VAL A  91      -7.986   2.032  23.655  1.00 87.42           C  \\nATOM    735  N   GLY A  92      -8.473   4.957  27.466  1.00 83.02           N  \\nATOM    736  CA  GLY A  92      -9.228   5.527  28.583  1.00 83.02           C  \\nATOM    737  C   GLY A  92      -8.793   6.936  28.972  1.00 83.02           C  \\nATOM    738  O   GLY A  92      -7.907   7.524  28.350  1.00 83.02           O  \\nATOM    739  N   GLU A  93      -9.405   7.467  30.030  1.00 67.59           N  \\nATOM    740  CA  GLU A  93      -9.097   8.799  30.558  1.00 67.59           C  \\nATOM    741  C   GLU A  93      -7.637   8.892  31.036  1.00 67.59           C  \\nATOM    742  CB  GLU A  93     -10.073   9.182  31.683  1.00 67.59           C  \\nATOM    743  O   GLU A  93      -7.160   8.097  31.850  1.00 67.59           O  \\nATOM    744  CG  GLU A  93     -11.504   9.412  31.162  1.00 67.59           C  \\nATOM    745  CD  GLU A  93     -12.493   9.859  32.256  1.00 67.59           C  \\nATOM    746  OE1 GLU A  93     -13.673  10.080  31.905  1.00 67.59           O  \\nATOM    747  OE2 GLU A  93     -12.086   9.947  33.438  1.00 67.59           O  \\nATOM    748  N   GLY A  94      -6.906   9.858  30.484  1.00 63.49           N  \\nATOM    749  CA  GLY A  94      -5.564  10.235  30.909  1.00 63.49           C  \\nATOM    750  C   GLY A  94      -5.568  11.108  32.168  1.00 63.49           C  \\nATOM    751  O   GLY A  94      -6.610  11.432  32.732  1.00 63.49           O  \\nATOM    752  N   GLU A  95      -4.376  11.519  32.605  1.00 60.01           N  \\nATOM    753  CA  GLU A  95      -4.169  12.233  33.880  1.00 60.01           C  \\nATOM    754  C   GLU A  95      -4.857  13.610  33.942  1.00 60.01           C  \\nATOM    755  CB  GLU A  95      -2.655  12.364  34.144  1.00 60.01           C  \\nATOM    756  O   GLU A  95      -5.232  14.056  35.023  1.00 60.01           O  \\nATOM    757  CG  GLU A  95      -2.016  10.999  34.460  1.00 60.01           C  \\nATOM    758  CD  GLU A  95      -0.484  11.015  34.594  1.00 60.01           C  \\nATOM    759  OE1 GLU A  95       0.085   9.894  34.546  1.00 60.01           O  \\nATOM    760  OE2 GLU A  95       0.116  12.104  34.706  1.00 60.01           O  \\nATOM    761  N   GLU A  96      -5.076  14.261  32.797  1.00 61.24           N  \\nATOM    762  CA  GLU A  96      -5.698  15.592  32.699  1.00 61.24           C  \\nATOM    763  C   GLU A  96      -7.176  15.542  32.264  1.00 61.24           C  \\nATOM    764  CB  GLU A  96      -4.857  16.499  31.783  1.00 61.24           C  \\nATOM    765  O   GLU A  96      -7.721  16.532  31.780  1.00 61.24           O  \\nATOM    766  CG  GLU A  96      -3.432  16.721  32.318  1.00 61.24           C  \\nATOM    767  CD  GLU A  96      -2.623  17.735  31.490  1.00 61.24           C  \\nATOM    768  OE1 GLU A  96      -1.516  18.093  31.955  1.00 61.24           O  \\nATOM    769  OE2 GLU A  96      -3.105  18.160  30.415  1.00 61.24           O  \\nATOM    770  N   GLY A  97      -7.827  14.376  32.362  1.00 58.18           N  \\nATOM    771  CA  GLY A  97      -9.180  14.163  31.826  1.00 58.18           C  \\nATOM    772  C   GLY A  97      -9.241  14.126  30.292  1.00 58.18           C  \\nATOM    773  O   GLY A  97     -10.313  13.956  29.719  1.00 58.18           O  \\nATOM    774  N   GLN A  98      -8.097  14.260  29.612  1.00 64.07           N  \\nATOM    775  CA  GLN A  98      -7.980  14.019  28.178  1.00 64.07           C  \\nATOM    776  C   GLN A  98      -7.915  12.522  27.916  1.00 64.07           C  \\nATOM    777  CB  GLN A  98      -6.740  14.699  27.590  1.00 64.07           C  \\nATOM    778  O   GLN A  98      -7.146  11.802  28.554  1.00 64.07           O  \\nATOM    779  CG  GLN A  98      -6.845  16.228  27.634  1.00 64.07           C  \\nATOM    780  CD  GLN A  98      -5.653  16.912  26.973  1.00 64.07           C  \\nATOM    781  NE2 GLN A  98      -5.462  18.187  27.212  1.00 64.07           N  \\nATOM    782  OE1 GLN A  98      -4.873  16.329  26.239  1.00 64.07           O  \\nATOM    783  N   TRP A  99      -8.696  12.052  26.955  1.00 69.84           N  \\nATOM    784  CA  TRP A  99      -8.648  10.664  26.529  1.00 69.84           C  \\nATOM    785  C   TRP A  99      -7.264  10.308  25.981  1.00 69.84           C  \\nATOM    786  CB  TRP A  99      -9.739  10.436  25.498  1.00 69.84           C  \\nATOM    787  O   TRP A  99      -6.682  11.051  25.188  1.00 69.84           O  \\nATOM    788  CG  TRP A  99     -10.150   9.015  25.386  1.00 69.84           C  \\nATOM    789  CD1 TRP A  99      -9.580   8.013  24.675  1.00 69.84           C  \\nATOM    790  CD2 TRP A  99     -11.203   8.393  26.155  1.00 69.84           C  \\nATOM    791  CE2 TRP A  99     -11.328   7.061  25.701  1.00 69.84           C  \\nATOM    792  CE3 TRP A  99     -12.035   8.802  27.216  1.00 69.84           C  \\nATOM    793  NE1 TRP A  99     -10.362   6.896  24.752  1.00 69.84           N  \\nATOM    794  CH2 TRP A  99     -13.103   6.625  27.263  1.00 69.84           C  \\nATOM    795  CZ2 TRP A  99     -12.271   6.206  26.224  1.00 69.84           C  \\nATOM    796  CZ3 TRP A  99     -12.973   7.920  27.776  1.00 69.84           C  \\nATOM    797  N   SER A 100      -6.716   9.176  26.417  1.00 78.58           N  \\nATOM    798  CA  SER A 100      -5.363   8.749  26.077  1.00 78.58           C  \\nATOM    799  C   SER A 100      -5.345   7.323  25.543  1.00 78.58           C  \\nATOM    800  CB  SER A 100      -4.414   8.943  27.268  1.00 78.58           C  \\nATOM    801  O   SER A 100      -6.096   6.453  25.990  1.00 78.58           O  \\nATOM    802  OG  SER A 100      -4.623   7.989  28.295  1.00 78.58           O  \\nATOM    803  N   VAL A 101      -4.451   7.088  24.584  1.00 82.75           N  \\nATOM    804  CA  VAL A 101      -4.159   5.758  24.055  1.00 82.75           C  \\nATOM    805  C   VAL A 101      -2.692   5.457  24.334  1.00 82.75           C  \\nATOM    806  CB  VAL A 101      -4.513   5.643  22.562  1.00 82.75           C  \\nATOM    807  O   VAL A 101      -1.807   6.075  23.749  1.00 82.75           O  \\nATOM    808  CG1 VAL A 101      -4.293   4.201  22.105  1.00 82.75           C  \\nATOM    809  CG2 VAL A 101      -5.985   5.997  22.300  1.00 82.75           C  \\nATOM    810  N   LYS A 102      -2.423   4.536  25.264  1.00 86.97           N  \\nATOM    811  CA  LYS A 102      -1.056   4.106  25.604  1.00 86.97           C  \\nATOM    812  C   LYS A 102      -0.782   2.746  24.979  1.00 86.97           C  \\nATOM    813  CB  LYS A 102      -0.831   4.095  27.128  1.00 86.97           C  \\nATOM    814  O   LYS A 102      -1.544   1.807  25.209  1.00 86.97           O  \\nATOM    815  CG  LYS A 102      -0.908   5.500  27.749  1.00 86.97           C  \\nATOM    816  CD  LYS A 102      -0.643   5.494  29.266  1.00 86.97           C  \\nATOM    817  CE  LYS A 102      -0.780   6.930  29.805  1.00 86.97           C  \\nATOM    818  NZ  LYS A 102      -0.582   7.047  31.278  1.00 86.97           N  \\nATOM    819  N   THR A 103       0.319   2.621  24.244  1.00 90.69           N  \\nATOM    820  CA  THR A 103       0.684   1.382  23.552  1.00 90.69           C  \\nATOM    821  C   THR A 103       1.960   0.762  24.123  1.00 90.69           C  \\nATOM    822  CB  THR A 103       0.774   1.580  22.028  1.00 90.69           C  \\nATOM    823  O   THR A 103       2.858   1.438  24.628  1.00 90.69           O  \\nATOM    824  CG2 THR A 103      -0.538   2.111  21.447  1.00 90.69           C  \\nATOM    825  OG1 THR A 103       1.787   2.495  21.715  1.00 90.69           O  \\nATOM    826  N   LYS A 104       2.033  -0.568  24.075  1.00 92.29           N  \\nATOM    827  CA  LYS A 104       3.275  -1.346  24.165  1.00 92.29           C  \\nATOM    828  C   LYS A 104       3.258  -2.337  23.021  1.00 92.29           C  \\nATOM    829  CB  LYS A 104       3.378  -2.110  25.491  1.00 92.29           C  \\nATOM    830  O   LYS A 104       2.251  -3.019  22.861  1.00 92.29           O  \\nATOM    831  CG  LYS A 104       3.511  -1.192  26.706  1.00 92.29           C  \\nATOM    832  CD  LYS A 104       3.719  -2.047  27.958  1.00 92.29           C  \\nATOM    833  CE  LYS A 104       3.883  -1.142  29.178  1.00 92.29           C  \\nATOM    834  NZ  LYS A 104       4.209  -1.941  30.384  1.00 92.29           N  \\nATOM    835  N   HIS A 105       4.337  -2.449  22.260  1.00 93.29           N  \\nATOM    836  CA  HIS A 105       4.371  -3.336  21.104  1.00 93.29           C  \\nATOM    837  C   HIS A 105       5.654  -4.157  21.033  1.00 93.29           C  \\nATOM    838  CB  HIS A 105       4.129  -2.526  19.823  1.00 93.29           C  \\nATOM    839  O   HIS A 105       6.687  -3.784  21.587  1.00 93.29           O  \\nATOM    840  CG  HIS A 105       5.251  -1.604  19.433  1.00 93.29           C  \\nATOM    841  CD2 HIS A 105       6.396  -1.977  18.783  1.00 93.29           C  \\nATOM    842  ND1 HIS A 105       5.304  -0.236  19.591  1.00 93.29           N  \\nATOM    843  CE1 HIS A 105       6.458   0.191  19.059  1.00 93.29           C  \\nATOM    844  NE2 HIS A 105       7.160  -0.835  18.551  1.00 93.29           N  \\nATOM    845  N   GLN A 106       5.584  -5.267  20.304  1.00 94.47           N  \\nATOM    846  CA  GLN A 106       6.743  -6.044  19.890  1.00 94.47           C  \\nATOM    847  C   GLN A 106       6.576  -6.468  18.432  1.00 94.47           C  \\nATOM    848  CB  GLN A 106       6.920  -7.238  20.833  1.00 94.47           C  \\nATOM    849  O   GLN A 106       5.506  -6.925  18.029  1.00 94.47           O  \\nATOM    850  CG  GLN A 106       8.252  -7.964  20.603  1.00 94.47           C  \\nATOM    851  CD  GLN A 106       8.509  -9.058  21.633  1.00 94.47           C  \\nATOM    852  NE2 GLN A 106       9.227 -10.094  21.258  1.00 94.47           N  \\nATOM    853  OE1 GLN A 106       8.106  -9.006  22.784  1.00 94.47           O  \\nATOM    854  N   MET A 107       7.638  -6.292  17.646  1.00 93.56           N  \\nATOM    855  CA  MET A 107       7.704  -6.727  16.252  1.00 93.56           C  \\nATOM    856  C   MET A 107       8.435  -8.064  16.138  1.00 93.56           C  \\nATOM    857  CB  MET A 107       8.395  -5.671  15.380  1.00 93.56           C  \\nATOM    858  O   MET A 107       9.413  -8.310  16.845  1.00 93.56           O  \\nATOM    859  CG  MET A 107       7.578  -4.381  15.261  1.00 93.56           C  \\nATOM    860  SD  MET A 107       8.280  -3.169  14.108  1.00 93.56           S  \\nATOM    861  CE  MET A 107       9.740  -2.627  15.039  1.00 93.56           C  \\nATOM    862  N   TYR A 108       7.973  -8.885  15.205  1.00 95.20           N  \\nATOM    863  CA  TYR A 108       8.491 -10.202  14.874  1.00 95.20           C  \\nATOM    864  C   TYR A 108       8.672 -10.292  13.355  1.00 95.20           C  \\nATOM    865  CB  TYR A 108       7.512 -11.272  15.380  1.00 95.20           C  \\nATOM    866  O   TYR A 108       7.773  -9.935  12.591  1.00 95.20           O  \\nATOM    867  CG  TYR A 108       7.264 -11.252  16.878  1.00 95.20           C  \\nATOM    868  CD1 TYR A 108       8.013 -12.092  17.725  1.00 95.20           C  \\nATOM    869  CD2 TYR A 108       6.263 -10.420  17.417  1.00 95.20           C  \\nATOM    870  CE1 TYR A 108       7.751 -12.112  19.108  1.00 95.20           C  \\nATOM    871  CE2 TYR A 108       6.013 -10.423  18.801  1.00 95.20           C  \\nATOM    872  OH  TYR A 108       6.503 -11.261  20.978  1.00 95.20           O  \\nATOM    873  CZ  TYR A 108       6.747 -11.277  19.646  1.00 95.20           C  \\nATOM    874  N   SER A 109       9.839 -10.753  12.908  1.00 92.97           N  \\nATOM    875  CA  SER A 109      10.088 -11.039  11.491  1.00 92.97           C  \\nATOM    876  C   SER A 109       9.464 -12.378  11.130  1.00 92.97           C  \\nATOM    877  CB  SER A 109      11.588 -11.117  11.200  1.00 92.97           C  \\nATOM    878  O   SER A 109       9.809 -13.381  11.746  1.00 92.97           O  \\nATOM    879  OG  SER A 109      12.216  -9.884  11.488  1.00 92.97           O  \\nATOM    880  N   ILE A 110       8.595 -12.406  10.124  1.00 90.72           N  \\nATOM    881  CA  ILE A 110       7.926 -13.642   9.707  1.00 90.72           C  \\nATOM    882  C   ILE A 110       8.910 -14.476   8.868  1.00 90.72           C  \\nATOM    883  CB  ILE A 110       6.621 -13.350   8.941  1.00 90.72           C  \\nATOM    884  O   ILE A 110       9.429 -13.961   7.875  1.00 90.72           O  \\nATOM    885  CG1 ILE A 110       5.714 -12.380   9.735  1.00 90.72           C  \\nATOM    886  CG2 ILE A 110       5.868 -14.669   8.678  1.00 90.72           C  \\nATOM    887  CD1 ILE A 110       4.573 -11.818   8.890  1.00 90.72           C  \\nATOM    888  N   PRO A 111       9.189 -15.737   9.239  1.00 91.62           N  \\nATOM    889  CA  PRO A 111      10.029 -16.629   8.445  1.00 91.62           C  \\nATOM    890  C   PRO A 111       9.454 -16.893   7.042  1.00 91.62           C  \\nATOM    891  CB  PRO A 111      10.124 -17.910   9.275  1.00 91.62           C  \\nATOM    892  O   PRO A 111       8.239 -16.995   6.866  1.00 91.62           O  \\nATOM    893  CG  PRO A 111       9.904 -17.450  10.709  1.00 91.62           C  \\nATOM    894  CD  PRO A 111       8.857 -16.363  10.511  1.00 91.62           C  \\nATOM    895  N   GLU A 112      10.317 -17.031   6.032  1.00 89.42           N  \\nATOM    896  CA  GLU A 112       9.898 -17.234   4.632  1.00 89.42           C  \\nATOM    897  C   GLU A 112       9.109 -18.541   4.432  1.00 89.42           C  \\nATOM    898  CB  GLU A 112      11.150 -17.205   3.737  1.00 89.42           C  \\nATOM    899  O   GLU A 112       8.141 -18.589   3.667  1.00 89.42           O  \\nATOM    900  CG  GLU A 112      10.818 -17.260   2.235  1.00 89.42           C  \\nATOM    901  CD  GLU A 112      12.053 -17.140   1.324  1.00 89.42           C  \\nATOM    902  OE1 GLU A 112      11.845 -17.074   0.090  1.00 89.42           O  \\nATOM    903  OE2 GLU A 112      13.192 -17.104   1.845  1.00 89.42           O  \\nATOM    904  N   ASP A 113       9.471 -19.591   5.166  1.00 91.72           N  \\nATOM    905  CA  ASP A 113       8.769 -20.873   5.193  1.00 91.72           C  \\nATOM    906  C   ASP A 113       7.382 -20.766   5.841  1.00 91.72           C  \\nATOM    907  CB  ASP A 113       9.643 -21.929   5.896  1.00 91.72           C  \\nATOM    908  O   ASP A 113       6.448 -21.422   5.384  1.00 91.72           O  \\nATOM    909  CG  ASP A 113       9.973 -21.619   7.363  1.00 91.72           C  \\nATOM    910  OD1 ASP A 113      10.089 -20.419   7.695  1.00 91.72           O  \\nATOM    911  OD2 ASP A 113      10.148 -22.587   8.132  1.00 91.72           O  \\nATOM    912  N   ALA A 114       7.192 -19.887   6.829  1.00 92.79           N  \\nATOM    913  CA  ALA A 114       5.863 -19.575   7.359  1.00 92.79           C  \\nATOM    914  C   ALA A 114       5.014 -18.782   6.345  1.00 92.79           C  \\nATOM    915  CB  ALA A 114       6.013 -18.838   8.695  1.00 92.79           C  \\nATOM    916  O   ALA A 114       3.817 -19.027   6.213  1.00 92.79           O  \\nATOM    917  N   MET A 115       5.620 -17.867   5.579  1.00 89.91           N  \\nATOM    918  CA  MET A 115       4.913 -17.082   4.551  1.00 89.91           C  \\nATOM    919  C   MET A 115       4.460 -17.925   3.349  1.00 89.91           C  \\nATOM    920  CB  MET A 115       5.811 -15.945   4.039  1.00 89.91           C  \\nATOM    921  O   MET A 115       3.453 -17.602   2.712  1.00 89.91           O  \\nATOM    922  CG  MET A 115       6.109 -14.894   5.111  1.00 89.91           C  \\nATOM    923  SD  MET A 115       7.233 -13.560   4.611  1.00 89.91           S  \\nATOM    924  CE  MET A 115       6.362 -12.886   3.176  1.00 89.91           C  \\nATOM    925  N   THR A 116       5.212 -18.975   3.010  1.00 91.53           N  \\nATOM    926  CA  THR A 116       5.031 -19.771   1.780  1.00 91.53           C  \\nATOM    927  C   THR A 116       4.622 -21.226   2.019  1.00 91.53           C  \\nATOM    928  CB  THR A 116       6.292 -19.721   0.903  1.00 91.53           C  \\nATOM    929  O   THR A 116       4.306 -21.928   1.060  1.00 91.53           O  \\nATOM    930  CG2 THR A 116       6.633 -18.301   0.447  1.00 91.53           C  \\nATOM    931  OG1 THR A 116       7.406 -20.237   1.591  1.00 91.53           O  \\nATOM    932  N   GLY A 117       4.601 -21.679   3.275  1.00 93.72           N  \\nATOM    933  CA  GLY A 117       4.248 -23.038   3.676  1.00 93.72           C  \\nATOM    934  C   GLY A 117       2.739 -23.283   3.742  1.00 93.72           C  \\nATOM    935  O   GLY A 117       2.009 -23.126   2.761  1.00 93.72           O  \\nATOM    936  N   THR A 118       2.253 -23.721   4.902  1.00 96.96           N  \\nATOM    937  CA  THR A 118       0.822 -23.972   5.144  1.00 96.96           C  \\nATOM    938  C   THR A 118       0.217 -22.896   6.039  1.00 96.96           C  \\nATOM    939  CB  THR A 118       0.571 -25.363   5.744  1.00 96.96           C  \\nATOM    940  O   THR A 118       0.921 -22.227   6.794  1.00 96.96           O  \\nATOM    941  CG2 THR A 118       1.183 -26.497   4.923  1.00 96.96           C  \\nATOM    942  OG1 THR A 118       1.105 -25.439   7.041  1.00 96.96           O  \\nATOM    943  N   ALA A 119      -1.107 -22.748   5.988  1.00 96.77           N  \\nATOM    944  CA  ALA A 119      -1.842 -21.903   6.919  1.00 96.77           C  \\nATOM    945  C   ALA A 119      -1.529 -22.282   8.373  1.00 96.77           C  \\nATOM    946  CB  ALA A 119      -3.337 -22.044   6.619  1.00 96.77           C  \\nATOM    947  O   ALA A 119      -1.260 -21.406   9.186  1.00 96.77           O  \\nATOM    948  N   GLU A 120      -1.486 -23.580   8.690  1.00 97.51           N  \\nATOM    949  CA  GLU A 120      -1.136 -24.060  10.030  1.00 97.51           C  \\nATOM    950  C   GLU A 120       0.232 -23.533  10.483  1.00 97.51           C  \\nATOM    951  CB  GLU A 120      -1.211 -25.594  10.061  1.00 97.51           C  \\nATOM    952  O   GLU A 120       0.312 -22.933  11.549  1.00 97.51           O  \\nATOM    953  CG  GLU A 120      -0.963 -26.155  11.467  1.00 97.51           C  \\nATOM    954  CD  GLU A 120      -1.308 -27.648  11.542  1.00 97.51           C  \\nATOM    955  OE1 GLU A 120      -0.373 -28.478  11.591  1.00 97.51           O  \\nATOM    956  OE2 GLU A 120      -2.524 -27.956  11.528  1.00 97.51           O  \\nATOM    957  N   MET A 121       1.271 -23.635   9.643  1.00 96.57           N  \\nATOM    958  CA  MET A 121       2.605 -23.103   9.962  1.00 96.57           C  \\nATOM    959  C   MET A 121       2.583 -21.595  10.248  1.00 96.57           C  \\nATOM    960  CB  MET A 121       3.578 -23.374   8.806  1.00 96.57           C  \\nATOM    961  O   MET A 121       3.187 -21.142  11.221  1.00 96.57           O  \\nATOM    962  CG  MET A 121       3.945 -24.853   8.660  1.00 96.57           C  \\nATOM    963  SD  MET A 121       4.807 -25.246   7.108  1.00 96.57           S  \\nATOM    964  CE  MET A 121       6.349 -24.311   7.349  1.00 96.57           C  \\nATOM    965  N   LEU A 122       1.876 -20.813   9.425  1.00 96.86           N  \\nATOM    966  CA  LEU A 122       1.774 -19.363   9.602  1.00 96.86           C  \\nATOM    967  C   LEU A 122       1.052 -18.994  10.905  1.00 96.86           C  \\nATOM    968  CB  LEU A 122       1.067 -18.753   8.377  1.00 96.86           C  \\nATOM    969  O   LEU A 122       1.539 -18.163  11.672  1.00 96.86           O  \\nATOM    970  CG  LEU A 122       0.884 -17.224   8.447  1.00 96.86           C  \\nATOM    971  CD1 LEU A 122       2.209 -16.465   8.572  1.00 96.86           C  \\nATOM    972  CD2 LEU A 122       0.167 -16.738   7.187  1.00 96.86           C  \\nATOM    973  N   PHE A 123      -0.111 -19.595  11.164  1.00 97.37           N  \\nATOM    974  CA  PHE A 123      -0.923 -19.254  12.333  1.00 97.37           C  \\nATOM    975  C   PHE A 123      -0.349 -19.825  13.639  1.00 97.37           C  \\nATOM    976  CB  PHE A 123      -2.394 -19.627  12.094  1.00 97.37           C  \\nATOM    977  O   PHE A 123      -0.483 -19.184  14.683  1.00 97.37           O  \\nATOM    978  CG  PHE A 123      -3.096 -18.705  11.108  1.00 97.37           C  \\nATOM    979  CD1 PHE A 123      -3.516 -17.425  11.517  1.00 97.37           C  \\nATOM    980  CD2 PHE A 123      -3.329 -19.105   9.780  1.00 97.37           C  \\nATOM    981  CE1 PHE A 123      -4.135 -16.556  10.599  1.00 97.37           C  \\nATOM    982  CE2 PHE A 123      -3.905 -18.226   8.850  1.00 97.37           C  \\nATOM    983  CZ  PHE A 123      -4.313 -16.950   9.261  1.00 97.37           C  \\nATOM    984  N   ASP A 124       0.362 -20.954  13.598  1.00 97.60           N  \\nATOM    985  CA  ASP A 124       1.089 -21.490  14.755  1.00 97.60           C  \\nATOM    986  C   ASP A 124       2.281 -20.594  15.134  1.00 97.60           C  \\nATOM    987  CB  ASP A 124       1.547 -22.934  14.488  1.00 97.60           C  \\nATOM    988  O   ASP A 124       2.507 -20.352  16.328  1.00 97.60           O  \\nATOM    989  CG  ASP A 124       0.421 -23.981  14.569  1.00 97.60           C  \\nATOM    990  OD1 ASP A 124      -0.773 -23.623  14.738  1.00 97.60           O  \\nATOM    991  OD2 ASP A 124       0.747 -25.184  14.551  1.00 97.60           O  \\nATOM    992  N   TYR A 125       2.981 -20.032  14.137  1.00 96.76           N  \\nATOM    993  CA  TYR A 125       4.011 -19.008  14.343  1.00 96.76           C  \\nATOM    994  C   TYR A 125       3.419 -17.724  14.943  1.00 96.76           C  \\nATOM    995  CB  TYR A 125       4.731 -18.714  13.017  1.00 96.76           C  \\nATOM    996  O   TYR A 125       3.923 -17.213  15.942  1.00 96.76           O  \\nATOM    997  CG  TYR A 125       5.762 -17.611  13.144  1.00 96.76           C  \\nATOM    998  CD1 TYR A 125       5.441 -16.288  12.774  1.00 96.76           C  \\nATOM    999  CD2 TYR A 125       7.012 -17.900  13.720  1.00 96.76           C  \\nATOM   1000  CE1 TYR A 125       6.360 -15.250  13.015  1.00 96.76           C  \\nATOM   1001  CE2 TYR A 125       7.939 -16.869  13.950  1.00 96.76           C  \\nATOM   1002  OH  TYR A 125       8.469 -14.538  13.899  1.00 96.76           O  \\nATOM   1003  CZ  TYR A 125       7.600 -15.540  13.621  1.00 96.76           C  \\nATOM   1004  N   ILE A 126       2.296 -17.234  14.404  1.00 96.63           N  \\nATOM   1005  CA  ILE A 126       1.570 -16.081  14.968  1.00 96.63           C  \\nATOM   1006  C   ILE A 126       1.200 -16.339  16.437  1.00 96.63           C  \\nATOM   1007  CB  ILE A 126       0.329 -15.767  14.099  1.00 96.63           C  \\nATOM   1008  O   ILE A 126       1.434 -15.488  17.297  1.00 96.63           O  \\nATOM   1009  CG1 ILE A 126       0.767 -15.108  12.772  1.00 96.63           C  \\nATOM   1010  CG2 ILE A 126      -0.685 -14.881  14.843  1.00 96.63           C  \\nATOM   1011  CD1 ILE A 126      -0.345 -15.053  11.714  1.00 96.63           C  \\nATOM   1012  N   SER A 127       0.672 -17.527  16.746  1.00 96.46           N  \\nATOM   1013  CA  SER A 127       0.353 -17.945  18.115  1.00 96.46           C  \\nATOM   1014  C   SER A 127       1.592 -17.963  19.025  1.00 96.46           C  \\nATOM   1015  CB  SER A 127      -0.320 -19.321  18.066  1.00 96.46           C  \\nATOM   1016  O   SER A 127       1.500 -17.594  20.197  1.00 96.46           O  \\nATOM   1017  OG  SER A 127      -0.643 -19.767  19.368  1.00 96.46           O  \\nATOM   1018  N   GLU A 128       2.765 -18.328  18.497  1.00 96.97           N  \\nATOM   1019  CA  GLU A 128       4.042 -18.264  19.223  1.00 96.97           C  \\nATOM   1020  C   GLU A 128       4.414 -16.844  19.618  1.00 96.97           C  \\nATOM   1021  CB  GLU A 128       5.185 -18.847  18.375  1.00 96.97           C  \\nATOM   1022  O   GLU A 128       4.709 -16.579  20.783  1.00 96.97           O  \\nATOM   1023  CG  GLU A 128       6.360 -19.253  19.273  1.00 96.97           C  \\nATOM   1024  CD  GLU A 128       7.435 -20.027  18.506  1.00 96.97           C  \\nATOM   1025  OE1 GLU A 128       8.624 -19.867  18.858  1.00 96.97           O  \\nATOM   1026  OE2 GLU A 128       7.040 -20.847  17.650  1.00 96.97           O  \\nATOM   1027  N   CYS A 129       4.354 -15.923  18.658  1.00 96.98           N  \\nATOM   1028  CA  CYS A 129       4.657 -14.518  18.886  1.00 96.98           C  \\nATOM   1029  C   CYS A 129       3.718 -13.908  19.933  1.00 96.98           C  \\nATOM   1030  CB  CYS A 129       4.526 -13.785  17.552  1.00 96.98           C  \\nATOM   1031  O   CYS A 129       4.158 -13.163  20.807  1.00 96.98           O  \\nATOM   1032  SG  CYS A 129       5.733 -14.396  16.350  1.00 96.98           S  \\nATOM   1033  N   ILE A 130       2.431 -14.260  19.885  1.00 96.16           N  \\nATOM   1034  CA  ILE A 130       1.457 -13.840  20.895  1.00 96.16           C  \\nATOM   1035  C   ILE A 130       1.848 -14.375  22.278  1.00 96.16           C  \\nATOM   1036  CB  ILE A 130       0.046 -14.301  20.492  1.00 96.16           C  \\nATOM   1037  O   ILE A 130       1.899 -13.603  23.235  1.00 96.16           O  \\nATOM   1038  CG1 ILE A 130      -0.430 -13.587  19.210  1.00 96.16           C  \\nATOM   1039  CG2 ILE A 130      -0.940 -14.026  21.632  1.00 96.16           C  \\nATOM   1040  CD1 ILE A 130      -1.670 -14.239  18.585  1.00 96.16           C  \\nATOM   1041  N   SER A 131       2.147 -15.673  22.386  1.00 96.18           N  \\nATOM   1042  CA  SER A 131       2.564 -16.310  23.643  1.00 96.18           C  \\nATOM   1043  C   SER A 131       3.792 -15.620  24.251  1.00 96.18           C  \\nATOM   1044  CB  SER A 131       2.868 -17.793  23.400  1.00 96.18           C  \\nATOM   1045  O   SER A 131       3.763 -15.239  25.424  1.00 96.18           O  \\nATOM   1046  OG  SER A 131       3.160 -18.439  24.622  1.00 96.18           O  \\nATOM   1047  N   ASP A 132       4.830 -15.381  23.441  1.00 96.99           N  \\nATOM   1048  CA  ASP A 132       6.058 -14.683  23.844  1.00 96.99           C  \\nATOM   1049  C   ASP A 132       5.769 -13.265  24.360  1.00 96.99           C  \\nATOM   1050  CB  ASP A 132       7.029 -14.648  22.648  1.00 96.99           C  \\nATOM   1051  O   ASP A 132       6.261 -12.866  25.421  1.00 96.99           O  \\nATOM   1052  CG  ASP A 132       8.243 -13.737  22.881  1.00 96.99           C  \\nATOM   1053  OD1 ASP A 132       9.141 -14.044  23.691  1.00 96.99           O  \\nATOM   1054  OD2 ASP A 132       8.328 -12.651  22.254  1.00 96.99           O  \\nATOM   1055  N   PHE A 133       4.926 -12.506  23.653  1.00 96.58           N  \\nATOM   1056  CA  PHE A 133       4.532 -11.167  24.085  1.00 96.58           C  \\nATOM   1057  C   PHE A 133       3.782 -11.198  25.423  1.00 96.58           C  \\nATOM   1058  CB  PHE A 133       3.666 -10.507  23.008  1.00 96.58           C  \\nATOM   1059  O   PHE A 133       4.070 -10.393  26.318  1.00 96.58           O  \\nATOM   1060  CG  PHE A 133       3.266  -9.090  23.367  1.00 96.58           C  \\nATOM   1061  CD1 PHE A 133       2.033  -8.829  23.992  1.00 96.58           C  \\nATOM   1062  CD2 PHE A 133       4.147  -8.032  23.097  1.00 96.58           C  \\nATOM   1063  CE1 PHE A 133       1.680  -7.509  24.325  1.00 96.58           C  \\nATOM   1064  CE2 PHE A 133       3.787  -6.709  23.409  1.00 96.58           C  \\nATOM   1065  CZ  PHE A 133       2.552  -6.448  24.025  1.00 96.58           C  \\nATOM   1066  N   LEU A 134       2.827 -12.122  25.580  1.00 95.45           N  \\nATOM   1067  CA  LEU A 134       2.046 -12.272  26.807  1.00 95.45           C  \\nATOM   1068  C   LEU A 134       2.920 -12.694  27.994  1.00 95.45           C  \\nATOM   1069  CB  LEU A 134       0.905 -13.283  26.592  1.00 95.45           C  \\nATOM   1070  O   LEU A 134       2.705 -12.181  29.093  1.00 95.45           O  \\nATOM   1071  CG  LEU A 134      -0.225 -12.839  25.646  1.00 95.45           C  \\nATOM   1072  CD1 LEU A 134      -1.221 -13.989  25.507  1.00 95.45           C  \\nATOM   1073  CD2 LEU A 134      -0.981 -11.611  26.158  1.00 95.45           C  \\nATOM   1074  N   ASP A 135       3.913 -13.564  27.795  1.00 94.75           N  \\nATOM   1075  CA  ASP A 135       4.872 -13.958  28.837  1.00 94.75           C  \\nATOM   1076  C   ASP A 135       5.711 -12.773  29.313  1.00 94.75           C  \\nATOM   1077  CB  ASP A 135       5.812 -15.067  28.327  1.00 94.75           C  \\nATOM   1078  O   ASP A 135       5.769 -12.487  30.512  1.00 94.75           O  \\nATOM   1079  CG  ASP A 135       5.280 -16.476  28.570  1.00 94.75           C  \\nATOM   1080  OD1 ASP A 135       4.409 -16.649  29.451  1.00 94.75           O  \\nATOM   1081  OD2 ASP A 135       5.734 -17.419  27.890  1.00 94.75           O  \\nATOM   1082  N   LYS A 136       6.301 -12.023  28.374  1.00 95.77           N  \\nATOM   1083  CA  LYS A 136       7.128 -10.841  28.676  1.00 95.77           C  \\nATOM   1084  C   LYS A 136       6.385  -9.780  29.482  1.00 95.77           C  \\nATOM   1085  CB  LYS A 136       7.628 -10.244  27.357  1.00 95.77           C  \\nATOM   1086  O   LYS A 136       6.996  -9.058  30.268  1.00 95.77           O  \\nATOM   1087  CG  LYS A 136       8.795 -11.069  26.813  1.00 95.77           C  \\nATOM   1088  CD  LYS A 136       9.121 -10.660  25.380  1.00 95.77           C  \\nATOM   1089  CE  LYS A 136      10.383 -11.399  24.946  1.00 95.77           C  \\nATOM   1090  NZ  LYS A 136      10.460 -11.481  23.480  1.00 95.77           N  \\nATOM   1091  N   HIS A 137       5.070  -9.704  29.309  1.00 93.86           N  \\nATOM   1092  CA  HIS A 137       4.209  -8.747  29.994  1.00 93.86           C  \\nATOM   1093  C   HIS A 137       3.412  -9.356  31.157  1.00 93.86           C  \\nATOM   1094  CB  HIS A 137       3.322  -8.073  28.948  1.00 93.86           C  \\nATOM   1095  O   HIS A 137       2.634  -8.638  31.785  1.00 93.86           O  \\nATOM   1096  CG  HIS A 137       4.116  -7.244  27.972  1.00 93.86           C  \\nATOM   1097  CD2 HIS A 137       4.439  -5.924  28.100  1.00 93.86           C  \\nATOM   1098  ND1 HIS A 137       4.693  -7.688  26.809  1.00 93.86           N  \\nATOM   1099  CE1 HIS A 137       5.351  -6.660  26.250  1.00 93.86           C  \\nATOM   1100  NE2 HIS A 137       5.219  -5.550  27.004  1.00 93.86           N  \\nATOM   1101  N   GLN A 138       3.608 -10.644  31.467  1.00 93.11           N  \\nATOM   1102  CA  GLN A 138       2.908 -11.377  32.529  1.00 93.11           C  \\nATOM   1103  C   GLN A 138       1.377 -11.333  32.374  1.00 93.11           C  \\nATOM   1104  CB  GLN A 138       3.384 -10.916  33.920  1.00 93.11           C  \\nATOM   1105  O   GLN A 138       0.643 -11.119  33.337  1.00 93.11           O  \\nATOM   1106  CG  GLN A 138       4.904 -11.018  34.104  1.00 93.11           C  \\nATOM   1107  CD  GLN A 138       5.374 -10.412  35.420  1.00 93.11           C  \\nATOM   1108  NE2 GLN A 138       6.639 -10.069  35.521  1.00 93.11           N  \\nATOM   1109  OE1 GLN A 138       4.641 -10.223  36.377  1.00 93.11           O  \\nATOM   1110  N   MET A 139       0.880 -11.518  31.149  1.00 91.67           N  \\nATOM   1111  CA  MET A 139      -0.540 -11.371  30.803  1.00 91.67           C  \\nATOM   1112  C   MET A 139      -1.224 -12.661  30.339  1.00 91.67           C  \\nATOM   1113  CB  MET A 139      -0.733 -10.254  29.766  1.00 91.67           C  \\nATOM   1114  O   MET A 139      -2.409 -12.607  30.039  1.00 91.67           O  \\nATOM   1115  CG  MET A 139      -0.239  -8.898  30.271  1.00 91.67           C  \\nATOM   1116  SD  MET A 139      -0.804  -7.467  29.317  1.00 91.67           S  \\nATOM   1117  CE  MET A 139      -0.148  -7.887  27.674  1.00 91.67           C  \\nATOM   1118  N   LYS A 140      -0.552 -13.822  30.325  1.00 90.85           N  \\nATOM   1119  CA  LYS A 140      -1.161 -15.094  29.866  1.00 90.85           C  \\nATOM   1120  C   LYS A 140      -2.451 -15.496  30.588  1.00 90.85           C  \\nATOM   1121  CB  LYS A 140      -0.158 -16.250  29.987  1.00 90.85           C  \\nATOM   1122  O   LYS A 140      -3.299 -16.161  30.011  1.00 90.85           O  \\nATOM   1123  CG  LYS A 140       0.869 -16.224  28.855  1.00 90.85           C  \\nATOM   1124  CD  LYS A 140       1.590 -17.570  28.759  1.00 90.85           C  \\nATOM   1125  CE  LYS A 140       2.455 -17.531  27.503  1.00 90.85           C  \\nATOM   1126  NZ  LYS A 140       3.405 -18.656  27.438  1.00 90.85           N  \\nATOM   1127  N   HIS A 141      -2.607 -15.081  31.843  1.00 89.02           N  \\nATOM   1128  CA  HIS A 141      -3.799 -15.353  32.650  1.00 89.02           C  \\nATOM   1129  C   HIS A 141      -4.969 -14.394  32.360  1.00 89.02           C  \\nATOM   1130  CB  HIS A 141      -3.401 -15.313  34.133  1.00 89.02           C  \\nATOM   1131  O   HIS A 141      -6.046 -14.558  32.931  1.00 89.02           O  \\nATOM   1132  CG  HIS A 141      -2.929 -13.953  34.590  1.00 89.02           C  \\nATOM   1133  CD2 HIS A 141      -3.707 -12.958  35.121  1.00 89.02           C  \\nATOM   1134  ND1 HIS A 141      -1.640 -13.470  34.533  1.00 89.02           N  \\nATOM   1135  CE1 HIS A 141      -1.644 -12.221  35.028  1.00 89.02           C  \\nATOM   1136  NE2 HIS A 141      -2.884 -11.857  35.387  1.00 89.02           N  \\nATOM   1137  N   LYS A 142      -4.764 -13.362  31.531  1.00 88.35           N  \\nATOM   1138  CA  LYS A 142      -5.791 -12.380  31.178  1.00 88.35           C  \\nATOM   1139  C   LYS A 142      -6.439 -12.750  29.852  1.00 88.35           C  \\nATOM   1140  CB  LYS A 142      -5.203 -10.967  31.080  1.00 88.35           C  \\nATOM   1141  O   LYS A 142      -5.751 -12.922  28.852  1.00 88.35           O  \\nATOM   1142  CG  LYS A 142      -4.638 -10.457  32.410  1.00 88.35           C  \\nATOM   1143  CD  LYS A 142      -4.281  -8.977  32.261  1.00 88.35           C  \\nATOM   1144  CE  LYS A 142      -3.834  -8.400  33.602  1.00 88.35           C  \\nATOM   1145  NZ  LYS A 142      -3.636  -6.936  33.485  1.00 88.35           N  \\nATOM   1146  N   LYS A 143      -7.769 -12.754  29.831  1.00 88.59           N  \\nATOM   1147  CA  LYS A 143      -8.562 -12.848  28.605  1.00 88.59           C  \\nATOM   1148  C   LYS A 143      -8.906 -11.439  28.128  1.00 88.59           C  \\nATOM   1149  CB  LYS A 143      -9.781 -13.732  28.888  1.00 88.59           C  \\nATOM   1150  O   LYS A 143      -9.872 -10.848  28.602  1.00 88.59           O  \\nATOM   1151  CG  LYS A 143     -10.524 -14.105  27.600  1.00 88.59           C  \\nATOM   1152  CD  LYS A 143     -11.547 -15.199  27.917  1.00 88.59           C  \\nATOM   1153  CE  LYS A 143     -12.169 -15.751  26.636  1.00 88.59           C  \\nATOM   1154  NZ  LYS A 143     -12.660 -17.130  26.866  1.00 88.59           N  \\nATOM   1155  N   LEU A 144      -8.053 -10.874  27.275  1.00 90.45           N  \\nATOM   1156  CA  LEU A 144      -8.263  -9.543  26.696  1.00 90.45           C  \\nATOM   1157  C   LEU A 144      -9.009  -9.651  25.356  1.00 90.45           C  \\nATOM   1158  CB  LEU A 144      -6.925  -8.802  26.519  1.00 90.45           C  \\nATOM   1159  O   LEU A 144      -8.735 -10.594  24.604  1.00 90.45           O  \\nATOM   1160  CG  LEU A 144      -6.157  -8.521  27.823  1.00 90.45           C  \\nATOM   1161  CD1 LEU A 144      -4.837  -7.818  27.500  1.00 90.45           C  \\nATOM   1162  CD2 LEU A 144      -6.939  -7.637  28.798  1.00 90.45           C  \\nATOM   1163  N   PRO A 145      -9.888  -8.688  25.023  1.00 93.29           N  \\nATOM   1164  CA  PRO A 145     -10.429  -8.575  23.677  1.00 93.29           C  \\nATOM   1165  C   PRO A 145      -9.300  -8.293  22.680  1.00 93.29           C  \\nATOM   1166  CB  PRO A 145     -11.464  -7.447  23.713  1.00 93.29           C  \\nATOM   1167  O   PRO A 145      -8.414  -7.469  22.936  1.00 93.29           O  \\nATOM   1168  CG  PRO A 145     -11.717  -7.194  25.198  1.00 93.29           C  \\nATOM   1169  CD  PRO A 145     -10.413  -7.621  25.864  1.00 93.29           C  \\nATOM   1170  N   LEU A 146      -9.336  -8.991  21.549  1.00 94.81           N  \\nATOM   1171  CA  LEU A 146      -8.313  -8.976  20.515  1.00 94.81           C  \\nATOM   1172  C   LEU A 146      -8.862  -8.355  19.229  1.00 94.81           C  \\nATOM   1173  CB  LEU A 146      -7.815 -10.415  20.290  1.00 94.81           C  \\nATOM   1174  O   LEU A 146      -9.843  -8.845  18.670  1.00 94.81           O  \\nATOM   1175  CG  LEU A 146      -6.631 -10.525  19.312  1.00 94.81           C  \\nATOM   1176  CD1 LEU A 146      -5.394  -9.971  20.000  1.00 94.81           C  \\nATOM   1177  CD2 LEU A 146      -6.361 -11.979  18.916  1.00 94.81           C  \\nATOM   1178  N   GLY A 147      -8.204  -7.301  18.750  1.00 95.81           N  \\nATOM   1179  CA  GLY A 147      -8.372  -6.796  17.387  1.00 95.81           C  \\nATOM   1180  C   GLY A 147      -7.305  -7.369  16.462  1.00 95.81           C  \\nATOM   1181  O   GLY A 147      -6.125  -7.355  16.805  1.00 95.81           O  \\nATOM   1182  N   PHE A 148      -7.686  -7.860  15.290  1.00 96.33           N  \\nATOM   1183  CA  PHE A 148      -6.737  -8.404  14.323  1.00 96.33           C  \\nATOM   1184  C   PHE A 148      -6.710  -7.569  13.043  1.00 96.33           C  \\nATOM   1185  CB  PHE A 148      -7.054  -9.884  14.067  1.00 96.33           C  \\nATOM   1186  O   PHE A 148      -7.629  -7.628  12.233  1.00 96.33           O  \\nATOM   1187  CG  PHE A 148      -6.043 -10.653  13.228  1.00 96.33           C  \\nATOM   1188  CD1 PHE A 148      -6.383 -11.938  12.766  1.00 96.33           C  \\nATOM   1189  CD2 PHE A 148      -4.762 -10.139  12.929  1.00 96.33           C  \\nATOM   1190  CE1 PHE A 148      -5.450 -12.704  12.045  1.00 96.33           C  \\nATOM   1191  CE2 PHE A 148      -3.834 -10.901  12.207  1.00 96.33           C  \\nATOM   1192  CZ  PHE A 148      -4.172 -12.191  11.772  1.00 96.33           C  \\nATOM   1193  N   THR A 149      -5.630  -6.821  12.837  1.00 96.08           N  \\nATOM   1194  CA  THR A 149      -5.325  -6.211  11.546  1.00 96.08           C  \\nATOM   1195  C   THR A 149      -4.693  -7.240  10.617  1.00 96.08           C  \\nATOM   1196  CB  THR A 149      -4.450  -4.965  11.675  1.00 96.08           C  \\nATOM   1197  O   THR A 149      -3.586  -7.728  10.859  1.00 96.08           O  \\nATOM   1198  CG2 THR A 149      -4.217  -4.332  10.309  1.00 96.08           C  \\nATOM   1199  OG1 THR A 149      -5.159  -4.026  12.435  1.00 96.08           O  \\nATOM   1200  N   PHE A 150      -5.408  -7.563   9.545  1.00 95.11           N  \\nATOM   1201  CA  PHE A 150      -4.999  -8.516   8.527  1.00 95.11           C  \\nATOM   1202  C   PHE A 150      -4.970  -7.819   7.163  1.00 95.11           C  \\nATOM   1203  CB  PHE A 150      -5.940  -9.721   8.593  1.00 95.11           C  \\nATOM   1204  O   PHE A 150      -5.999  -7.538   6.554  1.00 95.11           O  \\nATOM   1205  CG  PHE A 150      -5.504 -10.878   7.726  1.00 95.11           C  \\nATOM   1206  CD1 PHE A 150      -6.120 -11.085   6.485  1.00 95.11           C  \\nATOM   1207  CD2 PHE A 150      -4.518 -11.776   8.175  1.00 95.11           C  \\nATOM   1208  CE1 PHE A 150      -5.802 -12.219   5.726  1.00 95.11           C  \\nATOM   1209  CE2 PHE A 150      -4.177 -12.898   7.397  1.00 95.11           C  \\nATOM   1210  CZ  PHE A 150      -4.821 -13.121   6.169  1.00 95.11           C  \\nATOM   1211  N   SER A 151      -3.763  -7.510   6.690  1.00 91.12           N  \\nATOM   1212  CA  SER A 151      -3.502  -6.617   5.552  1.00 91.12           C  \\nATOM   1213  C   SER A 151      -3.790  -7.205   4.159  1.00 91.12           C  \\nATOM   1214  CB  SER A 151      -2.034  -6.189   5.621  1.00 91.12           C  \\nATOM   1215  O   SER A 151      -3.229  -6.718   3.172  1.00 91.12           O  \\nATOM   1216  OG  SER A 151      -1.750  -5.412   6.754  1.00 91.12           O  \\nATOM   1217  N   PHE A 152      -4.583  -8.269   4.051  1.00 92.53           N  \\nATOM   1218  CA  PHE A 152      -4.833  -8.985   2.794  1.00 92.53           C  \\nATOM   1219  C   PHE A 152      -6.312  -8.903   2.393  1.00 92.53           C  \\nATOM   1220  CB  PHE A 152      -4.361 -10.441   2.913  1.00 92.53           C  \\nATOM   1221  O   PHE A 152      -7.150  -8.660   3.266  1.00 92.53           O  \\nATOM   1222  CG  PHE A 152      -2.912 -10.590   3.322  1.00 92.53           C  \\nATOM   1223  CD1 PHE A 152      -1.904 -10.635   2.343  1.00 92.53           C  \\nATOM   1224  CD2 PHE A 152      -2.572 -10.648   4.686  1.00 92.53           C  \\nATOM   1225  CE1 PHE A 152      -0.559 -10.757   2.731  1.00 92.53           C  \\nATOM   1226  CE2 PHE A 152      -1.226 -10.744   5.072  1.00 92.53           C  \\nATOM   1227  CZ  PHE A 152      -0.223 -10.803   4.094  1.00 92.53           C  \\nATOM   1228  N   PRO A 153      -6.644  -9.130   1.107  1.00 93.17           N  \\nATOM   1229  CA  PRO A 153      -8.023  -9.109   0.630  1.00 93.17           C  \\nATOM   1230  C   PRO A 153      -8.895 -10.139   1.356  1.00 93.17           C  \\nATOM   1231  CB  PRO A 153      -7.957  -9.383  -0.878  1.00 93.17           C  \\nATOM   1232  O   PRO A 153      -8.706 -11.352   1.225  1.00 93.17           O  \\nATOM   1233  CG  PRO A 153      -6.537  -8.994  -1.269  1.00 93.17           C  \\nATOM   1234  CD  PRO A 153      -5.728  -9.301  -0.015  1.00 93.17           C  \\nATOM   1235  N   VAL A 154      -9.874  -9.656   2.118  1.00 95.00           N  \\nATOM   1236  CA  VAL A 154     -10.784 -10.488   2.909  1.00 95.00           C  \\nATOM   1237  C   VAL A 154     -12.225 -10.116   2.608  1.00 95.00           C  \\nATOM   1238  CB  VAL A 154     -10.484 -10.364   4.413  1.00 95.00           C  \\nATOM   1239  O   VAL A 154     -12.623  -8.960   2.740  1.00 95.00           O  \\nATOM   1240  CG1 VAL A 154     -11.575 -11.009   5.267  1.00 95.00           C  \\nATOM   1241  CG2 VAL A 154      -9.184 -11.090   4.775  1.00 95.00           C  \\nATOM   1242  N   ARG A 155     -13.038 -11.122   2.279  1.00 94.21           N  \\nATOM   1243  CA  ARG A 155     -14.493 -10.980   2.264  1.00 94.21           C  \\nATOM   1244  C   ARG A 155     -15.014 -11.188   3.679  1.00 94.21           C  \\nATOM   1245  CB  ARG A 155     -15.103 -11.949   1.248  1.00 94.21           C  \\nATOM   1246  O   ARG A 155     -14.997 -12.311   4.189  1.00 94.21           O  \\nATOM   1247  CG  ARG A 155     -16.630 -11.800   1.156  1.00 94.21           C  \\nATOM   1248  CD  ARG A 155     -17.236 -12.737   0.100  1.00 94.21           C  \\nATOM   1249  NE  ARG A 155     -17.040 -14.169   0.425  1.00 94.21           N  \\nATOM   1250  NH1 ARG A 155     -18.614 -14.358   2.106  1.00 94.21           N  \\nATOM   1251  NH2 ARG A 155     -17.379 -16.089   1.640  1.00 94.21           N  \\nATOM   1252  CZ  ARG A 155     -17.673 -14.854   1.366  1.00 94.21           C  \\nATOM   1253  N   HIS A 156     -15.466 -10.110   4.305  1.00 92.55           N  \\nATOM   1254  CA  HIS A 156     -16.102 -10.180   5.612  1.00 92.55           C  \\nATOM   1255  C   HIS A 156     -17.515 -10.758   5.501  1.00 92.55           C  \\nATOM   1256  CB  HIS A 156     -16.083  -8.808   6.286  1.00 92.55           C  \\nATOM   1257  O   HIS A 156     -18.271 -10.441   4.584  1.00 92.55           O  \\nATOM   1258  CG  HIS A 156     -14.714  -8.445   6.791  1.00 92.55           C  \\nATOM   1259  CD2 HIS A 156     -13.663  -7.940   6.069  1.00 92.55           C  \\nATOM   1260  ND1 HIS A 156     -14.278  -8.634   8.079  1.00 92.55           N  \\nATOM   1261  CE1 HIS A 156     -12.992  -8.252   8.134  1.00 92.55           C  \\nATOM   1262  NE2 HIS A 156     -12.565  -7.834   6.931  1.00 92.55           N  \\nATOM   1263  N   GLU A 157     -17.849 -11.623   6.449  1.00 89.34           N  \\nATOM   1264  CA  GLU A 157     -19.216 -12.085   6.709  1.00 89.34           C  \\nATOM   1265  C   GLU A 157     -19.757 -11.481   8.011  1.00 89.34           C  \\nATOM   1266  CB  GLU A 157     -19.236 -13.621   6.764  1.00 89.34           C  \\nATOM   1267  O   GLU A 157     -20.966 -11.379   8.174  1.00 89.34           O  \\nATOM   1268  CG  GLU A 157     -18.929 -14.235   5.390  1.00 89.34           C  \\nATOM   1269  CD  GLU A 157     -18.975 -15.768   5.344  1.00 89.34           C  \\nATOM   1270  OE1 GLU A 157     -18.757 -16.292   4.222  1.00 89.34           O  \\nATOM   1271  OE2 GLU A 157     -19.204 -16.421   6.392  1.00 89.34           O  \\nATOM   1272  N   ASP A 158     -18.858 -11.077   8.913  1.00 88.25           N  \\nATOM   1273  CA  ASP A 158     -19.132 -10.303  10.123  1.00 88.25           C  \\nATOM   1274  C   ASP A 158     -17.843  -9.559  10.547  1.00 88.25           C  \\nATOM   1275  CB  ASP A 158     -19.638 -11.246  11.236  1.00 88.25           C  \\nATOM   1276  O   ASP A 158     -16.779  -9.727   9.935  1.00 88.25           O  \\nATOM   1277  CG  ASP A 158     -20.550 -10.549  12.258  1.00 88.25           C  \\nATOM   1278  OD1 ASP A 158     -20.465  -9.303  12.380  1.00 88.25           O  \\nATOM   1279  OD2 ASP A 158     -21.333 -11.271  12.912  1.00 88.25           O  \\nATOM   1280  N   ILE A 159     -17.902  -8.761  11.615  1.00 88.43           N  \\nATOM   1281  CA  ILE A 159     -16.758  -8.007  12.144  1.00 88.43           C  \\nATOM   1282  C   ILE A 159     -15.617  -8.913  12.633  1.00 88.43           C  \\nATOM   1283  CB  ILE A 159     -17.232  -7.020  13.233  1.00 88.43           C  \\nATOM   1284  O   ILE A 159     -14.456  -8.522  12.552  1.00 88.43           O  \\nATOM   1285  CG1 ILE A 159     -16.140  -5.964  13.514  1.00 88.43           C  \\nATOM   1286  CG2 ILE A 159     -17.670  -7.741  14.523  1.00 88.43           C  \\nATOM   1287  CD1 ILE A 159     -16.657  -4.740  14.279  1.00 88.43           C  \\nATOM   1288  N   ASP A 160     -15.907 -10.134  13.093  1.00 89.61           N  \\nATOM   1289  CA  ASP A 160     -14.925 -11.126  13.557  1.00 89.61           C  \\nATOM   1290  C   ASP A 160     -14.847 -12.372  12.649  1.00 89.61           C  \\nATOM   1291  CB  ASP A 160     -15.194 -11.490  15.030  1.00 89.61           C  \\nATOM   1292  O   ASP A 160     -14.254 -13.391  13.017  1.00 89.61           O  \\nATOM   1293  CG  ASP A 160     -16.297 -12.545  15.194  1.00 89.61           C  \\nATOM   1294  OD1 ASP A 160     -17.256 -12.506  14.393  1.00 89.61           O  \\nATOM   1295  OD2 ASP A 160     -16.128 -13.445  16.060  1.00 89.61           O  \\nATOM   1296  N   LYS A 161     -15.427 -12.305  11.444  1.00 92.80           N  \\nATOM   1297  CA  LYS A 161     -15.452 -13.417  10.489  1.00 92.80           C  \\nATOM   1298  C   LYS A 161     -15.117 -12.928   9.092  1.00 92.80           C  \\nATOM   1299  CB  LYS A 161     -16.830 -14.088  10.545  1.00 92.80           C  \\nATOM   1300  O   LYS A 161     -15.904 -12.228   8.459  1.00 92.80           O  \\nATOM   1301  CG  LYS A 161     -16.839 -15.405   9.759  1.00 92.80           C  \\nATOM   1302  CD  LYS A 161     -18.239 -16.017   9.781  1.00 92.80           C  \\nATOM   1303  CE  LYS A 161     -18.228 -17.384   9.094  1.00 92.80           C  \\nATOM   1304  NZ  LYS A 161     -19.588 -17.745   8.644  1.00 92.80           N  \\nATOM   1305  N   GLY A 162     -13.975 -13.362   8.571  1.00 94.95           N  \\nATOM   1306  CA  GLY A 162     -13.576 -13.003   7.218  1.00 94.95           C  \\nATOM   1307  C   GLY A 162     -12.820 -14.110   6.509  1.00 94.95           C  \\nATOM   1308  O   GLY A 162     -11.969 -14.791   7.086  1.00 94.95           O  \\nATOM   1309  N   ILE A 163     -13.182 -14.286   5.244  1.00 97.38           N  \\nATOM   1310  CA  ILE A 163     -12.644 -15.297   4.348  1.00 97.38           C  \\nATOM   1311  C   ILE A 163     -11.537 -14.663   3.514  1.00 97.38           C  \\nATOM   1312  CB  ILE A 163     -13.776 -15.880   3.474  1.00 97.38           C  \\nATOM   1313  O   ILE A 163     -11.797 -13.709   2.777  1.00 97.38           O  \\nATOM   1314  CG1 ILE A 163     -14.998 -16.363   4.292  1.00 97.38           C  \\nATOM   1315  CG2 ILE A 163     -13.227 -17.025   2.613  1.00 97.38           C  \\nATOM   1316  CD1 ILE A 163     -14.693 -17.337   5.439  1.00 97.38           C  \\nATOM   1317  N   LEU A 164     -10.312 -15.185   3.620  1.00 96.73           N  \\nATOM   1318  CA  LEU A 164      -9.215 -14.743   2.759  1.00 96.73           C  \\nATOM   1319  C   LEU A 164      -9.559 -15.075   1.304  1.00 96.73           C  \\nATOM   1320  CB  LEU A 164      -7.898 -15.400   3.209  1.00 96.73           C  \\nATOM   1321  O   LEU A 164      -9.832 -16.233   0.987  1.00 96.73           O  \\nATOM   1322  CG  LEU A 164      -6.719 -15.139   2.251  1.00 96.73           C  \\nATOM   1323  CD1 LEU A 164      -6.249 -13.688   2.226  1.00 96.73           C  \\nATOM   1324  CD2 LEU A 164      -5.515 -15.969   2.662  1.00 96.73           C  \\nATOM   1325  N   LEU A 165      -9.533 -14.074   0.427  1.00 94.26           N  \\nATOM   1326  CA  LEU A 165      -9.818 -14.265  -0.995  1.00 94.26           C  \\nATOM   1327  C   LEU A 165      -8.589 -14.794  -1.728  1.00 94.26           C  \\nATOM   1328  CB  LEU A 165     -10.316 -12.945  -1.606  1.00 94.26           C  \\nATOM   1329  O   LEU A 165      -8.634 -15.856  -2.341  1.00 94.26           O  \\nATOM   1330  CG  LEU A 165     -11.676 -12.475  -1.066  1.00 94.26           C  \\nATOM   1331  CD1 LEU A 165     -12.042 -11.139  -1.709  1.00 94.26           C  \\nATOM   1332  CD2 LEU A 165     -12.778 -13.496  -1.369  1.00 94.26           C  \\nATOM   1333  N   ASN A 166      -7.486 -14.063  -1.622  1.00 91.65           N  \\nATOM   1334  CA  ASN A 166      -6.234 -14.385  -2.281  1.00 91.65           C  \\nATOM   1335  C   ASN A 166      -5.067 -13.754  -1.522  1.00 91.65           C  \\nATOM   1336  CB  ASN A 166      -6.291 -13.911  -3.744  1.00 91.65           C  \\nATOM   1337  O   ASN A 166      -5.181 -12.656  -0.972  1.00 91.65           O  \\nATOM   1338  CG  ASN A 166      -6.509 -12.415  -3.872  1.00 91.65           C  \\nATOM   1339  ND2 ASN A 166      -5.471 -11.658  -4.138  1.00 91.65           N  \\nATOM   1340  OD1 ASN A 166      -7.603 -11.899  -3.709  1.00 91.65           O  \\nATOM   1341  N   TRP A 167      -3.923 -14.425  -1.519  1.00 90.40           N  \\nATOM   1342  CA  TRP A 167      -2.702 -13.856  -0.981  1.00 90.40           C  \\nATOM   1343  C   TRP A 167      -2.137 -12.768  -1.897  1.00 90.40           C  \\nATOM   1344  CB  TRP A 167      -1.666 -14.944  -0.717  1.00 90.40           C  \\nATOM   1345  O   TRP A 167      -2.183 -12.839  -3.126  1.00 90.40           O  \\nATOM   1346  CG  TRP A 167      -1.952 -15.845   0.440  1.00 90.40           C  \\nATOM   1347  CD1 TRP A 167      -2.144 -17.180   0.375  1.00 90.40           C  \\nATOM   1348  CD2 TRP A 167      -2.079 -15.488   1.848  1.00 90.40           C  \\nATOM   1349  CE2 TRP A 167      -2.278 -16.682   2.600  1.00 90.40           C  \\nATOM   1350  CE3 TRP A 167      -2.045 -14.274   2.568  1.00 90.40           C  \\nATOM   1351  NE1 TRP A 167      -2.307 -17.682   1.651  1.00 90.40           N  \\nATOM   1352  CH2 TRP A 167      -2.369 -15.447   4.683  1.00 90.40           C  \\nATOM   1353  CZ2 TRP A 167      -2.393 -16.670   3.999  1.00 90.40           C  \\nATOM   1354  CZ3 TRP A 167      -2.200 -14.253   3.966  1.00 90.40           C  \\nATOM   1355  N   THR A 168      -1.539 -11.759  -1.272  1.00 85.13           N  \\nATOM   1356  CA  THR A 168      -0.785 -10.689  -1.934  1.00 85.13           C  \\nATOM   1357  C   THR A 168       0.541 -10.491  -1.202  1.00 85.13           C  \\nATOM   1358  CB  THR A 168      -1.600  -9.384  -2.016  1.00 85.13           C  \\nATOM   1359  O   THR A 168       0.911 -11.282  -0.329  1.00 85.13           O  \\nATOM   1360  CG2 THR A 168      -2.957  -9.564  -2.690  1.00 85.13           C  \\nATOM   1361  OG1 THR A 168      -1.817  -8.853  -0.732  1.00 85.13           O  \\nATOM   1362  N   LYS A 169       1.328  -9.473  -1.576  1.00 82.52           N  \\nATOM   1363  CA  LYS A 169       2.564  -9.086  -0.863  1.00 82.52           C  \\nATOM   1364  C   LYS A 169       3.621 -10.204  -0.744  1.00 82.52           C  \\nATOM   1365  CB  LYS A 169       2.193  -8.440   0.496  1.00 82.52           C  \\nATOM   1366  O   LYS A 169       4.656  -9.999  -0.122  1.00 82.52           O  \\nATOM   1367  CG  LYS A 169       1.319  -7.176   0.333  1.00 82.52           C  \\nATOM   1368  CD  LYS A 169       0.618  -6.732   1.630  1.00 82.52           C  \\nATOM   1369  CE  LYS A 169      -0.258  -5.505   1.312  1.00 82.52           C  \\nATOM   1370  NZ  LYS A 169      -1.140  -5.081   2.433  1.00 82.52           N  \\nATOM   1371  N   GLY A 170       3.480 -11.314  -1.480  1.00 80.61           N  \\nATOM   1372  CA  GLY A 170       4.427 -12.442  -1.535  1.00 80.61           C  \\nATOM   1373  C   GLY A 170       4.076 -13.641  -0.655  1.00 80.61           C  \\nATOM   1374  O   GLY A 170       4.806 -14.625  -0.697  1.00 80.61           O  \\nATOM   1375  N   PHE A 171       2.982 -13.578   0.103  1.00 89.34           N  \\nATOM   1376  CA  PHE A 171       2.478 -14.728   0.851  1.00 89.34           C  \\nATOM   1377  C   PHE A 171       1.916 -15.785  -0.104  1.00 89.34           C  \\nATOM   1378  CB  PHE A 171       1.424 -14.265   1.862  1.00 89.34           C  \\nATOM   1379  O   PHE A 171       1.406 -15.445  -1.172  1.00 89.34           O  \\nATOM   1380  CG  PHE A 171       2.015 -13.628   3.103  1.00 89.34           C  \\nATOM   1381  CD1 PHE A 171       1.962 -14.315   4.331  1.00 89.34           C  \\nATOM   1382  CD2 PHE A 171       2.633 -12.363   3.037  1.00 89.34           C  \\nATOM   1383  CE1 PHE A 171       2.509 -13.736   5.488  1.00 89.34           C  \\nATOM   1384  CE2 PHE A 171       3.192 -11.792   4.194  1.00 89.34           C  \\nATOM   1385  CZ  PHE A 171       3.122 -12.474   5.418  1.00 89.34           C  \\nATOM   1386  N   LYS A 172       2.035 -17.062   0.277  1.00 89.79           N  \\nATOM   1387  CA  LYS A 172       1.477 -18.227  -0.436  1.00 89.79           C  \\nATOM   1388  C   LYS A 172       1.079 -19.367   0.511  1.00 89.79           C  \\nATOM   1389  CB  LYS A 172       2.446 -18.730  -1.530  1.00 89.79           C  \\nATOM   1390  O   LYS A 172       1.045 -20.520   0.094  1.00 89.79           O  \\nATOM   1391  CG  LYS A 172       2.618 -17.729  -2.677  1.00 89.79           C  \\nATOM   1392  CD  LYS A 172       3.224 -18.370  -3.928  1.00 89.79           C  \\nATOM   1393  CE  LYS A 172       3.239 -17.287  -5.008  1.00 89.79           C  \\nATOM   1394  NZ  LYS A 172       3.507 -17.816  -6.365  1.00 89.79           N  \\nATOM   1395  N   ALA A 173       0.804 -19.066   1.781  1.00 93.22           N  \\nATOM   1396  CA  ALA A 173       0.477 -20.078   2.781  1.00 93.22           C  \\nATOM   1397  C   ALA A 173      -0.770 -20.884   2.365  1.00 93.22           C  \\nATOM   1398  CB  ALA A 173       0.332 -19.407   4.151  1.00 93.22           C  \\nATOM   1399  O   ALA A 173      -1.904 -20.393   2.370  1.00 93.22           O  \\nATOM   1400  N   SER A 174      -0.544 -22.132   1.965  1.00 95.32           N  \\nATOM   1401  CA  SER A 174      -1.569 -23.014   1.409  1.00 95.32           C  \\nATOM   1402  C   SER A 174      -2.645 -23.366   2.441  1.00 95.32           C  \\nATOM   1403  CB  SER A 174      -0.923 -24.271   0.817  1.00 95.32           C  \\nATOM   1404  O   SER A 174      -2.359 -23.548   3.624  1.00 95.32           O  \\nATOM   1405  OG  SER A 174      -0.124 -24.945   1.771  1.00 95.32           O  \\nATOM   1406  N   GLY A 175      -3.902 -23.451   2.000  1.00 95.88           N  \\nATOM   1407  CA  GLY A 175      -5.046 -23.744   2.872  1.00 95.88           C  \\nATOM   1408  C   GLY A 175      -5.612 -22.540   3.634  1.00 95.88           C  \\nATOM   1409  O   GLY A 175      -6.574 -22.708   4.374  1.00 95.88           O  \\nATOM   1410  N   ALA A 176      -5.055 -21.336   3.462  1.00 96.06           N  \\nATOM   1411  CA  ALA A 176      -5.637 -20.123   4.037  1.00 96.06           C  \\nATOM   1412  C   ALA A 176      -6.679 -19.477   3.112  1.00 96.06           C  \\nATOM   1413  CB  ALA A 176      -4.514 -19.146   4.358  1.00 96.06           C  \\nATOM   1414  O   ALA A 176      -7.714 -19.014   3.585  1.00 96.06           O  \\nATOM   1415  N   GLU A 177      -6.421 -19.449   1.800  1.00 96.13           N  \\nATOM   1416  CA  GLU A 177      -7.372 -18.920   0.815  1.00 96.13           C  \\nATOM   1417  C   GLU A 177      -8.678 -19.725   0.863  1.00 96.13           C  \\nATOM   1418  CB  GLU A 177      -6.768 -18.931  -0.598  1.00 96.13           C  \\nATOM   1419  O   GLU A 177      -8.672 -20.947   1.036  1.00 96.13           O  \\nATOM   1420  CG  GLU A 177      -5.578 -17.966  -0.731  1.00 96.13           C  \\nATOM   1421  CD  GLU A 177      -4.924 -17.991  -2.123  1.00 96.13           C  \\nATOM   1422  OE1 GLU A 177      -4.199 -17.017  -2.431  1.00 96.13           O  \\nATOM   1423  OE2 GLU A 177      -5.069 -19.006  -2.838  1.00 96.13           O  \\nATOM   1424  N   GLY A 178      -9.809 -19.027   0.786  1.00 96.55           N  \\nATOM   1425  CA  GLY A 178     -11.143 -19.605   0.940  1.00 96.55           C  \\nATOM   1426  C   GLY A 178     -11.528 -19.983   2.377  1.00 96.55           C  \\nATOM   1427  O   GLY A 178     -12.643 -20.458   2.584  1.00 96.55           O  \\nATOM   1428  N   ASN A 179     -10.665 -19.759   3.376  1.00 97.11           N  \\nATOM   1429  CA  ASN A 179     -10.917 -20.130   4.771  1.00 97.11           C  \\nATOM   1430  C   ASN A 179     -11.054 -18.912   5.696  1.00 97.11           C  \\nATOM   1431  CB  ASN A 179      -9.843 -21.124   5.245  1.00 97.11           C  \\nATOM   1432  O   ASN A 179     -10.570 -17.816   5.409  1.00 97.11           O  \\nATOM   1433  CG  ASN A 179     -10.032 -22.483   4.602  1.00 97.11           C  \\nATOM   1434  ND2 ASN A 179      -9.471 -22.721   3.441  1.00 97.11           N  \\nATOM   1435  OD1 ASN A 179     -10.743 -23.328   5.120  1.00 97.11           O  \\nATOM   1436  N   ASN A 180     -11.733 -19.119   6.831  1.00 96.72           N  \\nATOM   1437  CA  ASN A 180     -11.929 -18.089   7.851  1.00 96.72           C  \\nATOM   1438  C   ASN A 180     -10.626 -17.821   8.616  1.00 96.72           C  \\nATOM   1439  CB  ASN A 180     -13.073 -18.502   8.797  1.00 96.72           C  \\nATOM   1440  O   ASN A 180     -10.203 -18.648   9.425  1.00 96.72           O  \\nATOM   1441  CG  ASN A 180     -13.312 -17.490   9.911  1.00 96.72           C  \\nATOM   1442  ND2 ASN A 180     -14.085 -17.843  10.910  1.00 96.72           N  \\nATOM   1443  OD1 ASN A 180     -12.806 -16.381   9.929  1.00 96.72           O  \\nATOM   1444  N   VAL A 181     -10.046 -16.637   8.421  1.00 96.62           N  \\nATOM   1445  CA  VAL A 181      -8.781 -16.204   9.037  1.00 96.62           C  \\nATOM   1446  C   VAL A 181      -8.849 -16.231  10.566  1.00 96.62           C  \\nATOM   1447  CB  VAL A 181      -8.435 -14.790   8.532  1.00 96.62           C  \\nATOM   1448  O   VAL A 181      -7.937 -16.733  11.224  1.00 96.62           O  \\nATOM   1449  CG1 VAL A 181      -7.224 -14.184   9.245  1.00 96.62           C  \\nATOM   1450  CG2 VAL A 181      -8.149 -14.805   7.025  1.00 96.62           C  \\nATOM   1451  N   VAL A 182      -9.956 -15.759  11.147  1.00 95.63           N  \\nATOM   1452  CA  VAL A 182     -10.154 -15.778  12.604  1.00 95.63           C  \\nATOM   1453  C   VAL A 182     -10.295 -17.210  13.120  1.00 95.63           C  \\nATOM   1454  CB  VAL A 182     -11.363 -14.909  13.003  1.00 95.63           C  \\nATOM   1455  O   VAL A 182      -9.796 -17.527  14.198  1.00 95.63           O  \\nATOM   1456  CG1 VAL A 182     -11.667 -15.016  14.501  1.00 95.63           C  \\nATOM   1457  CG2 VAL A 182     -11.067 -13.446  12.651  1.00 95.63           C  \\nATOM   1458  N   GLY A 183     -10.918 -18.095  12.339  1.00 95.97           N  \\nATOM   1459  CA  GLY A 183     -10.987 -19.527  12.640  1.00 95.97           C  \\nATOM   1460  C   GLY A 183      -9.600 -20.166  12.698  1.00 95.97           C  \\nATOM   1461  O   GLY A 183      -9.263 -20.795  13.696  1.00 95.97           O  \\nATOM   1462  N   LEU A 184      -8.766 -19.914  11.684  1.00 97.06           N  \\nATOM   1463  CA  LEU A 184      -7.391 -20.421  11.619  1.00 97.06           C  \\nATOM   1464  C   LEU A 184      -6.544 -19.950  12.812  1.00 97.06           C  \\nATOM   1465  CB  LEU A 184      -6.747 -19.974  10.294  1.00 97.06           C  \\nATOM   1466  O   LEU A 184      -5.822 -20.749  13.414  1.00 97.06           O  \\nATOM   1467  CG  LEU A 184      -7.382 -20.576   9.027  1.00 97.06           C  \\nATOM   1468  CD1 LEU A 184      -6.853 -19.870   7.780  1.00 97.06           C  \\nATOM   1469  CD2 LEU A 184      -7.074 -22.068   8.895  1.00 97.06           C  \\nATOM   1470  N   LEU A 185      -6.673 -18.676  13.198  1.00 96.68           N  \\nATOM   1471  CA  LEU A 185      -6.004 -18.130  14.379  1.00 96.68           C  \\nATOM   1472  C   LEU A 185      -6.511 -18.776  15.681  1.00 96.68           C  \\nATOM   1473  CB  LEU A 185      -6.186 -16.601  14.387  1.00 96.68           C  \\nATOM   1474  O   LEU A 185      -5.706 -19.158  16.532  1.00 96.68           O  \\nATOM   1475  CG  LEU A 185      -5.550 -15.904  15.604  1.00 96.68           C  \\nATOM   1476  CD1 LEU A 185      -4.038 -16.126  15.682  1.00 96.68           C  \\nATOM   1477  CD2 LEU A 185      -5.810 -14.401  15.539  1.00 96.68           C  \\nATOM   1478  N   ARG A 186      -7.834 -18.926  15.841  1.00 95.31           N  \\nATOM   1479  CA  ARG A 186      -8.446 -19.579  17.014  1.00 95.31           C  \\nATOM   1480  C   ARG A 186      -7.979 -21.032  17.145  1.00 95.31           C  \\nATOM   1481  CB  ARG A 186      -9.986 -19.486  16.939  1.00 95.31           C  \\nATOM   1482  O   ARG A 186      -7.646 -21.463  18.250  1.00 95.31           O  \\nATOM   1483  CG  ARG A 186     -10.549 -18.097  17.314  1.00 95.31           C  \\nATOM   1484  CD  ARG A 186     -12.075 -18.015  17.087  1.00 95.31           C  \\nATOM   1485  NE  ARG A 186     -12.661 -16.704  17.484  1.00 95.31           N  \\nATOM   1486  NH1 ARG A 186     -14.656 -16.815  16.327  1.00 95.31           N  \\nATOM   1487  NH2 ARG A 186     -14.198 -14.969  17.420  1.00 95.31           N  \\nATOM   1488  CZ  ARG A 186     -13.820 -16.174  17.091  1.00 95.31           C  \\nATOM   1489  N   ASP A 187      -7.891 -21.761  16.036  1.00 96.37           N  \\nATOM   1490  CA  ASP A 187      -7.407 -23.141  16.023  1.00 96.37           C  \\nATOM   1491  C   ASP A 187      -5.929 -23.235  16.425  1.00 96.37           C  \\nATOM   1492  CB  ASP A 187      -7.643 -23.775  14.645  1.00 96.37           C  \\nATOM   1493  O   ASP A 187      -5.574 -24.099  17.227  1.00 96.37           O  \\nATOM   1494  CG  ASP A 187      -9.111 -24.089  14.341  1.00 96.37           C  \\nATOM   1495  OD1 ASP A 187      -9.906 -24.215  15.305  1.00 96.37           O  \\nATOM   1496  OD2 ASP A 187      -9.402 -24.303  13.145  1.00 96.37           O  \\nATOM   1497  N   ALA A 188      -5.078 -22.318  15.951  1.00 97.04           N  \\nATOM   1498  CA  ALA A 188      -3.666 -22.259  16.341  1.00 97.04           C  \\nATOM   1499  C   ALA A 188      -3.479 -21.981  17.839  1.00 97.04           C  \\nATOM   1500  CB  ALA A 188      -2.968 -21.200  15.486  1.00 97.04           C  \\nATOM   1501  O   ALA A 188      -2.727 -22.679  18.523  1.00 97.04           O  \\nATOM   1502  N   ILE A 189      -4.223 -21.014  18.383  1.00 95.02           N  \\nATOM   1503  CA  ILE A 189      -4.211 -20.707  19.822  1.00 95.02           C  \\nATOM   1504  C   ILE A 189      -4.666 -21.926  20.634  1.00 95.02           C  \\nATOM   1505  CB  ILE A 189      -5.075 -19.457  20.103  1.00 95.02           C  \\nATOM   1506  O   ILE A 189      -4.026 -22.291  21.621  1.00 95.02           O  \\nATOM   1507  CG1 ILE A 189      -4.421 -18.212  19.458  1.00 95.02           C  \\nATOM   1508  CG2 ILE A 189      -5.259 -19.243  21.619  1.00 95.02           C  \\nATOM   1509  CD1 ILE A 189      -5.347 -16.992  19.402  1.00 95.02           C  \\nATOM   1510  N   LYS A 190      -5.730 -22.608  20.193  1.00 95.16           N  \\nATOM   1511  CA  LYS A 190      -6.240 -23.812  20.856  1.00 95.16           C  \\nATOM   1512  C   LYS A 190      -5.250 -24.979  20.806  1.00 95.16           C  \\nATOM   1513  CB  LYS A 190      -7.585 -24.184  20.227  1.00 95.16           C  \\nATOM   1514  O   LYS A 190      -5.120 -25.682  21.806  1.00 95.16           O  \\nATOM   1515  CG  LYS A 190      -8.245 -25.364  20.950  1.00 95.16           C  \\nATOM   1516  CD  LYS A 190      -9.587 -25.672  20.290  1.00 95.16           C  \\nATOM   1517  CE  LYS A 190     -10.233 -26.884  20.961  1.00 95.16           C  \\nATOM   1518  NZ  LYS A 190     -11.504 -27.219  20.278  1.00 95.16           N  \\nATOM   1519  N   ARG A 191      -4.565 -25.198  19.675  1.00 96.74           N  \\nATOM   1520  CA  ARG A 191      -3.508 -26.219  19.544  1.00 96.74           C  \\nATOM   1521  C   ARG A 191      -2.360 -25.965  20.517  1.00 96.74           C  \\nATOM   1522  CB  ARG A 191      -2.950 -26.258  18.109  1.00 96.74           C  \\nATOM   1523  O   ARG A 191      -1.844 -26.920  21.091  1.00 96.74           O  \\nATOM   1524  CG  ARG A 191      -3.834 -27.023  17.113  1.00 96.74           C  \\nATOM   1525  CD  ARG A 191      -3.109 -27.213  15.768  1.00 96.74           C  \\nATOM   1526  NE  ARG A 191      -2.840 -25.940  15.073  1.00 96.74           N  \\nATOM   1527  NH1 ARG A 191      -4.845 -25.720  13.971  1.00 96.74           N  \\nATOM   1528  NH2 ARG A 191      -3.267 -24.162  13.751  1.00 96.74           N  \\nATOM   1529  CZ  ARG A 191      -3.654 -25.285  14.270  1.00 96.74           C  \\nATOM   1530  N   ARG A 192      -1.984 -24.698  20.718  1.00 94.64           N  \\nATOM   1531  CA  ARG A 192      -0.926 -24.313  21.659  1.00 94.64           C  \\nATOM   1532  C   ARG A 192      -1.342 -24.500  23.122  1.00 94.64           C  \\nATOM   1533  CB  ARG A 192      -0.491 -22.877  21.353  1.00 94.64           C  \\nATOM   1534  O   ARG A 192      -0.592 -25.093  23.892  1.00 94.64           O  \\nATOM   1535  CG  ARG A 192       0.772 -22.530  22.147  1.00 94.64           C  \\nATOM   1536  CD  ARG A 192       1.203 -21.090  21.864  1.00 94.64           C  \\nATOM   1537  NE  ARG A 192       1.872 -21.004  20.555  1.00 94.64           N  \\nATOM   1538  NH1 ARG A 192       3.996 -21.481  21.269  1.00 94.64           N  \\nATOM   1539  NH2 ARG A 192       3.568 -21.408  19.083  1.00 94.64           N  \\nATOM   1540  CZ  ARG A 192       3.135 -21.299  20.306  1.00 94.64           C  \\nATOM   1541  N   GLY A 193      -2.530 -24.022  23.496  1.00 93.23           N  \\nATOM   1542  CA  GLY A 193      -3.185 -24.342  24.771  1.00 93.23           C  \\nATOM   1543  C   GLY A 193      -2.636 -23.666  26.037  1.00 93.23           C  \\nATOM   1544  O   GLY A 193      -3.010 -24.079  27.132  1.00 93.23           O  \\nATOM   1545  N   ASP A 194      -1.772 -22.651  25.932  1.00 93.22           N  \\nATOM   1546  CA  ASP A 194      -1.150 -21.963  27.080  1.00 93.22           C  \\nATOM   1547  C   ASP A 194      -1.712 -20.557  27.374  1.00 93.22           C  \\nATOM   1548  CB  ASP A 194       0.378 -21.949  26.907  1.00 93.22           C  \\nATOM   1549  O   ASP A 194      -1.338 -19.945  28.377  1.00 93.22           O  \\nATOM   1550  CG  ASP A 194       0.866 -21.039  25.777  1.00 93.22           C  \\nATOM   1551  OD1 ASP A 194       0.147 -20.881  24.771  1.00 93.22           O  \\nATOM   1552  OD2 ASP A 194       1.983 -20.483  25.903  1.00 93.22           O  \\nATOM   1553  N   PHE A 195      -2.621 -20.047  26.539  1.00 93.21           N  \\nATOM   1554  CA  PHE A 195      -3.395 -18.826  26.782  1.00 93.21           C  \\nATOM   1555  C   PHE A 195      -4.744 -18.872  26.046  1.00 93.21           C  \\nATOM   1556  CB  PHE A 195      -2.576 -17.583  26.383  1.00 93.21           C  \\nATOM   1557  O   PHE A 195      -4.942 -19.659  25.120  1.00 93.21           O  \\nATOM   1558  CG  PHE A 195      -2.262 -17.477  24.902  1.00 93.21           C  \\nATOM   1559  CD1 PHE A 195      -1.097 -18.062  24.383  1.00 93.21           C  \\nATOM   1560  CD2 PHE A 195      -3.144 -16.812  24.034  1.00 93.21           C  \\nATOM   1561  CE1 PHE A 195      -0.833 -18.013  23.005  1.00 93.21           C  \\nATOM   1562  CE2 PHE A 195      -2.870 -16.760  22.655  1.00 93.21           C  \\nATOM   1563  CZ  PHE A 195      -1.711 -17.355  22.139  1.00 93.21           C  \\nATOM   1564  N   GLU A 196      -5.671 -18.001  26.443  1.00 89.91           N  \\nATOM   1565  CA  GLU A 196      -6.952 -17.799  25.759  1.00 89.91           C  \\nATOM   1566  C   GLU A 196      -7.050 -16.384  25.189  1.00 89.91           C  \\nATOM   1567  CB  GLU A 196      -8.142 -18.035  26.698  1.00 89.91           C  \\nATOM   1568  O   GLU A 196      -6.551 -15.426  25.780  1.00 89.91           O  \\nATOM   1569  CG  GLU A 196      -8.361 -19.506  27.077  1.00 89.91           C  \\nATOM   1570  CD  GLU A 196      -9.680 -19.717  27.846  1.00 89.91           C  \\nATOM   1571  OE1 GLU A 196      -9.804 -20.781  28.488  1.00 89.91           O  \\nATOM   1572  OE2 GLU A 196     -10.590 -18.841  27.763  1.00 89.91           O  \\nATOM   1573  N   MET A 197      -7.752 -16.243  24.065  1.00 86.16           N  \\nATOM   1574  CA  MET A 197      -8.072 -14.947  23.468  1.00 86.16           C  \\nATOM   1575  C   MET A 197      -9.505 -14.904  22.982  1.00 86.16           C  \\nATOM   1576  CB  MET A 197      -7.174 -14.648  22.272  1.00 86.16           C  \\nATOM   1577  O   MET A 197     -10.088 -15.936  22.648  1.00 86.16           O  \\nATOM   1578  CG  MET A 197      -5.728 -14.555  22.701  1.00 86.16           C  \\nATOM   1579  SD  MET A 197      -4.702 -13.979  21.349  1.00 86.16           S  \\nATOM   1580  CE  MET A 197      -3.826 -12.740  22.285  1.00 86.16           C  \\nATOM   1581  N   ASP A 198     -10.027 -13.688  22.891  1.00 88.89           N  \\nATOM   1582  CA  ASP A 198     -11.317 -13.413  22.286  1.00 88.89           C  \\nATOM   1583  C   ASP A 198     -11.131 -12.440  21.119  1.00 88.89           C  \\nATOM   1584  CB  ASP A 198     -12.259 -12.889  23.376  1.00 88.89           C  \\nATOM   1585  O   ASP A 198     -10.946 -11.243  21.328  1.00 88.89           O  \\nATOM   1586  CG  ASP A 198     -13.711 -12.854  22.909  1.00 88.89           C  \\nATOM   1587  OD1 ASP A 198     -14.000 -13.501  21.877  1.00 88.89           O  \\nATOM   1588  OD2 ASP A 198     -14.518 -12.268  23.660  1.00 88.89           O  \\nATOM   1589  N   VAL A 199     -11.084 -12.962  19.888  1.00 93.03           N  \\nATOM   1590  CA  VAL A 199     -11.050 -12.122  18.679  1.00 93.03           C  \\nATOM   1591  C   VAL A 199     -12.428 -11.509  18.510  1.00 93.03           C  \\nATOM   1592  CB  VAL A 199     -10.644 -12.886  17.404  1.00 93.03           C  \\nATOM   1593  O   VAL A 199     -13.359 -12.229  18.159  1.00 93.03           O  \\nATOM   1594  CG1 VAL A 199     -10.545 -11.921  16.211  1.00 93.03           C  \\nATOM   1595  CG2 VAL A 199      -9.285 -13.578  17.545  1.00 93.03           C  \\nATOM   1596  N   VAL A 200     -12.529 -10.206  18.768  1.00 93.35           N  \\nATOM   1597  CA  VAL A 200     -13.789  -9.447  18.718  1.00 93.35           C  \\nATOM   1598  C   VAL A 200     -13.921  -8.611  17.449  1.00 93.35           C  \\nATOM   1599  CB  VAL A 200     -13.957  -8.549  19.958  1.00 93.35           C  \\nATOM   1600  O   VAL A 200     -15.015  -8.170  17.113  1.00 93.35           O  \\nATOM   1601  CG1 VAL A 200     -14.034  -9.375  21.245  1.00 93.35           C  \\nATOM   1602  CG2 VAL A 200     -12.830  -7.518  20.105  1.00 93.35           C  \\nATOM   1603  N   ALA A 201     -12.808  -8.374  16.755  1.00 93.65           N  \\nATOM   1604  CA  ALA A 201     -12.792  -7.673  15.484  1.00 93.65           C  \\nATOM   1605  C   ALA A 201     -11.595  -8.108  14.637  1.00 93.65           C  \\nATOM   1606  CB  ALA A 201     -12.760  -6.160  15.738  1.00 93.65           C  \\nATOM   1607  O   ALA A 201     -10.490  -8.315  15.144  1.00 93.65           O  \\nATOM   1608  N   MET A 202     -11.809  -8.184  13.330  1.00 94.70           N  \\nATOM   1609  CA  MET A 202     -10.775  -8.287  12.317  1.00 94.70           C  \\nATOM   1610  C   MET A 202     -10.983  -7.168  11.300  1.00 94.70           C  \\nATOM   1611  CB  MET A 202     -10.809  -9.673  11.672  1.00 94.70           C  \\nATOM   1612  O   MET A 202     -12.105  -6.920  10.871  1.00 94.70           O  \\nATOM   1613  CG  MET A 202      -9.650  -9.857  10.685  1.00 94.70           C  \\nATOM   1614  SD  MET A 202      -9.585 -11.479   9.893  1.00 94.70           S  \\nATOM   1615  CE  MET A 202     -11.117 -11.403   8.947  1.00 94.70           C  \\nATOM   1616  N   VAL A 203      -9.911  -6.485  10.915  1.00 95.14           N  \\nATOM   1617  CA  VAL A 203      -9.963  -5.352   9.985  1.00 95.14           C  \\nATOM   1618  C   VAL A 203      -8.778  -5.373   9.029  1.00 95.14           C  \\nATOM   1619  CB  VAL A 203     -10.035  -4.004  10.730  1.00 95.14           C  \\nATOM   1620  O   VAL A 203      -7.734  -5.947   9.327  1.00 95.14           O  \\nATOM   1621  CG1 VAL A 203     -11.371  -3.836  11.458  1.00 95.14           C  \\nATOM   1622  CG2 VAL A 203      -8.895  -3.786  11.734  1.00 95.14           C  \\nATOM   1623  N   ASN A 204      -8.923  -4.721   7.878  1.00 94.92           N  \\nATOM   1624  CA  ASN A 204      -7.790  -4.434   7.001  1.00 94.92           C  \\nATOM   1625  C   ASN A 204      -6.929  -3.292   7.580  1.00 94.92           C  \\nATOM   1626  CB  ASN A 204      -8.330  -4.155   5.593  1.00 94.92           C  \\nATOM   1627  O   ASN A 204      -7.413  -2.474   8.367  1.00 94.92           O  \\nATOM   1628  CG  ASN A 204      -7.226  -3.996   4.568  1.00 94.92           C  \\nATOM   1629  ND2 ASN A 204      -6.674  -5.081   4.078  1.00 94.92           N  \\nATOM   1630  OD1 ASN A 204      -6.852  -2.890   4.216  1.00 94.92           O  \\nATOM   1631  N   ASP A 205      -5.657  -3.216   7.183  1.00 94.58           N  \\nATOM   1632  CA  ASP A 205      -4.729  -2.179   7.651  1.00 94.58           C  \\nATOM   1633  C   ASP A 205      -5.177  -0.768   7.279  1.00 94.58           C  \\nATOM   1634  CB  ASP A 205      -3.285  -2.461   7.191  1.00 94.58           C  \\nATOM   1635  O   ASP A 205      -5.083   0.131   8.110  1.00 94.58           O  \\nATOM   1636  CG  ASP A 205      -3.069  -2.737   5.691  1.00 94.58           C  \\nATOM   1637  OD1 ASP A 205      -4.038  -2.723   4.909  1.00 94.58           O  \\nATOM   1638  OD2 ASP A 205      -1.913  -3.055   5.316  1.00 94.58           O  \\nATOM   1639  N   THR A 206      -5.756  -0.586   6.093  1.00 95.88           N  \\nATOM   1640  CA  THR A 206      -6.367   0.690   5.688  1.00 95.88           C  \\nATOM   1641  C   THR A 206      -7.443   1.154   6.674  1.00 95.88           C  \\nATOM   1642  CB  THR A 206      -6.976   0.588   4.285  1.00 95.88           C  \\nATOM   1643  O   THR A 206      -7.415   2.302   7.123  1.00 95.88           O  \\nATOM   1644  CG2 THR A 206      -5.928   0.342   3.206  1.00 95.88           C  \\nATOM   1645  OG1 THR A 206      -7.911  -0.464   4.208  1.00 95.88           O  \\nATOM   1646  N   VAL A 207      -8.342   0.251   7.080  1.00 95.88           N  \\nATOM   1647  CA  VAL A 207      -9.445   0.525   8.018  1.00 95.88           C  \\nATOM   1648  C   VAL A 207      -8.897   0.887   9.388  1.00 95.88           C  \\nATOM   1649  CB  VAL A 207     -10.387  -0.686   8.138  1.00 95.88           C  \\nATOM   1650  O   VAL A 207      -9.314   1.877   9.985  1.00 95.88           O  \\nATOM   1651  CG1 VAL A 207     -11.580  -0.404   9.061  1.00 95.88           C  \\nATOM   1652  CG2 VAL A 207     -10.931  -1.129   6.777  1.00 95.88           C  \\nATOM   1653  N   ALA A 208      -7.921   0.125   9.878  1.00 95.26           N  \\nATOM   1654  CA  ALA A 208      -7.274   0.431  11.143  1.00 95.26           C  \\nATOM   1655  C   ALA A 208      -6.569   1.802  11.105  1.00 95.26           C  \\nATOM   1656  CB  ALA A 208      -6.328  -0.717  11.475  1.00 95.26           C  \\nATOM   1657  O   ALA A 208      -6.763   2.614  12.010  1.00 95.26           O  \\nATOM   1658  N   THR A 209      -5.835   2.114  10.036  1.00 95.63           N  \\nATOM   1659  CA  THR A 209      -5.224   3.435   9.836  1.00 95.63           C  \\nATOM   1660  C   THR A 209      -6.267   4.555   9.845  1.00 95.63           C  \\nATOM   1661  CB  THR A 209      -4.410   3.442   8.533  1.00 95.63           C  \\nATOM   1662  O   THR A 209      -6.071   5.545  10.551  1.00 95.63           O  \\nATOM   1663  CG2 THR A 209      -3.883   4.817   8.133  1.00 95.63           C  \\nATOM   1664  OG1 THR A 209      -3.279   2.627   8.714  1.00 95.63           O  \\nATOM   1665  N   MET A 210      -7.393   4.388   9.141  1.00 96.29           N  \\nATOM   1666  CA  MET A 210      -8.489   5.364   9.138  1.00 96.29           C  \\nATOM   1667  C   MET A 210      -9.025   5.604  10.549  1.00 96.29           C  \\nATOM   1668  CB  MET A 210      -9.639   4.874   8.248  1.00 96.29           C  \\nATOM   1669  O   MET A 210      -9.120   6.746  10.981  1.00 96.29           O  \\nATOM   1670  CG  MET A 210     -10.691   5.962   8.009  1.00 96.29           C  \\nATOM   1671  SD  MET A 210     -12.088   5.395   7.004  1.00 96.29           S  \\nATOM   1672  CE  MET A 210     -12.898   4.309   8.207  1.00 96.29           C  \\nATOM   1673  N   ILE A 211      -9.336   4.535  11.287  1.00 93.69           N  \\nATOM   1674  CA  ILE A 211      -9.911   4.624  12.634  1.00 93.69           C  \\nATOM   1675  C   ILE A 211      -8.920   5.234  13.630  1.00 93.69           C  \\nATOM   1676  CB  ILE A 211     -10.402   3.229  13.081  1.00 93.69           C  \\nATOM   1677  O   ILE A 211      -9.310   6.035  14.480  1.00 93.69           O  \\nATOM   1678  CG1 ILE A 211     -11.576   2.724  12.207  1.00 93.69           C  \\nATOM   1679  CG2 ILE A 211     -10.792   3.227  14.569  1.00 93.69           C  \\nATOM   1680  CD1 ILE A 211     -12.879   3.523  12.312  1.00 93.69           C  \\nATOM   1681  N   SER A 212      -7.635   4.899  13.513  1.00 91.80           N  \\nATOM   1682  CA  SER A 212      -6.592   5.497  14.346  1.00 91.80           C  \\nATOM   1683  C   SER A 212      -6.480   7.005  14.122  1.00 91.80           C  \\nATOM   1684  CB  SER A 212      -5.247   4.834  14.064  1.00 91.80           C  \\nATOM   1685  O   SER A 212      -6.331   7.746  15.088  1.00 91.80           O  \\nATOM   1686  OG  SER A 212      -4.287   5.309  14.989  1.00 91.80           O  \\nATOM   1687  N   CYS A 213      -6.554   7.462  12.871  1.00 92.71           N  \\nATOM   1688  CA  CYS A 213      -6.515   8.886  12.544  1.00 92.71           C  \\nATOM   1689  C   CYS A 213      -7.844   9.593  12.852  1.00 92.71           C  \\nATOM   1690  CB  CYS A 213      -6.111   9.039  11.075  1.00 92.71           C  \\nATOM   1691  O   CYS A 213      -7.823  10.747  13.265  1.00 92.71           O  \\nATOM   1692  SG  CYS A 213      -4.368   8.571  10.858  1.00 92.71           S  \\nATOM   1693  N   TYR A 214      -8.984   8.903  12.738  1.00 91.52           N  \\nATOM   1694  CA  TYR A 214     -10.296   9.438  13.117  1.00 91.52           C  \\nATOM   1695  C   TYR A 214     -10.348   9.866  14.579  1.00 91.52           C  \\nATOM   1696  CB  TYR A 214     -11.397   8.416  12.826  1.00 91.52           C  \\nATOM   1697  O   TYR A 214     -10.935  10.888  14.919  1.00 91.52           O  \\nATOM   1698  CG  TYR A 214     -12.776   8.993  13.070  1.00 91.52           C  \\nATOM   1699  CD1 TYR A 214     -13.323   9.026  14.368  1.00 91.52           C  \\nATOM   1700  CD2 TYR A 214     -13.480   9.575  12.003  1.00 91.52           C  \\nATOM   1701  CE1 TYR A 214     -14.580   9.618  14.589  1.00 91.52           C  \\nATOM   1702  CE2 TYR A 214     -14.741  10.154  12.211  1.00 91.52           C  \\nATOM   1703  OH  TYR A 214     -16.521  10.711  13.698  1.00 91.52           O  \\nATOM   1704  CZ  TYR A 214     -15.288  10.182  13.507  1.00 91.52           C  \\nATOM   1705  N   TYR A 215      -9.690   9.098  15.445  1.00 84.36           N  \\nATOM   1706  CA  TYR A 215      -9.577   9.437  16.856  1.00 84.36           C  \\nATOM   1707  C   TYR A 215      -8.896  10.807  17.087  1.00 84.36           C  \\nATOM   1708  CB  TYR A 215      -8.839   8.276  17.534  1.00 84.36           C  \\nATOM   1709  O   TYR A 215      -9.186  11.479  18.074  1.00 84.36           O  \\nATOM   1710  CG  TYR A 215      -8.569   8.523  18.993  1.00 84.36           C  \\nATOM   1711  CD1 TYR A 215      -7.447   9.291  19.338  1.00 84.36           C  \\nATOM   1712  CD2 TYR A 215      -9.486   8.111  19.977  1.00 84.36           C  \\nATOM   1713  CE1 TYR A 215      -7.229   9.670  20.667  1.00 84.36           C  \\nATOM   1714  CE2 TYR A 215      -9.281   8.499  21.314  1.00 84.36           C  \\nATOM   1715  OH  TYR A 215      -7.958   9.759  22.895  1.00 84.36           O  \\nATOM   1716  CZ  TYR A 215      -8.160   9.296  21.645  1.00 84.36           C  \\nATOM   1717  N   GLU A 216      -7.998  11.232  16.195  1.00 84.88           N  \\nATOM   1718  CA  GLU A 216      -7.307  12.530  16.270  1.00 84.88           C  \\nATOM   1719  C   GLU A 216      -8.062  13.633  15.520  1.00 84.88           C  \\nATOM   1720  CB  GLU A 216      -5.880  12.380  15.718  1.00 84.88           C  \\nATOM   1721  O   GLU A 216      -8.081  14.783  15.957  1.00 84.88           O  \\nATOM   1722  CG  GLU A 216      -5.049  11.438  16.602  1.00 84.88           C  \\nATOM   1723  CD  GLU A 216      -3.659  11.110  16.050  1.00 84.88           C  \\nATOM   1724  OE1 GLU A 216      -3.081  10.145  16.615  1.00 84.88           O  \\nATOM   1725  OE2 GLU A 216      -3.194  11.785  15.106  1.00 84.88           O  \\nATOM   1726  N   ASP A 217      -8.716  13.280  14.415  1.00 90.56           N  \\nATOM   1727  CA  ASP A 217      -9.524  14.179  13.602  1.00 90.56           C  \\nATOM   1728  C   ASP A 217     -10.779  13.465  13.089  1.00 90.56           C  \\nATOM   1729  CB  ASP A 217      -8.671  14.713  12.445  1.00 90.56           C  \\nATOM   1730  O   ASP A 217     -10.717  12.606  12.209  1.00 90.56           O  \\nATOM   1731  CG  ASP A 217      -9.414  15.716  11.561  1.00 90.56           C  \\nATOM   1732  OD1 ASP A 217     -10.615  15.981  11.804  1.00 90.56           O  \\nATOM   1733  OD2 ASP A 217      -8.775  16.203  10.603  1.00 90.56           O  \\nATOM   1734  N   HIS A 218     -11.944  13.891  13.580  1.00 90.50           N  \\nATOM   1735  CA  HIS A 218     -13.245  13.313  13.236  1.00 90.50           C  \\nATOM   1736  C   HIS A 218     -13.663  13.566  11.773  1.00 90.50           C  \\nATOM   1737  CB  HIS A 218     -14.308  13.845  14.211  1.00 90.50           C  \\nATOM   1738  O   HIS A 218     -14.726  13.113  11.352  1.00 90.50           O  \\nATOM   1739  CG  HIS A 218     -14.121  13.401  15.641  1.00 90.50           C  \\nATOM   1740  CD2 HIS A 218     -14.893  12.492  16.313  1.00 90.50           C  \\nATOM   1741  ND1 HIS A 218     -13.159  13.839  16.527  1.00 90.50           N  \\nATOM   1742  CE1 HIS A 218     -13.342  13.196  17.691  1.00 90.50           C  \\nATOM   1743  NE2 HIS A 218     -14.401  12.380  17.615  1.00 90.50           N  \\nATOM   1744  N   GLN A 219     -12.867  14.302  10.991  1.00 93.33           N  \\nATOM   1745  CA  GLN A 219     -13.011  14.418   9.535  1.00 93.33           C  \\nATOM   1746  C   GLN A 219     -12.255  13.313   8.771  1.00 93.33           C  \\nATOM   1747  CB  GLN A 219     -12.543  15.812   9.082  1.00 93.33           C  \\nATOM   1748  O   GLN A 219     -12.288  13.290   7.539  1.00 93.33           O  \\nATOM   1749  CG  GLN A 219     -13.286  16.979   9.748  1.00 93.33           C  \\nATOM   1750  CD  GLN A 219     -14.760  17.025   9.367  1.00 93.33           C  \\nATOM   1751  NE2 GLN A 219     -15.656  16.532  10.192  1.00 93.33           N  \\nATOM   1752  OE1 GLN A 219     -15.139  17.517   8.321  1.00 93.33           O  \\nATOM   1753  N   CYS A 220     -11.541  12.413   9.462  1.00 95.56           N  \\nATOM   1754  CA  CYS A 220     -10.745  11.366   8.825  1.00 95.56           C  \\nATOM   1755  C   CYS A 220     -11.609  10.201   8.335  1.00 95.56           C  \\nATOM   1756  CB  CYS A 220      -9.612  10.912   9.743  1.00 95.56           C  \\nATOM   1757  O   CYS A 220     -11.838   9.225   9.044  1.00 95.56           O  \\nATOM   1758  SG  CYS A 220      -8.577   9.726   8.840  1.00 95.56           S  \\nATOM   1759  N   GLU A 221     -12.046  10.283   7.085  1.00 96.16           N  \\nATOM   1760  CA  GLU A 221     -12.952   9.303   6.478  1.00 96.16           C  \\nATOM   1761  C   GLU A 221     -12.312   8.494   5.347  1.00 96.16           C  \\nATOM   1762  CB  GLU A 221     -14.236  10.005   6.041  1.00 96.16           C  \\nATOM   1763  O   GLU A 221     -13.010   7.766   4.641  1.00 96.16           O  \\nATOM   1764  CG  GLU A 221     -15.003  10.589   7.239  1.00 96.16           C  \\nATOM   1765  CD  GLU A 221     -16.401  11.044   6.825  1.00 96.16           C  \\nATOM   1766  OE1 GLU A 221     -17.332  11.017   7.664  1.00 96.16           O  \\nATOM   1767  OE2 GLU A 221     -16.582  11.339   5.625  1.00 96.16           O  \\nATOM   1768  N   VAL A 222     -10.988   8.598   5.191  1.00 98.08           N  \\nATOM   1769  CA  VAL A 222     -10.179   7.778   4.282  1.00 98.08           C  \\nATOM   1770  C   VAL A 222      -8.957   7.254   5.028  1.00 98.08           C  \\nATOM   1771  CB  VAL A 222      -9.741   8.570   3.036  1.00 98.08           C  \\nATOM   1772  O   VAL A 222      -8.245   8.020   5.680  1.00 98.08           O  \\nATOM   1773  CG1 VAL A 222      -8.985   7.695   2.027  1.00 98.08           C  \\nATOM   1774  CG2 VAL A 222     -10.920   9.198   2.289  1.00 98.08           C  \\nATOM   1775  N   GLY A 223      -8.691   5.956   4.904  1.00 97.90           N  \\nATOM   1776  CA  GLY A 223      -7.450   5.327   5.349  1.00 97.90           C  \\nATOM   1777  C   GLY A 223      -6.646   4.835   4.160  1.00 97.90           C  \\nATOM   1778  O   GLY A 223      -7.185   4.162   3.286  1.00 97.90           O  \\nATOM   1779  N   MET A 224      -5.355   5.148   4.120  1.00 97.88           N  \\nATOM   1780  CA  MET A 224      -4.455   4.743   3.047  1.00 97.88           C  \\nATOM   1781  C   MET A 224      -3.206   4.066   3.583  1.00 97.88           C  \\nATOM   1782  CB  MET A 224      -4.024   5.946   2.210  1.00 97.88           C  \\nATOM   1783  O   MET A 224      -2.588   4.532   4.539  1.00 97.88           O  \\nATOM   1784  CG  MET A 224      -5.168   6.554   1.405  1.00 97.88           C  \\nATOM   1785  SD  MET A 224      -4.592   7.772   0.198  1.00 97.88           S  \\nATOM   1786  CE  MET A 224      -3.627   6.723  -0.910  1.00 97.88           C  \\nATOM   1787  N   ILE A 225      -2.779   3.027   2.874  1.00 96.64           N  \\nATOM   1788  CA  ILE A 225      -1.469   2.412   3.048  1.00 96.64           C  \\nATOM   1789  C   ILE A 225      -0.663   2.655   1.778  1.00 96.64           C  \\nATOM   1790  CB  ILE A 225      -1.604   0.915   3.384  1.00 96.64           C  \\nATOM   1791  O   ILE A 225      -1.080   2.260   0.692  1.00 96.64           O  \\nATOM   1792  CG1 ILE A 225      -2.465   0.671   4.641  1.00 96.64           C  \\nATOM   1793  CG2 ILE A 225      -0.216   0.266   3.543  1.00 96.64           C  \\nATOM   1794  CD1 ILE A 225      -1.953   1.277   5.950  1.00 96.64           C  \\nATOM   1795  N   VAL A 226       0.503   3.285   1.910  1.00 97.26           N  \\nATOM   1796  CA  VAL A 226       1.485   3.474   0.834  1.00 97.26           C  \\nATOM   1797  C   VAL A 226       2.853   3.040   1.363  1.00 97.26           C  \\nATOM   1798  CB  VAL A 226       1.483   4.918   0.303  1.00 97.26           C  \\nATOM   1799  O   VAL A 226       3.667   3.832   1.845  1.00 97.26           O  \\nATOM   1800  CG1 VAL A 226       2.283   4.996  -1.001  1.00 97.26           C  \\nATOM   1801  CG2 VAL A 226       0.083   5.479   0.020  1.00 97.26           C  \\nATOM   1802  N   GLY A 227       3.075   1.728   1.356  1.00 94.28           N  \\nATOM   1803  CA  GLY A 227       4.227   1.063   1.964  1.00 94.28           C  \\nATOM   1804  C   GLY A 227       4.749  -0.043   1.063  1.00 94.28           C  \\nATOM   1805  O   GLY A 227       5.016   0.200  -0.107  1.00 94.28           O  \\nATOM   1806  N   THR A 228       4.883  -1.266   1.586  1.00 91.11           N  \\nATOM   1807  CA  THR A 228       5.219  -2.451   0.773  1.00 91.11           C  \\nATOM   1808  C   THR A 228       4.225  -2.634  -0.380  1.00 91.11           C  \\nATOM   1809  CB  THR A 228       5.240  -3.711   1.657  1.00 91.11           C  \\nATOM   1810  O   THR A 228       4.643  -2.866  -1.511  1.00 91.11           O  \\nATOM   1811  CG2 THR A 228       5.673  -4.979   0.928  1.00 91.11           C  \\nATOM   1812  OG1 THR A 228       6.155  -3.512   2.709  1.00 91.11           O  \\nATOM   1813  N   GLY A 229       2.934  -2.474  -0.085  1.00 93.07           N  \\nATOM   1814  CA  GLY A 229       1.842  -2.415  -1.056  1.00 93.07           C  \\nATOM   1815  C   GLY A 229       1.159  -1.046  -1.071  1.00 93.07           C  \\nATOM   1816  O   GLY A 229       1.620  -0.115  -0.401  1.00 93.07           O  \\nATOM   1817  N   CYS A 230       0.052  -0.933  -1.804  1.00 95.59           N  \\nATOM   1818  CA  CYS A 230      -0.761   0.279  -1.845  1.00 95.59           C  \\nATOM   1819  C   CYS A 230      -2.255  -0.053  -1.846  1.00 95.59           C  \\nATOM   1820  CB  CYS A 230      -0.364   1.150  -3.043  1.00 95.59           C  \\nATOM   1821  O   CYS A 230      -2.741  -0.684  -2.779  1.00 95.59           O  \\nATOM   1822  SG  CYS A 230      -1.239   2.739  -2.931  1.00 95.59           S  \\nATOM   1823  N   ASN A 231      -2.984   0.405  -0.827  1.00 97.28           N  \\nATOM   1824  CA  ASN A 231      -4.427   0.193  -0.698  1.00 97.28           C  \\nATOM   1825  C   ASN A 231      -5.110   1.403  -0.035  1.00 97.28           C  \\nATOM   1826  CB  ASN A 231      -4.701  -1.132   0.034  1.00 97.28           C  \\nATOM   1827  O   ASN A 231      -4.439   2.213   0.616  1.00 97.28           O  \\nATOM   1828  CG  ASN A 231      -6.149  -1.574  -0.121  1.00 97.28           C  \\nATOM   1829  ND2 ASN A 231      -6.643  -2.362   0.796  1.00 97.28           N  \\nATOM   1830  OD1 ASN A 231      -6.848  -1.176  -1.043  1.00 97.28           O  \\nATOM   1831  N   ALA A 232      -6.430   1.510  -0.174  1.00 98.35           N  \\nATOM   1832  CA  ALA A 232      -7.242   2.478   0.549  1.00 98.35           C  \\nATOM   1833  C   ALA A 232      -8.595   1.910   0.992  1.00 98.35           C  \\nATOM   1834  CB  ALA A 232      -7.432   3.728  -0.313  1.00 98.35           C  \\nATOM   1835  O   ALA A 232      -9.159   1.021   0.356  1.00 98.35           O  \\nATOM   1836  N   CYS A 233      -9.145   2.496   2.048  1.00 98.12           N  \\nATOM   1837  CA  CYS A 233     -10.540   2.367   2.446  1.00 98.12           C  \\nATOM   1838  C   CYS A 233     -11.151   3.753   2.665  1.00 98.12           C  \\nATOM   1839  CB  CYS A 233     -10.651   1.506   3.711  1.00 98.12           C  \\nATOM   1840  O   CYS A 233     -10.427   4.731   2.863  1.00 98.12           O  \\nATOM   1841  SG  CYS A 233     -10.082   2.442   5.159  1.00 98.12           S  \\nATOM   1842  N   TYR A 234     -12.476   3.836   2.691  1.00 98.06           N  \\nATOM   1843  CA  TYR A 234     -13.186   5.069   3.034  1.00 98.06           C  \\nATOM   1844  C   TYR A 234     -14.588   4.784   3.578  1.00 98.06           C  \\nATOM   1845  CB  TYR A 234     -13.247   5.999   1.812  1.00 98.06           C  \\nATOM   1846  O   TYR A 234     -15.077   3.659   3.474  1.00 98.06           O  \\nATOM   1847  CG  TYR A 234     -14.151   5.509   0.703  1.00 98.06           C  \\nATOM   1848  CD1 TYR A 234     -13.730   4.458  -0.131  1.00 98.06           C  \\nATOM   1849  CD2 TYR A 234     -15.424   6.082   0.528  1.00 98.06           C  \\nATOM   1850  CE1 TYR A 234     -14.593   3.967  -1.123  1.00 98.06           C  \\nATOM   1851  CE2 TYR A 234     -16.279   5.613  -0.484  1.00 98.06           C  \\nATOM   1852  OH  TYR A 234     -16.693   4.055  -2.257  1.00 98.06           O  \\nATOM   1853  CZ  TYR A 234     -15.867   4.542  -1.302  1.00 98.06           C  \\nATOM   1854  N   MET A 235     -15.232   5.789   4.175  1.00 96.17           N  \\nATOM   1855  CA  MET A 235     -16.636   5.710   4.598  1.00 96.17           C  \\nATOM   1856  C   MET A 235     -17.583   5.975   3.419  1.00 96.17           C  \\nATOM   1857  CB  MET A 235     -16.906   6.698   5.743  1.00 96.17           C  \\nATOM   1858  O   MET A 235     -17.682   7.110   2.948  1.00 96.17           O  \\nATOM   1859  CG  MET A 235     -16.178   6.334   7.043  1.00 96.17           C  \\nATOM   1860  SD  MET A 235     -16.573   4.712   7.770  1.00 96.17           S  \\nATOM   1861  CE  MET A 235     -18.368   4.828   7.984  1.00 96.17           C  \\nATOM   1862  N   GLU A 236     -18.297   4.940   2.980  1.00 96.33           N  \\nATOM   1863  CA  GLU A 236     -19.298   4.995   1.907  1.00 96.33           C  \\nATOM   1864  C   GLU A 236     -20.724   5.034   2.481  1.00 96.33           C  \\nATOM   1865  CB  GLU A 236     -19.079   3.796   0.963  1.00 96.33           C  \\nATOM   1866  O   GLU A 236     -20.992   4.499   3.563  1.00 96.33           O  \\nATOM   1867  CG  GLU A 236     -19.969   3.743  -0.291  1.00 96.33           C  \\nATOM   1868  CD  GLU A 236     -19.869   4.986  -1.189  1.00 96.33           C  \\nATOM   1869  OE1 GLU A 236     -20.601   5.970  -0.937  1.00 96.33           O  \\nATOM   1870  OE2 GLU A 236     -19.076   4.962  -2.163  1.00 96.33           O  \\nATOM   1871  N   GLU A 237     -21.640   5.665   1.746  1.00 95.22           N  \\nATOM   1872  CA  GLU A 237     -23.070   5.679   2.067  1.00 95.22           C  \\nATOM   1873  C   GLU A 237     -23.685   4.302   1.782  1.00 95.22           C  \\nATOM   1874  CB  GLU A 237     -23.800   6.773   1.269  1.00 95.22           C  \\nATOM   1875  O   GLU A 237     -23.511   3.756   0.692  1.00 95.22           O  \\nATOM   1876  CG  GLU A 237     -23.233   8.195   1.431  1.00 95.22           C  \\nATOM   1877  CD  GLU A 237     -23.203   8.685   2.888  1.00 95.22           C  \\nATOM   1878  OE1 GLU A 237     -22.242   9.414   3.243  1.00 95.22           O  \\nATOM   1879  OE2 GLU A 237     -24.106   8.305   3.668  1.00 95.22           O  \\nATOM   1880  N   MET A 238     -24.431   3.734   2.735  1.00 94.83           N  \\nATOM   1881  CA  MET A 238     -24.968   2.368   2.617  1.00 94.83           C  \\nATOM   1882  C   MET A 238     -25.888   2.181   1.407  1.00 94.83           C  \\nATOM   1883  CB  MET A 238     -25.717   1.985   3.898  1.00 94.83           C  \\nATOM   1884  O   MET A 238     -25.868   1.120   0.794  1.00 94.83           O  \\nATOM   1885  CG  MET A 238     -24.775   1.519   5.010  1.00 94.83           C  \\nATOM   1886  SD  MET A 238     -23.848  -0.010   4.697  1.00 94.83           S  \\nATOM   1887  CE  MET A 238     -25.178  -1.162   4.262  1.00 94.83           C  \\nATOM   1888  N   GLN A 239     -26.612   3.225   0.993  1.00 95.01           N  \\nATOM   1889  CA  GLN A 239     -27.411   3.222  -0.239  1.00 95.01           C  \\nATOM   1890  C   GLN A 239     -26.606   2.885  -1.513  1.00 95.01           C  \\nATOM   1891  CB  GLN A 239     -28.106   4.587  -0.390  1.00 95.01           C  \\nATOM   1892  O   GLN A 239     -27.194   2.500  -2.519  1.00 95.01           O  \\nATOM   1893  CG  GLN A 239     -27.111   5.742  -0.602  1.00 95.01           C  \\nATOM   1894  CD  GLN A 239     -27.787   7.080  -0.863  1.00 95.01           C  \\nATOM   1895  NE2 GLN A 239     -27.333   7.815  -1.855  1.00 95.01           N  \\nATOM   1896  OE1 GLN A 239     -28.713   7.502  -0.191  1.00 95.01           O  \\nATOM   1897  N   ASN A 240     -25.277   3.044  -1.486  1.00 95.87           N  \\nATOM   1898  CA  ASN A 240     -24.388   2.727  -2.602  1.00 95.87           C  \\nATOM   1899  C   ASN A 240     -23.775   1.318  -2.492  1.00 95.87           C  \\nATOM   1900  CB  ASN A 240     -23.276   3.792  -2.680  1.00 95.87           C  \\nATOM   1901  O   ASN A 240     -23.098   0.898  -3.424  1.00 95.87           O  \\nATOM   1902  CG  ASN A 240     -23.768   5.212  -2.893  1.00 95.87           C  \\nATOM   1903  ND2 ASN A 240     -23.052   6.188  -2.386  1.00 95.87           N  \\nATOM   1904  OD1 ASN A 240     -24.770   5.487  -3.534  1.00 95.87           O  \\nATOM   1905  N   VAL A 241     -23.950   0.607  -1.370  1.00 95.90           N  \\nATOM   1906  CA  VAL A 241     -23.299  -0.683  -1.084  1.00 95.90           C  \\nATOM   1907  C   VAL A 241     -24.302  -1.825  -1.267  1.00 95.90           C  \\nATOM   1908  CB  VAL A 241     -22.658  -0.701   0.326  1.00 95.90           C  \\nATOM   1909  O   VAL A 241     -24.852  -2.346  -0.303  1.00 95.90           O  \\nATOM   1910  CG1 VAL A 241     -21.804  -1.966   0.527  1.00 95.90           C  \\nATOM   1911  CG2 VAL A 241     -21.739   0.503   0.585  1.00 95.90           C  \\nATOM   1912  N   GLU A 242     -24.513  -2.271  -2.507  1.00 96.47           N  \\nATOM   1913  CA  GLU A 242     -25.487  -3.338  -2.819  1.00 96.47           C  \\nATOM   1914  C   GLU A 242     -25.071  -4.729  -2.298  1.00 96.47           C  \\nATOM   1915  CB  GLU A 242     -25.709  -3.423  -4.335  1.00 96.47           C  \\nATOM   1916  O   GLU A 242     -25.857  -5.674  -2.317  1.00 96.47           O  \\nATOM   1917  CG  GLU A 242     -26.308  -2.156  -4.969  1.00 96.47           C  \\nATOM   1918  CD  GLU A 242     -26.504  -2.300  -6.490  1.00 96.47           C  \\nATOM   1919  OE1 GLU A 242     -26.937  -1.310  -7.124  1.00 96.47           O  \\nATOM   1920  OE2 GLU A 242     -26.171  -3.379  -7.043  1.00 96.47           O  \\nATOM   1921  N   LEU A 243     -23.824  -4.869  -1.838  1.00 93.58           N  \\nATOM   1922  CA  LEU A 243     -23.253  -6.121  -1.331  1.00 93.58           C  \\nATOM   1923  C   LEU A 243     -23.720  -6.488   0.084  1.00 93.58           C  \\nATOM   1924  CB  LEU A 243     -21.722  -6.002  -1.341  1.00 93.58           C  \\nATOM   1925  O   LEU A 243     -23.450  -7.597   0.547  1.00 93.58           O  \\nATOM   1926  CG  LEU A 243     -21.099  -5.677  -2.705  1.00 93.58           C  \\nATOM   1927  CD1 LEU A 243     -19.595  -5.517  -2.512  1.00 93.58           C  \\nATOM   1928  CD2 LEU A 243     -21.372  -6.768  -3.741  1.00 93.58           C  \\nATOM   1929  N   VAL A 244     -24.358  -5.557   0.795  1.00 92.30           N  \\nATOM   1930  CA  VAL A 244     -24.839  -5.748   2.166  1.00 92.30           C  \\nATOM   1931  C   VAL A 244     -26.299  -5.324   2.235  1.00 92.30           C  \\nATOM   1932  CB  VAL A 244     -23.983  -4.964   3.179  1.00 92.30           C  \\nATOM   1933  O   VAL A 244     -26.692  -4.325   1.646  1.00 92.30           O  \\nATOM   1934  CG1 VAL A 244     -24.454  -5.193   4.623  1.00 92.30           C  \\nATOM   1935  CG2 VAL A 244     -22.508  -5.382   3.119  1.00 92.30           C  \\nATOM   1936  N   GLU A 245     -27.113  -6.071   2.979  1.00 91.11           N  \\nATOM   1937  CA  GLU A 245     -28.515  -5.709   3.176  1.00 91.11           C  \\nATOM   1938  C   GLU A 245     -28.671  -4.416   4.002  1.00 91.11           C  \\nATOM   1939  CB  GLU A 245     -29.300  -6.868   3.812  1.00 91.11           C  \\nATOM   1940  O   GLU A 245     -28.004  -4.203   5.026  1.00 91.11           O  \\nATOM   1941  CG  GLU A 245     -29.395  -8.107   2.901  1.00 91.11           C  \\nATOM   1942  CD  GLU A 245     -30.291  -9.222   3.476  1.00 91.11           C  \\nATOM   1943  OE1 GLU A 245     -30.542 -10.202   2.737  1.00 91.11           O  \\nATOM   1944  OE2 GLU A 245     -30.728  -9.105   4.645  1.00 91.11           O  \\nATOM   1945  N   GLY A 246     -29.621  -3.583   3.568  1.00 91.34           N  \\nATOM   1946  CA  GLY A 246     -29.977  -2.304   4.185  1.00 91.34           C  \\nATOM   1947  C   GLY A 246     -29.236  -1.106   3.587  1.00 91.34           C  \\nATOM   1948  O   GLY A 246     -28.090  -1.208   3.172  1.00 91.34           O  \\nATOM   1949  N   ASP A 247     -29.897   0.047   3.583  1.00 91.55           N  \\nATOM   1950  CA  ASP A 247     -29.433   1.309   2.991  1.00 91.55           C  \\nATOM   1951  C   ASP A 247     -29.157   2.407   4.038  1.00 91.55           C  \\nATOM   1952  CB  ASP A 247     -30.459   1.764   1.936  1.00 91.55           C  \\nATOM   1953  O   ASP A 247     -28.713   3.503   3.696  1.00 91.55           O  \\nATOM   1954  CG  ASP A 247     -31.891   1.961   2.465  1.00 91.55           C  \\nATOM   1955  OD1 ASP A 247     -32.155   1.604   3.639  1.00 91.55           O  \\nATOM   1956  OD2 ASP A 247     -32.740   2.406   1.662  1.00 91.55           O  \\nATOM   1957  N   GLU A 248     -29.372   2.116   5.325  1.00 91.74           N  \\nATOM   1958  CA  GLU A 248     -29.239   3.094   6.405  1.00 91.74           C  \\nATOM   1959  C   GLU A 248     -27.797   3.289   6.895  1.00 91.74           C  \\nATOM   1960  CB  GLU A 248     -30.131   2.738   7.602  1.00 91.74           C  \\nATOM   1961  O   GLU A 248     -27.109   2.355   7.329  1.00 91.74           O  \\nATOM   1962  CG  GLU A 248     -31.636   2.827   7.303  1.00 91.74           C  \\nATOM   1963  CD  GLU A 248     -32.502   2.697   8.570  1.00 91.74           C  \\nATOM   1964  OE1 GLU A 248     -33.730   2.924   8.469  1.00 91.74           O  \\nATOM   1965  OE2 GLU A 248     -31.945   2.396   9.654  1.00 91.74           O  \\nATOM   1966  N   GLY A 249     -27.385   4.556   6.945  1.00 92.95           N  \\nATOM   1967  CA  GLY A 249     -26.119   4.985   7.525  1.00 92.95           C  \\nATOM   1968  C   GLY A 249     -24.937   4.790   6.581  1.00 92.95           C  \\nATOM   1969  O   GLY A 249     -25.057   4.897   5.364  1.00 92.95           O  \\nATOM   1970  N   ARG A 250     -23.762   4.542   7.163  1.00 93.49           N  \\nATOM   1971  CA  ARG A 250     -22.491   4.471   6.435  1.00 93.49           C  \\nATOM   1972  C   ARG A 250     -21.715   3.228   6.832  1.00 93.49           C  \\nATOM   1973  CB  ARG A 250     -21.678   5.759   6.655  1.00 93.49           C  \\nATOM   1974  O   ARG A 250     -21.830   2.748   7.962  1.00 93.49           O  \\nATOM   1975  CG  ARG A 250     -22.411   6.992   6.098  1.00 93.49           C  \\nATOM   1976  CD  ARG A 250     -21.650   8.301   6.306  1.00 93.49           C  \\nATOM   1977  NE  ARG A 250     -21.483   8.639   7.739  1.00 93.49           N  \\nATOM   1978  NH1 ARG A 250     -19.907  10.250   7.401  1.00 93.49           N  \\nATOM   1979  NH2 ARG A 250     -20.436   9.685   9.486  1.00 93.49           N  \\nATOM   1980  CZ  ARG A 250     -20.619   9.522   8.207  1.00 93.49           C  \\nATOM   1981  N   MET A 251     -20.891   2.732   5.921  1.00 94.49           N  \\nATOM   1982  CA  MET A 251     -19.983   1.622   6.183  1.00 94.49           C  \\nATOM   1983  C   MET A 251     -18.611   1.921   5.598  1.00 94.49           C  \\nATOM   1984  CB  MET A 251     -20.580   0.315   5.644  1.00 94.49           C  \\nATOM   1985  O   MET A 251     -18.487   2.467   4.505  1.00 94.49           O  \\nATOM   1986  CG  MET A 251     -19.678  -0.891   5.927  1.00 94.49           C  \\nATOM   1987  SD  MET A 251     -20.291  -2.505   5.388  1.00 94.49           S  \\nATOM   1988  CE  MET A 251     -21.765  -2.695   6.410  1.00 94.49           C  \\nATOM   1989  N   CYS A 252     -17.566   1.542   6.329  1.00 95.98           N  \\nATOM   1990  CA  CYS A 252     -16.228   1.557   5.773  1.00 95.98           C  \\nATOM   1991  C   CYS A 252     -16.102   0.474   4.694  1.00 95.98           C  \\nATOM   1992  CB  CYS A 252     -15.199   1.412   6.892  1.00 95.98           C  \\nATOM   1993  O   CYS A 252     -16.375  -0.706   4.940  1.00 95.98           O  \\nATOM   1994  SG  CYS A 252     -13.547   1.624   6.181  1.00 95.98           S  \\nATOM   1995  N   VAL A 253     -15.669   0.875   3.506  1.00 97.54           N  \\nATOM   1996  CA  VAL A 253     -15.423  -0.009   2.371  1.00 97.54           C  \\nATOM   1997  C   VAL A 253     -13.928  -0.042   2.100  1.00 97.54           C  \\nATOM   1998  CB  VAL A 253     -16.227   0.445   1.142  1.00 97.54           C  \\nATOM   1999  O   VAL A 253     -13.291   1.000   1.945  1.00 97.54           O  \\nATOM   2000  CG1 VAL A 253     -15.889  -0.419  -0.074  1.00 97.54           C  \\nATOM   2001  CG2 VAL A 253     -17.732   0.309   1.410  1.00 97.54           C  \\nATOM   2002  N   ASN A 254     -13.367  -1.245   2.043  1.00 97.72           N  \\nATOM   2003  CA  ASN A 254     -11.996  -1.473   1.616  1.00 97.72           C  \\nATOM   2004  C   ASN A 254     -11.971  -1.602   0.090  1.00 97.72           C  \\nATOM   2005  CB  ASN A 254     -11.473  -2.717   2.342  1.00 97.72           C  \\nATOM   2006  O   ASN A 254     -12.585  -2.506  -0.470  1.00 97.72           O  \\nATOM   2007  CG  ASN A 254     -10.074  -3.102   1.914  1.00 97.72           C  \\nATOM   2008  ND2 ASN A 254      -9.595  -4.198   2.439  1.00 97.72           N  \\nATOM   2009  OD1 ASN A 254      -9.419  -2.448   1.117  1.00 97.72           O  \\nATOM   2010  N   THR A 255     -11.278  -0.697  -0.595  1.00 98.21           N  \\nATOM   2011  CA  THR A 255     -11.315  -0.648  -2.062  1.00 98.21           C  \\nATOM   2012  C   THR A 255     -10.654  -1.868  -2.701  1.00 98.21           C  \\nATOM   2013  CB  THR A 255     -10.670   0.634  -2.611  1.00 98.21           C  \\nATOM   2014  O   THR A 255     -11.110  -2.319  -3.752  1.00 98.21           O  \\nATOM   2015  CG2 THR A 255     -11.329   1.906  -2.072  1.00 98.21           C  \\nATOM   2016  OG1 THR A 255      -9.298   0.695  -2.295  1.00 98.21           O  \\nATOM   2017  N   GLU A 256      -9.601  -2.405  -2.072  1.00 96.76           N  \\nATOM   2018  CA  GLU A 256      -8.670  -3.360  -2.688  1.00 96.76           C  \\nATOM   2019  C   GLU A 256      -8.231  -2.903  -4.091  1.00 96.76           C  \\nATOM   2020  CB  GLU A 256      -9.217  -4.798  -2.634  1.00 96.76           C  \\nATOM   2021  O   GLU A 256      -8.126  -3.687  -5.035  1.00 96.76           O  \\nATOM   2022  CG  GLU A 256      -9.296  -5.369  -1.209  1.00 96.76           C  \\nATOM   2023  CD  GLU A 256      -7.940  -5.459  -0.484  1.00 96.76           C  \\nATOM   2024  OE1 GLU A 256      -7.940  -5.511   0.769  1.00 96.76           O  \\nATOM   2025  OE2 GLU A 256      -6.891  -5.515  -1.160  1.00 96.76           O  \\nATOM   2026  N   TRP A 257      -7.966  -1.599  -4.243  1.00 97.81           N  \\nATOM   2027  CA  TRP A 257      -7.658  -0.981  -5.536  1.00 97.81           C  \\nATOM   2028  C   TRP A 257      -6.321  -1.426  -6.142  1.00 97.81           C  \\nATOM   2029  CB  TRP A 257      -7.731   0.544  -5.403  1.00 97.81           C  \\nATOM   2030  O   TRP A 257      -5.963  -0.993  -7.234  1.00 97.81           O  \\nATOM   2031  CG  TRP A 257      -6.690   1.240  -4.568  1.00 97.81           C  \\nATOM   2032  CD1 TRP A 257      -5.538   0.722  -4.075  1.00 97.81           C  \\nATOM   2033  CD2 TRP A 257      -6.690   2.632  -4.131  1.00 97.81           C  \\nATOM   2034  CE2 TRP A 257      -5.485   2.880  -3.410  1.00 97.81           C  \\nATOM   2035  CE3 TRP A 257      -7.573   3.721  -4.278  1.00 97.81           C  \\nATOM   2036  NE1 TRP A 257      -4.802   1.699  -3.456  1.00 97.81           N  \\nATOM   2037  CH2 TRP A 257      -6.069   5.181  -3.014  1.00 97.81           C  \\nATOM   2038  CZ2 TRP A 257      -5.161   4.121  -2.866  1.00 97.81           C  \\nATOM   2039  CZ3 TRP A 257      -7.265   4.977  -3.721  1.00 97.81           C  \\nATOM   2040  N   GLY A 258      -5.555  -2.270  -5.441  1.00 96.80           N  \\nATOM   2041  CA  GLY A 258      -4.263  -2.761  -5.907  1.00 96.80           C  \\nATOM   2042  C   GLY A 258      -4.404  -3.567  -7.197  1.00 96.80           C  \\nATOM   2043  O   GLY A 258      -3.517  -3.498  -8.046  1.00 96.80           O  \\nATOM   2044  N   ALA A 259      -5.551  -4.235  -7.369  1.00 96.71           N  \\nATOM   2045  CA  ALA A 259      -5.952  -4.993  -8.555  1.00 96.71           C  \\nATOM   2046  C   ALA A 259      -6.477  -4.122  -9.712  1.00 96.71           C  \\nATOM   2047  CB  ALA A 259      -6.992  -6.021  -8.097  1.00 96.71           C  \\nATOM   2048  O   ALA A 259      -6.822  -4.633 -10.775  1.00 96.71           O  \\nATOM   2049  N   PHE A 260      -6.553  -2.798  -9.549  1.00 98.45           N  \\nATOM   2050  CA  PHE A 260      -6.910  -1.921 -10.658  1.00 98.45           C  \\nATOM   2051  C   PHE A 260      -5.923  -2.093 -11.826  1.00 98.45           C  \\nATOM   2052  CB  PHE A 260      -6.998  -0.480 -10.157  1.00 98.45           C  \\nATOM   2053  O   PHE A 260      -4.708  -2.102 -11.634  1.00 98.45           O  \\nATOM   2054  CG  PHE A 260      -7.327   0.533 -11.226  1.00 98.45           C  \\nATOM   2055  CD1 PHE A 260      -6.460   1.617 -11.433  1.00 98.45           C  \\nATOM   2056  CD2 PHE A 260      -8.499   0.415 -11.996  1.00 98.45           C  \\nATOM   2057  CE1 PHE A 260      -6.770   2.582 -12.398  1.00 98.45           C  \\nATOM   2058  CE2 PHE A 260      -8.793   1.371 -12.981  1.00 98.45           C  \\nATOM   2059  CZ  PHE A 260      -7.920   2.451 -13.188  1.00 98.45           C  \\nATOM   2060  N   GLY A 261      -6.442  -2.251 -13.043  1.00 97.78           N  \\nATOM   2061  CA  GLY A 261      -5.640  -2.551 -14.229  1.00 97.78           C  \\nATOM   2062  C   GLY A 261      -5.601  -4.029 -14.606  1.00 97.78           C  \\nATOM   2063  O   GLY A 261      -5.274  -4.316 -15.756  1.00 97.78           O  \\nATOM   2064  N   ASP A 262      -5.965  -4.950 -13.705  1.00 96.60           N  \\nATOM   2065  CA  ASP A 262      -5.951  -6.397 -13.967  1.00 96.60           C  \\nATOM   2066  C   ASP A 262      -6.902  -6.796 -15.121  1.00 96.60           C  \\nATOM   2067  CB  ASP A 262      -6.297  -7.176 -12.676  1.00 96.60           C  \\nATOM   2068  O   ASP A 262      -6.708  -7.839 -15.744  1.00 96.60           O  \\nATOM   2069  CG  ASP A 262      -5.263  -7.084 -11.532  1.00 96.60           C  \\nATOM   2070  OD1 ASP A 262      -4.224  -6.389 -11.650  1.00 96.60           O  \\nATOM   2071  OD2 ASP A 262      -5.468  -7.737 -10.479  1.00 96.60           O  \\nATOM   2072  N   SER A 263      -7.896  -5.957 -15.459  1.00 96.14           N  \\nATOM   2073  CA  SER A 263      -8.797  -6.155 -16.610  1.00 96.14           C  \\nATOM   2074  C   SER A 263      -8.514  -5.191 -17.776  1.00 96.14           C  \\nATOM   2075  CB  SER A 263     -10.268  -6.125 -16.185  1.00 96.14           C  \\nATOM   2076  O   SER A 263      -9.381  -4.951 -18.621  1.00 96.14           O  \\nATOM   2077  OG  SER A 263     -10.502  -7.039 -15.134  1.00 96.14           O  \\nATOM   2078  N   GLY A 264      -7.296  -4.643 -17.851  1.00 97.16           N  \\nATOM   2079  CA  GLY A 264      -6.818  -3.802 -18.956  1.00 97.16           C  \\nATOM   2080  C   GLY A 264      -7.079  -2.302 -18.785  1.00 97.16           C  \\nATOM   2081  O   GLY A 264      -6.789  -1.509 -19.683  1.00 97.16           O  \\nATOM   2082  N   GLU A 265      -7.583  -1.853 -17.630  1.00 98.06           N  \\nATOM   2083  CA  GLU A 265      -7.887  -0.436 -17.378  1.00 98.06           C  \\nATOM   2084  C   GLU A 265      -6.649   0.467 -17.447  1.00 98.06           C  \\nATOM   2085  CB  GLU A 265      -8.536  -0.229 -16.001  1.00 98.06           C  \\nATOM   2086  O   GLU A 265      -6.768   1.675 -17.686  1.00 98.06           O  \\nATOM   2087  CG  GLU A 265      -9.840  -1.006 -15.787  1.00 98.06           C  \\nATOM   2088  CD  GLU A 265      -9.653  -2.440 -15.266  1.00 98.06           C  \\nATOM   2089  OE1 GLU A 265     -10.686  -3.038 -14.924  1.00 98.06           O  \\nATOM   2090  OE2 GLU A 265      -8.503  -2.945 -15.240  1.00 98.06           O  \\nATOM   2091  N   LEU A 266      -5.466  -0.114 -17.240  1.00 97.86           N  \\nATOM   2092  CA  LEU A 266      -4.183   0.579 -17.202  1.00 97.86           C  \\nATOM   2093  C   LEU A 266      -3.289   0.299 -18.413  1.00 97.86           C  \\nATOM   2094  CB  LEU A 266      -3.471   0.252 -15.876  1.00 97.86           C  \\nATOM   2095  O   LEU A 266      -2.186   0.836 -18.452  1.00 97.86           O  \\nATOM   2096  CG  LEU A 266      -4.158   0.841 -14.632  1.00 97.86           C  \\nATOM   2097  CD1 LEU A 266      -3.342   0.483 -13.395  1.00 97.86           C  \\nATOM   2098  CD2 LEU A 266      -4.250   2.369 -14.718  1.00 97.86           C  \\nATOM   2099  N   ASP A 267      -3.738  -0.468 -19.413  1.00 98.02           N  \\nATOM   2100  CA  ASP A 267      -2.878  -0.949 -20.507  1.00 98.02           C  \\nATOM   2101  C   ASP A 267      -2.108   0.159 -21.240  1.00 98.02           C  \\nATOM   2102  CB  ASP A 267      -3.721  -1.728 -21.535  1.00 98.02           C  \\nATOM   2103  O   ASP A 267      -0.954  -0.051 -21.616  1.00 98.02           O  \\nATOM   2104  CG  ASP A 267      -3.889  -3.213 -21.209  1.00 98.02           C  \\nATOM   2105  OD1 ASP A 267      -3.043  -3.739 -20.450  1.00 98.02           O  \\nATOM   2106  OD2 ASP A 267      -4.796  -3.822 -21.812  1.00 98.02           O  \\nATOM   2107  N   GLU A 268      -2.713   1.342 -21.409  1.00 97.04           N  \\nATOM   2108  CA  GLU A 268      -2.069   2.492 -22.068  1.00 97.04           C  \\nATOM   2109  C   GLU A 268      -0.940   3.131 -21.235  1.00 97.04           C  \\nATOM   2110  CB  GLU A 268      -3.121   3.541 -22.513  1.00 97.04           C  \\nATOM   2111  O   GLU A 268      -0.135   3.877 -21.783  1.00 97.04           O  \\nATOM   2112  CG  GLU A 268      -3.566   4.502 -21.396  1.00 97.04           C  \\nATOM   2113  CD  GLU A 268      -4.639   5.536 -21.801  1.00 97.04           C  \\nATOM   2114  OE1 GLU A 268      -5.689   5.561 -21.126  1.00 97.04           O  \\nATOM   2115  OE2 GLU A 268      -4.503   6.356 -22.742  1.00 97.04           O  \\nATOM   2116  N   PHE A 269      -0.885   2.859 -19.927  1.00 97.82           N  \\nATOM   2117  CA  PHE A 269       0.069   3.446 -18.979  1.00 97.82           C  \\nATOM   2118  C   PHE A 269       1.158   2.462 -18.523  1.00 97.82           C  \\nATOM   2119  CB  PHE A 269      -0.696   4.001 -17.765  1.00 97.82           C  \\nATOM   2120  O   PHE A 269       2.103   2.876 -17.851  1.00 97.82           O  \\nATOM   2121  CG  PHE A 269      -1.818   4.966 -18.098  1.00 97.82           C  \\nATOM   2122  CD1 PHE A 269      -1.528   6.207 -18.696  1.00 97.82           C  \\nATOM   2123  CD2 PHE A 269      -3.155   4.614 -17.836  1.00 97.82           C  \\nATOM   2124  CE1 PHE A 269      -2.571   7.082 -19.043  1.00 97.82           C  \\nATOM   2125  CE2 PHE A 269      -4.197   5.501 -18.157  1.00 97.82           C  \\nATOM   2126  CZ  PHE A 269      -3.902   6.735 -18.760  1.00 97.82           C  \\nATOM   2127  N   LEU A 270       1.030   1.172 -18.859  1.00 98.20           N  \\nATOM   2128  CA  LEU A 270       2.002   0.137 -18.500  1.00 98.20           C  \\nATOM   2129  C   LEU A 270       3.204   0.156 -19.453  1.00 98.20           C  \\nATOM   2130  CB  LEU A 270       1.331  -1.250 -18.498  1.00 98.20           C  \\nATOM   2131  O   LEU A 270       3.077  -0.166 -20.639  1.00 98.20           O  \\nATOM   2132  CG  LEU A 270       0.242  -1.474 -17.436  1.00 98.20           C  \\nATOM   2133  CD1 LEU A 270      -0.336  -2.879 -17.590  1.00 98.20           C  \\nATOM   2134  CD2 LEU A 270       0.761  -1.310 -16.009  1.00 98.20           C  \\nATOM   2135  N   LEU A 271       4.379   0.470 -18.906  1.00 98.45           N  \\nATOM   2136  CA  LEU A 271       5.666   0.434 -19.603  1.00 98.45           C  \\nATOM   2137  C   LEU A 271       6.234  -0.991 -19.658  1.00 98.45           C  \\nATOM   2138  CB  LEU A 271       6.662   1.391 -18.917  1.00 98.45           C  \\nATOM   2139  O   LEU A 271       5.788  -1.891 -18.943  1.00 98.45           O  \\nATOM   2140  CG  LEU A 271       6.203   2.855 -18.789  1.00 98.45           C  \\nATOM   2141  CD1 LEU A 271       7.339   3.685 -18.185  1.00 98.45           C  \\nATOM   2142  CD2 LEU A 271       5.819   3.466 -20.135  1.00 98.45           C  \\nATOM   2143  N   GLU A 272       7.276  -1.198 -20.470  1.00 98.04           N  \\nATOM   2144  CA  GLU A 272       7.961  -2.498 -20.566  1.00 98.04           C  \\nATOM   2145  C   GLU A 272       8.487  -2.991 -19.207  1.00 98.04           C  \\nATOM   2146  CB  GLU A 272       9.079  -2.445 -21.627  1.00 98.04           C  \\nATOM   2147  O   GLU A 272       8.361  -4.169 -18.877  1.00 98.04           O  \\nATOM   2148  CG  GLU A 272      10.266  -1.503 -21.322  1.00 98.04           C  \\nATOM   2149  CD  GLU A 272      11.382  -1.551 -22.390  1.00 98.04           C  \\nATOM   2150  OE1 GLU A 272      12.395  -0.827 -22.232  1.00 98.04           O  \\nATOM   2151  OE2 GLU A 272      11.247  -2.332 -23.359  1.00 98.04           O  \\nATOM   2152  N   TYR A 273       8.988  -2.076 -18.371  1.00 98.48           N  \\nATOM   2153  CA  TYR A 273       9.506  -2.386 -17.037  1.00 98.48           C  \\nATOM   2154  C   TYR A 273       8.415  -2.924 -16.105  1.00 98.48           C  \\nATOM   2155  CB  TYR A 273      10.134  -1.123 -16.426  1.00 98.48           C  \\nATOM   2156  O   TYR A 273       8.669  -3.834 -15.318  1.00 98.48           O  \\nATOM   2157  CG  TYR A 273      10.944  -0.288 -17.399  1.00 98.48           C  \\nATOM   2158  CD1 TYR A 273      12.227  -0.703 -17.796  1.00 98.48           C  \\nATOM   2159  CD2 TYR A 273      10.380   0.875 -17.958  1.00 98.48           C  \\nATOM   2160  CE1 TYR A 273      12.960   0.064 -18.720  1.00 98.48           C  \\nATOM   2161  CE2 TYR A 273      11.100   1.629 -18.902  1.00 98.48           C  \\nATOM   2162  OH  TYR A 273      13.087   1.988 -20.168  1.00 98.48           O  \\nATOM   2163  CZ  TYR A 273      12.397   1.231 -19.279  1.00 98.48           C  \\nATOM   2164  N   ASP A 274       7.197  -2.390 -16.217  1.00 98.54           N  \\nATOM   2165  CA  ASP A 274       6.060  -2.796 -15.387  1.00 98.54           C  \\nATOM   2166  C   ASP A 274       5.639  -4.225 -15.722  1.00 98.54           C  \\nATOM   2167  CB  ASP A 274       4.884  -1.830 -15.592  1.00 98.54           C  \\nATOM   2168  O   ASP A 274       5.402  -5.035 -14.826  1.00 98.54           O  \\nATOM   2169  CG  ASP A 274       5.280  -0.378 -15.344  1.00 98.54           C  \\nATOM   2170  OD1 ASP A 274       6.015  -0.100 -14.375  1.00 98.54           O  \\nATOM   2171  OD2 ASP A 274       4.887   0.508 -16.131  1.00 98.54           O  \\nATOM   2172  N   ARG A 275       5.633  -4.555 -17.019  1.00 98.30           N  \\nATOM   2173  CA  ARG A 275       5.326  -5.899 -17.519  1.00 98.30           C  \\nATOM   2174  C   ARG A 275       6.375  -6.911 -17.065  1.00 98.30           C  \\nATOM   2175  CB  ARG A 275       5.174  -5.872 -19.048  1.00 98.30           C  \\nATOM   2176  O   ARG A 275       6.015  -7.959 -16.547  1.00 98.30           O  \\nATOM   2177  CG  ARG A 275       4.015  -4.956 -19.475  1.00 98.30           C  \\nATOM   2178  CD  ARG A 275       3.858  -4.901 -20.998  1.00 98.30           C  \\nATOM   2179  NE  ARG A 275       2.940  -3.814 -21.398  1.00 98.30           N  \\nATOM   2180  NH1 ARG A 275       0.916  -4.865 -21.028  1.00 98.30           N  \\nATOM   2181  NH2 ARG A 275       0.957  -2.754 -21.732  1.00 98.30           N  \\nATOM   2182  CZ  ARG A 275       1.616  -3.824 -21.389  1.00 98.30           C  \\nATOM   2183  N   LEU A 276       7.663  -6.567 -17.131  1.00 98.10           N  \\nATOM   2184  CA  LEU A 276       8.739  -7.432 -16.626  1.00 98.10           C  \\nATOM   2185  C   LEU A 276       8.645  -7.674 -15.109  1.00 98.10           C  \\nATOM   2186  CB  LEU A 276      10.094  -6.795 -16.972  1.00 98.10           C  \\nATOM   2187  O   LEU A 276       8.878  -8.792 -14.634  1.00 98.10           O  \\nATOM   2188  CG  LEU A 276      10.466  -6.829 -18.464  1.00 98.10           C  \\nATOM   2189  CD1 LEU A 276      11.753  -6.026 -18.669  1.00 98.10           C  \\nATOM   2190  CD2 LEU A 276      10.705  -8.254 -18.967  1.00 98.10           C  \\nATOM   2191  N   VAL A 277       8.300  -6.643 -14.329  1.00 98.15           N  \\nATOM   2192  CA  VAL A 277       8.047  -6.792 -12.886  1.00 98.15           C  \\nATOM   2193  C   VAL A 277       6.864  -7.719 -12.634  1.00 98.15           C  \\nATOM   2194  CB  VAL A 277       7.816  -5.425 -12.211  1.00 98.15           C  \\nATOM   2195  O   VAL A 277       6.956  -8.594 -11.769  1.00 98.15           O  \\nATOM   2196  CG1 VAL A 277       7.245  -5.540 -10.791  1.00 98.15           C  \\nATOM   2197  CG2 VAL A 277       9.152  -4.703 -12.076  1.00 98.15           C  \\nATOM   2198  N   ASP A 278       5.776  -7.544 -13.382  1.00 97.23           N  \\nATOM   2199  CA  ASP A 278       4.562  -8.341 -13.261  1.00 97.23           C  \\nATOM   2200  C   ASP A 278       4.784  -9.817 -13.621  1.00 97.23           C  \\nATOM   2201  CB  ASP A 278       3.455  -7.721 -14.122  1.00 97.23           C  \\nATOM   2202  O   ASP A 278       4.536 -10.689 -12.785  1.00 97.23           O  \\nATOM   2203  CG  ASP A 278       2.202  -8.581 -14.029  1.00 97.23           C  \\nATOM   2204  OD1 ASP A 278       1.765  -8.816 -12.883  1.00 97.23           O  \\nATOM   2205  OD2 ASP A 278       1.729  -9.105 -15.051  1.00 97.23           O  \\nATOM   2206  N   GLU A 279       5.335 -10.093 -14.804  1.00 97.16           N  \\nATOM   2207  CA  GLU A 279       5.606 -11.440 -15.327  1.00 97.16           C  \\nATOM   2208  C   GLU A 279       6.470 -12.269 -14.378  1.00 97.16           C  \\nATOM   2209  CB  GLU A 279       6.371 -11.318 -16.652  1.00 97.16           C  \\nATOM   2210  O   GLU A 279       6.290 -13.477 -14.222  1.00 97.16           O  \\nATOM   2211  CG  GLU A 279       5.481 -10.901 -17.831  1.00 97.16           C  \\nATOM   2212  CD  GLU A 279       6.294 -10.577 -19.096  1.00 97.16           C  \\nATOM   2213  OE1 GLU A 279       5.681 -10.053 -20.054  1.00 97.16           O  \\nATOM   2214  OE2 GLU A 279       7.513 -10.876 -19.124  1.00 97.16           O  \\nATOM   2215  N   SER A 280       7.419 -11.610 -13.720  1.00 93.40           N  \\nATOM   2216  CA  SER A 280       8.335 -12.260 -12.796  1.00 93.40           C  \\nATOM   2217  C   SER A 280       7.784 -12.325 -11.362  1.00 93.40           C  \\nATOM   2218  CB  SER A 280       9.701 -11.581 -12.934  1.00 93.40           C  \\nATOM   2219  O   SER A 280       8.391 -12.952 -10.488  1.00 93.40           O  \\nATOM   2220  OG  SER A 280       9.684 -10.234 -12.495  1.00 93.40           O  \\nATOM   2221  N   SER A 281       6.676 -11.647 -11.054  1.00 91.88           N  \\nATOM   2222  CA  SER A 281       6.115 -11.562  -9.700  1.00 91.88           C  \\nATOM   2223  C   SER A 281       5.527 -12.890  -9.200  1.00 91.88           C  \\nATOM   2224  CB  SER A 281       5.074 -10.441  -9.620  1.00 91.88           C  \\nATOM   2225  O   SER A 281       5.396 -13.873  -9.924  1.00 91.88           O  \\nATOM   2226  OG  SER A 281       3.869 -10.853 -10.217  1.00 91.88           O  \\nATOM   2227  N   ALA A 282       5.154 -12.926  -7.919  1.00 85.51           N  \\nATOM   2228  CA  ALA A 282       4.499 -14.086  -7.315  1.00 85.51           C  \\nATOM   2229  C   ALA A 282       3.087 -14.349  -7.875  1.00 85.51           C  \\nATOM   2230  CB  ALA A 282       4.453 -13.843  -5.802  1.00 85.51           C  \\nATOM   2231  O   ALA A 282       2.582 -15.464  -7.715  1.00 85.51           O  \\nATOM   2232  N   ASN A 283       2.484 -13.332  -8.489  1.00 88.03           N  \\nATOM   2233  CA  ASN A 283       1.105 -13.255  -8.949  1.00 88.03           C  \\nATOM   2234  C   ASN A 283       1.030 -12.463 -10.277  1.00 88.03           C  \\nATOM   2235  CB  ASN A 283       0.261 -12.631  -7.811  1.00 88.03           C  \\nATOM   2236  O   ASN A 283       0.561 -11.323 -10.268  1.00 88.03           O  \\nATOM   2237  CG  ASN A 283       0.723 -11.254  -7.330  1.00 88.03           C  \\nATOM   2238  ND2 ASN A 283      -0.206 -10.380  -7.029  1.00 88.03           N  \\nATOM   2239  OD1 ASN A 283       1.905 -10.956  -7.174  1.00 88.03           O  \\nATOM   2240  N   PRO A 284       1.546 -13.006 -11.398  1.00 94.19           N  \\nATOM   2241  CA  PRO A 284       1.499 -12.335 -12.701  1.00 94.19           C  \\nATOM   2242  C   PRO A 284       0.066 -12.041 -13.155  1.00 94.19           C  \\nATOM   2243  CB  PRO A 284       2.210 -13.269 -13.685  1.00 94.19           C  \\nATOM   2244  O   PRO A 284      -0.837 -12.841 -12.900  1.00 94.19           O  \\nATOM   2245  CG  PRO A 284       3.109 -14.115 -12.787  1.00 94.19           C  \\nATOM   2246  CD  PRO A 284       2.259 -14.270 -11.530  1.00 94.19           C  \\nATOM   2247  N   GLY A 285      -0.136 -10.906 -13.825  1.00 95.18           N  \\nATOM   2248  CA  GLY A 285      -1.443 -10.429 -14.280  1.00 95.18           C  \\nATOM   2249  C   GLY A 285      -2.371  -9.947 -13.163  1.00 95.18           C  \\nATOM   2250  O   GLY A 285      -3.550  -9.736 -13.418  1.00 95.18           O  \\nATOM   2251  N   GLN A 286      -1.867  -9.813 -11.932  1.00 94.36           N  \\nATOM   2252  CA  GLN A 286      -2.654  -9.382 -10.775  1.00 94.36           C  \\nATOM   2253  C   GLN A 286      -1.982  -8.241 -10.022  1.00 94.36           C  \\nATOM   2254  CB  GLN A 286      -2.886 -10.540  -9.797  1.00 94.36           C  \\nATOM   2255  O   GLN A 286      -0.753  -8.176  -9.961  1.00 94.36           O  \\nATOM   2256  CG  GLN A 286      -3.666 -11.711 -10.399  1.00 94.36           C  \\nATOM   2257  CD  GLN A 286      -3.872 -12.832  -9.386  1.00 94.36           C  \\nATOM   2258  NE2 GLN A 286      -4.129 -14.037  -9.841  1.00 94.36           N  \\nATOM   2259  OE1 GLN A 286      -3.775 -12.669  -8.178  1.00 94.36           O  \\nATOM   2260  N   GLN A 287      -2.763  -7.426  -9.317  1.00 94.94           N  \\nATOM   2261  CA  GLN A 287      -2.246  -6.348  -8.465  1.00 94.94           C  \\nATOM   2262  C   GLN A 287      -1.394  -5.330  -9.248  1.00 94.94           C  \\nATOM   2263  CB  GLN A 287      -1.528  -6.916  -7.219  1.00 94.94           C  \\nATOM   2264  O   GLN A 287      -0.367  -4.849  -8.753  1.00 94.94           O  \\nATOM   2265  CG  GLN A 287      -2.417  -7.828  -6.361  1.00 94.94           C  \\nATOM   2266  CD  GLN A 287      -3.572  -7.083  -5.702  1.00 94.94           C  \\nATOM   2267  NE2 GLN A 287      -4.671  -7.746  -5.423  1.00 94.94           N  \\nATOM   2268  OE1 GLN A 287      -3.498  -5.907  -5.395  1.00 94.94           O  \\nATOM   2269  N   LEU A 288      -1.768  -5.044 -10.501  1.00 97.51           N  \\nATOM   2270  CA  LEU A 288      -0.963  -4.210 -11.396  1.00 97.51           C  \\nATOM   2271  C   LEU A 288      -0.801  -2.780 -10.869  1.00 97.51           C  \\nATOM   2272  CB  LEU A 288      -1.572  -4.229 -12.807  1.00 97.51           C  \\nATOM   2273  O   LEU A 288       0.307  -2.244 -10.882  1.00 97.51           O  \\nATOM   2274  CG  LEU A 288      -1.497  -5.599 -13.511  1.00 97.51           C  \\nATOM   2275  CD1 LEU A 288      -2.082  -5.485 -14.914  1.00 97.51           C  \\nATOM   2276  CD2 LEU A 288      -0.063  -6.107 -13.663  1.00 97.51           C  \\nATOM   2277  N   TYR A 289      -1.856  -2.175 -10.326  1.00 98.38           N  \\nATOM   2278  CA  TYR A 289      -1.767  -0.839  -9.740  1.00 98.38           C  \\nATOM   2279  C   TYR A 289      -0.888  -0.800  -8.485  1.00 98.38           C  \\nATOM   2280  CB  TYR A 289      -3.175  -0.343  -9.444  1.00 98.38           C  \\nATOM   2281  O   TYR A 289      -0.071   0.112  -8.328  1.00 98.38           O  \\nATOM   2282  CG  TYR A 289      -3.264   1.107  -9.069  1.00 98.38           C  \\nATOM   2283  CD1 TYR A 289      -3.743   1.468  -7.800  1.00 98.38           C  \\nATOM   2284  CD2 TYR A 289      -2.959   2.084 -10.035  1.00 98.38           C  \\nATOM   2285  CE1 TYR A 289      -3.944   2.820  -7.496  1.00 98.38           C  \\nATOM   2286  CE2 TYR A 289      -3.178   3.439  -9.747  1.00 98.38           C  \\nATOM   2287  OH  TYR A 289      -3.919   5.077  -8.179  1.00 98.38           O  \\nATOM   2288  CZ  TYR A 289      -3.677   3.791  -8.478  1.00 98.38           C  \\nATOM   2289  N   GLU A 290      -0.971  -1.824  -7.626  1.00 97.42           N  \\nATOM   2290  CA  GLU A 290      -0.045  -1.967  -6.497  1.00 97.42           C  \\nATOM   2291  C   GLU A 290       1.408  -2.078  -6.986  1.00 97.42           C  \\nATOM   2292  CB  GLU A 290      -0.430  -3.165  -5.603  1.00 97.42           C  \\nATOM   2293  O   GLU A 290       2.296  -1.465  -6.394  1.00 97.42           O  \\nATOM   2294  CG  GLU A 290       0.555  -3.313  -4.433  1.00 97.42           C  \\nATOM   2295  CD  GLU A 290       0.189  -4.395  -3.404  1.00 97.42           C  \\nATOM   2296  OE1 GLU A 290       0.736  -5.522  -3.515  1.00 97.42           O  \\nATOM   2297  OE2 GLU A 290      -0.456  -4.029  -2.394  1.00 97.42           O  \\nATOM   2298  N   LYS A 291       1.670  -2.795  -8.085  1.00 97.14           N  \\nATOM   2299  CA  LYS A 291       3.019  -2.950  -8.659  1.00 97.14           C  \\nATOM   2300  C   LYS A 291       3.625  -1.650  -9.183  1.00 97.14           C  \\nATOM   2301  CB  LYS A 291       3.004  -4.040  -9.738  1.00 97.14           C  \\nATOM   2302  O   LYS A 291       4.843  -1.489  -9.128  1.00 97.14           O  \\nATOM   2303  CG  LYS A 291       2.933  -5.432  -9.101  1.00 97.14           C  \\nATOM   2304  CD  LYS A 291       2.498  -6.484 -10.118  1.00 97.14           C  \\nATOM   2305  CE  LYS A 291       2.535  -7.857  -9.451  1.00 97.14           C  \\nATOM   2306  NZ  LYS A 291       1.838  -8.853 -10.278  1.00 97.14           N  \\nATOM   2307  N   LEU A 292       2.798  -0.702  -9.618  1.00 98.11           N  \\nATOM   2308  CA  LEU A 292       3.253   0.615 -10.076  1.00 98.11           C  \\nATOM   2309  C   LEU A 292       3.658   1.559  -8.933  1.00 98.11           C  \\nATOM   2310  CB  LEU A 292       2.140   1.260 -10.918  1.00 98.11           C  \\nATOM   2311  O   LEU A 292       4.398   2.515  -9.172  1.00 98.11           O  \\nATOM   2312  CG  LEU A 292       1.820   0.529 -12.233  1.00 98.11           C  \\nATOM   2313  CD1 LEU A 292       0.645   1.226 -12.910  1.00 98.11           C  \\nATOM   2314  CD2 LEU A 292       3.003   0.535 -13.194  1.00 98.11           C  \\nATOM   2315  N   ILE A 293       3.155   1.328  -7.715  1.00 98.28           N  \\nATOM   2316  CA  ILE A 293       3.244   2.282  -6.595  1.00 98.28           C  \\nATOM   2317  C   ILE A 293       4.026   1.709  -5.410  1.00 98.28           C  \\nATOM   2318  CB  ILE A 293       1.820   2.713  -6.161  1.00 98.28           C  \\nATOM   2319  O   ILE A 293       4.834   2.402  -4.788  1.00 98.28           O  \\nATOM   2320  CG1 ILE A 293       1.051   3.387  -7.323  1.00 98.28           C  \\nATOM   2321  CG2 ILE A 293       1.889   3.676  -4.955  1.00 98.28           C  \\nATOM   2322  CD1 ILE A 293      -0.457   3.490  -7.073  1.00 98.28           C  \\nATOM   2323  N   GLY A 294       3.755   0.450  -5.073  1.00 95.52           N  \\nATOM   2324  CA  GLY A 294       4.204  -0.208  -3.858  1.00 95.52           C  \\nATOM   2325  C   GLY A 294       5.722  -0.292  -3.757  1.00 95.52           C  \\nATOM   2326  O   GLY A 294       6.438  -0.655  -4.695  1.00 95.52           O  \\nATOM   2327  N   GLY A 295       6.225  -0.031  -2.556  1.00 95.57           N  \\nATOM   2328  CA  GLY A 295       7.639  -0.114  -2.221  1.00 95.57           C  \\nATOM   2329  C   GLY A 295       8.224  -1.517  -2.371  1.00 95.57           C  \\nATOM   2330  O   GLY A 295       9.442  -1.649  -2.400  1.00 95.57           O  \\nATOM   2331  N   LYS A 296       7.410  -2.568  -2.519  1.00 93.42           N  \\nATOM   2332  CA  LYS A 296       7.898  -3.898  -2.906  1.00 93.42           C  \\nATOM   2333  C   LYS A 296       8.521  -3.922  -4.308  1.00 93.42           C  \\nATOM   2334  CB  LYS A 296       6.737  -4.896  -2.795  1.00 93.42           C  \\nATOM   2335  O   LYS A 296       9.429  -4.712  -4.548  1.00 93.42           O  \\nATOM   2336  CG  LYS A 296       7.193  -6.312  -3.152  1.00 93.42           C  \\nATOM   2337  CD  LYS A 296       6.186  -7.380  -2.732  1.00 93.42           C  \\nATOM   2338  CE  LYS A 296       6.840  -8.716  -3.083  1.00 93.42           C  \\nATOM   2339  NZ  LYS A 296       6.147  -9.857  -2.458  1.00 93.42           N  \\nATOM   2340  N   TYR A 297       8.043  -3.073  -5.215  1.00 96.72           N  \\nATOM   2341  CA  TYR A 297       8.346  -3.151  -6.647  1.00 96.72           C  \\nATOM   2342  C   TYR A 297       9.165  -1.961  -7.158  1.00 96.72           C  \\nATOM   2343  CB  TYR A 297       7.017  -3.272  -7.396  1.00 96.72           C  \\nATOM   2344  O   TYR A 297       9.899  -2.095  -8.133  1.00 96.72           O  \\nATOM   2345  CG  TYR A 297       6.135  -4.409  -6.905  1.00 96.72           C  \\nATOM   2346  CD1 TYR A 297       6.422  -5.743  -7.255  1.00 96.72           C  \\nATOM   2347  CD2 TYR A 297       5.030  -4.125  -6.078  1.00 96.72           C  \\nATOM   2348  CE1 TYR A 297       5.582  -6.786  -6.813  1.00 96.72           C  \\nATOM   2349  CE2 TYR A 297       4.173  -5.158  -5.661  1.00 96.72           C  \\nATOM   2350  OH  TYR A 297       3.609  -7.479  -5.622  1.00 96.72           O  \\nATOM   2351  CZ  TYR A 297       4.443  -6.489  -6.032  1.00 96.72           C  \\nATOM   2352  N   MET A 298       9.103  -0.817  -6.469  1.00 98.22           N  \\nATOM   2353  CA  MET A 298       9.765   0.429  -6.876  1.00 98.22           C  \\nATOM   2354  C   MET A 298      11.270   0.276  -7.151  1.00 98.22           C  \\nATOM   2355  CB  MET A 298       9.504   1.475  -5.786  1.00 98.22           C  \\nATOM   2356  O   MET A 298      11.760   0.751  -8.174  1.00 98.22           O  \\nATOM   2357  CG  MET A 298       9.989   2.872  -6.184  1.00 98.22           C  \\nATOM   2358  SD  MET A 298       9.701   4.144  -4.925  1.00 98.22           S  \\nATOM   2359  CE  MET A 298       7.887   4.211  -4.938  1.00 98.22           C  \\nATOM   2360  N   GLY A 299      12.009  -0.406  -6.272  1.00 98.36           N  \\nATOM   2361  CA  GLY A 299      13.436  -0.659  -6.481  1.00 98.36           C  \\nATOM   2362  C   GLY A 299      13.728  -1.521  -7.716  1.00 98.36           C  \\nATOM   2363  O   GLY A 299      14.647  -1.219  -8.477  1.00 98.36           O  \\nATOM   2364  N   GLU A 300      12.901  -2.537  -7.974  1.00 98.34           N  \\nATOM   2365  CA  GLU A 300      13.043  -3.397  -9.153  1.00 98.34           C  \\nATOM   2366  C   GLU A 300      12.731  -2.641 -10.450  1.00 98.34           C  \\nATOM   2367  CB  GLU A 300      12.157  -4.643  -8.992  1.00 98.34           C  \\nATOM   2368  O   GLU A 300      13.454  -2.800 -11.432  1.00 98.34           O  \\nATOM   2369  CG  GLU A 300      12.235  -5.614 -10.179  1.00 98.34           C  \\nATOM   2370  CD  GLU A 300      13.619  -6.212 -10.433  1.00 98.34           C  \\nATOM   2371  OE1 GLU A 300      13.808  -6.854 -11.486  1.00 98.34           O  \\nATOM   2372  OE2 GLU A 300      14.535  -6.108  -9.586  1.00 98.34           O  \\nATOM   2373  N   LEU A 301      11.724  -1.761 -10.443  1.00 98.71           N  \\nATOM   2374  CA  LEU A 301      11.445  -0.869 -11.571  1.00 98.71           C  \\nATOM   2375  C   LEU A 301      12.659   0.005 -11.895  1.00 98.71           C  \\nATOM   2376  CB  LEU A 301      10.222   0.009 -11.256  1.00 98.71           C  \\nATOM   2377  O   LEU A 301      13.086   0.059 -13.047  1.00 98.71           O  \\nATOM   2378  CG  LEU A 301       8.881  -0.739 -11.284  1.00 98.71           C  \\nATOM   2379  CD1 LEU A 301       7.787   0.165 -10.718  1.00 98.71           C  \\nATOM   2380  CD2 LEU A 301       8.504  -1.137 -12.710  1.00 98.71           C  \\nATOM   2381  N   VAL A 302      13.272   0.626 -10.880  1.00 98.81           N  \\nATOM   2382  CA  VAL A 302      14.509   1.396 -11.075  1.00 98.81           C  \\nATOM   2383  C   VAL A 302      15.614   0.504 -11.632  1.00 98.81           C  \\nATOM   2384  CB  VAL A 302      14.957   2.105  -9.782  1.00 98.81           C  \\nATOM   2385  O   VAL A 302      16.250   0.881 -12.611  1.00 98.81           O  \\nATOM   2386  CG1 VAL A 302      16.337   2.761  -9.930  1.00 98.81           C  \\nATOM   2387  CG2 VAL A 302      13.962   3.215  -9.421  1.00 98.81           C  \\nATOM   2388  N   ARG A 303      15.823  -0.697 -11.078  1.00 98.70           N  \\nATOM   2389  CA  ARG A 303      16.848  -1.638 -11.558  1.00 98.70           C  \\nATOM   2390  C   ARG A 303      16.712  -1.927 -13.052  1.00 98.70           C  \\nATOM   2391  CB  ARG A 303      16.740  -2.956 -10.784  1.00 98.70           C  \\nATOM   2392  O   ARG A 303      17.713  -1.900 -13.764  1.00 98.70           O  \\nATOM   2393  CG  ARG A 303      18.019  -3.794 -10.913  1.00 98.70           C  \\nATOM   2394  CD  ARG A 303      17.806  -5.187 -10.317  1.00 98.70           C  \\nATOM   2395  NE  ARG A 303      16.832  -5.958 -11.106  1.00 98.70           N  \\nATOM   2396  NH1 ARG A 303      18.259  -6.743 -12.698  1.00 98.70           N  \\nATOM   2397  NH2 ARG A 303      16.087  -7.198 -12.854  1.00 98.70           N  \\nATOM   2398  CZ  ARG A 303      17.059  -6.619 -12.219  1.00 98.70           C  \\nATOM   2399  N   LEU A 304      15.493  -2.193 -13.520  1.00 98.78           N  \\nATOM   2400  CA  LEU A 304      15.219  -2.487 -14.926  1.00 98.78           C  \\nATOM   2401  C   LEU A 304      15.481  -1.271 -15.825  1.00 98.78           C  \\nATOM   2402  CB  LEU A 304      13.774  -2.985 -15.068  1.00 98.78           C  \\nATOM   2403  O   LEU A 304      16.093  -1.425 -16.879  1.00 98.78           O  \\nATOM   2404  CG  LEU A 304      13.496  -4.354 -14.425  1.00 98.78           C  \\nATOM   2405  CD1 LEU A 304      11.992  -4.592 -14.431  1.00 98.78           C  \\nATOM   2406  CD2 LEU A 304      14.170  -5.495 -15.191  1.00 98.78           C  \\nATOM   2407  N   VAL A 305      15.125  -0.061 -15.378  1.00 98.70           N  \\nATOM   2408  CA  VAL A 305      15.486   1.186 -16.079  1.00 98.70           C  \\nATOM   2409  C   VAL A 305      17.005   1.345 -16.160  1.00 98.70           C  \\nATOM   2410  CB  VAL A 305      14.853   2.414 -15.397  1.00 98.70           C  \\nATOM   2411  O   VAL A 305      17.538   1.677 -17.217  1.00 98.70           O  \\nATOM   2412  CG1 VAL A 305      15.287   3.738 -16.041  1.00 98.70           C  \\nATOM   2413  CG2 VAL A 305      13.329   2.360 -15.487  1.00 98.70           C  \\nATOM   2414  N   LEU A 306      17.735   1.066 -15.074  1.00 98.72           N  \\nATOM   2415  CA  LEU A 306      19.199   1.127 -15.086  1.00 98.72           C  \\nATOM   2416  C   LEU A 306      19.797   0.117 -16.071  1.00 98.72           C  \\nATOM   2417  CB  LEU A 306      19.786   0.923 -13.677  1.00 98.72           C  \\nATOM   2418  O   LEU A 306      20.716   0.477 -16.802  1.00 98.72           O  \\nATOM   2419  CG  LEU A 306      19.394   1.964 -12.612  1.00 98.72           C  \\nATOM   2420  CD1 LEU A 306      20.190   1.705 -11.332  1.00 98.72           C  \\nATOM   2421  CD2 LEU A 306      19.605   3.410 -13.055  1.00 98.72           C  \\nATOM   2422  N   LEU A 307      19.273  -1.112 -16.134  1.00 98.55           N  \\nATOM   2423  CA  LEU A 307      19.714  -2.104 -17.119  1.00 98.55           C  \\nATOM   2424  C   LEU A 307      19.454  -1.641 -18.554  1.00 98.55           C  \\nATOM   2425  CB  LEU A 307      19.044  -3.464 -16.871  1.00 98.55           C  \\nATOM   2426  O   LEU A 307      20.363  -1.707 -19.376  1.00 98.55           O  \\nATOM   2427  CG  LEU A 307      19.543  -4.239 -15.641  1.00 98.55           C  \\nATOM   2428  CD1 LEU A 307      18.869  -5.612 -15.646  1.00 98.55           C  \\nATOM   2429  CD2 LEU A 307      21.059  -4.461 -15.631  1.00 98.55           C  \\nATOM   2430  N   ARG A 308      18.277  -1.074 -18.838  1.00 98.34           N  \\nATOM   2431  CA  ARG A 308      17.972  -0.504 -20.157  1.00 98.34           C  \\nATOM   2432  C   ARG A 308      18.960   0.594 -20.550  1.00 98.34           C  \\nATOM   2433  CB  ARG A 308      16.529   0.018 -20.136  1.00 98.34           C  \\nATOM   2434  O   ARG A 308      19.440   0.623 -21.681  1.00 98.34           O  \\nATOM   2435  CG  ARG A 308      16.047   0.578 -21.479  1.00 98.34           C  \\nATOM   2436  CD  ARG A 308      15.855  -0.542 -22.501  1.00 98.34           C  \\nATOM   2437  NE  ARG A 308      15.251  -0.015 -23.732  1.00 98.34           N  \\nATOM   2438  NH1 ARG A 308      16.741  -0.899 -25.219  1.00 98.34           N  \\nATOM   2439  NH2 ARG A 308      15.385   0.701 -25.894  1.00 98.34           N  \\nATOM   2440  CZ  ARG A 308      15.770  -0.087 -24.936  1.00 98.34           C  \\nATOM   2441  N   LEU A 309      19.299   1.483 -19.616  1.00 98.53           N  \\nATOM   2442  CA  LEU A 309      20.278   2.548 -19.845  1.00 98.53           C  \\nATOM   2443  C   LEU A 309      21.697   2.003 -20.062  1.00 98.53           C  \\nATOM   2444  CB  LEU A 309      20.249   3.527 -18.661  1.00 98.53           C  \\nATOM   2445  O   LEU A 309      22.455   2.577 -20.845  1.00 98.53           O  \\nATOM   2446  CG  LEU A 309      18.951   4.346 -18.532  1.00 98.53           C  \\nATOM   2447  CD1 LEU A 309      18.957   5.083 -17.194  1.00 98.53           C  \\nATOM   2448  CD2 LEU A 309      18.828   5.380 -19.650  1.00 98.53           C  \\nATOM   2449  N   VAL A 310      22.067   0.906 -19.399  1.00 98.14           N  \\nATOM   2450  CA  VAL A 310      23.329   0.199 -19.656  1.00 98.14           C  \\nATOM   2451  C   VAL A 310      23.323  -0.403 -21.061  1.00 98.14           C  \\nATOM   2452  CB  VAL A 310      23.591  -0.873 -18.584  1.00 98.14           C  \\nATOM   2453  O   VAL A 310      24.246  -0.136 -21.825  1.00 98.14           O  \\nATOM   2454  CG1 VAL A 310      24.771  -1.775 -18.942  1.00 98.14           C  \\nATOM   2455  CG2 VAL A 310      23.937  -0.232 -17.232  1.00 98.14           C  \\nATOM   2456  N   ASP A 311      22.278  -1.139 -21.438  1.00 97.49           N  \\nATOM   2457  CA  ASP A 311      22.187  -1.809 -22.744  1.00 97.49           C  \\nATOM   2458  C   ASP A 311      22.213  -0.811 -23.917  1.00 97.49           C  \\nATOM   2459  CB  ASP A 311      20.910  -2.667 -22.787  1.00 97.49           C  \\nATOM   2460  O   ASP A 311      22.756  -1.094 -24.984  1.00 97.49           O  \\nATOM   2461  CG  ASP A 311      20.930  -3.879 -21.842  1.00 97.49           C  \\nATOM   2462  OD1 ASP A 311      22.031  -4.302 -21.414  1.00 97.49           O  \\nATOM   2463  OD2 ASP A 311      19.826  -4.410 -21.587  1.00 97.49           O  \\nATOM   2464  N   GLU A 312      21.702   0.405 -23.705  1.00 96.99           N  \\nATOM   2465  CA  GLU A 312      21.763   1.519 -24.663  1.00 96.99           C  \\nATOM   2466  C   GLU A 312      23.104   2.292 -24.641  1.00 96.99           C  \\nATOM   2467  CB  GLU A 312      20.552   2.440 -24.424  1.00 96.99           C  \\nATOM   2468  O   GLU A 312      23.244   3.314 -25.322  1.00 96.99           O  \\nATOM   2469  CG  GLU A 312      19.209   1.790 -24.820  1.00 96.99           C  \\nATOM   2470  CD  GLU A 312      19.022   1.608 -26.337  1.00 96.99           C  \\nATOM   2471  OE1 GLU A 312      18.115   0.847 -26.747  1.00 96.99           O  \\nATOM   2472  OE2 GLU A 312      19.724   2.291 -27.120  1.00 96.99           O  \\nATOM   2473  N   ASN A 313      24.096   1.816 -23.875  1.00 96.35           N  \\nATOM   2474  CA  ASN A 313      25.411   2.430 -23.642  1.00 96.35           C  \\nATOM   2475  C   ASN A 313      25.336   3.868 -23.079  1.00 96.35           C  \\nATOM   2476  CB  ASN A 313      26.283   2.264 -24.898  1.00 96.35           C  \\nATOM   2477  O   ASN A 313      26.169   4.735 -23.363  1.00 96.35           O  \\nATOM   2478  CG  ASN A 313      27.757   2.531 -24.648  1.00 96.35           C  \\nATOM   2479  ND2 ASN A 313      28.493   2.884 -25.676  1.00 96.35           N  \\nATOM   2480  OD1 ASN A 313      28.288   2.416 -23.558  1.00 96.35           O  \\nATOM   2481  N   LEU A 314      24.309   4.138 -22.270  1.00 97.14           N  \\nATOM   2482  CA  LEU A 314      24.054   5.426 -21.618  1.00 97.14           C  \\nATOM   2483  C   LEU A 314      24.451   5.429 -20.140  1.00 97.14           C  \\nATOM   2484  CB  LEU A 314      22.571   5.801 -21.764  1.00 97.14           C  \\nATOM   2485  O   LEU A 314      24.515   6.492 -19.525  1.00 97.14           O  \\nATOM   2486  CG  LEU A 314      22.081   5.917 -23.213  1.00 97.14           C  \\nATOM   2487  CD1 LEU A 314      20.569   6.102 -23.224  1.00 97.14           C  \\nATOM   2488  CD2 LEU A 314      22.740   7.092 -23.938  1.00 97.14           C  \\nATOM   2489  N   LEU A 315      24.764   4.279 -19.556  1.00 97.24           N  \\nATOM   2490  CA  LEU A 315      25.126   4.177 -18.148  1.00 97.24           C  \\nATOM   2491  C   LEU A 315      26.269   3.179 -17.958  1.00 97.24           C  \\nATOM   2492  CB  LEU A 315      23.848   3.809 -17.377  1.00 97.24           C  \\nATOM   2493  O   LEU A 315      26.328   2.168 -18.654  1.00 97.24           O  \\nATOM   2494  CG  LEU A 315      23.966   3.931 -15.856  1.00 97.24           C  \\nATOM   2495  CD1 LEU A 315      24.131   5.377 -15.392  1.00 97.24           C  \\nATOM   2496  CD2 LEU A 315      22.707   3.368 -15.203  1.00 97.24           C  \\nATOM   2497  N   PHE A 316      27.201   3.494 -17.053  1.00 96.73           N  \\nATOM   2498  CA  PHE A 316      28.316   2.614 -16.661  1.00 96.73           C  \\nATOM   2499  C   PHE A 316      29.141   2.072 -17.842  1.00 96.73           C  \\nATOM   2500  CB  PHE A 316      27.819   1.491 -15.731  1.00 96.73           C  \\nATOM   2501  O   PHE A 316      29.593   0.933 -17.824  1.00 96.73           O  \\nATOM   2502  CG  PHE A 316      26.925   1.931 -14.588  1.00 96.73           C  \\nATOM   2503  CD1 PHE A 316      27.260   3.053 -13.805  1.00 96.73           C  \\nATOM   2504  CD2 PHE A 316      25.735   1.227 -14.325  1.00 96.73           C  \\nATOM   2505  CE1 PHE A 316      26.384   3.488 -12.796  1.00 96.73           C  \\nATOM   2506  CE2 PHE A 316      24.856   1.671 -13.323  1.00 96.73           C  \\nATOM   2507  CZ  PHE A 316      25.177   2.810 -12.567  1.00 96.73           C  \\nATOM   2508  N   HIS A 317      29.327   2.885 -18.888  1.00 93.79           N  \\nATOM   2509  CA  HIS A 317      30.048   2.502 -20.113  1.00 93.79           C  \\nATOM   2510  C   HIS A 317      29.492   1.252 -20.822  1.00 93.79           C  \\nATOM   2511  CB  HIS A 317      31.557   2.401 -19.824  1.00 93.79           C  \\nATOM   2512  O   HIS A 317      30.238   0.553 -21.503  1.00 93.79           O  \\nATOM   2513  CG  HIS A 317      32.133   3.653 -19.224  1.00 93.79           C  \\nATOM   2514  CD2 HIS A 317      32.505   3.853 -17.922  1.00 93.79           C  \\nATOM   2515  ND1 HIS A 317      32.372   4.822 -19.904  1.00 93.79           N  \\nATOM   2516  CE1 HIS A 317      32.881   5.708 -19.035  1.00 93.79           C  \\nATOM   2517  NE2 HIS A 317      32.988   5.166 -17.814  1.00 93.79           N  \\nATOM   2518  N   GLY A 318      28.196   0.972 -20.660  1.00 95.50           N  \\nATOM   2519  CA  GLY A 318      27.554  -0.188 -21.273  1.00 95.50           C  \\nATOM   2520  C   GLY A 318      27.805  -1.506 -20.540  1.00 95.50           C  \\nATOM   2521  O   GLY A 318      27.440  -2.565 -21.043  1.00 95.50           O  \\nATOM   2522  N   GLU A 319      28.394  -1.462 -19.341  1.00 95.89           N  \\nATOM   2523  CA  GLU A 319      28.722  -2.649 -18.554  1.00 95.89           C  \\nATOM   2524  C   GLU A 319      28.010  -2.636 -17.192  1.00 95.89           C  \\nATOM   2525  CB  GLU A 319      30.246  -2.777 -18.400  1.00 95.89           C  \\nATOM   2526  O   GLU A 319      28.374  -1.909 -16.268  1.00 95.89           O  \\nATOM   2527  CG  GLU A 319      30.957  -3.041 -19.741  1.00 95.89           C  \\nATOM   2528  CD  GLU A 319      32.474  -3.271 -19.600  1.00 95.89           C  \\nATOM   2529  OE1 GLU A 319      33.126  -3.494 -20.647  1.00 95.89           O  \\nATOM   2530  OE2 GLU A 319      32.993  -3.250 -18.458  1.00 95.89           O  \\nATOM   2531  N   ALA A 320      26.994  -3.489 -17.039  1.00 95.63           N  \\nATOM   2532  CA  ALA A 320      26.408  -3.780 -15.733  1.00 95.63           C  \\nATOM   2533  C   ALA A 320      27.305  -4.745 -14.940  1.00 95.63           C  \\nATOM   2534  CB  ALA A 320      24.980  -4.325 -15.887  1.00 95.63           C  \\nATOM   2535  O   ALA A 320      27.967  -5.618 -15.510  1.00 95.63           O  \\nATOM   2536  N   SER A 321      27.271  -4.629 -13.615  1.00 96.81           N  \\nATOM   2537  CA  SER A 321      27.836  -5.621 -12.700  1.00 96.81           C  \\nATOM   2538  C   SER A 321      26.909  -6.832 -12.547  1.00 96.81           C  \\nATOM   2539  CB  SER A 321      28.071  -4.974 -11.337  1.00 96.81           C  \\nATOM   2540  O   SER A 321      25.699  -6.742 -12.767  1.00 96.81           O  \\nATOM   2541  OG  SER A 321      26.828  -4.565 -10.802  1.00 96.81           O  \\nATOM   2542  N   GLU A 322      27.456  -7.960 -12.092  1.00 96.83           N  \\nATOM   2543  CA  GLU A 322      26.658  -9.156 -11.780  1.00 96.83           C  \\nATOM   2544  C   GLU A 322      25.626  -8.890 -10.672  1.00 96.83           C  \\nATOM   2545  CB  GLU A 322      27.597 -10.309 -11.380  1.00 96.83           C  \\nATOM   2546  O   GLU A 322      24.499  -9.388 -10.716  1.00 96.83           O  \\nATOM   2547  CG  GLU A 322      28.507 -10.764 -12.533  1.00 96.83           C  \\nATOM   2548  CD  GLU A 322      27.678 -11.120 -13.774  1.00 96.83           C  \\nATOM   2549  OE1 GLU A 322      27.706 -10.327 -14.747  1.00 96.83           O  \\nATOM   2550  OE2 GLU A 322      26.942 -12.124 -13.706  1.00 96.83           O  \\nATOM   2551  N   GLN A 323      25.966  -8.029  -9.709  1.00 97.05           N  \\nATOM   2552  CA  GLN A 323      25.046  -7.605  -8.657  1.00 97.05           C  \\nATOM   2553  C   GLN A 323      23.870  -6.806  -9.231  1.00 97.05           C  \\nATOM   2554  CB  GLN A 323      25.773  -6.777  -7.587  1.00 97.05           C  \\nATOM   2555  O   GLN A 323      22.733  -7.102  -8.886  1.00 97.05           O  \\nATOM   2556  CG  GLN A 323      26.843  -7.539  -6.787  1.00 97.05           C  \\nATOM   2557  CD  GLN A 323      28.213  -7.650  -7.458  1.00 97.05           C  \\nATOM   2558  NE2 GLN A 323      29.206  -8.132  -6.746  1.00 97.05           N  \\nATOM   2559  OE1 GLN A 323      28.439  -7.316  -8.611  1.00 97.05           O  \\nATOM   2560  N   LEU A 324      24.099  -5.847 -10.140  1.00 97.70           N  \\nATOM   2561  CA  LEU A 324      23.008  -5.074 -10.752  1.00 97.70           C  \\nATOM   2562  C   LEU A 324      22.108  -5.951 -11.645  1.00 97.70           C  \\nATOM   2563  CB  LEU A 324      23.600  -3.885 -11.535  1.00 97.70           C  \\nATOM   2564  O   LEU A 324      20.893  -5.740 -11.710  1.00 97.70           O  \\nATOM   2565  CG  LEU A 324      22.538  -2.964 -12.173  1.00 97.70           C  \\nATOM   2566  CD1 LEU A 324      21.685  -2.252 -11.120  1.00 97.70           C  \\nATOM   2567  CD2 LEU A 324      23.201  -1.899 -13.046  1.00 97.70           C  \\nATOM   2568  N   ARG A 325      22.685  -6.962 -12.309  1.00 97.47           N  \\nATOM   2569  CA  ARG A 325      21.923  -7.949 -13.095  1.00 97.47           C  \\nATOM   2570  C   ARG A 325      21.019  -8.827 -12.232  1.00 97.47           C  \\nATOM   2571  CB  ARG A 325      22.873  -8.830 -13.920  1.00 97.47           C  \\nATOM   2572  O   ARG A 325      20.005  -9.314 -12.731  1.00 97.47           O  \\nATOM   2573  CG  ARG A 325      23.494  -8.067 -15.094  1.00 97.47           C  \\nATOM   2574  CD  ARG A 325      24.284  -9.023 -15.994  1.00 97.47           C  \\nATOM   2575  NE  ARG A 325      24.871  -8.296 -17.133  1.00 97.47           N  \\nATOM   2576  NH1 ARG A 325      27.025  -8.113 -16.318  1.00 97.47           N  \\nATOM   2577  NH2 ARG A 325      26.423  -6.957 -18.112  1.00 97.47           N  \\nATOM   2578  CZ  ARG A 325      26.097  -7.808 -17.179  1.00 97.47           C  \\nATOM   2579  N   THR A 326      21.343  -8.998 -10.953  1.00 97.57           N  \\nATOM   2580  CA  THR A 326      20.552  -9.812 -10.028  1.00 97.57           C  \\nATOM   2581  C   THR A 326      19.220  -9.128  -9.710  1.00 97.57           C  \\nATOM   2582  CB  THR A 326      21.353 -10.127  -8.757  1.00 97.57           C  \\nATOM   2583  O   THR A 326      19.175  -7.986  -9.251  1.00 97.57           O  \\nATOM   2584  CG2 THR A 326      20.591 -11.056  -7.812  1.00 97.57           C  \\nATOM   2585  OG1 THR A 326      22.546 -10.803  -9.099  1.00 97.57           O  \\nATOM   2586  N   ARG A 327      18.110  -9.830  -9.957  1.00 96.12           N  \\nATOM   2587  CA  ARG A 327      16.754  -9.351  -9.657  1.00 96.12           C  \\nATOM   2588  C   ARG A 327      16.603  -8.997  -8.176  1.00 96.12           C  \\nATOM   2589  CB  ARG A 327      15.743 -10.416 -10.093  1.00 96.12           C  \\nATOM   2590  O   ARG A 327      17.056  -9.747  -7.318  1.00 96.12           O  \\nATOM   2591  CG  ARG A 327      14.312  -9.953  -9.823  1.00 96.12           C  \\nATOM   2592  CD  ARG A 327      13.318 -10.949 -10.393  1.00 96.12           C  \\nATOM   2593  NE  ARG A 327      11.955 -10.493 -10.112  1.00 96.12           N  \\nATOM   2594  NH1 ARG A 327      10.994 -12.557  -9.903  1.00 96.12           N  \\nATOM   2595  NH2 ARG A 327       9.753 -10.723  -9.661  1.00 96.12           N  \\nATOM   2596  CZ  ARG A 327      10.914 -11.256  -9.884  1.00 96.12           C  \\nATOM   2597  N   GLY A 328      15.954  -7.871  -7.885  1.00 94.61           N  \\nATOM   2598  CA  GLY A 328      15.738  -7.391  -6.520  1.00 94.61           C  \\nATOM   2599  C   GLY A 328      16.977  -6.800  -5.839  1.00 94.61           C  \\nATOM   2600  O   GLY A 328      16.873  -6.358  -4.700  1.00 94.61           O  \\nATOM   2601  N   ALA A 329      18.137  -6.745  -6.509  1.00 96.69           N  \\nATOM   2602  CA  ALA A 329      19.364  -6.212  -5.910  1.00 96.69           C  \\nATOM   2603  C   ALA A 329      19.336  -4.690  -5.693  1.00 96.69           C  \\nATOM   2604  CB  ALA A 329      20.546  -6.606  -6.795  1.00 96.69           C  \\nATOM   2605  O   ALA A 329      20.056  -4.180  -4.836  1.00 96.69           O  \\nATOM   2606  N   PHE A 330      18.517  -3.954  -6.453  1.00 98.18           N  \\nATOM   2607  CA  PHE A 330      18.291  -2.531  -6.214  1.00 98.18           C  \\nATOM   2608  C   PHE A 330      17.053  -2.358  -5.333  1.00 98.18           C  \\nATOM   2609  CB  PHE A 330      18.209  -1.752  -7.530  1.00 98.18           C  \\nATOM   2610  O   PHE A 330      15.921  -2.365  -5.803  1.00 98.18           O  \\nATOM   2611  CG  PHE A 330      18.499  -0.275  -7.364  1.00 98.18           C  \\nATOM   2612  CD1 PHE A 330      17.498   0.602  -6.905  1.00 98.18           C  \\nATOM   2613  CD2 PHE A 330      19.783   0.223  -7.653  1.00 98.18           C  \\nATOM   2614  CE1 PHE A 330      17.788   1.967  -6.733  1.00 98.18           C  \\nATOM   2615  CE2 PHE A 330      20.071   1.588  -7.482  1.00 98.18           C  \\nATOM   2616  CZ  PHE A 330      19.070   2.462  -7.024  1.00 98.18           C  \\nATOM   2617  N   GLU A 331      17.263  -2.250  -4.027  1.00 96.58           N  \\nATOM   2618  CA  GLU A 331      16.176  -2.151  -3.056  1.00 96.58           C  \\nATOM   2619  C   GLU A 331      15.514  -0.764  -3.060  1.00 96.58           C  \\nATOM   2620  CB  GLU A 331      16.723  -2.457  -1.661  1.00 96.58           C  \\nATOM   2621  O   GLU A 331      16.160   0.258  -3.286  1.00 96.58           O  \\nATOM   2622  CG  GLU A 331      17.264  -3.885  -1.498  1.00 96.58           C  \\nATOM   2623  CD  GLU A 331      17.944  -4.008  -0.133  1.00 96.58           C  \\nATOM   2624  OE1 GLU A 331      19.180  -4.192  -0.077  1.00 96.58           O  \\nATOM   2625  OE2 GLU A 331      17.285  -3.723   0.892  1.00 96.58           O  \\nATOM   2626  N   THR A 332      14.236  -0.688  -2.688  1.00 97.31           N  \\nATOM   2627  CA  THR A 332      13.499   0.588  -2.594  1.00 97.31           C  \\nATOM   2628  C   THR A 332      14.137   1.589  -1.627  1.00 97.31           C  \\nATOM   2629  CB  THR A 332      12.048   0.305  -2.207  1.00 97.31           C  \\nATOM   2630  O   THR A 332      14.095   2.793  -1.866  1.00 97.31           O  \\nATOM   2631  CG2 THR A 332      11.182   1.554  -2.054  1.00 97.31           C  \\nATOM   2632  OG1 THR A 332      11.527  -0.469  -3.257  1.00 97.31           O  \\nATOM   2633  N   ARG A 333      14.827   1.123  -0.575  1.00 96.92           N  \\nATOM   2634  CA  ARG A 333      15.606   2.013   0.304  1.00 96.92           C  \\nATOM   2635  C   ARG A 333      16.711   2.765  -0.446  1.00 96.92           C  \\nATOM   2636  CB  ARG A 333      16.165   1.240   1.509  1.00 96.92           C  \\nATOM   2637  O   ARG A 333      17.026   3.888  -0.064  1.00 96.92           O  \\nATOM   2638  CG  ARG A 333      17.238   0.212   1.120  1.00 96.92           C  \\nATOM   2639  CD  ARG A 333      17.720  -0.582   2.334  1.00 96.92           C  \\nATOM   2640  NE  ARG A 333      18.690  -1.605   1.925  1.00 96.92           N  \\nATOM   2641  NH1 ARG A 333      20.629  -0.408   2.133  1.00 96.92           N  \\nATOM   2642  NH2 ARG A 333      20.692  -2.507   1.376  1.00 96.92           N  \\nATOM   2643  CZ  ARG A 333      19.997  -1.504   1.814  1.00 96.92           C  \\nATOM   2644  N   PHE A 334      17.283   2.182  -1.503  1.00 98.17           N  \\nATOM   2645  CA  PHE A 334      18.263   2.868  -2.342  1.00 98.17           C  \\nATOM   2646  C   PHE A 334      17.620   3.986  -3.157  1.00 98.17           C  \\nATOM   2647  CB  PHE A 334      18.988   1.889  -3.272  1.00 98.17           C  \\nATOM   2648  O   PHE A 334      18.245   5.029  -3.302  1.00 98.17           O  \\nATOM   2649  CG  PHE A 334      19.825   0.815  -2.603  1.00 98.17           C  \\nATOM   2650  CD1 PHE A 334      20.549   1.076  -1.423  1.00 98.17           C  \\nATOM   2651  CD2 PHE A 334      19.958  -0.432  -3.234  1.00 98.17           C  \\nATOM   2652  CE1 PHE A 334      21.404   0.096  -0.893  1.00 98.17           C  \\nATOM   2653  CE2 PHE A 334      20.781  -1.428  -2.681  1.00 98.17           C  \\nATOM   2654  CZ  PHE A 334      21.510  -1.161  -1.512  1.00 98.17           C  \\nATOM   2655  N   VAL A 335      16.370   3.824  -3.606  1.00 98.49           N  \\nATOM   2656  CA  VAL A 335      15.610   4.893  -4.281  1.00 98.49           C  \\nATOM   2657  C   VAL A 335      15.489   6.109  -3.358  1.00 98.49           C  \\nATOM   2658  CB  VAL A 335      14.217   4.411  -4.743  1.00 98.49           C  \\nATOM   2659  O   VAL A 335      15.945   7.198  -3.712  1.00 98.49           O  \\nATOM   2660  CG1 VAL A 335      13.522   5.460  -5.615  1.00 98.49           C  \\nATOM   2661  CG2 VAL A 335      14.302   3.115  -5.563  1.00 98.49           C  \\nATOM   2662  N   SER A 336      15.013   5.905  -2.123  1.00 97.98           N  \\nATOM   2663  CA  SER A 336      14.899   6.980  -1.128  1.00 97.98           C  \\nATOM   2664  C   SER A 336      16.247   7.628  -0.802  1.00 97.98           C  \\nATOM   2665  CB  SER A 336      14.296   6.456   0.181  1.00 97.98           C  \\nATOM   2666  O   SER A 336      16.342   8.848  -0.676  1.00 97.98           O  \\nATOM   2667  OG  SER A 336      13.047   5.835  -0.043  1.00 97.98           O  \\nATOM   2668  N   GLN A 337      17.304   6.824  -0.666  1.00 97.83           N  \\nATOM   2669  CA  GLN A 337      18.648   7.309  -0.348  1.00 97.83           C  \\nATOM   2670  C   GLN A 337      19.269   8.113  -1.496  1.00 97.83           C  \\nATOM   2671  CB  GLN A 337      19.538   6.114   0.007  1.00 97.83           C  \\nATOM   2672  O   GLN A 337      19.897   9.136  -1.245  1.00 97.83           O  \\nATOM   2673  CG  GLN A 337      19.282   5.582   1.424  1.00 97.83           C  \\nATOM   2674  CD  GLN A 337      20.141   4.370   1.775  1.00 97.83           C  \\nATOM   2675  NE2 GLN A 337      20.156   3.967   3.026  1.00 97.83           N  \\nATOM   2676  OE1 GLN A 337      20.843   3.777   0.972  1.00 97.83           O  \\nATOM   2677  N   VAL A 338      19.078   7.681  -2.744  1.00 98.21           N  \\nATOM   2678  CA  VAL A 338      19.546   8.400  -3.935  1.00 98.21           C  \\nATOM   2679  C   VAL A 338      18.861   9.761  -4.050  1.00 98.21           C  \\nATOM   2680  CB  VAL A 338      19.325   7.539  -5.196  1.00 98.21           C  \\nATOM   2681  O   VAL A 338      19.533  10.760  -4.296  1.00 98.21           O  \\nATOM   2682  CG1 VAL A 338      19.420   8.341  -6.496  1.00 98.21           C  \\nATOM   2683  CG2 VAL A 338      20.366   6.412  -5.278  1.00 98.21           C  \\nATOM   2684  N   GLU A 339      17.547   9.832  -3.827  1.00 97.40           N  \\nATOM   2685  CA  GLU A 339      16.816  11.108  -3.869  1.00 97.40           C  \\nATOM   2686  C   GLU A 339      17.084  12.019  -2.664  1.00 97.40           C  \\nATOM   2687  CB  GLU A 339      15.312  10.857  -4.028  1.00 97.40           C  \\nATOM   2688  O   GLU A 339      16.868  13.226  -2.758  1.00 97.40           O  \\nATOM   2689  CG  GLU A 339      14.998  10.443  -5.467  1.00 97.40           C  \\nATOM   2690  CD  GLU A 339      13.502  10.504  -5.770  1.00 97.40           C  \\nATOM   2691  OE1 GLU A 339      12.998   9.538  -6.366  1.00 97.40           O  \\nATOM   2692  OE2 GLU A 339      12.828  11.535  -5.494  1.00 97.40           O  \\nATOM   2693  N   SER A 340      17.595  11.470  -1.559  1.00 96.59           N  \\nATOM   2694  CA  SER A 340      18.015  12.247  -0.384  1.00 96.59           C  \\nATOM   2695  C   SER A 340      19.433  12.823  -0.509  1.00 96.59           C  \\nATOM   2696  CB  SER A 340      17.928  11.401   0.888  1.00 96.59           C  \\nATOM   2697  O   SER A 340      19.869  13.557   0.379  1.00 96.59           O  \\nATOM   2698  OG  SER A 340      16.627  10.882   1.087  1.00 96.59           O  \\nATOM   2699  N   ASP A 341      20.172  12.502  -1.580  1.00 95.32           N  \\nATOM   2700  CA  ASP A 341      21.537  12.992  -1.779  1.00 95.32           C  \\nATOM   2701  C   ASP A 341      21.554  14.524  -1.928  1.00 95.32           C  \\nATOM   2702  CB  ASP A 341      22.202  12.281  -2.970  1.00 95.32           C  \\nATOM   2703  O   ASP A 341      20.827  15.121  -2.736  1.00 95.32           O  \\nATOM   2704  CG  ASP A 341      23.699  12.604  -3.116  1.00 95.32           C  \\nATOM   2705  OD1 ASP A 341      24.016  13.744  -3.536  1.00 95.32           O  \\nATOM   2706  OD2 ASP A 341      24.541  11.703  -2.874  1.00 95.32           O  \\nATOM   2707  N   THR A 342      22.439  15.159  -1.158  1.00 87.19           N  \\nATOM   2708  CA  THR A 342      22.571  16.620  -1.035  1.00 87.19           C  \\nATOM   2709  C   THR A 342      23.100  17.301  -2.302  1.00 87.19           C  \\nATOM   2710  CB  THR A 342      23.482  16.972   0.152  1.00 87.19           C  \\nATOM   2711  O   THR A 342      23.176  18.528  -2.353  1.00 87.19           O  \\nATOM   2712  CG2 THR A 342      22.951  16.442   1.486  1.00 87.19           C  \\nATOM   2713  OG1 THR A 342      24.759  16.408  -0.045  1.00 87.19           O  \\nATOM   2714  N   GLY A 343      23.463  16.525  -3.329  1.00 88.28           N  \\nATOM   2715  CA  GLY A 343      24.045  16.983  -4.589  1.00 88.28           C  \\nATOM   2716  C   GLY A 343      25.556  16.751  -4.680  1.00 88.28           C  \\nATOM   2717  O   GLY A 343      26.143  16.958  -5.744  1.00 88.28           O  \\nATOM   2718  N   ASP A 344      26.197  16.296  -3.596  1.00 92.51           N  \\nATOM   2719  CA  ASP A 344      27.616  15.926  -3.600  1.00 92.51           C  \\nATOM   2720  C   ASP A 344      27.880  14.522  -4.176  1.00 92.51           C  \\nATOM   2721  CB  ASP A 344      28.261  16.183  -2.224  1.00 92.51           C  \\nATOM   2722  O   ASP A 344      29.037  14.176  -4.432  1.00 92.51           O  \\nATOM   2723  CG  ASP A 344      28.088  15.097  -1.154  1.00 92.51           C  \\nATOM   2724  OD1 ASP A 344      27.431  14.068  -1.410  1.00 92.51           O  \\nATOM   2725  OD2 ASP A 344      28.753  15.256  -0.095  1.00 92.51           O  \\nATOM   2726  N   ARG A 345      26.810  13.759  -4.455  1.00 95.75           N  \\nATOM   2727  CA  ARG A 345      26.798  12.432  -5.091  1.00 95.75           C  \\nATOM   2728  C   ARG A 345      27.465  11.334  -4.270  1.00 95.75           C  \\nATOM   2729  CB  ARG A 345      27.377  12.488  -6.516  1.00 95.75           C  \\nATOM   2730  O   ARG A 345      27.610  10.220  -4.781  1.00 95.75           O  \\nATOM   2731  CG  ARG A 345      26.764  13.563  -7.421  1.00 95.75           C  \\nATOM   2732  CD  ARG A 345      27.605  13.657  -8.694  1.00 95.75           C  \\nATOM   2733  NE  ARG A 345      27.068  14.663  -9.612  1.00 95.75           N  \\nATOM   2734  NH1 ARG A 345      28.205  16.510  -8.874  1.00 95.75           N  \\nATOM   2735  NH2 ARG A 345      26.822  16.634 -10.649  1.00 95.75           N  \\nATOM   2736  CZ  ARG A 345      27.372  15.936  -9.701  1.00 95.75           C  \\nATOM   2737  N   LYS A 346      27.904  11.594  -3.034  1.00 95.92           N  \\nATOM   2738  CA  LYS A 346      28.626  10.591  -2.235  1.00 95.92           C  \\nATOM   2739  C   LYS A 346      27.734   9.415  -1.878  1.00 95.92           C  \\nATOM   2740  CB  LYS A 346      29.159  11.207  -0.942  1.00 95.92           C  \\nATOM   2741  O   LYS A 346      28.193   8.274  -1.895  1.00 95.92           O  \\nATOM   2742  CG  LYS A 346      30.309  12.184  -1.188  1.00 95.92           C  \\nATOM   2743  CD  LYS A 346      30.830  12.648   0.172  1.00 95.92           C  \\nATOM   2744  CE  LYS A 346      31.785  13.827   0.001  1.00 95.92           C  \\nATOM   2745  NZ  LYS A 346      31.323  14.949   0.842  1.00 95.92           N  \\nATOM   2746  N   GLN A 347      26.470   9.678  -1.561  1.00 96.68           N  \\nATOM   2747  CA  GLN A 347      25.531   8.630  -1.186  1.00 96.68           C  \\nATOM   2748  C   GLN A 347      25.226   7.736  -2.387  1.00 96.68           C  \\nATOM   2749  CB  GLN A 347      24.284   9.292  -0.601  1.00 96.68           C  \\nATOM   2750  O   GLN A 347      25.314   6.513  -2.280  1.00 96.68           O  \\nATOM   2751  CG  GLN A 347      23.278   8.281  -0.046  1.00 96.68           C  \\nATOM   2752  CD  GLN A 347      22.241   8.960   0.843  1.00 96.68           C  \\nATOM   2753  NE2 GLN A 347      21.460   8.205   1.576  1.00 96.68           N  \\nATOM   2754  OE1 GLN A 347      22.150  10.167   0.967  1.00 96.68           O  \\nATOM   2755  N   ILE A 348      24.983   8.352  -3.545  1.00 98.09           N  \\nATOM   2756  CA  ILE A 348      24.764   7.644  -4.812  1.00 98.09           C  \\nATOM   2757  C   ILE A 348      25.998   6.807  -5.177  1.00 98.09           C  \\nATOM   2758  CB  ILE A 348      24.400   8.641  -5.937  1.00 98.09           C  \\nATOM   2759  O   ILE A 348      25.877   5.616  -5.462  1.00 98.09           O  \\nATOM   2760  CG1 ILE A 348      23.217   9.550  -5.531  1.00 98.09           C  \\nATOM   2761  CG2 ILE A 348      24.068   7.851  -7.217  1.00 98.09           C  \\nATOM   2762  CD1 ILE A 348      22.910  10.669  -6.530  1.00 98.09           C  \\nATOM   2763  N   TYR A 349      27.196   7.395  -5.092  1.00 98.15           N  \\nATOM   2764  CA  TYR A 349      28.457   6.702  -5.365  1.00 98.15           C  \\nATOM   2765  C   TYR A 349      28.641   5.472  -4.465  1.00 98.15           C  \\nATOM   2766  CB  TYR A 349      29.629   7.682  -5.198  1.00 98.15           C  \\nATOM   2767  O   TYR A 349      29.009   4.401  -4.951  1.00 98.15           O  \\nATOM   2768  CG  TYR A 349      30.973   7.084  -5.568  1.00 98.15           C  \\nATOM   2769  CD1 TYR A 349      31.678   6.290  -4.641  1.00 98.15           C  \\nATOM   2770  CD2 TYR A 349      31.499   7.285  -6.858  1.00 98.15           C  \\nATOM   2771  CE1 TYR A 349      32.876   5.658  -5.021  1.00 98.15           C  \\nATOM   2772  CE2 TYR A 349      32.698   6.655  -7.243  1.00 98.15           C  \\nATOM   2773  OH  TYR A 349      34.527   5.197  -6.696  1.00 98.15           O  \\nATOM   2774  CZ  TYR A 349      33.382   5.830  -6.328  1.00 98.15           C  \\nATOM   2775  N   ASN A 350      28.362   5.601  -3.165  1.00 97.47           N  \\nATOM   2776  CA  ASN A 350      28.494   4.504  -2.207  1.00 97.47           C  \\nATOM   2777  C   ASN A 350      27.515   3.364  -2.504  1.00 97.47           C  \\nATOM   2778  CB  ASN A 350      28.298   5.044  -0.782  1.00 97.47           C  \\nATOM   2779  O   ASN A 350      27.929   2.208  -2.517  1.00 97.47           O  \\nATOM   2780  CG  ASN A 350      29.467   5.877  -0.290  1.00 97.47           C  \\nATOM   2781  ND2 ASN A 350      29.255   6.672   0.733  1.00 97.47           N  \\nATOM   2782  OD1 ASN A 350      30.586   5.805  -0.770  1.00 97.47           O  \\nATOM   2783  N   ILE A 351      26.248   3.674  -2.798  1.00 97.71           N  \\nATOM   2784  CA  ILE A 351      25.242   2.666  -3.169  1.00 97.71           C  \\nATOM   2785  C   ILE A 351      25.695   1.910  -4.416  1.00 97.71           C  \\nATOM   2786  CB  ILE A 351      23.864   3.332  -3.372  1.00 97.71           C  \\nATOM   2787  O   ILE A 351      25.800   0.686  -4.396  1.00 97.71           O  \\nATOM   2788  CG1 ILE A 351      23.329   3.817  -2.009  1.00 97.71           C  \\nATOM   2789  CG2 ILE A 351      22.851   2.374  -4.027  1.00 97.71           C  \\nATOM   2790  CD1 ILE A 351      22.163   4.799  -2.134  1.00 97.71           C  \\nATOM   2791  N   LEU A 352      26.057   2.621  -5.481  1.00 98.23           N  \\nATOM   2792  CA  LEU A 352      26.507   1.992  -6.723  1.00 98.23           C  \\nATOM   2793  C   LEU A 352      27.797   1.176  -6.524  1.00 98.23           C  \\nATOM   2794  CB  LEU A 352      26.670   3.096  -7.772  1.00 98.23           C  \\nATOM   2795  O   LEU A 352      27.936   0.097  -7.096  1.00 98.23           O  \\nATOM   2796  CG  LEU A 352      25.347   3.785  -8.163  1.00 98.23           C  \\nATOM   2797  CD1 LEU A 352      25.637   4.962  -9.091  1.00 98.23           C  \\nATOM   2798  CD2 LEU A 352      24.385   2.822  -8.859  1.00 98.23           C  \\nATOM   2799  N   SER A 353      28.695   1.620  -5.641  1.00 97.19           N  \\nATOM   2800  CA  SER A 353      29.888   0.853  -5.256  1.00 97.19           C  \\nATOM   2801  C   SER A 353      29.543  -0.465  -4.555  1.00 97.19           C  \\nATOM   2802  CB  SER A 353      30.812   1.679  -4.358  1.00 97.19           C  \\nATOM   2803  O   SER A 353      30.184  -1.480  -4.830  1.00 97.19           O  \\nATOM   2804  OG  SER A 353      31.270   2.841  -5.020  1.00 97.19           O  \\nATOM   2805  N   THR A 354      28.513  -0.495  -3.696  1.00 96.46           N  \\nATOM   2806  CA  THR A 354      28.027  -1.756  -3.089  1.00 96.46           C  \\nATOM   2807  C   THR A 354      27.432  -2.720  -4.113  1.00 96.46           C  \\nATOM   2808  CB  THR A 354      27.016  -1.554  -1.948  1.00 96.46           C  \\nATOM   2809  O   THR A 354      27.486  -3.931  -3.916  1.00 96.46           O  \\nATOM   2810  CG2 THR A 354      27.591  -0.755  -0.785  1.00 96.46           C  \\nATOM   2811  OG1 THR A 354      25.813  -0.930  -2.316  1.00 96.46           O  \\nATOM   2812  N   LEU A 355      26.956  -2.200  -5.246  1.00 96.99           N  \\nATOM   2813  CA  LEU A 355      26.518  -2.983  -6.400  1.00 96.99           C  \\nATOM   2814  C   LEU A 355      27.678  -3.339  -7.343  1.00 96.99           C  \\nATOM   2815  CB  LEU A 355      25.376  -2.241  -7.119  1.00 96.99           C  \\nATOM   2816  O   LEU A 355      27.434  -3.759  -8.465  1.00 96.99           O  \\nATOM   2817  CG  LEU A 355      24.112  -2.043  -6.262  1.00 96.99           C  \\nATOM   2818  CD1 LEU A 355      23.136  -1.131  -7.002  1.00 96.99           C  \\nATOM   2819  CD2 LEU A 355      23.409  -3.370  -5.971  1.00 96.99           C  \\nATOM   2820  N   GLY A 356      28.940  -3.181  -6.936  1.00 96.65           N  \\nATOM   2821  CA  GLY A 356      30.102  -3.558  -7.749  1.00 96.65           C  \\nATOM   2822  C   GLY A 356      30.396  -2.616  -8.922  1.00 96.65           C  \\nATOM   2823  O   GLY A 356      31.134  -2.996  -9.829  1.00 96.65           O  \\nATOM   2824  N   LEU A 357      29.838  -1.403  -8.922  1.00 96.66           N  \\nATOM   2825  CA  LEU A 357      30.019  -0.410  -9.984  1.00 96.66           C  \\nATOM   2826  C   LEU A 357      31.025   0.670  -9.561  1.00 96.66           C  \\nATOM   2827  CB  LEU A 357      28.656   0.199 -10.357  1.00 96.66           C  \\nATOM   2828  O   LEU A 357      31.198   0.960  -8.380  1.00 96.66           O  \\nATOM   2829  CG  LEU A 357      27.621  -0.835 -10.844  1.00 96.66           C  \\nATOM   2830  CD1 LEU A 357      26.217  -0.272 -10.668  1.00 96.66           C  \\nATOM   2831  CD2 LEU A 357      27.847  -1.199 -12.311  1.00 96.66           C  \\nATOM   2832  N   ARG A 358      31.679   1.307 -10.536  1.00 94.44           N  \\nATOM   2833  CA  ARG A 358      32.534   2.489 -10.324  1.00 94.44           C  \\nATOM   2834  C   ARG A 358      31.951   3.668 -11.104  1.00 94.44           C  \\nATOM   2835  CB  ARG A 358      33.983   2.190 -10.727  1.00 94.44           C  \\nATOM   2836  O   ARG A 358      32.379   3.903 -12.233  1.00 94.44           O  \\nATOM   2837  CG  ARG A 358      34.644   1.181  -9.784  1.00 94.44           C  \\nATOM   2838  CD  ARG A 358      36.095   0.975 -10.220  1.00 94.44           C  \\nATOM   2839  NE  ARG A 358      36.766  -0.035  -9.385  1.00 94.44           N  \\nATOM   2840  NH1 ARG A 358      38.642  -0.266 -10.683  1.00 94.44           N  \\nATOM   2841  NH2 ARG A 358      38.407  -1.515  -8.846  1.00 94.44           N  \\nATOM   2842  CZ  ARG A 358      37.932  -0.597  -9.639  1.00 94.44           C  \\nATOM   2843  N   PRO A 359      30.939   4.359 -10.557  1.00 95.90           N  \\nATOM   2844  CA  PRO A 359      30.183   5.345 -11.316  1.00 95.90           C  \\nATOM   2845  C   PRO A 359      30.984   6.634 -11.532  1.00 95.90           C  \\nATOM   2846  CB  PRO A 359      28.918   5.582 -10.493  1.00 95.90           C  \\nATOM   2847  O   PRO A 359      31.688   7.112 -10.639  1.00 95.90           O  \\nATOM   2848  CG  PRO A 359      29.421   5.399  -9.066  1.00 95.90           C  \\nATOM   2849  CD  PRO A 359      30.406   4.241  -9.202  1.00 95.90           C  \\nATOM   2850  N   SER A 360      30.835   7.232 -12.712  1.00 95.35           N  \\nATOM   2851  CA  SER A 360      31.219   8.625 -12.943  1.00 95.35           C  \\nATOM   2852  C   SER A 360      30.215   9.587 -12.293  1.00 95.35           C  \\nATOM   2853  CB  SER A 360      31.350   8.894 -14.446  1.00 95.35           C  \\nATOM   2854  O   SER A 360      29.111   9.202 -11.905  1.00 95.35           O  \\nATOM   2855  OG  SER A 360      30.088   8.869 -15.078  1.00 95.35           O  \\nATOM   2856  N   THR A 361      30.556  10.877 -12.223  1.00 94.67           N  \\nATOM   2857  CA  THR A 361      29.615  11.913 -11.760  1.00 94.67           C  \\nATOM   2858  C   THR A 361      28.344  11.952 -12.605  1.00 94.67           C  \\nATOM   2859  CB  THR A 361      30.263  13.304 -11.791  1.00 94.67           C  \\nATOM   2860  O   THR A 361      27.255  12.113 -12.065  1.00 94.67           O  \\nATOM   2861  CG2 THR A 361      31.375  13.423 -10.750  1.00 94.67           C  \\nATOM   2862  OG1 THR A 361      30.851  13.554 -13.053  1.00 94.67           O  \\nATOM   2863  N   THR A 362      28.481  11.760 -13.920  1.00 94.45           N  \\nATOM   2864  CA  THR A 362      27.354  11.707 -14.854  1.00 94.45           C  \\nATOM   2865  C   THR A 362      26.495  10.469 -14.624  1.00 94.45           C  \\nATOM   2866  CB  THR A 362      27.868  11.719 -16.300  1.00 94.45           C  \\nATOM   2867  O   THR A 362      25.277  10.572 -14.697  1.00 94.45           O  \\nATOM   2868  CG2 THR A 362      26.753  11.787 -17.342  1.00 94.45           C  \\nATOM   2869  OG1 THR A 362      28.689  12.847 -16.503  1.00 94.45           O  \\nATOM   2870  N   ASP A 363      27.092   9.317 -14.308  1.00 97.00           N  \\nATOM   2871  CA  ASP A 363      26.313   8.115 -13.993  1.00 97.00           C  \\nATOM   2872  C   ASP A 363      25.495   8.304 -12.709  1.00 97.00           C  \\nATOM   2873  CB  ASP A 363      27.206   6.880 -13.857  1.00 97.00           C  \\nATOM   2874  O   ASP A 363      24.325   7.933 -12.675  1.00 97.00           O  \\nATOM   2875  CG  ASP A 363      28.017   6.552 -15.109  1.00 97.00           C  \\nATOM   2876  OD1 ASP A 363      27.462   6.527 -16.232  1.00 97.00           O  \\nATOM   2877  OD2 ASP A 363      29.243   6.370 -14.938  1.00 97.00           O  \\nATOM   2878  N   CYS A 364      26.065   8.944 -11.679  1.00 97.84           N  \\nATOM   2879  CA  CYS A 364      25.316   9.287 -10.467  1.00 97.84           C  \\nATOM   2880  C   CYS A 364      24.115  10.198 -10.771  1.00 97.84           C  \\nATOM   2881  CB  CYS A 364      26.235   9.971  -9.446  1.00 97.84           C  \\nATOM   2882  O   CYS A 364      23.026   9.966 -10.248  1.00 97.84           O  \\nATOM   2883  SG  CYS A 364      27.482   8.823  -8.792  1.00 97.84           S  \\nATOM   2884  N   ASP A 365      24.298  11.204 -11.632  1.00 96.57           N  \\nATOM   2885  CA  ASP A 365      23.218  12.114 -12.029  1.00 96.57           C  \\nATOM   2886  C   ASP A 365      22.114  11.366 -12.800  1.00 96.57           C  \\nATOM   2887  CB  ASP A 365      23.786  13.295 -12.845  1.00 96.57           C  \\nATOM   2888  O   ASP A 365      20.932  11.572 -12.538  1.00 96.57           O  \\nATOM   2889  CG  ASP A 365      24.688  14.246 -12.036  1.00 96.57           C  \\nATOM   2890  OD1 ASP A 365      24.616  14.263 -10.790  1.00 96.57           O  \\nATOM   2891  OD2 ASP A 365      25.488  15.011 -12.627  1.00 96.57           O  \\nATOM   2892  N   ILE A 366      22.476  10.441 -13.695  1.00 97.98           N  \\nATOM   2893  CA  ILE A 366      21.510   9.618 -14.442  1.00 97.98           C  \\nATOM   2894  C   ILE A 366      20.736   8.680 -13.506  1.00 97.98           C  \\nATOM   2895  CB  ILE A 366      22.225   8.843 -15.570  1.00 97.98           C  \\nATOM   2896  O   ILE A 366      19.514   8.591 -13.610  1.00 97.98           O  \\nATOM   2897  CG1 ILE A 366      22.737   9.823 -16.651  1.00 97.98           C  \\nATOM   2898  CG2 ILE A 366      21.282   7.807 -16.209  1.00 97.98           C  \\nATOM   2899  CD1 ILE A 366      23.715   9.190 -17.646  1.00 97.98           C  \\nATOM   2900  N   VAL A 367      21.414   8.017 -12.563  1.00 98.54           N  \\nATOM   2901  CA  VAL A 367      20.761   7.141 -11.572  1.00 98.54           C  \\nATOM   2902  C   VAL A 367      19.773   7.930 -10.719  1.00 98.54           C  \\nATOM   2903  CB  VAL A 367      21.808   6.433 -10.692  1.00 98.54           C  \\nATOM   2904  O   VAL A 367      18.657   7.468 -10.492  1.00 98.54           O  \\nATOM   2905  CG1 VAL A 367      21.197   5.704  -9.486  1.00 98.54           C  \\nATOM   2906  CG2 VAL A 367      22.559   5.387 -11.522  1.00 98.54           C  \\nATOM   2907  N   ARG A 368      20.139   9.150 -10.306  1.00 98.12           N  \\nATOM   2908  CA  ARG A 368      19.220  10.052  -9.604  1.00 98.12           C  \\nATOM   2909  C   ARG A 368      17.973  10.346 -10.432  1.00 98.12           C  \\nATOM   2910  CB  ARG A 368      19.963  11.330  -9.203  1.00 98.12           C  \\nATOM   2911  O   ARG A 368      16.867  10.208  -9.918  1.00 98.12           O  \\nATOM   2912  CG  ARG A 368      19.072  12.262  -8.378  1.00 98.12           C  \\nATOM   2913  CD  ARG A 368      19.839  13.530  -8.013  1.00 98.12           C  \\nATOM   2914  NE  ARG A 368      18.976  14.444  -7.250  1.00 98.12           N  \\nATOM   2915  NH1 ARG A 368      20.544  15.197  -5.731  1.00 98.12           N  \\nATOM   2916  NH2 ARG A 368      18.407  15.731  -5.473  1.00 98.12           N  \\nATOM   2917  CZ  ARG A 368      19.317  15.126  -6.172  1.00 98.12           C  \\nATOM   2918  N   ARG A 369      18.138  10.691 -11.711  1.00 97.78           N  \\nATOM   2919  CA  ARG A 369      17.013  10.969 -12.619  1.00 97.78           C  \\nATOM   2920  C   ARG A 369      16.116   9.748 -12.830  1.00 97.78           C  \\nATOM   2921  CB  ARG A 369      17.541  11.503 -13.962  1.00 97.78           C  \\nATOM   2922  O   ARG A 369      14.897   9.906 -12.881  1.00 97.78           O  \\nATOM   2923  CG  ARG A 369      18.216  12.881 -13.872  1.00 97.78           C  \\nATOM   2924  CD  ARG A 369      17.252  14.011 -13.517  1.00 97.78           C  \\nATOM   2925  NE  ARG A 369      16.293  14.269 -14.605  1.00 97.78           N  \\nATOM   2926  NH1 ARG A 369      14.565  15.005 -13.275  1.00 97.78           N  \\nATOM   2927  NH2 ARG A 369      14.344  14.912 -15.526  1.00 97.78           N  \\nATOM   2928  CZ  ARG A 369      15.070  14.728 -14.456  1.00 97.78           C  \\nATOM   2929  N   ALA A 370      16.683   8.544 -12.904  1.00 98.71           N  \\nATOM   2930  CA  ALA A 370      15.912   7.305 -12.997  1.00 98.71           C  \\nATOM   2931  C   ALA A 370      15.062   7.065 -11.736  1.00 98.71           C  \\nATOM   2932  CB  ALA A 370      16.866   6.141 -13.289  1.00 98.71           C  \\nATOM   2933  O   ALA A 370      13.857   6.840 -11.853  1.00 98.71           O  \\nATOM   2934  N   CYS A 371      15.654   7.198 -10.541  1.00 98.71           N  \\nATOM   2935  CA  CYS A 371      14.924   7.123  -9.269  1.00 98.71           C  \\nATOM   2936  C   CYS A 371      13.780   8.148  -9.208  1.00 98.71           C  \\nATOM   2937  CB  CYS A 371      15.894   7.338  -8.098  1.00 98.71           C  \\nATOM   2938  O   CYS A 371      12.632   7.763  -8.988  1.00 98.71           O  \\nATOM   2939  SG  CYS A 371      16.998   5.911  -7.895  1.00 98.71           S  \\nATOM   2940  N   GLU A 372      14.083   9.421  -9.498  1.00 98.25           N  \\nATOM   2941  CA  GLU A 372      13.103  10.515  -9.503  1.00 98.25           C  \\nATOM   2942  C   GLU A 372      11.940  10.244 -10.462  1.00 98.25           C  \\nATOM   2943  CB  GLU A 372      13.785  11.841  -9.899  1.00 98.25           C  \\nATOM   2944  O   GLU A 372      10.793  10.547 -10.137  1.00 98.25           O  \\nATOM   2945  CG  GLU A 372      14.665  12.455  -8.795  1.00 98.25           C  \\nATOM   2946  CD  GLU A 372      15.472  13.693  -9.252  1.00 98.25           C  \\nATOM   2947  OE1 GLU A 372      16.250  14.217  -8.409  1.00 98.25           O  \\nATOM   2948  OE2 GLU A 372      15.337  14.122 -10.431  1.00 98.25           O  \\nATOM   2949  N   SER A 373      12.212   9.667 -11.634  1.00 98.67           N  \\nATOM   2950  CA  SER A 373      11.188   9.380 -12.645  1.00 98.67           C  \\nATOM   2951  C   SER A 373      10.227   8.285 -12.176  1.00 98.67           C  \\nATOM   2952  CB  SER A 373      11.845   8.999 -13.975  1.00 98.67           C  \\nATOM   2953  O   SER A 373       9.009   8.467 -12.228  1.00 98.67           O  \\nATOM   2954  OG  SER A 373      12.676  10.057 -14.414  1.00 98.67           O  \\nATOM   2955  N   VAL A 374      10.760   7.183 -11.637  1.00 98.79           N  \\nATOM   2956  CA  VAL A 374       9.952   6.068 -11.118  1.00 98.79           C  \\nATOM   2957  C   VAL A 374       9.122   6.505  -9.908  1.00 98.79           C  \\nATOM   2958  CB  VAL A 374      10.841   4.856 -10.768  1.00 98.79           C  \\nATOM   2959  O   VAL A 374       7.913   6.266  -9.874  1.00 98.79           O  \\nATOM   2960  CG1 VAL A 374      10.036   3.714 -10.132  1.00 98.79           C  \\nATOM   2961  CG2 VAL A 374      11.514   4.283 -12.022  1.00 98.79           C  \\nATOM   2962  N   SER A 375       9.735   7.180  -8.931  1.00 98.58           N  \\nATOM   2963  CA  SER A 375       9.045   7.597  -7.705  1.00 98.58           C  \\nATOM   2964  C   SER A 375       8.007   8.698  -7.964  1.00 98.58           C  \\nATOM   2965  CB  SER A 375      10.065   8.052  -6.662  1.00 98.58           C  \\nATOM   2966  O   SER A 375       6.941   8.698  -7.346  1.00 98.58           O  \\nATOM   2967  OG  SER A 375      10.607   9.287  -7.064  1.00 98.58           O  \\nATOM   2968  N   THR A 376       8.263   9.608  -8.914  1.00 98.64           N  \\nATOM   2969  CA  THR A 376       7.288  10.626  -9.340  1.00 98.64           C  \\nATOM   2970  C   THR A 376       6.085   9.982 -10.015  1.00 98.64           C  \\nATOM   2971  CB  THR A 376       7.910  11.668 -10.279  1.00 98.64           C  \\nATOM   2972  O   THR A 376       4.952  10.313  -9.665  1.00 98.64           O  \\nATOM   2973  CG2 THR A 376       6.918  12.742 -10.726  1.00 98.64           C  \\nATOM   2974  OG1 THR A 376       8.946  12.332  -9.601  1.00 98.64           O  \\nATOM   2975  N   ARG A 377       6.304   9.023 -10.925  1.00 98.72           N  \\nATOM   2976  CA  ARG A 377       5.209   8.274 -11.553  1.00 98.72           C  \\nATOM   2977  C   ARG A 377       4.373   7.533 -10.510  1.00 98.72           C  \\nATOM   2978  CB  ARG A 377       5.777   7.311 -12.601  1.00 98.72           C  \\nATOM   2979  O   ARG A 377       3.151   7.622 -10.553  1.00 98.72           O  \\nATOM   2980  CG  ARG A 377       4.652   6.676 -13.438  1.00 98.72           C  \\nATOM   2981  CD  ARG A 377       5.182   5.602 -14.387  1.00 98.72           C  \\nATOM   2982  NE  ARG A 377       5.740   4.459 -13.640  1.00 98.72           N  \\nATOM   2983  NH1 ARG A 377       5.807   2.958 -15.370  1.00 98.72           N  \\nATOM   2984  NH2 ARG A 377       6.399   2.325 -13.327  1.00 98.72           N  \\nATOM   2985  CZ  ARG A 377       5.988   3.260 -14.124  1.00 98.72           C  \\nATOM   2986  N   ALA A 378       5.012   6.871  -9.544  1.00 98.75           N  \\nATOM   2987  CA  ALA A 378       4.325   6.191  -8.445  1.00 98.75           C  \\nATOM   2988  C   ALA A 378       3.463   7.159  -7.611  1.00 98.75           C  \\nATOM   2989  CB  ALA A 378       5.382   5.488  -7.585  1.00 98.75           C  \\nATOM   2990  O   ALA A 378       2.293   6.877  -7.348  1.00 98.75           O  \\nATOM   2991  N   ALA A 379       4.001   8.330  -7.247  1.00 98.78           N  \\nATOM   2992  CA  ALA A 379       3.260   9.357  -6.513  1.00 98.78           C  \\nATOM   2993  C   ALA A 379       2.065   9.897  -7.316  1.00 98.78           C  \\nATOM   2994  CB  ALA A 379       4.230  10.483  -6.130  1.00 98.78           C  \\nATOM   2995  O   ALA A 379       0.981  10.097  -6.764  1.00 98.78           O  \\nATOM   2996  N   HIS A 380       2.242  10.103  -8.622  1.00 98.81           N  \\nATOM   2997  CA  HIS A 380       1.180  10.556  -9.515  1.00 98.81           C  \\nATOM   2998  C   HIS A 380       0.085   9.503  -9.704  1.00 98.81           C  \\nATOM   2999  CB  HIS A 380       1.779  10.962 -10.863  1.00 98.81           C  \\nATOM   3000  O   HIS A 380      -1.090   9.841  -9.561  1.00 98.81           O  \\nATOM   3001  CG  HIS A 380       2.546  12.259 -10.876  1.00 98.81           C  \\nATOM   3002  CD2 HIS A 380       2.715  13.154  -9.850  1.00 98.81           C  \\nATOM   3003  ND1 HIS A 380       3.147  12.803 -11.986  1.00 98.81           N  \\nATOM   3004  CE1 HIS A 380       3.672  13.988 -11.638  1.00 98.81           C  \\nATOM   3005  NE2 HIS A 380       3.424  14.256 -10.344  1.00 98.81           N  \\nATOM   3006  N   MET A 381       0.441   8.237  -9.941  1.00 98.71           N  \\nATOM   3007  CA  MET A 381      -0.532   7.144 -10.011  1.00 98.71           C  \\nATOM   3008  C   MET A 381      -1.320   7.073  -8.705  1.00 98.71           C  \\nATOM   3009  CB  MET A 381       0.153   5.808 -10.351  1.00 98.71           C  \\nATOM   3010  O   MET A 381      -2.526   7.284  -8.731  1.00 98.71           O  \\nATOM   3011  CG  MET A 381       0.622   5.767 -11.812  1.00 98.71           C  \\nATOM   3012  SD  MET A 381      -0.717   5.914 -13.030  1.00 98.71           S  \\nATOM   3013  CE  MET A 381      -1.249   4.191 -13.186  1.00 98.71           C  \\nATOM   3014  N   CYS A 382      -0.641   6.971  -7.556  1.00 98.75           N  \\nATOM   3015  CA  CYS A 382      -1.277   6.977  -6.235  1.00 98.75           C  \\nATOM   3016  C   CYS A 382      -2.235   8.168  -6.037  1.00 98.75           C  \\nATOM   3017  CB  CYS A 382      -0.158   6.984  -5.184  1.00 98.75           C  \\nATOM   3018  O   CYS A 382      -3.330   8.001  -5.497  1.00 98.75           O  \\nATOM   3019  SG  CYS A 382      -0.828   6.691  -3.523  1.00 98.75           S  \\nATOM   3020  N   SER A 383      -1.853   9.367  -6.500  1.00 98.84           N  \\nATOM   3021  CA  SER A 383      -2.701  10.562  -6.416  1.00 98.84           C  \\nATOM   3022  C   SER A 383      -3.982  10.458  -7.241  1.00 98.84           C  \\nATOM   3023  CB  SER A 383      -1.929  11.824  -6.807  1.00 98.84           C  \\nATOM   3024  O   SER A 383      -5.022  10.918  -6.781  1.00 98.84           O  \\nATOM   3025  OG  SER A 383      -1.737  11.972  -8.201  1.00 98.84           O  \\nATOM   3026  N   ALA A 384      -3.928   9.835  -8.422  1.00 98.81           N  \\nATOM   3027  CA  ALA A 384      -5.092   9.650  -9.279  1.00 98.81           C  \\nATOM   3028  C   ALA A 384      -6.100   8.674  -8.658  1.00 98.81           C  \\nATOM   3029  CB  ALA A 384      -4.617   9.192 -10.662  1.00 98.81           C  \\nATOM   3030  O   ALA A 384      -7.302   8.930  -8.709  1.00 98.81           O  \\nATOM   3031  N   GLY A 385      -5.618   7.608  -8.010  1.00 98.76           N  \\nATOM   3032  CA  GLY A 385      -6.468   6.691  -7.244  1.00 98.76           C  \\nATOM   3033  C   GLY A 385      -7.174   7.382  -6.082  1.00 98.76           C  \\nATOM   3034  O   GLY A 385      -8.400   7.330  -5.997  1.00 98.76           O  \\nATOM   3035  N   LEU A 386      -6.427   8.098  -5.226  1.00 98.83           N  \\nATOM   3036  CA  LEU A 386      -7.032   8.837  -4.111  1.00 98.83           C  \\nATOM   3037  C   LEU A 386      -8.006   9.914  -4.606  1.00 98.83           C  \\nATOM   3038  CB  LEU A 386      -5.948   9.452  -3.205  1.00 98.83           C  \\nATOM   3039  O   LEU A 386      -9.088  10.062  -4.044  1.00 98.83           O  \\nATOM   3040  CG  LEU A 386      -6.561  10.303  -2.069  1.00 98.83           C  \\nATOM   3041  CD1 LEU A 386      -7.463   9.489  -1.138  1.00 98.83           C  \\nATOM   3042  CD2 LEU A 386      -5.492  10.997  -1.234  1.00 98.83           C  \\nATOM   3043  N   ALA A 387      -7.654  10.652  -5.659  1.00 98.76           N  \\nATOM   3044  CA  ALA A 387      -8.555  11.638  -6.244  1.00 98.76           C  \\nATOM   3045  C   ALA A 387      -9.857  10.993  -6.743  1.00 98.76           C  \\nATOM   3046  CB  ALA A 387      -7.828  12.376  -7.368  1.00 98.76           C  \\nATOM   3047  O   ALA A 387     -10.919  11.588  -6.592  1.00 98.76           O  \\nATOM   3048  N   GLY A 388      -9.793   9.766  -7.275  1.00 98.53           N  \\nATOM   3049  CA  GLY A 388     -10.974   8.996  -7.663  1.00 98.53           C  \\nATOM   3050  C   GLY A 388     -11.880   8.694  -6.469  1.00 98.53           C  \\nATOM   3051  O   GLY A 388     -13.083   8.936  -6.541  1.00 98.53           O  \\nATOM   3052  N   VAL A 389     -11.294   8.259  -5.349  1.00 98.67           N  \\nATOM   3053  CA  VAL A 389     -12.026   8.021  -4.092  1.00 98.67           C  \\nATOM   3054  C   VAL A 389     -12.666   9.307  -3.567  1.00 98.67           C  \\nATOM   3055  CB  VAL A 389     -11.109   7.382  -3.027  1.00 98.67           C  \\nATOM   3056  O   VAL A 389     -13.866   9.341  -3.315  1.00 98.67           O  \\nATOM   3057  CG1 VAL A 389     -11.791   7.253  -1.659  1.00 98.67           C  \\nATOM   3058  CG2 VAL A 389     -10.669   5.976  -3.451  1.00 98.67           C  \\nATOM   3059  N   ILE A 390     -11.897  10.388  -3.452  1.00 98.50           N  \\nATOM   3060  CA  ILE A 390     -12.374  11.659  -2.890  1.00 98.50           C  \\nATOM   3061  C   ILE A 390     -13.462  12.286  -3.768  1.00 98.50           C  \\nATOM   3062  CB  ILE A 390     -11.170  12.601  -2.669  1.00 98.50           C  \\nATOM   3063  O   ILE A 390     -14.488  12.724  -3.251  1.00 98.50           O  \\nATOM   3064  CG1 ILE A 390     -10.322  12.057  -1.496  1.00 98.50           C  \\nATOM   3065  CG2 ILE A 390     -11.584  14.055  -2.393  1.00 98.50           C  \\nATOM   3066  CD1 ILE A 390      -9.079  12.892  -1.183  1.00 98.50           C  \\nATOM   3067  N   ASN A 391     -13.280  12.312  -5.092  1.00 97.99           N  \\nATOM   3068  CA  ASN A 391     -14.293  12.860  -5.992  1.00 97.99           C  \\nATOM   3069  C   ASN A 391     -15.575  12.021  -5.963  1.00 97.99           C  \\nATOM   3070  CB  ASN A 391     -13.725  13.012  -7.411  1.00 97.99           C  \\nATOM   3071  O   ASN A 391     -16.655  12.603  -5.922  1.00 97.99           O  \\nATOM   3072  CG  ASN A 391     -12.769  14.188  -7.546  1.00 97.99           C  \\nATOM   3073  ND2 ASN A 391     -11.775  14.080  -8.396  1.00 97.99           N  \\nATOM   3074  OD1 ASN A 391     -12.906  15.233  -6.924  1.00 97.99           O  \\nATOM   3075  N   ARG A 392     -15.472  10.685  -5.871  1.00 96.58           N  \\nATOM   3076  CA  ARG A 392     -16.637   9.819  -5.643  1.00 96.58           C  \\nATOM   3077  C   ARG A 392     -17.382  10.204  -4.365  1.00 96.58           C  \\nATOM   3078  CB  ARG A 392     -16.204   8.346  -5.587  1.00 96.58           C  \\nATOM   3079  O   ARG A 392     -18.593  10.376  -4.417  1.00 96.58           O  \\nATOM   3080  CG  ARG A 392     -17.398   7.442  -5.262  1.00 96.58           C  \\nATOM   3081  CD  ARG A 392     -16.968   6.000  -5.001  1.00 96.58           C  \\nATOM   3082  NE  ARG A 392     -18.160   5.151  -4.868  1.00 96.58           N  \\nATOM   3083  NH1 ARG A 392     -18.564   5.064  -7.100  1.00 96.58           N  \\nATOM   3084  NH2 ARG A 392     -20.104   4.293  -5.731  1.00 96.58           N  \\nATOM   3085  CZ  ARG A 392     -18.933   4.825  -5.882  1.00 96.58           C  \\nATOM   3086  N   MET A 393     -16.678  10.328  -3.238  1.00 96.86           N  \\nATOM   3087  CA  MET A 393     -17.297  10.677  -1.952  1.00 96.86           C  \\nATOM   3088  C   MET A 393     -18.008  12.031  -2.019  1.00 96.86           C  \\nATOM   3089  CB  MET A 393     -16.233  10.731  -0.851  1.00 96.86           C  \\nATOM   3090  O   MET A 393     -19.142  12.168  -1.569  1.00 96.86           O  \\nATOM   3091  CG  MET A 393     -15.652   9.361  -0.507  1.00 96.86           C  \\nATOM   3092  SD  MET A 393     -14.265   9.454   0.656  1.00 96.86           S  \\nATOM   3093  CE  MET A 393     -15.188   9.799   2.178  1.00 96.86           C  \\nATOM   3094  N   ARG A 394     -17.366  13.030  -2.632  1.00 96.82           N  \\nATOM   3095  CA  ARG A 394     -17.969  14.349  -2.844  1.00 96.82           C  \\nATOM   3096  C   ARG A 394     -19.245  14.253  -3.686  1.00 96.82           C  \\nATOM   3097  CB  ARG A 394     -16.921  15.259  -3.500  1.00 96.82           C  \\nATOM   3098  O   ARG A 394     -20.254  14.871  -3.355  1.00 96.82           O  \\nATOM   3099  CG  ARG A 394     -17.499  16.644  -3.798  1.00 96.82           C  \\nATOM   3100  CD  ARG A 394     -16.545  17.487  -4.640  1.00 96.82           C  \\nATOM   3101  NE  ARG A 394     -17.291  18.600  -5.247  1.00 96.82           N  \\nATOM   3102  NH1 ARG A 394     -17.548  17.748  -7.372  1.00 96.82           N  \\nATOM   3103  NH2 ARG A 394     -18.596  19.636  -6.760  1.00 96.82           N  \\nATOM   3104  CZ  ARG A 394     -17.800  18.652  -6.461  1.00 96.82           C  \\nATOM   3105  N   GLU A 395     -19.184  13.512  -4.791  1.00 95.18           N  \\nATOM   3106  CA  GLU A 395     -20.299  13.333  -5.724  1.00 95.18           C  \\nATOM   3107  C   GLU A 395     -21.468  12.584  -5.074  1.00 95.18           C  \\nATOM   3108  CB  GLU A 395     -19.805  12.596  -6.984  1.00 95.18           C  \\nATOM   3109  O   GLU A 395     -22.609  13.030  -5.196  1.00 95.18           O  \\nATOM   3110  CG  GLU A 395     -18.950  13.494  -7.899  1.00 95.18           C  \\nATOM   3111  CD  GLU A 395     -18.091  12.723  -8.922  1.00 95.18           C  \\nATOM   3112  OE1 GLU A 395     -17.265  13.389  -9.592  1.00 95.18           O  \\nATOM   3113  OE2 GLU A 395     -18.231  11.487  -9.059  1.00 95.18           O  \\nATOM   3114  N   SER A 396     -21.202  11.506  -4.329  1.00 92.50           N  \\nATOM   3115  CA  SER A 396     -22.244  10.727  -3.647  1.00 92.50           C  \\nATOM   3116  C   SER A 396     -22.952  11.529  -2.554  1.00 92.50           C  \\nATOM   3117  CB  SER A 396     -21.681   9.416  -3.083  1.00 92.50           C  \\nATOM   3118  O   SER A 396     -24.162  11.390  -2.377  1.00 92.50           O  \\nATOM   3119  OG  SER A 396     -20.777   9.613  -2.015  1.00 92.50           O  \\nATOM   3120  N   ARG A 397     -22.230  12.431  -1.881  1.00 93.70           N  \\nATOM   3121  CA  ARG A 397     -22.770  13.331  -0.849  1.00 93.70           C  \\nATOM   3122  C   ARG A 397     -23.376  14.618  -1.398  1.00 93.70           C  \\nATOM   3123  CB  ARG A 397     -21.673  13.633   0.171  1.00 93.70           C  \\nATOM   3124  O   ARG A 397     -23.945  15.395  -0.637  1.00 93.70           O  \\nATOM   3125  CG  ARG A 397     -21.259  12.356   0.904  1.00 93.70           C  \\nATOM   3126  CD  ARG A 397     -20.071  12.671   1.793  1.00 93.70           C  \\nATOM   3127  NE  ARG A 397     -19.587  11.441   2.426  1.00 93.70           N  \\nATOM   3128  NH1 ARG A 397     -17.913  12.459   3.596  1.00 93.70           N  \\nATOM   3129  NH2 ARG A 397     -18.142  10.259   3.718  1.00 93.70           N  \\nATOM   3130  CZ  ARG A 397     -18.555  11.388   3.231  1.00 93.70           C  \\nATOM   3131  N   SER A 398     -23.291  14.844  -2.712  1.00 93.17           N  \\nATOM   3132  CA  SER A 398     -23.761  16.074  -3.365  1.00 93.17           C  \\nATOM   3133  C   SER A 398     -23.169  17.349  -2.744  1.00 93.17           C  \\nATOM   3134  CB  SER A 398     -25.294  16.109  -3.417  1.00 93.17           C  \\nATOM   3135  O   SER A 398     -23.855  18.362  -2.603  1.00 93.17           O  \\nATOM   3136  OG  SER A 398     -25.784  14.977  -4.113  1.00 93.17           O  \\nATOM   3137  N   GLU A 399     -21.892  17.303  -2.360  1.00 92.50           N  \\nATOM   3138  CA  GLU A 399     -21.207  18.432  -1.730  1.00 92.50           C  \\nATOM   3139  C   GLU A 399     -20.519  19.328  -2.770  1.00 92.50           C  \\nATOM   3140  CB  GLU A 399     -20.208  17.947  -0.670  1.00 92.50           C  \\nATOM   3141  O   GLU A 399     -19.718  18.879  -3.596  1.00 92.50           O  \\nATOM   3142  CG  GLU A 399     -20.916  17.390   0.578  1.00 92.50           C  \\nATOM   3143  CD  GLU A 399     -19.939  16.929   1.672  1.00 92.50           C  \\nATOM   3144  OE1 GLU A 399     -20.399  16.285   2.642  1.00 92.50           O  \\nATOM   3145  OE2 GLU A 399     -18.733  17.233   1.553  1.00 92.50           O  \\nATOM   3146  N   ASP A 400     -20.780  20.636  -2.709  1.00 92.82           N  \\nATOM   3147  CA  ASP A 400     -20.091  21.602  -3.570  1.00 92.82           C  \\nATOM   3148  C   ASP A 400     -18.598  21.674  -3.233  1.00 92.82           C  \\nATOM   3149  CB  ASP A 400     -20.731  22.992  -3.445  1.00 92.82           C  \\nATOM   3150  O   ASP A 400     -17.759  21.562  -4.133  1.00 92.82           O  \\nATOM   3151  CG  ASP A 400     -22.056  23.126  -4.198  1.00 92.82           C  \\nATOM   3152  OD1 ASP A 400     -22.203  22.466  -5.251  1.00 92.82           O  \\nATOM   3153  OD2 ASP A 400     -22.873  23.962  -3.752  1.00 92.82           O  \\nATOM   3154  N   VAL A 401     -18.286  21.803  -1.938  1.00 94.77           N  \\nATOM   3155  CA  VAL A 401     -16.934  21.766  -1.370  1.00 94.77           C  \\nATOM   3156  C   VAL A 401     -16.911  20.767  -0.220  1.00 94.77           C  \\nATOM   3157  CB  VAL A 401     -16.463  23.152  -0.882  1.00 94.77           C  \\nATOM   3158  O   VAL A 401     -17.601  20.978   0.776  1.00 94.77           O  \\nATOM   3159  CG1 VAL A 401     -15.048  23.087  -0.285  1.00 94.77           C  \\nATOM   3160  CG2 VAL A 401     -16.439  24.170  -2.030  1.00 94.77           C  \\nATOM   3161  N   MET A 402     -16.094  19.722  -0.345  1.00 96.08           N  \\nATOM   3162  CA  MET A 402     -15.943  18.694   0.689  1.00 96.08           C  \\nATOM   3163  C   MET A 402     -14.693  18.952   1.530  1.00 96.08           C  \\nATOM   3164  CB  MET A 402     -15.939  17.298   0.049  1.00 96.08           C  \\nATOM   3165  O   MET A 402     -13.603  19.158   0.990  1.00 96.08           O  \\nATOM   3166  CG  MET A 402     -15.830  16.175   1.090  1.00 96.08           C  \\nATOM   3167  SD  MET A 402     -16.066  14.506   0.424  1.00 96.08           S  \\nATOM   3168  CE  MET A 402     -14.486  14.324  -0.423  1.00 96.08           C  \\nATOM   3169  N   ARG A 403     -14.841  18.915   2.855  1.00 97.26           N  \\nATOM   3170  CA  ARG A 403     -13.721  18.904   3.805  1.00 97.26           C  \\nATOM   3171  C   ARG A 403     -13.480  17.480   4.249  1.00 97.26           C  \\nATOM   3172  CB  ARG A 403     -14.018  19.781   5.022  1.00 97.26           C  \\nATOM   3173  O   ARG A 403     -14.407  16.822   4.703  1.00 97.26           O  \\nATOM   3174  CG  ARG A 403     -13.972  21.250   4.627  1.00 97.26           C  \\nATOM   3175  CD  ARG A 403     -14.235  22.142   5.829  1.00 97.26           C  \\nATOM   3176  NE  ARG A 403     -13.964  23.523   5.437  1.00 97.26           N  \\nATOM   3177  NH1 ARG A 403     -14.837  24.611   7.240  1.00 97.26           N  \\nATOM   3178  NH2 ARG A 403     -13.980  25.755   5.491  1.00 97.26           N  \\nATOM   3179  CZ  ARG A 403     -14.271  24.626   6.064  1.00 97.26           C  \\nATOM   3180  N   ILE A 404     -12.250  17.008   4.106  1.00 97.41           N  \\nATOM   3181  CA  ILE A 404     -11.933  15.626   4.440  1.00 97.41           C  \\nATOM   3182  C   ILE A 404     -10.504  15.487   4.934  1.00 97.41           C  \\nATOM   3183  CB  ILE A 404     -12.247  14.708   3.239  1.00 97.41           C  \\nATOM   3184  O   ILE A 404      -9.586  16.166   4.465  1.00 97.41           O  \\nATOM   3185  CG1 ILE A 404     -12.286  13.236   3.690  1.00 97.41           C  \\nATOM   3186  CG2 ILE A 404     -11.278  14.926   2.060  1.00 97.41           C  \\nATOM   3187  CD1 ILE A 404     -12.971  12.330   2.668  1.00 97.41           C  \\nATOM   3188  N   THR A 405     -10.319  14.548   5.851  1.00 98.13           N  \\nATOM   3189  CA  THR A 405      -9.004  14.127   6.307  1.00 98.13           C  \\nATOM   3190  C   THR A 405      -8.695  12.723   5.795  1.00 98.13           C  \\nATOM   3191  CB  THR A 405      -8.869  14.311   7.822  1.00 98.13           C  \\nATOM   3192  O   THR A 405      -9.552  11.838   5.757  1.00 98.13           O  \\nATOM   3193  CG2 THR A 405      -7.534  13.815   8.359  1.00 98.13           C  \\nATOM   3194  OG1 THR A 405      -8.946  15.690   8.085  1.00 98.13           O  \\nATOM   3195  N   VAL A 406      -7.450  12.526   5.371  1.00 98.51           N  \\nATOM   3196  CA  VAL A 406      -6.920  11.247   4.902  1.00 98.51           C  \\nATOM   3197  C   VAL A 406      -5.826  10.803   5.865  1.00 98.51           C  \\nATOM   3198  CB  VAL A 406      -6.395  11.356   3.459  1.00 98.51           C  \\nATOM   3199  O   VAL A 406      -4.773  11.442   5.959  1.00 98.51           O  \\nATOM   3200  CG1 VAL A 406      -5.929   9.990   2.944  1.00 98.51           C  \\nATOM   3201  CG2 VAL A 406      -7.447  11.900   2.483  1.00 98.51           C  \\nATOM   3202  N   GLY A 407      -6.071   9.704   6.570  1.00 97.72           N  \\nATOM   3203  CA  GLY A 407      -5.066   9.021   7.375  1.00 97.72           C  \\nATOM   3204  C   GLY A 407      -4.169   8.178   6.476  1.00 97.72           C  \\nATOM   3205  O   GLY A 407      -4.665   7.344   5.721  1.00 97.72           O  \\nATOM   3206  N   VAL A 408      -2.854   8.381   6.537  1.00 97.79           N  \\nATOM   3207  CA  VAL A 408      -1.888   7.671   5.691  1.00 97.79           C  \\nATOM   3208  C   VAL A 408      -0.822   6.994   6.545  1.00 97.79           C  \\nATOM   3209  CB  VAL A 408      -1.241   8.587   4.632  1.00 97.79           C  \\nATOM   3210  O   VAL A 408      -0.188   7.622   7.394  1.00 97.79           O  \\nATOM   3211  CG1 VAL A 408      -0.512   7.741   3.576  1.00 97.79           C  \\nATOM   3212  CG2 VAL A 408      -2.245   9.474   3.882  1.00 97.79           C  \\nATOM   3213  N   ASP A 409      -0.585   5.714   6.284  1.00 95.43           N  \\nATOM   3214  CA  ASP A 409       0.547   4.948   6.805  1.00 95.43           C  \\nATOM   3215  C   ASP A 409       1.335   4.315   5.640  1.00 95.43           C  \\nATOM   3216  CB  ASP A 409       0.046   3.919   7.844  1.00 95.43           C  \\nATOM   3217  O   ASP A 409       0.920   4.346   4.482  1.00 95.43           O  \\nATOM   3218  CG  ASP A 409       1.108   3.476   8.863  1.00 95.43           C  \\nATOM   3219  OD1 ASP A 409       2.321   3.682   8.613  1.00 95.43           O  \\nATOM   3220  OD2 ASP A 409       0.739   2.972   9.941  1.00 95.43           O  \\nATOM   3221  N   GLY A 410       2.493   3.736   5.934  1.00 93.71           N  \\nATOM   3222  CA  GLY A 410       3.334   3.016   4.993  1.00 93.71           C  \\nATOM   3223  C   GLY A 410       4.702   3.662   4.785  1.00 93.71           C  \\nATOM   3224  O   GLY A 410       4.882   4.880   4.794  1.00 93.71           O  \\nATOM   3225  N   SER A 411       5.705   2.807   4.600  1.00 93.45           N  \\nATOM   3226  CA  SER A 411       7.112   3.201   4.516  1.00 93.45           C  \\nATOM   3227  C   SER A 411       7.436   4.118   3.336  1.00 93.45           C  \\nATOM   3228  CB  SER A 411       7.984   1.944   4.439  1.00 93.45           C  \\nATOM   3229  O   SER A 411       8.307   4.970   3.476  1.00 93.45           O  \\nATOM   3230  OG  SER A 411       7.527   1.082   3.409  1.00 93.45           O  \\nATOM   3231  N   VAL A 412       6.754   3.991   2.193  1.00 96.83           N  \\nATOM   3232  CA  VAL A 412       6.999   4.862   1.032  1.00 96.83           C  \\nATOM   3233  C   VAL A 412       6.534   6.280   1.343  1.00 96.83           C  \\nATOM   3234  CB  VAL A 412       6.334   4.312  -0.243  1.00 96.83           C  \\nATOM   3235  O   VAL A 412       7.294   7.222   1.145  1.00 96.83           O  \\nATOM   3236  CG1 VAL A 412       6.449   5.272  -1.432  1.00 96.83           C  \\nATOM   3237  CG2 VAL A 412       6.963   2.976  -0.651  1.00 96.83           C  \\nATOM   3238  N   TYR A 413       5.335   6.442   1.904  1.00 97.55           N  \\nATOM   3239  CA  TYR A 413       4.828   7.761   2.284  1.00 97.55           C  \\nATOM   3240  C   TYR A 413       5.661   8.428   3.385  1.00 97.55           C  \\nATOM   3241  CB  TYR A 413       3.374   7.617   2.724  1.00 97.55           C  \\nATOM   3242  O   TYR A 413       5.941   9.623   3.301  1.00 97.55           O  \\nATOM   3243  CG  TYR A 413       2.723   8.918   3.123  1.00 97.55           C  \\nATOM   3244  CD1 TYR A 413       2.639   9.280   4.481  1.00 97.55           C  \\nATOM   3245  CD2 TYR A 413       2.170   9.746   2.129  1.00 97.55           C  \\nATOM   3246  CE1 TYR A 413       1.964  10.454   4.853  1.00 97.55           C  \\nATOM   3247  CE2 TYR A 413       1.496  10.923   2.498  1.00 97.55           C  \\nATOM   3248  OH  TYR A 413       0.665  12.364   4.220  1.00 97.55           O  \\nATOM   3249  CZ  TYR A 413       1.376  11.265   3.860  1.00 97.55           C  \\nATOM   3250  N   LYS A 414       6.064   7.655   4.399  1.00 95.52           N  \\nATOM   3251  CA  LYS A 414       6.765   8.170   5.584  1.00 95.52           C  \\nATOM   3252  C   LYS A 414       8.254   8.423   5.366  1.00 95.52           C  \\nATOM   3253  CB  LYS A 414       6.575   7.187   6.744  1.00 95.52           C  \\nATOM   3254  O   LYS A 414       8.808   9.358   5.932  1.00 95.52           O  \\nATOM   3255  CG  LYS A 414       5.117   7.124   7.211  1.00 95.52           C  \\nATOM   3256  CD  LYS A 414       4.999   6.190   8.415  1.00 95.52           C  \\nATOM   3257  CE  LYS A 414       3.686   6.452   9.140  1.00 95.52           C  \\nATOM   3258  NZ  LYS A 414       3.470   5.453  10.201  1.00 95.52           N  \\nATOM   3259  N   LEU A 415       8.925   7.561   4.598  1.00 95.41           N  \\nATOM   3260  CA  LEU A 415      10.392   7.518   4.546  1.00 95.41           C  \\nATOM   3261  C   LEU A 415      10.977   7.985   3.209  1.00 95.41           C  \\nATOM   3262  CB  LEU A 415      10.902   6.103   4.889  1.00 95.41           C  \\nATOM   3263  O   LEU A 415      12.178   8.243   3.141  1.00 95.41           O  \\nATOM   3264  CG  LEU A 415      10.332   5.469   6.173  1.00 95.41           C  \\nATOM   3265  CD1 LEU A 415      10.907   4.061   6.340  1.00 95.41           C  \\nATOM   3266  CD2 LEU A 415      10.676   6.279   7.423  1.00 95.41           C  \\nATOM   3267  N   HIS A 416      10.185   8.069   2.134  1.00 97.67           N  \\nATOM   3268  CA  HIS A 416      10.684   8.593   0.863  1.00 97.67           C  \\nATOM   3269  C   HIS A 416      10.718  10.131   0.896  1.00 97.67           C  \\nATOM   3270  CB  HIS A 416       9.844   8.070  -0.302  1.00 97.67           C  \\nATOM   3271  O   HIS A 416       9.685  10.749   1.166  1.00 97.67           O  \\nATOM   3272  CG  HIS A 416      10.497   8.301  -1.637  1.00 97.67           C  \\nATOM   3273  CD2 HIS A 416      11.195   7.367  -2.353  1.00 97.67           C  \\nATOM   3274  ND1 HIS A 416      10.537   9.476  -2.360  1.00 97.67           N  \\nATOM   3275  CE1 HIS A 416      11.237   9.248  -3.481  1.00 97.67           C  \\nATOM   3276  NE2 HIS A 416      11.662   7.980  -3.512  1.00 97.67           N  \\nATOM   3277  N   PRO A 417      11.852  10.780   0.567  1.00 97.21           N  \\nATOM   3278  CA  PRO A 417      12.072  12.207   0.840  1.00 97.21           C  \\nATOM   3279  C   PRO A 417      11.101  13.146   0.110  1.00 97.21           C  \\nATOM   3280  CB  PRO A 417      13.519  12.470   0.396  1.00 97.21           C  \\nATOM   3281  O   PRO A 417      10.757  14.207   0.617  1.00 97.21           O  \\nATOM   3282  CG  PRO A 417      13.776  11.387  -0.652  1.00 97.21           C  \\nATOM   3283  CD  PRO A 417      13.038  10.200  -0.049  1.00 97.21           C  \\nATOM   3284  N   SER A 418      10.667  12.760  -1.088  1.00 96.74           N  \\nATOM   3285  CA  SER A 418       9.920  13.611  -2.023  1.00 96.74           C  \\nATOM   3286  C   SER A 418       8.529  13.069  -2.378  1.00 96.74           C  \\nATOM   3287  CB  SER A 418      10.769  13.723  -3.292  1.00 96.74           C  \\nATOM   3288  O   SER A 418       7.746  13.759  -3.032  1.00 96.74           O  \\nATOM   3289  OG  SER A 418      10.969  12.401  -3.768  1.00 96.74           O  \\nATOM   3290  N   PHE A 419       8.195  11.835  -1.969  1.00 98.45           N  \\nATOM   3291  CA  PHE A 419       6.973  11.162  -2.431  1.00 98.45           C  \\nATOM   3292  C   PHE A 419       5.731  11.884  -1.910  1.00 98.45           C  \\nATOM   3293  CB  PHE A 419       6.971   9.689  -1.999  1.00 98.45           C  \\nATOM   3294  O   PHE A 419       4.843  12.224  -2.687  1.00 98.45           O  \\nATOM   3295  CG  PHE A 419       5.789   8.892  -2.515  1.00 98.45           C  \\nATOM   3296  CD1 PHE A 419       4.542   8.963  -1.862  1.00 98.45           C  \\nATOM   3297  CD2 PHE A 419       5.934   8.071  -3.650  1.00 98.45           C  \\nATOM   3298  CE1 PHE A 419       3.441   8.247  -2.360  1.00 98.45           C  \\nATOM   3299  CE2 PHE A 419       4.841   7.324  -4.122  1.00 98.45           C  \\nATOM   3300  CZ  PHE A 419       3.593   7.417  -3.483  1.00 98.45           C  \\nATOM   3301  N   LYS A 420       5.707  12.169  -0.602  1.00 97.84           N  \\nATOM   3302  CA  LYS A 420       4.611  12.854   0.096  1.00 97.84           C  \\nATOM   3303  C   LYS A 420       4.275  14.202  -0.544  1.00 97.84           C  \\nATOM   3304  CB  LYS A 420       5.014  12.974   1.576  1.00 97.84           C  \\nATOM   3305  O   LYS A 420       3.113  14.464  -0.836  1.00 97.84           O  \\nATOM   3306  CG  LYS A 420       3.972  13.642   2.491  1.00 97.84           C  \\nATOM   3307  CD  LYS A 420       4.410  13.453   3.956  1.00 97.84           C  \\nATOM   3308  CE  LYS A 420       3.440  14.045   4.988  1.00 97.84           C  \\nATOM   3309  NZ  LYS A 420       3.849  13.687   6.381  1.00 97.84           N  \\nATOM   3310  N   GLU A 421       5.288  15.017  -0.837  1.00 98.17           N  \\nATOM   3311  CA  GLU A 421       5.108  16.328  -1.472  1.00 98.17           C  \\nATOM   3312  C   GLU A 421       4.501  16.207  -2.879  1.00 98.17           C  \\nATOM   3313  CB  GLU A 421       6.461  17.053  -1.515  1.00 98.17           C  \\nATOM   3314  O   GLU A 421       3.492  16.852  -3.176  1.00 98.17           O  \\nATOM   3315  CG  GLU A 421       6.326  18.489  -2.046  1.00 98.17           C  \\nATOM   3316  CD  GLU A 421       7.673  19.208  -2.216  1.00 98.17           C  \\nATOM   3317  OE1 GLU A 421       7.643  20.326  -2.776  1.00 98.17           O  \\nATOM   3318  OE2 GLU A 421       8.712  18.637  -1.816  1.00 98.17           O  \\nATOM   3319  N   ARG A 422       5.074  15.343  -3.731  1.00 98.35           N  \\nATOM   3320  CA  ARG A 422       4.594  15.114  -5.107  1.00 98.35           C  \\nATOM   3321  C   ARG A 422       3.166  14.567  -5.117  1.00 98.35           C  \\nATOM   3322  CB  ARG A 422       5.549  14.153  -5.838  1.00 98.35           C  \\nATOM   3323  O   ARG A 422       2.323  15.048  -5.876  1.00 98.35           O  \\nATOM   3324  CG  ARG A 422       6.938  14.762  -6.102  1.00 98.35           C  \\nATOM   3325  CD  ARG A 422       7.885  13.697  -6.675  1.00 98.35           C  \\nATOM   3326  NE  ARG A 422       9.277  14.183  -6.792  1.00 98.35           N  \\nATOM   3327  NH1 ARG A 422      10.319  12.124  -6.780  1.00 98.35           N  \\nATOM   3328  NH2 ARG A 422      11.558  13.921  -6.686  1.00 98.35           N  \\nATOM   3329  CZ  ARG A 422      10.361  13.419  -6.768  1.00 98.35           C  \\nATOM   3330  N   PHE A 423       2.888  13.609  -4.234  1.00 98.65           N  \\nATOM   3331  CA  PHE A 423       1.570  13.018  -4.036  1.00 98.65           C  \\nATOM   3332  C   PHE A 423       0.542  14.083  -3.630  1.00 98.65           C  \\nATOM   3333  CB  PHE A 423       1.695  11.889  -3.005  1.00 98.65           C  \\nATOM   3334  O   PHE A 423      -0.445  14.268  -4.338  1.00 98.65           O  \\nATOM   3335  CG  PHE A 423       0.376  11.341  -2.507  1.00 98.65           C  \\nATOM   3336  CD1 PHE A 423       0.013  11.522  -1.161  1.00 98.65           C  \\nATOM   3337  CD2 PHE A 423      -0.484  10.649  -3.379  1.00 98.65           C  \\nATOM   3338  CE1 PHE A 423      -1.208  11.017  -0.684  1.00 98.65           C  \\nATOM   3339  CE2 PHE A 423      -1.702  10.137  -2.899  1.00 98.65           C  \\nATOM   3340  CZ  PHE A 423      -2.057  10.315  -1.553  1.00 98.65           C  \\nATOM   3341  N   HIS A 424       0.797  14.858  -2.568  1.00 98.52           N  \\nATOM   3342  CA  HIS A 424      -0.119  15.910  -2.103  1.00 98.52           C  \\nATOM   3343  C   HIS A 424      -0.375  16.977  -3.166  1.00 98.52           C  \\nATOM   3344  CB  HIS A 424       0.456  16.605  -0.860  1.00 98.52           C  \\nATOM   3345  O   HIS A 424      -1.518  17.389  -3.368  1.00 98.52           O  \\nATOM   3346  CG  HIS A 424       0.505  15.794   0.405  1.00 98.52           C  \\nATOM   3347  CD2 HIS A 424       0.042  14.524   0.588  1.00 98.52           C  \\nATOM   3348  ND1 HIS A 424       0.957  16.295   1.626  1.00 98.52           N  \\nATOM   3349  CE1 HIS A 424       0.778  15.303   2.510  1.00 98.52           C  \\nATOM   3350  NE2 HIS A 424       0.245  14.225   1.915  1.00 98.52           N  \\nATOM   3351  N   ALA A 425       0.675  17.437  -3.851  1.00 98.29           N  \\nATOM   3352  CA  ALA A 425       0.545  18.443  -4.899  1.00 98.29           C  \\nATOM   3353  C   ALA A 425      -0.334  17.947  -6.055  1.00 98.29           C  \\nATOM   3354  CB  ALA A 425       1.947  18.827  -5.383  1.00 98.29           C  \\nATOM   3355  O   ALA A 425      -1.141  18.712  -6.580  1.00 98.29           O  \\nATOM   3356  N   SER A 426      -0.192  16.677  -6.439  1.00 98.47           N  \\nATOM   3357  CA  SER A 426      -0.983  16.079  -7.511  1.00 98.47           C  \\nATOM   3358  C   SER A 426      -2.439  15.839  -7.109  1.00 98.47           C  \\nATOM   3359  CB  SER A 426      -0.292  14.808  -7.995  1.00 98.47           C  \\nATOM   3360  O   SER A 426      -3.331  16.214  -7.866  1.00 98.47           O  \\nATOM   3361  OG  SER A 426      -0.895  14.375  -9.190  1.00 98.47           O  \\nATOM   3362  N   VAL A 427      -2.700  15.342  -5.891  1.00 98.58           N  \\nATOM   3363  CA  VAL A 427      -4.074  15.172  -5.379  1.00 98.58           C  \\nATOM   3364  C   VAL A 427      -4.827  16.502  -5.422  1.00 98.58           C  \\nATOM   3365  CB  VAL A 427      -4.090  14.592  -3.951  1.00 98.58           C  \\nATOM   3366  O   VAL A 427      -5.896  16.573  -6.017  1.00 98.58           O  \\nATOM   3367  CG1 VAL A 427      -5.510  14.535  -3.378  1.00 98.58           C  \\nATOM   3368  CG2 VAL A 427      -3.548  13.161  -3.906  1.00 98.58           C  \\nATOM   3369  N   ARG A 428      -4.232  17.587  -4.902  1.00 97.99           N  \\nATOM   3370  CA  ARG A 428      -4.873  18.916  -4.877  1.00 97.99           C  \\nATOM   3371  C   ARG A 428      -5.260  19.436  -6.265  1.00 97.99           C  \\nATOM   3372  CB  ARG A 428      -3.957  19.935  -4.188  1.00 97.99           C  \\nATOM   3373  O   ARG A 428      -6.267  20.124  -6.386  1.00 97.99           O  \\nATOM   3374  CG  ARG A 428      -3.847  19.702  -2.676  1.00 97.99           C  \\nATOM   3375  CD  ARG A 428      -2.901  20.743  -2.067  1.00 97.99           C  \\nATOM   3376  NE  ARG A 428      -2.589  20.428  -0.660  1.00 97.99           N  \\nATOM   3377  NH1 ARG A 428      -0.290  20.333  -0.817  1.00 97.99           N  \\nATOM   3378  NH2 ARG A 428      -1.291  19.869   1.120  1.00 97.99           N  \\nATOM   3379  CZ  ARG A 428      -1.395  20.218  -0.131  1.00 97.99           C  \\nATOM   3380  N   ARG A 429      -4.484  19.120  -7.309  1.00 97.99           N  \\nATOM   3381  CA  ARG A 429      -4.830  19.494  -8.695  1.00 97.99           C  \\nATOM   3382  C   ARG A 429      -6.012  18.688  -9.236  1.00 97.99           C  \\nATOM   3383  CB  ARG A 429      -3.623  19.324  -9.628  1.00 97.99           C  \\nATOM   3384  O   ARG A 429      -6.802  19.220 -10.007  1.00 97.99           O  \\nATOM   3385  CG  ARG A 429      -2.515  20.355  -9.371  1.00 97.99           C  \\nATOM   3386  CD  ARG A 429      -1.435  20.292 -10.460  1.00 97.99           C  \\nATOM   3387  NE  ARG A 429      -0.795  18.963 -10.559  1.00 97.99           N  \\nATOM   3388  NH1 ARG A 429       0.907  19.262  -9.046  1.00 97.99           N  \\nATOM   3389  NH2 ARG A 429       0.760  17.341 -10.170  1.00 97.99           N  \\nATOM   3390  CZ  ARG A 429       0.284  18.532  -9.929  1.00 97.99           C  \\nATOM   3391  N   LEU A 430      -6.130  17.423  -8.837  1.00 98.58           N  \\nATOM   3392  CA  LEU A 430      -7.182  16.509  -9.292  1.00 98.58           C  \\nATOM   3393  C   LEU A 430      -8.491  16.639  -8.492  1.00 98.58           C  \\nATOM   3394  CB  LEU A 430      -6.631  15.073  -9.252  1.00 98.58           C  \\nATOM   3395  O   LEU A 430      -9.535  16.182  -8.957  1.00 98.58           O  \\nATOM   3396  CG  LEU A 430      -5.439  14.806 -10.190  1.00 98.58           C  \\nATOM   3397  CD1 LEU A 430      -4.883  13.409  -9.921  1.00 98.58           C  \\nATOM   3398  CD2 LEU A 430      -5.830  14.895 -11.668  1.00 98.58           C  \\nATOM   3399  N   THR A 431      -8.458  17.288  -7.325  1.00 98.02           N  \\nATOM   3400  CA  THR A 431      -9.617  17.496  -6.438  1.00 98.02           C  \\nATOM   3401  C   THR A 431      -9.827  18.985  -6.095  1.00 98.02           C  \\nATOM   3402  CB  THR A 431      -9.473  16.649  -5.161  1.00 98.02           C  \\nATOM   3403  O   THR A 431      -9.805  19.354  -4.918  1.00 98.02           O  \\nATOM   3404  CG2 THR A 431      -9.295  15.157  -5.430  1.00 98.02           C  \\nATOM   3405  OG1 THR A 431      -8.355  17.099  -4.429  1.00 98.02           O  \\nATOM   3406  N   PRO A 432     -10.027  19.886  -7.079  1.00 96.88           N  \\nATOM   3407  CA  PRO A 432     -10.092  21.336  -6.839  1.00 96.88           C  \\nATOM   3408  C   PRO A 432     -11.274  21.777  -5.957  1.00 96.88           C  \\nATOM   3409  CB  PRO A 432     -10.185  21.961  -8.235  1.00 96.88           C  \\nATOM   3410  O   PRO A 432     -11.250  22.870  -5.398  1.00 96.88           O  \\nATOM   3411  CG  PRO A 432     -10.848  20.868  -9.073  1.00 96.88           C  \\nATOM   3412  CD  PRO A 432     -10.242  19.595  -8.489  1.00 96.88           C  \\nATOM   3413  N   SER A 433     -12.298  20.933  -5.828  1.00 96.98           N  \\nATOM   3414  CA  SER A 433     -13.488  21.160  -4.999  1.00 96.98           C  \\nATOM   3415  C   SER A 433     -13.397  20.494  -3.620  1.00 96.98           C  \\nATOM   3416  CB  SER A 433     -14.734  20.685  -5.753  1.00 96.98           C  \\nATOM   3417  O   SER A 433     -14.423  20.276  -2.983  1.00 96.98           O  \\nATOM   3418  OG  SER A 433     -14.870  21.380  -6.980  1.00 96.98           O  \\nATOM   3419  N   CYS A 434     -12.200  20.110  -3.167  1.00 97.41           N  \\nATOM   3420  CA  CYS A 434     -12.003  19.455  -1.874  1.00 97.41           C  \\nATOM   3421  C   CYS A 434     -10.891  20.134  -1.065  1.00 97.41           C  \\nATOM   3422  CB  CYS A 434     -11.706  17.962  -2.076  1.00 97.41           C  \\nATOM   3423  O   CYS A 434      -9.795  20.383  -1.569  1.00 97.41           O  \\nATOM   3424  SG  CYS A 434     -13.060  17.145  -2.970  1.00 97.41           S  \\nATOM   3425  N   GLU A 435     -11.153  20.377   0.216  1.00 97.22           N  \\nATOM   3426  CA  GLU A 435     -10.158  20.795   1.202  1.00 97.22           C  \\nATOM   3427  C   GLU A 435      -9.650  19.543   1.931  1.00 97.22           C  \\nATOM   3428  CB  GLU A 435     -10.769  21.809   2.181  1.00 97.22           C  \\nATOM   3429  O   GLU A 435     -10.371  18.948   2.732  1.00 97.22           O  \\nATOM   3430  CG  GLU A 435     -11.081  23.181   1.555  1.00 97.22           C  \\nATOM   3431  CD  GLU A 435     -11.714  24.185   2.545  1.00 97.22           C  \\nATOM   3432  OE1 GLU A 435     -12.108  25.291   2.115  1.00 97.22           O  \\nATOM   3433  OE2 GLU A 435     -11.842  23.891   3.756  1.00 97.22           O  \\nATOM   3434  N   ILE A 436      -8.420  19.123   1.616  1.00 98.10           N  \\nATOM   3435  CA  ILE A 436      -7.862  17.846   2.082  1.00 98.10           C  \\nATOM   3436  C   ILE A 436      -6.751  18.077   3.105  1.00 98.10           C  \\nATOM   3437  CB  ILE A 436      -7.371  16.966   0.913  1.00 98.10           C  \\nATOM   3438  O   ILE A 436      -5.720  18.687   2.791  1.00 98.10           O  \\nATOM   3439  CG1 ILE A 436      -8.491  16.740  -0.127  1.00 98.10           C  \\nATOM   3440  CG2 ILE A 436      -6.879  15.607   1.458  1.00 98.10           C  \\nATOM   3441  CD1 ILE A 436      -7.964  16.184  -1.448  1.00 98.10           C  \\nATOM   3442  N   THR A 437      -6.931  17.498   4.288  1.00 98.17           N  \\nATOM   3443  CA  THR A 437      -5.894  17.369   5.317  1.00 98.17           C  \\nATOM   3444  C   THR A 437      -5.314  15.957   5.280  1.00 98.17           C  \\nATOM   3445  CB  THR A 437      -6.462  17.704   6.700  1.00 98.17           C  \\nATOM   3446  O   THR A 437      -6.042  14.978   5.155  1.00 98.17           O  \\nATOM   3447  CG2 THR A 437      -5.429  17.603   7.823  1.00 98.17           C  \\nATOM   3448  OG1 THR A 437      -6.920  19.035   6.703  1.00 98.17           O  \\nATOM   3449  N   PHE A 438      -3.994  15.826   5.395  1.00 98.15           N  \\nATOM   3450  CA  PHE A 438      -3.334  14.523   5.492  1.00 98.15           C  \\nATOM   3451  C   PHE A 438      -2.746  14.347   6.886  1.00 98.15           C  \\nATOM   3452  CB  PHE A 438      -2.246  14.387   4.426  1.00 98.15           C  \\nATOM   3453  O   PHE A 438      -1.930  15.169   7.306  1.00 98.15           O  \\nATOM   3454  CG  PHE A 438      -2.765  14.311   3.007  1.00 98.15           C  \\nATOM   3455  CD1 PHE A 438      -3.146  13.068   2.472  1.00 98.15           C  \\nATOM   3456  CD2 PHE A 438      -2.851  15.471   2.214  1.00 98.15           C  \\nATOM   3457  CE1 PHE A 438      -3.602  12.983   1.148  1.00 98.15           C  \\nATOM   3458  CE2 PHE A 438      -3.306  15.385   0.886  1.00 98.15           C  \\nATOM   3459  CZ  PHE A 438      -3.677  14.139   0.352  1.00 98.15           C  \\nATOM   3460  N   ILE A 439      -3.106  13.256   7.557  1.00 95.95           N  \\nATOM   3461  CA  ILE A 439      -2.537  12.869   8.850  1.00 95.95           C  \\nATOM   3462  C   ILE A 439      -1.671  11.637   8.637  1.00 95.95           C  \\nATOM   3463  CB  ILE A 439      -3.628  12.671   9.924  1.00 95.95           C  \\nATOM   3464  O   ILE A 439      -2.076  10.665   8.004  1.00 95.95           O  \\nATOM   3465  CG1 ILE A 439      -4.355  14.016  10.145  1.00 95.95           C  \\nATOM   3466  CG2 ILE A 439      -3.009  12.162  11.241  1.00 95.95           C  \\nATOM   3467  CD1 ILE A 439      -5.454  13.967  11.209  1.00 95.95           C  \\nATOM   3468  N   GLU A 440      -0.445  11.694   9.137  1.00 95.20           N  \\nATOM   3469  CA  GLU A 440       0.439  10.539   9.153  1.00 95.20           C  \\nATOM   3470  C   GLU A 440       0.131   9.697  10.389  1.00 95.20           C  \\nATOM   3471  CB  GLU A 440       1.880  11.037   9.109  1.00 95.20           C  \\nATOM   3472  O   GLU A 440       0.173  10.201  11.505  1.00 95.20           O  \\nATOM   3473  CG  GLU A 440       2.869   9.885   8.947  1.00 95.20           C  \\nATOM   3474  CD  GLU A 440       4.284  10.413   8.696  1.00 95.20           C  \\nATOM   3475  OE1 GLU A 440       5.218   9.811   9.268  1.00 95.20           O  \\nATOM   3476  OE2 GLU A 440       4.415  11.358   7.865  1.00 95.20           O  \\nATOM   3477  N   SER A 441      -0.213   8.428  10.194  1.00 90.21           N  \\nATOM   3478  CA  SER A 441      -0.672   7.577  11.290  1.00 90.21           C  \\nATOM   3479  C   SER A 441       0.495   7.055  12.127  1.00 90.21           C  \\nATOM   3480  CB  SER A 441      -1.475   6.420  10.707  1.00 90.21           C  \\nATOM   3481  O   SER A 441       1.377   6.383  11.594  1.00 90.21           O  \\nATOM   3482  OG  SER A 441      -2.319   5.886  11.696  1.00 90.21           O  \\nATOM   3483  N   GLU A 442       0.517   7.298  13.436  1.00 83.01           N  \\nATOM   3484  CA  GLU A 442       1.490   6.680  14.345  1.00 83.01           C  \\nATOM   3485  C   GLU A 442       0.958   5.336  14.864  1.00 83.01           C  \\nATOM   3486  CB  GLU A 442       1.862   7.624  15.495  1.00 83.01           C  \\nATOM   3487  O   GLU A 442      -0.054   5.276  15.557  1.00 83.01           O  \\nATOM   3488  CG  GLU A 442       2.634   8.860  15.001  1.00 83.01           C  \\nATOM   3489  CD  GLU A 442       3.233   9.702  16.142  1.00 83.01           C  \\nATOM   3490  OE1 GLU A 442       3.965  10.665  15.817  1.00 83.01           O  \\nATOM   3491  OE2 GLU A 442       3.025   9.349  17.326  1.00 83.01           O  \\nATOM   3492  N   GLU A 443       1.633   4.235  14.510  1.00 77.64           N  \\nATOM   3493  CA  GLU A 443       1.215   2.866  14.862  1.00 77.64           C  \\nATOM   3494  C   GLU A 443      -0.220   2.497  14.416  1.00 77.64           C  \\nATOM   3495  CB  GLU A 443       1.459   2.564  16.358  1.00 77.64           C  \\nATOM   3496  O   GLU A 443      -0.873   1.650  15.036  1.00 77.64           O  \\nATOM   3497  CG  GLU A 443       2.886   2.866  16.842  1.00 77.64           C  \\nATOM   3498  CD  GLU A 443       3.132   2.449  18.306  1.00 77.64           C  \\nATOM   3499  OE1 GLU A 443       4.315   2.248  18.652  1.00 77.64           O  \\nATOM   3500  OE2 GLU A 443       2.170   2.219  19.077  1.00 77.64           O  \\nATOM   3501  N   GLY A 444      -0.684   3.095  13.312  1.00 80.51           N  \\nATOM   3502  CA  GLY A 444      -2.086   3.126  12.892  1.00 80.51           C  \\nATOM   3503  C   GLY A 444      -2.797   1.784  12.849  1.00 80.51           C  \\nATOM   3504  O   GLY A 444      -3.886   1.643  13.401  1.00 80.51           O  \\nATOM   3505  N   SER A 445      -2.167   0.773  12.251  1.00 84.98           N  \\nATOM   3506  CA  SER A 445      -2.765  -0.558  12.108  1.00 84.98           C  \\nATOM   3507  C   SER A 445      -3.056  -1.238  13.450  1.00 84.98           C  \\nATOM   3508  CB  SER A 445      -1.884  -1.455  11.235  1.00 84.98           C  \\nATOM   3509  O   SER A 445      -4.115  -1.835  13.626  1.00 84.98           O  \\nATOM   3510  OG  SER A 445      -0.534  -1.336  11.609  1.00 84.98           O  \\nATOM   3511  N   GLY A 446      -2.156  -1.139  14.428  1.00 87.43           N  \\nATOM   3512  CA  GLY A 446      -2.364  -1.760  15.735  1.00 87.43           C  \\nATOM   3513  C   GLY A 446      -3.289  -0.949  16.641  1.00 87.43           C  \\nATOM   3514  O   GLY A 446      -4.148  -1.522  17.317  1.00 87.43           O  \\nATOM   3515  N   ARG A 447      -3.155   0.382  16.641  1.00 89.93           N  \\nATOM   3516  CA  ARG A 447      -4.031   1.277  17.411  1.00 89.93           C  \\nATOM   3517  C   ARG A 447      -5.467   1.242  16.892  1.00 89.93           C  \\nATOM   3518  CB  ARG A 447      -3.430   2.689  17.374  1.00 89.93           C  \\nATOM   3519  O   ARG A 447      -6.401   1.127  17.682  1.00 89.93           O  \\nATOM   3520  CG  ARG A 447      -4.282   3.713  18.135  1.00 89.93           C  \\nATOM   3521  CD  ARG A 447      -3.481   5.007  18.298  1.00 89.93           C  \\nATOM   3522  NE  ARG A 447      -4.262   6.100  18.911  1.00 89.93           N  \\nATOM   3523  NH1 ARG A 447      -2.985   7.815  18.056  1.00 89.93           N  \\nATOM   3524  NH2 ARG A 447      -4.706   8.300  19.337  1.00 89.93           N  \\nATOM   3525  CZ  ARG A 447      -3.985   7.387  18.769  1.00 89.93           C  \\nATOM   3526  N   GLY A 448      -5.636   1.270  15.574  1.00 91.59           N  \\nATOM   3527  CA  GLY A 448      -6.929   1.206  14.907  1.00 91.59           C  \\nATOM   3528  C   GLY A 448      -7.703  -0.069  15.209  1.00 91.59           C  \\nATOM   3529  O   GLY A 448      -8.854   0.016  15.622  1.00 91.59           O  \\nATOM   3530  N   ALA A 449      -7.074  -1.244  15.090  1.00 92.27           N  \\nATOM   3531  CA  ALA A 449      -7.737  -2.505  15.432  1.00 92.27           C  \\nATOM   3532  C   ALA A 449      -8.197  -2.554  16.892  1.00 92.27           C  \\nATOM   3533  CB  ALA A 449      -6.811  -3.680  15.126  1.00 92.27           C  \\nATOM   3534  O   ALA A 449      -9.303  -3.009  17.163  1.00 92.27           O  \\nATOM   3535  N   ALA A 450      -7.390  -2.049  17.829  1.00 91.57           N  \\nATOM   3536  CA  ALA A 450      -7.799  -1.970  19.228  1.00 91.57           C  \\nATOM   3537  C   ALA A 450      -9.005  -1.038  19.435  1.00 91.57           C  \\nATOM   3538  CB  ALA A 450      -6.604  -1.514  20.058  1.00 91.57           C  \\nATOM   3539  O   ALA A 450      -9.919  -1.381  20.180  1.00 91.57           O  \\nATOM   3540  N   LEU A 451      -9.039   0.112  18.757  1.00 91.10           N  \\nATOM   3541  CA  LEU A 451     -10.175   1.036  18.810  1.00 91.10           C  \\nATOM   3542  C   LEU A 451     -11.443   0.423  18.197  1.00 91.10           C  \\nATOM   3543  CB  LEU A 451      -9.795   2.344  18.098  1.00 91.10           C  \\nATOM   3544  O   LEU A 451     -12.519   0.559  18.774  1.00 91.10           O  \\nATOM   3545  CG  LEU A 451      -8.789   3.226  18.859  1.00 91.10           C  \\nATOM   3546  CD1 LEU A 451      -8.308   4.347  17.937  1.00 91.10           C  \\nATOM   3547  CD2 LEU A 451      -9.402   3.857  20.111  1.00 91.10           C  \\nATOM   3548  N   VAL A 452     -11.328  -0.303  17.080  1.00 91.67           N  \\nATOM   3549  CA  VAL A 452     -12.460  -1.043  16.494  1.00 91.67           C  \\nATOM   3550  C   VAL A 452     -12.971  -2.106  17.465  1.00 91.67           C  \\nATOM   3551  CB  VAL A 452     -12.100  -1.669  15.133  1.00 91.67           C  \\nATOM   3552  O   VAL A 452     -14.178  -2.190  17.687  1.00 91.67           O  \\nATOM   3553  CG1 VAL A 452     -13.252  -2.521  14.583  1.00 91.67           C  \\nATOM   3554  CG2 VAL A 452     -11.826  -0.575  14.095  1.00 91.67           C  \\nATOM   3555  N   SER A 453     -12.075  -2.862  18.105  1.00 91.63           N  \\nATOM   3556  CA  SER A 453     -12.443  -3.814  19.159  1.00 91.63           C  \\nATOM   3557  C   SER A 453     -13.178  -3.136  20.311  1.00 91.63           C  \\nATOM   3558  CB  SER A 453     -11.198  -4.505  19.715  1.00 91.63           C  \\nATOM   3559  O   SER A 453     -14.174  -3.661  20.800  1.00 91.63           O  \\nATOM   3560  OG  SER A 453     -10.627  -5.301  18.704  1.00 91.63           O  \\nATOM   3561  N   ALA A 454     -12.734  -1.949  20.722  1.00 90.17           N  \\nATOM   3562  CA  ALA A 454     -13.364  -1.199  21.798  1.00 90.17           C  \\nATOM   3563  C   ALA A 454     -14.799  -0.767  21.441  1.00 90.17           C  \\nATOM   3564  CB  ALA A 454     -12.437  -0.035  22.159  1.00 90.17           C  \\nATOM   3565  O   ALA A 454     -15.720  -0.944  22.243  1.00 90.17           O  \\nATOM   3566  N   VAL A 455     -15.013  -0.299  20.207  1.00 88.71           N  \\nATOM   3567  CA  VAL A 455     -16.347   0.018  19.668  1.00 88.71           C  \\nATOM   3568  C   VAL A 455     -17.226  -1.237  19.582  1.00 88.71           C  \\nATOM   3569  CB  VAL A 455     -16.220   0.703  18.291  1.00 88.71           C  \\nATOM   3570  O   VAL A 455     -18.390  -1.200  19.989  1.00 88.71           O  \\nATOM   3571  CG1 VAL A 455     -17.576   0.916  17.602  1.00 88.71           C  \\nATOM   3572  CG2 VAL A 455     -15.566   2.084  18.420  1.00 88.71           C  \\nATOM   3573  N   ALA A 456     -16.682  -2.357  19.096  1.00 87.79           N  \\nATOM   3574  CA  ALA A 456     -17.400  -3.628  18.984  1.00 87.79           C  \\nATOM   3575  C   ALA A 456     -17.861  -4.143  20.358  1.00 87.79           C  \\nATOM   3576  CB  ALA A 456     -16.499  -4.640  18.266  1.00 87.79           C  \\nATOM   3577  O   ALA A 456     -19.041  -4.449  20.546  1.00 87.79           O  \\nATOM   3578  N   CYS A 457     -16.964  -4.145  21.350  1.00 87.20           N  \\nATOM   3579  CA  CYS A 457     -17.287  -4.522  22.725  1.00 87.20           C  \\nATOM   3580  C   CYS A 457     -18.365  -3.612  23.330  1.00 87.20           C  \\nATOM   3581  CB  CYS A 457     -16.013  -4.478  23.581  1.00 87.20           C  \\nATOM   3582  O   CYS A 457     -19.307  -4.106  23.949  1.00 87.20           O  \\nATOM   3583  SG  CYS A 457     -14.884  -5.830  23.141  1.00 87.20           S  \\nATOM   3584  N   LYS A 458     -18.271  -2.291  23.127  1.00 84.51           N  \\nATOM   3585  CA  LYS A 458     -19.266  -1.331  23.627  1.00 84.51           C  \\nATOM   3586  C   LYS A 458     -20.657  -1.621  23.053  1.00 84.51           C  \\nATOM   3587  CB  LYS A 458     -18.791   0.094  23.299  1.00 84.51           C  \\nATOM   3588  O   LYS A 458     -21.623  -1.679  23.811  1.00 84.51           O  \\nATOM   3589  CG  LYS A 458     -19.611   1.200  23.985  1.00 84.51           C  \\nATOM   3590  CD  LYS A 458     -19.252   2.560  23.357  1.00 84.51           C  \\nATOM   3591  CE  LYS A 458     -19.936   3.779  23.993  1.00 84.51           C  \\nATOM   3592  NZ  LYS A 458     -19.628   5.015  23.221  1.00 84.51           N  \\nATOM   3593  N   LYS A 459     -20.764  -1.859  21.740  1.00 82.08           N  \\nATOM   3594  CA  LYS A 459     -22.039  -2.206  21.087  1.00 82.08           C  \\nATOM   3595  C   LYS A 459     -22.616  -3.525  21.591  1.00 82.08           C  \\nATOM   3596  CB  LYS A 459     -21.868  -2.276  19.567  1.00 82.08           C  \\nATOM   3597  O   LYS A 459     -23.809  -3.584  21.877  1.00 82.08           O  \\nATOM   3598  CG  LYS A 459     -21.756  -0.883  18.942  1.00 82.08           C  \\nATOM   3599  CD  LYS A 459     -21.750  -1.010  17.418  1.00 82.08           C  \\nATOM   3600  CE  LYS A 459     -21.624   0.379  16.798  1.00 82.08           C  \\nATOM   3601  NZ  LYS A 459     -21.627   0.312  15.320  1.00 82.08           N  \\nATOM   3602  N   ALA A 460     -21.784  -4.555  21.745  1.00 82.22           N  \\nATOM   3603  CA  ALA A 460     -22.218  -5.837  22.295  1.00 82.22           C  \\nATOM   3604  C   ALA A 460     -22.782  -5.684  23.720  1.00 82.22           C  \\nATOM   3605  CB  ALA A 460     -21.036  -6.811  22.245  1.00 82.22           C  \\nATOM   3606  O   ALA A 460     -23.827  -6.250  24.036  1.00 82.22           O  \\nATOM   3607  N   CYS A 461     -22.149  -4.851  24.555  1.00 79.15           N  \\nATOM   3608  CA  CYS A 461     -22.652  -4.526  25.891  1.00 79.15           C  \\nATOM   3609  C   CYS A 461     -23.994  -3.777  25.867  1.00 79.15           C  \\nATOM   3610  CB  CYS A 461     -21.598  -3.700  26.640  1.00 79.15           C  \\nATOM   3611  O   CYS A 461     -24.814  -4.020  26.745  1.00 79.15           O  \\nATOM   3612  SG  CYS A 461     -20.197  -4.751  27.118  1.00 79.15           S  \\nATOM   3613  N   MET A 462     -24.232  -2.889  24.893  1.00 75.71           N  \\nATOM   3614  CA  MET A 462     -25.513  -2.175  24.769  1.00 75.71           C  \\nATOM   3615  C   MET A 462     -26.651  -3.072  24.271  1.00 75.71           C  \\nATOM   3616  CB  MET A 462     -25.396  -0.979  23.817  1.00 75.71           C  \\nATOM   3617  O   MET A 462     -27.776  -2.903  24.712  1.00 75.71           O  \\nATOM   3618  CG  MET A 462     -24.501   0.146  24.332  1.00 75.71           C  \\nATOM   3619  SD  MET A 462     -24.649   1.631  23.303  1.00 75.71           S  \\nATOM   3620  CE  MET A 462     -23.136   2.505  23.741  1.00 75.71           C  \\nATOM   3621  N   LEU A 463     -26.373  -4.009  23.358  1.00 73.26           N  \\nATOM   3622  CA  LEU A 463     -27.381  -4.937  22.823  1.00 73.26           C  \\nATOM   3623  C   LEU A 463     -27.736  -6.072  23.796  1.00 73.26           C  \\nATOM   3624  CB  LEU A 463     -26.863  -5.528  21.499  1.00 73.26           C  \\nATOM   3625  O   LEU A 463     -28.789  -6.689  23.659  1.00 73.26           O  \\nATOM   3626  CG  LEU A 463     -26.836  -4.539  20.322  1.00 73.26           C  \\nATOM   3627  CD1 LEU A 463     -26.060  -5.161  19.159  1.00 73.26           C  \\nATOM   3628  CD2 LEU A 463     -28.243  -4.196  19.826  1.00 73.26           C  \\nATOM   3629  N   GLY A 464     -26.842  -6.382  24.738  1.00 62.21           N  \\nATOM   3630  CA  GLY A 464     -27.078  -7.371  25.791  1.00 62.21           C  \\nATOM   3631  C   GLY A 464     -27.823  -6.834  27.021  1.00 62.21           C  \\nATOM   3632  O   GLY A 464     -28.141  -7.631  27.906  1.00 62.21           O  \\nATOM   3633  N   GLN A 465     -28.059  -5.519  27.098  1.00 42.57           N  \\nATOM   3634  CA  GLN A 465     -28.887  -4.853  28.115  1.00 42.57           C  \\nATOM   3635  C   GLN A 465     -30.327  -4.736  27.624  1.00 42.57           C  \\nATOM   3636  CB  GLN A 465     -28.321  -3.456  28.420  1.00 42.57           C  \\nATOM   3637  O   GLN A 465     -31.233  -4.931  28.469  1.00 42.57           O  \\nATOM   3638  CG  GLN A 465     -27.037  -3.520  29.252  1.00 42.57           C  \\nATOM   3639  CD  GLN A 465     -26.400  -2.153  29.511  1.00 42.57           C  \\nATOM   3640  NE2 GLN A 465     -25.247  -2.123  30.145  1.00 42.57           N  \\nATOM   3641  OE1 GLN A 465     -26.898  -1.082  29.204  1.00 42.57           O  \\nATOM   3642  OXT GLN A 465     -30.476  -4.421  26.425  1.00 42.57           O  \\nEND   \"],\"format\":\"pdb\",\"keepH\":false,\"options\":{\"keepH\":false}},{\"method\":\"setStyle\",\"style\":{\"cartoon\":{\"style\":\"rectangle\",\"ribbon\":false,\"arrows\":true,\"tubes\":false,\"thickness\":0.4,\"opacity\":1,\"colorfunc\":\"function(atom) {\\n    const residue_colors = [ 'gray', '#023FA5', '#5D6CAE', '#5D6CAE', '#8C94BF', '#5D6CAE', '#B3B7CF', '#5D6CAE', '#5D6CAE', '#5D6CAE', '#5D6CAE', '#8C94BF', '#5D6CAE', '#5D6CAE', '#8C94BF', '#E2E2E2', '#5D6CAE', '#5D6CAE', '#8C94BF', '#AB5468', '#5D6CAE', '#5D6CAE', '#8E063B', '#5D6CAE', '#DDD0D2', '#023FA5', '#5D6CAE', '#023FA5', '#8C94BF', '#E2E2E2', '#5D6CAE', '#5D6CAE', '#DDD0D2', '#DDD0D2', '#5D6CAE', '#D2D3DC', '#D2B0B6', '#B3B7CF', '#5D6CAE', '#D2B0B6', '#AB5468', '#5D6CAE', '#B3B7CF', '#8E063B', '#8E063B', '#8C94BF', '#023FA5', '#5D6CAE', '#8C94BF', '#E2E2E2', '#5D6CAE', '#5D6CAE', '#D2B0B6', '#E2E2E2', '#C18692', '#AB5468', '#8E063B', '#8E063B', '#8E063B', '#C18692', '#C18692', '#8E063B', '#B3B7CF', '#B3B7CF', '#D2D3DC', '#8E063B', '#5D6CAE', '#AB5468', '#5D6CAE', '#8E063B', '#8C94BF', '#8E063B', '#DDD0D2', '#8E063B', '#8E063B', '#D2B0B6', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#D2B0B6', '#8E063B', '#8E063B', '#AB5468', '#AB5468', '#D2D3DC', '#C18692', '#8C94BF', '#DDD0D2', '#B3B7CF', '#5D6CAE', '#5D6CAE', '#023FA5', '#023FA5', '#5D6CAE', '#5D6CAE', '#DDD0D2', '#5D6CAE', '#D2D3DC', '#023FA5', '#B3B7CF', '#5D6CAE', '#8C94BF', '#8C94BF', '#D2D3DC', '#AB5468', '#5D6CAE', '#AB5468', '#D2B0B6', '#5D6CAE', '#8C94BF', '#D2D3DC', '#D2B0B6', '#5D6CAE', '#8E063B', '#8C94BF', '#DDD0D2', '#B3B7CF', '#D2D3DC', '#8E063B', '#8E063B', '#8E063B', '#E2E2E2', '#C18692', '#DDD0D2', '#5D6CAE', '#8E063B', '#D2B0B6', '#E2E2E2', '#B3B7CF', '#8E063B', '#AB5468', '#5D6CAE', '#5D6CAE', '#8C94BF', '#5D6CAE', '#8C94BF', '#D2B0B6', '#5D6CAE', '#B3B7CF', '#B3B7CF', '#AB5468', '#D2B0B6', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#C18692', '#B3B7CF', '#C18692', '#8C94BF', '#B3B7CF', '#DDD0D2', '#AB5468', '#D2D3DC', '#8E063B', '#B3B7CF', '#8E063B', '#D2B0B6', '#8C94BF', '#8E063B', '#AB5468', '#8E063B', '#8E063B', '#8E063B', '#D2D3DC', '#DDD0D2', '#5D6CAE', '#AB5468', '#D2D3DC', '#D2D3DC', '#AB5468', '#8C94BF', '#C18692', '#C18692', '#AB5468', '#D2D3DC', '#C18692', '#8E063B', '#D2B0B6', '#D2D3DC', '#AB5468', '#C18692', '#8C94BF', '#AB5468', '#8E063B', '#D2D3DC', '#E2E2E2', '#AB5468', '#8C94BF', '#DDD0D2', '#DDD0D2', '#AB5468', '#D2B0B6', '#C18692', '#D2B0B6', '#C18692', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#8E063B', '#D2B0B6', '#C18692', '#8E063B', '#B3B7CF', '#E2E2E2', '#8C94BF', '#C18692', '#5D6CAE', '#5D6CAE', '#8E063B', '#C18692', '#C18692', '#8E063B', '#D2B0B6', '#8E063B', '#C18692', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#8E063B', '#D2D3DC', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#B3B7CF', '#C18692', '#5D6CAE', '#B3B7CF', '#D2B0B6', '#8C94BF', '#D2D3DC', '#D2D3DC', '#5D6CAE', '#D2B0B6', '#5D6CAE', '#5D6CAE', '#AB5468', '#DDD0D2', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#D2B0B6', '#8E063B', '#8E063B', '#8E063B', '#C18692', '#8E063B', '#8E063B', '#D2D3DC', '#5D6CAE', '#D2D3DC', '#E2E2E2', '#8E063B', '#5D6CAE', '#5D6CAE', '#AB5468', '#8C94BF', '#D2D3DC', '#5D6CAE', '#C18692', '#8E063B', '#B3B7CF', '#023FA5', '#D2B0B6', '#8E063B', '#5D6CAE', '#5D6CAE', '#C18692', '#5D6CAE', '#B3B7CF', '#8C94BF', '#DDD0D2', '#5D6CAE', '#AB5468', '#8C94BF', '#AB5468', '#8E063B', '#8E063B', '#D2B0B6', '#D2D3DC', '#AB5468', '#8E063B', '#AB5468', '#8E063B', '#C18692', '#8E063B', '#8E063B', '#AB5468', '#AB5468', '#8E063B', '#B3B7CF', '#E2E2E2', '#8E063B', '#E2E2E2', '#B3B7CF', '#C18692', '#E2E2E2', '#5D6CAE', '#8C94BF', '#8C94BF', '#E2E2E2', '#8E063B', '#8E063B', '#5D6CAE', '#C18692', '#5D6CAE', '#5D6CAE', '#B3B7CF', '#5D6CAE', '#5D6CAE', '#8E063B', '#8C94BF', '#5D6CAE', '#B3B7CF', '#C18692', '#5D6CAE', '#8E063B', '#B3B7CF', '#AB5468', '#DDD0D2', '#C18692', '#C18692', '#AB5468', '#8C94BF', '#DDD0D2', '#8E063B', '#B3B7CF', '#D2B0B6', '#5D6CAE', '#8C94BF', '#B3B7CF', '#D2D3DC', '#B3B7CF', '#8C94BF', '#B3B7CF', '#8C94BF', '#8C94BF', '#D2B0B6', '#8E063B', '#B3B7CF', '#5D6CAE', '#DDD0D2', '#DDD0D2', '#C18692', '#5D6CAE', '#D2B0B6', '#8C94BF', '#023FA5', '#5D6CAE', '#8E063B', '#C18692', '#B3B7CF', '#8C94BF', '#D2B0B6', '#D2D3DC', '#8C94BF', '#B3B7CF', '#8E063B', '#B3B7CF', '#8C94BF', '#AB5468', '#AB5468', '#5D6CAE', '#8E063B', '#AB5468', '#AB5468', '#5D6CAE', '#DDD0D2', '#AB5468', '#AB5468', '#DDD0D2', '#8E063B', '#8E063B', '#D2B0B6', '#D2B0B6', '#C18692', '#D2B0B6', '#8C94BF', '#DDD0D2', '#DDD0D2', '#E2E2E2', '#5D6CAE', '#8C94BF', '#E2E2E2', '#5D6CAE', '#5D6CAE', '#5D6CAE', '#5D6CAE', '#D2D3DC', '#8C94BF', '#E2E2E2', '#DDD0D2', '#AB5468', '#8E063B', '#C18692', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#8E063B', '#8E063B', '#8C94BF', '#8E063B', '#AB5468', '#5D6CAE', '#8E063B', '#E2E2E2', '#5D6CAE', '#D2D3DC', '#C18692', '#B3B7CF', '#5D6CAE', '#8C94BF', '#E2E2E2', '#5D6CAE', '#5D6CAE', '#AB5468', '#D2D3DC', '#8C94BF', '#5D6CAE', '#D2B0B6', '#5D6CAE', '#E2E2E2', '#5D6CAE', '#8E063B', '#8C94BF', '#8C94BF', '#AB5468', '#8C94BF', '#D2D3DC', '#8E063B', '#8E063B', '#AB5468', '#D2B0B6', '#8E063B', '#C18692', '#8E063B', '#8E063B', '#AB5468', '#C18692', '#AB5468', '#DDD0D2', '#D2D3DC', '#8C94BF', '#E2E2E2', '#8C94BF', '#5D6CAE', '#5D6CAE', '#5D6CAE', '#023FA5', '#5D6CAE', '#5D6CAE' ];\\n    return residue_colors[atom.resi];\\n}\"}},\"sel\":{}},{\"method\":\"zoomTo\"}]},\"evals\":[],\"jsHooks\":[]} ## no AlphaFold prediction for this protein P35555 <-     am_data(\"aa_substitutions\") |>     dplyr::filter(uniprot_id == \"P35555\") tryCatch({     af_prediction_view(P35555) }, error = identity) #> <simpleError in af_prediction_view(P35555): 'af_prediction_view()' could not find UniProt accession 'P35555'>   ## af_colorfunc_by_position()  df <- tibble(     pos = 1 + 1:10, # no color information for position 1     value = 10:1 / 10 ) colorfunc <- af_colorfunc_by_position(     df,     \"pos\", \"value\",     pos_max = 12    # no color information for position 12 ) cat(colorfunc) #> function(atom) { #>     const residue_colors = [ 'gray', '#8E063B', '#AB5468', '#C18692', '#D2B0B6', '#DDD0D2', '#D2D3DC', '#B3B7CF', '#8C94BF', '#5D6CAE', '#023FA5', 'gray' ]; #>     return residue_colors[atom.resi]; #> }  ## template used for Javascript function cat(     AlphaMissenseR:::js_template(\"colorfunc\", colors = \"...\"),     \"\\n\" ) #> function(atom) { #>     const residue_colors = [ ... ]; #>     return residue_colors[atom.resi]; #> }"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":null,"dir":"Reference","previous_headings":"","what":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"ALPHAMISSENSE_RECORD constant identifier corresponding default version AlphaMissense resource use. am_browse() opens web browser Zenodo record AlphaMissense data. am_available() reports available datasets record. am_data() retrieves single key AlpahMissense Zenodo site parses file DuckDB database.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"","code":"ALPHAMISSENSE_RECORD  am_browse(record = ALPHAMISSENSE_RECORD)  am_available(record = ALPHAMISSENSE_RECORD, bfc = BiocFileCache())  am_data(     key,     record = ALPHAMISSENSE_RECORD,     bfc = BiocFileCache(),     as = c(\"tbl\", \"tsv\") )"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"object class character length 1.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"record character(1) Zenodo record AlphaMissense data resources. bfc object returned BiocFileCache() representing location downloaded files parsed database stored. default 'global' BiocFileCache. key character(1) 'key' result am_available(), single row tibble returned am_available(). chracter(1) type return value. \"tbl\": dbplyr tbl representation database resource. \"tsv\": path tsv.gz file representing resource downloaded Zenodo","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"am_available() returns tibble columns key, size, link. meaning key must determined reference information am_browse(). am_data() returns dbplyr (database) tibble represented downloaded parsed file. Fields database described Zenodo resource page.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"ALPHAMISSENSE_RECORD can set package loaded environment variable name, e.g., Sys.setenv(ALPHAMISSENSE_RECORD = \"10813168\"). default recent version (version 3) checked 11 April, 2024. am_data() uses BiocFileCache download store file corresponding DuckDB database.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"","code":"ALPHAMISSENSE_RECORD #> [1] \"10813168\"  if (interactive())     am_browse()  am_available() #> # A tibble: 7 × 6 #>   record   key                             size cached filename            link  #>   <chr>    <chr>                          <dbl> <lgl>  <chr>               <chr> #> 1 10813168 gene_hg38                     253636 TRUE   AlphaMissense_gene… http… #> 2 10813168 isoforms_hg38             1177361934 FALSE  AlphaMissense_isof… http… #> 3 10813168 isoforms_aa_substitutions 2461351945 FALSE  AlphaMissense_isof… http… #> 4 10813168 hg38                       642961469 TRUE   AlphaMissense_hg38… http… #> 5 10813168 hg19                       622293310 FALSE  AlphaMissense_hg19… http… #> 6 10813168 gene_hg19                     243943 FALSE  AlphaMissense_gene… http… #> 7 10813168 aa_substitutions          1207278510 TRUE   AlphaMissense_aa_s… http…  am_data(\"hg38\") #> # Source:   table<hg38> [?? x 10] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr> <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr1  69094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L             #>  2 chr1  69094 G     C     hg38   Q8NH21     ENST00000335137.4 V2L             #>  3 chr1  69094 G     A     hg38   Q8NH21     ENST00000335137.4 V2M             #>  4 chr1  69095 T     C     hg38   Q8NH21     ENST00000335137.4 V2A             #>  5 chr1  69095 T     A     hg38   Q8NH21     ENST00000335137.4 V2E             #>  6 chr1  69095 T     G     hg38   Q8NH21     ENST00000335137.4 V2G             #>  7 chr1  69097 A     G     hg38   Q8NH21     ENST00000335137.4 T3A             #>  8 chr1  69097 A     C     hg38   Q8NH21     ENST00000335137.4 T3P             #>  9 chr1  69097 A     T     hg38   Q8NH21     ENST00000335137.4 T3S             #> 10 chr1  69098 C     A     hg38   Q8NH21     ENST00000335137.4 T3N             #> # ℹ more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr>  ## close the connection opened when adding the data db_disconnect()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":null,"dir":"Reference","previous_headings":"","what":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"clinvar_data() loads ClinVar information supplemental table AlphaMissense [2023] paper. clinvar_plot() integrates ClinVar classifications AlphaMissense predicted scores derived am_data(\"aa_substitutions\") returns ggplot object visualization.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"","code":"clinvar_data(record = ALPHAMISSENSE_RECORD, bfc = BiocFileCache())  clinvar_plot(uniprotId, alphamissense_table, clinvar_table)"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"record character(1) Zenodo record AlphaMissense data resources. bfc object returned BiocFileCache() representing location AlphaMissenseR database. default 'global' BiocFileCache. uniprotId character() valid UniProt accession identifier. alphamissense_table table containing AlphaMissense predictions protein variants. default, table derived am_data(\"aa_substitution\"). Alternatively, user-defined tibble::tbl_df data.frame can supplied. clinvar_table table containing ClinVar information. default, table derived supplemental data AlphaMissense paper. Alternatively, user-defined tibble::tbl_df data.frame can supplied.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"clinvar_data() returns tbl 82872 rows 5 variables: variant_id: ClinVar variant identifier. transcript_id: Ensembl transcript identifier. protein_variant: UniProt accession:protein variant identifier. AlphaMissense: AlphaMissense pathogenicity score. label: Binary ClinVar class, either \"benign\" \"pathogenic\". clinvar_plot() returns ggplot object overlays ClinVar classifications onto AlphaMissense predicted scores. Blue, gray, red colors represent pathogenicity classifications \"likely benign\", \"ambiguous\", \"likely pathogenic\", respectively. Large, bolded points ClinVar variants colored according clinical classification, smaller points background AlphaMissense predictions.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"clinvar_plot(),  alphamissense_table columns must include: uniprot_id: UniProt accession identifier. protein_variant: variant identifier string, protein position middle, reference mutant amino acid residues left right position, respectively. am_class: AlphaMissense classification either \"benign\", \"ambiguous\", \"pathogenic\". am_pathogenicity: AlphaMissense predicted score. clinvar_table columns must include: uniprot_id: UniProt accession identifier, matching alphamissense_table. protein_variant: variant identifier string, matching alphamissense_table format. cv_class: binary ClinVar classification \"benign\" \"pathogenic\".","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":"references","dir":"Reference","previous_headings":"","what":"References","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"Cheng et al., Accurate proteome-wide missense variant effect prediction AlphaMissense. Science 381, eadg7492. DOI:10.1126/science.adg7492.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"","code":"clinvar_data() #> # Source:   table<clinvar> [?? x 5] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>    variant_id           transcript_id     protein_variant AlphaMissense label  #>    <chr>                <chr>             <chr>                   <dbl> <fct>  #>  1 chr1_925969_C_T_hg38 ENST00000342066.8 Q96NU1:P10S            0.967  benign #>  2 chr1_930165_G_A_hg38 ENST00000342066.8 Q96NU1:R28Q            0.663  benign #>  3 chr1_930204_G_A_hg38 ENST00000342066.8 Q96NU1:R41Q            0.0866 benign #>  4 chr1_930245_G_A_hg38 ENST00000342066.8 Q96NU1:D55N            0.134  benign #>  5 chr1_930248_G_A_hg38 ENST00000342066.8 Q96NU1:G56S            0.100  benign #>  6 chr1_930282_G_A_hg38 ENST00000342066.8 Q96NU1:R67Q            0.0635 benign #>  7 chr1_930285_G_A_hg38 ENST00000342066.8 Q96NU1:R68Q            0.0629 benign #>  8 chr1_930314_C_T_hg38 ENST00000342066.8 Q96NU1:H78Y            0.110  benign #>  9 chr1_930320_C_T_hg38 ENST00000342066.8 Q96NU1:R80C            0.0918 benign #> 10 chr1_931058_G_A_hg38 ENST00000342066.8 Q96NU1:V92M            0.196  benign #> # ℹ more rows  alphamissense_table <- am_data(\"aa_substitutions\")  clinvar_plot(     uniprotId = \"P37023\",     alphamissense_table = alphamissense_table ) #> * [14:04:41][info] 'clinvar_table' not provided, using default ClinVar dataset in AlphaMissenseR package"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/GenomicRanges.html","id":null,"dir":"Reference","previous_headings":"","what":"Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos","title":"Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos","text":"to_GPos() coerces tibble derived am_data(\"hg19\") am_data(\"hg38\") resources GenomicRanges GPos objects.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/GenomicRanges.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos","text":"","code":"to_GPos(tbl)"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/GenomicRanges.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos","text":"tbl tibble derived am_data(\"hg19\") am_data(\"hg38\"). tibble must columns CHROM, POS, genome.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/GenomicRanges.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos","text":"to_GPos() returns GPos object, can used GRanges object range-based filtering annotation","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/GenomicRanges.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos","text":"","code":"am_data(\"hg38\") |>     filter(CHROM == \"chr2\", POS < 10000000, REF == \"G\") |>     select(-REF) |>     to_GPos() #> UnstitchedGPos object with 26751 positions and 6 metadata columns: #>           seqnames       pos strand |         ALT  uniprot_id #>              <Rle> <integer>  <Rle> | <character> <character> #>       [1]     chr2     41613      * |           C      Q1W6H9 #>       [2]     chr2     41615      * |           C      Q1W6H9 #>       [3]     chr2     41615      * |           A      Q1W6H9 #>       [4]     chr2     41615      * |           T      Q1W6H9 #>       [5]     chr2     41618      * |           C      Q1W6H9 #>       ...      ...       ...    ... .         ...         ... #>   [26747]     chr2   9999028      * |           A      Q9NZI5 #>   [26748]     chr2   9999028      * |           T      Q9NZI5 #>   [26749]     chr2   9999029      * |           C      Q9NZI5 #>   [26750]     chr2   9999029      * |           A      Q9NZI5 #>   [26751]     chr2   9999029      * |           T      Q9NZI5 #>                transcript_id protein_variant am_pathogenicity          am_class #>                  <character>     <character>        <numeric>       <character> #>       [1]  ENST00000327669.5           R321G           0.0848     likely_benign #>       [2]  ENST00000327669.5           S320C           0.0946     likely_benign #>       [3]  ENST00000327669.5           S320F           0.1593     likely_benign #>       [4]  ENST00000327669.5           S320Y           0.1429     likely_benign #>       [5]  ENST00000327669.5           P319R           0.0765     likely_benign #>       ...                ...             ...              ...               ... #>   [26747] ENST00000324907.14           G581R           0.9997 likely_pathogenic #>   [26748] ENST00000324907.14           G581W           0.9996 likely_pathogenic #>   [26749] ENST00000324907.14           G581A           0.9970 likely_pathogenic #>   [26750] ENST00000324907.14           G581E           0.9995 likely_pathogenic #>   [26751] ENST00000324907.14           G581V           0.9994 likely_pathogenic #>   ------- #>   seqinfo: 25 sequences (1 circular) from hg38 genome"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html","id":null,"dir":"Reference","previous_headings":"","what":"Common Amino Acid-level Transformations — am_aa_pos","title":"Common Amino Acid-level Transformations — am_aa_pos","text":"am_aa_pos() separates protein_variant columns amino acide 'pos', 'ref', 'alt' columns. am_aa_pathogenicity() summarizes pathogenicity scores protein amino acid position.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Common Amino Acid-level Transformations — am_aa_pos","text":"","code":"am_aa_pos(tbl)  am_aa_pathogenicity(tbl)"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Common Amino Acid-level Transformations — am_aa_pos","text":"tbl tibble, usually derived am_data(\"aa_substitutions\"), `am_data(\"hg38\"), etc. See details.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Common Amino Acid-level Transformations — am_aa_pos","text":"am_aa_pos() returns original table additional columns aa_pos: position protein variant, integer(). aa_ref: single-character reference amino acid protein variant. aa_alt: single-character alternate amino acid protein variant. am_aa_pathogenicity() returns tibble columns uniprot_id, aa_pos, aa_ref: UniProt id, position reference amino acid summarized aa_pathogenicity_n, aa_pathogenicity_mean, aa_pathogenicity_median, aa_pathogenicity_min, aa_pathogenicity_max: number, average, median, minimum, maximum pathogenicity scores amino acid position. aa_pathogenicity_mode: modal am_class amino acid position, factor. Tied mode assigned lower pathogenicity.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Common Amino Acid-level Transformations — am_aa_pos","text":"tbl collect()ed computation, rows must fit memory. am_aa_pos(), tbl must contain column protein_variant entries form \"Q465H\", AlphaMissense data. am_aa_pathogenicity(), tbl must contain columns uniprot_id, protein_variant, am_pathogenicity am_class. am_pos friends already calculated, am_aa_pos() called.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Common Amino Acid-level Transformations — am_aa_pos","text":"","code":"P35557 <-     am_data(\"hg38\") |>     filter(uniprot_id %in% \"P35557\")  am_aa_pos(P35557) #> # A tibble: 3,085 × 13 #>    CHROM      POS REF   ALT   genome uniprot_id transcript_id    protein_variant #>    <chr>    <dbl> <chr> <chr> <chr>  <chr>      <chr>            <chr>           #>  1 chr7  44145139 C     A     hg38   P35557     ENST00000403799… Q465H           #>  2 chr7  44145139 C     G     hg38   P35557     ENST00000403799… Q465H           #>  3 chr7  44145140 T     C     hg38   P35557     ENST00000403799… Q465R           #>  4 chr7  44145140 T     A     hg38   P35557     ENST00000403799… Q465L           #>  5 chr7  44145140 T     G     hg38   P35557     ENST00000403799… Q465P           #>  6 chr7  44145141 G     C     hg38   P35557     ENST00000403799… Q465E           #>  7 chr7  44145141 G     T     hg38   P35557     ENST00000403799… Q465K           #>  8 chr7  44145143 C     G     hg38   P35557     ENST00000403799… G464A           #>  9 chr7  44145143 C     T     hg38   P35557     ENST00000403799… G464D           #> 10 chr7  44145143 C     A     hg38   P35557     ENST00000403799… G464V           #> # ℹ 3,075 more rows #> # ℹ 5 more variables: am_pathogenicity <dbl>, am_class <chr>, aa_pos <int>, #> #   aa_ref <chr>, aa_alt <chr>  am_aa_pos(P35557) |>     select(         uniprot_id, POS, REF, ALT, protein_variant,         starts_with(\"aa_\"), am_pathogenicity, am_class     ) |>     arrange(aa_pos) #> # A tibble: 3,085 × 10 #>    uniprot_id      POS REF   ALT   protein_variant aa_pos aa_ref aa_alt #>    <chr>         <dbl> <chr> <chr> <chr>            <int> <chr>  <chr>  #>  1 P35557     44188949 A     C     L2R                  2 L      R      #>  2 P35557     44188949 A     T     L2Q                  2 L      Q      #>  3 P35557     44188949 A     G     L2P                  2 L      P      #>  4 P35557     44188950 G     T     L2M                  2 L      M      #>  5 P35557     44188950 G     C     L2V                  2 L      V      #>  6 P35557     44188945 G     C     D3E                  3 D      E      #>  7 P35557     44188945 G     T     D3E                  3 D      E      #>  8 P35557     44188946 T     G     D3A                  3 D      A      #>  9 P35557     44188946 T     C     D3G                  3 D      G      #> 10 P35557     44188946 T     A     D3V                  3 D      V      #> # ℹ 3,075 more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr>   am_aa_pathogenicity(P35557) #> # A tibble: 464 × 9 #>    uniprot_id aa_pos aa_ref aa_pathogenicity_n aa_pathogenicity_mean #>    <chr>       <int> <chr>               <int>                 <dbl> #>  1 P35557          2 L                       5                0.0818 #>  2 P35557          3 D                       8                0.184  #>  3 P35557          4 D                       8                0.147  #>  4 P35557          5 R                       6                0.250  #>  5 P35557          6 A                       6                0.138  #>  6 P35557          7 R                       7                0.257  #>  7 P35557          8 M                       9                0.142  #>  8 P35557          9 E                       7                0.212  #>  9 P35557         10 A                       6                0.142  #> 10 P35557         11 A                       6                0.142  #> # ℹ 454 more rows #> # ℹ 4 more variables: aa_pathogenicity_median <dbl>, #> #   aa_pathogenicity_min <dbl>, aa_pathogenicity_max <dbl>, #> #   aa_pathogenicity_mode <fct>"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/db.html","id":null,"dir":"Reference","previous_headings":"","what":"Manipulate the Database of Missense Mutations — db_connect","title":"Manipulate the Database of Missense Mutations — db_connect","text":"db_connect() manages connections AlphaMissense record-specific databases. default, connections created reused. db_tables() queries names temporary regular tables defined database. db_temporary_table() creates temporary (duration duckdb connection) table tibble. db_range_join() performs range join, finding positions key within ranges defined join. result stored table . db_disconnect() disconnects duckdb database shuts DuckDB server associated connection. Temporary tables lost. db_disconnect_all() disconnects managed duckdb database connection.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/db.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Manipulate the Database of Missense Mutations — db_connect","text":"","code":"db_connect(     record = ALPHAMISSENSE_RECORD,     bfc = BiocFileCache(),     read_only = TRUE,     managed = read_only )  db_tables(db = db_connect())  db_temporary_table(db, value, to)  db_range_join(db, key, join, to)  db_disconnect(db = db_connect())  db_disconnect_all()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/db.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Manipulate the Database of Missense Mutations — db_connect","text":"record character(1) Zenodo record AlphaMissense data resources. bfc object returned BiocFileCache() representing location downloaded files parsed database stored. default 'global' BiocFileCache. read_only logical(1) open connection 'read '. TRUE protects overwriting existing data default. managed logical(1) TRUE, re-use existing managed connection database. db duckdb_connection object, returned db_connect(). value data.frame / tibble containing data placed temporary table, e.g., GenomicRanges object used range join. character(1) name table created key character(1) table name db containing missense mutation coordinates. join character(1) table name db containing ranges used joining (filtering) key.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/db.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Manipulate the Database of Missense Mutations — db_connect","text":"db_connect() returns open duckdb_connection AlphaMissense record-specific database. db_tables() returns character vector database table names. db_temporary_table() returns temporary table dbplyr tibble. db_range_join() returns (temporary table created join) dbplyr tibble. db_disconnect() returns FALSE connection already closed valid (via dbIsValid()) TRUE disconnection successful. Values returned invisibly. db_disconnect_all() returns db_disconnect() value connection, invisibly.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/db.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Manipulate the Database of Missense Mutations — db_connect","text":"db_connect(), set managed = FALSE , instance, accessing database separate process. Remember capture database connection db_unmanaged <- db_connect(managed = FALSE) disconnect done `db_disconnect(db_unmanaged). Connections managed default. db_temporary_table() overwrites existing table name . db_range_join() overwrites existing table . table key usually \"hg19\" \"hg38\" must CHROM POS columns. table join must columns CHROM, start end. Following Bioconductor convention reported am_browse(), coordinates 1-based ranges defined start end closed. columns key join included, column names (CHROM) duplicated. db_disconnect() called unmanaged connection, (free default managed connection) end session.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/db.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Manipulate the Database of Missense Mutations — db_connect","text":"","code":"db_connect()          # default 'read-only' connection #> alphamissense_connection (read_only: TRUE; managed: TRUE) #> record: '10813168' #> connected: TRUE #> tables: aa_substitutions, clinvar, gene_hg38, hg38  db_rw <- db_connect(read_only = FALSE)  am_data(\"hg38\")       # uses the default, 'read-only' connection #> # Source:   table<hg38> [?? x 10] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr> <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr1  69094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L             #>  2 chr1  69094 G     C     hg38   Q8NH21     ENST00000335137.4 V2L             #>  3 chr1  69094 G     A     hg38   Q8NH21     ENST00000335137.4 V2M             #>  4 chr1  69095 T     C     hg38   Q8NH21     ENST00000335137.4 V2A             #>  5 chr1  69095 T     A     hg38   Q8NH21     ENST00000335137.4 V2E             #>  6 chr1  69095 T     G     hg38   Q8NH21     ENST00000335137.4 V2G             #>  7 chr1  69097 A     G     hg38   Q8NH21     ENST00000335137.4 T3A             #>  8 chr1  69097 A     C     hg38   Q8NH21     ENST00000335137.4 T3P             #>  9 chr1  69097 A     T     hg38   Q8NH21     ENST00000335137.4 T3S             #> 10 chr1  69098 C     A     hg38   Q8NH21     ENST00000335137.4 T3N             #> # ℹ more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr> db_tables()           # connections initially share the same tables #> [1] \"aa_substitutions\" \"clinvar\"          \"gene_hg38\"        \"hg38\"             db_tables(db_rw) #> [1] \"aa_substitutions\" \"clinvar\"          \"gene_hg38\"        \"hg38\"              ## ranges of interest -- the first 200000 bases on chromsomes 1-4. ranges <- tibble(     CHROM = paste0(\"chr\", 1:4),     start = rep(1, 4),     end = rep(200000, 4) ) db_temporary_table(db_rw, ranges, \"ranges\") #> # Source:   table<ranges> [4 x 3] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>   CHROM start    end #>   <chr> <dbl>  <dbl> #> 1 chr1      1 200000 #> 2 chr2      1 200000 #> 3 chr3      1 200000 #> 4 chr4      1 200000  db_tables(db_rw)      # temporary table available to the db_rw connection... #> [1] \"aa_substitutions\" \"clinvar\"          \"gene_hg38\"        \"hg38\"             #> [5] \"ranges\"           db_tables()           # ...but not to the read-only connection #> [1] \"aa_substitutions\" \"clinvar\"          \"gene_hg38\"        \"hg38\"              rng <- db_range_join(db_rw, \"hg38\", \"ranges\", \"ranges_overlaps\") rng #> # Source:   table<ranges_overlaps> [?? x 12] #> # Database: DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr> <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr2  41612 C     T     hg38   Q1W6H9     ENST00000327669.5 R321Q           #>  2 chr2  41612 C     A     hg38   Q1W6H9     ENST00000327669.5 R321L           #>  3 chr2  41612 C     G     hg38   Q1W6H9     ENST00000327669.5 R321P           #>  4 chr2  41613 G     C     hg38   Q1W6H9     ENST00000327669.5 R321G           #>  5 chr2  41615 G     C     hg38   Q1W6H9     ENST00000327669.5 S320C           #>  6 chr2  41615 G     A     hg38   Q1W6H9     ENST00000327669.5 S320F           #>  7 chr2  41615 G     T     hg38   Q1W6H9     ENST00000327669.5 S320Y           #>  8 chr2  41616 A     C     hg38   Q1W6H9     ENST00000327669.5 S320A           #>  9 chr2  41616 A     G     hg38   Q1W6H9     ENST00000327669.5 S320P           #> 10 chr2  41616 A     T     hg38   Q1W6H9     ENST00000327669.5 S320T           #> # ℹ more rows #> # ℹ 4 more variables: am_pathogenicity <dbl>, am_class <chr>, start <dbl>, #> #   end <dbl> rng |>     count(CHROM) |>     arrange(CHROM) #> # Source:     SQL [3 x 2] #> # Database:   DuckDB v1.0.0 [ma38727@Darwin 23.5.0:R 4.4.1//Users/ma38727/Library/Caches/org.R-project.R/R/BiocFileCache/a3a01776fe5e_a3a01776fe5e] #> # Ordered by: CHROM #>   CHROM     n #>   <chr> <dbl> #> 1 chr1   2018 #> 2 chr2   2028 #> 3 chr4   7488  db_disconnect(db_rw)  # explicit read-write connection db_disconnect()       # implicit read-only connection  db_disconnect_all()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/news/index.html","id":"alphamissenser-120","dir":"Changelog","previous_headings":"","what":"AlphaMissenseR 1.2.0","title":"AlphaMissenseR 1.2.0","text":"(v. 1.1.4) Add clinvar_data() clinvar_plot() visualizing ClinVar data. Merges https://github.com/mtmorgan/AlphaMissenseR/pull/4 Thanks @tram-nguyen-n (v. 1.1.2) af_predictions() returns tibble 21 columns, instead 20. Merges https://github.com/mtmorgan/AlphaMissenseR/pull/3.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/news/index.html","id":"alphamissenser-100","dir":"Changelog","previous_headings":"","what":"AlphaMissenseR 1.0.0","title":"AlphaMissenseR 1.0.0","text":"(v. 0.99.21) Update Zenodo data source record 10813168, accessible ‘CC--4.0’ license. Order vignettes introduction, visualization, issues. Use rjsoncons (>= 1.0.1), jsonlite hard dependency. Acknowledge additional funding sources; add ImmunoOncology biocViews term. Use BiocBaseUtils input assertions. Include range join SQL directly rather via non-exported function. Report file size downloading. Improve test coverage. See GitHub issue comment; thanks @LiNk-NY (v. 0.99.11) Use S4 class alphamissense_connection, extending duckdb_connection. (v. 0.99.10) Introduce visualization AlphaFold predictions. (v. 0.99.9) Update maintainer email address, add ‘Resource unavailable’ section ‘Issues & Solutions’ vignette. (v. 0.99.7) Update revised Zenodo API. (v. 0.99.5) BREAKING change. Requires duckdb >= 0.9.1, read DuckDB databases created earlier versions. Also introduces changes local cache naming. See ‘Issues & Solutions’ vignette. (v. 0.99.4) Change back Bioconductor ‘Software’ package, allow regular testing data access code. (v. 0.99.1) Change Bioconductor ‘Annotation’ package. (v. 0.99.1) Update change Zenodo API.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/news/index.html","id":"alphamissenser-0990","dir":"Changelog","previous_headings":"","what":"AlphaMissenseR 0.99.0","title":"AlphaMissenseR 0.99.0","text":"(v. 0.0.18) Rename (including updating existing tables) ‘#CHROM’ ‘CHROM’ hg19 / hg38 tables (v. 0.0.17) Initial Bioconductor submission.","code":""}]
+[{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"B. AlphaFold Integration","text":"vignette illustrates display AlphaMissense predictions AlphaFold predicted protein structure. Visualization makes use CRAN packages bio3d r3dmol. Install (necessary) Start loading AlphaMissenseR library. Visit summary available AlphaMissense datasets vignette uses aa_substitutions hg38 data resources; make sure cached locally.","code":"pkgs <- c(\"bio3d\", \"r3dmol\") pkgs_to_install <- pkgs[!pkgs %in% rownames(installed.packages())] if (length(pkgs_to_install))     BiocManager::install(pkgs_to_install) library(AlphaMissenseR) am_available() #> # A tibble: 7 × 6 #>   record   key                             size cached filename            link  #>   <chr>    <chr>                          <dbl> <lgl>  <chr>               <chr> #> 1 10813168 gene_hg38                     253636 TRUE   AlphaMissense_gene… http… #> 2 10813168 isoforms_hg38             1177361934 FALSE  AlphaMissense_isof… http… #> 3 10813168 isoforms_aa_substitutions 2461351945 FALSE  AlphaMissense_isof… http… #> 4 10813168 hg38                       642961469 TRUE   AlphaMissense_hg38… http… #> 5 10813168 hg19                       622293310 FALSE  AlphaMissense_hg19… http… #> 6 10813168 gene_hg19                     243943 FALSE  AlphaMissense_gene… http… #> 7 10813168 aa_substitutions          1207278510 TRUE   AlphaMissense_aa_s… http… am_data(\"aa_substitutions\") #> # Source:   table<aa_substitutions> [?? x 4] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>    uniprot_id protein_variant am_pathogenicity am_class   #>    <chr>      <chr>                      <dbl> <chr>      #>  1 A0A024R1R8 M1A                        0.467 ambiguous  #>  2 A0A024R1R8 M1C                        0.383 ambiguous  #>  3 A0A024R1R8 M1D                        0.827 pathogenic #>  4 A0A024R1R8 M1E                        0.524 ambiguous  #>  5 A0A024R1R8 M1F                        0.275 benign     #>  6 A0A024R1R8 M1G                        0.548 ambiguous  #>  7 A0A024R1R8 M1H                        0.552 ambiguous  #>  8 A0A024R1R8 M1I                        0.321 benign     #>  9 A0A024R1R8 M1K                        0.288 benign     #> 10 A0A024R1R8 M1L                        0.175 benign     #> # ℹ more rows am_data(\"hg38\") #> # Source:   table<hg38> [?? x 10] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr> <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr1  69094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L             #>  2 chr1  69094 G     C     hg38   Q8NH21     ENST00000335137.4 V2L             #>  3 chr1  69094 G     A     hg38   Q8NH21     ENST00000335137.4 V2M             #>  4 chr1  69095 T     C     hg38   Q8NH21     ENST00000335137.4 V2A             #>  5 chr1  69095 T     A     hg38   Q8NH21     ENST00000335137.4 V2E             #>  6 chr1  69095 T     G     hg38   Q8NH21     ENST00000335137.4 V2G             #>  7 chr1  69097 A     G     hg38   Q8NH21     ENST00000335137.4 T3A             #>  8 chr1  69097 A     C     hg38   Q8NH21     ENST00000335137.4 T3P             #>  9 chr1  69097 A     T     hg38   Q8NH21     ENST00000335137.4 T3S             #> 10 chr1  69098 C     A     hg38   Q8NH21     ENST00000335137.4 T3N             #> # ℹ more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr>"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"alphafold-protein-structure","dir":"Articles","previous_headings":"","what":"AlphaFold protein structure","title":"B. AlphaFold Integration","text":"AlphaMissense predictions pathogenicity amino acid changes can combined AlphaFold () predictions protein structure.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"fast-path","dir":"Articles","previous_headings":"AlphaFold protein structure","what":"Fast path","title":"B. AlphaFold Integration","text":"Figure 3F AlphaMissense publication visualizes mean pathogenicity UniProt id P35557. Filter amino acid data identifier visualization median pathogenicity image interactive, including rotation zoom. following sections explore visualization detail.","code":"P35557_aa <-     am_data(\"aa_substitutions\") |>     dplyr::filter(uniprot_id == \"P35557\") af_prediction_view(P35557_aa)"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"uniprot-identifiers","dir":"Articles","previous_headings":"AlphaFold protein structure","what":"UniProt identifiers","title":"B. AlphaFold Integration","text":"AlphaMissense AlphaFold use UniProt identifiers. Find AlphaMissense amino acid substitutions UniProt identifiers starting P3555; choice identifier results can compared Figure 3F AlphaMissense publication. AlphaMissenseR package includes several functions facilitate interaction AlphaFold; functions start af_*(). Use af_predictions() discover AlphaFold predictions (via AlphaFold API) associated UniProt identifiers. Note message indicating UniProt identifiers (accessions) found AlphaFold database. query returns tibble containing columns information organism UniProt characteristics (including protein sequence) , well URLs files representing three-dimensional protein structure. use pdbUrl.","code":"uniprot_ids <-     am_data(\"aa_substitutions\") |>     dplyr::filter(uniprot_id %like% \"P3555%\") |>     dplyr::distinct(uniprot_id) |>     pull(uniprot_id) uniprot_ids #> [1] \"P35555\" \"P35556\" \"P35558\" \"P35557\" prediction <- af_predictions(uniprot_ids) #> * [11:38:42][info] 2 of 4 uniprot accessions not found #>   'P35555', 'P35556' glimpse(prediction) #> Rows: 2 #> Columns: 25 #> $ entryId                <chr> \"AF-P35558-F1\", \"AF-P35557-F1\" #> $ gene                   <chr> \"PCK1\", \"GCK\" #> $ sequenceChecksum       <chr> \"78D309E0845CC181\", \"094D4A2F78096724\" #> $ sequenceVersionDate    <chr> \"2006-03-07\", \"1994-06-01\" #> $ uniprotAccession       <chr> \"P35558\", \"P35557\" #> $ uniprotId              <chr> \"PCKGC_HUMAN\", \"HXK4_HUMAN\" #> $ uniprotDescription     <chr> \"Phosphoenolpyruvate carboxykinase, cytosolic [… #> $ taxId                  <int> 9606, 9606 #> $ organismScientificName <chr> \"Homo sapiens\", \"Homo sapiens\" #> $ uniprotStart           <int> 1, 1 #> $ uniprotEnd             <int> 622, 465 #> $ uniprotSequence        <chr> \"MPPQLQNGLNLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHIC… #> $ modelCreatedDate       <chr> \"2022-06-01\", \"2022-06-01\" #> $ latestVersion          <int> 4, 4 #> $ allVersions            <list> [1, 2, 3, 4], [1, 2, 3, 4] #> $ isReviewed             <lgl> TRUE, TRUE #> $ isReferenceProteome    <lgl> TRUE, TRUE #> $ cifUrl                 <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ bcifUrl                <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ pdbUrl                 <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ paeImageUrl            <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ paeDocUrl              <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ amAnnotationsUrl       <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ amAnnotationsHg19Url   <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1… #> $ amAnnotationsHg38Url   <chr> \"https://alphafold.ebi.ac.uk/files/AF-P35558-F1…"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"protein-structure","dir":"Articles","previous_headings":"AlphaFold protein structure","what":"Protein structure","title":"B. AlphaFold Integration","text":"Focus particular UniProt identifier PDB url. Cache PDB file using BiocFileCache, read PDB file using bio3d. Visualize protein using r3dmol, using ‘cartoon’ style.","code":"pdb_url <-     prediction |>     dplyr::filter(uniprotAccession == \"P35557\") |>     dplyr::pull(pdbUrl) pdb_file <- BiocFileCache::bfcrpath(rnames = basename(pdb_url), fpath = pdb_url) pdb <- bio3d::read.pdb(pdb_file) pdb #>  #>  Call:  bio3d::read.pdb(file = pdb_file) #>  #>    Total Models#: 1 #>      Total Atoms#: 3642,  XYZs#: 10926  Chains#: 1  (values: A) #>  #>      Protein Atoms#: 3642  (residues/Calpha atoms#: 465) #>      Nucleic acid Atoms#: 0  (residues/phosphate atoms#: 0) #>  #>      Non-protein/nucleic Atoms#: 0  (residues: 0) #>      Non-protein/nucleic resid values: [ none ] #>  #>    Protein sequence: #>       MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT #>       YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE #>       MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN #>       VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMI...<cut>...MLGQ #>  #> + attr: atom, xyz, seqres, calpha, call r3dmol::r3dmol() |>     ## use the PDB representation     r3dmol::m_add_model(r3dmol::m_bio3d(pdb)) |>     ## visualize as a 'cartoon' with alpha helices and beta sheets     r3dmol::m_set_style(style = r3dmol::m_style_cartoon(arrow = TRUE)) |>     ## fit molecule into display area     r3dmol::m_zoom_to()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"average-pathogenicity","dir":"Articles","previous_headings":"AlphaFold protein structure","what":"Average pathogenicity","title":"B. AlphaFold Integration","text":"goal visualize measure ‘average’ pathogenicity three-dimensional protein structure provided AlphaFold. Start specific genome sequence (e.g., hg38). Filter amino acids UniProt region interest. chromosome position, AlphaMissense predictions contain several alternative alleles hence protein variants. (arithmetic) average pathogenicity (extremely naive computation) amino acid position ","code":"P35557 <-     am_data(\"hg38\") |>     dplyr::filter(uniprot_id == \"P35557\") pathogenicity <- am_aa_pathogenicity(P35557) pathogenicity #> # A tibble: 464 × 9 #>    uniprot_id aa_pos aa_ref aa_pathogenicity_n aa_pathogenicity_mean #>    <chr>       <int> <chr>               <int>                 <dbl> #>  1 P35557          2 L                       5                0.0818 #>  2 P35557          3 D                       8                0.184  #>  3 P35557          4 D                       8                0.147  #>  4 P35557          5 R                       6                0.250  #>  5 P35557          6 A                       6                0.138  #>  6 P35557          7 R                       7                0.257  #>  7 P35557          8 M                       9                0.142  #>  8 P35557          9 E                       7                0.212  #>  9 P35557         10 A                       6                0.142  #> 10 P35557         11 A                       6                0.142  #> # ℹ 454 more rows #> # ℹ 4 more variables: aa_pathogenicity_median <dbl>, #> #   aa_pathogenicity_min <dbl>, aa_pathogenicity_max <dbl>, #> #   aa_pathogenicity_mode <fct>"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"coloring-amino-acids-by-position","dir":"Articles","previous_headings":"AlphaFold protein structure","what":"Coloring amino acids by position","title":"B. AlphaFold Integration","text":"Individual amino acids can colored using colorfunc= argument r3dmol::m_style_cartoon(). Javascript function takes atom position returns corresponding color. approach taken AlphaMissenseR use template, ultimately replacing ... vector residue colors. function af_colorfunc_by_position() provides mechanism translating vector scores zero one vector colors. illustrated 12-amino acid sequence first last residues uncolored. following color function similar used af_prediction_view(), uses mean rather median pathogenicity scales palette minimum maximum values mean pathogenicity vector, rather 0 1. Add colorfunc= argument m_style_cartoon() visualization.","code":"cat(     AlphaMissenseR:::js_template(\"colorfunc\", colors = \"...\"),     \"\\n\" ) #> function(atom) { #>     const residue_colors = [ ... ]; #>     return residue_colors[atom.resi]; #> } df <- tibble(     pos = 1 + 1:10, # no color information for position 1     value = 10:1 / 10 ) colorfunc <- af_colorfunc_by_position(     df,     \"pos\", \"value\",     pos_max = 12    # no color information for position 12 ) cat(colorfunc, \"\\n\") #> function(atom) { #>     const residue_colors = [ 'gray', '#8E063B', '#AB5468', '#C18692', '#D2B0B6', '#DDD0D2', '#D2D3DC', '#B3B7CF', '#8C94BF', '#5D6CAE', '#023FA5', 'gray' ]; #>     return residue_colors[atom.resi]; #> } colorfunc <-     pathogenicity |>     af_colorfunc_by_position(         \"aa_pos\", \"aa_pathogenicity_mean\",         length(pdb$seqres)     ) r3dmol::r3dmol() |>     ## use the PDB representation     r3dmol::m_add_model(r3dmol::m_bio3d(pdb)) |>     ## visualize as a 'cartoon' with alpha helices and beta sheets     r3dmol::m_set_style(         style = r3dmol::m_style_cartoon(             arrow = TRUE,             ## color residue according to colorfunc             colorfunc = colorfunc         )     ) |>     ## fit molecule into display area     r3dmol::m_zoom_to()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"visualizing-genomic-tracks","dir":"Articles","previous_headings":"","what":"Visualizing genomic tracks","title":"B. AlphaFold Integration","text":"variant effect prediction data can also visualized genome browser view. allows user explore predicted pathogenicity single nucleotide missense mutations gene interest. multi-scale visualization based Gosling, grammar-based toolkit scalable interactive genomics data visualization. demonstration, create GPos object protein interest. function plot_granges invokes functionality shiny.gosling package produce interactive genome track plot pathogenicity score point mutation linear genomic track. resulting plot Shiny app can displayed running following command interactive R session. Alternatively, multiscale-lollipop plot can generated function changing plot_type argument highlight predicted class outcomes mutation (ambigious, benign, pathogenic).","code":"gpos <-     am_data(\"hg38\") |>     filter(uniprot_id == \"Q1W6H9\") |>     to_GPos() gosling_plot(     gpos, plot_type = \"bar\",     title = \"Q1W6H9 track\",     subtitle = \"bar plot example\" ) gosling_plot(     gpos, plot_type = \"lollipop\",     title = \"Q1W6H9 track\",     subtitle = \"lollipop plot example\" )"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"finally","dir":"Articles","previous_headings":"","what":"Finally","title":"B. AlphaFold Integration","text":"Remember disconnect shutdown managed DuckDB connections. Database connections closed correctly trigger warning messages.","code":"db_disconnect_all()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/alphafold.html","id":"session-information","dir":"Articles","previous_headings":"","what":"Session information","title":"B. AlphaFold Integration","text":"","code":"sessionInfo() #> R Under development (unstable) (2024-07-31 r86945) #> Platform: aarch64-apple-darwin23.4.0 #> Running under: macOS Sonoma 14.6.1 #>  #> Matrix products: default #> BLAS:   /Users/mtmorgan/bin/R-devel/lib/libRblas.dylib  #> LAPACK: /Users/mtmorgan/bin/R-devel/lib/libRlapack.dylib;  LAPACK version 3.12.0 #>  #> locale: #> [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 #>  #> time zone: America/New_York #> tzcode source: internal #>  #> attached base packages: #> [1] stats     graphics  grDevices utils     datasets  methods   base      #>  #> other attached packages: #> [1] AlphaMissenseR_1.1.5 dplyr_1.1.4          #>  #> loaded via a namespace (and not attached): #>  [1] gtable_0.3.5            xfun_0.47               bslib_0.8.0             #>  [4] ggplot2_3.5.1           htmlwidgets_1.6.4       vctrs_0.6.5             #>  [7] rjsoncons_1.3.1         tools_4.5.0             generics_0.1.3          #> [10] stats4_4.5.0            curl_5.2.3              parallel_4.5.0          #> [13] tibble_3.2.1            fansi_1.0.6             RSQLite_2.3.7           #> [16] blob_1.2.4              shiny.gosling_1.1.0     pkgconfig_2.0.3         #> [19] BiocBaseUtils_1.7.3     dbplyr_2.5.0            S4Vectors_0.43.2        #> [22] desc_1.4.3              RcppSpdlog_0.0.18       GenomeInfoDbData_1.2.12 #> [25] lifecycle_1.0.4         compiler_4.5.0          textshaping_0.4.0       #> [28] munsell_0.5.1           GenomeInfoDb_1.41.1     httpuv_1.6.15           #> [31] htmltools_0.5.8.1       sass_0.4.9              yaml_2.3.10             #> [34] later_1.3.2             pillar_1.9.0            pkgdown_2.1.0           #> [37] jquerylib_0.1.4         whisker_0.4.1           tidyr_1.3.1             #> [40] cachem_1.1.0            mime_0.12               tidyselect_1.2.1        #> [43] r3dmol_0.1.2            digest_0.6.37           duckdb_1.0.0-2          #> [46] purrr_1.0.2             fastmap_1.2.0           grid_4.5.0              #> [49] colorspace_2.1-1        cli_3.6.3               magrittr_2.0.3          #> [52] spdl_0.0.5              utf8_1.2.4              withr_3.0.1             #> [55] UCSC.utils_1.1.0        promises_1.3.0          filelock_1.0.3          #> [58] scales_1.3.0            bit64_4.0.5             XVector_0.45.0          #> [61] rmarkdown_2.28          httr_1.4.7              bit_4.0.5               #> [64] ragg_1.3.2              memoise_2.0.1           shiny_1.9.1             #> [67] evaluate_0.24.0         knitr_1.48              IRanges_2.39.2          #> [70] GenomicRanges_1.57.1    bio3d_2.4-4             BiocFileCache_2.13.0    #> [73] rlang_1.1.4             Rcpp_1.0.13             xtable_1.8-4            #> [76] glue_1.7.0              DBI_1.2.3               BiocGenerics_0.51.0     #> [79] jsonlite_1.8.9          R6_2.5.1                zlibbioc_1.51.1         #> [82] systemfonts_1.1.0       fs_1.6.4"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/clinvar.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"C. ClinVar Integration","text":"ClinVar freely available, public archive human genetic variants provides clinical classifications whether variant likely benign pathogenic. AlphaMissense publication uses ClinVar data evaluate calibrate predictions generated model. table containing ClinVar information 82872 variants across 7951 proteins derived supplemental data AlphaMissense paper, made available package benchmarking visualization purposes.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/clinvar.html","id":"access-clinvar-classifications-with-alphamissense-predictions","dir":"Articles","previous_headings":"","what":"Access ClinVar classifications with AlphaMissense predictions","title":"C. ClinVar Integration","text":"ClinVar table can accessed using clinvar_data() database. ClinVar table now available exploration parsing.","code":"clinvar_data() #> # Source:   table<clinvar> [?? x 5] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>    variant_id           transcript_id     protein_variant AlphaMissense label  #>    <chr>                <chr>             <chr>                   <dbl> <fct>  #>  1 chr1_925969_C_T_hg38 ENST00000342066.8 Q96NU1:P10S            0.967  benign #>  2 chr1_930165_G_A_hg38 ENST00000342066.8 Q96NU1:R28Q            0.663  benign #>  3 chr1_930204_G_A_hg38 ENST00000342066.8 Q96NU1:R41Q            0.0866 benign #>  4 chr1_930245_G_A_hg38 ENST00000342066.8 Q96NU1:D55N            0.134  benign #>  5 chr1_930248_G_A_hg38 ENST00000342066.8 Q96NU1:G56S            0.100  benign #>  6 chr1_930282_G_A_hg38 ENST00000342066.8 Q96NU1:R67Q            0.0635 benign #>  7 chr1_930285_G_A_hg38 ENST00000342066.8 Q96NU1:R68Q            0.0629 benign #>  8 chr1_930314_C_T_hg38 ENST00000342066.8 Q96NU1:H78Y            0.110  benign #>  9 chr1_930320_C_T_hg38 ENST00000342066.8 Q96NU1:R80C            0.0918 benign #> 10 chr1_931058_G_A_hg38 ENST00000342066.8 Q96NU1:V92M            0.196  benign #> # ℹ more rows"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/clinvar.html","id":"compare-clinvar-and-alphamissense","dir":"Articles","previous_headings":"","what":"Compare ClinVar and AlphaMissense","title":"C. ClinVar Integration","text":"section uses clinvar_plot() function generate scatterplot benchmarking comparing ClinVar classification AlphaMissense predictions. default, function takes one UniProt accession identifier, derives AlphaMissense scores am_data(\"aa_substitution\"), pulls ClinVar classifications data.frame previously obtained. Alternatively, possible pass custom AlphaMissense ClinVar table function. See function details information.  returned ggplot object overlays ClinVar classifications onto AlphaMissense predicted scores. Blue, gray, red colors represent pathogenicity classifications “likely benign”, “ambiguous”, “likely pathogenic”, respectively. Large, bolded points ClinVar variants colored according clinical classification, smaller points background AlphaMissense predictions. can note discrepancy clinically-validated annotations AlphaMissense predictions around position 50. AlphaMissense seems predict several variants region likely benign, ClinVar identifies pathogenic. ClinVar dataset exhaustive (proteins clinically-assessed), may proteins information available. case, function provide error. Remember disconnect database.","code":"clinvar_plot(uniprotId = \"P37023\") #> * [11:38:51][info] 'alphamissense_table' not provided, using default 'am_data(\"aa_substitution\")' table accessed through the AlphaMissenseR package #> * [11:38:54][info] 'clinvar_table' not provided, using default ClinVar dataset in AlphaMissenseR package db_disconnect_all()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/clinvar.html","id":"session-information","dir":"Articles","previous_headings":"","what":"Session information","title":"C. ClinVar Integration","text":"","code":"sessionInfo() #> R Under development (unstable) (2024-07-31 r86945) #> Platform: aarch64-apple-darwin23.4.0 #> Running under: macOS Sonoma 14.6.1 #>  #> Matrix products: default #> BLAS:   /Users/mtmorgan/bin/R-devel/lib/libRblas.dylib  #> LAPACK: /Users/mtmorgan/bin/R-devel/lib/libRlapack.dylib;  LAPACK version 3.12.0 #>  #> locale: #> [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 #>  #> time zone: America/New_York #> tzcode source: internal #>  #> attached base packages: #> [1] stats     graphics  grDevices utils     datasets  methods   base      #>  #> other attached packages: #> [1] AlphaMissenseR_1.1.5 dplyr_1.1.4          #>  #> loaded via a namespace (and not attached): #>  [1] tidyr_1.3.1          sass_0.4.9           utf8_1.2.4           #>  [4] generics_0.1.3       spdl_0.0.5           RSQLite_2.3.7        #>  [7] digest_0.6.37        magrittr_2.0.3       evaluate_0.24.0      #> [10] grid_4.5.0           fastmap_1.2.0        blob_1.2.4           #> [13] jsonlite_1.8.9       whisker_0.4.1        DBI_1.2.3            #> [16] httr_1.4.7           purrr_1.0.2          fansi_1.0.6          #> [19] scales_1.3.0         textshaping_0.4.0    jquerylib_0.1.4      #> [22] duckdb_1.0.0-2       cli_3.6.3            rlang_1.1.4          #> [25] dbplyr_2.5.0         munsell_0.5.1        bit64_4.0.5          #> [28] withr_3.0.1          cachem_1.1.0         yaml_2.3.10          #> [31] BiocBaseUtils_1.7.3  tools_4.5.0          memoise_2.0.1        #> [34] colorspace_2.1-1     ggplot2_3.5.1        filelock_1.0.3       #> [37] curl_5.2.3           rjsoncons_1.3.1      vctrs_0.6.5          #> [40] R6_2.5.1             BiocFileCache_2.13.0 lifecycle_1.0.4      #> [43] RcppSpdlog_0.0.18    fs_1.6.4             htmlwidgets_1.6.4    #> [46] bit_4.0.5            ragg_1.3.2           pkgconfig_2.0.3      #> [49] desc_1.4.3           pkgdown_2.1.0        pillar_1.9.0         #> [52] bslib_0.8.0          gtable_0.3.5         Rcpp_1.0.13          #> [55] glue_1.7.0           systemfonts_1.1.0    highr_0.11           #> [58] xfun_0.47            tibble_3.2.1         tidyselect_1.2.1     #> [61] knitr_1.48           farver_2.1.2         htmltools_0.5.8.1    #> [64] labeling_0.4.3       rmarkdown_2.28       compiler_4.5.0"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"A. Introduction","text":"AlphaMissense publication outlines variant AlphaFold / DeepMind used predict missense variant pathogenicity. Supporting data Zenodo include, instance 70+M variants across hg19 hg38 genome builds. AlphaMissense package allows ready access data, downloading individual files DuckDB databases ready exploration integration R Bioconductor workflows. Install package Bioconductor GitHub, ensuring correct Bioconductor dependencies. package available Bioconductor, use Use pre-release devel version Load library. Learn available data visiting Zenodo record data retrieved .","code":"if (!\"BiocManager\" %in% rownames(installed.packages()))     install.packages(\"BiocManager\", repos = \"https://cran.r-project.org\") if (BiocManager::version() >= \"3.19\") {     BiocManager::install(\"AlphaMissenseR\") } else {     stop(         \"'AlphaMissenseR' requires Bioconductor version 3.19 or later, \",         \"install from GitHub?\"     ) } remotes::install_github(     \"mtmorgan/AlphaMissenseR\",     repos = BiocManager::repositories() ) library(AlphaMissenseR) am_browse()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"discovery-retrieval-and-use","dir":"Articles","previous_headings":"","what":"Discovery, retrieval and use","title":"A. Introduction","text":"Use am_available() discover data resources available representation DuckDB databases. cached column initially FALSE data sets; TRUE indicates data set downloaded am_data(), described . available data sets use recent record 25 September, 2023; can changed specifying alternative record= argument changed globally setting environment variable ALPHAMISSENSE_RECORD loading package. Use am_data() download data resource store DuckDB database. key= argument column returned am_available(). Files cached locally (using BiocFileCache) operation expensive first time. record= stored different database. return value tbl table DuckDB database. (read-) connection database available connection remains open throughout session; call db_disconnect(db) db_disconnect_all() close end session. database contains tables key downloaded. alternative am_available() / am_data(), view available tables create dplyr / dbplyr tibble table interest. fast straight-forward summarize data, e.g., number variants assigned pathogenicity class. average pathogenicity score class… number transitions REF ALT nucleotides across variants. straight-forward select variants individual regions interest, e.g., first 200000 nucleoties chromosome 4.","code":"am_available() #> # A tibble: 7 × 6 #>   record   key                             size cached filename            link  #>   <chr>    <chr>                          <dbl> <lgl>  <chr>               <chr> #> 1 10813168 gene_hg38                     253636 TRUE   AlphaMissense_gene… http… #> 2 10813168 isoforms_hg38             1177361934 FALSE  AlphaMissense_isof… http… #> 3 10813168 isoforms_aa_substitutions 2461351945 FALSE  AlphaMissense_isof… http… #> 4 10813168 hg38                       642961469 TRUE   AlphaMissense_hg38… http… #> 5 10813168 hg19                       622293310 FALSE  AlphaMissense_hg19… http… #> 6 10813168 gene_hg19                     243943 FALSE  AlphaMissense_gene… http… #> 7 10813168 aa_substitutions          1207278510 TRUE   AlphaMissense_aa_s… http… tbl <- am_data(\"hg38\") tbl #> # Source:   table<hg38> [?? x 10] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr> <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr1  69094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L             #>  2 chr1  69094 G     C     hg38   Q8NH21     ENST00000335137.4 V2L             #>  3 chr1  69094 G     A     hg38   Q8NH21     ENST00000335137.4 V2M             #>  4 chr1  69095 T     C     hg38   Q8NH21     ENST00000335137.4 V2A             #>  5 chr1  69095 T     A     hg38   Q8NH21     ENST00000335137.4 V2E             #>  6 chr1  69095 T     G     hg38   Q8NH21     ENST00000335137.4 V2G             #>  7 chr1  69097 A     G     hg38   Q8NH21     ENST00000335137.4 T3A             #>  8 chr1  69097 A     C     hg38   Q8NH21     ENST00000335137.4 T3P             #>  9 chr1  69097 A     T     hg38   Q8NH21     ENST00000335137.4 T3S             #> 10 chr1  69098 C     A     hg38   Q8NH21     ENST00000335137.4 T3N             #> # ℹ more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr> db <- db_connect() db_tables(db) #> [1] \"aa_substitutions\" \"clinvar\"          \"gene_hg38\"        \"hg38\"  tbl <- tbl(db, \"hg38\") tbl #> # Source:   table<hg38> [?? x 10] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr> <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr1  69094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L             #>  2 chr1  69094 G     C     hg38   Q8NH21     ENST00000335137.4 V2L             #>  3 chr1  69094 G     A     hg38   Q8NH21     ENST00000335137.4 V2M             #>  4 chr1  69095 T     C     hg38   Q8NH21     ENST00000335137.4 V2A             #>  5 chr1  69095 T     A     hg38   Q8NH21     ENST00000335137.4 V2E             #>  6 chr1  69095 T     G     hg38   Q8NH21     ENST00000335137.4 V2G             #>  7 chr1  69097 A     G     hg38   Q8NH21     ENST00000335137.4 T3A             #>  8 chr1  69097 A     C     hg38   Q8NH21     ENST00000335137.4 T3P             #>  9 chr1  69097 A     T     hg38   Q8NH21     ENST00000335137.4 T3S             #> 10 chr1  69098 C     A     hg38   Q8NH21     ENST00000335137.4 T3N             #> # ℹ more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr> tbl |>     count(am_class) #> # Source:   SQL [3 x 2] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>   am_class                 n #>   <chr>                <dbl> #> 1 likely_pathogenic 22770557 #> 2 likely_benign     40917351 #> 3 ambiguous          8009648 tbl |>     group_by(am_class) |>     summarize(n = n(), pathogenecity = mean(am_pathogenicity, na.rm = TRUE)) #> # Source:   SQL [3 x 3] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>   am_class                 n pathogenecity #>   <chr>                <dbl>         <dbl> #> 1 likely_benign     40917351         0.147 #> 2 likely_pathogenic 22770557         0.863 #> 3 ambiguous          8009648         0.444 tbl |>     count(REF, ALT) |>     tidyr::pivot_wider(names_from = \"ALT\", values_from = \"n\") |>     select(\"REF\", \"A\", \"C\", \"G\", \"T\") |>     arrange(REF) #> # Source:     SQL [4 x 5] #> # Database:   DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #> # Ordered by: REF #>   REF         A       C       G       T #>   <chr>   <dbl>   <dbl>   <dbl>   <dbl> #> 1 A          NA 6420083 5449617 5953590 #> 2 C     6183248      NA 6963298 4909869 #> 3 G     4894493 6937258      NA 6161594 #> 4 T     5955039 5445540 6423927      NA tbl |>     filter(CHROM == \"chr4\", POS > 0, POS <= 200000) #> # Source:   SQL [?? x 10] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr> <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr4  59430 G     C     hg38   Q8IYB9     ENST00000610261.6 E2Q             #>  2 chr4  59430 G     A     hg38   Q8IYB9     ENST00000610261.6 E2K             #>  3 chr4  59431 A     C     hg38   Q8IYB9     ENST00000610261.6 E2A             #>  4 chr4  59431 A     G     hg38   Q8IYB9     ENST00000610261.6 E2G             #>  5 chr4  59431 A     T     hg38   Q8IYB9     ENST00000610261.6 E2V             #>  6 chr4  59432 A     C     hg38   Q8IYB9     ENST00000610261.6 E2D             #>  7 chr4  59432 A     T     hg38   Q8IYB9     ENST00000610261.6 E2D             #>  8 chr4  59433 C     A     hg38   Q8IYB9     ENST00000610261.6 L3I             #>  9 chr4  59433 C     T     hg38   Q8IYB9     ENST00000610261.6 L3F             #> 10 chr4  59433 C     G     hg38   Q8IYB9     ENST00000610261.6 L3V             #> # ℹ more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr>"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"working-with-bioconductor","dir":"Articles","previous_headings":"","what":"Working with Bioconductor","title":"A. Introduction","text":"section illustrates AlphaMissense data can integrated Bioconductor workflows, including GenomicRanges infrastructure ensembldb package / AnnotationHub resources.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"genomic-ranges","dir":"Articles","previous_headings":"Working with Bioconductor","what":"Genomic ranges","title":"A. Introduction","text":"GenomicRanges infrastructure provides standard data structures allow range-based operations across Bioconductor packages. GPos data structure provides convenient memory-efficient representation single-nucleotide variants like hg19 hg38 AlphaMissense resources. Start installing (necessary) GenomicRanges package. Select hg38 data resource, filter subset variants; GPos -memory data structure can easily manage 10’s millions variants. Use to_GPos() coerce GPos object. Vignettes GenomicRanges package illustrate use objects.","code":"if (!requireNamespace(\"GenomicRanges\", quietly = TRUE))     BiocManager::install(\"GenomicRanges\") tbl <-     am_data(\"hg38\") |>     filter(CHROM == \"chr2\", POS < 10000000, REF == \"G\") gpos <-     tbl |>     to_GPos() gpos #> UnstitchedGPos object with 26751 positions and 7 metadata columns: #>           seqnames       pos strand |         REF         ALT  uniprot_id #>              <Rle> <integer>  <Rle> | <character> <character> <character> #>       [1]     chr2     41613      * |           G           C      Q1W6H9 #>       [2]     chr2     41615      * |           G           C      Q1W6H9 #>       [3]     chr2     41615      * |           G           A      Q1W6H9 #>       [4]     chr2     41615      * |           G           T      Q1W6H9 #>       [5]     chr2     41618      * |           G           C      Q1W6H9 #>       ...      ...       ...    ... .         ...         ...         ... #>   [26747]     chr2   9999028      * |           G           A      Q9NZI5 #>   [26748]     chr2   9999028      * |           G           T      Q9NZI5 #>   [26749]     chr2   9999029      * |           G           C      Q9NZI5 #>   [26750]     chr2   9999029      * |           G           A      Q9NZI5 #>   [26751]     chr2   9999029      * |           G           T      Q9NZI5 #>                transcript_id protein_variant am_pathogenicity          am_class #>                  <character>     <character>        <numeric>       <character> #>       [1]  ENST00000327669.5           R321G           0.0848     likely_benign #>       [2]  ENST00000327669.5           S320C           0.0946     likely_benign #>       [3]  ENST00000327669.5           S320F           0.1593     likely_benign #>       [4]  ENST00000327669.5           S320Y           0.1429     likely_benign #>       [5]  ENST00000327669.5           P319R           0.0765     likely_benign #>       ...                ...             ...              ...               ... #>   [26747] ENST00000324907.14           G581R           0.9997 likely_pathogenic #>   [26748] ENST00000324907.14           G581W           0.9996 likely_pathogenic #>   [26749] ENST00000324907.14           G581A           0.9970 likely_pathogenic #>   [26750] ENST00000324907.14           G581E           0.9995 likely_pathogenic #>   [26751] ENST00000324907.14           G581V           0.9994 likely_pathogenic #>   ------- #>   seqinfo: 25 sequences (1 circular) from hg38 genome utils::browseVignettes(\"GenomicRanges\")"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"grch38-annotation-resources","dir":"Articles","previous_headings":"Working with Bioconductor","what":"GRCh38 annotation resources","title":"A. Introduction","text":"Start identifying recent EnsDb resource Homo Sapiens. Load ensembldb library retrieve record. Unfortunately, many conflicts function names different packages, becomes necessary fully resolve functions package defined.","code":"hub <- AnnotationHub::AnnotationHub() AnnotationHub::query(hub, c(\"EnsDb\", \"Homo sapiens\")) #> AnnotationHub with 27 records #> # snapshotDate(): 2024-08-01 #> # $dataprovider: Ensembl #> # $species: Homo sapiens #> # $rdataclass: EnsDb #> # additional mcols(): taxonomyid, genome, description, #> #   coordinate_1_based, maintainer, rdatadateadded, preparerclass, tags, #> #   rdatapath, sourceurl, sourcetype  #> # retrieve records with, e.g., 'object[[\"AH53211\"]]'  #>  #>              title                              #>   AH53211  | Ensembl 87 EnsDb for Homo Sapiens  #>   AH53715  | Ensembl 88 EnsDb for Homo Sapiens  #>   AH56681  | Ensembl 89 EnsDb for Homo Sapiens  #>   AH57757  | Ensembl 90 EnsDb for Homo Sapiens  #>   AH60773  | Ensembl 91 EnsDb for Homo Sapiens  #>   ...        ...                                #>   AH109336 | Ensembl 108 EnsDb for Homo sapiens #>   AH109606 | Ensembl 109 EnsDb for Homo sapiens #>   AH113665 | Ensembl 110 EnsDb for Homo sapiens #>   AH116291 | Ensembl 111 EnsDb for Homo sapiens #>   AH116860 | Ensembl 112 EnsDb for Homo sapiens  AnnotationHub::AnnotationHub()[\"AH113665\"] #> AnnotationHub with 1 record #> # snapshotDate(): 2024-08-01 #> # names(): AH113665 #> # $dataprovider: Ensembl #> # $species: Homo sapiens #> # $rdataclass: EnsDb #> # $rdatadateadded: 2023-04-25 #> # $title: Ensembl 110 EnsDb for Homo sapiens #> # $description: Gene and protein annotations for Homo sapiens based on Ensem... #> # $taxonomyid: 9606 #> # $genome: GRCh38 #> # $sourcetype: ensembl #> # $sourceurl: http://www.ensembl.org #> # $sourcesize: NA #> # $tags: c(\"110\", \"Annotation\", \"AnnotationHubSoftware\", \"Coverage\", #> #   \"DataImport\", \"EnsDb\", \"Ensembl\", \"Gene\", \"Protein\", \"Sequencing\", #> #   \"Transcript\")  #> # retrieve record with 'object[[\"AH113665\"]]' library(ensembldb) edb <- AnnotationHub::AnnotationHub()[[\"AH113665\"]] edb #> EnsDb for Ensembl: #> |Backend: SQLite #> |Db type: EnsDb #> |Type of Gene ID: Ensembl Gene ID #> |Supporting package: ensembldb #> |Db created by: ensembldb package from Bioconductor #> |script_version: 0.3.10 #> |Creation time: Mon Aug  7 09:02:07 2023 #> |ensembl_version: 110 #> |ensembl_host: 127.0.0.1 #> |Organism: Homo sapiens #> |taxonomy_id: 9606 #> |genome_build: GRCh38 #> |DBSCHEMAVERSION: 2.2 #> |common_name: human #> |species: homo_sapiens #> | No. of genes: 71440. #> | No. of transcripts: 278545. #> |Protein data available."},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"from-bioconductor-to-duckdb","dir":"Articles","previous_headings":"Working with Bioconductor","what":"From Bioconductor to DuckDB","title":"A. Introduction","text":"section work directly database, including writing temporary tables. illustration purposes, use connection can read write; practice, read-permissions sufficient creating temporary tables. illustration, use ensembldb identify exons canonical transcript particular gene. Munge data tibble, updating seqnames column CHROM identifiers \"chr1\" (AlphaMissense data). Write tibble temporary table (deleted db disconnected database) can used ‘lazy’ SQL queries AlphaMissense data. temporary table now available db_rw connection; tables removed disconnect, db_disconnect(db_rw). Use db_range_join() join AlphaMissense data ranges defining exons gene interest. arguments database connection, AlphaMissense table interest (table must columns CHROM POS), table containing ranges interest (columns CHROM, start, end), temporary table contain results. range join like standard database join, expect constraints can relations, case POS >= start POS <= end range interest; implementation details DuckDB blog. range join uses closed intervals (start end positions included query), following Bioconductor convention. Writing temporary table avoids bringing potentially large datasets R memory, makes table available subsequent manipulation current session. query takes place almost instantly. larger query 71M variants 1000 ranges took 20 seconds. usual database dplyr verbs can used summarize results, e.g., number variants pathogenecity class exon. perhaps instructive review range join source inspiration computations might interest. best practice, disconnect writable database connection work complete.","code":"db_rw <- db_connect(read_only = FALSE) bcl2l11 <-     edb |>     ensembldb::filter(         ~ symbol == \"BCL2L11\" &             tx_biotype == \"protein_coding\" &             tx_is_canonical == TRUE     ) |>     exonsBy(\"tx\") bcl2l11 #> GRangesList object of length 1: #> $ENST00000393256 #> GRanges object with 4 ranges and 2 metadata columns: #>       seqnames              ranges strand |         exon_id exon_rank #>          <Rle>           <IRanges>  <Rle> |     <character> <integer> #>   [1]        2 111120914-111121188      + | ENSE00004011574         1 #>   [2]        2 111123733-111124139      + | ENSE00001008808         2 #>   [3]        2 111150044-111150147      + | ENSE00003483971         3 #>   [4]        2 111164133-111168444      + | ENSE00001924953         4 #>   ------- #>   seqinfo: 1 sequence from GRCh38 genome bcl2l11_tbl <-     bcl2l11 |>     dplyr::as_tibble() |>     dplyr::mutate(CHROM = paste0(\"chr\", seqnames)) |>     dplyr::select(CHROM, everything(), -seqnames)  db_temporary_table(db_rw, bcl2l11_tbl, \"bcl2l11\") #> # Source:   table<bcl2l11> [4 x 9] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>   CHROM group group_name          start       end width strand exon_id exon_rank #>   <chr> <int> <chr>               <int>     <int> <int> <fct>  <chr>       <int> #> 1 chr2      1 ENST00000393256 111120914 111121188   275 +      ENSE00…         1 #> 2 chr2      1 ENST00000393256 111123733 111124139   407 +      ENSE00…         2 #> 3 chr2      1 ENST00000393256 111150044 111150147   104 +      ENSE00…         3 #> 4 chr2      1 ENST00000393256 111164133 111168444  4312 +      ENSE00…         4 \"bcl2l11\" %in% db_tables(db_rw) #> [1] TRUE rng <- db_range_join(db_rw, \"hg38\", \"bcl2l11\", \"bcl2l11_overlaps\") rng #> # Source:   table<bcl2l11_overlaps> [?? x 18] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>    CHROM       POS REF   ALT   genome uniprot_id transcript_id   protein_variant #>    <chr>     <dbl> <chr> <chr> <chr>  <chr>      <chr>           <chr>           #>  1 chr2  111164133 G     A     hg38   O43521     ENST0000039325… V167I           #>  2 chr2  111164133 G     T     hg38   O43521     ENST0000039325… V167L           #>  3 chr2  111164133 G     C     hg38   O43521     ENST0000039325… V167L           #>  4 chr2  111164134 T     C     hg38   O43521     ENST0000039325… V167A           #>  5 chr2  111164134 T     A     hg38   O43521     ENST0000039325… V167E           #>  6 chr2  111164134 T     G     hg38   O43521     ENST0000039325… V167G           #>  7 chr2  111164136 T     A     hg38   O43521     ENST0000039325… F168I           #>  8 chr2  111164136 T     C     hg38   O43521     ENST0000039325… F168L           #>  9 chr2  111164136 T     G     hg38   O43521     ENST0000039325… F168V           #> 10 chr2  111164137 T     G     hg38   O43521     ENST0000039325… F168C           #> # ℹ more rows #> # ℹ 10 more variables: am_pathogenicity <dbl>, am_class <chr>, group <int>, #> #   group_name <chr>, start <int>, end <int>, width <int>, strand <fct>, #> #   exon_id <chr>, exon_rank <int> rng |>     dplyr::count(exon_id, am_class) |>     tidyr::pivot_wider(names_from = \"am_class\", values_from = \"n\") #> # Source:   SQL [3 x 4] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>   exon_id         likely_benign likely_pathogenic ambiguous #>   <chr>                   <dbl>             <dbl>     <dbl> #> 1 ENSE00001924953           172                16        19 #> 2 ENSE00001008808           494               257       108 #> 3 ENSE00003483971           128                71        33 -- range join of 'hg38' with 'bcl2l11'; overwrite any existing table -- 'bcl2l11_overlaps' DROP TABLE IF EXISTS bcl2l11_overlaps; CREATE TEMP TABLE bcl2l11_overlaps AS SELECT     hg38.*,     bcl2l11.* EXCLUDE (CHROM) FROM hg38 JOIN bcl2l11     ON bcl2l11.CHROM = hg38.CHROM     AND bcl2l11.start <= hg38.POS     AND bcl2l11.end >= hg38.POS; db_disconnect(db_rw)"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"from-duckdb-to-bioconductor","dir":"Articles","previous_headings":"Working with Bioconductor","what":"From DuckDB to Bioconductor","title":"A. Introduction","text":"likely straight-forward ways performing query previous section, e.g., filtering hg38 relevant transcript id(s), retrieving R, working edb classify variants exon. transcript interested \"ENST00000393256\". Select relevant variants , many, load R. Coerce AlphaMissense data GRanges::GPos object. One can use GenomicRanges functionality, e.g., count number variants exon.","code":"variants_of_interest <-     am_data(\"hg38\") |>     dplyr::filter(transcript_id %like% \"ENST00000393256%\") gpos <-     variants_of_interest |>     to_GPos() ## make gpos 'genome' and 'seqlevels' like bcl2l11 GenomeInfoDb::genome(gpos) <- \"GRCh38\" GenomeInfoDb::seqlevelsStyle(gpos) <- \"Ensembl\" gpos #> UnstitchedGPos object with 1298 positions and 7 metadata columns: #>          seqnames       pos strand |         REF         ALT  uniprot_id #>             <Rle> <integer>  <Rle> | <character> <character> <character> #>      [1]        2 111123749      * |           G           C      O43521 #>      [2]        2 111123749      * |           G           T      O43521 #>      [3]        2 111123749      * |           G           A      O43521 #>      [4]        2 111123750      * |           C           A      O43521 #>      [5]        2 111123750      * |           C           G      O43521 #>      ...      ...       ...    ... .         ...         ...         ... #>   [1294]        2 111164227      * |           A           G      O43521 #>   [1295]        2 111164227      * |           A           T      O43521 #>   [1296]        2 111164227      * |           A           C      O43521 #>   [1297]        2 111164228      * |           T           A      O43521 #>   [1298]        2 111164228      * |           T           G      O43521 #>              transcript_id protein_variant am_pathogenicity          am_class #>                <character>     <character>        <numeric>       <character> #>      [1] ENST00000393256.8             A2P           0.6610 likely_pathogenic #>      [2] ENST00000393256.8             A2S           0.3398     likely_benign #>      [3] ENST00000393256.8             A2T           0.7219 likely_pathogenic #>      [4] ENST00000393256.8             A2E           0.7283 likely_pathogenic #>      [5] ENST00000393256.8             A2G           0.3883         ambiguous #>      ...               ...             ...              ...               ... #>   [1294] ENST00000393256.8           H198R           0.1226     likely_benign #>   [1295] ENST00000393256.8           H198L           0.2526     likely_benign #>   [1296] ENST00000393256.8           H198P           0.1323     likely_benign #>   [1297] ENST00000393256.8           H198Q           0.1781     likely_benign #>   [1298] ENST00000393256.8           H198Q           0.1781     likely_benign #>   ------- #>   seqinfo: 25 sequences (1 circular) from GRCh38 genome countOverlaps(unlist(bcl2l11), gpos) #> ENST00000393256 ENST00000393256 ENST00000393256 ENST00000393256  #>               0             859             232             207"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"finally","dir":"Articles","previous_headings":"","what":"Finally","title":"A. Introduction","text":"Remember disconnect shutdown managed DuckDB connections. Database connections closed correctly trigger warning messages.","code":"db_disconnect_all()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/introduction.html","id":"session-information","dir":"Articles","previous_headings":"","what":"Session information","title":"A. Introduction","text":"","code":"sessionInfo() #> R Under development (unstable) (2024-07-31 r86945) #> Platform: aarch64-apple-darwin23.4.0 #> Running under: macOS Sonoma 14.6.1 #>  #> Matrix products: default #> BLAS:   /Users/mtmorgan/bin/R-devel/lib/libRblas.dylib  #> LAPACK: /Users/mtmorgan/bin/R-devel/lib/libRlapack.dylib;  LAPACK version 3.12.0 #>  #> locale: #> [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 #>  #> time zone: America/New_York #> tzcode source: internal #>  #> attached base packages: #> [1] stats4    stats     graphics  grDevices utils     datasets  methods   #> [8] base      #>  #> other attached packages: #>  [1] ensembldb_2.29.1        AnnotationFilter_1.29.0 GenomicFeatures_1.57.0  #>  [4] AnnotationDbi_1.67.0    Biobase_2.65.1          GenomicRanges_1.57.1    #>  [7] GenomeInfoDb_1.41.1     IRanges_2.39.2          S4Vectors_0.43.2        #> [10] BiocGenerics_0.51.0     AlphaMissenseR_1.1.5    dplyr_1.1.4             #>  #> loaded via a namespace (and not attached): #>  [1] DBI_1.2.3                   bitops_1.0-8                #>  [3] rlang_1.1.4                 magrittr_2.0.3              #>  [5] matrixStats_1.3.0           compiler_4.5.0              #>  [7] RSQLite_2.3.7               png_0.1-8                   #>  [9] systemfonts_1.1.0           vctrs_0.6.5                 #> [11] ProtGenerics_1.37.1         pkgconfig_2.0.3             #> [13] crayon_1.5.3                fastmap_1.2.0               #> [15] dbplyr_2.5.0                XVector_0.45.0              #> [17] utf8_1.2.4                  Rsamtools_2.21.1            #> [19] rmarkdown_2.28              UCSC.utils_1.1.0            #> [21] ragg_1.3.2                  purrr_1.0.2                 #> [23] bit_4.0.5                   xfun_0.47                   #> [25] zlibbioc_1.51.1             cachem_1.1.0                #> [27] jsonlite_1.8.9              blob_1.2.4                  #> [29] DelayedArray_0.31.11        BiocParallel_1.39.0         #> [31] parallel_4.5.0              spdl_0.0.5                  #> [33] R6_2.5.1                    bslib_0.8.0                 #> [35] rtracklayer_1.65.0          jquerylib_0.1.4             #> [37] Rcpp_1.0.13                 SummarizedExperiment_1.35.1 #> [39] knitr_1.48                  BiocBaseUtils_1.7.3         #> [41] Matrix_1.7-0                tidyselect_1.2.1            #> [43] abind_1.4-5                 yaml_2.3.10                 #> [45] codetools_0.2-20            curl_5.2.3                  #> [47] rjsoncons_1.3.1             lattice_0.22-6              #> [49] tibble_3.2.1                withr_3.0.1                 #> [51] KEGGREST_1.45.1             evaluate_0.24.0             #> [53] desc_1.4.3                  BiocFileCache_2.13.0        #> [55] Biostrings_2.73.1           pillar_1.9.0                #> [57] BiocManager_1.30.23         filelock_1.0.3              #> [59] MatrixGenerics_1.17.0       whisker_0.4.1               #> [61] generics_0.1.3              RCurl_1.98-1.16             #> [63] BiocVersion_3.20.0          ggplot2_3.5.1               #> [65] munsell_0.5.1               scales_1.3.0                #> [67] glue_1.7.0                  lazyeval_0.2.2              #> [69] tools_4.5.0                 AnnotationHub_3.13.3        #> [71] BiocIO_1.15.2               GenomicAlignments_1.41.0    #> [73] fs_1.6.4                    XML_3.99-0.17               #> [75] grid_4.5.0                  tidyr_1.3.1                 #> [77] colorspace_2.1-1            GenomeInfoDbData_1.2.12     #> [79] RcppSpdlog_0.0.18           duckdb_1.0.0-2              #> [81] restfulr_0.0.15             cli_3.6.3                   #> [83] rappdirs_0.3.3              textshaping_0.4.0           #> [85] fansi_1.0.6                 S4Arrays_1.5.7              #> [87] gtable_0.3.5                sass_0.4.9                  #> [89] digest_0.6.37               SparseArray_1.5.31          #> [91] rjson_0.2.22                htmlwidgets_1.6.4           #> [93] memoise_2.0.1               htmltools_0.5.8.1           #> [95] pkgdown_2.1.0               lifecycle_1.0.4             #> [97] httr_1.4.7                  mime_0.12                   #> [99] bit64_4.0.5"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/issues.html","id":"updating-duckdb-to-0-9-1","dir":"Articles","previous_headings":"","what":"Updating duckdb to 0.9.1","title":"D. Issues & Solutions","text":"R duckdb client version 0.9.1 read databases created previous versions package. duckdb error message indicates am_available() Error h(simpleError(msg, call)) : error evaluating argument ‘drv’ selecting method function ‘dbConnect’: rapi_startup: Failed open database: IO Error: Trying read database file version number 51, can read version 64. database file created DuckDB version v0.8.0 v0.8.1. storage DuckDB yet stable; newer versions DuckDB read old database files vice versa. storage stabilized version 1.0 releases. now, recommend load database file supported version DuckDB, use EXPORT DATABASE command followed IMPORT DATABASE current version DuckDB. See storage page information: https://duckdb.org/internals/storage practice straight-forward solution remove existing AlphaMissenseR data resources ‘start ’. following attempts identify AlphaMissenseR data resources cached locally verifying resources created outside AlphaMissenseR, remove . Commands am_available() report files cached. command re-download file insert database functions duckdb 0.9.1.","code":"am_rids <-     bfcinfo() |>     dplyr::filter(         grepl(\"zenodo\", rname) |         startsWith(rname, \"AlphaMissense_\")     ) |>     pull(rid) BiocFileCache::bfcremove(rids = am_rids) am_data(\"gene_hg38\") #> # Source:   table<gene_hg38> [?? x 2] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>    transcript_id      mean_am_pathogenicity #>    <chr>                              <dbl> #>  1 ENST00000000233.10                 0.742 #>  2 ENST00000000412.8                  0.378 #>  3 ENST00000001008.6                  0.422 #>  4 ENST00000001146.6                  0.467 #>  5 ENST00000002125.9                  0.351 #>  6 ENST00000002165.11                 0.406 #>  7 ENST00000002501.10                 0.320 #>  8 ENST00000002596.6                  0.471 #>  9 ENST00000002829.8                  0.524 #> 10 ENST00000003084.10                 0.405 #> # ℹ more rows"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/issues.html","id":"resource-temporarily-unavailable","dir":"Articles","previous_headings":"","what":"Resource temporarily unavailable","title":"D. Issues & Solutions","text":"Trying access data resource am_data() may sometimes result DuckDB errors “Resource unavailable”. occures database used independent R process. solution identify process disconnect database using, e.g., db_disconnect_all().","code":"> am_data(\"hg38\")  * [10:05:09][warning] error in evaluating the argument 'drv' in selecting a     method for function 'dbConnect': rapi_startup: Failed to open database:     IO Error: Could not set lock on file      \".../Caches/org.R-project.R/R/BiocFileCache/1ec5157ddaa2_1ec5157ddaa2\":     Resource unavailable  Error in value[[3L]](cond) :     failed to connect to DuckDB database, see 'Issues & Solutions' vignette"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/issues.html","id":"finally","dir":"Articles","previous_headings":"","what":"Finally","title":"D. Issues & Solutions","text":"Remember disconnect shutdown managed DuckDB connections. Database connections closed correctly trigger warning messages.","code":"db_disconnect_all()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/articles/issues.html","id":"session-information","dir":"Articles","previous_headings":"","what":"Session information","title":"D. Issues & Solutions","text":"","code":"sessionInfo() #> R Under development (unstable) (2024-07-31 r86945) #> Platform: aarch64-apple-darwin23.4.0 #> Running under: macOS Sonoma 14.6.1 #>  #> Matrix products: default #> BLAS:   /Users/mtmorgan/bin/R-devel/lib/libRblas.dylib  #> LAPACK: /Users/mtmorgan/bin/R-devel/lib/libRlapack.dylib;  LAPACK version 3.12.0 #>  #> locale: #> [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8 #>  #> time zone: America/New_York #> tzcode source: internal #>  #> attached base packages: #> [1] stats     graphics  grDevices utils     datasets  methods   base      #>  #> other attached packages: #> [1] AlphaMissenseR_1.1.5 dplyr_1.1.4          #>  #> loaded via a namespace (and not attached): #>  [1] sass_0.4.9           utf8_1.2.4           generics_0.1.3       #>  [4] spdl_0.0.5           RSQLite_2.3.7        digest_0.6.37        #>  [7] magrittr_2.0.3       evaluate_0.24.0      grid_4.5.0           #> [10] fastmap_1.2.0        blob_1.2.4           jsonlite_1.8.9       #> [13] whisker_0.4.1        DBI_1.2.3            httr_1.4.7           #> [16] purrr_1.0.2          fansi_1.0.6          scales_1.3.0         #> [19] textshaping_0.4.0    jquerylib_0.1.4      duckdb_1.0.0-2       #> [22] cli_3.6.3            rlang_1.1.4          dbplyr_2.5.0         #> [25] munsell_0.5.1        bit64_4.0.5          withr_3.0.1          #> [28] cachem_1.1.0         yaml_2.3.10          BiocBaseUtils_1.7.3  #> [31] tools_4.5.0          memoise_2.0.1        colorspace_2.1-1     #> [34] ggplot2_3.5.1        filelock_1.0.3       curl_5.2.3           #> [37] rjsoncons_1.3.1      vctrs_0.6.5          R6_2.5.1             #> [40] BiocFileCache_2.13.0 lifecycle_1.0.4      RcppSpdlog_0.0.18    #> [43] fs_1.6.4             htmlwidgets_1.6.4    bit_4.0.5            #> [46] ragg_1.3.2           pkgconfig_2.0.3      desc_1.4.3           #> [49] pkgdown_2.1.0        pillar_1.9.0         bslib_0.8.0          #> [52] gtable_0.3.5         Rcpp_1.0.13          glue_1.7.0           #> [55] systemfonts_1.1.0    xfun_0.47            tibble_3.2.1         #> [58] tidyselect_1.2.1     knitr_1.48           htmltools_0.5.8.1    #> [61] rmarkdown_2.28       compiler_4.5.0"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Martin Morgan. Author, maintainer. Tram Nguyen. Author. Tyrone Lee. Contributor. Nitesh Turaga. Contributor. Chan Zuckerberg Initiative DAF CZF2019-002443. Funder. NIH NCI ITCR U24CA180996. Funder. NIH NCI IOTN U24CA232979. Funder. NIH NCI ARTNet U24CA274159. Funder.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Morgan M, Nguyen T (2024). AlphaMissenseR: Accessing AlphaMissense Data Resources R. R package version 1.1.6, https://mtmorgan.github.io/AlphaMissenseR/.","code":"@Manual{,   title = {AlphaMissenseR: Accessing AlphaMissense Data Resources in R},   author = {Martin Morgan and Tram Nguyen},   year = {2024},   note = {R package version 1.1.6},   url = {https://mtmorgan.github.io/AlphaMissenseR/}, }"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/index.html","id":"alphamissense-data-for-r--bioconductor","dir":"","previous_headings":"","what":"Accessing AlphaMissense Data Resources in R","title":"Accessing AlphaMissense Data Resources in R","text":"AlphaMissense publication outlines variant AlphaFold / DeepMind used predict missense variant pathogenicity. Supporting data Zenodo include, instance 70+M variants across hg19 hg38 genome builds. AlphaMissense package allows ready access data, downloading individual files DuckDB databases ready exploration integration R Bioconductor worksflows.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"Accessing AlphaMissense Data Resources in R","text":"Install package Bioconductor GitHub, ensuring correct Bioconductor dependencies. package available Bioconductor, use Use pre-release devel version Load library.","code":"if (!\"BiocManager\" %in% rownames(installed.packages()))     install.packages(\"BiocManager\", repos = \"https://cloud.R-project.org\") if (BiocManager::version() >= \"3.19\") {     BiocManager::install(\"AlphaMissenseR\") } else {     stop(         \"'AlphaMissenseR' requires Bioconductor version 3.19 or later, \",         \"install from GitHub?\"     ) } if (!\"remotes\" %in% rownames(installed.packages()))     install.packages(\"remotes\", repos = \"https://cloud.R-project.org\") remotes::install_github(     \"mtmorgan/AlphaMissenseR\",     repos = BiocManager::repositories() ) library(AlphaMissenseR)"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/index.html","id":"next-steps","dir":"","previous_headings":"","what":"Next steps","title":"Accessing AlphaMissense Data Resources in R","text":"Visit Introduction learn accessing AlphaMissense data R. AlphaFold Integration article shows missense effects can plotted AlphaFold () protein structures. Use ClinVar Integration compare AlphaMissense ClinVar predictions. Troubleshoot common problems Issues & Solutions.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html","id":null,"dir":"Reference","previous_headings":"","what":"AlphaFold Protein Structure Retrieval and Display — af_predictions","title":"AlphaFold Protein Structure Retrieval and Display — af_predictions","text":"af_predictions() retrieves information AlphaFold predictions associated UniProt accession identifiers. af_prediction_view() summarizes effects possible amino acid changes single UniProt protein. changes displayed AlphaFold-predicted structure. af_colorfunc_by_position() generates Javascript function used rd3mol::m_set_style() color residues position, e.g., visualizing median predicted pathogenicity.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"AlphaFold Protein Structure Retrieval and Display — af_predictions","text":"","code":"af_predictions(uniprot_ids)  af_prediction_view(tbl, bfc = BiocFileCache())  af_colorfunc_by_position(     tbl,     pos,     value,     pos_max = NULL,     palette = colorspace::diverging_hcl(11),     palette_min = NULL,     palette_max = NULL )"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"AlphaFold Protein Structure Retrieval and Display — af_predictions","text":"uniprot_ids character() UniProt accession identifiers (uniprot_id AlphaMissense tables). tbl tibble containing information UniProt protein AlphaMissense predicted amino acid effects. av_prediction_view() tibble must columns uniprot_id, protein_variant, am_pathogenicity, am_class, tibbles returned am_data(\"hg38\") am_data(\"aa_substitutions\"), instance. uniprot_id must contain single unique value. af_colorfunc_by_position() tibble must columns pos value, described . bfc object created BiocFileCache::BiocFileCache(), representing location used cache PDB files retrieved av_prediction_view(). default BiocFileCache installation-wide location. pos symbol name column tbl containing amino acid residue positions protein. value symbol name column tbl containing values used coloring amino acid residues protein. pos_max integer(1) maximum residue position protein visualized. Default: maximum value pos. palette character() vector colors used visualization. default (colorspace::diverging_hcl(11)) produces colors ranging blue (low) red (high). palette_min numeric(1) value bounding minimum palette color. default minimum value; common value plotting pathogenicity might 0. palette_max numeric(1) value bounding maximum palette color. default maximum value; common value plotting pathogenicity might 1.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"AlphaFold Protein Structure Retrieval and Display — af_predictions","text":"af_predictions() returns tibble. row represents AlphaFold prediction associated corresponding uniprot accession. Columns include: entryId: AlphaFold identifier. gene: gene symbol corresponding UniProt protein. uniprotAccession, uniprotId, uniprotDescription: UniProt characterization. AlphaMissense's uniprot_id AlphaFold's uniprotAccession. taxId, organismScientificName: Organism information. uniprotStart, uniprotEnd, uniprotSequence: protein sequence information. modelCreatedDate, latestVersion, allVersions, isReviewed, isReferenceProteome: AlphaFold provenance information. cifUrl, bcifUrl, pdbUrl: URLs AlphaFold 3-dimensional molecular representations. paeImageUrl, paeDocUrl: 'Predicted Aligned Error' heat map underlying data. can used assess confidence relative orientation residues different domains, described part AlphaFold FAQ https://alphafold.ebi.ac.uk/faq af_prediction_view() displays interactive view protein RStudio panel browser tab. af_colorfunc_by_position() returns character(1) vector representation Javascript function, color vector injected.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"AlphaFold Protein Structure Retrieval and Display — af_predictions","text":"af_predictions() queries prediction endpoint AlphaFold API described https://alphafold.ebi.ac.uk/api-docs. af_prediction_view() uses tbl calculate median pathogenicity amino acid position, using am_aa_pathogenicity(). Predicted protein structure retrieved unique uniprot_id using af_predictions() pdbUrl returned function. Protein structure visualized using r3dmol https://cran.R-project.org/package=r3dmol package. Amino acids colored using aa_pathogenicity_median af_colorfunc_by_position() default palette defined interval 0, 1. af_colorfunc_by_position() uses template mechanism inject vector position-specific colors Javascript function used r3dmol::m_set_style() / r3dmol::m_style_cartoon() color residues position. Positions color specified colored 'gray'. template can seen AlphaMissenseR:::js_template(\"colorfunc\").","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaFold.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"AlphaFold Protein Structure Retrieval and Display — af_predictions","text":"","code":"## af_predictions  uniprot_ids <-     am_data(\"aa_substitutions\") |>     dplyr::filter(uniprot_id %like% \"P3555%\") |>     dplyr::distinct(uniprot_id) |>     pull(uniprot_id) af_predictions(uniprot_ids) #> * [11:38:15][info] 2 of 4 uniprot accessions not found #>   'P35556', 'P35555' #> # A tibble: 2 × 25 #>   entryId  gene  sequenceChecksum sequenceVersionDate uniprotAccession uniprotId #>   <chr>    <chr> <chr>            <chr>               <chr>            <chr>     #> 1 AF-P355… PCK1  78D309E0845CC181 2006-03-07          P35558           PCKGC_HU… #> 2 AF-P355… GCK   094D4A2F78096724 1994-06-01          P35557           HXK4_HUM… #> # ℹ 19 more variables: uniprotDescription <chr>, taxId <int>, #> #   organismScientificName <chr>, uniprotStart <int>, uniprotEnd <int>, #> #   uniprotSequence <chr>, modelCreatedDate <chr>, latestVersion <int>, #> #   allVersions <list>, isReviewed <lgl>, isReferenceProteome <lgl>, #> #   cifUrl <chr>, bcifUrl <chr>, pdbUrl <chr>, paeImageUrl <chr>, #> #   paeDocUrl <chr>, amAnnotationsUrl <chr>, amAnnotationsHg19Url <chr>, #> #   amAnnotationsHg38Url <chr>   ## af_prediction_view()  P35557 <-     am_data(\"hg38\") |>     dplyr::filter(uniprot_id == \"P35557\") af_prediction_view(P35557)  {\"x\":{\"id\":\"ac96cb3ee4656e2e9ec3\",\"configs\":{\"nomouse\":false,\"backgroundColor\":\"white\",\"cartoonQuality\":5,\"lowerZoomLimit\":5,\"upperZoomLimit\":400,\"antialias\":true,\"orthographic\":false,\"disableFog\":false},\"api\":[{\"method\":\"addModel\",\"data\":[\"ATOM      1  N   MET A   1      37.762  17.693 -31.307  1.00 60.70           N  \\nATOM      2  CA  MET A   1      37.985  16.974 -30.030  1.00 60.70           C  \\nATOM      3  C   MET A   1      37.126  17.503 -28.884  1.00 60.70           C  \\nATOM      4  CB  MET A   1      39.461  16.796 -29.632  1.00 60.70           C  \\nATOM      5  O   MET A   1      36.269  16.755 -28.443  1.00 60.70           O  \\nATOM      6  CG  MET A   1      40.135  15.744 -30.527  1.00 60.70           C  \\nATOM      7  SD  MET A   1      41.521  14.854 -29.765  1.00 60.70           S  \\nATOM      8  CE  MET A   1      42.862  16.064 -29.883  1.00 60.70           C  \\nATOM      9  N   LEU A   2      37.301  18.742 -28.389  1.00 66.32           N  \\nATOM     10  CA  LEU A   2      36.431  19.268 -27.311  1.00 66.32           C  \\nATOM     11  C   LEU A   2      34.963  19.419 -27.754  1.00 66.32           C  \\nATOM     12  CB  LEU A   2      36.978  20.607 -26.772  1.00 66.32           C  \\nATOM     13  O   LEU A   2      34.069  19.025 -27.014  1.00 66.32           O  \\nATOM     14  CG  LEU A   2      38.201  20.479 -25.844  1.00 66.32           C  \\nATOM     15  CD1 LEU A   2      38.800  21.861 -25.582  1.00 66.32           C  \\nATOM     16  CD2 LEU A   2      37.846  19.854 -24.492  1.00 66.32           C  \\nATOM     17  N   ASP A   3      34.733  19.913 -28.976  1.00 78.24           N  \\nATOM     18  CA  ASP A   3      33.388  20.032 -29.565  1.00 78.24           C  \\nATOM     19  C   ASP A   3      32.722  18.652 -29.737  1.00 78.24           C  \\nATOM     20  CB  ASP A   3      33.514  20.801 -30.895  1.00 78.24           C  \\nATOM     21  O   ASP A   3      31.591  18.446 -29.312  1.00 78.24           O  \\nATOM     22  CG  ASP A   3      32.176  21.209 -31.531  1.00 78.24           C  \\nATOM     23  OD1 ASP A   3      31.128  21.192 -30.857  1.00 78.24           O  \\nATOM     24  OD2 ASP A   3      32.176  21.545 -32.735  1.00 78.24           O  \\nATOM     25  N   ASP A   4      33.462  17.654 -30.235  1.00 81.51           N  \\nATOM     26  CA  ASP A   4      32.934  16.293 -30.417  1.00 81.51           C  \\nATOM     27  C   ASP A   4      32.518  15.647 -29.089  1.00 81.51           C  \\nATOM     28  CB  ASP A   4      33.964  15.398 -31.121  1.00 81.51           C  \\nATOM     29  O   ASP A   4      31.462  15.023 -29.009  1.00 81.51           O  \\nATOM     30  CG  ASP A   4      34.515  16.040 -32.390  1.00 81.51           C  \\nATOM     31  OD1 ASP A   4      33.711  16.482 -33.231  1.00 81.51           O  \\nATOM     32  OD2 ASP A   4      35.761  16.218 -32.427  1.00 81.51           O  \\nATOM     33  N   ARG A   5      33.312  15.823 -28.023  1.00 79.75           N  \\nATOM     34  CA  ARG A   5      32.974  15.294 -26.694  1.00 79.75           C  \\nATOM     35  C   ARG A   5      31.726  15.960 -26.119  1.00 79.75           C  \\nATOM     36  CB  ARG A   5      34.178  15.412 -25.751  1.00 79.75           C  \\nATOM     37  O   ARG A   5      30.853  15.255 -25.625  1.00 79.75           O  \\nATOM     38  CG  ARG A   5      33.856  14.778 -24.392  1.00 79.75           C  \\nATOM     39  CD  ARG A   5      35.055  14.843 -23.452  1.00 79.75           C  \\nATOM     40  NE  ARG A   5      34.650  14.406 -22.113  1.00 79.75           N  \\nATOM     41  NH1 ARG A   5      36.721  14.355 -21.118  1.00 79.75           N  \\nATOM     42  NH2 ARG A   5      34.868  13.787 -19.975  1.00 79.75           N  \\nATOM     43  CZ  ARG A   5      35.425  14.182 -21.077  1.00 79.75           C  \\nATOM     44  N   ALA A   6      31.626  17.286 -26.219  1.00 82.64           N  \\nATOM     45  CA  ALA A   6      30.450  18.018 -25.756  1.00 82.64           C  \\nATOM     46  C   ALA A   6      29.185  17.595 -26.522  1.00 82.64           C  \\nATOM     47  CB  ALA A   6      30.727  19.518 -25.899  1.00 82.64           C  \\nATOM     48  O   ALA A   6      28.138  17.389 -25.913  1.00 82.64           O  \\nATOM     49  N   ARG A   7      29.291  17.387 -27.843  1.00 85.02           N  \\nATOM     50  CA  ARG A   7      28.191  16.868 -28.670  1.00 85.02           C  \\nATOM     51  C   ARG A   7      27.776  15.453 -28.266  1.00 85.02           C  \\nATOM     52  CB  ARG A   7      28.583  16.907 -30.151  1.00 85.02           C  \\nATOM     53  O   ARG A   7      26.583  15.187 -28.172  1.00 85.02           O  \\nATOM     54  CG  ARG A   7      28.633  18.335 -30.709  1.00 85.02           C  \\nATOM     55  CD  ARG A   7      29.134  18.280 -32.151  1.00 85.02           C  \\nATOM     56  NE  ARG A   7      29.458  19.619 -32.661  1.00 85.02           N  \\nATOM     57  NH1 ARG A   7      29.195  19.167 -34.898  1.00 85.02           N  \\nATOM     58  NH2 ARG A   7      29.938  21.162 -34.242  1.00 85.02           N  \\nATOM     59  CZ  ARG A   7      29.515  19.979 -33.927  1.00 85.02           C  \\nATOM     60  N   MET A   8      28.731  14.563 -27.991  1.00 84.70           N  \\nATOM     61  CA  MET A   8      28.434  13.203 -27.522  1.00 84.70           C  \\nATOM     62  C   MET A   8      27.769  13.195 -26.138  1.00 84.70           C  \\nATOM     63  CB  MET A   8      29.709  12.349 -27.495  1.00 84.70           C  \\nATOM     64  O   MET A   8      26.806  12.462 -25.934  1.00 84.70           O  \\nATOM     65  CG  MET A   8      30.181  11.952 -28.899  1.00 84.70           C  \\nATOM     66  SD  MET A   8      31.588  10.802 -28.930  1.00 84.70           S  \\nATOM     67  CE  MET A   8      32.896  11.823 -28.208  1.00 84.70           C  \\nATOM     68  N   GLU A   9      28.237  14.020 -25.196  1.00 85.54           N  \\nATOM     69  CA  GLU A   9      27.622  14.147 -23.865  1.00 85.54           C  \\nATOM     70  C   GLU A   9      26.205  14.746 -23.944  1.00 85.54           C  \\nATOM     71  CB  GLU A   9      28.535  14.970 -22.929  1.00 85.54           C  \\nATOM     72  O   GLU A   9      25.303  14.277 -23.248  1.00 85.54           O  \\nATOM     73  CG  GLU A   9      29.768  14.174 -22.443  1.00 85.54           C  \\nATOM     74  CD  GLU A   9      30.755  14.978 -21.563  1.00 85.54           C  \\nATOM     75  OE1 GLU A   9      31.864  14.443 -21.269  1.00 85.54           O  \\nATOM     76  OE2 GLU A   9      30.443  16.135 -21.210  1.00 85.54           O  \\nATOM     77  N   ALA A  10      25.976  15.720 -24.833  1.00 88.64           N  \\nATOM     78  CA  ALA A  10      24.648  16.280 -25.085  1.00 88.64           C  \\nATOM     79  C   ALA A  10      23.686  15.241 -25.686  1.00 88.64           C  \\nATOM     80  CB  ALA A  10      24.789  17.515 -25.982  1.00 88.64           C  \\nATOM     81  O   ALA A  10      22.583  15.072 -25.170  1.00 88.64           O  \\nATOM     82  N   ALA A  11      24.125  14.491 -26.703  1.00 91.48           N  \\nATOM     83  CA  ALA A  11      23.331  13.423 -27.315  1.00 91.48           C  \\nATOM     84  C   ALA A  11      23.015  12.292 -26.319  1.00 91.48           C  \\nATOM     85  CB  ALA A  11      24.099  12.894 -28.532  1.00 91.48           C  \\nATOM     86  O   ALA A  11      21.897  11.779 -26.285  1.00 91.48           O  \\nATOM     87  N   LYS A  12      23.980  11.934 -25.456  1.00 91.93           N  \\nATOM     88  CA  LYS A  12      23.772  10.989 -24.350  1.00 91.93           C  \\nATOM     89  C   LYS A  12      22.669  11.483 -23.412  1.00 91.93           C  \\nATOM     90  CB  LYS A  12      25.108  10.761 -23.614  1.00 91.93           C  \\nATOM     91  O   LYS A  12      21.759  10.724 -23.093  1.00 91.93           O  \\nATOM     92  CG  LYS A  12      24.963   9.814 -22.416  1.00 91.93           C  \\nATOM     93  CD  LYS A  12      26.284   9.567 -21.671  1.00 91.93           C  \\nATOM     94  CE  LYS A  12      25.910   8.628 -20.526  1.00 91.93           C  \\nATOM     95  NZ  LYS A  12      27.026   8.112 -19.694  1.00 91.93           N  \\nATOM     96  N   LYS A  13      22.736  12.747 -22.984  1.00 92.69           N  \\nATOM     97  CA  LYS A  13      21.739  13.346 -22.086  1.00 92.69           C  \\nATOM     98  C   LYS A  13      20.345  13.381 -22.715  1.00 92.69           C  \\nATOM     99  CB  LYS A  13      22.216  14.743 -21.667  1.00 92.69           C  \\nATOM    100  O   LYS A  13      19.381  13.041 -22.043  1.00 92.69           O  \\nATOM    101  CG  LYS A  13      21.267  15.361 -20.633  1.00 92.69           C  \\nATOM    102  CD  LYS A  13      21.762  16.734 -20.177  1.00 92.69           C  \\nATOM    103  CE  LYS A  13      20.733  17.298 -19.195  1.00 92.69           C  \\nATOM    104  NZ  LYS A  13      21.122  18.638 -18.700  1.00 92.69           N  \\nATOM    105  N   GLU A  14      20.245  13.753 -23.988  1.00 94.75           N  \\nATOM    106  CA  GLU A  14      18.976  13.773 -24.724  1.00 94.75           C  \\nATOM    107  C   GLU A  14      18.333  12.382 -24.778  1.00 94.75           C  \\nATOM    108  CB  GLU A  14      19.245  14.333 -26.127  1.00 94.75           C  \\nATOM    109  O   GLU A  14      17.157  12.237 -24.454  1.00 94.75           O  \\nATOM    110  CG  GLU A  14      17.969  14.520 -26.962  1.00 94.75           C  \\nATOM    111  CD  GLU A  14      18.247  15.162 -28.333  1.00 94.75           C  \\nATOM    112  OE1 GLU A  14      17.259  15.447 -29.045  1.00 94.75           O  \\nATOM    113  OE2 GLU A  14      19.436  15.386 -28.664  1.00 94.75           O  \\nATOM    114  N   LYS A  15      19.119  11.342 -25.083  1.00 96.79           N  \\nATOM    115  CA  LYS A  15      18.615   9.965 -25.139  1.00 96.79           C  \\nATOM    116  C   LYS A  15      18.205   9.422 -23.764  1.00 96.79           C  \\nATOM    117  CB  LYS A  15      19.659   9.083 -25.833  1.00 96.79           C  \\nATOM    118  O   LYS A  15      17.219   8.698 -23.669  1.00 96.79           O  \\nATOM    119  CG  LYS A  15      19.039   7.759 -26.297  1.00 96.79           C  \\nATOM    120  CD  LYS A  15      20.049   6.938 -27.107  1.00 96.79           C  \\nATOM    121  CE  LYS A  15      19.474   5.553 -27.397  1.00 96.79           C  \\nATOM    122  NZ  LYS A  15      20.485   4.644 -27.983  1.00 96.79           N  \\nATOM    123  N   VAL A  16      18.922   9.792 -22.698  1.00 97.86           N  \\nATOM    124  CA  VAL A  16      18.512   9.475 -21.318  1.00 97.86           C  \\nATOM    125  C   VAL A  16      17.164  10.119 -21.001  1.00 97.86           C  \\nATOM    126  CB  VAL A  16      19.572   9.912 -20.288  1.00 97.86           C  \\nATOM    127  O   VAL A  16      16.260   9.426 -20.548  1.00 97.86           O  \\nATOM    128  CG1 VAL A  16      19.068   9.804 -18.842  1.00 97.86           C  \\nATOM    129  CG2 VAL A  16      20.837   9.051 -20.388  1.00 97.86           C  \\nATOM    130  N   GLU A  17      16.999  11.419 -21.260  1.00 97.61           N  \\nATOM    131  CA  GLU A  17      15.728  12.103 -20.983  1.00 97.61           C  \\nATOM    132  C   GLU A  17      14.587  11.564 -21.858  1.00 97.61           C  \\nATOM    133  CB  GLU A  17      15.868  13.625 -21.141  1.00 97.61           C  \\nATOM    134  O   GLU A  17      13.459  11.505 -21.386  1.00 97.61           O  \\nATOM    135  CG  GLU A  17      16.793  14.298 -20.104  1.00 97.61           C  \\nATOM    136  CD  GLU A  17      16.328  14.240 -18.629  1.00 97.61           C  \\nATOM    137  OE1 GLU A  17      17.206  14.199 -17.734  1.00 97.61           O  \\nATOM    138  OE2 GLU A  17      15.119  14.354 -18.324  1.00 97.61           O  \\nATOM    139  N   GLN A  18      14.861  11.099 -23.082  1.00 97.55           N  \\nATOM    140  CA  GLN A  18      13.860  10.435 -23.920  1.00 97.55           C  \\nATOM    141  C   GLN A  18      13.335   9.136 -23.288  1.00 97.55           C  \\nATOM    142  CB  GLN A  18      14.450  10.176 -25.315  1.00 97.55           C  \\nATOM    143  O   GLN A  18      12.127   8.924 -23.278  1.00 97.55           O  \\nATOM    144  CG  GLN A  18      13.397   9.607 -26.278  1.00 97.55           C  \\nATOM    145  CD  GLN A  18      13.946   9.282 -27.662  1.00 97.55           C  \\nATOM    146  NE2 GLN A  18      13.108   8.791 -28.548  1.00 97.55           N  \\nATOM    147  OE1 GLN A  18      15.115   9.435 -27.983  1.00 97.55           O  \\nATOM    148  N   ILE A  19      14.217   8.287 -22.745  1.00 98.10           N  \\nATOM    149  CA  ILE A  19      13.818   7.049 -22.050  1.00 98.10           C  \\nATOM    150  C   ILE A  19      13.058   7.390 -20.762  1.00 98.10           C  \\nATOM    151  CB  ILE A  19      15.062   6.167 -21.773  1.00 98.10           C  \\nATOM    152  O   ILE A  19      11.996   6.847 -20.481  1.00 98.10           O  \\nATOM    153  CG1 ILE A  19      15.640   5.633 -23.105  1.00 98.10           C  \\nATOM    154  CG2 ILE A  19      14.723   4.992 -20.835  1.00 98.10           C  \\nATOM    155  CD1 ILE A  19      17.038   5.015 -22.978  1.00 98.10           C  \\nATOM    156  N   LEU A  20      13.567   8.337 -19.974  1.00 98.38           N  \\nATOM    157  CA  LEU A  20      12.933   8.711 -18.708  1.00 98.38           C  \\nATOM    158  C   LEU A  20      11.607   9.469 -18.895  1.00 98.38           C  \\nATOM    159  CB  LEU A  20      13.935   9.504 -17.858  1.00 98.38           C  \\nATOM    160  O   LEU A  20      10.766   9.454 -17.995  1.00 98.38           O  \\nATOM    161  CG  LEU A  20      15.193   8.714 -17.441  1.00 98.38           C  \\nATOM    162  CD1 LEU A  20      16.049   9.599 -16.539  1.00 98.38           C  \\nATOM    163  CD2 LEU A  20      14.874   7.425 -16.684  1.00 98.38           C  \\nATOM    164  N   ALA A  21      11.383  10.096 -20.054  1.00 97.79           N  \\nATOM    165  CA  ALA A  21      10.121  10.750 -20.391  1.00 97.79           C  \\nATOM    166  C   ALA A  21       8.939   9.770 -20.467  1.00 97.79           C  \\nATOM    167  CB  ALA A  21      10.278  11.535 -21.698  1.00 97.79           C  \\nATOM    168  O   ALA A  21       7.809  10.195 -20.246  1.00 97.79           O  \\nATOM    169  N   GLU A  22       9.175   8.470 -20.686  1.00 97.70           N  \\nATOM    170  CA  GLU A  22       8.130   7.432 -20.664  1.00 97.70           C  \\nATOM    171  C   GLU A  22       7.412   7.350 -19.305  1.00 97.70           C  \\nATOM    172  CB  GLU A  22       8.753   6.063 -20.988  1.00 97.70           C  \\nATOM    173  O   GLU A  22       6.244   6.979 -19.228  1.00 97.70           O  \\nATOM    174  CG  GLU A  22       9.398   6.003 -22.382  1.00 97.70           C  \\nATOM    175  CD  GLU A  22      10.020   4.629 -22.687  1.00 97.70           C  \\nATOM    176  OE1 GLU A  22       9.765   4.133 -23.809  1.00 97.70           O  \\nATOM    177  OE2 GLU A  22      10.766   4.094 -21.830  1.00 97.70           O  \\nATOM    178  N   PHE A  23       8.089   7.739 -18.220  1.00 98.41           N  \\nATOM    179  CA  PHE A  23       7.521   7.754 -16.871  1.00 98.41           C  \\nATOM    180  C   PHE A  23       6.689   9.009 -16.572  1.00 98.41           C  \\nATOM    181  CB  PHE A  23       8.659   7.600 -15.852  1.00 98.41           C  \\nATOM    182  O   PHE A  23       6.019   9.075 -15.537  1.00 98.41           O  \\nATOM    183  CG  PHE A  23       9.287   6.222 -15.844  1.00 98.41           C  \\nATOM    184  CD1 PHE A  23       8.852   5.269 -14.906  1.00 98.41           C  \\nATOM    185  CD2 PHE A  23      10.265   5.873 -16.795  1.00 98.41           C  \\nATOM    186  CE1 PHE A  23       9.353   3.958 -14.946  1.00 98.41           C  \\nATOM    187  CE2 PHE A  23      10.782   4.568 -16.821  1.00 98.41           C  \\nATOM    188  CZ  PHE A  23      10.315   3.610 -15.905  1.00 98.41           C  \\nATOM    189  N   GLN A  24       6.742  10.029 -17.433  1.00 97.81           N  \\nATOM    190  CA  GLN A  24       6.075  11.305 -17.196  1.00 97.81           C  \\nATOM    191  C   GLN A  24       4.607  11.238 -17.615  1.00 97.81           C  \\nATOM    192  CB  GLN A  24       6.800  12.450 -17.915  1.00 97.81           C  \\nATOM    193  O   GLN A  24       4.276  11.236 -18.796  1.00 97.81           O  \\nATOM    194  CG  GLN A  24       8.225  12.661 -17.389  1.00 97.81           C  \\nATOM    195  CD  GLN A  24       8.949  13.804 -18.094  1.00 97.81           C  \\nATOM    196  NE2 GLN A  24      10.250  13.903 -17.927  1.00 97.81           N  \\nATOM    197  OE1 GLN A  24       8.385  14.634 -18.787  1.00 97.81           O  \\nATOM    198  N   LEU A  25       3.719  11.260 -16.624  1.00 97.99           N  \\nATOM    199  CA  LEU A  25       2.274  11.340 -16.833  1.00 97.99           C  \\nATOM    200  C   LEU A  25       1.817  12.801 -16.866  1.00 97.99           C  \\nATOM    201  CB  LEU A  25       1.557  10.545 -15.730  1.00 97.99           C  \\nATOM    202  O   LEU A  25       2.172  13.582 -15.976  1.00 97.99           O  \\nATOM    203  CG  LEU A  25       1.915   9.047 -15.707  1.00 97.99           C  \\nATOM    204  CD1 LEU A  25       1.310   8.402 -14.463  1.00 97.99           C  \\nATOM    205  CD2 LEU A  25       1.400   8.308 -16.942  1.00 97.99           C  \\nATOM    206  N   GLN A  26       1.007  13.160 -17.861  1.00 97.23           N  \\nATOM    207  CA  GLN A  26       0.364  14.472 -17.935  1.00 97.23           C  \\nATOM    208  C   GLN A  26      -0.884  14.515 -17.047  1.00 97.23           C  \\nATOM    209  CB  GLN A  26       0.018  14.820 -19.393  1.00 97.23           C  \\nATOM    210  O   GLN A  26      -1.458  13.488 -16.691  1.00 97.23           O  \\nATOM    211  CG  GLN A  26       1.233  14.789 -20.334  1.00 97.23           C  \\nATOM    212  CD  GLN A  26       2.348  15.730 -19.889  1.00 97.23           C  \\nATOM    213  NE2 GLN A  26       3.576  15.264 -19.824  1.00 97.23           N  \\nATOM    214  OE1 GLN A  26       2.130  16.894 -19.582  1.00 97.23           O  \\nATOM    215  N   GLU A  27      -1.367  15.714 -16.716  1.00 97.87           N  \\nATOM    216  CA  GLU A  27      -2.582  15.857 -15.900  1.00 97.87           C  \\nATOM    217  C   GLU A  27      -3.803  15.163 -16.533  1.00 97.87           C  \\nATOM    218  CB  GLU A  27      -2.862  17.348 -15.667  1.00 97.87           C  \\nATOM    219  O   GLU A  27      -4.608  14.557 -15.828  1.00 97.87           O  \\nATOM    220  CG  GLU A  27      -3.965  17.557 -14.622  1.00 97.87           C  \\nATOM    221  CD  GLU A  27      -4.282  19.041 -14.430  1.00 97.87           C  \\nATOM    222  OE1 GLU A  27      -5.455  19.410 -14.694  1.00 97.87           O  \\nATOM    223  OE2 GLU A  27      -3.356  19.780 -14.028  1.00 97.87           O  \\nATOM    224  N   GLU A  28      -3.923  15.188 -17.863  1.00 98.21           N  \\nATOM    225  CA  GLU A  28      -4.998  14.483 -18.570  1.00 98.21           C  \\nATOM    226  C   GLU A  28      -4.882  12.956 -18.468  1.00 98.21           C  \\nATOM    227  CB  GLU A  28      -5.060  14.935 -20.039  1.00 98.21           C  \\nATOM    228  O   GLU A  28      -5.907  12.277 -18.381  1.00 98.21           O  \\nATOM    229  CG  GLU A  28      -5.570  16.379 -20.201  1.00 98.21           C  \\nATOM    230  CD  GLU A  28      -6.943  16.611 -19.536  1.00 98.21           C  \\nATOM    231  OE1 GLU A  28      -7.112  17.646 -18.842  1.00 98.21           O  \\nATOM    232  OE2 GLU A  28      -7.826  15.725 -19.637  1.00 98.21           O  \\nATOM    233  N   ASP A  29      -3.665  12.410 -18.392  1.00 98.50           N  \\nATOM    234  CA  ASP A  29      -3.448  10.982 -18.139  1.00 98.50           C  \\nATOM    235  C   ASP A  29      -3.942  10.614 -16.738  1.00 98.50           C  \\nATOM    236  CB  ASP A  29      -1.964  10.623 -18.308  1.00 98.50           C  \\nATOM    237  O   ASP A  29      -4.709   9.666 -16.567  1.00 98.50           O  \\nATOM    238  CG  ASP A  29      -1.460  10.921 -19.721  1.00 98.50           C  \\nATOM    239  OD1 ASP A  29      -2.213  10.628 -20.684  1.00 98.50           O  \\nATOM    240  OD2 ASP A  29      -0.351  11.498 -19.804  1.00 98.50           O  \\nATOM    241  N   LEU A  30      -3.613  11.438 -15.741  1.00 98.74           N  \\nATOM    242  CA  LEU A  30      -4.077  11.241 -14.367  1.00 98.74           C  \\nATOM    243  C   LEU A  30      -5.600  11.355 -14.247  1.00 98.74           C  \\nATOM    244  CB  LEU A  30      -3.368  12.228 -13.427  1.00 98.74           C  \\nATOM    245  O   LEU A  30      -6.217  10.562 -13.538  1.00 98.74           O  \\nATOM    246  CG  LEU A  30      -1.833  12.144 -13.448  1.00 98.74           C  \\nATOM    247  CD1 LEU A  30      -1.252  13.129 -12.434  1.00 98.74           C  \\nATOM    248  CD2 LEU A  30      -1.317  10.739 -13.139  1.00 98.74           C  \\nATOM    249  N   LYS A  31      -6.238  12.269 -14.988  1.00 98.66           N  \\nATOM    250  CA  LYS A  31      -7.707  12.352 -15.057  1.00 98.66           C  \\nATOM    251  C   LYS A  31      -8.329  11.112 -15.701  1.00 98.66           C  \\nATOM    252  CB  LYS A  31      -8.140  13.608 -15.819  1.00 98.66           C  \\nATOM    253  O   LYS A  31      -9.411  10.706 -15.280  1.00 98.66           O  \\nATOM    254  CG  LYS A  31      -7.930  14.895 -15.012  1.00 98.66           C  \\nATOM    255  CD  LYS A  31      -8.233  16.108 -15.898  1.00 98.66           C  \\nATOM    256  CE  LYS A  31      -7.854  17.401 -15.178  1.00 98.66           C  \\nATOM    257  NZ  LYS A  31      -7.629  18.508 -16.136  1.00 98.66           N  \\nATOM    258  N   LYS A  32      -7.693  10.495 -16.705  1.00 98.62           N  \\nATOM    259  CA  LYS A  32      -8.167   9.215 -17.268  1.00 98.62           C  \\nATOM    260  C   LYS A  32      -8.091   8.099 -16.226  1.00 98.62           C  \\nATOM    261  CB  LYS A  32      -7.346   8.796 -18.490  1.00 98.62           C  \\nATOM    262  O   LYS A  32      -9.092   7.412 -16.031  1.00 98.62           O  \\nATOM    263  CG  LYS A  32      -7.537   9.617 -19.775  1.00 98.62           C  \\nATOM    264  CD  LYS A  32      -6.441   9.123 -20.728  1.00 98.62           C  \\nATOM    265  CE  LYS A  32      -6.374   9.750 -22.114  1.00 98.62           C  \\nATOM    266  NZ  LYS A  32      -5.176   9.188 -22.800  1.00 98.62           N  \\nATOM    267  N   VAL A  33      -6.949   7.954 -15.549  1.00 98.75           N  \\nATOM    268  CA  VAL A  33      -6.742   6.968 -14.470  1.00 98.75           C  \\nATOM    269  C   VAL A  33      -7.793   7.156 -13.373  1.00 98.75           C  \\nATOM    270  CB  VAL A  33      -5.309   7.083 -13.904  1.00 98.75           C  \\nATOM    271  O   VAL A  33      -8.487   6.207 -13.024  1.00 98.75           O  \\nATOM    272  CG1 VAL A  33      -5.048   6.190 -12.687  1.00 98.75           C  \\nATOM    273  CG2 VAL A  33      -4.269   6.678 -14.956  1.00 98.75           C  \\nATOM    274  N   MET A  34      -7.991   8.394 -12.913  1.00 98.59           N  \\nATOM    275  CA  MET A  34      -8.990   8.764 -11.907  1.00 98.59           C  \\nATOM    276  C   MET A  34     -10.418   8.364 -12.312  1.00 98.59           C  \\nATOM    277  CB  MET A  34      -8.888  10.279 -11.692  1.00 98.59           C  \\nATOM    278  O   MET A  34     -11.116   7.709 -11.542  1.00 98.59           O  \\nATOM    279  CG  MET A  34      -9.846  10.811 -10.629  1.00 98.59           C  \\nATOM    280  SD  MET A  34      -9.858  12.617 -10.534  1.00 98.59           S  \\nATOM    281  CE  MET A  34     -10.885  13.004 -11.976  1.00 98.59           C  \\nATOM    282  N   ARG A  35     -10.856   8.705 -13.533  1.00 98.46           N  \\nATOM    283  CA  ARG A  35     -12.208   8.361 -14.017  1.00 98.46           C  \\nATOM    284  C   ARG A  35     -12.406   6.852 -14.168  1.00 98.46           C  \\nATOM    285  CB  ARG A  35     -12.486   9.042 -15.362  1.00 98.46           C  \\nATOM    286  O   ARG A  35     -13.491   6.345 -13.897  1.00 98.46           O  \\nATOM    287  CG  ARG A  35     -12.665  10.564 -15.263  1.00 98.46           C  \\nATOM    288  CD  ARG A  35     -12.835  11.130 -16.681  1.00 98.46           C  \\nATOM    289  NE  ARG A  35     -12.507  12.569 -16.761  1.00 98.46           N  \\nATOM    290  NH1 ARG A  35     -11.067  12.494 -18.566  1.00 98.46           N  \\nATOM    291  NH2 ARG A  35     -11.467  14.434 -17.582  1.00 98.46           N  \\nATOM    292  CZ  ARG A  35     -11.692  13.152 -17.631  1.00 98.46           C  \\nATOM    293  N   ARG A  36     -11.376   6.126 -14.617  1.00 98.48           N  \\nATOM    294  CA  ARG A  36     -11.418   4.658 -14.715  1.00 98.48           C  \\nATOM    295  C   ARG A  36     -11.486   4.009 -13.337  1.00 98.48           C  \\nATOM    296  CB  ARG A  36     -10.213   4.133 -15.496  1.00 98.48           C  \\nATOM    297  O   ARG A  36     -12.287   3.100 -13.166  1.00 98.48           O  \\nATOM    298  CG  ARG A  36     -10.339   4.398 -16.994  1.00 98.48           C  \\nATOM    299  CD  ARG A  36      -9.145   3.772 -17.711  1.00 98.48           C  \\nATOM    300  NE  ARG A  36      -9.166   4.112 -19.139  1.00 98.48           N  \\nATOM    301  NH1 ARG A  36      -6.947   3.707 -19.570  1.00 98.48           N  \\nATOM    302  NH2 ARG A  36      -8.190   4.754 -21.070  1.00 98.48           N  \\nATOM    303  CZ  ARG A  36      -8.107   4.169 -19.915  1.00 98.48           C  \\nATOM    304  N   MET A  37     -10.737   4.529 -12.364  1.00 98.54           N  \\nATOM    305  CA  MET A  37     -10.836   4.106 -10.967  1.00 98.54           C  \\nATOM    306  C   MET A  37     -12.268   4.283 -10.446  1.00 98.54           C  \\nATOM    307  CB  MET A  37      -9.819   4.884 -10.114  1.00 98.54           C  \\nATOM    308  O   MET A  37     -12.851   3.321  -9.966  1.00 98.54           O  \\nATOM    309  CG  MET A  37      -9.827   4.452  -8.643  1.00 98.54           C  \\nATOM    310  SD  MET A  37      -9.274   2.755  -8.341  1.00 98.54           S  \\nATOM    311  CE  MET A  37      -7.488   2.936  -8.582  1.00 98.54           C  \\nATOM    312  N   GLN A  38     -12.880   5.464 -10.616  1.00 98.33           N  \\nATOM    313  CA  GLN A  38     -14.271   5.705 -10.189  1.00 98.33           C  \\nATOM    314  C   GLN A  38     -15.258   4.718 -10.827  1.00 98.33           C  \\nATOM    315  CB  GLN A  38     -14.700   7.139 -10.536  1.00 98.33           C  \\nATOM    316  O   GLN A  38     -16.119   4.178 -10.136  1.00 98.33           O  \\nATOM    317  CG  GLN A  38     -14.044   8.196  -9.640  1.00 98.33           C  \\nATOM    318  CD  GLN A  38     -14.454   9.607 -10.059  1.00 98.33           C  \\nATOM    319  NE2 GLN A  38     -15.281  10.282  -9.287  1.00 98.33           N  \\nATOM    320  OE1 GLN A  38     -14.039  10.098 -11.103  1.00 98.33           O  \\nATOM    321  N   LYS A  39     -15.099   4.435 -12.126  1.00 98.26           N  \\nATOM    322  CA  LYS A  39     -15.931   3.455 -12.832  1.00 98.26           C  \\nATOM    323  C   LYS A  39     -15.781   2.044 -12.251  1.00 98.26           C  \\nATOM    324  CB  LYS A  39     -15.588   3.488 -14.326  1.00 98.26           C  \\nATOM    325  O   LYS A  39     -16.784   1.358 -12.082  1.00 98.26           O  \\nATOM    326  CG  LYS A  39     -16.510   2.563 -15.129  1.00 98.26           C  \\nATOM    327  CD  LYS A  39     -16.054   2.460 -16.584  1.00 98.26           C  \\nATOM    328  CE  LYS A  39     -16.928   1.410 -17.273  1.00 98.26           C  \\nATOM    329  NZ  LYS A  39     -16.346   0.981 -18.564  1.00 98.26           N  \\nATOM    330  N   GLU A  40     -14.561   1.602 -11.957  1.00 98.47           N  \\nATOM    331  CA  GLU A  40     -14.345   0.280 -11.356  1.00 98.47           C  \\nATOM    332  C   GLU A  40     -14.818   0.221  -9.900  1.00 98.47           C  \\nATOM    333  CB  GLU A  40     -12.879  -0.159 -11.496  1.00 98.47           C  \\nATOM    334  O   GLU A  40     -15.348  -0.803  -9.485  1.00 98.47           O  \\nATOM    335  CG  GLU A  40     -12.487  -0.500 -12.944  1.00 98.47           C  \\nATOM    336  CD  GLU A  40     -13.431  -1.540 -13.573  1.00 98.47           C  \\nATOM    337  OE1 GLU A  40     -14.058  -1.223 -14.620  1.00 98.47           O  \\nATOM    338  OE2 GLU A  40     -13.704  -2.589 -12.945  1.00 98.47           O  \\nATOM    339  N   MET A  41     -14.747   1.325  -9.150  1.00 98.52           N  \\nATOM    340  CA  MET A  41     -15.372   1.426  -7.826  1.00 98.52           C  \\nATOM    341  C   MET A  41     -16.901   1.289  -7.907  1.00 98.52           C  \\nATOM    342  CB  MET A  41     -15.023   2.765  -7.165  1.00 98.52           C  \\nATOM    343  O   MET A  41     -17.491   0.554  -7.120  1.00 98.52           O  \\nATOM    344  CG  MET A  41     -13.541   2.937  -6.815  1.00 98.52           C  \\nATOM    345  SD  MET A  41     -13.135   4.622  -6.272  1.00 98.52           S  \\nATOM    346  CE  MET A  41     -13.899   4.565  -4.629  1.00 98.52           C  \\nATOM    347  N   ASP A  42     -17.551   1.949  -8.874  1.00 97.88           N  \\nATOM    348  CA  ASP A  42     -18.991   1.778  -9.120  1.00 97.88           C  \\nATOM    349  C   ASP A  42     -19.338   0.327  -9.445  1.00 97.88           C  \\nATOM    350  CB  ASP A  42     -19.461   2.650 -10.299  1.00 97.88           C  \\nATOM    351  O   ASP A  42     -20.325  -0.204  -8.938  1.00 97.88           O  \\nATOM    352  CG  ASP A  42     -19.789   4.081  -9.908  1.00 97.88           C  \\nATOM    353  OD1 ASP A  42     -20.393   4.257  -8.825  1.00 97.88           O  \\nATOM    354  OD2 ASP A  42     -19.489   4.993 -10.704  1.00 97.88           O  \\nATOM    355  N   ARG A  43     -18.524  -0.329 -10.281  1.00 98.22           N  \\nATOM    356  CA  ARG A  43     -18.731  -1.739 -10.617  1.00 98.22           C  \\nATOM    357  C   ARG A  43     -18.532  -2.648  -9.408  1.00 98.22           C  \\nATOM    358  CB  ARG A  43     -17.810  -2.179 -11.759  1.00 98.22           C  \\nATOM    359  O   ARG A  43     -19.302  -3.589  -9.242  1.00 98.22           O  \\nATOM    360  CG  ARG A  43     -18.212  -1.578 -13.109  1.00 98.22           C  \\nATOM    361  CD  ARG A  43     -17.203  -2.002 -14.180  1.00 98.22           C  \\nATOM    362  NE  ARG A  43     -17.327  -3.429 -14.549  1.00 98.22           N  \\nATOM    363  NH1 ARG A  43     -15.137  -3.775 -15.187  1.00 98.22           N  \\nATOM    364  NH2 ARG A  43     -16.578  -5.461 -15.274  1.00 98.22           N  \\nATOM    365  CZ  ARG A  43     -16.350  -4.207 -14.993  1.00 98.22           C  \\nATOM    366  N   GLY A  44     -17.534  -2.360  -8.576  1.00 97.95           N  \\nATOM    367  CA  GLY A  44     -17.220  -3.124  -7.373  1.00 97.95           C  \\nATOM    368  C   GLY A  44     -18.308  -3.056  -6.309  1.00 97.95           C  \\nATOM    369  O   GLY A  44     -18.507  -4.024  -5.587  1.00 97.95           O  \\nATOM    370  N   LEU A  45     -19.032  -1.943  -6.218  1.00 97.67           N  \\nATOM    371  CA  LEU A  45     -20.094  -1.757  -5.226  1.00 97.67           C  \\nATOM    372  C   LEU A  45     -21.442  -2.378  -5.617  1.00 97.67           C  \\nATOM    373  CB  LEU A  45     -20.238  -0.252  -4.981  1.00 97.67           C  \\nATOM    374  O   LEU A  45     -22.279  -2.606  -4.743  1.00 97.67           O  \\nATOM    375  CG  LEU A  45     -19.154   0.318  -4.056  1.00 97.67           C  \\nATOM    376  CD1 LEU A  45     -19.211   1.836  -4.100  1.00 97.67           C  \\nATOM    377  CD2 LEU A  45     -19.334  -0.116  -2.603  1.00 97.67           C  \\nATOM    378  N   ARG A  46     -21.659  -2.647  -6.909  1.00 97.47           N  \\nATOM    379  CA  ARG A  46     -22.913  -3.205  -7.432  1.00 97.47           C  \\nATOM    380  C   ARG A  46     -22.898  -4.721  -7.450  1.00 97.47           C  \\nATOM    381  CB  ARG A  46     -23.181  -2.692  -8.842  1.00 97.47           C  \\nATOM    382  O   ARG A  46     -21.939  -5.324  -7.931  1.00 97.47           O  \\nATOM    383  CG  ARG A  46     -23.542  -1.211  -8.853  1.00 97.47           C  \\nATOM    384  CD  ARG A  46     -23.707  -0.786 -10.308  1.00 97.47           C  \\nATOM    385  NE  ARG A  46     -23.852   0.671 -10.405  1.00 97.47           N  \\nATOM    386  NH1 ARG A  46     -24.542   0.732 -12.582  1.00 97.47           N  \\nATOM    387  NH2 ARG A  46     -24.261   2.643 -11.441  1.00 97.47           N  \\nATOM    388  CZ  ARG A  46     -24.219   1.341 -11.473  1.00 97.47           C  \\nATOM    389  N   LEU A  47     -24.004  -5.335  -7.041  1.00 95.11           N  \\nATOM    390  CA  LEU A  47     -24.113  -6.792  -6.948  1.00 95.11           C  \\nATOM    391  C   LEU A  47     -23.919  -7.473  -8.314  1.00 95.11           C  \\nATOM    392  CB  LEU A  47     -25.477  -7.133  -6.323  1.00 95.11           C  \\nATOM    393  O   LEU A  47     -23.271  -8.511  -8.398  1.00 95.11           O  \\nATOM    394  CG  LEU A  47     -25.678  -8.632  -6.030  1.00 95.11           C  \\nATOM    395  CD1 LEU A  47     -24.730  -9.136  -4.939  1.00 95.11           C  \\nATOM    396  CD2 LEU A  47     -27.114  -8.878  -5.568  1.00 95.11           C  \\nATOM    397  N   GLU A  48     -24.441  -6.867  -9.384  1.00 97.04           N  \\nATOM    398  CA  GLU A  48     -24.373  -7.405 -10.752  1.00 97.04           C  \\nATOM    399  C   GLU A  48     -22.946  -7.429 -11.321  1.00 97.04           C  \\nATOM    400  CB  GLU A  48     -25.305  -6.569 -11.650  1.00 97.04           C  \\nATOM    401  O   GLU A  48     -22.599  -8.331 -12.077  1.00 97.04           O  \\nATOM    402  CG  GLU A  48     -25.420  -7.100 -13.092  1.00 97.04           C  \\nATOM    403  CD  GLU A  48     -26.362  -6.275 -13.990  1.00 97.04           C  \\nATOM    404  OE1 GLU A  48     -26.570  -6.693 -15.153  1.00 97.04           O  \\nATOM    405  OE2 GLU A  48     -26.867  -5.220 -13.540  1.00 97.04           O  \\nATOM    406  N   THR A  49     -22.109  -6.448 -10.972  1.00 97.71           N  \\nATOM    407  CA  THR A  49     -20.794  -6.249 -11.607  1.00 97.71           C  \\nATOM    408  C   THR A  49     -19.604  -6.516 -10.687  1.00 97.71           C  \\nATOM    409  CB  THR A  49     -20.689  -4.852 -12.230  1.00 97.71           C  \\nATOM    410  O   THR A  49     -18.470  -6.523 -11.163  1.00 97.71           O  \\nATOM    411  CG2 THR A  49     -21.639  -4.666 -13.412  1.00 97.71           C  \\nATOM    412  OG1 THR A  49     -21.030  -3.848 -11.310  1.00 97.71           O  \\nATOM    413  N   HIS A  50     -19.834  -6.760  -9.395  1.00 96.77           N  \\nATOM    414  CA  HIS A  50     -18.790  -6.948  -8.383  1.00 96.77           C  \\nATOM    415  C   HIS A  50     -17.804  -8.080  -8.711  1.00 96.77           C  \\nATOM    416  CB  HIS A  50     -19.489  -7.231  -7.048  1.00 96.77           C  \\nATOM    417  O   HIS A  50     -16.589  -7.945  -8.523  1.00 96.77           O  \\nATOM    418  CG  HIS A  50     -18.541  -7.581  -5.935  1.00 96.77           C  \\nATOM    419  CD2 HIS A  50     -18.244  -8.828  -5.458  1.00 96.77           C  \\nATOM    420  ND1 HIS A  50     -17.826  -6.686  -5.187  1.00 96.77           N  \\nATOM    421  CE1 HIS A  50     -17.138  -7.368  -4.265  1.00 96.77           C  \\nATOM    422  NE2 HIS A  50     -17.340  -8.688  -4.398  1.00 96.77           N  \\nATOM    423  N   GLU A  51     -18.307  -9.207  -9.223  1.00 94.57           N  \\nATOM    424  CA  GLU A  51     -17.473 -10.370  -9.552  1.00 94.57           C  \\nATOM    425  C   GLU A  51     -16.443 -10.045 -10.647  1.00 94.57           C  \\nATOM    426  CB  GLU A  51     -18.371 -11.554  -9.946  1.00 94.57           C  \\nATOM    427  O   GLU A  51     -15.287 -10.459 -10.548  1.00 94.57           O  \\nATOM    428  CG  GLU A  51     -17.556 -12.851 -10.095  1.00 94.57           C  \\nATOM    429  CD  GLU A  51     -18.408 -14.102 -10.372  1.00 94.57           C  \\nATOM    430  OE1 GLU A  51     -17.795 -15.188 -10.498  1.00 94.57           O  \\nATOM    431  OE2 GLU A  51     -19.653 -13.991 -10.425  1.00 94.57           O  \\nATOM    432  N   GLU A  52     -16.818  -9.218 -11.623  1.00 95.46           N  \\nATOM    433  CA  GLU A  52     -15.971  -8.824 -12.755  1.00 95.46           C  \\nATOM    434  C   GLU A  52     -15.170  -7.536 -12.519  1.00 95.46           C  \\nATOM    435  CB  GLU A  52     -16.848  -8.600 -13.988  1.00 95.46           C  \\nATOM    436  O   GLU A  52     -14.249  -7.243 -13.279  1.00 95.46           O  \\nATOM    437  CG  GLU A  52     -17.655  -9.819 -14.453  1.00 95.46           C  \\nATOM    438  CD  GLU A  52     -18.460  -9.496 -15.724  1.00 95.46           C  \\nATOM    439  OE1 GLU A  52     -18.987 -10.453 -16.335  1.00 95.46           O  \\nATOM    440  OE2 GLU A  52     -18.514  -8.296 -16.104  1.00 95.46           O  \\nATOM    441  N   ALA A  53     -15.531  -6.733 -11.515  1.00 97.22           N  \\nATOM    442  CA  ALA A  53     -14.846  -5.479 -11.217  1.00 97.22           C  \\nATOM    443  C   ALA A  53     -13.401  -5.738 -10.774  1.00 97.22           C  \\nATOM    444  CB  ALA A  53     -15.625  -4.731 -10.133  1.00 97.22           C  \\nATOM    445  O   ALA A  53     -13.153  -6.631  -9.953  1.00 97.22           O  \\nATOM    446  N   SER A  54     -12.449  -4.941 -11.263  1.00 96.53           N  \\nATOM    447  CA  SER A  54     -11.054  -5.056 -10.819  1.00 96.53           C  \\nATOM    448  C   SER A  54     -10.874  -4.500  -9.400  1.00 96.53           C  \\nATOM    449  CB  SER A  54     -10.129  -4.356 -11.821  1.00 96.53           C  \\nATOM    450  O   SER A  54     -10.081  -5.009  -8.616  1.00 96.53           O  \\nATOM    451  OG  SER A  54     -10.189  -2.952 -11.659  1.00 96.53           O  \\nATOM    452  N   VAL A  55     -11.630  -3.453  -9.055  1.00 97.96           N  \\nATOM    453  CA  VAL A  55     -11.655  -2.837  -7.722  1.00 97.96           C  \\nATOM    454  C   VAL A  55     -12.819  -3.444  -6.946  1.00 97.96           C  \\nATOM    455  CB  VAL A  55     -11.779  -1.305  -7.827  1.00 97.96           C  \\nATOM    456  O   VAL A  55     -13.976  -3.197  -7.273  1.00 97.96           O  \\nATOM    457  CG1 VAL A  55     -11.705  -0.649  -6.447  1.00 97.96           C  \\nATOM    458  CG2 VAL A  55     -10.646  -0.705  -8.668  1.00 97.96           C  \\nATOM    459  N   LYS A  56     -12.530  -4.278  -5.941  1.00 96.50           N  \\nATOM    460  CA  LYS A  56     -13.550  -5.134  -5.313  1.00 96.50           C  \\nATOM    461  C   LYS A  56     -14.473  -4.424  -4.333  1.00 96.50           C  \\nATOM    462  CB  LYS A  56     -12.904  -6.376  -4.671  1.00 96.50           C  \\nATOM    463  O   LYS A  56     -15.584  -4.899  -4.154  1.00 96.50           O  \\nATOM    464  CG  LYS A  56     -12.315  -7.385  -5.673  1.00 96.50           C  \\nATOM    465  CD  LYS A  56     -13.367  -7.817  -6.703  1.00 96.50           C  \\nATOM    466  CE  LYS A  56     -12.935  -8.980  -7.592  1.00 96.50           C  \\nATOM    467  NZ  LYS A  56     -13.856  -9.035  -8.747  1.00 96.50           N  \\nATOM    468  N   MET A  57     -14.066  -3.310  -3.723  1.00 97.70           N  \\nATOM    469  CA  MET A  57     -14.947  -2.531  -2.834  1.00 97.70           C  \\nATOM    470  C   MET A  57     -15.571  -3.386  -1.714  1.00 97.70           C  \\nATOM    471  CB  MET A  57     -16.010  -1.790  -3.662  1.00 97.70           C  \\nATOM    472  O   MET A  57     -16.782  -3.403  -1.502  1.00 97.70           O  \\nATOM    473  CG  MET A  57     -15.395  -0.943  -4.777  1.00 97.70           C  \\nATOM    474  SD  MET A  57     -14.324   0.396  -4.201  1.00 97.70           S  \\nATOM    475  CE  MET A  57     -15.610   1.486  -3.570  1.00 97.70           C  \\nATOM    476  N   LEU A  58     -14.726  -4.130  -1.004  1.00 97.01           N  \\nATOM    477  CA  LEU A  58     -15.116  -5.101   0.011  1.00 97.01           C  \\nATOM    478  C   LEU A  58     -15.724  -4.408   1.251  1.00 97.01           C  \\nATOM    479  CB  LEU A  58     -13.899  -5.967   0.387  1.00 97.01           C  \\nATOM    480  O   LEU A  58     -15.044  -3.600   1.897  1.00 97.01           O  \\nATOM    481  CG  LEU A  58     -13.298  -6.764  -0.787  1.00 97.01           C  \\nATOM    482  CD1 LEU A  58     -12.066  -7.538  -0.324  1.00 97.01           C  \\nATOM    483  CD2 LEU A  58     -14.282  -7.783  -1.368  1.00 97.01           C  \\nATOM    484  N   PRO A  59     -16.971  -4.741   1.637  1.00 95.88           N  \\nATOM    485  CA  PRO A  59     -17.580  -4.255   2.871  1.00 95.88           C  \\nATOM    486  C   PRO A  59     -16.829  -4.772   4.102  1.00 95.88           C  \\nATOM    487  CB  PRO A  59     -19.030  -4.756   2.850  1.00 95.88           C  \\nATOM    488  O   PRO A  59     -16.488  -5.951   4.181  1.00 95.88           O  \\nATOM    489  CG  PRO A  59     -19.295  -5.096   1.388  1.00 95.88           C  \\nATOM    490  CD  PRO A  59     -17.930  -5.538   0.889  1.00 95.88           C  \\nATOM    491  N   THR A  60     -16.590  -3.901   5.083  1.00 94.13           N  \\nATOM    492  CA  THR A  60     -15.776  -4.238   6.271  1.00 94.13           C  \\nATOM    493  C   THR A  60     -16.601  -4.481   7.534  1.00 94.13           C  \\nATOM    494  CB  THR A  60     -14.750  -3.138   6.570  1.00 94.13           C  \\nATOM    495  O   THR A  60     -16.049  -4.866   8.559  1.00 94.13           O  \\nATOM    496  CG2 THR A  60     -13.894  -2.757   5.358  1.00 94.13           C  \\nATOM    497  OG1 THR A  60     -15.425  -1.990   7.022  1.00 94.13           O  \\nATOM    498  N   TYR A  61     -17.911  -4.207   7.490  1.00 91.04           N  \\nATOM    499  CA  TYR A  61     -18.823  -4.220   8.645  1.00 91.04           C  \\nATOM    500  C   TYR A  61     -18.483  -3.207   9.758  1.00 91.04           C  \\nATOM    501  CB  TYR A  61     -19.043  -5.656   9.153  1.00 91.04           C  \\nATOM    502  O   TYR A  61     -19.196  -3.114  10.759  1.00 91.04           O  \\nATOM    503  CG  TYR A  61     -19.774  -6.539   8.160  1.00 91.04           C  \\nATOM    504  CD1 TYR A  61     -21.134  -6.842   8.361  1.00 91.04           C  \\nATOM    505  CD2 TYR A  61     -19.104  -7.046   7.030  1.00 91.04           C  \\nATOM    506  CE1 TYR A  61     -21.821  -7.648   7.434  1.00 91.04           C  \\nATOM    507  CE2 TYR A  61     -19.789  -7.843   6.096  1.00 91.04           C  \\nATOM    508  OH  TYR A  61     -21.814  -8.925   5.407  1.00 91.04           O  \\nATOM    509  CZ  TYR A  61     -21.149  -8.153   6.303  1.00 91.04           C  \\nATOM    510  N   VAL A  62     -17.481  -2.344   9.558  1.00 91.59           N  \\nATOM    511  CA  VAL A  62     -17.222  -1.187  10.424  1.00 91.59           C  \\nATOM    512  C   VAL A  62     -18.175  -0.053  10.032  1.00 91.59           C  \\nATOM    513  CB  VAL A  62     -15.738  -0.771  10.376  1.00 91.59           C  \\nATOM    514  O   VAL A  62     -17.945   0.675   9.069  1.00 91.59           O  \\nATOM    515  CG1 VAL A  62     -15.459   0.405  11.322  1.00 91.59           C  \\nATOM    516  CG2 VAL A  62     -14.833  -1.935  10.802  1.00 91.59           C  \\nATOM    517  N   ARG A  63     -19.286   0.073  10.770  1.00 87.26           N  \\nATOM    518  CA  ARG A  63     -20.339   1.089  10.536  1.00 87.26           C  \\nATOM    519  C   ARG A  63     -20.217   2.362  11.379  1.00 87.26           C  \\nATOM    520  CB  ARG A  63     -21.736   0.472  10.719  1.00 87.26           C  \\nATOM    521  O   ARG A  63     -20.993   3.294  11.211  1.00 87.26           O  \\nATOM    522  CG  ARG A  63     -22.088  -0.584   9.661  1.00 87.26           C  \\nATOM    523  CD  ARG A  63     -23.600  -0.862   9.701  1.00 87.26           C  \\nATOM    524  NE  ARG A  63     -24.023  -1.873   8.709  1.00 87.26           N  \\nATOM    525  NH1 ARG A  63     -26.202  -1.170   8.417  1.00 87.26           N  \\nATOM    526  NH2 ARG A  63     -25.471  -2.943   7.295  1.00 87.26           N  \\nATOM    527  CZ  ARG A  63     -25.223  -1.987   8.150  1.00 87.26           C  \\nATOM    528  N   SER A  64     -19.302   2.396  12.341  1.00 76.94           N  \\nATOM    529  CA  SER A  64     -19.133   3.550  13.224  1.00 76.94           C  \\nATOM    530  C   SER A  64     -17.683   3.716  13.624  1.00 76.94           C  \\nATOM    531  CB  SER A  64     -20.005   3.435  14.479  1.00 76.94           C  \\nATOM    532  O   SER A  64     -16.933   2.746  13.721  1.00 76.94           O  \\nATOM    533  OG  SER A  64     -19.666   2.271  15.213  1.00 76.94           O  \\nATOM    534  N   THR A  65     -17.331   4.955  13.904  1.00 77.74           N  \\nATOM    535  CA  THR A  65     -16.035   5.368  14.414  1.00 77.74           C  \\nATOM    536  C   THR A  65     -16.079   5.503  15.945  1.00 77.74           C  \\nATOM    537  CB  THR A  65     -15.667   6.687  13.740  1.00 77.74           C  \\nATOM    538  O   THR A  65     -17.174   5.533  16.515  1.00 77.74           O  \\nATOM    539  CG2 THR A  65     -15.401   6.501  12.244  1.00 77.74           C  \\nATOM    540  OG1 THR A  65     -16.749   7.586  13.853  1.00 77.74           O  \\nATOM    541  N   PRO A  66     -14.924   5.525  16.637  1.00 79.65           N  \\nATOM    542  CA  PRO A  66     -14.876   5.750  18.081  1.00 79.65           C  \\nATOM    543  C   PRO A  66     -15.467   7.112  18.462  1.00 79.65           C  \\nATOM    544  CB  PRO A  66     -13.398   5.646  18.475  1.00 79.65           C  \\nATOM    545  O   PRO A  66     -15.230   8.100  17.771  1.00 79.65           O  \\nATOM    546  CG  PRO A  66     -12.774   4.842  17.337  1.00 79.65           C  \\nATOM    547  CD  PRO A  66     -13.591   5.269  16.122  1.00 79.65           C  \\nATOM    548  N   GLU A  67     -16.199   7.167  19.575  1.00 79.31           N  \\nATOM    549  CA  GLU A  67     -16.833   8.391  20.097  1.00 79.31           C  \\nATOM    550  C   GLU A  67     -16.007   9.057  21.213  1.00 79.31           C  \\nATOM    551  CB  GLU A  67     -18.242   8.056  20.616  1.00 79.31           C  \\nATOM    552  O   GLU A  67     -16.404  10.090  21.749  1.00 79.31           O  \\nATOM    553  CG  GLU A  67     -19.219   7.584  19.525  1.00 79.31           C  \\nATOM    554  CD  GLU A  67     -20.558   7.084  20.099  1.00 79.31           C  \\nATOM    555  OE1 GLU A  67     -21.512   6.938  19.303  1.00 79.31           O  \\nATOM    556  OE2 GLU A  67     -20.624   6.761  21.318  1.00 79.31           O  \\nATOM    557  N   GLY A  68     -14.886   8.448  21.618  1.00 76.31           N  \\nATOM    558  CA  GLY A  68     -14.038   8.944  22.706  1.00 76.31           C  \\nATOM    559  C   GLY A  68     -14.556   8.575  24.098  1.00 76.31           C  \\nATOM    560  O   GLY A  68     -14.277   9.278  25.062  1.00 76.31           O  \\nATOM    561  N   SER A  69     -15.331   7.492  24.205  1.00 77.45           N  \\nATOM    562  CA  SER A  69     -15.860   6.959  25.477  1.00 77.45           C  \\nATOM    563  C   SER A  69     -15.552   5.466  25.691  1.00 77.45           C  \\nATOM    564  CB  SER A  69     -17.353   7.265  25.621  1.00 77.45           C  \\nATOM    565  O   SER A  69     -15.996   4.858  26.665  1.00 77.45           O  \\nATOM    566  OG  SER A  69     -18.058   6.876  24.459  1.00 77.45           O  \\nATOM    567  N   GLU A  70     -14.769   4.855  24.802  1.00 81.98           N  \\nATOM    568  CA  GLU A  70     -14.397   3.437  24.791  1.00 81.98           C  \\nATOM    569  C   GLU A  70     -13.254   3.054  25.764  1.00 81.98           C  \\nATOM    570  CB  GLU A  70     -13.967   3.063  23.360  1.00 81.98           C  \\nATOM    571  O   GLU A  70     -12.089   3.049  25.379  1.00 81.98           O  \\nATOM    572  CG  GLU A  70     -15.023   3.168  22.256  1.00 81.98           C  \\nATOM    573  CD  GLU A  70     -15.331   4.593  21.777  1.00 81.98           C  \\nATOM    574  OE1 GLU A  70     -16.377   4.747  21.115  1.00 81.98           O  \\nATOM    575  OE2 GLU A  70     -14.595   5.552  22.108  1.00 81.98           O  \\nATOM    576  N   VAL A  71     -13.518   2.735  27.032  1.00 83.64           N  \\nATOM    577  CA  VAL A  71     -12.443   2.400  27.997  1.00 83.64           C  \\nATOM    578  C   VAL A  71     -12.064   0.913  27.945  1.00 83.64           C  \\nATOM    579  CB  VAL A  71     -12.817   2.795  29.439  1.00 83.64           C  \\nATOM    580  O   VAL A  71     -12.943   0.053  27.919  1.00 83.64           O  \\nATOM    581  CG1 VAL A  71     -11.619   2.687  30.393  1.00 83.64           C  \\nATOM    582  CG2 VAL A  71     -13.319   4.234  29.549  1.00 83.64           C  \\nATOM    583  N   GLY A  72     -10.770   0.584  28.022  1.00 88.91           N  \\nATOM    584  CA  GLY A  72     -10.309  -0.789  28.249  1.00 88.91           C  \\nATOM    585  C   GLY A  72      -8.846  -1.065  27.890  1.00 88.91           C  \\nATOM    586  O   GLY A  72      -8.173  -0.271  27.234  1.00 88.91           O  \\nATOM    587  N   ASP A  73      -8.368  -2.236  28.315  1.00 92.05           N  \\nATOM    588  CA  ASP A  73      -7.118  -2.832  27.840  1.00 92.05           C  \\nATOM    589  C   ASP A  73      -7.459  -3.810  26.700  1.00 92.05           C  \\nATOM    590  CB  ASP A  73      -6.383  -3.571  28.983  1.00 92.05           C  \\nATOM    591  O   ASP A  73      -8.223  -4.757  26.895  1.00 92.05           O  \\nATOM    592  CG  ASP A  73      -5.624  -2.716  30.018  1.00 92.05           C  \\nATOM    593  OD1 ASP A  73      -5.597  -1.472  29.961  1.00 92.05           O  \\nATOM    594  OD2 ASP A  73      -4.913  -3.303  30.879  1.00 92.05           O  \\nATOM    595  N   PHE A  74      -6.861  -3.608  25.531  1.00 93.99           N  \\nATOM    596  CA  PHE A  74      -7.079  -4.404  24.326  1.00 93.99           C  \\nATOM    597  C   PHE A  74      -5.754  -4.954  23.833  1.00 93.99           C  \\nATOM    598  CB  PHE A  74      -7.728  -3.539  23.239  1.00 93.99           C  \\nATOM    599  O   PHE A  74      -4.723  -4.282  23.914  1.00 93.99           O  \\nATOM    600  CG  PHE A  74      -9.064  -2.971  23.657  1.00 93.99           C  \\nATOM    601  CD1 PHE A  74     -10.238  -3.707  23.430  1.00 93.99           C  \\nATOM    602  CD2 PHE A  74      -9.127  -1.737  24.331  1.00 93.99           C  \\nATOM    603  CE1 PHE A  74     -11.470  -3.238  23.917  1.00 93.99           C  \\nATOM    604  CE2 PHE A  74     -10.361  -1.257  24.799  1.00 93.99           C  \\nATOM    605  CZ  PHE A  74     -11.527  -2.018  24.615  1.00 93.99           C  \\nATOM    606  N   LEU A  75      -5.773  -6.161  23.283  1.00 95.28           N  \\nATOM    607  CA  LEU A  75      -4.649  -6.628  22.492  1.00 95.28           C  \\nATOM    608  C   LEU A  75      -4.947  -6.369  21.013  1.00 95.28           C  \\nATOM    609  CB  LEU A  75      -4.331  -8.085  22.851  1.00 95.28           C  \\nATOM    610  O   LEU A  75      -6.089  -6.499  20.572  1.00 95.28           O  \\nATOM    611  CG  LEU A  75      -2.882  -8.445  22.470  1.00 95.28           C  \\nATOM    612  CD1 LEU A  75      -1.900  -8.001  23.553  1.00 95.28           C  \\nATOM    613  CD2 LEU A  75      -2.681  -9.938  22.360  1.00 95.28           C  \\nATOM    614  N   SER A  76      -3.931  -6.012  20.237  1.00 95.61           N  \\nATOM    615  CA  SER A  76      -4.033  -5.981  18.787  1.00 95.61           C  \\nATOM    616  C   SER A  76      -2.896  -6.725  18.111  1.00 95.61           C  \\nATOM    617  CB  SER A  76      -4.230  -4.574  18.231  1.00 95.61           C  \\nATOM    618  O   SER A  76      -1.756  -6.741  18.581  1.00 95.61           O  \\nATOM    619  OG  SER A  76      -3.089  -3.765  18.374  1.00 95.61           O  \\nATOM    620  N   LEU A  77      -3.244  -7.384  17.014  1.00 96.38           N  \\nATOM    621  CA  LEU A  77      -2.316  -8.068  16.129  1.00 96.38           C  \\nATOM    622  C   LEU A  77      -2.283  -7.327  14.804  1.00 96.38           C  \\nATOM    623  CB  LEU A  77      -2.747  -9.521  15.897  1.00 96.38           C  \\nATOM    624  O   LEU A  77      -3.315  -6.857  14.337  1.00 96.38           O  \\nATOM    625  CG  LEU A  77      -3.104 -10.321  17.144  1.00 96.38           C  \\nATOM    626  CD1 LEU A  77      -3.460 -11.745  16.730  1.00 96.38           C  \\nATOM    627  CD2 LEU A  77      -1.993 -10.351  18.196  1.00 96.38           C  \\nATOM    628  N   ASP A  78      -1.118  -7.268  14.185  1.00 95.07           N  \\nATOM    629  CA  ASP A  78      -0.927  -6.636  12.888  1.00 95.07           C  \\nATOM    630  C   ASP A  78      -0.044  -7.537  12.030  1.00 95.07           C  \\nATOM    631  CB  ASP A  78      -0.362  -5.237  13.139  1.00 95.07           C  \\nATOM    632  O   ASP A  78       1.164  -7.654  12.260  1.00 95.07           O  \\nATOM    633  CG  ASP A  78       0.032  -4.477  11.881  1.00 95.07           C  \\nATOM    634  OD1 ASP A  78      -0.519  -4.754  10.800  1.00 95.07           O  \\nATOM    635  OD2 ASP A  78       0.832  -3.522  12.050  1.00 95.07           O  \\nATOM    636  N   LEU A  79      -0.681  -8.242  11.093  1.00 93.13           N  \\nATOM    637  CA  LEU A  79      -0.012  -9.096  10.120  1.00 93.13           C  \\nATOM    638  C   LEU A  79       0.145  -8.339   8.800  1.00 93.13           C  \\nATOM    639  CB  LEU A  79      -0.771 -10.425   9.972  1.00 93.13           C  \\nATOM    640  O   LEU A  79      -0.722  -8.394   7.924  1.00 93.13           O  \\nATOM    641  CG  LEU A  79      -0.013 -11.436   9.091  1.00 93.13           C  \\nATOM    642  CD1 LEU A  79       1.190 -12.021   9.827  1.00 93.13           C  \\nATOM    643  CD2 LEU A  79      -0.933 -12.586   8.706  1.00 93.13           C  \\nATOM    644  N   GLY A  80       1.280  -7.652   8.675  1.00 85.19           N  \\nATOM    645  CA  GLY A  80       1.659  -6.927   7.470  1.00 85.19           C  \\nATOM    646  C   GLY A  80       2.419  -7.789   6.457  1.00 85.19           C  \\nATOM    647  O   GLY A  80       2.668  -8.977   6.645  1.00 85.19           O  \\nATOM    648  N   GLY A  81       2.875  -7.157   5.372  1.00 75.33           N  \\nATOM    649  CA  GLY A  81       3.600  -7.838   4.290  1.00 75.33           C  \\nATOM    650  C   GLY A  81       5.038  -8.277   4.616  1.00 75.33           C  \\nATOM    651  O   GLY A  81       5.711  -8.816   3.743  1.00 75.33           O  \\nATOM    652  N   THR A  82       5.557  -7.988   5.813  1.00 73.91           N  \\nATOM    653  CA  THR A  82       6.976  -8.230   6.165  1.00 73.91           C  \\nATOM    654  C   THR A  82       7.170  -8.543   7.645  1.00 73.91           C  \\nATOM    655  CB  THR A  82       7.843  -7.008   5.798  1.00 73.91           C  \\nATOM    656  O   THR A  82       7.963  -9.412   7.993  1.00 73.91           O  \\nATOM    657  CG2 THR A  82       9.343  -7.261   5.950  1.00 73.91           C  \\nATOM    658  OG1 THR A  82       7.611  -6.630   4.456  1.00 73.91           O  \\nATOM    659  N   ASN A  83       6.440  -7.854   8.522  1.00 86.23           N  \\nATOM    660  CA  ASN A  83       6.534  -8.038   9.964  1.00 86.23           C  \\nATOM    661  C   ASN A  83       5.169  -8.405  10.533  1.00 86.23           C  \\nATOM    662  CB  ASN A  83       7.091  -6.765  10.620  1.00 86.23           C  \\nATOM    663  O   ASN A  83       4.136  -7.944  10.043  1.00 86.23           O  \\nATOM    664  CG  ASN A  83       8.489  -6.420  10.141  1.00 86.23           C  \\nATOM    665  ND2 ASN A  83       8.726  -5.183   9.773  1.00 86.23           N  \\nATOM    666  OD1 ASN A  83       9.390  -7.238  10.093  1.00 86.23           O  \\nATOM    667  N   PHE A  84       5.202  -9.186  11.602  1.00 93.95           N  \\nATOM    668  CA  PHE A  84       4.079  -9.391  12.493  1.00 93.95           C  \\nATOM    669  C   PHE A  84       4.289  -8.557  13.754  1.00 93.95           C  \\nATOM    670  CB  PHE A  84       3.947 -10.882  12.805  1.00 93.95           C  \\nATOM    671  O   PHE A  84       5.397  -8.501  14.291  1.00 93.95           O  \\nATOM    672  CG  PHE A  84       2.811 -11.175  13.754  1.00 93.95           C  \\nATOM    673  CD1 PHE A  84       3.058 -11.722  15.026  1.00 93.95           C  \\nATOM    674  CD2 PHE A  84       1.497 -10.868  13.362  1.00 93.95           C  \\nATOM    675  CE1 PHE A  84       1.982 -11.957  15.899  1.00 93.95           C  \\nATOM    676  CE2 PHE A  84       0.427 -11.111  14.231  1.00 93.95           C  \\nATOM    677  CZ  PHE A  84       0.672 -11.645  15.504  1.00 93.95           C  \\nATOM    678  N   ARG A  85       3.247  -7.892  14.241  1.00 94.81           N  \\nATOM    679  CA  ARG A  85       3.332  -7.064  15.443  1.00 94.81           C  \\nATOM    680  C   ARG A  85       2.214  -7.413  16.412  1.00 94.81           C  \\nATOM    681  CB  ARG A  85       3.386  -5.592  15.019  1.00 94.81           C  \\nATOM    682  O   ARG A  85       1.058  -7.528  16.021  1.00 94.81           O  \\nATOM    683  CG  ARG A  85       3.421  -4.616  16.203  1.00 94.81           C  \\nATOM    684  CD  ARG A  85       3.621  -3.170  15.740  1.00 94.81           C  \\nATOM    685  NE  ARG A  85       2.551  -2.727  14.831  1.00 94.81           N  \\nATOM    686  NH1 ARG A  85       2.901  -0.465  15.004  1.00 94.81           N  \\nATOM    687  NH2 ARG A  85       1.274  -1.265  13.703  1.00 94.81           N  \\nATOM    688  CZ  ARG A  85       2.247  -1.485  14.525  1.00 94.81           C  \\nATOM    689  N   VAL A  86       2.580  -7.543  17.683  1.00 95.89           N  \\nATOM    690  CA  VAL A  86       1.651  -7.722  18.804  1.00 95.89           C  \\nATOM    691  C   VAL A  86       1.692  -6.456  19.646  1.00 95.89           C  \\nATOM    692  CB  VAL A  86       2.003  -8.958  19.655  1.00 95.89           C  \\nATOM    693  O   VAL A  86       2.780  -5.970  19.970  1.00 95.89           O  \\nATOM    694  CG1 VAL A  86       0.912  -9.222  20.701  1.00 95.89           C  \\nATOM    695  CG2 VAL A  86       2.147 -10.224  18.803  1.00 95.89           C  \\nATOM    696  N   MET A  87       0.529  -5.904  19.985  1.00 94.97           N  \\nATOM    697  CA  MET A  87       0.415  -4.683  20.776  1.00 94.97           C  \\nATOM    698  C   MET A  87      -0.579  -4.839  21.918  1.00 94.97           C  \\nATOM    699  CB  MET A  87       0.029  -3.467  19.920  1.00 94.97           C  \\nATOM    700  O   MET A  87      -1.655  -5.398  21.750  1.00 94.97           O  \\nATOM    701  CG  MET A  87       0.864  -3.339  18.644  1.00 94.97           C  \\nATOM    702  SD  MET A  87       0.705  -1.824  17.654  1.00 94.97           S  \\nATOM    703  CE  MET A  87       0.605  -0.482  18.868  1.00 94.97           C  \\nATOM    704  N   LEU A  88      -0.239  -4.282  23.074  1.00 94.38           N  \\nATOM    705  CA  LEU A  88      -1.184  -3.960  24.134  1.00 94.38           C  \\nATOM    706  C   LEU A  88      -1.552  -2.487  23.998  1.00 94.38           C  \\nATOM    707  CB  LEU A  88      -0.542  -4.265  25.494  1.00 94.38           C  \\nATOM    708  O   LEU A  88      -0.677  -1.623  24.088  1.00 94.38           O  \\nATOM    709  CG  LEU A  88      -1.435  -3.908  26.697  1.00 94.38           C  \\nATOM    710  CD1 LEU A  88      -2.645  -4.832  26.821  1.00 94.38           C  \\nATOM    711  CD2 LEU A  88      -0.604  -4.001  27.979  1.00 94.38           C  \\nATOM    712  N   VAL A  89      -2.836  -2.211  23.826  1.00 92.51           N  \\nATOM    713  CA  VAL A  89      -3.389  -0.868  23.693  1.00 92.51           C  \\nATOM    714  C   VAL A  89      -4.299  -0.605  24.881  1.00 92.51           C  \\nATOM    715  CB  VAL A  89      -4.144  -0.711  22.363  1.00 92.51           C  \\nATOM    716  O   VAL A  89      -5.257  -1.334  25.120  1.00 92.51           O  \\nATOM    717  CG1 VAL A  89      -4.593   0.742  22.180  1.00 92.51           C  \\nATOM    718  CG2 VAL A  89      -3.265  -1.101  21.165  1.00 92.51           C  \\nATOM    719  N   LYS A  90      -3.989   0.436  25.645  1.00 90.91           N  \\nATOM    720  CA  LYS A  90      -4.807   0.892  26.766  1.00 90.91           C  \\nATOM    721  C   LYS A  90      -5.536   2.152  26.353  1.00 90.91           C  \\nATOM    722  CB  LYS A  90      -3.947   1.139  28.001  1.00 90.91           C  \\nATOM    723  O   LYS A  90      -4.880   3.149  26.052  1.00 90.91           O  \\nATOM    724  CG  LYS A  90      -3.127  -0.098  28.367  1.00 90.91           C  \\nATOM    725  CD  LYS A  90      -2.585   0.066  29.783  1.00 90.91           C  \\nATOM    726  CE  LYS A  90      -2.041  -1.277  30.255  1.00 90.91           C  \\nATOM    727  NZ  LYS A  90      -2.758  -1.692  31.472  1.00 90.91           N  \\nATOM    728  N   VAL A  91      -6.858   2.088  26.338  1.00 87.42           N  \\nATOM    729  CA  VAL A  91      -7.745   3.178  25.941  1.00 87.42           C  \\nATOM    730  C   VAL A  91      -8.497   3.657  27.181  1.00 87.42           C  \\nATOM    731  CB  VAL A  91      -8.708   2.713  24.828  1.00 87.42           C  \\nATOM    732  O   VAL A  91      -9.071   2.846  27.907  1.00 87.42           O  \\nATOM    733  CG1 VAL A  91      -9.447   3.918  24.253  1.00 87.42           C  \\nATOM    734  CG2 VAL A  91      -7.986   2.032  23.655  1.00 87.42           C  \\nATOM    735  N   GLY A  92      -8.473   4.957  27.466  1.00 83.02           N  \\nATOM    736  CA  GLY A  92      -9.228   5.527  28.583  1.00 83.02           C  \\nATOM    737  C   GLY A  92      -8.793   6.936  28.972  1.00 83.02           C  \\nATOM    738  O   GLY A  92      -7.907   7.524  28.350  1.00 83.02           O  \\nATOM    739  N   GLU A  93      -9.405   7.467  30.030  1.00 67.59           N  \\nATOM    740  CA  GLU A  93      -9.097   8.799  30.558  1.00 67.59           C  \\nATOM    741  C   GLU A  93      -7.637   8.892  31.036  1.00 67.59           C  \\nATOM    742  CB  GLU A  93     -10.073   9.182  31.683  1.00 67.59           C  \\nATOM    743  O   GLU A  93      -7.160   8.097  31.850  1.00 67.59           O  \\nATOM    744  CG  GLU A  93     -11.504   9.412  31.162  1.00 67.59           C  \\nATOM    745  CD  GLU A  93     -12.493   9.859  32.256  1.00 67.59           C  \\nATOM    746  OE1 GLU A  93     -13.673  10.080  31.905  1.00 67.59           O  \\nATOM    747  OE2 GLU A  93     -12.086   9.947  33.438  1.00 67.59           O  \\nATOM    748  N   GLY A  94      -6.906   9.858  30.484  1.00 63.49           N  \\nATOM    749  CA  GLY A  94      -5.564  10.235  30.909  1.00 63.49           C  \\nATOM    750  C   GLY A  94      -5.568  11.108  32.168  1.00 63.49           C  \\nATOM    751  O   GLY A  94      -6.610  11.432  32.732  1.00 63.49           O  \\nATOM    752  N   GLU A  95      -4.376  11.519  32.605  1.00 60.01           N  \\nATOM    753  CA  GLU A  95      -4.169  12.233  33.880  1.00 60.01           C  \\nATOM    754  C   GLU A  95      -4.857  13.610  33.942  1.00 60.01           C  \\nATOM    755  CB  GLU A  95      -2.655  12.364  34.144  1.00 60.01           C  \\nATOM    756  O   GLU A  95      -5.232  14.056  35.023  1.00 60.01           O  \\nATOM    757  CG  GLU A  95      -2.016  10.999  34.460  1.00 60.01           C  \\nATOM    758  CD  GLU A  95      -0.484  11.015  34.594  1.00 60.01           C  \\nATOM    759  OE1 GLU A  95       0.085   9.894  34.546  1.00 60.01           O  \\nATOM    760  OE2 GLU A  95       0.116  12.104  34.706  1.00 60.01           O  \\nATOM    761  N   GLU A  96      -5.076  14.261  32.797  1.00 61.24           N  \\nATOM    762  CA  GLU A  96      -5.698  15.592  32.699  1.00 61.24           C  \\nATOM    763  C   GLU A  96      -7.176  15.542  32.264  1.00 61.24           C  \\nATOM    764  CB  GLU A  96      -4.857  16.499  31.783  1.00 61.24           C  \\nATOM    765  O   GLU A  96      -7.721  16.532  31.780  1.00 61.24           O  \\nATOM    766  CG  GLU A  96      -3.432  16.721  32.318  1.00 61.24           C  \\nATOM    767  CD  GLU A  96      -2.623  17.735  31.490  1.00 61.24           C  \\nATOM    768  OE1 GLU A  96      -1.516  18.093  31.955  1.00 61.24           O  \\nATOM    769  OE2 GLU A  96      -3.105  18.160  30.415  1.00 61.24           O  \\nATOM    770  N   GLY A  97      -7.827  14.376  32.362  1.00 58.18           N  \\nATOM    771  CA  GLY A  97      -9.180  14.163  31.826  1.00 58.18           C  \\nATOM    772  C   GLY A  97      -9.241  14.126  30.292  1.00 58.18           C  \\nATOM    773  O   GLY A  97     -10.313  13.956  29.719  1.00 58.18           O  \\nATOM    774  N   GLN A  98      -8.097  14.260  29.612  1.00 64.07           N  \\nATOM    775  CA  GLN A  98      -7.980  14.019  28.178  1.00 64.07           C  \\nATOM    776  C   GLN A  98      -7.915  12.522  27.916  1.00 64.07           C  \\nATOM    777  CB  GLN A  98      -6.740  14.699  27.590  1.00 64.07           C  \\nATOM    778  O   GLN A  98      -7.146  11.802  28.554  1.00 64.07           O  \\nATOM    779  CG  GLN A  98      -6.845  16.228  27.634  1.00 64.07           C  \\nATOM    780  CD  GLN A  98      -5.653  16.912  26.973  1.00 64.07           C  \\nATOM    781  NE2 GLN A  98      -5.462  18.187  27.212  1.00 64.07           N  \\nATOM    782  OE1 GLN A  98      -4.873  16.329  26.239  1.00 64.07           O  \\nATOM    783  N   TRP A  99      -8.696  12.052  26.955  1.00 69.84           N  \\nATOM    784  CA  TRP A  99      -8.648  10.664  26.529  1.00 69.84           C  \\nATOM    785  C   TRP A  99      -7.264  10.308  25.981  1.00 69.84           C  \\nATOM    786  CB  TRP A  99      -9.739  10.436  25.498  1.00 69.84           C  \\nATOM    787  O   TRP A  99      -6.682  11.051  25.188  1.00 69.84           O  \\nATOM    788  CG  TRP A  99     -10.150   9.015  25.386  1.00 69.84           C  \\nATOM    789  CD1 TRP A  99      -9.580   8.013  24.675  1.00 69.84           C  \\nATOM    790  CD2 TRP A  99     -11.203   8.393  26.155  1.00 69.84           C  \\nATOM    791  CE2 TRP A  99     -11.328   7.061  25.701  1.00 69.84           C  \\nATOM    792  CE3 TRP A  99     -12.035   8.802  27.216  1.00 69.84           C  \\nATOM    793  NE1 TRP A  99     -10.362   6.896  24.752  1.00 69.84           N  \\nATOM    794  CH2 TRP A  99     -13.103   6.625  27.263  1.00 69.84           C  \\nATOM    795  CZ2 TRP A  99     -12.271   6.206  26.224  1.00 69.84           C  \\nATOM    796  CZ3 TRP A  99     -12.973   7.920  27.776  1.00 69.84           C  \\nATOM    797  N   SER A 100      -6.716   9.176  26.417  1.00 78.58           N  \\nATOM    798  CA  SER A 100      -5.363   8.749  26.077  1.00 78.58           C  \\nATOM    799  C   SER A 100      -5.345   7.323  25.543  1.00 78.58           C  \\nATOM    800  CB  SER A 100      -4.414   8.943  27.268  1.00 78.58           C  \\nATOM    801  O   SER A 100      -6.096   6.453  25.990  1.00 78.58           O  \\nATOM    802  OG  SER A 100      -4.623   7.989  28.295  1.00 78.58           O  \\nATOM    803  N   VAL A 101      -4.451   7.088  24.584  1.00 82.75           N  \\nATOM    804  CA  VAL A 101      -4.159   5.758  24.055  1.00 82.75           C  \\nATOM    805  C   VAL A 101      -2.692   5.457  24.334  1.00 82.75           C  \\nATOM    806  CB  VAL A 101      -4.513   5.643  22.562  1.00 82.75           C  \\nATOM    807  O   VAL A 101      -1.807   6.075  23.749  1.00 82.75           O  \\nATOM    808  CG1 VAL A 101      -4.293   4.201  22.105  1.00 82.75           C  \\nATOM    809  CG2 VAL A 101      -5.985   5.997  22.300  1.00 82.75           C  \\nATOM    810  N   LYS A 102      -2.423   4.536  25.264  1.00 86.97           N  \\nATOM    811  CA  LYS A 102      -1.056   4.106  25.604  1.00 86.97           C  \\nATOM    812  C   LYS A 102      -0.782   2.746  24.979  1.00 86.97           C  \\nATOM    813  CB  LYS A 102      -0.831   4.095  27.128  1.00 86.97           C  \\nATOM    814  O   LYS A 102      -1.544   1.807  25.209  1.00 86.97           O  \\nATOM    815  CG  LYS A 102      -0.908   5.500  27.749  1.00 86.97           C  \\nATOM    816  CD  LYS A 102      -0.643   5.494  29.266  1.00 86.97           C  \\nATOM    817  CE  LYS A 102      -0.780   6.930  29.805  1.00 86.97           C  \\nATOM    818  NZ  LYS A 102      -0.582   7.047  31.278  1.00 86.97           N  \\nATOM    819  N   THR A 103       0.319   2.621  24.244  1.00 90.69           N  \\nATOM    820  CA  THR A 103       0.684   1.382  23.552  1.00 90.69           C  \\nATOM    821  C   THR A 103       1.960   0.762  24.123  1.00 90.69           C  \\nATOM    822  CB  THR A 103       0.774   1.580  22.028  1.00 90.69           C  \\nATOM    823  O   THR A 103       2.858   1.438  24.628  1.00 90.69           O  \\nATOM    824  CG2 THR A 103      -0.538   2.111  21.447  1.00 90.69           C  \\nATOM    825  OG1 THR A 103       1.787   2.495  21.715  1.00 90.69           O  \\nATOM    826  N   LYS A 104       2.033  -0.568  24.075  1.00 92.29           N  \\nATOM    827  CA  LYS A 104       3.275  -1.346  24.165  1.00 92.29           C  \\nATOM    828  C   LYS A 104       3.258  -2.337  23.021  1.00 92.29           C  \\nATOM    829  CB  LYS A 104       3.378  -2.110  25.491  1.00 92.29           C  \\nATOM    830  O   LYS A 104       2.251  -3.019  22.861  1.00 92.29           O  \\nATOM    831  CG  LYS A 104       3.511  -1.192  26.706  1.00 92.29           C  \\nATOM    832  CD  LYS A 104       3.719  -2.047  27.958  1.00 92.29           C  \\nATOM    833  CE  LYS A 104       3.883  -1.142  29.178  1.00 92.29           C  \\nATOM    834  NZ  LYS A 104       4.209  -1.941  30.384  1.00 92.29           N  \\nATOM    835  N   HIS A 105       4.337  -2.449  22.260  1.00 93.29           N  \\nATOM    836  CA  HIS A 105       4.371  -3.336  21.104  1.00 93.29           C  \\nATOM    837  C   HIS A 105       5.654  -4.157  21.033  1.00 93.29           C  \\nATOM    838  CB  HIS A 105       4.129  -2.526  19.823  1.00 93.29           C  \\nATOM    839  O   HIS A 105       6.687  -3.784  21.587  1.00 93.29           O  \\nATOM    840  CG  HIS A 105       5.251  -1.604  19.433  1.00 93.29           C  \\nATOM    841  CD2 HIS A 105       6.396  -1.977  18.783  1.00 93.29           C  \\nATOM    842  ND1 HIS A 105       5.304  -0.236  19.591  1.00 93.29           N  \\nATOM    843  CE1 HIS A 105       6.458   0.191  19.059  1.00 93.29           C  \\nATOM    844  NE2 HIS A 105       7.160  -0.835  18.551  1.00 93.29           N  \\nATOM    845  N   GLN A 106       5.584  -5.267  20.304  1.00 94.47           N  \\nATOM    846  CA  GLN A 106       6.743  -6.044  19.890  1.00 94.47           C  \\nATOM    847  C   GLN A 106       6.576  -6.468  18.432  1.00 94.47           C  \\nATOM    848  CB  GLN A 106       6.920  -7.238  20.833  1.00 94.47           C  \\nATOM    849  O   GLN A 106       5.506  -6.925  18.029  1.00 94.47           O  \\nATOM    850  CG  GLN A 106       8.252  -7.964  20.603  1.00 94.47           C  \\nATOM    851  CD  GLN A 106       8.509  -9.058  21.633  1.00 94.47           C  \\nATOM    852  NE2 GLN A 106       9.227 -10.094  21.258  1.00 94.47           N  \\nATOM    853  OE1 GLN A 106       8.106  -9.006  22.784  1.00 94.47           O  \\nATOM    854  N   MET A 107       7.638  -6.292  17.646  1.00 93.56           N  \\nATOM    855  CA  MET A 107       7.704  -6.727  16.252  1.00 93.56           C  \\nATOM    856  C   MET A 107       8.435  -8.064  16.138  1.00 93.56           C  \\nATOM    857  CB  MET A 107       8.395  -5.671  15.380  1.00 93.56           C  \\nATOM    858  O   MET A 107       9.413  -8.310  16.845  1.00 93.56           O  \\nATOM    859  CG  MET A 107       7.578  -4.381  15.261  1.00 93.56           C  \\nATOM    860  SD  MET A 107       8.280  -3.169  14.108  1.00 93.56           S  \\nATOM    861  CE  MET A 107       9.740  -2.627  15.039  1.00 93.56           C  \\nATOM    862  N   TYR A 108       7.973  -8.885  15.205  1.00 95.20           N  \\nATOM    863  CA  TYR A 108       8.491 -10.202  14.874  1.00 95.20           C  \\nATOM    864  C   TYR A 108       8.672 -10.292  13.355  1.00 95.20           C  \\nATOM    865  CB  TYR A 108       7.512 -11.272  15.380  1.00 95.20           C  \\nATOM    866  O   TYR A 108       7.773  -9.935  12.591  1.00 95.20           O  \\nATOM    867  CG  TYR A 108       7.264 -11.252  16.878  1.00 95.20           C  \\nATOM    868  CD1 TYR A 108       8.013 -12.092  17.725  1.00 95.20           C  \\nATOM    869  CD2 TYR A 108       6.263 -10.420  17.417  1.00 95.20           C  \\nATOM    870  CE1 TYR A 108       7.751 -12.112  19.108  1.00 95.20           C  \\nATOM    871  CE2 TYR A 108       6.013 -10.423  18.801  1.00 95.20           C  \\nATOM    872  OH  TYR A 108       6.503 -11.261  20.978  1.00 95.20           O  \\nATOM    873  CZ  TYR A 108       6.747 -11.277  19.646  1.00 95.20           C  \\nATOM    874  N   SER A 109       9.839 -10.753  12.908  1.00 92.97           N  \\nATOM    875  CA  SER A 109      10.088 -11.039  11.491  1.00 92.97           C  \\nATOM    876  C   SER A 109       9.464 -12.378  11.130  1.00 92.97           C  \\nATOM    877  CB  SER A 109      11.588 -11.117  11.200  1.00 92.97           C  \\nATOM    878  O   SER A 109       9.809 -13.381  11.746  1.00 92.97           O  \\nATOM    879  OG  SER A 109      12.216  -9.884  11.488  1.00 92.97           O  \\nATOM    880  N   ILE A 110       8.595 -12.406  10.124  1.00 90.72           N  \\nATOM    881  CA  ILE A 110       7.926 -13.642   9.707  1.00 90.72           C  \\nATOM    882  C   ILE A 110       8.910 -14.476   8.868  1.00 90.72           C  \\nATOM    883  CB  ILE A 110       6.621 -13.350   8.941  1.00 90.72           C  \\nATOM    884  O   ILE A 110       9.429 -13.961   7.875  1.00 90.72           O  \\nATOM    885  CG1 ILE A 110       5.714 -12.380   9.735  1.00 90.72           C  \\nATOM    886  CG2 ILE A 110       5.868 -14.669   8.678  1.00 90.72           C  \\nATOM    887  CD1 ILE A 110       4.573 -11.818   8.890  1.00 90.72           C  \\nATOM    888  N   PRO A 111       9.189 -15.737   9.239  1.00 91.62           N  \\nATOM    889  CA  PRO A 111      10.029 -16.629   8.445  1.00 91.62           C  \\nATOM    890  C   PRO A 111       9.454 -16.893   7.042  1.00 91.62           C  \\nATOM    891  CB  PRO A 111      10.124 -17.910   9.275  1.00 91.62           C  \\nATOM    892  O   PRO A 111       8.239 -16.995   6.866  1.00 91.62           O  \\nATOM    893  CG  PRO A 111       9.904 -17.450  10.709  1.00 91.62           C  \\nATOM    894  CD  PRO A 111       8.857 -16.363  10.511  1.00 91.62           C  \\nATOM    895  N   GLU A 112      10.317 -17.031   6.032  1.00 89.42           N  \\nATOM    896  CA  GLU A 112       9.898 -17.234   4.632  1.00 89.42           C  \\nATOM    897  C   GLU A 112       9.109 -18.541   4.432  1.00 89.42           C  \\nATOM    898  CB  GLU A 112      11.150 -17.205   3.737  1.00 89.42           C  \\nATOM    899  O   GLU A 112       8.141 -18.589   3.667  1.00 89.42           O  \\nATOM    900  CG  GLU A 112      10.818 -17.260   2.235  1.00 89.42           C  \\nATOM    901  CD  GLU A 112      12.053 -17.140   1.324  1.00 89.42           C  \\nATOM    902  OE1 GLU A 112      11.845 -17.074   0.090  1.00 89.42           O  \\nATOM    903  OE2 GLU A 112      13.192 -17.104   1.845  1.00 89.42           O  \\nATOM    904  N   ASP A 113       9.471 -19.591   5.166  1.00 91.72           N  \\nATOM    905  CA  ASP A 113       8.769 -20.873   5.193  1.00 91.72           C  \\nATOM    906  C   ASP A 113       7.382 -20.766   5.841  1.00 91.72           C  \\nATOM    907  CB  ASP A 113       9.643 -21.929   5.896  1.00 91.72           C  \\nATOM    908  O   ASP A 113       6.448 -21.422   5.384  1.00 91.72           O  \\nATOM    909  CG  ASP A 113       9.973 -21.619   7.363  1.00 91.72           C  \\nATOM    910  OD1 ASP A 113      10.089 -20.419   7.695  1.00 91.72           O  \\nATOM    911  OD2 ASP A 113      10.148 -22.587   8.132  1.00 91.72           O  \\nATOM    912  N   ALA A 114       7.192 -19.887   6.829  1.00 92.79           N  \\nATOM    913  CA  ALA A 114       5.863 -19.575   7.359  1.00 92.79           C  \\nATOM    914  C   ALA A 114       5.014 -18.782   6.345  1.00 92.79           C  \\nATOM    915  CB  ALA A 114       6.013 -18.838   8.695  1.00 92.79           C  \\nATOM    916  O   ALA A 114       3.817 -19.027   6.213  1.00 92.79           O  \\nATOM    917  N   MET A 115       5.620 -17.867   5.579  1.00 89.91           N  \\nATOM    918  CA  MET A 115       4.913 -17.082   4.551  1.00 89.91           C  \\nATOM    919  C   MET A 115       4.460 -17.925   3.349  1.00 89.91           C  \\nATOM    920  CB  MET A 115       5.811 -15.945   4.039  1.00 89.91           C  \\nATOM    921  O   MET A 115       3.453 -17.602   2.712  1.00 89.91           O  \\nATOM    922  CG  MET A 115       6.109 -14.894   5.111  1.00 89.91           C  \\nATOM    923  SD  MET A 115       7.233 -13.560   4.611  1.00 89.91           S  \\nATOM    924  CE  MET A 115       6.362 -12.886   3.176  1.00 89.91           C  \\nATOM    925  N   THR A 116       5.212 -18.975   3.010  1.00 91.53           N  \\nATOM    926  CA  THR A 116       5.031 -19.771   1.780  1.00 91.53           C  \\nATOM    927  C   THR A 116       4.622 -21.226   2.019  1.00 91.53           C  \\nATOM    928  CB  THR A 116       6.292 -19.721   0.903  1.00 91.53           C  \\nATOM    929  O   THR A 116       4.306 -21.928   1.060  1.00 91.53           O  \\nATOM    930  CG2 THR A 116       6.633 -18.301   0.447  1.00 91.53           C  \\nATOM    931  OG1 THR A 116       7.406 -20.237   1.591  1.00 91.53           O  \\nATOM    932  N   GLY A 117       4.601 -21.679   3.275  1.00 93.72           N  \\nATOM    933  CA  GLY A 117       4.248 -23.038   3.676  1.00 93.72           C  \\nATOM    934  C   GLY A 117       2.739 -23.283   3.742  1.00 93.72           C  \\nATOM    935  O   GLY A 117       2.009 -23.126   2.761  1.00 93.72           O  \\nATOM    936  N   THR A 118       2.253 -23.721   4.902  1.00 96.96           N  \\nATOM    937  CA  THR A 118       0.822 -23.972   5.144  1.00 96.96           C  \\nATOM    938  C   THR A 118       0.217 -22.896   6.039  1.00 96.96           C  \\nATOM    939  CB  THR A 118       0.571 -25.363   5.744  1.00 96.96           C  \\nATOM    940  O   THR A 118       0.921 -22.227   6.794  1.00 96.96           O  \\nATOM    941  CG2 THR A 118       1.183 -26.497   4.923  1.00 96.96           C  \\nATOM    942  OG1 THR A 118       1.105 -25.439   7.041  1.00 96.96           O  \\nATOM    943  N   ALA A 119      -1.107 -22.748   5.988  1.00 96.77           N  \\nATOM    944  CA  ALA A 119      -1.842 -21.903   6.919  1.00 96.77           C  \\nATOM    945  C   ALA A 119      -1.529 -22.282   8.373  1.00 96.77           C  \\nATOM    946  CB  ALA A 119      -3.337 -22.044   6.619  1.00 96.77           C  \\nATOM    947  O   ALA A 119      -1.260 -21.406   9.186  1.00 96.77           O  \\nATOM    948  N   GLU A 120      -1.486 -23.580   8.690  1.00 97.51           N  \\nATOM    949  CA  GLU A 120      -1.136 -24.060  10.030  1.00 97.51           C  \\nATOM    950  C   GLU A 120       0.232 -23.533  10.483  1.00 97.51           C  \\nATOM    951  CB  GLU A 120      -1.211 -25.594  10.061  1.00 97.51           C  \\nATOM    952  O   GLU A 120       0.312 -22.933  11.549  1.00 97.51           O  \\nATOM    953  CG  GLU A 120      -0.963 -26.155  11.467  1.00 97.51           C  \\nATOM    954  CD  GLU A 120      -1.308 -27.648  11.542  1.00 97.51           C  \\nATOM    955  OE1 GLU A 120      -0.373 -28.478  11.591  1.00 97.51           O  \\nATOM    956  OE2 GLU A 120      -2.524 -27.956  11.528  1.00 97.51           O  \\nATOM    957  N   MET A 121       1.271 -23.635   9.643  1.00 96.57           N  \\nATOM    958  CA  MET A 121       2.605 -23.103   9.962  1.00 96.57           C  \\nATOM    959  C   MET A 121       2.583 -21.595  10.248  1.00 96.57           C  \\nATOM    960  CB  MET A 121       3.578 -23.374   8.806  1.00 96.57           C  \\nATOM    961  O   MET A 121       3.187 -21.142  11.221  1.00 96.57           O  \\nATOM    962  CG  MET A 121       3.945 -24.853   8.660  1.00 96.57           C  \\nATOM    963  SD  MET A 121       4.807 -25.246   7.108  1.00 96.57           S  \\nATOM    964  CE  MET A 121       6.349 -24.311   7.349  1.00 96.57           C  \\nATOM    965  N   LEU A 122       1.876 -20.813   9.425  1.00 96.86           N  \\nATOM    966  CA  LEU A 122       1.774 -19.363   9.602  1.00 96.86           C  \\nATOM    967  C   LEU A 122       1.052 -18.994  10.905  1.00 96.86           C  \\nATOM    968  CB  LEU A 122       1.067 -18.753   8.377  1.00 96.86           C  \\nATOM    969  O   LEU A 122       1.539 -18.163  11.672  1.00 96.86           O  \\nATOM    970  CG  LEU A 122       0.884 -17.224   8.447  1.00 96.86           C  \\nATOM    971  CD1 LEU A 122       2.209 -16.465   8.572  1.00 96.86           C  \\nATOM    972  CD2 LEU A 122       0.167 -16.738   7.187  1.00 96.86           C  \\nATOM    973  N   PHE A 123      -0.111 -19.595  11.164  1.00 97.37           N  \\nATOM    974  CA  PHE A 123      -0.923 -19.254  12.333  1.00 97.37           C  \\nATOM    975  C   PHE A 123      -0.349 -19.825  13.639  1.00 97.37           C  \\nATOM    976  CB  PHE A 123      -2.394 -19.627  12.094  1.00 97.37           C  \\nATOM    977  O   PHE A 123      -0.483 -19.184  14.683  1.00 97.37           O  \\nATOM    978  CG  PHE A 123      -3.096 -18.705  11.108  1.00 97.37           C  \\nATOM    979  CD1 PHE A 123      -3.516 -17.425  11.517  1.00 97.37           C  \\nATOM    980  CD2 PHE A 123      -3.329 -19.105   9.780  1.00 97.37           C  \\nATOM    981  CE1 PHE A 123      -4.135 -16.556  10.599  1.00 97.37           C  \\nATOM    982  CE2 PHE A 123      -3.905 -18.226   8.850  1.00 97.37           C  \\nATOM    983  CZ  PHE A 123      -4.313 -16.950   9.261  1.00 97.37           C  \\nATOM    984  N   ASP A 124       0.362 -20.954  13.598  1.00 97.60           N  \\nATOM    985  CA  ASP A 124       1.089 -21.490  14.755  1.00 97.60           C  \\nATOM    986  C   ASP A 124       2.281 -20.594  15.134  1.00 97.60           C  \\nATOM    987  CB  ASP A 124       1.547 -22.934  14.488  1.00 97.60           C  \\nATOM    988  O   ASP A 124       2.507 -20.352  16.328  1.00 97.60           O  \\nATOM    989  CG  ASP A 124       0.421 -23.981  14.569  1.00 97.60           C  \\nATOM    990  OD1 ASP A 124      -0.773 -23.623  14.738  1.00 97.60           O  \\nATOM    991  OD2 ASP A 124       0.747 -25.184  14.551  1.00 97.60           O  \\nATOM    992  N   TYR A 125       2.981 -20.032  14.137  1.00 96.76           N  \\nATOM    993  CA  TYR A 125       4.011 -19.008  14.343  1.00 96.76           C  \\nATOM    994  C   TYR A 125       3.419 -17.724  14.943  1.00 96.76           C  \\nATOM    995  CB  TYR A 125       4.731 -18.714  13.017  1.00 96.76           C  \\nATOM    996  O   TYR A 125       3.923 -17.213  15.942  1.00 96.76           O  \\nATOM    997  CG  TYR A 125       5.762 -17.611  13.144  1.00 96.76           C  \\nATOM    998  CD1 TYR A 125       5.441 -16.288  12.774  1.00 96.76           C  \\nATOM    999  CD2 TYR A 125       7.012 -17.900  13.720  1.00 96.76           C  \\nATOM   1000  CE1 TYR A 125       6.360 -15.250  13.015  1.00 96.76           C  \\nATOM   1001  CE2 TYR A 125       7.939 -16.869  13.950  1.00 96.76           C  \\nATOM   1002  OH  TYR A 125       8.469 -14.538  13.899  1.00 96.76           O  \\nATOM   1003  CZ  TYR A 125       7.600 -15.540  13.621  1.00 96.76           C  \\nATOM   1004  N   ILE A 126       2.296 -17.234  14.404  1.00 96.63           N  \\nATOM   1005  CA  ILE A 126       1.570 -16.081  14.968  1.00 96.63           C  \\nATOM   1006  C   ILE A 126       1.200 -16.339  16.437  1.00 96.63           C  \\nATOM   1007  CB  ILE A 126       0.329 -15.767  14.099  1.00 96.63           C  \\nATOM   1008  O   ILE A 126       1.434 -15.488  17.297  1.00 96.63           O  \\nATOM   1009  CG1 ILE A 126       0.767 -15.108  12.772  1.00 96.63           C  \\nATOM   1010  CG2 ILE A 126      -0.685 -14.881  14.843  1.00 96.63           C  \\nATOM   1011  CD1 ILE A 126      -0.345 -15.053  11.714  1.00 96.63           C  \\nATOM   1012  N   SER A 127       0.672 -17.527  16.746  1.00 96.46           N  \\nATOM   1013  CA  SER A 127       0.353 -17.945  18.115  1.00 96.46           C  \\nATOM   1014  C   SER A 127       1.592 -17.963  19.025  1.00 96.46           C  \\nATOM   1015  CB  SER A 127      -0.320 -19.321  18.066  1.00 96.46           C  \\nATOM   1016  O   SER A 127       1.500 -17.594  20.197  1.00 96.46           O  \\nATOM   1017  OG  SER A 127      -0.643 -19.767  19.368  1.00 96.46           O  \\nATOM   1018  N   GLU A 128       2.765 -18.328  18.497  1.00 96.97           N  \\nATOM   1019  CA  GLU A 128       4.042 -18.264  19.223  1.00 96.97           C  \\nATOM   1020  C   GLU A 128       4.414 -16.844  19.618  1.00 96.97           C  \\nATOM   1021  CB  GLU A 128       5.185 -18.847  18.375  1.00 96.97           C  \\nATOM   1022  O   GLU A 128       4.709 -16.579  20.783  1.00 96.97           O  \\nATOM   1023  CG  GLU A 128       6.360 -19.253  19.273  1.00 96.97           C  \\nATOM   1024  CD  GLU A 128       7.435 -20.027  18.506  1.00 96.97           C  \\nATOM   1025  OE1 GLU A 128       8.624 -19.867  18.858  1.00 96.97           O  \\nATOM   1026  OE2 GLU A 128       7.040 -20.847  17.650  1.00 96.97           O  \\nATOM   1027  N   CYS A 129       4.354 -15.923  18.658  1.00 96.98           N  \\nATOM   1028  CA  CYS A 129       4.657 -14.518  18.886  1.00 96.98           C  \\nATOM   1029  C   CYS A 129       3.718 -13.908  19.933  1.00 96.98           C  \\nATOM   1030  CB  CYS A 129       4.526 -13.785  17.552  1.00 96.98           C  \\nATOM   1031  O   CYS A 129       4.158 -13.163  20.807  1.00 96.98           O  \\nATOM   1032  SG  CYS A 129       5.733 -14.396  16.350  1.00 96.98           S  \\nATOM   1033  N   ILE A 130       2.431 -14.260  19.885  1.00 96.16           N  \\nATOM   1034  CA  ILE A 130       1.457 -13.840  20.895  1.00 96.16           C  \\nATOM   1035  C   ILE A 130       1.848 -14.375  22.278  1.00 96.16           C  \\nATOM   1036  CB  ILE A 130       0.046 -14.301  20.492  1.00 96.16           C  \\nATOM   1037  O   ILE A 130       1.899 -13.603  23.235  1.00 96.16           O  \\nATOM   1038  CG1 ILE A 130      -0.430 -13.587  19.210  1.00 96.16           C  \\nATOM   1039  CG2 ILE A 130      -0.940 -14.026  21.632  1.00 96.16           C  \\nATOM   1040  CD1 ILE A 130      -1.670 -14.239  18.585  1.00 96.16           C  \\nATOM   1041  N   SER A 131       2.147 -15.673  22.386  1.00 96.18           N  \\nATOM   1042  CA  SER A 131       2.564 -16.310  23.643  1.00 96.18           C  \\nATOM   1043  C   SER A 131       3.792 -15.620  24.251  1.00 96.18           C  \\nATOM   1044  CB  SER A 131       2.868 -17.793  23.400  1.00 96.18           C  \\nATOM   1045  O   SER A 131       3.763 -15.239  25.424  1.00 96.18           O  \\nATOM   1046  OG  SER A 131       3.160 -18.439  24.622  1.00 96.18           O  \\nATOM   1047  N   ASP A 132       4.830 -15.381  23.441  1.00 96.99           N  \\nATOM   1048  CA  ASP A 132       6.058 -14.683  23.844  1.00 96.99           C  \\nATOM   1049  C   ASP A 132       5.769 -13.265  24.360  1.00 96.99           C  \\nATOM   1050  CB  ASP A 132       7.029 -14.648  22.648  1.00 96.99           C  \\nATOM   1051  O   ASP A 132       6.261 -12.866  25.421  1.00 96.99           O  \\nATOM   1052  CG  ASP A 132       8.243 -13.737  22.881  1.00 96.99           C  \\nATOM   1053  OD1 ASP A 132       9.141 -14.044  23.691  1.00 96.99           O  \\nATOM   1054  OD2 ASP A 132       8.328 -12.651  22.254  1.00 96.99           O  \\nATOM   1055  N   PHE A 133       4.926 -12.506  23.653  1.00 96.58           N  \\nATOM   1056  CA  PHE A 133       4.532 -11.167  24.085  1.00 96.58           C  \\nATOM   1057  C   PHE A 133       3.782 -11.198  25.423  1.00 96.58           C  \\nATOM   1058  CB  PHE A 133       3.666 -10.507  23.008  1.00 96.58           C  \\nATOM   1059  O   PHE A 133       4.070 -10.393  26.318  1.00 96.58           O  \\nATOM   1060  CG  PHE A 133       3.266  -9.090  23.367  1.00 96.58           C  \\nATOM   1061  CD1 PHE A 133       2.033  -8.829  23.992  1.00 96.58           C  \\nATOM   1062  CD2 PHE A 133       4.147  -8.032  23.097  1.00 96.58           C  \\nATOM   1063  CE1 PHE A 133       1.680  -7.509  24.325  1.00 96.58           C  \\nATOM   1064  CE2 PHE A 133       3.787  -6.709  23.409  1.00 96.58           C  \\nATOM   1065  CZ  PHE A 133       2.552  -6.448  24.025  1.00 96.58           C  \\nATOM   1066  N   LEU A 134       2.827 -12.122  25.580  1.00 95.45           N  \\nATOM   1067  CA  LEU A 134       2.046 -12.272  26.807  1.00 95.45           C  \\nATOM   1068  C   LEU A 134       2.920 -12.694  27.994  1.00 95.45           C  \\nATOM   1069  CB  LEU A 134       0.905 -13.283  26.592  1.00 95.45           C  \\nATOM   1070  O   LEU A 134       2.705 -12.181  29.093  1.00 95.45           O  \\nATOM   1071  CG  LEU A 134      -0.225 -12.839  25.646  1.00 95.45           C  \\nATOM   1072  CD1 LEU A 134      -1.221 -13.989  25.507  1.00 95.45           C  \\nATOM   1073  CD2 LEU A 134      -0.981 -11.611  26.158  1.00 95.45           C  \\nATOM   1074  N   ASP A 135       3.913 -13.564  27.795  1.00 94.75           N  \\nATOM   1075  CA  ASP A 135       4.872 -13.958  28.837  1.00 94.75           C  \\nATOM   1076  C   ASP A 135       5.711 -12.773  29.313  1.00 94.75           C  \\nATOM   1077  CB  ASP A 135       5.812 -15.067  28.327  1.00 94.75           C  \\nATOM   1078  O   ASP A 135       5.769 -12.487  30.512  1.00 94.75           O  \\nATOM   1079  CG  ASP A 135       5.280 -16.476  28.570  1.00 94.75           C  \\nATOM   1080  OD1 ASP A 135       4.409 -16.649  29.451  1.00 94.75           O  \\nATOM   1081  OD2 ASP A 135       5.734 -17.419  27.890  1.00 94.75           O  \\nATOM   1082  N   LYS A 136       6.301 -12.023  28.374  1.00 95.77           N  \\nATOM   1083  CA  LYS A 136       7.128 -10.841  28.676  1.00 95.77           C  \\nATOM   1084  C   LYS A 136       6.385  -9.780  29.482  1.00 95.77           C  \\nATOM   1085  CB  LYS A 136       7.628 -10.244  27.357  1.00 95.77           C  \\nATOM   1086  O   LYS A 136       6.996  -9.058  30.268  1.00 95.77           O  \\nATOM   1087  CG  LYS A 136       8.795 -11.069  26.813  1.00 95.77           C  \\nATOM   1088  CD  LYS A 136       9.121 -10.660  25.380  1.00 95.77           C  \\nATOM   1089  CE  LYS A 136      10.383 -11.399  24.946  1.00 95.77           C  \\nATOM   1090  NZ  LYS A 136      10.460 -11.481  23.480  1.00 95.77           N  \\nATOM   1091  N   HIS A 137       5.070  -9.704  29.309  1.00 93.86           N  \\nATOM   1092  CA  HIS A 137       4.209  -8.747  29.994  1.00 93.86           C  \\nATOM   1093  C   HIS A 137       3.412  -9.356  31.157  1.00 93.86           C  \\nATOM   1094  CB  HIS A 137       3.322  -8.073  28.948  1.00 93.86           C  \\nATOM   1095  O   HIS A 137       2.634  -8.638  31.785  1.00 93.86           O  \\nATOM   1096  CG  HIS A 137       4.116  -7.244  27.972  1.00 93.86           C  \\nATOM   1097  CD2 HIS A 137       4.439  -5.924  28.100  1.00 93.86           C  \\nATOM   1098  ND1 HIS A 137       4.693  -7.688  26.809  1.00 93.86           N  \\nATOM   1099  CE1 HIS A 137       5.351  -6.660  26.250  1.00 93.86           C  \\nATOM   1100  NE2 HIS A 137       5.219  -5.550  27.004  1.00 93.86           N  \\nATOM   1101  N   GLN A 138       3.608 -10.644  31.467  1.00 93.11           N  \\nATOM   1102  CA  GLN A 138       2.908 -11.377  32.529  1.00 93.11           C  \\nATOM   1103  C   GLN A 138       1.377 -11.333  32.374  1.00 93.11           C  \\nATOM   1104  CB  GLN A 138       3.384 -10.916  33.920  1.00 93.11           C  \\nATOM   1105  O   GLN A 138       0.643 -11.119  33.337  1.00 93.11           O  \\nATOM   1106  CG  GLN A 138       4.904 -11.018  34.104  1.00 93.11           C  \\nATOM   1107  CD  GLN A 138       5.374 -10.412  35.420  1.00 93.11           C  \\nATOM   1108  NE2 GLN A 138       6.639 -10.069  35.521  1.00 93.11           N  \\nATOM   1109  OE1 GLN A 138       4.641 -10.223  36.377  1.00 93.11           O  \\nATOM   1110  N   MET A 139       0.880 -11.518  31.149  1.00 91.67           N  \\nATOM   1111  CA  MET A 139      -0.540 -11.371  30.803  1.00 91.67           C  \\nATOM   1112  C   MET A 139      -1.224 -12.661  30.339  1.00 91.67           C  \\nATOM   1113  CB  MET A 139      -0.733 -10.254  29.766  1.00 91.67           C  \\nATOM   1114  O   MET A 139      -2.409 -12.607  30.039  1.00 91.67           O  \\nATOM   1115  CG  MET A 139      -0.239  -8.898  30.271  1.00 91.67           C  \\nATOM   1116  SD  MET A 139      -0.804  -7.467  29.317  1.00 91.67           S  \\nATOM   1117  CE  MET A 139      -0.148  -7.887  27.674  1.00 91.67           C  \\nATOM   1118  N   LYS A 140      -0.552 -13.822  30.325  1.00 90.85           N  \\nATOM   1119  CA  LYS A 140      -1.161 -15.094  29.866  1.00 90.85           C  \\nATOM   1120  C   LYS A 140      -2.451 -15.496  30.588  1.00 90.85           C  \\nATOM   1121  CB  LYS A 140      -0.158 -16.250  29.987  1.00 90.85           C  \\nATOM   1122  O   LYS A 140      -3.299 -16.161  30.011  1.00 90.85           O  \\nATOM   1123  CG  LYS A 140       0.869 -16.224  28.855  1.00 90.85           C  \\nATOM   1124  CD  LYS A 140       1.590 -17.570  28.759  1.00 90.85           C  \\nATOM   1125  CE  LYS A 140       2.455 -17.531  27.503  1.00 90.85           C  \\nATOM   1126  NZ  LYS A 140       3.405 -18.656  27.438  1.00 90.85           N  \\nATOM   1127  N   HIS A 141      -2.607 -15.081  31.843  1.00 89.02           N  \\nATOM   1128  CA  HIS A 141      -3.799 -15.353  32.650  1.00 89.02           C  \\nATOM   1129  C   HIS A 141      -4.969 -14.394  32.360  1.00 89.02           C  \\nATOM   1130  CB  HIS A 141      -3.401 -15.313  34.133  1.00 89.02           C  \\nATOM   1131  O   HIS A 141      -6.046 -14.558  32.931  1.00 89.02           O  \\nATOM   1132  CG  HIS A 141      -2.929 -13.953  34.590  1.00 89.02           C  \\nATOM   1133  CD2 HIS A 141      -3.707 -12.958  35.121  1.00 89.02           C  \\nATOM   1134  ND1 HIS A 141      -1.640 -13.470  34.533  1.00 89.02           N  \\nATOM   1135  CE1 HIS A 141      -1.644 -12.221  35.028  1.00 89.02           C  \\nATOM   1136  NE2 HIS A 141      -2.884 -11.857  35.387  1.00 89.02           N  \\nATOM   1137  N   LYS A 142      -4.764 -13.362  31.531  1.00 88.35           N  \\nATOM   1138  CA  LYS A 142      -5.791 -12.380  31.178  1.00 88.35           C  \\nATOM   1139  C   LYS A 142      -6.439 -12.750  29.852  1.00 88.35           C  \\nATOM   1140  CB  LYS A 142      -5.203 -10.967  31.080  1.00 88.35           C  \\nATOM   1141  O   LYS A 142      -5.751 -12.922  28.852  1.00 88.35           O  \\nATOM   1142  CG  LYS A 142      -4.638 -10.457  32.410  1.00 88.35           C  \\nATOM   1143  CD  LYS A 142      -4.281  -8.977  32.261  1.00 88.35           C  \\nATOM   1144  CE  LYS A 142      -3.834  -8.400  33.602  1.00 88.35           C  \\nATOM   1145  NZ  LYS A 142      -3.636  -6.936  33.485  1.00 88.35           N  \\nATOM   1146  N   LYS A 143      -7.769 -12.754  29.831  1.00 88.59           N  \\nATOM   1147  CA  LYS A 143      -8.562 -12.848  28.605  1.00 88.59           C  \\nATOM   1148  C   LYS A 143      -8.906 -11.439  28.128  1.00 88.59           C  \\nATOM   1149  CB  LYS A 143      -9.781 -13.732  28.888  1.00 88.59           C  \\nATOM   1150  O   LYS A 143      -9.872 -10.848  28.602  1.00 88.59           O  \\nATOM   1151  CG  LYS A 143     -10.524 -14.105  27.600  1.00 88.59           C  \\nATOM   1152  CD  LYS A 143     -11.547 -15.199  27.917  1.00 88.59           C  \\nATOM   1153  CE  LYS A 143     -12.169 -15.751  26.636  1.00 88.59           C  \\nATOM   1154  NZ  LYS A 143     -12.660 -17.130  26.866  1.00 88.59           N  \\nATOM   1155  N   LEU A 144      -8.053 -10.874  27.275  1.00 90.45           N  \\nATOM   1156  CA  LEU A 144      -8.263  -9.543  26.696  1.00 90.45           C  \\nATOM   1157  C   LEU A 144      -9.009  -9.651  25.356  1.00 90.45           C  \\nATOM   1158  CB  LEU A 144      -6.925  -8.802  26.519  1.00 90.45           C  \\nATOM   1159  O   LEU A 144      -8.735 -10.594  24.604  1.00 90.45           O  \\nATOM   1160  CG  LEU A 144      -6.157  -8.521  27.823  1.00 90.45           C  \\nATOM   1161  CD1 LEU A 144      -4.837  -7.818  27.500  1.00 90.45           C  \\nATOM   1162  CD2 LEU A 144      -6.939  -7.637  28.798  1.00 90.45           C  \\nATOM   1163  N   PRO A 145      -9.888  -8.688  25.023  1.00 93.29           N  \\nATOM   1164  CA  PRO A 145     -10.429  -8.575  23.677  1.00 93.29           C  \\nATOM   1165  C   PRO A 145      -9.300  -8.293  22.680  1.00 93.29           C  \\nATOM   1166  CB  PRO A 145     -11.464  -7.447  23.713  1.00 93.29           C  \\nATOM   1167  O   PRO A 145      -8.414  -7.469  22.936  1.00 93.29           O  \\nATOM   1168  CG  PRO A 145     -11.717  -7.194  25.198  1.00 93.29           C  \\nATOM   1169  CD  PRO A 145     -10.413  -7.621  25.864  1.00 93.29           C  \\nATOM   1170  N   LEU A 146      -9.336  -8.991  21.549  1.00 94.81           N  \\nATOM   1171  CA  LEU A 146      -8.313  -8.976  20.515  1.00 94.81           C  \\nATOM   1172  C   LEU A 146      -8.862  -8.355  19.229  1.00 94.81           C  \\nATOM   1173  CB  LEU A 146      -7.815 -10.415  20.290  1.00 94.81           C  \\nATOM   1174  O   LEU A 146      -9.843  -8.845  18.670  1.00 94.81           O  \\nATOM   1175  CG  LEU A 146      -6.631 -10.525  19.312  1.00 94.81           C  \\nATOM   1176  CD1 LEU A 146      -5.394  -9.971  20.000  1.00 94.81           C  \\nATOM   1177  CD2 LEU A 146      -6.361 -11.979  18.916  1.00 94.81           C  \\nATOM   1178  N   GLY A 147      -8.204  -7.301  18.750  1.00 95.81           N  \\nATOM   1179  CA  GLY A 147      -8.372  -6.796  17.387  1.00 95.81           C  \\nATOM   1180  C   GLY A 147      -7.305  -7.369  16.462  1.00 95.81           C  \\nATOM   1181  O   GLY A 147      -6.125  -7.355  16.805  1.00 95.81           O  \\nATOM   1182  N   PHE A 148      -7.686  -7.860  15.290  1.00 96.33           N  \\nATOM   1183  CA  PHE A 148      -6.737  -8.404  14.323  1.00 96.33           C  \\nATOM   1184  C   PHE A 148      -6.710  -7.569  13.043  1.00 96.33           C  \\nATOM   1185  CB  PHE A 148      -7.054  -9.884  14.067  1.00 96.33           C  \\nATOM   1186  O   PHE A 148      -7.629  -7.628  12.233  1.00 96.33           O  \\nATOM   1187  CG  PHE A 148      -6.043 -10.653  13.228  1.00 96.33           C  \\nATOM   1188  CD1 PHE A 148      -6.383 -11.938  12.766  1.00 96.33           C  \\nATOM   1189  CD2 PHE A 148      -4.762 -10.139  12.929  1.00 96.33           C  \\nATOM   1190  CE1 PHE A 148      -5.450 -12.704  12.045  1.00 96.33           C  \\nATOM   1191  CE2 PHE A 148      -3.834 -10.901  12.207  1.00 96.33           C  \\nATOM   1192  CZ  PHE A 148      -4.172 -12.191  11.772  1.00 96.33           C  \\nATOM   1193  N   THR A 149      -5.630  -6.821  12.837  1.00 96.08           N  \\nATOM   1194  CA  THR A 149      -5.325  -6.211  11.546  1.00 96.08           C  \\nATOM   1195  C   THR A 149      -4.693  -7.240  10.617  1.00 96.08           C  \\nATOM   1196  CB  THR A 149      -4.450  -4.965  11.675  1.00 96.08           C  \\nATOM   1197  O   THR A 149      -3.586  -7.728  10.859  1.00 96.08           O  \\nATOM   1198  CG2 THR A 149      -4.217  -4.332  10.309  1.00 96.08           C  \\nATOM   1199  OG1 THR A 149      -5.159  -4.026  12.435  1.00 96.08           O  \\nATOM   1200  N   PHE A 150      -5.408  -7.563   9.545  1.00 95.11           N  \\nATOM   1201  CA  PHE A 150      -4.999  -8.516   8.527  1.00 95.11           C  \\nATOM   1202  C   PHE A 150      -4.970  -7.819   7.163  1.00 95.11           C  \\nATOM   1203  CB  PHE A 150      -5.940  -9.721   8.593  1.00 95.11           C  \\nATOM   1204  O   PHE A 150      -5.999  -7.538   6.554  1.00 95.11           O  \\nATOM   1205  CG  PHE A 150      -5.504 -10.878   7.726  1.00 95.11           C  \\nATOM   1206  CD1 PHE A 150      -6.120 -11.085   6.485  1.00 95.11           C  \\nATOM   1207  CD2 PHE A 150      -4.518 -11.776   8.175  1.00 95.11           C  \\nATOM   1208  CE1 PHE A 150      -5.802 -12.219   5.726  1.00 95.11           C  \\nATOM   1209  CE2 PHE A 150      -4.177 -12.898   7.397  1.00 95.11           C  \\nATOM   1210  CZ  PHE A 150      -4.821 -13.121   6.169  1.00 95.11           C  \\nATOM   1211  N   SER A 151      -3.763  -7.510   6.690  1.00 91.12           N  \\nATOM   1212  CA  SER A 151      -3.502  -6.617   5.552  1.00 91.12           C  \\nATOM   1213  C   SER A 151      -3.790  -7.205   4.159  1.00 91.12           C  \\nATOM   1214  CB  SER A 151      -2.034  -6.189   5.621  1.00 91.12           C  \\nATOM   1215  O   SER A 151      -3.229  -6.718   3.172  1.00 91.12           O  \\nATOM   1216  OG  SER A 151      -1.750  -5.412   6.754  1.00 91.12           O  \\nATOM   1217  N   PHE A 152      -4.583  -8.269   4.051  1.00 92.53           N  \\nATOM   1218  CA  PHE A 152      -4.833  -8.985   2.794  1.00 92.53           C  \\nATOM   1219  C   PHE A 152      -6.312  -8.903   2.393  1.00 92.53           C  \\nATOM   1220  CB  PHE A 152      -4.361 -10.441   2.913  1.00 92.53           C  \\nATOM   1221  O   PHE A 152      -7.150  -8.660   3.266  1.00 92.53           O  \\nATOM   1222  CG  PHE A 152      -2.912 -10.590   3.322  1.00 92.53           C  \\nATOM   1223  CD1 PHE A 152      -1.904 -10.635   2.343  1.00 92.53           C  \\nATOM   1224  CD2 PHE A 152      -2.572 -10.648   4.686  1.00 92.53           C  \\nATOM   1225  CE1 PHE A 152      -0.559 -10.757   2.731  1.00 92.53           C  \\nATOM   1226  CE2 PHE A 152      -1.226 -10.744   5.072  1.00 92.53           C  \\nATOM   1227  CZ  PHE A 152      -0.223 -10.803   4.094  1.00 92.53           C  \\nATOM   1228  N   PRO A 153      -6.644  -9.130   1.107  1.00 93.17           N  \\nATOM   1229  CA  PRO A 153      -8.023  -9.109   0.630  1.00 93.17           C  \\nATOM   1230  C   PRO A 153      -8.895 -10.139   1.356  1.00 93.17           C  \\nATOM   1231  CB  PRO A 153      -7.957  -9.383  -0.878  1.00 93.17           C  \\nATOM   1232  O   PRO A 153      -8.706 -11.352   1.225  1.00 93.17           O  \\nATOM   1233  CG  PRO A 153      -6.537  -8.994  -1.269  1.00 93.17           C  \\nATOM   1234  CD  PRO A 153      -5.728  -9.301  -0.015  1.00 93.17           C  \\nATOM   1235  N   VAL A 154      -9.874  -9.656   2.118  1.00 95.00           N  \\nATOM   1236  CA  VAL A 154     -10.784 -10.488   2.909  1.00 95.00           C  \\nATOM   1237  C   VAL A 154     -12.225 -10.116   2.608  1.00 95.00           C  \\nATOM   1238  CB  VAL A 154     -10.484 -10.364   4.413  1.00 95.00           C  \\nATOM   1239  O   VAL A 154     -12.623  -8.960   2.740  1.00 95.00           O  \\nATOM   1240  CG1 VAL A 154     -11.575 -11.009   5.267  1.00 95.00           C  \\nATOM   1241  CG2 VAL A 154      -9.184 -11.090   4.775  1.00 95.00           C  \\nATOM   1242  N   ARG A 155     -13.038 -11.122   2.279  1.00 94.21           N  \\nATOM   1243  CA  ARG A 155     -14.493 -10.980   2.264  1.00 94.21           C  \\nATOM   1244  C   ARG A 155     -15.014 -11.188   3.679  1.00 94.21           C  \\nATOM   1245  CB  ARG A 155     -15.103 -11.949   1.248  1.00 94.21           C  \\nATOM   1246  O   ARG A 155     -14.997 -12.311   4.189  1.00 94.21           O  \\nATOM   1247  CG  ARG A 155     -16.630 -11.800   1.156  1.00 94.21           C  \\nATOM   1248  CD  ARG A 155     -17.236 -12.737   0.100  1.00 94.21           C  \\nATOM   1249  NE  ARG A 155     -17.040 -14.169   0.425  1.00 94.21           N  \\nATOM   1250  NH1 ARG A 155     -18.614 -14.358   2.106  1.00 94.21           N  \\nATOM   1251  NH2 ARG A 155     -17.379 -16.089   1.640  1.00 94.21           N  \\nATOM   1252  CZ  ARG A 155     -17.673 -14.854   1.366  1.00 94.21           C  \\nATOM   1253  N   HIS A 156     -15.466 -10.110   4.305  1.00 92.55           N  \\nATOM   1254  CA  HIS A 156     -16.102 -10.180   5.612  1.00 92.55           C  \\nATOM   1255  C   HIS A 156     -17.515 -10.758   5.501  1.00 92.55           C  \\nATOM   1256  CB  HIS A 156     -16.083  -8.808   6.286  1.00 92.55           C  \\nATOM   1257  O   HIS A 156     -18.271 -10.441   4.584  1.00 92.55           O  \\nATOM   1258  CG  HIS A 156     -14.714  -8.445   6.791  1.00 92.55           C  \\nATOM   1259  CD2 HIS A 156     -13.663  -7.940   6.069  1.00 92.55           C  \\nATOM   1260  ND1 HIS A 156     -14.278  -8.634   8.079  1.00 92.55           N  \\nATOM   1261  CE1 HIS A 156     -12.992  -8.252   8.134  1.00 92.55           C  \\nATOM   1262  NE2 HIS A 156     -12.565  -7.834   6.931  1.00 92.55           N  \\nATOM   1263  N   GLU A 157     -17.849 -11.623   6.449  1.00 89.34           N  \\nATOM   1264  CA  GLU A 157     -19.216 -12.085   6.709  1.00 89.34           C  \\nATOM   1265  C   GLU A 157     -19.757 -11.481   8.011  1.00 89.34           C  \\nATOM   1266  CB  GLU A 157     -19.236 -13.621   6.764  1.00 89.34           C  \\nATOM   1267  O   GLU A 157     -20.966 -11.379   8.174  1.00 89.34           O  \\nATOM   1268  CG  GLU A 157     -18.929 -14.235   5.390  1.00 89.34           C  \\nATOM   1269  CD  GLU A 157     -18.975 -15.768   5.344  1.00 89.34           C  \\nATOM   1270  OE1 GLU A 157     -18.757 -16.292   4.222  1.00 89.34           O  \\nATOM   1271  OE2 GLU A 157     -19.204 -16.421   6.392  1.00 89.34           O  \\nATOM   1272  N   ASP A 158     -18.858 -11.077   8.913  1.00 88.25           N  \\nATOM   1273  CA  ASP A 158     -19.132 -10.303  10.123  1.00 88.25           C  \\nATOM   1274  C   ASP A 158     -17.843  -9.559  10.547  1.00 88.25           C  \\nATOM   1275  CB  ASP A 158     -19.638 -11.246  11.236  1.00 88.25           C  \\nATOM   1276  O   ASP A 158     -16.779  -9.727   9.935  1.00 88.25           O  \\nATOM   1277  CG  ASP A 158     -20.550 -10.549  12.258  1.00 88.25           C  \\nATOM   1278  OD1 ASP A 158     -20.465  -9.303  12.380  1.00 88.25           O  \\nATOM   1279  OD2 ASP A 158     -21.333 -11.271  12.912  1.00 88.25           O  \\nATOM   1280  N   ILE A 159     -17.902  -8.761  11.615  1.00 88.43           N  \\nATOM   1281  CA  ILE A 159     -16.758  -8.007  12.144  1.00 88.43           C  \\nATOM   1282  C   ILE A 159     -15.617  -8.913  12.633  1.00 88.43           C  \\nATOM   1283  CB  ILE A 159     -17.232  -7.020  13.233  1.00 88.43           C  \\nATOM   1284  O   ILE A 159     -14.456  -8.522  12.552  1.00 88.43           O  \\nATOM   1285  CG1 ILE A 159     -16.140  -5.964  13.514  1.00 88.43           C  \\nATOM   1286  CG2 ILE A 159     -17.670  -7.741  14.523  1.00 88.43           C  \\nATOM   1287  CD1 ILE A 159     -16.657  -4.740  14.279  1.00 88.43           C  \\nATOM   1288  N   ASP A 160     -15.907 -10.134  13.093  1.00 89.61           N  \\nATOM   1289  CA  ASP A 160     -14.925 -11.126  13.557  1.00 89.61           C  \\nATOM   1290  C   ASP A 160     -14.847 -12.372  12.649  1.00 89.61           C  \\nATOM   1291  CB  ASP A 160     -15.194 -11.490  15.030  1.00 89.61           C  \\nATOM   1292  O   ASP A 160     -14.254 -13.391  13.017  1.00 89.61           O  \\nATOM   1293  CG  ASP A 160     -16.297 -12.545  15.194  1.00 89.61           C  \\nATOM   1294  OD1 ASP A 160     -17.256 -12.506  14.393  1.00 89.61           O  \\nATOM   1295  OD2 ASP A 160     -16.128 -13.445  16.060  1.00 89.61           O  \\nATOM   1296  N   LYS A 161     -15.427 -12.305  11.444  1.00 92.80           N  \\nATOM   1297  CA  LYS A 161     -15.452 -13.417  10.489  1.00 92.80           C  \\nATOM   1298  C   LYS A 161     -15.117 -12.928   9.092  1.00 92.80           C  \\nATOM   1299  CB  LYS A 161     -16.830 -14.088  10.545  1.00 92.80           C  \\nATOM   1300  O   LYS A 161     -15.904 -12.228   8.459  1.00 92.80           O  \\nATOM   1301  CG  LYS A 161     -16.839 -15.405   9.759  1.00 92.80           C  \\nATOM   1302  CD  LYS A 161     -18.239 -16.017   9.781  1.00 92.80           C  \\nATOM   1303  CE  LYS A 161     -18.228 -17.384   9.094  1.00 92.80           C  \\nATOM   1304  NZ  LYS A 161     -19.588 -17.745   8.644  1.00 92.80           N  \\nATOM   1305  N   GLY A 162     -13.975 -13.362   8.571  1.00 94.95           N  \\nATOM   1306  CA  GLY A 162     -13.576 -13.003   7.218  1.00 94.95           C  \\nATOM   1307  C   GLY A 162     -12.820 -14.110   6.509  1.00 94.95           C  \\nATOM   1308  O   GLY A 162     -11.969 -14.791   7.086  1.00 94.95           O  \\nATOM   1309  N   ILE A 163     -13.182 -14.286   5.244  1.00 97.38           N  \\nATOM   1310  CA  ILE A 163     -12.644 -15.297   4.348  1.00 97.38           C  \\nATOM   1311  C   ILE A 163     -11.537 -14.663   3.514  1.00 97.38           C  \\nATOM   1312  CB  ILE A 163     -13.776 -15.880   3.474  1.00 97.38           C  \\nATOM   1313  O   ILE A 163     -11.797 -13.709   2.777  1.00 97.38           O  \\nATOM   1314  CG1 ILE A 163     -14.998 -16.363   4.292  1.00 97.38           C  \\nATOM   1315  CG2 ILE A 163     -13.227 -17.025   2.613  1.00 97.38           C  \\nATOM   1316  CD1 ILE A 163     -14.693 -17.337   5.439  1.00 97.38           C  \\nATOM   1317  N   LEU A 164     -10.312 -15.185   3.620  1.00 96.73           N  \\nATOM   1318  CA  LEU A 164      -9.215 -14.743   2.759  1.00 96.73           C  \\nATOM   1319  C   LEU A 164      -9.559 -15.075   1.304  1.00 96.73           C  \\nATOM   1320  CB  LEU A 164      -7.898 -15.400   3.209  1.00 96.73           C  \\nATOM   1321  O   LEU A 164      -9.832 -16.233   0.987  1.00 96.73           O  \\nATOM   1322  CG  LEU A 164      -6.719 -15.139   2.251  1.00 96.73           C  \\nATOM   1323  CD1 LEU A 164      -6.249 -13.688   2.226  1.00 96.73           C  \\nATOM   1324  CD2 LEU A 164      -5.515 -15.969   2.662  1.00 96.73           C  \\nATOM   1325  N   LEU A 165      -9.533 -14.074   0.427  1.00 94.26           N  \\nATOM   1326  CA  LEU A 165      -9.818 -14.265  -0.995  1.00 94.26           C  \\nATOM   1327  C   LEU A 165      -8.589 -14.794  -1.728  1.00 94.26           C  \\nATOM   1328  CB  LEU A 165     -10.316 -12.945  -1.606  1.00 94.26           C  \\nATOM   1329  O   LEU A 165      -8.634 -15.856  -2.341  1.00 94.26           O  \\nATOM   1330  CG  LEU A 165     -11.676 -12.475  -1.066  1.00 94.26           C  \\nATOM   1331  CD1 LEU A 165     -12.042 -11.139  -1.709  1.00 94.26           C  \\nATOM   1332  CD2 LEU A 165     -12.778 -13.496  -1.369  1.00 94.26           C  \\nATOM   1333  N   ASN A 166      -7.486 -14.063  -1.622  1.00 91.65           N  \\nATOM   1334  CA  ASN A 166      -6.234 -14.385  -2.281  1.00 91.65           C  \\nATOM   1335  C   ASN A 166      -5.067 -13.754  -1.522  1.00 91.65           C  \\nATOM   1336  CB  ASN A 166      -6.291 -13.911  -3.744  1.00 91.65           C  \\nATOM   1337  O   ASN A 166      -5.181 -12.656  -0.972  1.00 91.65           O  \\nATOM   1338  CG  ASN A 166      -6.509 -12.415  -3.872  1.00 91.65           C  \\nATOM   1339  ND2 ASN A 166      -5.471 -11.658  -4.138  1.00 91.65           N  \\nATOM   1340  OD1 ASN A 166      -7.603 -11.899  -3.709  1.00 91.65           O  \\nATOM   1341  N   TRP A 167      -3.923 -14.425  -1.519  1.00 90.40           N  \\nATOM   1342  CA  TRP A 167      -2.702 -13.856  -0.981  1.00 90.40           C  \\nATOM   1343  C   TRP A 167      -2.137 -12.768  -1.897  1.00 90.40           C  \\nATOM   1344  CB  TRP A 167      -1.666 -14.944  -0.717  1.00 90.40           C  \\nATOM   1345  O   TRP A 167      -2.183 -12.839  -3.126  1.00 90.40           O  \\nATOM   1346  CG  TRP A 167      -1.952 -15.845   0.440  1.00 90.40           C  \\nATOM   1347  CD1 TRP A 167      -2.144 -17.180   0.375  1.00 90.40           C  \\nATOM   1348  CD2 TRP A 167      -2.079 -15.488   1.848  1.00 90.40           C  \\nATOM   1349  CE2 TRP A 167      -2.278 -16.682   2.600  1.00 90.40           C  \\nATOM   1350  CE3 TRP A 167      -2.045 -14.274   2.568  1.00 90.40           C  \\nATOM   1351  NE1 TRP A 167      -2.307 -17.682   1.651  1.00 90.40           N  \\nATOM   1352  CH2 TRP A 167      -2.369 -15.447   4.683  1.00 90.40           C  \\nATOM   1353  CZ2 TRP A 167      -2.393 -16.670   3.999  1.00 90.40           C  \\nATOM   1354  CZ3 TRP A 167      -2.200 -14.253   3.966  1.00 90.40           C  \\nATOM   1355  N   THR A 168      -1.539 -11.759  -1.272  1.00 85.13           N  \\nATOM   1356  CA  THR A 168      -0.785 -10.689  -1.934  1.00 85.13           C  \\nATOM   1357  C   THR A 168       0.541 -10.491  -1.202  1.00 85.13           C  \\nATOM   1358  CB  THR A 168      -1.600  -9.384  -2.016  1.00 85.13           C  \\nATOM   1359  O   THR A 168       0.911 -11.282  -0.329  1.00 85.13           O  \\nATOM   1360  CG2 THR A 168      -2.957  -9.564  -2.690  1.00 85.13           C  \\nATOM   1361  OG1 THR A 168      -1.817  -8.853  -0.732  1.00 85.13           O  \\nATOM   1362  N   LYS A 169       1.328  -9.473  -1.576  1.00 82.52           N  \\nATOM   1363  CA  LYS A 169       2.564  -9.086  -0.863  1.00 82.52           C  \\nATOM   1364  C   LYS A 169       3.621 -10.204  -0.744  1.00 82.52           C  \\nATOM   1365  CB  LYS A 169       2.193  -8.440   0.496  1.00 82.52           C  \\nATOM   1366  O   LYS A 169       4.656  -9.999  -0.122  1.00 82.52           O  \\nATOM   1367  CG  LYS A 169       1.319  -7.176   0.333  1.00 82.52           C  \\nATOM   1368  CD  LYS A 169       0.618  -6.732   1.630  1.00 82.52           C  \\nATOM   1369  CE  LYS A 169      -0.258  -5.505   1.312  1.00 82.52           C  \\nATOM   1370  NZ  LYS A 169      -1.140  -5.081   2.433  1.00 82.52           N  \\nATOM   1371  N   GLY A 170       3.480 -11.314  -1.480  1.00 80.61           N  \\nATOM   1372  CA  GLY A 170       4.427 -12.442  -1.535  1.00 80.61           C  \\nATOM   1373  C   GLY A 170       4.076 -13.641  -0.655  1.00 80.61           C  \\nATOM   1374  O   GLY A 170       4.806 -14.625  -0.697  1.00 80.61           O  \\nATOM   1375  N   PHE A 171       2.982 -13.578   0.103  1.00 89.34           N  \\nATOM   1376  CA  PHE A 171       2.478 -14.728   0.851  1.00 89.34           C  \\nATOM   1377  C   PHE A 171       1.916 -15.785  -0.104  1.00 89.34           C  \\nATOM   1378  CB  PHE A 171       1.424 -14.265   1.862  1.00 89.34           C  \\nATOM   1379  O   PHE A 171       1.406 -15.445  -1.172  1.00 89.34           O  \\nATOM   1380  CG  PHE A 171       2.015 -13.628   3.103  1.00 89.34           C  \\nATOM   1381  CD1 PHE A 171       1.962 -14.315   4.331  1.00 89.34           C  \\nATOM   1382  CD2 PHE A 171       2.633 -12.363   3.037  1.00 89.34           C  \\nATOM   1383  CE1 PHE A 171       2.509 -13.736   5.488  1.00 89.34           C  \\nATOM   1384  CE2 PHE A 171       3.192 -11.792   4.194  1.00 89.34           C  \\nATOM   1385  CZ  PHE A 171       3.122 -12.474   5.418  1.00 89.34           C  \\nATOM   1386  N   LYS A 172       2.035 -17.062   0.277  1.00 89.79           N  \\nATOM   1387  CA  LYS A 172       1.477 -18.227  -0.436  1.00 89.79           C  \\nATOM   1388  C   LYS A 172       1.079 -19.367   0.511  1.00 89.79           C  \\nATOM   1389  CB  LYS A 172       2.446 -18.730  -1.530  1.00 89.79           C  \\nATOM   1390  O   LYS A 172       1.045 -20.520   0.094  1.00 89.79           O  \\nATOM   1391  CG  LYS A 172       2.618 -17.729  -2.677  1.00 89.79           C  \\nATOM   1392  CD  LYS A 172       3.224 -18.370  -3.928  1.00 89.79           C  \\nATOM   1393  CE  LYS A 172       3.239 -17.287  -5.008  1.00 89.79           C  \\nATOM   1394  NZ  LYS A 172       3.507 -17.816  -6.365  1.00 89.79           N  \\nATOM   1395  N   ALA A 173       0.804 -19.066   1.781  1.00 93.22           N  \\nATOM   1396  CA  ALA A 173       0.477 -20.078   2.781  1.00 93.22           C  \\nATOM   1397  C   ALA A 173      -0.770 -20.884   2.365  1.00 93.22           C  \\nATOM   1398  CB  ALA A 173       0.332 -19.407   4.151  1.00 93.22           C  \\nATOM   1399  O   ALA A 173      -1.904 -20.393   2.370  1.00 93.22           O  \\nATOM   1400  N   SER A 174      -0.544 -22.132   1.965  1.00 95.32           N  \\nATOM   1401  CA  SER A 174      -1.569 -23.014   1.409  1.00 95.32           C  \\nATOM   1402  C   SER A 174      -2.645 -23.366   2.441  1.00 95.32           C  \\nATOM   1403  CB  SER A 174      -0.923 -24.271   0.817  1.00 95.32           C  \\nATOM   1404  O   SER A 174      -2.359 -23.548   3.624  1.00 95.32           O  \\nATOM   1405  OG  SER A 174      -0.124 -24.945   1.771  1.00 95.32           O  \\nATOM   1406  N   GLY A 175      -3.902 -23.451   2.000  1.00 95.88           N  \\nATOM   1407  CA  GLY A 175      -5.046 -23.744   2.872  1.00 95.88           C  \\nATOM   1408  C   GLY A 175      -5.612 -22.540   3.634  1.00 95.88           C  \\nATOM   1409  O   GLY A 175      -6.574 -22.708   4.374  1.00 95.88           O  \\nATOM   1410  N   ALA A 176      -5.055 -21.336   3.462  1.00 96.06           N  \\nATOM   1411  CA  ALA A 176      -5.637 -20.123   4.037  1.00 96.06           C  \\nATOM   1412  C   ALA A 176      -6.679 -19.477   3.112  1.00 96.06           C  \\nATOM   1413  CB  ALA A 176      -4.514 -19.146   4.358  1.00 96.06           C  \\nATOM   1414  O   ALA A 176      -7.714 -19.014   3.585  1.00 96.06           O  \\nATOM   1415  N   GLU A 177      -6.421 -19.449   1.800  1.00 96.13           N  \\nATOM   1416  CA  GLU A 177      -7.372 -18.920   0.815  1.00 96.13           C  \\nATOM   1417  C   GLU A 177      -8.678 -19.725   0.863  1.00 96.13           C  \\nATOM   1418  CB  GLU A 177      -6.768 -18.931  -0.598  1.00 96.13           C  \\nATOM   1419  O   GLU A 177      -8.672 -20.947   1.036  1.00 96.13           O  \\nATOM   1420  CG  GLU A 177      -5.578 -17.966  -0.731  1.00 96.13           C  \\nATOM   1421  CD  GLU A 177      -4.924 -17.991  -2.123  1.00 96.13           C  \\nATOM   1422  OE1 GLU A 177      -4.199 -17.017  -2.431  1.00 96.13           O  \\nATOM   1423  OE2 GLU A 177      -5.069 -19.006  -2.838  1.00 96.13           O  \\nATOM   1424  N   GLY A 178      -9.809 -19.027   0.786  1.00 96.55           N  \\nATOM   1425  CA  GLY A 178     -11.143 -19.605   0.940  1.00 96.55           C  \\nATOM   1426  C   GLY A 178     -11.528 -19.983   2.377  1.00 96.55           C  \\nATOM   1427  O   GLY A 178     -12.643 -20.458   2.584  1.00 96.55           O  \\nATOM   1428  N   ASN A 179     -10.665 -19.759   3.376  1.00 97.11           N  \\nATOM   1429  CA  ASN A 179     -10.917 -20.130   4.771  1.00 97.11           C  \\nATOM   1430  C   ASN A 179     -11.054 -18.912   5.696  1.00 97.11           C  \\nATOM   1431  CB  ASN A 179      -9.843 -21.124   5.245  1.00 97.11           C  \\nATOM   1432  O   ASN A 179     -10.570 -17.816   5.409  1.00 97.11           O  \\nATOM   1433  CG  ASN A 179     -10.032 -22.483   4.602  1.00 97.11           C  \\nATOM   1434  ND2 ASN A 179      -9.471 -22.721   3.441  1.00 97.11           N  \\nATOM   1435  OD1 ASN A 179     -10.743 -23.328   5.120  1.00 97.11           O  \\nATOM   1436  N   ASN A 180     -11.733 -19.119   6.831  1.00 96.72           N  \\nATOM   1437  CA  ASN A 180     -11.929 -18.089   7.851  1.00 96.72           C  \\nATOM   1438  C   ASN A 180     -10.626 -17.821   8.616  1.00 96.72           C  \\nATOM   1439  CB  ASN A 180     -13.073 -18.502   8.797  1.00 96.72           C  \\nATOM   1440  O   ASN A 180     -10.203 -18.648   9.425  1.00 96.72           O  \\nATOM   1441  CG  ASN A 180     -13.312 -17.490   9.911  1.00 96.72           C  \\nATOM   1442  ND2 ASN A 180     -14.085 -17.843  10.910  1.00 96.72           N  \\nATOM   1443  OD1 ASN A 180     -12.806 -16.381   9.929  1.00 96.72           O  \\nATOM   1444  N   VAL A 181     -10.046 -16.637   8.421  1.00 96.62           N  \\nATOM   1445  CA  VAL A 181      -8.781 -16.204   9.037  1.00 96.62           C  \\nATOM   1446  C   VAL A 181      -8.849 -16.231  10.566  1.00 96.62           C  \\nATOM   1447  CB  VAL A 181      -8.435 -14.790   8.532  1.00 96.62           C  \\nATOM   1448  O   VAL A 181      -7.937 -16.733  11.224  1.00 96.62           O  \\nATOM   1449  CG1 VAL A 181      -7.224 -14.184   9.245  1.00 96.62           C  \\nATOM   1450  CG2 VAL A 181      -8.149 -14.805   7.025  1.00 96.62           C  \\nATOM   1451  N   VAL A 182      -9.956 -15.759  11.147  1.00 95.63           N  \\nATOM   1452  CA  VAL A 182     -10.154 -15.778  12.604  1.00 95.63           C  \\nATOM   1453  C   VAL A 182     -10.295 -17.210  13.120  1.00 95.63           C  \\nATOM   1454  CB  VAL A 182     -11.363 -14.909  13.003  1.00 95.63           C  \\nATOM   1455  O   VAL A 182      -9.796 -17.527  14.198  1.00 95.63           O  \\nATOM   1456  CG1 VAL A 182     -11.667 -15.016  14.501  1.00 95.63           C  \\nATOM   1457  CG2 VAL A 182     -11.067 -13.446  12.651  1.00 95.63           C  \\nATOM   1458  N   GLY A 183     -10.918 -18.095  12.339  1.00 95.97           N  \\nATOM   1459  CA  GLY A 183     -10.987 -19.527  12.640  1.00 95.97           C  \\nATOM   1460  C   GLY A 183      -9.600 -20.166  12.698  1.00 95.97           C  \\nATOM   1461  O   GLY A 183      -9.263 -20.795  13.696  1.00 95.97           O  \\nATOM   1462  N   LEU A 184      -8.766 -19.914  11.684  1.00 97.06           N  \\nATOM   1463  CA  LEU A 184      -7.391 -20.421  11.619  1.00 97.06           C  \\nATOM   1464  C   LEU A 184      -6.544 -19.950  12.812  1.00 97.06           C  \\nATOM   1465  CB  LEU A 184      -6.747 -19.974  10.294  1.00 97.06           C  \\nATOM   1466  O   LEU A 184      -5.822 -20.749  13.414  1.00 97.06           O  \\nATOM   1467  CG  LEU A 184      -7.382 -20.576   9.027  1.00 97.06           C  \\nATOM   1468  CD1 LEU A 184      -6.853 -19.870   7.780  1.00 97.06           C  \\nATOM   1469  CD2 LEU A 184      -7.074 -22.068   8.895  1.00 97.06           C  \\nATOM   1470  N   LEU A 185      -6.673 -18.676  13.198  1.00 96.68           N  \\nATOM   1471  CA  LEU A 185      -6.004 -18.130  14.379  1.00 96.68           C  \\nATOM   1472  C   LEU A 185      -6.511 -18.776  15.681  1.00 96.68           C  \\nATOM   1473  CB  LEU A 185      -6.186 -16.601  14.387  1.00 96.68           C  \\nATOM   1474  O   LEU A 185      -5.706 -19.158  16.532  1.00 96.68           O  \\nATOM   1475  CG  LEU A 185      -5.550 -15.904  15.604  1.00 96.68           C  \\nATOM   1476  CD1 LEU A 185      -4.038 -16.126  15.682  1.00 96.68           C  \\nATOM   1477  CD2 LEU A 185      -5.810 -14.401  15.539  1.00 96.68           C  \\nATOM   1478  N   ARG A 186      -7.834 -18.926  15.841  1.00 95.31           N  \\nATOM   1479  CA  ARG A 186      -8.446 -19.579  17.014  1.00 95.31           C  \\nATOM   1480  C   ARG A 186      -7.979 -21.032  17.145  1.00 95.31           C  \\nATOM   1481  CB  ARG A 186      -9.986 -19.486  16.939  1.00 95.31           C  \\nATOM   1482  O   ARG A 186      -7.646 -21.463  18.250  1.00 95.31           O  \\nATOM   1483  CG  ARG A 186     -10.549 -18.097  17.314  1.00 95.31           C  \\nATOM   1484  CD  ARG A 186     -12.075 -18.015  17.087  1.00 95.31           C  \\nATOM   1485  NE  ARG A 186     -12.661 -16.704  17.484  1.00 95.31           N  \\nATOM   1486  NH1 ARG A 186     -14.656 -16.815  16.327  1.00 95.31           N  \\nATOM   1487  NH2 ARG A 186     -14.198 -14.969  17.420  1.00 95.31           N  \\nATOM   1488  CZ  ARG A 186     -13.820 -16.174  17.091  1.00 95.31           C  \\nATOM   1489  N   ASP A 187      -7.891 -21.761  16.036  1.00 96.37           N  \\nATOM   1490  CA  ASP A 187      -7.407 -23.141  16.023  1.00 96.37           C  \\nATOM   1491  C   ASP A 187      -5.929 -23.235  16.425  1.00 96.37           C  \\nATOM   1492  CB  ASP A 187      -7.643 -23.775  14.645  1.00 96.37           C  \\nATOM   1493  O   ASP A 187      -5.574 -24.099  17.227  1.00 96.37           O  \\nATOM   1494  CG  ASP A 187      -9.111 -24.089  14.341  1.00 96.37           C  \\nATOM   1495  OD1 ASP A 187      -9.906 -24.215  15.305  1.00 96.37           O  \\nATOM   1496  OD2 ASP A 187      -9.402 -24.303  13.145  1.00 96.37           O  \\nATOM   1497  N   ALA A 188      -5.078 -22.318  15.951  1.00 97.04           N  \\nATOM   1498  CA  ALA A 188      -3.666 -22.259  16.341  1.00 97.04           C  \\nATOM   1499  C   ALA A 188      -3.479 -21.981  17.839  1.00 97.04           C  \\nATOM   1500  CB  ALA A 188      -2.968 -21.200  15.486  1.00 97.04           C  \\nATOM   1501  O   ALA A 188      -2.727 -22.679  18.523  1.00 97.04           O  \\nATOM   1502  N   ILE A 189      -4.223 -21.014  18.383  1.00 95.02           N  \\nATOM   1503  CA  ILE A 189      -4.211 -20.707  19.822  1.00 95.02           C  \\nATOM   1504  C   ILE A 189      -4.666 -21.926  20.634  1.00 95.02           C  \\nATOM   1505  CB  ILE A 189      -5.075 -19.457  20.103  1.00 95.02           C  \\nATOM   1506  O   ILE A 189      -4.026 -22.291  21.621  1.00 95.02           O  \\nATOM   1507  CG1 ILE A 189      -4.421 -18.212  19.458  1.00 95.02           C  \\nATOM   1508  CG2 ILE A 189      -5.259 -19.243  21.619  1.00 95.02           C  \\nATOM   1509  CD1 ILE A 189      -5.347 -16.992  19.402  1.00 95.02           C  \\nATOM   1510  N   LYS A 190      -5.730 -22.608  20.193  1.00 95.16           N  \\nATOM   1511  CA  LYS A 190      -6.240 -23.812  20.856  1.00 95.16           C  \\nATOM   1512  C   LYS A 190      -5.250 -24.979  20.806  1.00 95.16           C  \\nATOM   1513  CB  LYS A 190      -7.585 -24.184  20.227  1.00 95.16           C  \\nATOM   1514  O   LYS A 190      -5.120 -25.682  21.806  1.00 95.16           O  \\nATOM   1515  CG  LYS A 190      -8.245 -25.364  20.950  1.00 95.16           C  \\nATOM   1516  CD  LYS A 190      -9.587 -25.672  20.290  1.00 95.16           C  \\nATOM   1517  CE  LYS A 190     -10.233 -26.884  20.961  1.00 95.16           C  \\nATOM   1518  NZ  LYS A 190     -11.504 -27.219  20.278  1.00 95.16           N  \\nATOM   1519  N   ARG A 191      -4.565 -25.198  19.675  1.00 96.74           N  \\nATOM   1520  CA  ARG A 191      -3.508 -26.219  19.544  1.00 96.74           C  \\nATOM   1521  C   ARG A 191      -2.360 -25.965  20.517  1.00 96.74           C  \\nATOM   1522  CB  ARG A 191      -2.950 -26.258  18.109  1.00 96.74           C  \\nATOM   1523  O   ARG A 191      -1.844 -26.920  21.091  1.00 96.74           O  \\nATOM   1524  CG  ARG A 191      -3.834 -27.023  17.113  1.00 96.74           C  \\nATOM   1525  CD  ARG A 191      -3.109 -27.213  15.768  1.00 96.74           C  \\nATOM   1526  NE  ARG A 191      -2.840 -25.940  15.073  1.00 96.74           N  \\nATOM   1527  NH1 ARG A 191      -4.845 -25.720  13.971  1.00 96.74           N  \\nATOM   1528  NH2 ARG A 191      -3.267 -24.162  13.751  1.00 96.74           N  \\nATOM   1529  CZ  ARG A 191      -3.654 -25.285  14.270  1.00 96.74           C  \\nATOM   1530  N   ARG A 192      -1.984 -24.698  20.718  1.00 94.64           N  \\nATOM   1531  CA  ARG A 192      -0.926 -24.313  21.659  1.00 94.64           C  \\nATOM   1532  C   ARG A 192      -1.342 -24.500  23.122  1.00 94.64           C  \\nATOM   1533  CB  ARG A 192      -0.491 -22.877  21.353  1.00 94.64           C  \\nATOM   1534  O   ARG A 192      -0.592 -25.093  23.892  1.00 94.64           O  \\nATOM   1535  CG  ARG A 192       0.772 -22.530  22.147  1.00 94.64           C  \\nATOM   1536  CD  ARG A 192       1.203 -21.090  21.864  1.00 94.64           C  \\nATOM   1537  NE  ARG A 192       1.872 -21.004  20.555  1.00 94.64           N  \\nATOM   1538  NH1 ARG A 192       3.996 -21.481  21.269  1.00 94.64           N  \\nATOM   1539  NH2 ARG A 192       3.568 -21.408  19.083  1.00 94.64           N  \\nATOM   1540  CZ  ARG A 192       3.135 -21.299  20.306  1.00 94.64           C  \\nATOM   1541  N   GLY A 193      -2.530 -24.022  23.496  1.00 93.23           N  \\nATOM   1542  CA  GLY A 193      -3.185 -24.342  24.771  1.00 93.23           C  \\nATOM   1543  C   GLY A 193      -2.636 -23.666  26.037  1.00 93.23           C  \\nATOM   1544  O   GLY A 193      -3.010 -24.079  27.132  1.00 93.23           O  \\nATOM   1545  N   ASP A 194      -1.772 -22.651  25.932  1.00 93.22           N  \\nATOM   1546  CA  ASP A 194      -1.150 -21.963  27.080  1.00 93.22           C  \\nATOM   1547  C   ASP A 194      -1.712 -20.557  27.374  1.00 93.22           C  \\nATOM   1548  CB  ASP A 194       0.378 -21.949  26.907  1.00 93.22           C  \\nATOM   1549  O   ASP A 194      -1.338 -19.945  28.377  1.00 93.22           O  \\nATOM   1550  CG  ASP A 194       0.866 -21.039  25.777  1.00 93.22           C  \\nATOM   1551  OD1 ASP A 194       0.147 -20.881  24.771  1.00 93.22           O  \\nATOM   1552  OD2 ASP A 194       1.983 -20.483  25.903  1.00 93.22           O  \\nATOM   1553  N   PHE A 195      -2.621 -20.047  26.539  1.00 93.21           N  \\nATOM   1554  CA  PHE A 195      -3.395 -18.826  26.782  1.00 93.21           C  \\nATOM   1555  C   PHE A 195      -4.744 -18.872  26.046  1.00 93.21           C  \\nATOM   1556  CB  PHE A 195      -2.576 -17.583  26.383  1.00 93.21           C  \\nATOM   1557  O   PHE A 195      -4.942 -19.659  25.120  1.00 93.21           O  \\nATOM   1558  CG  PHE A 195      -2.262 -17.477  24.902  1.00 93.21           C  \\nATOM   1559  CD1 PHE A 195      -1.097 -18.062  24.383  1.00 93.21           C  \\nATOM   1560  CD2 PHE A 195      -3.144 -16.812  24.034  1.00 93.21           C  \\nATOM   1561  CE1 PHE A 195      -0.833 -18.013  23.005  1.00 93.21           C  \\nATOM   1562  CE2 PHE A 195      -2.870 -16.760  22.655  1.00 93.21           C  \\nATOM   1563  CZ  PHE A 195      -1.711 -17.355  22.139  1.00 93.21           C  \\nATOM   1564  N   GLU A 196      -5.671 -18.001  26.443  1.00 89.91           N  \\nATOM   1565  CA  GLU A 196      -6.952 -17.799  25.759  1.00 89.91           C  \\nATOM   1566  C   GLU A 196      -7.050 -16.384  25.189  1.00 89.91           C  \\nATOM   1567  CB  GLU A 196      -8.142 -18.035  26.698  1.00 89.91           C  \\nATOM   1568  O   GLU A 196      -6.551 -15.426  25.780  1.00 89.91           O  \\nATOM   1569  CG  GLU A 196      -8.361 -19.506  27.077  1.00 89.91           C  \\nATOM   1570  CD  GLU A 196      -9.680 -19.717  27.846  1.00 89.91           C  \\nATOM   1571  OE1 GLU A 196      -9.804 -20.781  28.488  1.00 89.91           O  \\nATOM   1572  OE2 GLU A 196     -10.590 -18.841  27.763  1.00 89.91           O  \\nATOM   1573  N   MET A 197      -7.752 -16.243  24.065  1.00 86.16           N  \\nATOM   1574  CA  MET A 197      -8.072 -14.947  23.468  1.00 86.16           C  \\nATOM   1575  C   MET A 197      -9.505 -14.904  22.982  1.00 86.16           C  \\nATOM   1576  CB  MET A 197      -7.174 -14.648  22.272  1.00 86.16           C  \\nATOM   1577  O   MET A 197     -10.088 -15.936  22.648  1.00 86.16           O  \\nATOM   1578  CG  MET A 197      -5.728 -14.555  22.701  1.00 86.16           C  \\nATOM   1579  SD  MET A 197      -4.702 -13.979  21.349  1.00 86.16           S  \\nATOM   1580  CE  MET A 197      -3.826 -12.740  22.285  1.00 86.16           C  \\nATOM   1581  N   ASP A 198     -10.027 -13.688  22.891  1.00 88.89           N  \\nATOM   1582  CA  ASP A 198     -11.317 -13.413  22.286  1.00 88.89           C  \\nATOM   1583  C   ASP A 198     -11.131 -12.440  21.119  1.00 88.89           C  \\nATOM   1584  CB  ASP A 198     -12.259 -12.889  23.376  1.00 88.89           C  \\nATOM   1585  O   ASP A 198     -10.946 -11.243  21.328  1.00 88.89           O  \\nATOM   1586  CG  ASP A 198     -13.711 -12.854  22.909  1.00 88.89           C  \\nATOM   1587  OD1 ASP A 198     -14.000 -13.501  21.877  1.00 88.89           O  \\nATOM   1588  OD2 ASP A 198     -14.518 -12.268  23.660  1.00 88.89           O  \\nATOM   1589  N   VAL A 199     -11.084 -12.962  19.888  1.00 93.03           N  \\nATOM   1590  CA  VAL A 199     -11.050 -12.122  18.679  1.00 93.03           C  \\nATOM   1591  C   VAL A 199     -12.428 -11.509  18.510  1.00 93.03           C  \\nATOM   1592  CB  VAL A 199     -10.644 -12.886  17.404  1.00 93.03           C  \\nATOM   1593  O   VAL A 199     -13.359 -12.229  18.159  1.00 93.03           O  \\nATOM   1594  CG1 VAL A 199     -10.545 -11.921  16.211  1.00 93.03           C  \\nATOM   1595  CG2 VAL A 199      -9.285 -13.578  17.545  1.00 93.03           C  \\nATOM   1596  N   VAL A 200     -12.529 -10.206  18.768  1.00 93.35           N  \\nATOM   1597  CA  VAL A 200     -13.789  -9.447  18.718  1.00 93.35           C  \\nATOM   1598  C   VAL A 200     -13.921  -8.611  17.449  1.00 93.35           C  \\nATOM   1599  CB  VAL A 200     -13.957  -8.549  19.958  1.00 93.35           C  \\nATOM   1600  O   VAL A 200     -15.015  -8.170  17.113  1.00 93.35           O  \\nATOM   1601  CG1 VAL A 200     -14.034  -9.375  21.245  1.00 93.35           C  \\nATOM   1602  CG2 VAL A 200     -12.830  -7.518  20.105  1.00 93.35           C  \\nATOM   1603  N   ALA A 201     -12.808  -8.374  16.755  1.00 93.65           N  \\nATOM   1604  CA  ALA A 201     -12.792  -7.673  15.484  1.00 93.65           C  \\nATOM   1605  C   ALA A 201     -11.595  -8.108  14.637  1.00 93.65           C  \\nATOM   1606  CB  ALA A 201     -12.760  -6.160  15.738  1.00 93.65           C  \\nATOM   1607  O   ALA A 201     -10.490  -8.315  15.144  1.00 93.65           O  \\nATOM   1608  N   MET A 202     -11.809  -8.184  13.330  1.00 94.70           N  \\nATOM   1609  CA  MET A 202     -10.775  -8.287  12.317  1.00 94.70           C  \\nATOM   1610  C   MET A 202     -10.983  -7.168  11.300  1.00 94.70           C  \\nATOM   1611  CB  MET A 202     -10.809  -9.673  11.672  1.00 94.70           C  \\nATOM   1612  O   MET A 202     -12.105  -6.920  10.871  1.00 94.70           O  \\nATOM   1613  CG  MET A 202      -9.650  -9.857  10.685  1.00 94.70           C  \\nATOM   1614  SD  MET A 202      -9.585 -11.479   9.893  1.00 94.70           S  \\nATOM   1615  CE  MET A 202     -11.117 -11.403   8.947  1.00 94.70           C  \\nATOM   1616  N   VAL A 203      -9.911  -6.485  10.915  1.00 95.14           N  \\nATOM   1617  CA  VAL A 203      -9.963  -5.352   9.985  1.00 95.14           C  \\nATOM   1618  C   VAL A 203      -8.778  -5.373   9.029  1.00 95.14           C  \\nATOM   1619  CB  VAL A 203     -10.035  -4.004  10.730  1.00 95.14           C  \\nATOM   1620  O   VAL A 203      -7.734  -5.947   9.327  1.00 95.14           O  \\nATOM   1621  CG1 VAL A 203     -11.371  -3.836  11.458  1.00 95.14           C  \\nATOM   1622  CG2 VAL A 203      -8.895  -3.786  11.734  1.00 95.14           C  \\nATOM   1623  N   ASN A 204      -8.923  -4.721   7.878  1.00 94.92           N  \\nATOM   1624  CA  ASN A 204      -7.790  -4.434   7.001  1.00 94.92           C  \\nATOM   1625  C   ASN A 204      -6.929  -3.292   7.580  1.00 94.92           C  \\nATOM   1626  CB  ASN A 204      -8.330  -4.155   5.593  1.00 94.92           C  \\nATOM   1627  O   ASN A 204      -7.413  -2.474   8.367  1.00 94.92           O  \\nATOM   1628  CG  ASN A 204      -7.226  -3.996   4.568  1.00 94.92           C  \\nATOM   1629  ND2 ASN A 204      -6.674  -5.081   4.078  1.00 94.92           N  \\nATOM   1630  OD1 ASN A 204      -6.852  -2.890   4.216  1.00 94.92           O  \\nATOM   1631  N   ASP A 205      -5.657  -3.216   7.183  1.00 94.58           N  \\nATOM   1632  CA  ASP A 205      -4.729  -2.179   7.651  1.00 94.58           C  \\nATOM   1633  C   ASP A 205      -5.177  -0.768   7.279  1.00 94.58           C  \\nATOM   1634  CB  ASP A 205      -3.285  -2.461   7.191  1.00 94.58           C  \\nATOM   1635  O   ASP A 205      -5.083   0.131   8.110  1.00 94.58           O  \\nATOM   1636  CG  ASP A 205      -3.069  -2.737   5.691  1.00 94.58           C  \\nATOM   1637  OD1 ASP A 205      -4.038  -2.723   4.909  1.00 94.58           O  \\nATOM   1638  OD2 ASP A 205      -1.913  -3.055   5.316  1.00 94.58           O  \\nATOM   1639  N   THR A 206      -5.756  -0.586   6.093  1.00 95.88           N  \\nATOM   1640  CA  THR A 206      -6.367   0.690   5.688  1.00 95.88           C  \\nATOM   1641  C   THR A 206      -7.443   1.154   6.674  1.00 95.88           C  \\nATOM   1642  CB  THR A 206      -6.976   0.588   4.285  1.00 95.88           C  \\nATOM   1643  O   THR A 206      -7.415   2.302   7.123  1.00 95.88           O  \\nATOM   1644  CG2 THR A 206      -5.928   0.342   3.206  1.00 95.88           C  \\nATOM   1645  OG1 THR A 206      -7.911  -0.464   4.208  1.00 95.88           O  \\nATOM   1646  N   VAL A 207      -8.342   0.251   7.080  1.00 95.88           N  \\nATOM   1647  CA  VAL A 207      -9.445   0.525   8.018  1.00 95.88           C  \\nATOM   1648  C   VAL A 207      -8.897   0.887   9.388  1.00 95.88           C  \\nATOM   1649  CB  VAL A 207     -10.387  -0.686   8.138  1.00 95.88           C  \\nATOM   1650  O   VAL A 207      -9.314   1.877   9.985  1.00 95.88           O  \\nATOM   1651  CG1 VAL A 207     -11.580  -0.404   9.061  1.00 95.88           C  \\nATOM   1652  CG2 VAL A 207     -10.931  -1.129   6.777  1.00 95.88           C  \\nATOM   1653  N   ALA A 208      -7.921   0.125   9.878  1.00 95.26           N  \\nATOM   1654  CA  ALA A 208      -7.274   0.431  11.143  1.00 95.26           C  \\nATOM   1655  C   ALA A 208      -6.569   1.802  11.105  1.00 95.26           C  \\nATOM   1656  CB  ALA A 208      -6.328  -0.717  11.475  1.00 95.26           C  \\nATOM   1657  O   ALA A 208      -6.763   2.614  12.010  1.00 95.26           O  \\nATOM   1658  N   THR A 209      -5.835   2.114  10.036  1.00 95.63           N  \\nATOM   1659  CA  THR A 209      -5.224   3.435   9.836  1.00 95.63           C  \\nATOM   1660  C   THR A 209      -6.267   4.555   9.845  1.00 95.63           C  \\nATOM   1661  CB  THR A 209      -4.410   3.442   8.533  1.00 95.63           C  \\nATOM   1662  O   THR A 209      -6.071   5.545  10.551  1.00 95.63           O  \\nATOM   1663  CG2 THR A 209      -3.883   4.817   8.133  1.00 95.63           C  \\nATOM   1664  OG1 THR A 209      -3.279   2.627   8.714  1.00 95.63           O  \\nATOM   1665  N   MET A 210      -7.393   4.388   9.141  1.00 96.29           N  \\nATOM   1666  CA  MET A 210      -8.489   5.364   9.138  1.00 96.29           C  \\nATOM   1667  C   MET A 210      -9.025   5.604  10.549  1.00 96.29           C  \\nATOM   1668  CB  MET A 210      -9.639   4.874   8.248  1.00 96.29           C  \\nATOM   1669  O   MET A 210      -9.120   6.746  10.981  1.00 96.29           O  \\nATOM   1670  CG  MET A 210     -10.691   5.962   8.009  1.00 96.29           C  \\nATOM   1671  SD  MET A 210     -12.088   5.395   7.004  1.00 96.29           S  \\nATOM   1672  CE  MET A 210     -12.898   4.309   8.207  1.00 96.29           C  \\nATOM   1673  N   ILE A 211      -9.336   4.535  11.287  1.00 93.69           N  \\nATOM   1674  CA  ILE A 211      -9.911   4.624  12.634  1.00 93.69           C  \\nATOM   1675  C   ILE A 211      -8.920   5.234  13.630  1.00 93.69           C  \\nATOM   1676  CB  ILE A 211     -10.402   3.229  13.081  1.00 93.69           C  \\nATOM   1677  O   ILE A 211      -9.310   6.035  14.480  1.00 93.69           O  \\nATOM   1678  CG1 ILE A 211     -11.576   2.724  12.207  1.00 93.69           C  \\nATOM   1679  CG2 ILE A 211     -10.792   3.227  14.569  1.00 93.69           C  \\nATOM   1680  CD1 ILE A 211     -12.879   3.523  12.312  1.00 93.69           C  \\nATOM   1681  N   SER A 212      -7.635   4.899  13.513  1.00 91.80           N  \\nATOM   1682  CA  SER A 212      -6.592   5.497  14.346  1.00 91.80           C  \\nATOM   1683  C   SER A 212      -6.480   7.005  14.122  1.00 91.80           C  \\nATOM   1684  CB  SER A 212      -5.247   4.834  14.064  1.00 91.80           C  \\nATOM   1685  O   SER A 212      -6.331   7.746  15.088  1.00 91.80           O  \\nATOM   1686  OG  SER A 212      -4.287   5.309  14.989  1.00 91.80           O  \\nATOM   1687  N   CYS A 213      -6.554   7.462  12.871  1.00 92.71           N  \\nATOM   1688  CA  CYS A 213      -6.515   8.886  12.544  1.00 92.71           C  \\nATOM   1689  C   CYS A 213      -7.844   9.593  12.852  1.00 92.71           C  \\nATOM   1690  CB  CYS A 213      -6.111   9.039  11.075  1.00 92.71           C  \\nATOM   1691  O   CYS A 213      -7.823  10.747  13.265  1.00 92.71           O  \\nATOM   1692  SG  CYS A 213      -4.368   8.571  10.858  1.00 92.71           S  \\nATOM   1693  N   TYR A 214      -8.984   8.903  12.738  1.00 91.52           N  \\nATOM   1694  CA  TYR A 214     -10.296   9.438  13.117  1.00 91.52           C  \\nATOM   1695  C   TYR A 214     -10.348   9.866  14.579  1.00 91.52           C  \\nATOM   1696  CB  TYR A 214     -11.397   8.416  12.826  1.00 91.52           C  \\nATOM   1697  O   TYR A 214     -10.935  10.888  14.919  1.00 91.52           O  \\nATOM   1698  CG  TYR A 214     -12.776   8.993  13.070  1.00 91.52           C  \\nATOM   1699  CD1 TYR A 214     -13.323   9.026  14.368  1.00 91.52           C  \\nATOM   1700  CD2 TYR A 214     -13.480   9.575  12.003  1.00 91.52           C  \\nATOM   1701  CE1 TYR A 214     -14.580   9.618  14.589  1.00 91.52           C  \\nATOM   1702  CE2 TYR A 214     -14.741  10.154  12.211  1.00 91.52           C  \\nATOM   1703  OH  TYR A 214     -16.521  10.711  13.698  1.00 91.52           O  \\nATOM   1704  CZ  TYR A 214     -15.288  10.182  13.507  1.00 91.52           C  \\nATOM   1705  N   TYR A 215      -9.690   9.098  15.445  1.00 84.36           N  \\nATOM   1706  CA  TYR A 215      -9.577   9.437  16.856  1.00 84.36           C  \\nATOM   1707  C   TYR A 215      -8.896  10.807  17.087  1.00 84.36           C  \\nATOM   1708  CB  TYR A 215      -8.839   8.276  17.534  1.00 84.36           C  \\nATOM   1709  O   TYR A 215      -9.186  11.479  18.074  1.00 84.36           O  \\nATOM   1710  CG  TYR A 215      -8.569   8.523  18.993  1.00 84.36           C  \\nATOM   1711  CD1 TYR A 215      -7.447   9.291  19.338  1.00 84.36           C  \\nATOM   1712  CD2 TYR A 215      -9.486   8.111  19.977  1.00 84.36           C  \\nATOM   1713  CE1 TYR A 215      -7.229   9.670  20.667  1.00 84.36           C  \\nATOM   1714  CE2 TYR A 215      -9.281   8.499  21.314  1.00 84.36           C  \\nATOM   1715  OH  TYR A 215      -7.958   9.759  22.895  1.00 84.36           O  \\nATOM   1716  CZ  TYR A 215      -8.160   9.296  21.645  1.00 84.36           C  \\nATOM   1717  N   GLU A 216      -7.998  11.232  16.195  1.00 84.88           N  \\nATOM   1718  CA  GLU A 216      -7.307  12.530  16.270  1.00 84.88           C  \\nATOM   1719  C   GLU A 216      -8.062  13.633  15.520  1.00 84.88           C  \\nATOM   1720  CB  GLU A 216      -5.880  12.380  15.718  1.00 84.88           C  \\nATOM   1721  O   GLU A 216      -8.081  14.783  15.957  1.00 84.88           O  \\nATOM   1722  CG  GLU A 216      -5.049  11.438  16.602  1.00 84.88           C  \\nATOM   1723  CD  GLU A 216      -3.659  11.110  16.050  1.00 84.88           C  \\nATOM   1724  OE1 GLU A 216      -3.081  10.145  16.615  1.00 84.88           O  \\nATOM   1725  OE2 GLU A 216      -3.194  11.785  15.106  1.00 84.88           O  \\nATOM   1726  N   ASP A 217      -8.716  13.280  14.415  1.00 90.56           N  \\nATOM   1727  CA  ASP A 217      -9.524  14.179  13.602  1.00 90.56           C  \\nATOM   1728  C   ASP A 217     -10.779  13.465  13.089  1.00 90.56           C  \\nATOM   1729  CB  ASP A 217      -8.671  14.713  12.445  1.00 90.56           C  \\nATOM   1730  O   ASP A 217     -10.717  12.606  12.209  1.00 90.56           O  \\nATOM   1731  CG  ASP A 217      -9.414  15.716  11.561  1.00 90.56           C  \\nATOM   1732  OD1 ASP A 217     -10.615  15.981  11.804  1.00 90.56           O  \\nATOM   1733  OD2 ASP A 217      -8.775  16.203  10.603  1.00 90.56           O  \\nATOM   1734  N   HIS A 218     -11.944  13.891  13.580  1.00 90.50           N  \\nATOM   1735  CA  HIS A 218     -13.245  13.313  13.236  1.00 90.50           C  \\nATOM   1736  C   HIS A 218     -13.663  13.566  11.773  1.00 90.50           C  \\nATOM   1737  CB  HIS A 218     -14.308  13.845  14.211  1.00 90.50           C  \\nATOM   1738  O   HIS A 218     -14.726  13.113  11.352  1.00 90.50           O  \\nATOM   1739  CG  HIS A 218     -14.121  13.401  15.641  1.00 90.50           C  \\nATOM   1740  CD2 HIS A 218     -14.893  12.492  16.313  1.00 90.50           C  \\nATOM   1741  ND1 HIS A 218     -13.159  13.839  16.527  1.00 90.50           N  \\nATOM   1742  CE1 HIS A 218     -13.342  13.196  17.691  1.00 90.50           C  \\nATOM   1743  NE2 HIS A 218     -14.401  12.380  17.615  1.00 90.50           N  \\nATOM   1744  N   GLN A 219     -12.867  14.302  10.991  1.00 93.33           N  \\nATOM   1745  CA  GLN A 219     -13.011  14.418   9.535  1.00 93.33           C  \\nATOM   1746  C   GLN A 219     -12.255  13.313   8.771  1.00 93.33           C  \\nATOM   1747  CB  GLN A 219     -12.543  15.812   9.082  1.00 93.33           C  \\nATOM   1748  O   GLN A 219     -12.288  13.290   7.539  1.00 93.33           O  \\nATOM   1749  CG  GLN A 219     -13.286  16.979   9.748  1.00 93.33           C  \\nATOM   1750  CD  GLN A 219     -14.760  17.025   9.367  1.00 93.33           C  \\nATOM   1751  NE2 GLN A 219     -15.656  16.532  10.192  1.00 93.33           N  \\nATOM   1752  OE1 GLN A 219     -15.139  17.517   8.321  1.00 93.33           O  \\nATOM   1753  N   CYS A 220     -11.541  12.413   9.462  1.00 95.56           N  \\nATOM   1754  CA  CYS A 220     -10.745  11.366   8.825  1.00 95.56           C  \\nATOM   1755  C   CYS A 220     -11.609  10.201   8.335  1.00 95.56           C  \\nATOM   1756  CB  CYS A 220      -9.612  10.912   9.743  1.00 95.56           C  \\nATOM   1757  O   CYS A 220     -11.838   9.225   9.044  1.00 95.56           O  \\nATOM   1758  SG  CYS A 220      -8.577   9.726   8.840  1.00 95.56           S  \\nATOM   1759  N   GLU A 221     -12.046  10.283   7.085  1.00 96.16           N  \\nATOM   1760  CA  GLU A 221     -12.952   9.303   6.478  1.00 96.16           C  \\nATOM   1761  C   GLU A 221     -12.312   8.494   5.347  1.00 96.16           C  \\nATOM   1762  CB  GLU A 221     -14.236  10.005   6.041  1.00 96.16           C  \\nATOM   1763  O   GLU A 221     -13.010   7.766   4.641  1.00 96.16           O  \\nATOM   1764  CG  GLU A 221     -15.003  10.589   7.239  1.00 96.16           C  \\nATOM   1765  CD  GLU A 221     -16.401  11.044   6.825  1.00 96.16           C  \\nATOM   1766  OE1 GLU A 221     -17.332  11.017   7.664  1.00 96.16           O  \\nATOM   1767  OE2 GLU A 221     -16.582  11.339   5.625  1.00 96.16           O  \\nATOM   1768  N   VAL A 222     -10.988   8.598   5.191  1.00 98.08           N  \\nATOM   1769  CA  VAL A 222     -10.179   7.778   4.282  1.00 98.08           C  \\nATOM   1770  C   VAL A 222      -8.957   7.254   5.028  1.00 98.08           C  \\nATOM   1771  CB  VAL A 222      -9.741   8.570   3.036  1.00 98.08           C  \\nATOM   1772  O   VAL A 222      -8.245   8.020   5.680  1.00 98.08           O  \\nATOM   1773  CG1 VAL A 222      -8.985   7.695   2.027  1.00 98.08           C  \\nATOM   1774  CG2 VAL A 222     -10.920   9.198   2.289  1.00 98.08           C  \\nATOM   1775  N   GLY A 223      -8.691   5.956   4.904  1.00 97.90           N  \\nATOM   1776  CA  GLY A 223      -7.450   5.327   5.349  1.00 97.90           C  \\nATOM   1777  C   GLY A 223      -6.646   4.835   4.160  1.00 97.90           C  \\nATOM   1778  O   GLY A 223      -7.185   4.162   3.286  1.00 97.90           O  \\nATOM   1779  N   MET A 224      -5.355   5.148   4.120  1.00 97.88           N  \\nATOM   1780  CA  MET A 224      -4.455   4.743   3.047  1.00 97.88           C  \\nATOM   1781  C   MET A 224      -3.206   4.066   3.583  1.00 97.88           C  \\nATOM   1782  CB  MET A 224      -4.024   5.946   2.210  1.00 97.88           C  \\nATOM   1783  O   MET A 224      -2.588   4.532   4.539  1.00 97.88           O  \\nATOM   1784  CG  MET A 224      -5.168   6.554   1.405  1.00 97.88           C  \\nATOM   1785  SD  MET A 224      -4.592   7.772   0.198  1.00 97.88           S  \\nATOM   1786  CE  MET A 224      -3.627   6.723  -0.910  1.00 97.88           C  \\nATOM   1787  N   ILE A 225      -2.779   3.027   2.874  1.00 96.64           N  \\nATOM   1788  CA  ILE A 225      -1.469   2.412   3.048  1.00 96.64           C  \\nATOM   1789  C   ILE A 225      -0.663   2.655   1.778  1.00 96.64           C  \\nATOM   1790  CB  ILE A 225      -1.604   0.915   3.384  1.00 96.64           C  \\nATOM   1791  O   ILE A 225      -1.080   2.260   0.692  1.00 96.64           O  \\nATOM   1792  CG1 ILE A 225      -2.465   0.671   4.641  1.00 96.64           C  \\nATOM   1793  CG2 ILE A 225      -0.216   0.266   3.543  1.00 96.64           C  \\nATOM   1794  CD1 ILE A 225      -1.953   1.277   5.950  1.00 96.64           C  \\nATOM   1795  N   VAL A 226       0.503   3.285   1.910  1.00 97.26           N  \\nATOM   1796  CA  VAL A 226       1.485   3.474   0.834  1.00 97.26           C  \\nATOM   1797  C   VAL A 226       2.853   3.040   1.363  1.00 97.26           C  \\nATOM   1798  CB  VAL A 226       1.483   4.918   0.303  1.00 97.26           C  \\nATOM   1799  O   VAL A 226       3.667   3.832   1.845  1.00 97.26           O  \\nATOM   1800  CG1 VAL A 226       2.283   4.996  -1.001  1.00 97.26           C  \\nATOM   1801  CG2 VAL A 226       0.083   5.479   0.020  1.00 97.26           C  \\nATOM   1802  N   GLY A 227       3.075   1.728   1.356  1.00 94.28           N  \\nATOM   1803  CA  GLY A 227       4.227   1.063   1.964  1.00 94.28           C  \\nATOM   1804  C   GLY A 227       4.749  -0.043   1.063  1.00 94.28           C  \\nATOM   1805  O   GLY A 227       5.016   0.200  -0.107  1.00 94.28           O  \\nATOM   1806  N   THR A 228       4.883  -1.266   1.586  1.00 91.11           N  \\nATOM   1807  CA  THR A 228       5.219  -2.451   0.773  1.00 91.11           C  \\nATOM   1808  C   THR A 228       4.225  -2.634  -0.380  1.00 91.11           C  \\nATOM   1809  CB  THR A 228       5.240  -3.711   1.657  1.00 91.11           C  \\nATOM   1810  O   THR A 228       4.643  -2.866  -1.511  1.00 91.11           O  \\nATOM   1811  CG2 THR A 228       5.673  -4.979   0.928  1.00 91.11           C  \\nATOM   1812  OG1 THR A 228       6.155  -3.512   2.709  1.00 91.11           O  \\nATOM   1813  N   GLY A 229       2.934  -2.474  -0.085  1.00 93.07           N  \\nATOM   1814  CA  GLY A 229       1.842  -2.415  -1.056  1.00 93.07           C  \\nATOM   1815  C   GLY A 229       1.159  -1.046  -1.071  1.00 93.07           C  \\nATOM   1816  O   GLY A 229       1.620  -0.115  -0.401  1.00 93.07           O  \\nATOM   1817  N   CYS A 230       0.052  -0.933  -1.804  1.00 95.59           N  \\nATOM   1818  CA  CYS A 230      -0.761   0.279  -1.845  1.00 95.59           C  \\nATOM   1819  C   CYS A 230      -2.255  -0.053  -1.846  1.00 95.59           C  \\nATOM   1820  CB  CYS A 230      -0.364   1.150  -3.043  1.00 95.59           C  \\nATOM   1821  O   CYS A 230      -2.741  -0.684  -2.779  1.00 95.59           O  \\nATOM   1822  SG  CYS A 230      -1.239   2.739  -2.931  1.00 95.59           S  \\nATOM   1823  N   ASN A 231      -2.984   0.405  -0.827  1.00 97.28           N  \\nATOM   1824  CA  ASN A 231      -4.427   0.193  -0.698  1.00 97.28           C  \\nATOM   1825  C   ASN A 231      -5.110   1.403  -0.035  1.00 97.28           C  \\nATOM   1826  CB  ASN A 231      -4.701  -1.132   0.034  1.00 97.28           C  \\nATOM   1827  O   ASN A 231      -4.439   2.213   0.616  1.00 97.28           O  \\nATOM   1828  CG  ASN A 231      -6.149  -1.574  -0.121  1.00 97.28           C  \\nATOM   1829  ND2 ASN A 231      -6.643  -2.362   0.796  1.00 97.28           N  \\nATOM   1830  OD1 ASN A 231      -6.848  -1.176  -1.043  1.00 97.28           O  \\nATOM   1831  N   ALA A 232      -6.430   1.510  -0.174  1.00 98.35           N  \\nATOM   1832  CA  ALA A 232      -7.242   2.478   0.549  1.00 98.35           C  \\nATOM   1833  C   ALA A 232      -8.595   1.910   0.992  1.00 98.35           C  \\nATOM   1834  CB  ALA A 232      -7.432   3.728  -0.313  1.00 98.35           C  \\nATOM   1835  O   ALA A 232      -9.159   1.021   0.356  1.00 98.35           O  \\nATOM   1836  N   CYS A 233      -9.145   2.496   2.048  1.00 98.12           N  \\nATOM   1837  CA  CYS A 233     -10.540   2.367   2.446  1.00 98.12           C  \\nATOM   1838  C   CYS A 233     -11.151   3.753   2.665  1.00 98.12           C  \\nATOM   1839  CB  CYS A 233     -10.651   1.506   3.711  1.00 98.12           C  \\nATOM   1840  O   CYS A 233     -10.427   4.731   2.863  1.00 98.12           O  \\nATOM   1841  SG  CYS A 233     -10.082   2.442   5.159  1.00 98.12           S  \\nATOM   1842  N   TYR A 234     -12.476   3.836   2.691  1.00 98.06           N  \\nATOM   1843  CA  TYR A 234     -13.186   5.069   3.034  1.00 98.06           C  \\nATOM   1844  C   TYR A 234     -14.588   4.784   3.578  1.00 98.06           C  \\nATOM   1845  CB  TYR A 234     -13.247   5.999   1.812  1.00 98.06           C  \\nATOM   1846  O   TYR A 234     -15.077   3.659   3.474  1.00 98.06           O  \\nATOM   1847  CG  TYR A 234     -14.151   5.509   0.703  1.00 98.06           C  \\nATOM   1848  CD1 TYR A 234     -13.730   4.458  -0.131  1.00 98.06           C  \\nATOM   1849  CD2 TYR A 234     -15.424   6.082   0.528  1.00 98.06           C  \\nATOM   1850  CE1 TYR A 234     -14.593   3.967  -1.123  1.00 98.06           C  \\nATOM   1851  CE2 TYR A 234     -16.279   5.613  -0.484  1.00 98.06           C  \\nATOM   1852  OH  TYR A 234     -16.693   4.055  -2.257  1.00 98.06           O  \\nATOM   1853  CZ  TYR A 234     -15.867   4.542  -1.302  1.00 98.06           C  \\nATOM   1854  N   MET A 235     -15.232   5.789   4.175  1.00 96.17           N  \\nATOM   1855  CA  MET A 235     -16.636   5.710   4.598  1.00 96.17           C  \\nATOM   1856  C   MET A 235     -17.583   5.975   3.419  1.00 96.17           C  \\nATOM   1857  CB  MET A 235     -16.906   6.698   5.743  1.00 96.17           C  \\nATOM   1858  O   MET A 235     -17.682   7.110   2.948  1.00 96.17           O  \\nATOM   1859  CG  MET A 235     -16.178   6.334   7.043  1.00 96.17           C  \\nATOM   1860  SD  MET A 235     -16.573   4.712   7.770  1.00 96.17           S  \\nATOM   1861  CE  MET A 235     -18.368   4.828   7.984  1.00 96.17           C  \\nATOM   1862  N   GLU A 236     -18.297   4.940   2.980  1.00 96.33           N  \\nATOM   1863  CA  GLU A 236     -19.298   4.995   1.907  1.00 96.33           C  \\nATOM   1864  C   GLU A 236     -20.724   5.034   2.481  1.00 96.33           C  \\nATOM   1865  CB  GLU A 236     -19.079   3.796   0.963  1.00 96.33           C  \\nATOM   1866  O   GLU A 236     -20.992   4.499   3.563  1.00 96.33           O  \\nATOM   1867  CG  GLU A 236     -19.969   3.743  -0.291  1.00 96.33           C  \\nATOM   1868  CD  GLU A 236     -19.869   4.986  -1.189  1.00 96.33           C  \\nATOM   1869  OE1 GLU A 236     -20.601   5.970  -0.937  1.00 96.33           O  \\nATOM   1870  OE2 GLU A 236     -19.076   4.962  -2.163  1.00 96.33           O  \\nATOM   1871  N   GLU A 237     -21.640   5.665   1.746  1.00 95.22           N  \\nATOM   1872  CA  GLU A 237     -23.070   5.679   2.067  1.00 95.22           C  \\nATOM   1873  C   GLU A 237     -23.685   4.302   1.782  1.00 95.22           C  \\nATOM   1874  CB  GLU A 237     -23.800   6.773   1.269  1.00 95.22           C  \\nATOM   1875  O   GLU A 237     -23.511   3.756   0.692  1.00 95.22           O  \\nATOM   1876  CG  GLU A 237     -23.233   8.195   1.431  1.00 95.22           C  \\nATOM   1877  CD  GLU A 237     -23.203   8.685   2.888  1.00 95.22           C  \\nATOM   1878  OE1 GLU A 237     -22.242   9.414   3.243  1.00 95.22           O  \\nATOM   1879  OE2 GLU A 237     -24.106   8.305   3.668  1.00 95.22           O  \\nATOM   1880  N   MET A 238     -24.431   3.734   2.735  1.00 94.83           N  \\nATOM   1881  CA  MET A 238     -24.968   2.368   2.617  1.00 94.83           C  \\nATOM   1882  C   MET A 238     -25.888   2.181   1.407  1.00 94.83           C  \\nATOM   1883  CB  MET A 238     -25.717   1.985   3.898  1.00 94.83           C  \\nATOM   1884  O   MET A 238     -25.868   1.120   0.794  1.00 94.83           O  \\nATOM   1885  CG  MET A 238     -24.775   1.519   5.010  1.00 94.83           C  \\nATOM   1886  SD  MET A 238     -23.848  -0.010   4.697  1.00 94.83           S  \\nATOM   1887  CE  MET A 238     -25.178  -1.162   4.262  1.00 94.83           C  \\nATOM   1888  N   GLN A 239     -26.612   3.225   0.993  1.00 95.01           N  \\nATOM   1889  CA  GLN A 239     -27.411   3.222  -0.239  1.00 95.01           C  \\nATOM   1890  C   GLN A 239     -26.606   2.885  -1.513  1.00 95.01           C  \\nATOM   1891  CB  GLN A 239     -28.106   4.587  -0.390  1.00 95.01           C  \\nATOM   1892  O   GLN A 239     -27.194   2.500  -2.519  1.00 95.01           O  \\nATOM   1893  CG  GLN A 239     -27.111   5.742  -0.602  1.00 95.01           C  \\nATOM   1894  CD  GLN A 239     -27.787   7.080  -0.863  1.00 95.01           C  \\nATOM   1895  NE2 GLN A 239     -27.333   7.815  -1.855  1.00 95.01           N  \\nATOM   1896  OE1 GLN A 239     -28.713   7.502  -0.191  1.00 95.01           O  \\nATOM   1897  N   ASN A 240     -25.277   3.044  -1.486  1.00 95.87           N  \\nATOM   1898  CA  ASN A 240     -24.388   2.727  -2.602  1.00 95.87           C  \\nATOM   1899  C   ASN A 240     -23.775   1.318  -2.492  1.00 95.87           C  \\nATOM   1900  CB  ASN A 240     -23.276   3.792  -2.680  1.00 95.87           C  \\nATOM   1901  O   ASN A 240     -23.098   0.898  -3.424  1.00 95.87           O  \\nATOM   1902  CG  ASN A 240     -23.768   5.212  -2.893  1.00 95.87           C  \\nATOM   1903  ND2 ASN A 240     -23.052   6.188  -2.386  1.00 95.87           N  \\nATOM   1904  OD1 ASN A 240     -24.770   5.487  -3.534  1.00 95.87           O  \\nATOM   1905  N   VAL A 241     -23.950   0.607  -1.370  1.00 95.90           N  \\nATOM   1906  CA  VAL A 241     -23.299  -0.683  -1.084  1.00 95.90           C  \\nATOM   1907  C   VAL A 241     -24.302  -1.825  -1.267  1.00 95.90           C  \\nATOM   1908  CB  VAL A 241     -22.658  -0.701   0.326  1.00 95.90           C  \\nATOM   1909  O   VAL A 241     -24.852  -2.346  -0.303  1.00 95.90           O  \\nATOM   1910  CG1 VAL A 241     -21.804  -1.966   0.527  1.00 95.90           C  \\nATOM   1911  CG2 VAL A 241     -21.739   0.503   0.585  1.00 95.90           C  \\nATOM   1912  N   GLU A 242     -24.513  -2.271  -2.507  1.00 96.47           N  \\nATOM   1913  CA  GLU A 242     -25.487  -3.338  -2.819  1.00 96.47           C  \\nATOM   1914  C   GLU A 242     -25.071  -4.729  -2.298  1.00 96.47           C  \\nATOM   1915  CB  GLU A 242     -25.709  -3.423  -4.335  1.00 96.47           C  \\nATOM   1916  O   GLU A 242     -25.857  -5.674  -2.317  1.00 96.47           O  \\nATOM   1917  CG  GLU A 242     -26.308  -2.156  -4.969  1.00 96.47           C  \\nATOM   1918  CD  GLU A 242     -26.504  -2.300  -6.490  1.00 96.47           C  \\nATOM   1919  OE1 GLU A 242     -26.937  -1.310  -7.124  1.00 96.47           O  \\nATOM   1920  OE2 GLU A 242     -26.171  -3.379  -7.043  1.00 96.47           O  \\nATOM   1921  N   LEU A 243     -23.824  -4.869  -1.838  1.00 93.58           N  \\nATOM   1922  CA  LEU A 243     -23.253  -6.121  -1.331  1.00 93.58           C  \\nATOM   1923  C   LEU A 243     -23.720  -6.488   0.084  1.00 93.58           C  \\nATOM   1924  CB  LEU A 243     -21.722  -6.002  -1.341  1.00 93.58           C  \\nATOM   1925  O   LEU A 243     -23.450  -7.597   0.547  1.00 93.58           O  \\nATOM   1926  CG  LEU A 243     -21.099  -5.677  -2.705  1.00 93.58           C  \\nATOM   1927  CD1 LEU A 243     -19.595  -5.517  -2.512  1.00 93.58           C  \\nATOM   1928  CD2 LEU A 243     -21.372  -6.768  -3.741  1.00 93.58           C  \\nATOM   1929  N   VAL A 244     -24.358  -5.557   0.795  1.00 92.30           N  \\nATOM   1930  CA  VAL A 244     -24.839  -5.748   2.166  1.00 92.30           C  \\nATOM   1931  C   VAL A 244     -26.299  -5.324   2.235  1.00 92.30           C  \\nATOM   1932  CB  VAL A 244     -23.983  -4.964   3.179  1.00 92.30           C  \\nATOM   1933  O   VAL A 244     -26.692  -4.325   1.646  1.00 92.30           O  \\nATOM   1934  CG1 VAL A 244     -24.454  -5.193   4.623  1.00 92.30           C  \\nATOM   1935  CG2 VAL A 244     -22.508  -5.382   3.119  1.00 92.30           C  \\nATOM   1936  N   GLU A 245     -27.113  -6.071   2.979  1.00 91.11           N  \\nATOM   1937  CA  GLU A 245     -28.515  -5.709   3.176  1.00 91.11           C  \\nATOM   1938  C   GLU A 245     -28.671  -4.416   4.002  1.00 91.11           C  \\nATOM   1939  CB  GLU A 245     -29.300  -6.868   3.812  1.00 91.11           C  \\nATOM   1940  O   GLU A 245     -28.004  -4.203   5.026  1.00 91.11           O  \\nATOM   1941  CG  GLU A 245     -29.395  -8.107   2.901  1.00 91.11           C  \\nATOM   1942  CD  GLU A 245     -30.291  -9.222   3.476  1.00 91.11           C  \\nATOM   1943  OE1 GLU A 245     -30.542 -10.202   2.737  1.00 91.11           O  \\nATOM   1944  OE2 GLU A 245     -30.728  -9.105   4.645  1.00 91.11           O  \\nATOM   1945  N   GLY A 246     -29.621  -3.583   3.568  1.00 91.34           N  \\nATOM   1946  CA  GLY A 246     -29.977  -2.304   4.185  1.00 91.34           C  \\nATOM   1947  C   GLY A 246     -29.236  -1.106   3.587  1.00 91.34           C  \\nATOM   1948  O   GLY A 246     -28.090  -1.208   3.172  1.00 91.34           O  \\nATOM   1949  N   ASP A 247     -29.897   0.047   3.583  1.00 91.55           N  \\nATOM   1950  CA  ASP A 247     -29.433   1.309   2.991  1.00 91.55           C  \\nATOM   1951  C   ASP A 247     -29.157   2.407   4.038  1.00 91.55           C  \\nATOM   1952  CB  ASP A 247     -30.459   1.764   1.936  1.00 91.55           C  \\nATOM   1953  O   ASP A 247     -28.713   3.503   3.696  1.00 91.55           O  \\nATOM   1954  CG  ASP A 247     -31.891   1.961   2.465  1.00 91.55           C  \\nATOM   1955  OD1 ASP A 247     -32.155   1.604   3.639  1.00 91.55           O  \\nATOM   1956  OD2 ASP A 247     -32.740   2.406   1.662  1.00 91.55           O  \\nATOM   1957  N   GLU A 248     -29.372   2.116   5.325  1.00 91.74           N  \\nATOM   1958  CA  GLU A 248     -29.239   3.094   6.405  1.00 91.74           C  \\nATOM   1959  C   GLU A 248     -27.797   3.289   6.895  1.00 91.74           C  \\nATOM   1960  CB  GLU A 248     -30.131   2.738   7.602  1.00 91.74           C  \\nATOM   1961  O   GLU A 248     -27.109   2.355   7.329  1.00 91.74           O  \\nATOM   1962  CG  GLU A 248     -31.636   2.827   7.303  1.00 91.74           C  \\nATOM   1963  CD  GLU A 248     -32.502   2.697   8.570  1.00 91.74           C  \\nATOM   1964  OE1 GLU A 248     -33.730   2.924   8.469  1.00 91.74           O  \\nATOM   1965  OE2 GLU A 248     -31.945   2.396   9.654  1.00 91.74           O  \\nATOM   1966  N   GLY A 249     -27.385   4.556   6.945  1.00 92.95           N  \\nATOM   1967  CA  GLY A 249     -26.119   4.985   7.525  1.00 92.95           C  \\nATOM   1968  C   GLY A 249     -24.937   4.790   6.581  1.00 92.95           C  \\nATOM   1969  O   GLY A 249     -25.057   4.897   5.364  1.00 92.95           O  \\nATOM   1970  N   ARG A 250     -23.762   4.542   7.163  1.00 93.49           N  \\nATOM   1971  CA  ARG A 250     -22.491   4.471   6.435  1.00 93.49           C  \\nATOM   1972  C   ARG A 250     -21.715   3.228   6.832  1.00 93.49           C  \\nATOM   1973  CB  ARG A 250     -21.678   5.759   6.655  1.00 93.49           C  \\nATOM   1974  O   ARG A 250     -21.830   2.748   7.962  1.00 93.49           O  \\nATOM   1975  CG  ARG A 250     -22.411   6.992   6.098  1.00 93.49           C  \\nATOM   1976  CD  ARG A 250     -21.650   8.301   6.306  1.00 93.49           C  \\nATOM   1977  NE  ARG A 250     -21.483   8.639   7.739  1.00 93.49           N  \\nATOM   1978  NH1 ARG A 250     -19.907  10.250   7.401  1.00 93.49           N  \\nATOM   1979  NH2 ARG A 250     -20.436   9.685   9.486  1.00 93.49           N  \\nATOM   1980  CZ  ARG A 250     -20.619   9.522   8.207  1.00 93.49           C  \\nATOM   1981  N   MET A 251     -20.891   2.732   5.921  1.00 94.49           N  \\nATOM   1982  CA  MET A 251     -19.983   1.622   6.183  1.00 94.49           C  \\nATOM   1983  C   MET A 251     -18.611   1.921   5.598  1.00 94.49           C  \\nATOM   1984  CB  MET A 251     -20.580   0.315   5.644  1.00 94.49           C  \\nATOM   1985  O   MET A 251     -18.487   2.467   4.505  1.00 94.49           O  \\nATOM   1986  CG  MET A 251     -19.678  -0.891   5.927  1.00 94.49           C  \\nATOM   1987  SD  MET A 251     -20.291  -2.505   5.388  1.00 94.49           S  \\nATOM   1988  CE  MET A 251     -21.765  -2.695   6.410  1.00 94.49           C  \\nATOM   1989  N   CYS A 252     -17.566   1.542   6.329  1.00 95.98           N  \\nATOM   1990  CA  CYS A 252     -16.228   1.557   5.773  1.00 95.98           C  \\nATOM   1991  C   CYS A 252     -16.102   0.474   4.694  1.00 95.98           C  \\nATOM   1992  CB  CYS A 252     -15.199   1.412   6.892  1.00 95.98           C  \\nATOM   1993  O   CYS A 252     -16.375  -0.706   4.940  1.00 95.98           O  \\nATOM   1994  SG  CYS A 252     -13.547   1.624   6.181  1.00 95.98           S  \\nATOM   1995  N   VAL A 253     -15.669   0.875   3.506  1.00 97.54           N  \\nATOM   1996  CA  VAL A 253     -15.423  -0.009   2.371  1.00 97.54           C  \\nATOM   1997  C   VAL A 253     -13.928  -0.042   2.100  1.00 97.54           C  \\nATOM   1998  CB  VAL A 253     -16.227   0.445   1.142  1.00 97.54           C  \\nATOM   1999  O   VAL A 253     -13.291   1.000   1.945  1.00 97.54           O  \\nATOM   2000  CG1 VAL A 253     -15.889  -0.419  -0.074  1.00 97.54           C  \\nATOM   2001  CG2 VAL A 253     -17.732   0.309   1.410  1.00 97.54           C  \\nATOM   2002  N   ASN A 254     -13.367  -1.245   2.043  1.00 97.72           N  \\nATOM   2003  CA  ASN A 254     -11.996  -1.473   1.616  1.00 97.72           C  \\nATOM   2004  C   ASN A 254     -11.971  -1.602   0.090  1.00 97.72           C  \\nATOM   2005  CB  ASN A 254     -11.473  -2.717   2.342  1.00 97.72           C  \\nATOM   2006  O   ASN A 254     -12.585  -2.506  -0.470  1.00 97.72           O  \\nATOM   2007  CG  ASN A 254     -10.074  -3.102   1.914  1.00 97.72           C  \\nATOM   2008  ND2 ASN A 254      -9.595  -4.198   2.439  1.00 97.72           N  \\nATOM   2009  OD1 ASN A 254      -9.419  -2.448   1.117  1.00 97.72           O  \\nATOM   2010  N   THR A 255     -11.278  -0.697  -0.595  1.00 98.21           N  \\nATOM   2011  CA  THR A 255     -11.315  -0.648  -2.062  1.00 98.21           C  \\nATOM   2012  C   THR A 255     -10.654  -1.868  -2.701  1.00 98.21           C  \\nATOM   2013  CB  THR A 255     -10.670   0.634  -2.611  1.00 98.21           C  \\nATOM   2014  O   THR A 255     -11.110  -2.319  -3.752  1.00 98.21           O  \\nATOM   2015  CG2 THR A 255     -11.329   1.906  -2.072  1.00 98.21           C  \\nATOM   2016  OG1 THR A 255      -9.298   0.695  -2.295  1.00 98.21           O  \\nATOM   2017  N   GLU A 256      -9.601  -2.405  -2.072  1.00 96.76           N  \\nATOM   2018  CA  GLU A 256      -8.670  -3.360  -2.688  1.00 96.76           C  \\nATOM   2019  C   GLU A 256      -8.231  -2.903  -4.091  1.00 96.76           C  \\nATOM   2020  CB  GLU A 256      -9.217  -4.798  -2.634  1.00 96.76           C  \\nATOM   2021  O   GLU A 256      -8.126  -3.687  -5.035  1.00 96.76           O  \\nATOM   2022  CG  GLU A 256      -9.296  -5.369  -1.209  1.00 96.76           C  \\nATOM   2023  CD  GLU A 256      -7.940  -5.459  -0.484  1.00 96.76           C  \\nATOM   2024  OE1 GLU A 256      -7.940  -5.511   0.769  1.00 96.76           O  \\nATOM   2025  OE2 GLU A 256      -6.891  -5.515  -1.160  1.00 96.76           O  \\nATOM   2026  N   TRP A 257      -7.966  -1.599  -4.243  1.00 97.81           N  \\nATOM   2027  CA  TRP A 257      -7.658  -0.981  -5.536  1.00 97.81           C  \\nATOM   2028  C   TRP A 257      -6.321  -1.426  -6.142  1.00 97.81           C  \\nATOM   2029  CB  TRP A 257      -7.731   0.544  -5.403  1.00 97.81           C  \\nATOM   2030  O   TRP A 257      -5.963  -0.993  -7.234  1.00 97.81           O  \\nATOM   2031  CG  TRP A 257      -6.690   1.240  -4.568  1.00 97.81           C  \\nATOM   2032  CD1 TRP A 257      -5.538   0.722  -4.075  1.00 97.81           C  \\nATOM   2033  CD2 TRP A 257      -6.690   2.632  -4.131  1.00 97.81           C  \\nATOM   2034  CE2 TRP A 257      -5.485   2.880  -3.410  1.00 97.81           C  \\nATOM   2035  CE3 TRP A 257      -7.573   3.721  -4.278  1.00 97.81           C  \\nATOM   2036  NE1 TRP A 257      -4.802   1.699  -3.456  1.00 97.81           N  \\nATOM   2037  CH2 TRP A 257      -6.069   5.181  -3.014  1.00 97.81           C  \\nATOM   2038  CZ2 TRP A 257      -5.161   4.121  -2.866  1.00 97.81           C  \\nATOM   2039  CZ3 TRP A 257      -7.265   4.977  -3.721  1.00 97.81           C  \\nATOM   2040  N   GLY A 258      -5.555  -2.270  -5.441  1.00 96.80           N  \\nATOM   2041  CA  GLY A 258      -4.263  -2.761  -5.907  1.00 96.80           C  \\nATOM   2042  C   GLY A 258      -4.404  -3.567  -7.197  1.00 96.80           C  \\nATOM   2043  O   GLY A 258      -3.517  -3.498  -8.046  1.00 96.80           O  \\nATOM   2044  N   ALA A 259      -5.551  -4.235  -7.369  1.00 96.71           N  \\nATOM   2045  CA  ALA A 259      -5.952  -4.993  -8.555  1.00 96.71           C  \\nATOM   2046  C   ALA A 259      -6.477  -4.122  -9.712  1.00 96.71           C  \\nATOM   2047  CB  ALA A 259      -6.992  -6.021  -8.097  1.00 96.71           C  \\nATOM   2048  O   ALA A 259      -6.822  -4.633 -10.775  1.00 96.71           O  \\nATOM   2049  N   PHE A 260      -6.553  -2.798  -9.549  1.00 98.45           N  \\nATOM   2050  CA  PHE A 260      -6.910  -1.921 -10.658  1.00 98.45           C  \\nATOM   2051  C   PHE A 260      -5.923  -2.093 -11.826  1.00 98.45           C  \\nATOM   2052  CB  PHE A 260      -6.998  -0.480 -10.157  1.00 98.45           C  \\nATOM   2053  O   PHE A 260      -4.708  -2.102 -11.634  1.00 98.45           O  \\nATOM   2054  CG  PHE A 260      -7.327   0.533 -11.226  1.00 98.45           C  \\nATOM   2055  CD1 PHE A 260      -6.460   1.617 -11.433  1.00 98.45           C  \\nATOM   2056  CD2 PHE A 260      -8.499   0.415 -11.996  1.00 98.45           C  \\nATOM   2057  CE1 PHE A 260      -6.770   2.582 -12.398  1.00 98.45           C  \\nATOM   2058  CE2 PHE A 260      -8.793   1.371 -12.981  1.00 98.45           C  \\nATOM   2059  CZ  PHE A 260      -7.920   2.451 -13.188  1.00 98.45           C  \\nATOM   2060  N   GLY A 261      -6.442  -2.251 -13.043  1.00 97.78           N  \\nATOM   2061  CA  GLY A 261      -5.640  -2.551 -14.229  1.00 97.78           C  \\nATOM   2062  C   GLY A 261      -5.601  -4.029 -14.606  1.00 97.78           C  \\nATOM   2063  O   GLY A 261      -5.274  -4.316 -15.756  1.00 97.78           O  \\nATOM   2064  N   ASP A 262      -5.965  -4.950 -13.705  1.00 96.60           N  \\nATOM   2065  CA  ASP A 262      -5.951  -6.397 -13.967  1.00 96.60           C  \\nATOM   2066  C   ASP A 262      -6.902  -6.796 -15.121  1.00 96.60           C  \\nATOM   2067  CB  ASP A 262      -6.297  -7.176 -12.676  1.00 96.60           C  \\nATOM   2068  O   ASP A 262      -6.708  -7.839 -15.744  1.00 96.60           O  \\nATOM   2069  CG  ASP A 262      -5.263  -7.084 -11.532  1.00 96.60           C  \\nATOM   2070  OD1 ASP A 262      -4.224  -6.389 -11.650  1.00 96.60           O  \\nATOM   2071  OD2 ASP A 262      -5.468  -7.737 -10.479  1.00 96.60           O  \\nATOM   2072  N   SER A 263      -7.896  -5.957 -15.459  1.00 96.14           N  \\nATOM   2073  CA  SER A 263      -8.797  -6.155 -16.610  1.00 96.14           C  \\nATOM   2074  C   SER A 263      -8.514  -5.191 -17.776  1.00 96.14           C  \\nATOM   2075  CB  SER A 263     -10.268  -6.125 -16.185  1.00 96.14           C  \\nATOM   2076  O   SER A 263      -9.381  -4.951 -18.621  1.00 96.14           O  \\nATOM   2077  OG  SER A 263     -10.502  -7.039 -15.134  1.00 96.14           O  \\nATOM   2078  N   GLY A 264      -7.296  -4.643 -17.851  1.00 97.16           N  \\nATOM   2079  CA  GLY A 264      -6.818  -3.802 -18.956  1.00 97.16           C  \\nATOM   2080  C   GLY A 264      -7.079  -2.302 -18.785  1.00 97.16           C  \\nATOM   2081  O   GLY A 264      -6.789  -1.509 -19.683  1.00 97.16           O  \\nATOM   2082  N   GLU A 265      -7.583  -1.853 -17.630  1.00 98.06           N  \\nATOM   2083  CA  GLU A 265      -7.887  -0.436 -17.378  1.00 98.06           C  \\nATOM   2084  C   GLU A 265      -6.649   0.467 -17.447  1.00 98.06           C  \\nATOM   2085  CB  GLU A 265      -8.536  -0.229 -16.001  1.00 98.06           C  \\nATOM   2086  O   GLU A 265      -6.768   1.675 -17.686  1.00 98.06           O  \\nATOM   2087  CG  GLU A 265      -9.840  -1.006 -15.787  1.00 98.06           C  \\nATOM   2088  CD  GLU A 265      -9.653  -2.440 -15.266  1.00 98.06           C  \\nATOM   2089  OE1 GLU A 265     -10.686  -3.038 -14.924  1.00 98.06           O  \\nATOM   2090  OE2 GLU A 265      -8.503  -2.945 -15.240  1.00 98.06           O  \\nATOM   2091  N   LEU A 266      -5.466  -0.114 -17.240  1.00 97.86           N  \\nATOM   2092  CA  LEU A 266      -4.183   0.579 -17.202  1.00 97.86           C  \\nATOM   2093  C   LEU A 266      -3.289   0.299 -18.413  1.00 97.86           C  \\nATOM   2094  CB  LEU A 266      -3.471   0.252 -15.876  1.00 97.86           C  \\nATOM   2095  O   LEU A 266      -2.186   0.836 -18.452  1.00 97.86           O  \\nATOM   2096  CG  LEU A 266      -4.158   0.841 -14.632  1.00 97.86           C  \\nATOM   2097  CD1 LEU A 266      -3.342   0.483 -13.395  1.00 97.86           C  \\nATOM   2098  CD2 LEU A 266      -4.250   2.369 -14.718  1.00 97.86           C  \\nATOM   2099  N   ASP A 267      -3.738  -0.468 -19.413  1.00 98.02           N  \\nATOM   2100  CA  ASP A 267      -2.878  -0.949 -20.507  1.00 98.02           C  \\nATOM   2101  C   ASP A 267      -2.108   0.159 -21.240  1.00 98.02           C  \\nATOM   2102  CB  ASP A 267      -3.721  -1.728 -21.535  1.00 98.02           C  \\nATOM   2103  O   ASP A 267      -0.954  -0.051 -21.616  1.00 98.02           O  \\nATOM   2104  CG  ASP A 267      -3.889  -3.213 -21.209  1.00 98.02           C  \\nATOM   2105  OD1 ASP A 267      -3.043  -3.739 -20.450  1.00 98.02           O  \\nATOM   2106  OD2 ASP A 267      -4.796  -3.822 -21.812  1.00 98.02           O  \\nATOM   2107  N   GLU A 268      -2.713   1.342 -21.409  1.00 97.04           N  \\nATOM   2108  CA  GLU A 268      -2.069   2.492 -22.068  1.00 97.04           C  \\nATOM   2109  C   GLU A 268      -0.940   3.131 -21.235  1.00 97.04           C  \\nATOM   2110  CB  GLU A 268      -3.121   3.541 -22.513  1.00 97.04           C  \\nATOM   2111  O   GLU A 268      -0.135   3.877 -21.783  1.00 97.04           O  \\nATOM   2112  CG  GLU A 268      -3.566   4.502 -21.396  1.00 97.04           C  \\nATOM   2113  CD  GLU A 268      -4.639   5.536 -21.801  1.00 97.04           C  \\nATOM   2114  OE1 GLU A 268      -5.689   5.561 -21.126  1.00 97.04           O  \\nATOM   2115  OE2 GLU A 268      -4.503   6.356 -22.742  1.00 97.04           O  \\nATOM   2116  N   PHE A 269      -0.885   2.859 -19.927  1.00 97.82           N  \\nATOM   2117  CA  PHE A 269       0.069   3.446 -18.979  1.00 97.82           C  \\nATOM   2118  C   PHE A 269       1.158   2.462 -18.523  1.00 97.82           C  \\nATOM   2119  CB  PHE A 269      -0.696   4.001 -17.765  1.00 97.82           C  \\nATOM   2120  O   PHE A 269       2.103   2.876 -17.851  1.00 97.82           O  \\nATOM   2121  CG  PHE A 269      -1.818   4.966 -18.098  1.00 97.82           C  \\nATOM   2122  CD1 PHE A 269      -1.528   6.207 -18.696  1.00 97.82           C  \\nATOM   2123  CD2 PHE A 269      -3.155   4.614 -17.836  1.00 97.82           C  \\nATOM   2124  CE1 PHE A 269      -2.571   7.082 -19.043  1.00 97.82           C  \\nATOM   2125  CE2 PHE A 269      -4.197   5.501 -18.157  1.00 97.82           C  \\nATOM   2126  CZ  PHE A 269      -3.902   6.735 -18.760  1.00 97.82           C  \\nATOM   2127  N   LEU A 270       1.030   1.172 -18.859  1.00 98.20           N  \\nATOM   2128  CA  LEU A 270       2.002   0.137 -18.500  1.00 98.20           C  \\nATOM   2129  C   LEU A 270       3.204   0.156 -19.453  1.00 98.20           C  \\nATOM   2130  CB  LEU A 270       1.331  -1.250 -18.498  1.00 98.20           C  \\nATOM   2131  O   LEU A 270       3.077  -0.166 -20.639  1.00 98.20           O  \\nATOM   2132  CG  LEU A 270       0.242  -1.474 -17.436  1.00 98.20           C  \\nATOM   2133  CD1 LEU A 270      -0.336  -2.879 -17.590  1.00 98.20           C  \\nATOM   2134  CD2 LEU A 270       0.761  -1.310 -16.009  1.00 98.20           C  \\nATOM   2135  N   LEU A 271       4.379   0.470 -18.906  1.00 98.45           N  \\nATOM   2136  CA  LEU A 271       5.666   0.434 -19.603  1.00 98.45           C  \\nATOM   2137  C   LEU A 271       6.234  -0.991 -19.658  1.00 98.45           C  \\nATOM   2138  CB  LEU A 271       6.662   1.391 -18.917  1.00 98.45           C  \\nATOM   2139  O   LEU A 271       5.788  -1.891 -18.943  1.00 98.45           O  \\nATOM   2140  CG  LEU A 271       6.203   2.855 -18.789  1.00 98.45           C  \\nATOM   2141  CD1 LEU A 271       7.339   3.685 -18.185  1.00 98.45           C  \\nATOM   2142  CD2 LEU A 271       5.819   3.466 -20.135  1.00 98.45           C  \\nATOM   2143  N   GLU A 272       7.276  -1.198 -20.470  1.00 98.04           N  \\nATOM   2144  CA  GLU A 272       7.961  -2.498 -20.566  1.00 98.04           C  \\nATOM   2145  C   GLU A 272       8.487  -2.991 -19.207  1.00 98.04           C  \\nATOM   2146  CB  GLU A 272       9.079  -2.445 -21.627  1.00 98.04           C  \\nATOM   2147  O   GLU A 272       8.361  -4.169 -18.877  1.00 98.04           O  \\nATOM   2148  CG  GLU A 272      10.266  -1.503 -21.322  1.00 98.04           C  \\nATOM   2149  CD  GLU A 272      11.382  -1.551 -22.390  1.00 98.04           C  \\nATOM   2150  OE1 GLU A 272      12.395  -0.827 -22.232  1.00 98.04           O  \\nATOM   2151  OE2 GLU A 272      11.247  -2.332 -23.359  1.00 98.04           O  \\nATOM   2152  N   TYR A 273       8.988  -2.076 -18.371  1.00 98.48           N  \\nATOM   2153  CA  TYR A 273       9.506  -2.386 -17.037  1.00 98.48           C  \\nATOM   2154  C   TYR A 273       8.415  -2.924 -16.105  1.00 98.48           C  \\nATOM   2155  CB  TYR A 273      10.134  -1.123 -16.426  1.00 98.48           C  \\nATOM   2156  O   TYR A 273       8.669  -3.834 -15.318  1.00 98.48           O  \\nATOM   2157  CG  TYR A 273      10.944  -0.288 -17.399  1.00 98.48           C  \\nATOM   2158  CD1 TYR A 273      12.227  -0.703 -17.796  1.00 98.48           C  \\nATOM   2159  CD2 TYR A 273      10.380   0.875 -17.958  1.00 98.48           C  \\nATOM   2160  CE1 TYR A 273      12.960   0.064 -18.720  1.00 98.48           C  \\nATOM   2161  CE2 TYR A 273      11.100   1.629 -18.902  1.00 98.48           C  \\nATOM   2162  OH  TYR A 273      13.087   1.988 -20.168  1.00 98.48           O  \\nATOM   2163  CZ  TYR A 273      12.397   1.231 -19.279  1.00 98.48           C  \\nATOM   2164  N   ASP A 274       7.197  -2.390 -16.217  1.00 98.54           N  \\nATOM   2165  CA  ASP A 274       6.060  -2.796 -15.387  1.00 98.54           C  \\nATOM   2166  C   ASP A 274       5.639  -4.225 -15.722  1.00 98.54           C  \\nATOM   2167  CB  ASP A 274       4.884  -1.830 -15.592  1.00 98.54           C  \\nATOM   2168  O   ASP A 274       5.402  -5.035 -14.826  1.00 98.54           O  \\nATOM   2169  CG  ASP A 274       5.280  -0.378 -15.344  1.00 98.54           C  \\nATOM   2170  OD1 ASP A 274       6.015  -0.100 -14.375  1.00 98.54           O  \\nATOM   2171  OD2 ASP A 274       4.887   0.508 -16.131  1.00 98.54           O  \\nATOM   2172  N   ARG A 275       5.633  -4.555 -17.019  1.00 98.30           N  \\nATOM   2173  CA  ARG A 275       5.326  -5.899 -17.519  1.00 98.30           C  \\nATOM   2174  C   ARG A 275       6.375  -6.911 -17.065  1.00 98.30           C  \\nATOM   2175  CB  ARG A 275       5.174  -5.872 -19.048  1.00 98.30           C  \\nATOM   2176  O   ARG A 275       6.015  -7.959 -16.547  1.00 98.30           O  \\nATOM   2177  CG  ARG A 275       4.015  -4.956 -19.475  1.00 98.30           C  \\nATOM   2178  CD  ARG A 275       3.858  -4.901 -20.998  1.00 98.30           C  \\nATOM   2179  NE  ARG A 275       2.940  -3.814 -21.398  1.00 98.30           N  \\nATOM   2180  NH1 ARG A 275       0.916  -4.865 -21.028  1.00 98.30           N  \\nATOM   2181  NH2 ARG A 275       0.957  -2.754 -21.732  1.00 98.30           N  \\nATOM   2182  CZ  ARG A 275       1.616  -3.824 -21.389  1.00 98.30           C  \\nATOM   2183  N   LEU A 276       7.663  -6.567 -17.131  1.00 98.10           N  \\nATOM   2184  CA  LEU A 276       8.739  -7.432 -16.626  1.00 98.10           C  \\nATOM   2185  C   LEU A 276       8.645  -7.674 -15.109  1.00 98.10           C  \\nATOM   2186  CB  LEU A 276      10.094  -6.795 -16.972  1.00 98.10           C  \\nATOM   2187  O   LEU A 276       8.878  -8.792 -14.634  1.00 98.10           O  \\nATOM   2188  CG  LEU A 276      10.466  -6.829 -18.464  1.00 98.10           C  \\nATOM   2189  CD1 LEU A 276      11.753  -6.026 -18.669  1.00 98.10           C  \\nATOM   2190  CD2 LEU A 276      10.705  -8.254 -18.967  1.00 98.10           C  \\nATOM   2191  N   VAL A 277       8.300  -6.643 -14.329  1.00 98.15           N  \\nATOM   2192  CA  VAL A 277       8.047  -6.792 -12.886  1.00 98.15           C  \\nATOM   2193  C   VAL A 277       6.864  -7.719 -12.634  1.00 98.15           C  \\nATOM   2194  CB  VAL A 277       7.816  -5.425 -12.211  1.00 98.15           C  \\nATOM   2195  O   VAL A 277       6.956  -8.594 -11.769  1.00 98.15           O  \\nATOM   2196  CG1 VAL A 277       7.245  -5.540 -10.791  1.00 98.15           C  \\nATOM   2197  CG2 VAL A 277       9.152  -4.703 -12.076  1.00 98.15           C  \\nATOM   2198  N   ASP A 278       5.776  -7.544 -13.382  1.00 97.23           N  \\nATOM   2199  CA  ASP A 278       4.562  -8.341 -13.261  1.00 97.23           C  \\nATOM   2200  C   ASP A 278       4.784  -9.817 -13.621  1.00 97.23           C  \\nATOM   2201  CB  ASP A 278       3.455  -7.721 -14.122  1.00 97.23           C  \\nATOM   2202  O   ASP A 278       4.536 -10.689 -12.785  1.00 97.23           O  \\nATOM   2203  CG  ASP A 278       2.202  -8.581 -14.029  1.00 97.23           C  \\nATOM   2204  OD1 ASP A 278       1.765  -8.816 -12.883  1.00 97.23           O  \\nATOM   2205  OD2 ASP A 278       1.729  -9.105 -15.051  1.00 97.23           O  \\nATOM   2206  N   GLU A 279       5.335 -10.093 -14.804  1.00 97.16           N  \\nATOM   2207  CA  GLU A 279       5.606 -11.440 -15.327  1.00 97.16           C  \\nATOM   2208  C   GLU A 279       6.470 -12.269 -14.378  1.00 97.16           C  \\nATOM   2209  CB  GLU A 279       6.371 -11.318 -16.652  1.00 97.16           C  \\nATOM   2210  O   GLU A 279       6.290 -13.477 -14.222  1.00 97.16           O  \\nATOM   2211  CG  GLU A 279       5.481 -10.901 -17.831  1.00 97.16           C  \\nATOM   2212  CD  GLU A 279       6.294 -10.577 -19.096  1.00 97.16           C  \\nATOM   2213  OE1 GLU A 279       5.681 -10.053 -20.054  1.00 97.16           O  \\nATOM   2214  OE2 GLU A 279       7.513 -10.876 -19.124  1.00 97.16           O  \\nATOM   2215  N   SER A 280       7.419 -11.610 -13.720  1.00 93.40           N  \\nATOM   2216  CA  SER A 280       8.335 -12.260 -12.796  1.00 93.40           C  \\nATOM   2217  C   SER A 280       7.784 -12.325 -11.362  1.00 93.40           C  \\nATOM   2218  CB  SER A 280       9.701 -11.581 -12.934  1.00 93.40           C  \\nATOM   2219  O   SER A 280       8.391 -12.952 -10.488  1.00 93.40           O  \\nATOM   2220  OG  SER A 280       9.684 -10.234 -12.495  1.00 93.40           O  \\nATOM   2221  N   SER A 281       6.676 -11.647 -11.054  1.00 91.88           N  \\nATOM   2222  CA  SER A 281       6.115 -11.562  -9.700  1.00 91.88           C  \\nATOM   2223  C   SER A 281       5.527 -12.890  -9.200  1.00 91.88           C  \\nATOM   2224  CB  SER A 281       5.074 -10.441  -9.620  1.00 91.88           C  \\nATOM   2225  O   SER A 281       5.396 -13.873  -9.924  1.00 91.88           O  \\nATOM   2226  OG  SER A 281       3.869 -10.853 -10.217  1.00 91.88           O  \\nATOM   2227  N   ALA A 282       5.154 -12.926  -7.919  1.00 85.51           N  \\nATOM   2228  CA  ALA A 282       4.499 -14.086  -7.315  1.00 85.51           C  \\nATOM   2229  C   ALA A 282       3.087 -14.349  -7.875  1.00 85.51           C  \\nATOM   2230  CB  ALA A 282       4.453 -13.843  -5.802  1.00 85.51           C  \\nATOM   2231  O   ALA A 282       2.582 -15.464  -7.715  1.00 85.51           O  \\nATOM   2232  N   ASN A 283       2.484 -13.332  -8.489  1.00 88.03           N  \\nATOM   2233  CA  ASN A 283       1.105 -13.255  -8.949  1.00 88.03           C  \\nATOM   2234  C   ASN A 283       1.030 -12.463 -10.277  1.00 88.03           C  \\nATOM   2235  CB  ASN A 283       0.261 -12.631  -7.811  1.00 88.03           C  \\nATOM   2236  O   ASN A 283       0.561 -11.323 -10.268  1.00 88.03           O  \\nATOM   2237  CG  ASN A 283       0.723 -11.254  -7.330  1.00 88.03           C  \\nATOM   2238  ND2 ASN A 283      -0.206 -10.380  -7.029  1.00 88.03           N  \\nATOM   2239  OD1 ASN A 283       1.905 -10.956  -7.174  1.00 88.03           O  \\nATOM   2240  N   PRO A 284       1.546 -13.006 -11.398  1.00 94.19           N  \\nATOM   2241  CA  PRO A 284       1.499 -12.335 -12.701  1.00 94.19           C  \\nATOM   2242  C   PRO A 284       0.066 -12.041 -13.155  1.00 94.19           C  \\nATOM   2243  CB  PRO A 284       2.210 -13.269 -13.685  1.00 94.19           C  \\nATOM   2244  O   PRO A 284      -0.837 -12.841 -12.900  1.00 94.19           O  \\nATOM   2245  CG  PRO A 284       3.109 -14.115 -12.787  1.00 94.19           C  \\nATOM   2246  CD  PRO A 284       2.259 -14.270 -11.530  1.00 94.19           C  \\nATOM   2247  N   GLY A 285      -0.136 -10.906 -13.825  1.00 95.18           N  \\nATOM   2248  CA  GLY A 285      -1.443 -10.429 -14.280  1.00 95.18           C  \\nATOM   2249  C   GLY A 285      -2.371  -9.947 -13.163  1.00 95.18           C  \\nATOM   2250  O   GLY A 285      -3.550  -9.736 -13.418  1.00 95.18           O  \\nATOM   2251  N   GLN A 286      -1.867  -9.813 -11.932  1.00 94.36           N  \\nATOM   2252  CA  GLN A 286      -2.654  -9.382 -10.775  1.00 94.36           C  \\nATOM   2253  C   GLN A 286      -1.982  -8.241 -10.022  1.00 94.36           C  \\nATOM   2254  CB  GLN A 286      -2.886 -10.540  -9.797  1.00 94.36           C  \\nATOM   2255  O   GLN A 286      -0.753  -8.176  -9.961  1.00 94.36           O  \\nATOM   2256  CG  GLN A 286      -3.666 -11.711 -10.399  1.00 94.36           C  \\nATOM   2257  CD  GLN A 286      -3.872 -12.832  -9.386  1.00 94.36           C  \\nATOM   2258  NE2 GLN A 286      -4.129 -14.037  -9.841  1.00 94.36           N  \\nATOM   2259  OE1 GLN A 286      -3.775 -12.669  -8.178  1.00 94.36           O  \\nATOM   2260  N   GLN A 287      -2.763  -7.426  -9.317  1.00 94.94           N  \\nATOM   2261  CA  GLN A 287      -2.246  -6.348  -8.465  1.00 94.94           C  \\nATOM   2262  C   GLN A 287      -1.394  -5.330  -9.248  1.00 94.94           C  \\nATOM   2263  CB  GLN A 287      -1.528  -6.916  -7.219  1.00 94.94           C  \\nATOM   2264  O   GLN A 287      -0.367  -4.849  -8.753  1.00 94.94           O  \\nATOM   2265  CG  GLN A 287      -2.417  -7.828  -6.361  1.00 94.94           C  \\nATOM   2266  CD  GLN A 287      -3.572  -7.083  -5.702  1.00 94.94           C  \\nATOM   2267  NE2 GLN A 287      -4.671  -7.746  -5.423  1.00 94.94           N  \\nATOM   2268  OE1 GLN A 287      -3.498  -5.907  -5.395  1.00 94.94           O  \\nATOM   2269  N   LEU A 288      -1.768  -5.044 -10.501  1.00 97.51           N  \\nATOM   2270  CA  LEU A 288      -0.963  -4.210 -11.396  1.00 97.51           C  \\nATOM   2271  C   LEU A 288      -0.801  -2.780 -10.869  1.00 97.51           C  \\nATOM   2272  CB  LEU A 288      -1.572  -4.229 -12.807  1.00 97.51           C  \\nATOM   2273  O   LEU A 288       0.307  -2.244 -10.882  1.00 97.51           O  \\nATOM   2274  CG  LEU A 288      -1.497  -5.599 -13.511  1.00 97.51           C  \\nATOM   2275  CD1 LEU A 288      -2.082  -5.485 -14.914  1.00 97.51           C  \\nATOM   2276  CD2 LEU A 288      -0.063  -6.107 -13.663  1.00 97.51           C  \\nATOM   2277  N   TYR A 289      -1.856  -2.175 -10.326  1.00 98.38           N  \\nATOM   2278  CA  TYR A 289      -1.767  -0.839  -9.740  1.00 98.38           C  \\nATOM   2279  C   TYR A 289      -0.888  -0.800  -8.485  1.00 98.38           C  \\nATOM   2280  CB  TYR A 289      -3.175  -0.343  -9.444  1.00 98.38           C  \\nATOM   2281  O   TYR A 289      -0.071   0.112  -8.328  1.00 98.38           O  \\nATOM   2282  CG  TYR A 289      -3.264   1.107  -9.069  1.00 98.38           C  \\nATOM   2283  CD1 TYR A 289      -3.743   1.468  -7.800  1.00 98.38           C  \\nATOM   2284  CD2 TYR A 289      -2.959   2.084 -10.035  1.00 98.38           C  \\nATOM   2285  CE1 TYR A 289      -3.944   2.820  -7.496  1.00 98.38           C  \\nATOM   2286  CE2 TYR A 289      -3.178   3.439  -9.747  1.00 98.38           C  \\nATOM   2287  OH  TYR A 289      -3.919   5.077  -8.179  1.00 98.38           O  \\nATOM   2288  CZ  TYR A 289      -3.677   3.791  -8.478  1.00 98.38           C  \\nATOM   2289  N   GLU A 290      -0.971  -1.824  -7.626  1.00 97.42           N  \\nATOM   2290  CA  GLU A 290      -0.045  -1.967  -6.497  1.00 97.42           C  \\nATOM   2291  C   GLU A 290       1.408  -2.078  -6.986  1.00 97.42           C  \\nATOM   2292  CB  GLU A 290      -0.430  -3.165  -5.603  1.00 97.42           C  \\nATOM   2293  O   GLU A 290       2.296  -1.465  -6.394  1.00 97.42           O  \\nATOM   2294  CG  GLU A 290       0.555  -3.313  -4.433  1.00 97.42           C  \\nATOM   2295  CD  GLU A 290       0.189  -4.395  -3.404  1.00 97.42           C  \\nATOM   2296  OE1 GLU A 290       0.736  -5.522  -3.515  1.00 97.42           O  \\nATOM   2297  OE2 GLU A 290      -0.456  -4.029  -2.394  1.00 97.42           O  \\nATOM   2298  N   LYS A 291       1.670  -2.795  -8.085  1.00 97.14           N  \\nATOM   2299  CA  LYS A 291       3.019  -2.950  -8.659  1.00 97.14           C  \\nATOM   2300  C   LYS A 291       3.625  -1.650  -9.183  1.00 97.14           C  \\nATOM   2301  CB  LYS A 291       3.004  -4.040  -9.738  1.00 97.14           C  \\nATOM   2302  O   LYS A 291       4.843  -1.489  -9.128  1.00 97.14           O  \\nATOM   2303  CG  LYS A 291       2.933  -5.432  -9.101  1.00 97.14           C  \\nATOM   2304  CD  LYS A 291       2.498  -6.484 -10.118  1.00 97.14           C  \\nATOM   2305  CE  LYS A 291       2.535  -7.857  -9.451  1.00 97.14           C  \\nATOM   2306  NZ  LYS A 291       1.838  -8.853 -10.278  1.00 97.14           N  \\nATOM   2307  N   LEU A 292       2.798  -0.702  -9.618  1.00 98.11           N  \\nATOM   2308  CA  LEU A 292       3.253   0.615 -10.076  1.00 98.11           C  \\nATOM   2309  C   LEU A 292       3.658   1.559  -8.933  1.00 98.11           C  \\nATOM   2310  CB  LEU A 292       2.140   1.260 -10.918  1.00 98.11           C  \\nATOM   2311  O   LEU A 292       4.398   2.515  -9.172  1.00 98.11           O  \\nATOM   2312  CG  LEU A 292       1.820   0.529 -12.233  1.00 98.11           C  \\nATOM   2313  CD1 LEU A 292       0.645   1.226 -12.910  1.00 98.11           C  \\nATOM   2314  CD2 LEU A 292       3.003   0.535 -13.194  1.00 98.11           C  \\nATOM   2315  N   ILE A 293       3.155   1.328  -7.715  1.00 98.28           N  \\nATOM   2316  CA  ILE A 293       3.244   2.282  -6.595  1.00 98.28           C  \\nATOM   2317  C   ILE A 293       4.026   1.709  -5.410  1.00 98.28           C  \\nATOM   2318  CB  ILE A 293       1.820   2.713  -6.161  1.00 98.28           C  \\nATOM   2319  O   ILE A 293       4.834   2.402  -4.788  1.00 98.28           O  \\nATOM   2320  CG1 ILE A 293       1.051   3.387  -7.323  1.00 98.28           C  \\nATOM   2321  CG2 ILE A 293       1.889   3.676  -4.955  1.00 98.28           C  \\nATOM   2322  CD1 ILE A 293      -0.457   3.490  -7.073  1.00 98.28           C  \\nATOM   2323  N   GLY A 294       3.755   0.450  -5.073  1.00 95.52           N  \\nATOM   2324  CA  GLY A 294       4.204  -0.208  -3.858  1.00 95.52           C  \\nATOM   2325  C   GLY A 294       5.722  -0.292  -3.757  1.00 95.52           C  \\nATOM   2326  O   GLY A 294       6.438  -0.655  -4.695  1.00 95.52           O  \\nATOM   2327  N   GLY A 295       6.225  -0.031  -2.556  1.00 95.57           N  \\nATOM   2328  CA  GLY A 295       7.639  -0.114  -2.221  1.00 95.57           C  \\nATOM   2329  C   GLY A 295       8.224  -1.517  -2.371  1.00 95.57           C  \\nATOM   2330  O   GLY A 295       9.442  -1.649  -2.400  1.00 95.57           O  \\nATOM   2331  N   LYS A 296       7.410  -2.568  -2.519  1.00 93.42           N  \\nATOM   2332  CA  LYS A 296       7.898  -3.898  -2.906  1.00 93.42           C  \\nATOM   2333  C   LYS A 296       8.521  -3.922  -4.308  1.00 93.42           C  \\nATOM   2334  CB  LYS A 296       6.737  -4.896  -2.795  1.00 93.42           C  \\nATOM   2335  O   LYS A 296       9.429  -4.712  -4.548  1.00 93.42           O  \\nATOM   2336  CG  LYS A 296       7.193  -6.312  -3.152  1.00 93.42           C  \\nATOM   2337  CD  LYS A 296       6.186  -7.380  -2.732  1.00 93.42           C  \\nATOM   2338  CE  LYS A 296       6.840  -8.716  -3.083  1.00 93.42           C  \\nATOM   2339  NZ  LYS A 296       6.147  -9.857  -2.458  1.00 93.42           N  \\nATOM   2340  N   TYR A 297       8.043  -3.073  -5.215  1.00 96.72           N  \\nATOM   2341  CA  TYR A 297       8.346  -3.151  -6.647  1.00 96.72           C  \\nATOM   2342  C   TYR A 297       9.165  -1.961  -7.158  1.00 96.72           C  \\nATOM   2343  CB  TYR A 297       7.017  -3.272  -7.396  1.00 96.72           C  \\nATOM   2344  O   TYR A 297       9.899  -2.095  -8.133  1.00 96.72           O  \\nATOM   2345  CG  TYR A 297       6.135  -4.409  -6.905  1.00 96.72           C  \\nATOM   2346  CD1 TYR A 297       6.422  -5.743  -7.255  1.00 96.72           C  \\nATOM   2347  CD2 TYR A 297       5.030  -4.125  -6.078  1.00 96.72           C  \\nATOM   2348  CE1 TYR A 297       5.582  -6.786  -6.813  1.00 96.72           C  \\nATOM   2349  CE2 TYR A 297       4.173  -5.158  -5.661  1.00 96.72           C  \\nATOM   2350  OH  TYR A 297       3.609  -7.479  -5.622  1.00 96.72           O  \\nATOM   2351  CZ  TYR A 297       4.443  -6.489  -6.032  1.00 96.72           C  \\nATOM   2352  N   MET A 298       9.103  -0.817  -6.469  1.00 98.22           N  \\nATOM   2353  CA  MET A 298       9.765   0.429  -6.876  1.00 98.22           C  \\nATOM   2354  C   MET A 298      11.270   0.276  -7.151  1.00 98.22           C  \\nATOM   2355  CB  MET A 298       9.504   1.475  -5.786  1.00 98.22           C  \\nATOM   2356  O   MET A 298      11.760   0.751  -8.174  1.00 98.22           O  \\nATOM   2357  CG  MET A 298       9.989   2.872  -6.184  1.00 98.22           C  \\nATOM   2358  SD  MET A 298       9.701   4.144  -4.925  1.00 98.22           S  \\nATOM   2359  CE  MET A 298       7.887   4.211  -4.938  1.00 98.22           C  \\nATOM   2360  N   GLY A 299      12.009  -0.406  -6.272  1.00 98.36           N  \\nATOM   2361  CA  GLY A 299      13.436  -0.659  -6.481  1.00 98.36           C  \\nATOM   2362  C   GLY A 299      13.728  -1.521  -7.716  1.00 98.36           C  \\nATOM   2363  O   GLY A 299      14.647  -1.219  -8.477  1.00 98.36           O  \\nATOM   2364  N   GLU A 300      12.901  -2.537  -7.974  1.00 98.34           N  \\nATOM   2365  CA  GLU A 300      13.043  -3.397  -9.153  1.00 98.34           C  \\nATOM   2366  C   GLU A 300      12.731  -2.641 -10.450  1.00 98.34           C  \\nATOM   2367  CB  GLU A 300      12.157  -4.643  -8.992  1.00 98.34           C  \\nATOM   2368  O   GLU A 300      13.454  -2.800 -11.432  1.00 98.34           O  \\nATOM   2369  CG  GLU A 300      12.235  -5.614 -10.179  1.00 98.34           C  \\nATOM   2370  CD  GLU A 300      13.619  -6.212 -10.433  1.00 98.34           C  \\nATOM   2371  OE1 GLU A 300      13.808  -6.854 -11.486  1.00 98.34           O  \\nATOM   2372  OE2 GLU A 300      14.535  -6.108  -9.586  1.00 98.34           O  \\nATOM   2373  N   LEU A 301      11.724  -1.761 -10.443  1.00 98.71           N  \\nATOM   2374  CA  LEU A 301      11.445  -0.869 -11.571  1.00 98.71           C  \\nATOM   2375  C   LEU A 301      12.659   0.005 -11.895  1.00 98.71           C  \\nATOM   2376  CB  LEU A 301      10.222   0.009 -11.256  1.00 98.71           C  \\nATOM   2377  O   LEU A 301      13.086   0.059 -13.047  1.00 98.71           O  \\nATOM   2378  CG  LEU A 301       8.881  -0.739 -11.284  1.00 98.71           C  \\nATOM   2379  CD1 LEU A 301       7.787   0.165 -10.718  1.00 98.71           C  \\nATOM   2380  CD2 LEU A 301       8.504  -1.137 -12.710  1.00 98.71           C  \\nATOM   2381  N   VAL A 302      13.272   0.626 -10.880  1.00 98.81           N  \\nATOM   2382  CA  VAL A 302      14.509   1.396 -11.075  1.00 98.81           C  \\nATOM   2383  C   VAL A 302      15.614   0.504 -11.632  1.00 98.81           C  \\nATOM   2384  CB  VAL A 302      14.957   2.105  -9.782  1.00 98.81           C  \\nATOM   2385  O   VAL A 302      16.250   0.881 -12.611  1.00 98.81           O  \\nATOM   2386  CG1 VAL A 302      16.337   2.761  -9.930  1.00 98.81           C  \\nATOM   2387  CG2 VAL A 302      13.962   3.215  -9.421  1.00 98.81           C  \\nATOM   2388  N   ARG A 303      15.823  -0.697 -11.078  1.00 98.70           N  \\nATOM   2389  CA  ARG A 303      16.848  -1.638 -11.558  1.00 98.70           C  \\nATOM   2390  C   ARG A 303      16.712  -1.927 -13.052  1.00 98.70           C  \\nATOM   2391  CB  ARG A 303      16.740  -2.956 -10.784  1.00 98.70           C  \\nATOM   2392  O   ARG A 303      17.713  -1.900 -13.764  1.00 98.70           O  \\nATOM   2393  CG  ARG A 303      18.019  -3.794 -10.913  1.00 98.70           C  \\nATOM   2394  CD  ARG A 303      17.806  -5.187 -10.317  1.00 98.70           C  \\nATOM   2395  NE  ARG A 303      16.832  -5.958 -11.106  1.00 98.70           N  \\nATOM   2396  NH1 ARG A 303      18.259  -6.743 -12.698  1.00 98.70           N  \\nATOM   2397  NH2 ARG A 303      16.087  -7.198 -12.854  1.00 98.70           N  \\nATOM   2398  CZ  ARG A 303      17.059  -6.619 -12.219  1.00 98.70           C  \\nATOM   2399  N   LEU A 304      15.493  -2.193 -13.520  1.00 98.78           N  \\nATOM   2400  CA  LEU A 304      15.219  -2.487 -14.926  1.00 98.78           C  \\nATOM   2401  C   LEU A 304      15.481  -1.271 -15.825  1.00 98.78           C  \\nATOM   2402  CB  LEU A 304      13.774  -2.985 -15.068  1.00 98.78           C  \\nATOM   2403  O   LEU A 304      16.093  -1.425 -16.879  1.00 98.78           O  \\nATOM   2404  CG  LEU A 304      13.496  -4.354 -14.425  1.00 98.78           C  \\nATOM   2405  CD1 LEU A 304      11.992  -4.592 -14.431  1.00 98.78           C  \\nATOM   2406  CD2 LEU A 304      14.170  -5.495 -15.191  1.00 98.78           C  \\nATOM   2407  N   VAL A 305      15.125  -0.061 -15.378  1.00 98.70           N  \\nATOM   2408  CA  VAL A 305      15.486   1.186 -16.079  1.00 98.70           C  \\nATOM   2409  C   VAL A 305      17.005   1.345 -16.160  1.00 98.70           C  \\nATOM   2410  CB  VAL A 305      14.853   2.414 -15.397  1.00 98.70           C  \\nATOM   2411  O   VAL A 305      17.538   1.677 -17.217  1.00 98.70           O  \\nATOM   2412  CG1 VAL A 305      15.287   3.738 -16.041  1.00 98.70           C  \\nATOM   2413  CG2 VAL A 305      13.329   2.360 -15.487  1.00 98.70           C  \\nATOM   2414  N   LEU A 306      17.735   1.066 -15.074  1.00 98.72           N  \\nATOM   2415  CA  LEU A 306      19.199   1.127 -15.086  1.00 98.72           C  \\nATOM   2416  C   LEU A 306      19.797   0.117 -16.071  1.00 98.72           C  \\nATOM   2417  CB  LEU A 306      19.786   0.923 -13.677  1.00 98.72           C  \\nATOM   2418  O   LEU A 306      20.716   0.477 -16.802  1.00 98.72           O  \\nATOM   2419  CG  LEU A 306      19.394   1.964 -12.612  1.00 98.72           C  \\nATOM   2420  CD1 LEU A 306      20.190   1.705 -11.332  1.00 98.72           C  \\nATOM   2421  CD2 LEU A 306      19.605   3.410 -13.055  1.00 98.72           C  \\nATOM   2422  N   LEU A 307      19.273  -1.112 -16.134  1.00 98.55           N  \\nATOM   2423  CA  LEU A 307      19.714  -2.104 -17.119  1.00 98.55           C  \\nATOM   2424  C   LEU A 307      19.454  -1.641 -18.554  1.00 98.55           C  \\nATOM   2425  CB  LEU A 307      19.044  -3.464 -16.871  1.00 98.55           C  \\nATOM   2426  O   LEU A 307      20.363  -1.707 -19.376  1.00 98.55           O  \\nATOM   2427  CG  LEU A 307      19.543  -4.239 -15.641  1.00 98.55           C  \\nATOM   2428  CD1 LEU A 307      18.869  -5.612 -15.646  1.00 98.55           C  \\nATOM   2429  CD2 LEU A 307      21.059  -4.461 -15.631  1.00 98.55           C  \\nATOM   2430  N   ARG A 308      18.277  -1.074 -18.838  1.00 98.34           N  \\nATOM   2431  CA  ARG A 308      17.972  -0.504 -20.157  1.00 98.34           C  \\nATOM   2432  C   ARG A 308      18.960   0.594 -20.550  1.00 98.34           C  \\nATOM   2433  CB  ARG A 308      16.529   0.018 -20.136  1.00 98.34           C  \\nATOM   2434  O   ARG A 308      19.440   0.623 -21.681  1.00 98.34           O  \\nATOM   2435  CG  ARG A 308      16.047   0.578 -21.479  1.00 98.34           C  \\nATOM   2436  CD  ARG A 308      15.855  -0.542 -22.501  1.00 98.34           C  \\nATOM   2437  NE  ARG A 308      15.251  -0.015 -23.732  1.00 98.34           N  \\nATOM   2438  NH1 ARG A 308      16.741  -0.899 -25.219  1.00 98.34           N  \\nATOM   2439  NH2 ARG A 308      15.385   0.701 -25.894  1.00 98.34           N  \\nATOM   2440  CZ  ARG A 308      15.770  -0.087 -24.936  1.00 98.34           C  \\nATOM   2441  N   LEU A 309      19.299   1.483 -19.616  1.00 98.53           N  \\nATOM   2442  CA  LEU A 309      20.278   2.548 -19.845  1.00 98.53           C  \\nATOM   2443  C   LEU A 309      21.697   2.003 -20.062  1.00 98.53           C  \\nATOM   2444  CB  LEU A 309      20.249   3.527 -18.661  1.00 98.53           C  \\nATOM   2445  O   LEU A 309      22.455   2.577 -20.845  1.00 98.53           O  \\nATOM   2446  CG  LEU A 309      18.951   4.346 -18.532  1.00 98.53           C  \\nATOM   2447  CD1 LEU A 309      18.957   5.083 -17.194  1.00 98.53           C  \\nATOM   2448  CD2 LEU A 309      18.828   5.380 -19.650  1.00 98.53           C  \\nATOM   2449  N   VAL A 310      22.067   0.906 -19.399  1.00 98.14           N  \\nATOM   2450  CA  VAL A 310      23.329   0.199 -19.656  1.00 98.14           C  \\nATOM   2451  C   VAL A 310      23.323  -0.403 -21.061  1.00 98.14           C  \\nATOM   2452  CB  VAL A 310      23.591  -0.873 -18.584  1.00 98.14           C  \\nATOM   2453  O   VAL A 310      24.246  -0.136 -21.825  1.00 98.14           O  \\nATOM   2454  CG1 VAL A 310      24.771  -1.775 -18.942  1.00 98.14           C  \\nATOM   2455  CG2 VAL A 310      23.937  -0.232 -17.232  1.00 98.14           C  \\nATOM   2456  N   ASP A 311      22.278  -1.139 -21.438  1.00 97.49           N  \\nATOM   2457  CA  ASP A 311      22.187  -1.809 -22.744  1.00 97.49           C  \\nATOM   2458  C   ASP A 311      22.213  -0.811 -23.917  1.00 97.49           C  \\nATOM   2459  CB  ASP A 311      20.910  -2.667 -22.787  1.00 97.49           C  \\nATOM   2460  O   ASP A 311      22.756  -1.094 -24.984  1.00 97.49           O  \\nATOM   2461  CG  ASP A 311      20.930  -3.879 -21.842  1.00 97.49           C  \\nATOM   2462  OD1 ASP A 311      22.031  -4.302 -21.414  1.00 97.49           O  \\nATOM   2463  OD2 ASP A 311      19.826  -4.410 -21.587  1.00 97.49           O  \\nATOM   2464  N   GLU A 312      21.702   0.405 -23.705  1.00 96.99           N  \\nATOM   2465  CA  GLU A 312      21.763   1.519 -24.663  1.00 96.99           C  \\nATOM   2466  C   GLU A 312      23.104   2.292 -24.641  1.00 96.99           C  \\nATOM   2467  CB  GLU A 312      20.552   2.440 -24.424  1.00 96.99           C  \\nATOM   2468  O   GLU A 312      23.244   3.314 -25.322  1.00 96.99           O  \\nATOM   2469  CG  GLU A 312      19.209   1.790 -24.820  1.00 96.99           C  \\nATOM   2470  CD  GLU A 312      19.022   1.608 -26.337  1.00 96.99           C  \\nATOM   2471  OE1 GLU A 312      18.115   0.847 -26.747  1.00 96.99           O  \\nATOM   2472  OE2 GLU A 312      19.724   2.291 -27.120  1.00 96.99           O  \\nATOM   2473  N   ASN A 313      24.096   1.816 -23.875  1.00 96.35           N  \\nATOM   2474  CA  ASN A 313      25.411   2.430 -23.642  1.00 96.35           C  \\nATOM   2475  C   ASN A 313      25.336   3.868 -23.079  1.00 96.35           C  \\nATOM   2476  CB  ASN A 313      26.283   2.264 -24.898  1.00 96.35           C  \\nATOM   2477  O   ASN A 313      26.169   4.735 -23.363  1.00 96.35           O  \\nATOM   2478  CG  ASN A 313      27.757   2.531 -24.648  1.00 96.35           C  \\nATOM   2479  ND2 ASN A 313      28.493   2.884 -25.676  1.00 96.35           N  \\nATOM   2480  OD1 ASN A 313      28.288   2.416 -23.558  1.00 96.35           O  \\nATOM   2481  N   LEU A 314      24.309   4.138 -22.270  1.00 97.14           N  \\nATOM   2482  CA  LEU A 314      24.054   5.426 -21.618  1.00 97.14           C  \\nATOM   2483  C   LEU A 314      24.451   5.429 -20.140  1.00 97.14           C  \\nATOM   2484  CB  LEU A 314      22.571   5.801 -21.764  1.00 97.14           C  \\nATOM   2485  O   LEU A 314      24.515   6.492 -19.525  1.00 97.14           O  \\nATOM   2486  CG  LEU A 314      22.081   5.917 -23.213  1.00 97.14           C  \\nATOM   2487  CD1 LEU A 314      20.569   6.102 -23.224  1.00 97.14           C  \\nATOM   2488  CD2 LEU A 314      22.740   7.092 -23.938  1.00 97.14           C  \\nATOM   2489  N   LEU A 315      24.764   4.279 -19.556  1.00 97.24           N  \\nATOM   2490  CA  LEU A 315      25.126   4.177 -18.148  1.00 97.24           C  \\nATOM   2491  C   LEU A 315      26.269   3.179 -17.958  1.00 97.24           C  \\nATOM   2492  CB  LEU A 315      23.848   3.809 -17.377  1.00 97.24           C  \\nATOM   2493  O   LEU A 315      26.328   2.168 -18.654  1.00 97.24           O  \\nATOM   2494  CG  LEU A 315      23.966   3.931 -15.856  1.00 97.24           C  \\nATOM   2495  CD1 LEU A 315      24.131   5.377 -15.392  1.00 97.24           C  \\nATOM   2496  CD2 LEU A 315      22.707   3.368 -15.203  1.00 97.24           C  \\nATOM   2497  N   PHE A 316      27.201   3.494 -17.053  1.00 96.73           N  \\nATOM   2498  CA  PHE A 316      28.316   2.614 -16.661  1.00 96.73           C  \\nATOM   2499  C   PHE A 316      29.141   2.072 -17.842  1.00 96.73           C  \\nATOM   2500  CB  PHE A 316      27.819   1.491 -15.731  1.00 96.73           C  \\nATOM   2501  O   PHE A 316      29.593   0.933 -17.824  1.00 96.73           O  \\nATOM   2502  CG  PHE A 316      26.925   1.931 -14.588  1.00 96.73           C  \\nATOM   2503  CD1 PHE A 316      27.260   3.053 -13.805  1.00 96.73           C  \\nATOM   2504  CD2 PHE A 316      25.735   1.227 -14.325  1.00 96.73           C  \\nATOM   2505  CE1 PHE A 316      26.384   3.488 -12.796  1.00 96.73           C  \\nATOM   2506  CE2 PHE A 316      24.856   1.671 -13.323  1.00 96.73           C  \\nATOM   2507  CZ  PHE A 316      25.177   2.810 -12.567  1.00 96.73           C  \\nATOM   2508  N   HIS A 317      29.327   2.885 -18.888  1.00 93.79           N  \\nATOM   2509  CA  HIS A 317      30.048   2.502 -20.113  1.00 93.79           C  \\nATOM   2510  C   HIS A 317      29.492   1.252 -20.822  1.00 93.79           C  \\nATOM   2511  CB  HIS A 317      31.557   2.401 -19.824  1.00 93.79           C  \\nATOM   2512  O   HIS A 317      30.238   0.553 -21.503  1.00 93.79           O  \\nATOM   2513  CG  HIS A 317      32.133   3.653 -19.224  1.00 93.79           C  \\nATOM   2514  CD2 HIS A 317      32.505   3.853 -17.922  1.00 93.79           C  \\nATOM   2515  ND1 HIS A 317      32.372   4.822 -19.904  1.00 93.79           N  \\nATOM   2516  CE1 HIS A 317      32.881   5.708 -19.035  1.00 93.79           C  \\nATOM   2517  NE2 HIS A 317      32.988   5.166 -17.814  1.00 93.79           N  \\nATOM   2518  N   GLY A 318      28.196   0.972 -20.660  1.00 95.50           N  \\nATOM   2519  CA  GLY A 318      27.554  -0.188 -21.273  1.00 95.50           C  \\nATOM   2520  C   GLY A 318      27.805  -1.506 -20.540  1.00 95.50           C  \\nATOM   2521  O   GLY A 318      27.440  -2.565 -21.043  1.00 95.50           O  \\nATOM   2522  N   GLU A 319      28.394  -1.462 -19.341  1.00 95.89           N  \\nATOM   2523  CA  GLU A 319      28.722  -2.649 -18.554  1.00 95.89           C  \\nATOM   2524  C   GLU A 319      28.010  -2.636 -17.192  1.00 95.89           C  \\nATOM   2525  CB  GLU A 319      30.246  -2.777 -18.400  1.00 95.89           C  \\nATOM   2526  O   GLU A 319      28.374  -1.909 -16.268  1.00 95.89           O  \\nATOM   2527  CG  GLU A 319      30.957  -3.041 -19.741  1.00 95.89           C  \\nATOM   2528  CD  GLU A 319      32.474  -3.271 -19.600  1.00 95.89           C  \\nATOM   2529  OE1 GLU A 319      33.126  -3.494 -20.647  1.00 95.89           O  \\nATOM   2530  OE2 GLU A 319      32.993  -3.250 -18.458  1.00 95.89           O  \\nATOM   2531  N   ALA A 320      26.994  -3.489 -17.039  1.00 95.63           N  \\nATOM   2532  CA  ALA A 320      26.408  -3.780 -15.733  1.00 95.63           C  \\nATOM   2533  C   ALA A 320      27.305  -4.745 -14.940  1.00 95.63           C  \\nATOM   2534  CB  ALA A 320      24.980  -4.325 -15.887  1.00 95.63           C  \\nATOM   2535  O   ALA A 320      27.967  -5.618 -15.510  1.00 95.63           O  \\nATOM   2536  N   SER A 321      27.271  -4.629 -13.615  1.00 96.81           N  \\nATOM   2537  CA  SER A 321      27.836  -5.621 -12.700  1.00 96.81           C  \\nATOM   2538  C   SER A 321      26.909  -6.832 -12.547  1.00 96.81           C  \\nATOM   2539  CB  SER A 321      28.071  -4.974 -11.337  1.00 96.81           C  \\nATOM   2540  O   SER A 321      25.699  -6.742 -12.767  1.00 96.81           O  \\nATOM   2541  OG  SER A 321      26.828  -4.565 -10.802  1.00 96.81           O  \\nATOM   2542  N   GLU A 322      27.456  -7.960 -12.092  1.00 96.83           N  \\nATOM   2543  CA  GLU A 322      26.658  -9.156 -11.780  1.00 96.83           C  \\nATOM   2544  C   GLU A 322      25.626  -8.890 -10.672  1.00 96.83           C  \\nATOM   2545  CB  GLU A 322      27.597 -10.309 -11.380  1.00 96.83           C  \\nATOM   2546  O   GLU A 322      24.499  -9.388 -10.716  1.00 96.83           O  \\nATOM   2547  CG  GLU A 322      28.507 -10.764 -12.533  1.00 96.83           C  \\nATOM   2548  CD  GLU A 322      27.678 -11.120 -13.774  1.00 96.83           C  \\nATOM   2549  OE1 GLU A 322      27.706 -10.327 -14.747  1.00 96.83           O  \\nATOM   2550  OE2 GLU A 322      26.942 -12.124 -13.706  1.00 96.83           O  \\nATOM   2551  N   GLN A 323      25.966  -8.029  -9.709  1.00 97.05           N  \\nATOM   2552  CA  GLN A 323      25.046  -7.605  -8.657  1.00 97.05           C  \\nATOM   2553  C   GLN A 323      23.870  -6.806  -9.231  1.00 97.05           C  \\nATOM   2554  CB  GLN A 323      25.773  -6.777  -7.587  1.00 97.05           C  \\nATOM   2555  O   GLN A 323      22.733  -7.102  -8.886  1.00 97.05           O  \\nATOM   2556  CG  GLN A 323      26.843  -7.539  -6.787  1.00 97.05           C  \\nATOM   2557  CD  GLN A 323      28.213  -7.650  -7.458  1.00 97.05           C  \\nATOM   2558  NE2 GLN A 323      29.206  -8.132  -6.746  1.00 97.05           N  \\nATOM   2559  OE1 GLN A 323      28.439  -7.316  -8.611  1.00 97.05           O  \\nATOM   2560  N   LEU A 324      24.099  -5.847 -10.140  1.00 97.70           N  \\nATOM   2561  CA  LEU A 324      23.008  -5.074 -10.752  1.00 97.70           C  \\nATOM   2562  C   LEU A 324      22.108  -5.951 -11.645  1.00 97.70           C  \\nATOM   2563  CB  LEU A 324      23.600  -3.885 -11.535  1.00 97.70           C  \\nATOM   2564  O   LEU A 324      20.893  -5.740 -11.710  1.00 97.70           O  \\nATOM   2565  CG  LEU A 324      22.538  -2.964 -12.173  1.00 97.70           C  \\nATOM   2566  CD1 LEU A 324      21.685  -2.252 -11.120  1.00 97.70           C  \\nATOM   2567  CD2 LEU A 324      23.201  -1.899 -13.046  1.00 97.70           C  \\nATOM   2568  N   ARG A 325      22.685  -6.962 -12.309  1.00 97.47           N  \\nATOM   2569  CA  ARG A 325      21.923  -7.949 -13.095  1.00 97.47           C  \\nATOM   2570  C   ARG A 325      21.019  -8.827 -12.232  1.00 97.47           C  \\nATOM   2571  CB  ARG A 325      22.873  -8.830 -13.920  1.00 97.47           C  \\nATOM   2572  O   ARG A 325      20.005  -9.314 -12.731  1.00 97.47           O  \\nATOM   2573  CG  ARG A 325      23.494  -8.067 -15.094  1.00 97.47           C  \\nATOM   2574  CD  ARG A 325      24.284  -9.023 -15.994  1.00 97.47           C  \\nATOM   2575  NE  ARG A 325      24.871  -8.296 -17.133  1.00 97.47           N  \\nATOM   2576  NH1 ARG A 325      27.025  -8.113 -16.318  1.00 97.47           N  \\nATOM   2577  NH2 ARG A 325      26.423  -6.957 -18.112  1.00 97.47           N  \\nATOM   2578  CZ  ARG A 325      26.097  -7.808 -17.179  1.00 97.47           C  \\nATOM   2579  N   THR A 326      21.343  -8.998 -10.953  1.00 97.57           N  \\nATOM   2580  CA  THR A 326      20.552  -9.812 -10.028  1.00 97.57           C  \\nATOM   2581  C   THR A 326      19.220  -9.128  -9.710  1.00 97.57           C  \\nATOM   2582  CB  THR A 326      21.353 -10.127  -8.757  1.00 97.57           C  \\nATOM   2583  O   THR A 326      19.175  -7.986  -9.251  1.00 97.57           O  \\nATOM   2584  CG2 THR A 326      20.591 -11.056  -7.812  1.00 97.57           C  \\nATOM   2585  OG1 THR A 326      22.546 -10.803  -9.099  1.00 97.57           O  \\nATOM   2586  N   ARG A 327      18.110  -9.830  -9.957  1.00 96.12           N  \\nATOM   2587  CA  ARG A 327      16.754  -9.351  -9.657  1.00 96.12           C  \\nATOM   2588  C   ARG A 327      16.603  -8.997  -8.176  1.00 96.12           C  \\nATOM   2589  CB  ARG A 327      15.743 -10.416 -10.093  1.00 96.12           C  \\nATOM   2590  O   ARG A 327      17.056  -9.747  -7.318  1.00 96.12           O  \\nATOM   2591  CG  ARG A 327      14.312  -9.953  -9.823  1.00 96.12           C  \\nATOM   2592  CD  ARG A 327      13.318 -10.949 -10.393  1.00 96.12           C  \\nATOM   2593  NE  ARG A 327      11.955 -10.493 -10.112  1.00 96.12           N  \\nATOM   2594  NH1 ARG A 327      10.994 -12.557  -9.903  1.00 96.12           N  \\nATOM   2595  NH2 ARG A 327       9.753 -10.723  -9.661  1.00 96.12           N  \\nATOM   2596  CZ  ARG A 327      10.914 -11.256  -9.884  1.00 96.12           C  \\nATOM   2597  N   GLY A 328      15.954  -7.871  -7.885  1.00 94.61           N  \\nATOM   2598  CA  GLY A 328      15.738  -7.391  -6.520  1.00 94.61           C  \\nATOM   2599  C   GLY A 328      16.977  -6.800  -5.839  1.00 94.61           C  \\nATOM   2600  O   GLY A 328      16.873  -6.358  -4.700  1.00 94.61           O  \\nATOM   2601  N   ALA A 329      18.137  -6.745  -6.509  1.00 96.69           N  \\nATOM   2602  CA  ALA A 329      19.364  -6.212  -5.910  1.00 96.69           C  \\nATOM   2603  C   ALA A 329      19.336  -4.690  -5.693  1.00 96.69           C  \\nATOM   2604  CB  ALA A 329      20.546  -6.606  -6.795  1.00 96.69           C  \\nATOM   2605  O   ALA A 329      20.056  -4.180  -4.836  1.00 96.69           O  \\nATOM   2606  N   PHE A 330      18.517  -3.954  -6.453  1.00 98.18           N  \\nATOM   2607  CA  PHE A 330      18.291  -2.531  -6.214  1.00 98.18           C  \\nATOM   2608  C   PHE A 330      17.053  -2.358  -5.333  1.00 98.18           C  \\nATOM   2609  CB  PHE A 330      18.209  -1.752  -7.530  1.00 98.18           C  \\nATOM   2610  O   PHE A 330      15.921  -2.365  -5.803  1.00 98.18           O  \\nATOM   2611  CG  PHE A 330      18.499  -0.275  -7.364  1.00 98.18           C  \\nATOM   2612  CD1 PHE A 330      17.498   0.602  -6.905  1.00 98.18           C  \\nATOM   2613  CD2 PHE A 330      19.783   0.223  -7.653  1.00 98.18           C  \\nATOM   2614  CE1 PHE A 330      17.788   1.967  -6.733  1.00 98.18           C  \\nATOM   2615  CE2 PHE A 330      20.071   1.588  -7.482  1.00 98.18           C  \\nATOM   2616  CZ  PHE A 330      19.070   2.462  -7.024  1.00 98.18           C  \\nATOM   2617  N   GLU A 331      17.263  -2.250  -4.027  1.00 96.58           N  \\nATOM   2618  CA  GLU A 331      16.176  -2.151  -3.056  1.00 96.58           C  \\nATOM   2619  C   GLU A 331      15.514  -0.764  -3.060  1.00 96.58           C  \\nATOM   2620  CB  GLU A 331      16.723  -2.457  -1.661  1.00 96.58           C  \\nATOM   2621  O   GLU A 331      16.160   0.258  -3.286  1.00 96.58           O  \\nATOM   2622  CG  GLU A 331      17.264  -3.885  -1.498  1.00 96.58           C  \\nATOM   2623  CD  GLU A 331      17.944  -4.008  -0.133  1.00 96.58           C  \\nATOM   2624  OE1 GLU A 331      19.180  -4.192  -0.077  1.00 96.58           O  \\nATOM   2625  OE2 GLU A 331      17.285  -3.723   0.892  1.00 96.58           O  \\nATOM   2626  N   THR A 332      14.236  -0.688  -2.688  1.00 97.31           N  \\nATOM   2627  CA  THR A 332      13.499   0.588  -2.594  1.00 97.31           C  \\nATOM   2628  C   THR A 332      14.137   1.589  -1.627  1.00 97.31           C  \\nATOM   2629  CB  THR A 332      12.048   0.305  -2.207  1.00 97.31           C  \\nATOM   2630  O   THR A 332      14.095   2.793  -1.866  1.00 97.31           O  \\nATOM   2631  CG2 THR A 332      11.182   1.554  -2.054  1.00 97.31           C  \\nATOM   2632  OG1 THR A 332      11.527  -0.469  -3.257  1.00 97.31           O  \\nATOM   2633  N   ARG A 333      14.827   1.123  -0.575  1.00 96.92           N  \\nATOM   2634  CA  ARG A 333      15.606   2.013   0.304  1.00 96.92           C  \\nATOM   2635  C   ARG A 333      16.711   2.765  -0.446  1.00 96.92           C  \\nATOM   2636  CB  ARG A 333      16.165   1.240   1.509  1.00 96.92           C  \\nATOM   2637  O   ARG A 333      17.026   3.888  -0.064  1.00 96.92           O  \\nATOM   2638  CG  ARG A 333      17.238   0.212   1.120  1.00 96.92           C  \\nATOM   2639  CD  ARG A 333      17.720  -0.582   2.334  1.00 96.92           C  \\nATOM   2640  NE  ARG A 333      18.690  -1.605   1.925  1.00 96.92           N  \\nATOM   2641  NH1 ARG A 333      20.629  -0.408   2.133  1.00 96.92           N  \\nATOM   2642  NH2 ARG A 333      20.692  -2.507   1.376  1.00 96.92           N  \\nATOM   2643  CZ  ARG A 333      19.997  -1.504   1.814  1.00 96.92           C  \\nATOM   2644  N   PHE A 334      17.283   2.182  -1.503  1.00 98.17           N  \\nATOM   2645  CA  PHE A 334      18.263   2.868  -2.342  1.00 98.17           C  \\nATOM   2646  C   PHE A 334      17.620   3.986  -3.157  1.00 98.17           C  \\nATOM   2647  CB  PHE A 334      18.988   1.889  -3.272  1.00 98.17           C  \\nATOM   2648  O   PHE A 334      18.245   5.029  -3.302  1.00 98.17           O  \\nATOM   2649  CG  PHE A 334      19.825   0.815  -2.603  1.00 98.17           C  \\nATOM   2650  CD1 PHE A 334      20.549   1.076  -1.423  1.00 98.17           C  \\nATOM   2651  CD2 PHE A 334      19.958  -0.432  -3.234  1.00 98.17           C  \\nATOM   2652  CE1 PHE A 334      21.404   0.096  -0.893  1.00 98.17           C  \\nATOM   2653  CE2 PHE A 334      20.781  -1.428  -2.681  1.00 98.17           C  \\nATOM   2654  CZ  PHE A 334      21.510  -1.161  -1.512  1.00 98.17           C  \\nATOM   2655  N   VAL A 335      16.370   3.824  -3.606  1.00 98.49           N  \\nATOM   2656  CA  VAL A 335      15.610   4.893  -4.281  1.00 98.49           C  \\nATOM   2657  C   VAL A 335      15.489   6.109  -3.358  1.00 98.49           C  \\nATOM   2658  CB  VAL A 335      14.217   4.411  -4.743  1.00 98.49           C  \\nATOM   2659  O   VAL A 335      15.945   7.198  -3.712  1.00 98.49           O  \\nATOM   2660  CG1 VAL A 335      13.522   5.460  -5.615  1.00 98.49           C  \\nATOM   2661  CG2 VAL A 335      14.302   3.115  -5.563  1.00 98.49           C  \\nATOM   2662  N   SER A 336      15.013   5.905  -2.123  1.00 97.98           N  \\nATOM   2663  CA  SER A 336      14.899   6.980  -1.128  1.00 97.98           C  \\nATOM   2664  C   SER A 336      16.247   7.628  -0.802  1.00 97.98           C  \\nATOM   2665  CB  SER A 336      14.296   6.456   0.181  1.00 97.98           C  \\nATOM   2666  O   SER A 336      16.342   8.848  -0.676  1.00 97.98           O  \\nATOM   2667  OG  SER A 336      13.047   5.835  -0.043  1.00 97.98           O  \\nATOM   2668  N   GLN A 337      17.304   6.824  -0.666  1.00 97.83           N  \\nATOM   2669  CA  GLN A 337      18.648   7.309  -0.348  1.00 97.83           C  \\nATOM   2670  C   GLN A 337      19.269   8.113  -1.496  1.00 97.83           C  \\nATOM   2671  CB  GLN A 337      19.538   6.114   0.007  1.00 97.83           C  \\nATOM   2672  O   GLN A 337      19.897   9.136  -1.245  1.00 97.83           O  \\nATOM   2673  CG  GLN A 337      19.282   5.582   1.424  1.00 97.83           C  \\nATOM   2674  CD  GLN A 337      20.141   4.370   1.775  1.00 97.83           C  \\nATOM   2675  NE2 GLN A 337      20.156   3.967   3.026  1.00 97.83           N  \\nATOM   2676  OE1 GLN A 337      20.843   3.777   0.972  1.00 97.83           O  \\nATOM   2677  N   VAL A 338      19.078   7.681  -2.744  1.00 98.21           N  \\nATOM   2678  CA  VAL A 338      19.546   8.400  -3.935  1.00 98.21           C  \\nATOM   2679  C   VAL A 338      18.861   9.761  -4.050  1.00 98.21           C  \\nATOM   2680  CB  VAL A 338      19.325   7.539  -5.196  1.00 98.21           C  \\nATOM   2681  O   VAL A 338      19.533  10.760  -4.296  1.00 98.21           O  \\nATOM   2682  CG1 VAL A 338      19.420   8.341  -6.496  1.00 98.21           C  \\nATOM   2683  CG2 VAL A 338      20.366   6.412  -5.278  1.00 98.21           C  \\nATOM   2684  N   GLU A 339      17.547   9.832  -3.827  1.00 97.40           N  \\nATOM   2685  CA  GLU A 339      16.816  11.108  -3.869  1.00 97.40           C  \\nATOM   2686  C   GLU A 339      17.084  12.019  -2.664  1.00 97.40           C  \\nATOM   2687  CB  GLU A 339      15.312  10.857  -4.028  1.00 97.40           C  \\nATOM   2688  O   GLU A 339      16.868  13.226  -2.758  1.00 97.40           O  \\nATOM   2689  CG  GLU A 339      14.998  10.443  -5.467  1.00 97.40           C  \\nATOM   2690  CD  GLU A 339      13.502  10.504  -5.770  1.00 97.40           C  \\nATOM   2691  OE1 GLU A 339      12.998   9.538  -6.366  1.00 97.40           O  \\nATOM   2692  OE2 GLU A 339      12.828  11.535  -5.494  1.00 97.40           O  \\nATOM   2693  N   SER A 340      17.595  11.470  -1.559  1.00 96.59           N  \\nATOM   2694  CA  SER A 340      18.015  12.247  -0.384  1.00 96.59           C  \\nATOM   2695  C   SER A 340      19.433  12.823  -0.509  1.00 96.59           C  \\nATOM   2696  CB  SER A 340      17.928  11.401   0.888  1.00 96.59           C  \\nATOM   2697  O   SER A 340      19.869  13.557   0.379  1.00 96.59           O  \\nATOM   2698  OG  SER A 340      16.627  10.882   1.087  1.00 96.59           O  \\nATOM   2699  N   ASP A 341      20.172  12.502  -1.580  1.00 95.32           N  \\nATOM   2700  CA  ASP A 341      21.537  12.992  -1.779  1.00 95.32           C  \\nATOM   2701  C   ASP A 341      21.554  14.524  -1.928  1.00 95.32           C  \\nATOM   2702  CB  ASP A 341      22.202  12.281  -2.970  1.00 95.32           C  \\nATOM   2703  O   ASP A 341      20.827  15.121  -2.736  1.00 95.32           O  \\nATOM   2704  CG  ASP A 341      23.699  12.604  -3.116  1.00 95.32           C  \\nATOM   2705  OD1 ASP A 341      24.016  13.744  -3.536  1.00 95.32           O  \\nATOM   2706  OD2 ASP A 341      24.541  11.703  -2.874  1.00 95.32           O  \\nATOM   2707  N   THR A 342      22.439  15.159  -1.158  1.00 87.19           N  \\nATOM   2708  CA  THR A 342      22.571  16.620  -1.035  1.00 87.19           C  \\nATOM   2709  C   THR A 342      23.100  17.301  -2.302  1.00 87.19           C  \\nATOM   2710  CB  THR A 342      23.482  16.972   0.152  1.00 87.19           C  \\nATOM   2711  O   THR A 342      23.176  18.528  -2.353  1.00 87.19           O  \\nATOM   2712  CG2 THR A 342      22.951  16.442   1.486  1.00 87.19           C  \\nATOM   2713  OG1 THR A 342      24.759  16.408  -0.045  1.00 87.19           O  \\nATOM   2714  N   GLY A 343      23.463  16.525  -3.329  1.00 88.28           N  \\nATOM   2715  CA  GLY A 343      24.045  16.983  -4.589  1.00 88.28           C  \\nATOM   2716  C   GLY A 343      25.556  16.751  -4.680  1.00 88.28           C  \\nATOM   2717  O   GLY A 343      26.143  16.958  -5.744  1.00 88.28           O  \\nATOM   2718  N   ASP A 344      26.197  16.296  -3.596  1.00 92.51           N  \\nATOM   2719  CA  ASP A 344      27.616  15.926  -3.600  1.00 92.51           C  \\nATOM   2720  C   ASP A 344      27.880  14.522  -4.176  1.00 92.51           C  \\nATOM   2721  CB  ASP A 344      28.261  16.183  -2.224  1.00 92.51           C  \\nATOM   2722  O   ASP A 344      29.037  14.176  -4.432  1.00 92.51           O  \\nATOM   2723  CG  ASP A 344      28.088  15.097  -1.154  1.00 92.51           C  \\nATOM   2724  OD1 ASP A 344      27.431  14.068  -1.410  1.00 92.51           O  \\nATOM   2725  OD2 ASP A 344      28.753  15.256  -0.095  1.00 92.51           O  \\nATOM   2726  N   ARG A 345      26.810  13.759  -4.455  1.00 95.75           N  \\nATOM   2727  CA  ARG A 345      26.798  12.432  -5.091  1.00 95.75           C  \\nATOM   2728  C   ARG A 345      27.465  11.334  -4.270  1.00 95.75           C  \\nATOM   2729  CB  ARG A 345      27.377  12.488  -6.516  1.00 95.75           C  \\nATOM   2730  O   ARG A 345      27.610  10.220  -4.781  1.00 95.75           O  \\nATOM   2731  CG  ARG A 345      26.764  13.563  -7.421  1.00 95.75           C  \\nATOM   2732  CD  ARG A 345      27.605  13.657  -8.694  1.00 95.75           C  \\nATOM   2733  NE  ARG A 345      27.068  14.663  -9.612  1.00 95.75           N  \\nATOM   2734  NH1 ARG A 345      28.205  16.510  -8.874  1.00 95.75           N  \\nATOM   2735  NH2 ARG A 345      26.822  16.634 -10.649  1.00 95.75           N  \\nATOM   2736  CZ  ARG A 345      27.372  15.936  -9.701  1.00 95.75           C  \\nATOM   2737  N   LYS A 346      27.904  11.594  -3.034  1.00 95.92           N  \\nATOM   2738  CA  LYS A 346      28.626  10.591  -2.235  1.00 95.92           C  \\nATOM   2739  C   LYS A 346      27.734   9.415  -1.878  1.00 95.92           C  \\nATOM   2740  CB  LYS A 346      29.159  11.207  -0.942  1.00 95.92           C  \\nATOM   2741  O   LYS A 346      28.193   8.274  -1.895  1.00 95.92           O  \\nATOM   2742  CG  LYS A 346      30.309  12.184  -1.188  1.00 95.92           C  \\nATOM   2743  CD  LYS A 346      30.830  12.648   0.172  1.00 95.92           C  \\nATOM   2744  CE  LYS A 346      31.785  13.827   0.001  1.00 95.92           C  \\nATOM   2745  NZ  LYS A 346      31.323  14.949   0.842  1.00 95.92           N  \\nATOM   2746  N   GLN A 347      26.470   9.678  -1.561  1.00 96.68           N  \\nATOM   2747  CA  GLN A 347      25.531   8.630  -1.186  1.00 96.68           C  \\nATOM   2748  C   GLN A 347      25.226   7.736  -2.387  1.00 96.68           C  \\nATOM   2749  CB  GLN A 347      24.284   9.292  -0.601  1.00 96.68           C  \\nATOM   2750  O   GLN A 347      25.314   6.513  -2.280  1.00 96.68           O  \\nATOM   2751  CG  GLN A 347      23.278   8.281  -0.046  1.00 96.68           C  \\nATOM   2752  CD  GLN A 347      22.241   8.960   0.843  1.00 96.68           C  \\nATOM   2753  NE2 GLN A 347      21.460   8.205   1.576  1.00 96.68           N  \\nATOM   2754  OE1 GLN A 347      22.150  10.167   0.967  1.00 96.68           O  \\nATOM   2755  N   ILE A 348      24.983   8.352  -3.545  1.00 98.09           N  \\nATOM   2756  CA  ILE A 348      24.764   7.644  -4.812  1.00 98.09           C  \\nATOM   2757  C   ILE A 348      25.998   6.807  -5.177  1.00 98.09           C  \\nATOM   2758  CB  ILE A 348      24.400   8.641  -5.937  1.00 98.09           C  \\nATOM   2759  O   ILE A 348      25.877   5.616  -5.462  1.00 98.09           O  \\nATOM   2760  CG1 ILE A 348      23.217   9.550  -5.531  1.00 98.09           C  \\nATOM   2761  CG2 ILE A 348      24.068   7.851  -7.217  1.00 98.09           C  \\nATOM   2762  CD1 ILE A 348      22.910  10.669  -6.530  1.00 98.09           C  \\nATOM   2763  N   TYR A 349      27.196   7.395  -5.092  1.00 98.15           N  \\nATOM   2764  CA  TYR A 349      28.457   6.702  -5.365  1.00 98.15           C  \\nATOM   2765  C   TYR A 349      28.641   5.472  -4.465  1.00 98.15           C  \\nATOM   2766  CB  TYR A 349      29.629   7.682  -5.198  1.00 98.15           C  \\nATOM   2767  O   TYR A 349      29.009   4.401  -4.951  1.00 98.15           O  \\nATOM   2768  CG  TYR A 349      30.973   7.084  -5.568  1.00 98.15           C  \\nATOM   2769  CD1 TYR A 349      31.678   6.290  -4.641  1.00 98.15           C  \\nATOM   2770  CD2 TYR A 349      31.499   7.285  -6.858  1.00 98.15           C  \\nATOM   2771  CE1 TYR A 349      32.876   5.658  -5.021  1.00 98.15           C  \\nATOM   2772  CE2 TYR A 349      32.698   6.655  -7.243  1.00 98.15           C  \\nATOM   2773  OH  TYR A 349      34.527   5.197  -6.696  1.00 98.15           O  \\nATOM   2774  CZ  TYR A 349      33.382   5.830  -6.328  1.00 98.15           C  \\nATOM   2775  N   ASN A 350      28.362   5.601  -3.165  1.00 97.47           N  \\nATOM   2776  CA  ASN A 350      28.494   4.504  -2.207  1.00 97.47           C  \\nATOM   2777  C   ASN A 350      27.515   3.364  -2.504  1.00 97.47           C  \\nATOM   2778  CB  ASN A 350      28.298   5.044  -0.782  1.00 97.47           C  \\nATOM   2779  O   ASN A 350      27.929   2.208  -2.517  1.00 97.47           O  \\nATOM   2780  CG  ASN A 350      29.467   5.877  -0.290  1.00 97.47           C  \\nATOM   2781  ND2 ASN A 350      29.255   6.672   0.733  1.00 97.47           N  \\nATOM   2782  OD1 ASN A 350      30.586   5.805  -0.770  1.00 97.47           O  \\nATOM   2783  N   ILE A 351      26.248   3.674  -2.798  1.00 97.71           N  \\nATOM   2784  CA  ILE A 351      25.242   2.666  -3.169  1.00 97.71           C  \\nATOM   2785  C   ILE A 351      25.695   1.910  -4.416  1.00 97.71           C  \\nATOM   2786  CB  ILE A 351      23.864   3.332  -3.372  1.00 97.71           C  \\nATOM   2787  O   ILE A 351      25.800   0.686  -4.396  1.00 97.71           O  \\nATOM   2788  CG1 ILE A 351      23.329   3.817  -2.009  1.00 97.71           C  \\nATOM   2789  CG2 ILE A 351      22.851   2.374  -4.027  1.00 97.71           C  \\nATOM   2790  CD1 ILE A 351      22.163   4.799  -2.134  1.00 97.71           C  \\nATOM   2791  N   LEU A 352      26.057   2.621  -5.481  1.00 98.23           N  \\nATOM   2792  CA  LEU A 352      26.507   1.992  -6.723  1.00 98.23           C  \\nATOM   2793  C   LEU A 352      27.797   1.176  -6.524  1.00 98.23           C  \\nATOM   2794  CB  LEU A 352      26.670   3.096  -7.772  1.00 98.23           C  \\nATOM   2795  O   LEU A 352      27.936   0.097  -7.096  1.00 98.23           O  \\nATOM   2796  CG  LEU A 352      25.347   3.785  -8.163  1.00 98.23           C  \\nATOM   2797  CD1 LEU A 352      25.637   4.962  -9.091  1.00 98.23           C  \\nATOM   2798  CD2 LEU A 352      24.385   2.822  -8.859  1.00 98.23           C  \\nATOM   2799  N   SER A 353      28.695   1.620  -5.641  1.00 97.19           N  \\nATOM   2800  CA  SER A 353      29.888   0.853  -5.256  1.00 97.19           C  \\nATOM   2801  C   SER A 353      29.543  -0.465  -4.555  1.00 97.19           C  \\nATOM   2802  CB  SER A 353      30.812   1.679  -4.358  1.00 97.19           C  \\nATOM   2803  O   SER A 353      30.184  -1.480  -4.830  1.00 97.19           O  \\nATOM   2804  OG  SER A 353      31.270   2.841  -5.020  1.00 97.19           O  \\nATOM   2805  N   THR A 354      28.513  -0.495  -3.696  1.00 96.46           N  \\nATOM   2806  CA  THR A 354      28.027  -1.756  -3.089  1.00 96.46           C  \\nATOM   2807  C   THR A 354      27.432  -2.720  -4.113  1.00 96.46           C  \\nATOM   2808  CB  THR A 354      27.016  -1.554  -1.948  1.00 96.46           C  \\nATOM   2809  O   THR A 354      27.486  -3.931  -3.916  1.00 96.46           O  \\nATOM   2810  CG2 THR A 354      27.591  -0.755  -0.785  1.00 96.46           C  \\nATOM   2811  OG1 THR A 354      25.813  -0.930  -2.316  1.00 96.46           O  \\nATOM   2812  N   LEU A 355      26.956  -2.200  -5.246  1.00 96.99           N  \\nATOM   2813  CA  LEU A 355      26.518  -2.983  -6.400  1.00 96.99           C  \\nATOM   2814  C   LEU A 355      27.678  -3.339  -7.343  1.00 96.99           C  \\nATOM   2815  CB  LEU A 355      25.376  -2.241  -7.119  1.00 96.99           C  \\nATOM   2816  O   LEU A 355      27.434  -3.759  -8.465  1.00 96.99           O  \\nATOM   2817  CG  LEU A 355      24.112  -2.043  -6.262  1.00 96.99           C  \\nATOM   2818  CD1 LEU A 355      23.136  -1.131  -7.002  1.00 96.99           C  \\nATOM   2819  CD2 LEU A 355      23.409  -3.370  -5.971  1.00 96.99           C  \\nATOM   2820  N   GLY A 356      28.940  -3.181  -6.936  1.00 96.65           N  \\nATOM   2821  CA  GLY A 356      30.102  -3.558  -7.749  1.00 96.65           C  \\nATOM   2822  C   GLY A 356      30.396  -2.616  -8.922  1.00 96.65           C  \\nATOM   2823  O   GLY A 356      31.134  -2.996  -9.829  1.00 96.65           O  \\nATOM   2824  N   LEU A 357      29.838  -1.403  -8.922  1.00 96.66           N  \\nATOM   2825  CA  LEU A 357      30.019  -0.410  -9.984  1.00 96.66           C  \\nATOM   2826  C   LEU A 357      31.025   0.670  -9.561  1.00 96.66           C  \\nATOM   2827  CB  LEU A 357      28.656   0.199 -10.357  1.00 96.66           C  \\nATOM   2828  O   LEU A 357      31.198   0.960  -8.380  1.00 96.66           O  \\nATOM   2829  CG  LEU A 357      27.621  -0.835 -10.844  1.00 96.66           C  \\nATOM   2830  CD1 LEU A 357      26.217  -0.272 -10.668  1.00 96.66           C  \\nATOM   2831  CD2 LEU A 357      27.847  -1.199 -12.311  1.00 96.66           C  \\nATOM   2832  N   ARG A 358      31.679   1.307 -10.536  1.00 94.44           N  \\nATOM   2833  CA  ARG A 358      32.534   2.489 -10.324  1.00 94.44           C  \\nATOM   2834  C   ARG A 358      31.951   3.668 -11.104  1.00 94.44           C  \\nATOM   2835  CB  ARG A 358      33.983   2.190 -10.727  1.00 94.44           C  \\nATOM   2836  O   ARG A 358      32.379   3.903 -12.233  1.00 94.44           O  \\nATOM   2837  CG  ARG A 358      34.644   1.181  -9.784  1.00 94.44           C  \\nATOM   2838  CD  ARG A 358      36.095   0.975 -10.220  1.00 94.44           C  \\nATOM   2839  NE  ARG A 358      36.766  -0.035  -9.385  1.00 94.44           N  \\nATOM   2840  NH1 ARG A 358      38.642  -0.266 -10.683  1.00 94.44           N  \\nATOM   2841  NH2 ARG A 358      38.407  -1.515  -8.846  1.00 94.44           N  \\nATOM   2842  CZ  ARG A 358      37.932  -0.597  -9.639  1.00 94.44           C  \\nATOM   2843  N   PRO A 359      30.939   4.359 -10.557  1.00 95.90           N  \\nATOM   2844  CA  PRO A 359      30.183   5.345 -11.316  1.00 95.90           C  \\nATOM   2845  C   PRO A 359      30.984   6.634 -11.532  1.00 95.90           C  \\nATOM   2846  CB  PRO A 359      28.918   5.582 -10.493  1.00 95.90           C  \\nATOM   2847  O   PRO A 359      31.688   7.112 -10.639  1.00 95.90           O  \\nATOM   2848  CG  PRO A 359      29.421   5.399  -9.066  1.00 95.90           C  \\nATOM   2849  CD  PRO A 359      30.406   4.241  -9.202  1.00 95.90           C  \\nATOM   2850  N   SER A 360      30.835   7.232 -12.712  1.00 95.35           N  \\nATOM   2851  CA  SER A 360      31.219   8.625 -12.943  1.00 95.35           C  \\nATOM   2852  C   SER A 360      30.215   9.587 -12.293  1.00 95.35           C  \\nATOM   2853  CB  SER A 360      31.350   8.894 -14.446  1.00 95.35           C  \\nATOM   2854  O   SER A 360      29.111   9.202 -11.905  1.00 95.35           O  \\nATOM   2855  OG  SER A 360      30.088   8.869 -15.078  1.00 95.35           O  \\nATOM   2856  N   THR A 361      30.556  10.877 -12.223  1.00 94.67           N  \\nATOM   2857  CA  THR A 361      29.615  11.913 -11.760  1.00 94.67           C  \\nATOM   2858  C   THR A 361      28.344  11.952 -12.605  1.00 94.67           C  \\nATOM   2859  CB  THR A 361      30.263  13.304 -11.791  1.00 94.67           C  \\nATOM   2860  O   THR A 361      27.255  12.113 -12.065  1.00 94.67           O  \\nATOM   2861  CG2 THR A 361      31.375  13.423 -10.750  1.00 94.67           C  \\nATOM   2862  OG1 THR A 361      30.851  13.554 -13.053  1.00 94.67           O  \\nATOM   2863  N   THR A 362      28.481  11.760 -13.920  1.00 94.45           N  \\nATOM   2864  CA  THR A 362      27.354  11.707 -14.854  1.00 94.45           C  \\nATOM   2865  C   THR A 362      26.495  10.469 -14.624  1.00 94.45           C  \\nATOM   2866  CB  THR A 362      27.868  11.719 -16.300  1.00 94.45           C  \\nATOM   2867  O   THR A 362      25.277  10.572 -14.697  1.00 94.45           O  \\nATOM   2868  CG2 THR A 362      26.753  11.787 -17.342  1.00 94.45           C  \\nATOM   2869  OG1 THR A 362      28.689  12.847 -16.503  1.00 94.45           O  \\nATOM   2870  N   ASP A 363      27.092   9.317 -14.308  1.00 97.00           N  \\nATOM   2871  CA  ASP A 363      26.313   8.115 -13.993  1.00 97.00           C  \\nATOM   2872  C   ASP A 363      25.495   8.304 -12.709  1.00 97.00           C  \\nATOM   2873  CB  ASP A 363      27.206   6.880 -13.857  1.00 97.00           C  \\nATOM   2874  O   ASP A 363      24.325   7.933 -12.675  1.00 97.00           O  \\nATOM   2875  CG  ASP A 363      28.017   6.552 -15.109  1.00 97.00           C  \\nATOM   2876  OD1 ASP A 363      27.462   6.527 -16.232  1.00 97.00           O  \\nATOM   2877  OD2 ASP A 363      29.243   6.370 -14.938  1.00 97.00           O  \\nATOM   2878  N   CYS A 364      26.065   8.944 -11.679  1.00 97.84           N  \\nATOM   2879  CA  CYS A 364      25.316   9.287 -10.467  1.00 97.84           C  \\nATOM   2880  C   CYS A 364      24.115  10.198 -10.771  1.00 97.84           C  \\nATOM   2881  CB  CYS A 364      26.235   9.971  -9.446  1.00 97.84           C  \\nATOM   2882  O   CYS A 364      23.026   9.966 -10.248  1.00 97.84           O  \\nATOM   2883  SG  CYS A 364      27.482   8.823  -8.792  1.00 97.84           S  \\nATOM   2884  N   ASP A 365      24.298  11.204 -11.632  1.00 96.57           N  \\nATOM   2885  CA  ASP A 365      23.218  12.114 -12.029  1.00 96.57           C  \\nATOM   2886  C   ASP A 365      22.114  11.366 -12.800  1.00 96.57           C  \\nATOM   2887  CB  ASP A 365      23.786  13.295 -12.845  1.00 96.57           C  \\nATOM   2888  O   ASP A 365      20.932  11.572 -12.538  1.00 96.57           O  \\nATOM   2889  CG  ASP A 365      24.688  14.246 -12.036  1.00 96.57           C  \\nATOM   2890  OD1 ASP A 365      24.616  14.263 -10.790  1.00 96.57           O  \\nATOM   2891  OD2 ASP A 365      25.488  15.011 -12.627  1.00 96.57           O  \\nATOM   2892  N   ILE A 366      22.476  10.441 -13.695  1.00 97.98           N  \\nATOM   2893  CA  ILE A 366      21.510   9.618 -14.442  1.00 97.98           C  \\nATOM   2894  C   ILE A 366      20.736   8.680 -13.506  1.00 97.98           C  \\nATOM   2895  CB  ILE A 366      22.225   8.843 -15.570  1.00 97.98           C  \\nATOM   2896  O   ILE A 366      19.514   8.591 -13.610  1.00 97.98           O  \\nATOM   2897  CG1 ILE A 366      22.737   9.823 -16.651  1.00 97.98           C  \\nATOM   2898  CG2 ILE A 366      21.282   7.807 -16.209  1.00 97.98           C  \\nATOM   2899  CD1 ILE A 366      23.715   9.190 -17.646  1.00 97.98           C  \\nATOM   2900  N   VAL A 367      21.414   8.017 -12.563  1.00 98.54           N  \\nATOM   2901  CA  VAL A 367      20.761   7.141 -11.572  1.00 98.54           C  \\nATOM   2902  C   VAL A 367      19.773   7.930 -10.719  1.00 98.54           C  \\nATOM   2903  CB  VAL A 367      21.808   6.433 -10.692  1.00 98.54           C  \\nATOM   2904  O   VAL A 367      18.657   7.468 -10.492  1.00 98.54           O  \\nATOM   2905  CG1 VAL A 367      21.197   5.704  -9.486  1.00 98.54           C  \\nATOM   2906  CG2 VAL A 367      22.559   5.387 -11.522  1.00 98.54           C  \\nATOM   2907  N   ARG A 368      20.139   9.150 -10.306  1.00 98.12           N  \\nATOM   2908  CA  ARG A 368      19.220  10.052  -9.604  1.00 98.12           C  \\nATOM   2909  C   ARG A 368      17.973  10.346 -10.432  1.00 98.12           C  \\nATOM   2910  CB  ARG A 368      19.963  11.330  -9.203  1.00 98.12           C  \\nATOM   2911  O   ARG A 368      16.867  10.208  -9.918  1.00 98.12           O  \\nATOM   2912  CG  ARG A 368      19.072  12.262  -8.378  1.00 98.12           C  \\nATOM   2913  CD  ARG A 368      19.839  13.530  -8.013  1.00 98.12           C  \\nATOM   2914  NE  ARG A 368      18.976  14.444  -7.250  1.00 98.12           N  \\nATOM   2915  NH1 ARG A 368      20.544  15.197  -5.731  1.00 98.12           N  \\nATOM   2916  NH2 ARG A 368      18.407  15.731  -5.473  1.00 98.12           N  \\nATOM   2917  CZ  ARG A 368      19.317  15.126  -6.172  1.00 98.12           C  \\nATOM   2918  N   ARG A 369      18.138  10.691 -11.711  1.00 97.78           N  \\nATOM   2919  CA  ARG A 369      17.013  10.969 -12.619  1.00 97.78           C  \\nATOM   2920  C   ARG A 369      16.116   9.748 -12.830  1.00 97.78           C  \\nATOM   2921  CB  ARG A 369      17.541  11.503 -13.962  1.00 97.78           C  \\nATOM   2922  O   ARG A 369      14.897   9.906 -12.881  1.00 97.78           O  \\nATOM   2923  CG  ARG A 369      18.216  12.881 -13.872  1.00 97.78           C  \\nATOM   2924  CD  ARG A 369      17.252  14.011 -13.517  1.00 97.78           C  \\nATOM   2925  NE  ARG A 369      16.293  14.269 -14.605  1.00 97.78           N  \\nATOM   2926  NH1 ARG A 369      14.565  15.005 -13.275  1.00 97.78           N  \\nATOM   2927  NH2 ARG A 369      14.344  14.912 -15.526  1.00 97.78           N  \\nATOM   2928  CZ  ARG A 369      15.070  14.728 -14.456  1.00 97.78           C  \\nATOM   2929  N   ALA A 370      16.683   8.544 -12.904  1.00 98.71           N  \\nATOM   2930  CA  ALA A 370      15.912   7.305 -12.997  1.00 98.71           C  \\nATOM   2931  C   ALA A 370      15.062   7.065 -11.736  1.00 98.71           C  \\nATOM   2932  CB  ALA A 370      16.866   6.141 -13.289  1.00 98.71           C  \\nATOM   2933  O   ALA A 370      13.857   6.840 -11.853  1.00 98.71           O  \\nATOM   2934  N   CYS A 371      15.654   7.198 -10.541  1.00 98.71           N  \\nATOM   2935  CA  CYS A 371      14.924   7.123  -9.269  1.00 98.71           C  \\nATOM   2936  C   CYS A 371      13.780   8.148  -9.208  1.00 98.71           C  \\nATOM   2937  CB  CYS A 371      15.894   7.338  -8.098  1.00 98.71           C  \\nATOM   2938  O   CYS A 371      12.632   7.763  -8.988  1.00 98.71           O  \\nATOM   2939  SG  CYS A 371      16.998   5.911  -7.895  1.00 98.71           S  \\nATOM   2940  N   GLU A 372      14.083   9.421  -9.498  1.00 98.25           N  \\nATOM   2941  CA  GLU A 372      13.103  10.515  -9.503  1.00 98.25           C  \\nATOM   2942  C   GLU A 372      11.940  10.244 -10.462  1.00 98.25           C  \\nATOM   2943  CB  GLU A 372      13.785  11.841  -9.899  1.00 98.25           C  \\nATOM   2944  O   GLU A 372      10.793  10.547 -10.137  1.00 98.25           O  \\nATOM   2945  CG  GLU A 372      14.665  12.455  -8.795  1.00 98.25           C  \\nATOM   2946  CD  GLU A 372      15.472  13.693  -9.252  1.00 98.25           C  \\nATOM   2947  OE1 GLU A 372      16.250  14.217  -8.409  1.00 98.25           O  \\nATOM   2948  OE2 GLU A 372      15.337  14.122 -10.431  1.00 98.25           O  \\nATOM   2949  N   SER A 373      12.212   9.667 -11.634  1.00 98.67           N  \\nATOM   2950  CA  SER A 373      11.188   9.380 -12.645  1.00 98.67           C  \\nATOM   2951  C   SER A 373      10.227   8.285 -12.176  1.00 98.67           C  \\nATOM   2952  CB  SER A 373      11.845   8.999 -13.975  1.00 98.67           C  \\nATOM   2953  O   SER A 373       9.009   8.467 -12.228  1.00 98.67           O  \\nATOM   2954  OG  SER A 373      12.676  10.057 -14.414  1.00 98.67           O  \\nATOM   2955  N   VAL A 374      10.760   7.183 -11.637  1.00 98.79           N  \\nATOM   2956  CA  VAL A 374       9.952   6.068 -11.118  1.00 98.79           C  \\nATOM   2957  C   VAL A 374       9.122   6.505  -9.908  1.00 98.79           C  \\nATOM   2958  CB  VAL A 374      10.841   4.856 -10.768  1.00 98.79           C  \\nATOM   2959  O   VAL A 374       7.913   6.266  -9.874  1.00 98.79           O  \\nATOM   2960  CG1 VAL A 374      10.036   3.714 -10.132  1.00 98.79           C  \\nATOM   2961  CG2 VAL A 374      11.514   4.283 -12.022  1.00 98.79           C  \\nATOM   2962  N   SER A 375       9.735   7.180  -8.931  1.00 98.58           N  \\nATOM   2963  CA  SER A 375       9.045   7.597  -7.705  1.00 98.58           C  \\nATOM   2964  C   SER A 375       8.007   8.698  -7.964  1.00 98.58           C  \\nATOM   2965  CB  SER A 375      10.065   8.052  -6.662  1.00 98.58           C  \\nATOM   2966  O   SER A 375       6.941   8.698  -7.346  1.00 98.58           O  \\nATOM   2967  OG  SER A 375      10.607   9.287  -7.064  1.00 98.58           O  \\nATOM   2968  N   THR A 376       8.263   9.608  -8.914  1.00 98.64           N  \\nATOM   2969  CA  THR A 376       7.288  10.626  -9.340  1.00 98.64           C  \\nATOM   2970  C   THR A 376       6.085   9.982 -10.015  1.00 98.64           C  \\nATOM   2971  CB  THR A 376       7.910  11.668 -10.279  1.00 98.64           C  \\nATOM   2972  O   THR A 376       4.952  10.313  -9.665  1.00 98.64           O  \\nATOM   2973  CG2 THR A 376       6.918  12.742 -10.726  1.00 98.64           C  \\nATOM   2974  OG1 THR A 376       8.946  12.332  -9.601  1.00 98.64           O  \\nATOM   2975  N   ARG A 377       6.304   9.023 -10.925  1.00 98.72           N  \\nATOM   2976  CA  ARG A 377       5.209   8.274 -11.553  1.00 98.72           C  \\nATOM   2977  C   ARG A 377       4.373   7.533 -10.510  1.00 98.72           C  \\nATOM   2978  CB  ARG A 377       5.777   7.311 -12.601  1.00 98.72           C  \\nATOM   2979  O   ARG A 377       3.151   7.622 -10.553  1.00 98.72           O  \\nATOM   2980  CG  ARG A 377       4.652   6.676 -13.438  1.00 98.72           C  \\nATOM   2981  CD  ARG A 377       5.182   5.602 -14.387  1.00 98.72           C  \\nATOM   2982  NE  ARG A 377       5.740   4.459 -13.640  1.00 98.72           N  \\nATOM   2983  NH1 ARG A 377       5.807   2.958 -15.370  1.00 98.72           N  \\nATOM   2984  NH2 ARG A 377       6.399   2.325 -13.327  1.00 98.72           N  \\nATOM   2985  CZ  ARG A 377       5.988   3.260 -14.124  1.00 98.72           C  \\nATOM   2986  N   ALA A 378       5.012   6.871  -9.544  1.00 98.75           N  \\nATOM   2987  CA  ALA A 378       4.325   6.191  -8.445  1.00 98.75           C  \\nATOM   2988  C   ALA A 378       3.463   7.159  -7.611  1.00 98.75           C  \\nATOM   2989  CB  ALA A 378       5.382   5.488  -7.585  1.00 98.75           C  \\nATOM   2990  O   ALA A 378       2.293   6.877  -7.348  1.00 98.75           O  \\nATOM   2991  N   ALA A 379       4.001   8.330  -7.247  1.00 98.78           N  \\nATOM   2992  CA  ALA A 379       3.260   9.357  -6.513  1.00 98.78           C  \\nATOM   2993  C   ALA A 379       2.065   9.897  -7.316  1.00 98.78           C  \\nATOM   2994  CB  ALA A 379       4.230  10.483  -6.130  1.00 98.78           C  \\nATOM   2995  O   ALA A 379       0.981  10.097  -6.764  1.00 98.78           O  \\nATOM   2996  N   HIS A 380       2.242  10.103  -8.622  1.00 98.81           N  \\nATOM   2997  CA  HIS A 380       1.180  10.556  -9.515  1.00 98.81           C  \\nATOM   2998  C   HIS A 380       0.085   9.503  -9.704  1.00 98.81           C  \\nATOM   2999  CB  HIS A 380       1.779  10.962 -10.863  1.00 98.81           C  \\nATOM   3000  O   HIS A 380      -1.090   9.841  -9.561  1.00 98.81           O  \\nATOM   3001  CG  HIS A 380       2.546  12.259 -10.876  1.00 98.81           C  \\nATOM   3002  CD2 HIS A 380       2.715  13.154  -9.850  1.00 98.81           C  \\nATOM   3003  ND1 HIS A 380       3.147  12.803 -11.986  1.00 98.81           N  \\nATOM   3004  CE1 HIS A 380       3.672  13.988 -11.638  1.00 98.81           C  \\nATOM   3005  NE2 HIS A 380       3.424  14.256 -10.344  1.00 98.81           N  \\nATOM   3006  N   MET A 381       0.441   8.237  -9.941  1.00 98.71           N  \\nATOM   3007  CA  MET A 381      -0.532   7.144 -10.011  1.00 98.71           C  \\nATOM   3008  C   MET A 381      -1.320   7.073  -8.705  1.00 98.71           C  \\nATOM   3009  CB  MET A 381       0.153   5.808 -10.351  1.00 98.71           C  \\nATOM   3010  O   MET A 381      -2.526   7.284  -8.731  1.00 98.71           O  \\nATOM   3011  CG  MET A 381       0.622   5.767 -11.812  1.00 98.71           C  \\nATOM   3012  SD  MET A 381      -0.717   5.914 -13.030  1.00 98.71           S  \\nATOM   3013  CE  MET A 381      -1.249   4.191 -13.186  1.00 98.71           C  \\nATOM   3014  N   CYS A 382      -0.641   6.971  -7.556  1.00 98.75           N  \\nATOM   3015  CA  CYS A 382      -1.277   6.977  -6.235  1.00 98.75           C  \\nATOM   3016  C   CYS A 382      -2.235   8.168  -6.037  1.00 98.75           C  \\nATOM   3017  CB  CYS A 382      -0.158   6.984  -5.184  1.00 98.75           C  \\nATOM   3018  O   CYS A 382      -3.330   8.001  -5.497  1.00 98.75           O  \\nATOM   3019  SG  CYS A 382      -0.828   6.691  -3.523  1.00 98.75           S  \\nATOM   3020  N   SER A 383      -1.853   9.367  -6.500  1.00 98.84           N  \\nATOM   3021  CA  SER A 383      -2.701  10.562  -6.416  1.00 98.84           C  \\nATOM   3022  C   SER A 383      -3.982  10.458  -7.241  1.00 98.84           C  \\nATOM   3023  CB  SER A 383      -1.929  11.824  -6.807  1.00 98.84           C  \\nATOM   3024  O   SER A 383      -5.022  10.918  -6.781  1.00 98.84           O  \\nATOM   3025  OG  SER A 383      -1.737  11.972  -8.201  1.00 98.84           O  \\nATOM   3026  N   ALA A 384      -3.928   9.835  -8.422  1.00 98.81           N  \\nATOM   3027  CA  ALA A 384      -5.092   9.650  -9.279  1.00 98.81           C  \\nATOM   3028  C   ALA A 384      -6.100   8.674  -8.658  1.00 98.81           C  \\nATOM   3029  CB  ALA A 384      -4.617   9.192 -10.662  1.00 98.81           C  \\nATOM   3030  O   ALA A 384      -7.302   8.930  -8.709  1.00 98.81           O  \\nATOM   3031  N   GLY A 385      -5.618   7.608  -8.010  1.00 98.76           N  \\nATOM   3032  CA  GLY A 385      -6.468   6.691  -7.244  1.00 98.76           C  \\nATOM   3033  C   GLY A 385      -7.174   7.382  -6.082  1.00 98.76           C  \\nATOM   3034  O   GLY A 385      -8.400   7.330  -5.997  1.00 98.76           O  \\nATOM   3035  N   LEU A 386      -6.427   8.098  -5.226  1.00 98.83           N  \\nATOM   3036  CA  LEU A 386      -7.032   8.837  -4.111  1.00 98.83           C  \\nATOM   3037  C   LEU A 386      -8.006   9.914  -4.606  1.00 98.83           C  \\nATOM   3038  CB  LEU A 386      -5.948   9.452  -3.205  1.00 98.83           C  \\nATOM   3039  O   LEU A 386      -9.088  10.062  -4.044  1.00 98.83           O  \\nATOM   3040  CG  LEU A 386      -6.561  10.303  -2.069  1.00 98.83           C  \\nATOM   3041  CD1 LEU A 386      -7.463   9.489  -1.138  1.00 98.83           C  \\nATOM   3042  CD2 LEU A 386      -5.492  10.997  -1.234  1.00 98.83           C  \\nATOM   3043  N   ALA A 387      -7.654  10.652  -5.659  1.00 98.76           N  \\nATOM   3044  CA  ALA A 387      -8.555  11.638  -6.244  1.00 98.76           C  \\nATOM   3045  C   ALA A 387      -9.857  10.993  -6.743  1.00 98.76           C  \\nATOM   3046  CB  ALA A 387      -7.828  12.376  -7.368  1.00 98.76           C  \\nATOM   3047  O   ALA A 387     -10.919  11.588  -6.592  1.00 98.76           O  \\nATOM   3048  N   GLY A 388      -9.793   9.766  -7.275  1.00 98.53           N  \\nATOM   3049  CA  GLY A 388     -10.974   8.996  -7.663  1.00 98.53           C  \\nATOM   3050  C   GLY A 388     -11.880   8.694  -6.469  1.00 98.53           C  \\nATOM   3051  O   GLY A 388     -13.083   8.936  -6.541  1.00 98.53           O  \\nATOM   3052  N   VAL A 389     -11.294   8.259  -5.349  1.00 98.67           N  \\nATOM   3053  CA  VAL A 389     -12.026   8.021  -4.092  1.00 98.67           C  \\nATOM   3054  C   VAL A 389     -12.666   9.307  -3.567  1.00 98.67           C  \\nATOM   3055  CB  VAL A 389     -11.109   7.382  -3.027  1.00 98.67           C  \\nATOM   3056  O   VAL A 389     -13.866   9.341  -3.315  1.00 98.67           O  \\nATOM   3057  CG1 VAL A 389     -11.791   7.253  -1.659  1.00 98.67           C  \\nATOM   3058  CG2 VAL A 389     -10.669   5.976  -3.451  1.00 98.67           C  \\nATOM   3059  N   ILE A 390     -11.897  10.388  -3.452  1.00 98.50           N  \\nATOM   3060  CA  ILE A 390     -12.374  11.659  -2.890  1.00 98.50           C  \\nATOM   3061  C   ILE A 390     -13.462  12.286  -3.768  1.00 98.50           C  \\nATOM   3062  CB  ILE A 390     -11.170  12.601  -2.669  1.00 98.50           C  \\nATOM   3063  O   ILE A 390     -14.488  12.724  -3.251  1.00 98.50           O  \\nATOM   3064  CG1 ILE A 390     -10.322  12.057  -1.496  1.00 98.50           C  \\nATOM   3065  CG2 ILE A 390     -11.584  14.055  -2.393  1.00 98.50           C  \\nATOM   3066  CD1 ILE A 390      -9.079  12.892  -1.183  1.00 98.50           C  \\nATOM   3067  N   ASN A 391     -13.280  12.312  -5.092  1.00 97.99           N  \\nATOM   3068  CA  ASN A 391     -14.293  12.860  -5.992  1.00 97.99           C  \\nATOM   3069  C   ASN A 391     -15.575  12.021  -5.963  1.00 97.99           C  \\nATOM   3070  CB  ASN A 391     -13.725  13.012  -7.411  1.00 97.99           C  \\nATOM   3071  O   ASN A 391     -16.655  12.603  -5.922  1.00 97.99           O  \\nATOM   3072  CG  ASN A 391     -12.769  14.188  -7.546  1.00 97.99           C  \\nATOM   3073  ND2 ASN A 391     -11.775  14.080  -8.396  1.00 97.99           N  \\nATOM   3074  OD1 ASN A 391     -12.906  15.233  -6.924  1.00 97.99           O  \\nATOM   3075  N   ARG A 392     -15.472  10.685  -5.871  1.00 96.58           N  \\nATOM   3076  CA  ARG A 392     -16.637   9.819  -5.643  1.00 96.58           C  \\nATOM   3077  C   ARG A 392     -17.382  10.204  -4.365  1.00 96.58           C  \\nATOM   3078  CB  ARG A 392     -16.204   8.346  -5.587  1.00 96.58           C  \\nATOM   3079  O   ARG A 392     -18.593  10.376  -4.417  1.00 96.58           O  \\nATOM   3080  CG  ARG A 392     -17.398   7.442  -5.262  1.00 96.58           C  \\nATOM   3081  CD  ARG A 392     -16.968   6.000  -5.001  1.00 96.58           C  \\nATOM   3082  NE  ARG A 392     -18.160   5.151  -4.868  1.00 96.58           N  \\nATOM   3083  NH1 ARG A 392     -18.564   5.064  -7.100  1.00 96.58           N  \\nATOM   3084  NH2 ARG A 392     -20.104   4.293  -5.731  1.00 96.58           N  \\nATOM   3085  CZ  ARG A 392     -18.933   4.825  -5.882  1.00 96.58           C  \\nATOM   3086  N   MET A 393     -16.678  10.328  -3.238  1.00 96.86           N  \\nATOM   3087  CA  MET A 393     -17.297  10.677  -1.952  1.00 96.86           C  \\nATOM   3088  C   MET A 393     -18.008  12.031  -2.019  1.00 96.86           C  \\nATOM   3089  CB  MET A 393     -16.233  10.731  -0.851  1.00 96.86           C  \\nATOM   3090  O   MET A 393     -19.142  12.168  -1.569  1.00 96.86           O  \\nATOM   3091  CG  MET A 393     -15.652   9.361  -0.507  1.00 96.86           C  \\nATOM   3092  SD  MET A 393     -14.265   9.454   0.656  1.00 96.86           S  \\nATOM   3093  CE  MET A 393     -15.188   9.799   2.178  1.00 96.86           C  \\nATOM   3094  N   ARG A 394     -17.366  13.030  -2.632  1.00 96.82           N  \\nATOM   3095  CA  ARG A 394     -17.969  14.349  -2.844  1.00 96.82           C  \\nATOM   3096  C   ARG A 394     -19.245  14.253  -3.686  1.00 96.82           C  \\nATOM   3097  CB  ARG A 394     -16.921  15.259  -3.500  1.00 96.82           C  \\nATOM   3098  O   ARG A 394     -20.254  14.871  -3.355  1.00 96.82           O  \\nATOM   3099  CG  ARG A 394     -17.499  16.644  -3.798  1.00 96.82           C  \\nATOM   3100  CD  ARG A 394     -16.545  17.487  -4.640  1.00 96.82           C  \\nATOM   3101  NE  ARG A 394     -17.291  18.600  -5.247  1.00 96.82           N  \\nATOM   3102  NH1 ARG A 394     -17.548  17.748  -7.372  1.00 96.82           N  \\nATOM   3103  NH2 ARG A 394     -18.596  19.636  -6.760  1.00 96.82           N  \\nATOM   3104  CZ  ARG A 394     -17.800  18.652  -6.461  1.00 96.82           C  \\nATOM   3105  N   GLU A 395     -19.184  13.512  -4.791  1.00 95.18           N  \\nATOM   3106  CA  GLU A 395     -20.299  13.333  -5.724  1.00 95.18           C  \\nATOM   3107  C   GLU A 395     -21.468  12.584  -5.074  1.00 95.18           C  \\nATOM   3108  CB  GLU A 395     -19.805  12.596  -6.984  1.00 95.18           C  \\nATOM   3109  O   GLU A 395     -22.609  13.030  -5.196  1.00 95.18           O  \\nATOM   3110  CG  GLU A 395     -18.950  13.494  -7.899  1.00 95.18           C  \\nATOM   3111  CD  GLU A 395     -18.091  12.723  -8.922  1.00 95.18           C  \\nATOM   3112  OE1 GLU A 395     -17.265  13.389  -9.592  1.00 95.18           O  \\nATOM   3113  OE2 GLU A 395     -18.231  11.487  -9.059  1.00 95.18           O  \\nATOM   3114  N   SER A 396     -21.202  11.506  -4.329  1.00 92.50           N  \\nATOM   3115  CA  SER A 396     -22.244  10.727  -3.647  1.00 92.50           C  \\nATOM   3116  C   SER A 396     -22.952  11.529  -2.554  1.00 92.50           C  \\nATOM   3117  CB  SER A 396     -21.681   9.416  -3.083  1.00 92.50           C  \\nATOM   3118  O   SER A 396     -24.162  11.390  -2.377  1.00 92.50           O  \\nATOM   3119  OG  SER A 396     -20.777   9.613  -2.015  1.00 92.50           O  \\nATOM   3120  N   ARG A 397     -22.230  12.431  -1.881  1.00 93.70           N  \\nATOM   3121  CA  ARG A 397     -22.770  13.331  -0.849  1.00 93.70           C  \\nATOM   3122  C   ARG A 397     -23.376  14.618  -1.398  1.00 93.70           C  \\nATOM   3123  CB  ARG A 397     -21.673  13.633   0.171  1.00 93.70           C  \\nATOM   3124  O   ARG A 397     -23.945  15.395  -0.637  1.00 93.70           O  \\nATOM   3125  CG  ARG A 397     -21.259  12.356   0.904  1.00 93.70           C  \\nATOM   3126  CD  ARG A 397     -20.071  12.671   1.793  1.00 93.70           C  \\nATOM   3127  NE  ARG A 397     -19.587  11.441   2.426  1.00 93.70           N  \\nATOM   3128  NH1 ARG A 397     -17.913  12.459   3.596  1.00 93.70           N  \\nATOM   3129  NH2 ARG A 397     -18.142  10.259   3.718  1.00 93.70           N  \\nATOM   3130  CZ  ARG A 397     -18.555  11.388   3.231  1.00 93.70           C  \\nATOM   3131  N   SER A 398     -23.291  14.844  -2.712  1.00 93.17           N  \\nATOM   3132  CA  SER A 398     -23.761  16.074  -3.365  1.00 93.17           C  \\nATOM   3133  C   SER A 398     -23.169  17.349  -2.744  1.00 93.17           C  \\nATOM   3134  CB  SER A 398     -25.294  16.109  -3.417  1.00 93.17           C  \\nATOM   3135  O   SER A 398     -23.855  18.362  -2.603  1.00 93.17           O  \\nATOM   3136  OG  SER A 398     -25.784  14.977  -4.113  1.00 93.17           O  \\nATOM   3137  N   GLU A 399     -21.892  17.303  -2.360  1.00 92.50           N  \\nATOM   3138  CA  GLU A 399     -21.207  18.432  -1.730  1.00 92.50           C  \\nATOM   3139  C   GLU A 399     -20.519  19.328  -2.770  1.00 92.50           C  \\nATOM   3140  CB  GLU A 399     -20.208  17.947  -0.670  1.00 92.50           C  \\nATOM   3141  O   GLU A 399     -19.718  18.879  -3.596  1.00 92.50           O  \\nATOM   3142  CG  GLU A 399     -20.916  17.390   0.578  1.00 92.50           C  \\nATOM   3143  CD  GLU A 399     -19.939  16.929   1.672  1.00 92.50           C  \\nATOM   3144  OE1 GLU A 399     -20.399  16.285   2.642  1.00 92.50           O  \\nATOM   3145  OE2 GLU A 399     -18.733  17.233   1.553  1.00 92.50           O  \\nATOM   3146  N   ASP A 400     -20.780  20.636  -2.709  1.00 92.82           N  \\nATOM   3147  CA  ASP A 400     -20.091  21.602  -3.570  1.00 92.82           C  \\nATOM   3148  C   ASP A 400     -18.598  21.674  -3.233  1.00 92.82           C  \\nATOM   3149  CB  ASP A 400     -20.731  22.992  -3.445  1.00 92.82           C  \\nATOM   3150  O   ASP A 400     -17.759  21.562  -4.133  1.00 92.82           O  \\nATOM   3151  CG  ASP A 400     -22.056  23.126  -4.198  1.00 92.82           C  \\nATOM   3152  OD1 ASP A 400     -22.203  22.466  -5.251  1.00 92.82           O  \\nATOM   3153  OD2 ASP A 400     -22.873  23.962  -3.752  1.00 92.82           O  \\nATOM   3154  N   VAL A 401     -18.286  21.803  -1.938  1.00 94.77           N  \\nATOM   3155  CA  VAL A 401     -16.934  21.766  -1.370  1.00 94.77           C  \\nATOM   3156  C   VAL A 401     -16.911  20.767  -0.220  1.00 94.77           C  \\nATOM   3157  CB  VAL A 401     -16.463  23.152  -0.882  1.00 94.77           C  \\nATOM   3158  O   VAL A 401     -17.601  20.978   0.776  1.00 94.77           O  \\nATOM   3159  CG1 VAL A 401     -15.048  23.087  -0.285  1.00 94.77           C  \\nATOM   3160  CG2 VAL A 401     -16.439  24.170  -2.030  1.00 94.77           C  \\nATOM   3161  N   MET A 402     -16.094  19.722  -0.345  1.00 96.08           N  \\nATOM   3162  CA  MET A 402     -15.943  18.694   0.689  1.00 96.08           C  \\nATOM   3163  C   MET A 402     -14.693  18.952   1.530  1.00 96.08           C  \\nATOM   3164  CB  MET A 402     -15.939  17.298   0.049  1.00 96.08           C  \\nATOM   3165  O   MET A 402     -13.603  19.158   0.990  1.00 96.08           O  \\nATOM   3166  CG  MET A 402     -15.830  16.175   1.090  1.00 96.08           C  \\nATOM   3167  SD  MET A 402     -16.066  14.506   0.424  1.00 96.08           S  \\nATOM   3168  CE  MET A 402     -14.486  14.324  -0.423  1.00 96.08           C  \\nATOM   3169  N   ARG A 403     -14.841  18.915   2.855  1.00 97.26           N  \\nATOM   3170  CA  ARG A 403     -13.721  18.904   3.805  1.00 97.26           C  \\nATOM   3171  C   ARG A 403     -13.480  17.480   4.249  1.00 97.26           C  \\nATOM   3172  CB  ARG A 403     -14.018  19.781   5.022  1.00 97.26           C  \\nATOM   3173  O   ARG A 403     -14.407  16.822   4.703  1.00 97.26           O  \\nATOM   3174  CG  ARG A 403     -13.972  21.250   4.627  1.00 97.26           C  \\nATOM   3175  CD  ARG A 403     -14.235  22.142   5.829  1.00 97.26           C  \\nATOM   3176  NE  ARG A 403     -13.964  23.523   5.437  1.00 97.26           N  \\nATOM   3177  NH1 ARG A 403     -14.837  24.611   7.240  1.00 97.26           N  \\nATOM   3178  NH2 ARG A 403     -13.980  25.755   5.491  1.00 97.26           N  \\nATOM   3179  CZ  ARG A 403     -14.271  24.626   6.064  1.00 97.26           C  \\nATOM   3180  N   ILE A 404     -12.250  17.008   4.106  1.00 97.41           N  \\nATOM   3181  CA  ILE A 404     -11.933  15.626   4.440  1.00 97.41           C  \\nATOM   3182  C   ILE A 404     -10.504  15.487   4.934  1.00 97.41           C  \\nATOM   3183  CB  ILE A 404     -12.247  14.708   3.239  1.00 97.41           C  \\nATOM   3184  O   ILE A 404      -9.586  16.166   4.465  1.00 97.41           O  \\nATOM   3185  CG1 ILE A 404     -12.286  13.236   3.690  1.00 97.41           C  \\nATOM   3186  CG2 ILE A 404     -11.278  14.926   2.060  1.00 97.41           C  \\nATOM   3187  CD1 ILE A 404     -12.971  12.330   2.668  1.00 97.41           C  \\nATOM   3188  N   THR A 405     -10.319  14.548   5.851  1.00 98.13           N  \\nATOM   3189  CA  THR A 405      -9.004  14.127   6.307  1.00 98.13           C  \\nATOM   3190  C   THR A 405      -8.695  12.723   5.795  1.00 98.13           C  \\nATOM   3191  CB  THR A 405      -8.869  14.311   7.822  1.00 98.13           C  \\nATOM   3192  O   THR A 405      -9.552  11.838   5.757  1.00 98.13           O  \\nATOM   3193  CG2 THR A 405      -7.534  13.815   8.359  1.00 98.13           C  \\nATOM   3194  OG1 THR A 405      -8.946  15.690   8.085  1.00 98.13           O  \\nATOM   3195  N   VAL A 406      -7.450  12.526   5.371  1.00 98.51           N  \\nATOM   3196  CA  VAL A 406      -6.920  11.247   4.902  1.00 98.51           C  \\nATOM   3197  C   VAL A 406      -5.826  10.803   5.865  1.00 98.51           C  \\nATOM   3198  CB  VAL A 406      -6.395  11.356   3.459  1.00 98.51           C  \\nATOM   3199  O   VAL A 406      -4.773  11.442   5.959  1.00 98.51           O  \\nATOM   3200  CG1 VAL A 406      -5.929   9.990   2.944  1.00 98.51           C  \\nATOM   3201  CG2 VAL A 406      -7.447  11.900   2.483  1.00 98.51           C  \\nATOM   3202  N   GLY A 407      -6.071   9.704   6.570  1.00 97.72           N  \\nATOM   3203  CA  GLY A 407      -5.066   9.021   7.375  1.00 97.72           C  \\nATOM   3204  C   GLY A 407      -4.169   8.178   6.476  1.00 97.72           C  \\nATOM   3205  O   GLY A 407      -4.665   7.344   5.721  1.00 97.72           O  \\nATOM   3206  N   VAL A 408      -2.854   8.381   6.537  1.00 97.79           N  \\nATOM   3207  CA  VAL A 408      -1.888   7.671   5.691  1.00 97.79           C  \\nATOM   3208  C   VAL A 408      -0.822   6.994   6.545  1.00 97.79           C  \\nATOM   3209  CB  VAL A 408      -1.241   8.587   4.632  1.00 97.79           C  \\nATOM   3210  O   VAL A 408      -0.188   7.622   7.394  1.00 97.79           O  \\nATOM   3211  CG1 VAL A 408      -0.512   7.741   3.576  1.00 97.79           C  \\nATOM   3212  CG2 VAL A 408      -2.245   9.474   3.882  1.00 97.79           C  \\nATOM   3213  N   ASP A 409      -0.585   5.714   6.284  1.00 95.43           N  \\nATOM   3214  CA  ASP A 409       0.547   4.948   6.805  1.00 95.43           C  \\nATOM   3215  C   ASP A 409       1.335   4.315   5.640  1.00 95.43           C  \\nATOM   3216  CB  ASP A 409       0.046   3.919   7.844  1.00 95.43           C  \\nATOM   3217  O   ASP A 409       0.920   4.346   4.482  1.00 95.43           O  \\nATOM   3218  CG  ASP A 409       1.108   3.476   8.863  1.00 95.43           C  \\nATOM   3219  OD1 ASP A 409       2.321   3.682   8.613  1.00 95.43           O  \\nATOM   3220  OD2 ASP A 409       0.739   2.972   9.941  1.00 95.43           O  \\nATOM   3221  N   GLY A 410       2.493   3.736   5.934  1.00 93.71           N  \\nATOM   3222  CA  GLY A 410       3.334   3.016   4.993  1.00 93.71           C  \\nATOM   3223  C   GLY A 410       4.702   3.662   4.785  1.00 93.71           C  \\nATOM   3224  O   GLY A 410       4.882   4.880   4.794  1.00 93.71           O  \\nATOM   3225  N   SER A 411       5.705   2.807   4.600  1.00 93.45           N  \\nATOM   3226  CA  SER A 411       7.112   3.201   4.516  1.00 93.45           C  \\nATOM   3227  C   SER A 411       7.436   4.118   3.336  1.00 93.45           C  \\nATOM   3228  CB  SER A 411       7.984   1.944   4.439  1.00 93.45           C  \\nATOM   3229  O   SER A 411       8.307   4.970   3.476  1.00 93.45           O  \\nATOM   3230  OG  SER A 411       7.527   1.082   3.409  1.00 93.45           O  \\nATOM   3231  N   VAL A 412       6.754   3.991   2.193  1.00 96.83           N  \\nATOM   3232  CA  VAL A 412       6.999   4.862   1.032  1.00 96.83           C  \\nATOM   3233  C   VAL A 412       6.534   6.280   1.343  1.00 96.83           C  \\nATOM   3234  CB  VAL A 412       6.334   4.312  -0.243  1.00 96.83           C  \\nATOM   3235  O   VAL A 412       7.294   7.222   1.145  1.00 96.83           O  \\nATOM   3236  CG1 VAL A 412       6.449   5.272  -1.432  1.00 96.83           C  \\nATOM   3237  CG2 VAL A 412       6.963   2.976  -0.651  1.00 96.83           C  \\nATOM   3238  N   TYR A 413       5.335   6.442   1.904  1.00 97.55           N  \\nATOM   3239  CA  TYR A 413       4.828   7.761   2.284  1.00 97.55           C  \\nATOM   3240  C   TYR A 413       5.661   8.428   3.385  1.00 97.55           C  \\nATOM   3241  CB  TYR A 413       3.374   7.617   2.724  1.00 97.55           C  \\nATOM   3242  O   TYR A 413       5.941   9.623   3.301  1.00 97.55           O  \\nATOM   3243  CG  TYR A 413       2.723   8.918   3.123  1.00 97.55           C  \\nATOM   3244  CD1 TYR A 413       2.639   9.280   4.481  1.00 97.55           C  \\nATOM   3245  CD2 TYR A 413       2.170   9.746   2.129  1.00 97.55           C  \\nATOM   3246  CE1 TYR A 413       1.964  10.454   4.853  1.00 97.55           C  \\nATOM   3247  CE2 TYR A 413       1.496  10.923   2.498  1.00 97.55           C  \\nATOM   3248  OH  TYR A 413       0.665  12.364   4.220  1.00 97.55           O  \\nATOM   3249  CZ  TYR A 413       1.376  11.265   3.860  1.00 97.55           C  \\nATOM   3250  N   LYS A 414       6.064   7.655   4.399  1.00 95.52           N  \\nATOM   3251  CA  LYS A 414       6.765   8.170   5.584  1.00 95.52           C  \\nATOM   3252  C   LYS A 414       8.254   8.423   5.366  1.00 95.52           C  \\nATOM   3253  CB  LYS A 414       6.575   7.187   6.744  1.00 95.52           C  \\nATOM   3254  O   LYS A 414       8.808   9.358   5.932  1.00 95.52           O  \\nATOM   3255  CG  LYS A 414       5.117   7.124   7.211  1.00 95.52           C  \\nATOM   3256  CD  LYS A 414       4.999   6.190   8.415  1.00 95.52           C  \\nATOM   3257  CE  LYS A 414       3.686   6.452   9.140  1.00 95.52           C  \\nATOM   3258  NZ  LYS A 414       3.470   5.453  10.201  1.00 95.52           N  \\nATOM   3259  N   LEU A 415       8.925   7.561   4.598  1.00 95.41           N  \\nATOM   3260  CA  LEU A 415      10.392   7.518   4.546  1.00 95.41           C  \\nATOM   3261  C   LEU A 415      10.977   7.985   3.209  1.00 95.41           C  \\nATOM   3262  CB  LEU A 415      10.902   6.103   4.889  1.00 95.41           C  \\nATOM   3263  O   LEU A 415      12.178   8.243   3.141  1.00 95.41           O  \\nATOM   3264  CG  LEU A 415      10.332   5.469   6.173  1.00 95.41           C  \\nATOM   3265  CD1 LEU A 415      10.907   4.061   6.340  1.00 95.41           C  \\nATOM   3266  CD2 LEU A 415      10.676   6.279   7.423  1.00 95.41           C  \\nATOM   3267  N   HIS A 416      10.185   8.069   2.134  1.00 97.67           N  \\nATOM   3268  CA  HIS A 416      10.684   8.593   0.863  1.00 97.67           C  \\nATOM   3269  C   HIS A 416      10.718  10.131   0.896  1.00 97.67           C  \\nATOM   3270  CB  HIS A 416       9.844   8.070  -0.302  1.00 97.67           C  \\nATOM   3271  O   HIS A 416       9.685  10.749   1.166  1.00 97.67           O  \\nATOM   3272  CG  HIS A 416      10.497   8.301  -1.637  1.00 97.67           C  \\nATOM   3273  CD2 HIS A 416      11.195   7.367  -2.353  1.00 97.67           C  \\nATOM   3274  ND1 HIS A 416      10.537   9.476  -2.360  1.00 97.67           N  \\nATOM   3275  CE1 HIS A 416      11.237   9.248  -3.481  1.00 97.67           C  \\nATOM   3276  NE2 HIS A 416      11.662   7.980  -3.512  1.00 97.67           N  \\nATOM   3277  N   PRO A 417      11.852  10.780   0.567  1.00 97.21           N  \\nATOM   3278  CA  PRO A 417      12.072  12.207   0.840  1.00 97.21           C  \\nATOM   3279  C   PRO A 417      11.101  13.146   0.110  1.00 97.21           C  \\nATOM   3280  CB  PRO A 417      13.519  12.470   0.396  1.00 97.21           C  \\nATOM   3281  O   PRO A 417      10.757  14.207   0.617  1.00 97.21           O  \\nATOM   3282  CG  PRO A 417      13.776  11.387  -0.652  1.00 97.21           C  \\nATOM   3283  CD  PRO A 417      13.038  10.200  -0.049  1.00 97.21           C  \\nATOM   3284  N   SER A 418      10.667  12.760  -1.088  1.00 96.74           N  \\nATOM   3285  CA  SER A 418       9.920  13.611  -2.023  1.00 96.74           C  \\nATOM   3286  C   SER A 418       8.529  13.069  -2.378  1.00 96.74           C  \\nATOM   3287  CB  SER A 418      10.769  13.723  -3.292  1.00 96.74           C  \\nATOM   3288  O   SER A 418       7.746  13.759  -3.032  1.00 96.74           O  \\nATOM   3289  OG  SER A 418      10.969  12.401  -3.768  1.00 96.74           O  \\nATOM   3290  N   PHE A 419       8.195  11.835  -1.969  1.00 98.45           N  \\nATOM   3291  CA  PHE A 419       6.973  11.162  -2.431  1.00 98.45           C  \\nATOM   3292  C   PHE A 419       5.731  11.884  -1.910  1.00 98.45           C  \\nATOM   3293  CB  PHE A 419       6.971   9.689  -1.999  1.00 98.45           C  \\nATOM   3294  O   PHE A 419       4.843  12.224  -2.687  1.00 98.45           O  \\nATOM   3295  CG  PHE A 419       5.789   8.892  -2.515  1.00 98.45           C  \\nATOM   3296  CD1 PHE A 419       4.542   8.963  -1.862  1.00 98.45           C  \\nATOM   3297  CD2 PHE A 419       5.934   8.071  -3.650  1.00 98.45           C  \\nATOM   3298  CE1 PHE A 419       3.441   8.247  -2.360  1.00 98.45           C  \\nATOM   3299  CE2 PHE A 419       4.841   7.324  -4.122  1.00 98.45           C  \\nATOM   3300  CZ  PHE A 419       3.593   7.417  -3.483  1.00 98.45           C  \\nATOM   3301  N   LYS A 420       5.707  12.169  -0.602  1.00 97.84           N  \\nATOM   3302  CA  LYS A 420       4.611  12.854   0.096  1.00 97.84           C  \\nATOM   3303  C   LYS A 420       4.275  14.202  -0.544  1.00 97.84           C  \\nATOM   3304  CB  LYS A 420       5.014  12.974   1.576  1.00 97.84           C  \\nATOM   3305  O   LYS A 420       3.113  14.464  -0.836  1.00 97.84           O  \\nATOM   3306  CG  LYS A 420       3.972  13.642   2.491  1.00 97.84           C  \\nATOM   3307  CD  LYS A 420       4.410  13.453   3.956  1.00 97.84           C  \\nATOM   3308  CE  LYS A 420       3.440  14.045   4.988  1.00 97.84           C  \\nATOM   3309  NZ  LYS A 420       3.849  13.687   6.381  1.00 97.84           N  \\nATOM   3310  N   GLU A 421       5.288  15.017  -0.837  1.00 98.17           N  \\nATOM   3311  CA  GLU A 421       5.108  16.328  -1.472  1.00 98.17           C  \\nATOM   3312  C   GLU A 421       4.501  16.207  -2.879  1.00 98.17           C  \\nATOM   3313  CB  GLU A 421       6.461  17.053  -1.515  1.00 98.17           C  \\nATOM   3314  O   GLU A 421       3.492  16.852  -3.176  1.00 98.17           O  \\nATOM   3315  CG  GLU A 421       6.326  18.489  -2.046  1.00 98.17           C  \\nATOM   3316  CD  GLU A 421       7.673  19.208  -2.216  1.00 98.17           C  \\nATOM   3317  OE1 GLU A 421       7.643  20.326  -2.776  1.00 98.17           O  \\nATOM   3318  OE2 GLU A 421       8.712  18.637  -1.816  1.00 98.17           O  \\nATOM   3319  N   ARG A 422       5.074  15.343  -3.731  1.00 98.35           N  \\nATOM   3320  CA  ARG A 422       4.594  15.114  -5.107  1.00 98.35           C  \\nATOM   3321  C   ARG A 422       3.166  14.567  -5.117  1.00 98.35           C  \\nATOM   3322  CB  ARG A 422       5.549  14.153  -5.838  1.00 98.35           C  \\nATOM   3323  O   ARG A 422       2.323  15.048  -5.876  1.00 98.35           O  \\nATOM   3324  CG  ARG A 422       6.938  14.762  -6.102  1.00 98.35           C  \\nATOM   3325  CD  ARG A 422       7.885  13.697  -6.675  1.00 98.35           C  \\nATOM   3326  NE  ARG A 422       9.277  14.183  -6.792  1.00 98.35           N  \\nATOM   3327  NH1 ARG A 422      10.319  12.124  -6.780  1.00 98.35           N  \\nATOM   3328  NH2 ARG A 422      11.558  13.921  -6.686  1.00 98.35           N  \\nATOM   3329  CZ  ARG A 422      10.361  13.419  -6.768  1.00 98.35           C  \\nATOM   3330  N   PHE A 423       2.888  13.609  -4.234  1.00 98.65           N  \\nATOM   3331  CA  PHE A 423       1.570  13.018  -4.036  1.00 98.65           C  \\nATOM   3332  C   PHE A 423       0.542  14.083  -3.630  1.00 98.65           C  \\nATOM   3333  CB  PHE A 423       1.695  11.889  -3.005  1.00 98.65           C  \\nATOM   3334  O   PHE A 423      -0.445  14.268  -4.338  1.00 98.65           O  \\nATOM   3335  CG  PHE A 423       0.376  11.341  -2.507  1.00 98.65           C  \\nATOM   3336  CD1 PHE A 423       0.013  11.522  -1.161  1.00 98.65           C  \\nATOM   3337  CD2 PHE A 423      -0.484  10.649  -3.379  1.00 98.65           C  \\nATOM   3338  CE1 PHE A 423      -1.208  11.017  -0.684  1.00 98.65           C  \\nATOM   3339  CE2 PHE A 423      -1.702  10.137  -2.899  1.00 98.65           C  \\nATOM   3340  CZ  PHE A 423      -2.057  10.315  -1.553  1.00 98.65           C  \\nATOM   3341  N   HIS A 424       0.797  14.858  -2.568  1.00 98.52           N  \\nATOM   3342  CA  HIS A 424      -0.119  15.910  -2.103  1.00 98.52           C  \\nATOM   3343  C   HIS A 424      -0.375  16.977  -3.166  1.00 98.52           C  \\nATOM   3344  CB  HIS A 424       0.456  16.605  -0.860  1.00 98.52           C  \\nATOM   3345  O   HIS A 424      -1.518  17.389  -3.368  1.00 98.52           O  \\nATOM   3346  CG  HIS A 424       0.505  15.794   0.405  1.00 98.52           C  \\nATOM   3347  CD2 HIS A 424       0.042  14.524   0.588  1.00 98.52           C  \\nATOM   3348  ND1 HIS A 424       0.957  16.295   1.626  1.00 98.52           N  \\nATOM   3349  CE1 HIS A 424       0.778  15.303   2.510  1.00 98.52           C  \\nATOM   3350  NE2 HIS A 424       0.245  14.225   1.915  1.00 98.52           N  \\nATOM   3351  N   ALA A 425       0.675  17.437  -3.851  1.00 98.29           N  \\nATOM   3352  CA  ALA A 425       0.545  18.443  -4.899  1.00 98.29           C  \\nATOM   3353  C   ALA A 425      -0.334  17.947  -6.055  1.00 98.29           C  \\nATOM   3354  CB  ALA A 425       1.947  18.827  -5.383  1.00 98.29           C  \\nATOM   3355  O   ALA A 425      -1.141  18.712  -6.580  1.00 98.29           O  \\nATOM   3356  N   SER A 426      -0.192  16.677  -6.439  1.00 98.47           N  \\nATOM   3357  CA  SER A 426      -0.983  16.079  -7.511  1.00 98.47           C  \\nATOM   3358  C   SER A 426      -2.439  15.839  -7.109  1.00 98.47           C  \\nATOM   3359  CB  SER A 426      -0.292  14.808  -7.995  1.00 98.47           C  \\nATOM   3360  O   SER A 426      -3.331  16.214  -7.866  1.00 98.47           O  \\nATOM   3361  OG  SER A 426      -0.895  14.375  -9.190  1.00 98.47           O  \\nATOM   3362  N   VAL A 427      -2.700  15.342  -5.891  1.00 98.58           N  \\nATOM   3363  CA  VAL A 427      -4.074  15.172  -5.379  1.00 98.58           C  \\nATOM   3364  C   VAL A 427      -4.827  16.502  -5.422  1.00 98.58           C  \\nATOM   3365  CB  VAL A 427      -4.090  14.592  -3.951  1.00 98.58           C  \\nATOM   3366  O   VAL A 427      -5.896  16.573  -6.017  1.00 98.58           O  \\nATOM   3367  CG1 VAL A 427      -5.510  14.535  -3.378  1.00 98.58           C  \\nATOM   3368  CG2 VAL A 427      -3.548  13.161  -3.906  1.00 98.58           C  \\nATOM   3369  N   ARG A 428      -4.232  17.587  -4.902  1.00 97.99           N  \\nATOM   3370  CA  ARG A 428      -4.873  18.916  -4.877  1.00 97.99           C  \\nATOM   3371  C   ARG A 428      -5.260  19.436  -6.265  1.00 97.99           C  \\nATOM   3372  CB  ARG A 428      -3.957  19.935  -4.188  1.00 97.99           C  \\nATOM   3373  O   ARG A 428      -6.267  20.124  -6.386  1.00 97.99           O  \\nATOM   3374  CG  ARG A 428      -3.847  19.702  -2.676  1.00 97.99           C  \\nATOM   3375  CD  ARG A 428      -2.901  20.743  -2.067  1.00 97.99           C  \\nATOM   3376  NE  ARG A 428      -2.589  20.428  -0.660  1.00 97.99           N  \\nATOM   3377  NH1 ARG A 428      -0.290  20.333  -0.817  1.00 97.99           N  \\nATOM   3378  NH2 ARG A 428      -1.291  19.869   1.120  1.00 97.99           N  \\nATOM   3379  CZ  ARG A 428      -1.395  20.218  -0.131  1.00 97.99           C  \\nATOM   3380  N   ARG A 429      -4.484  19.120  -7.309  1.00 97.99           N  \\nATOM   3381  CA  ARG A 429      -4.830  19.494  -8.695  1.00 97.99           C  \\nATOM   3382  C   ARG A 429      -6.012  18.688  -9.236  1.00 97.99           C  \\nATOM   3383  CB  ARG A 429      -3.623  19.324  -9.628  1.00 97.99           C  \\nATOM   3384  O   ARG A 429      -6.802  19.220 -10.007  1.00 97.99           O  \\nATOM   3385  CG  ARG A 429      -2.515  20.355  -9.371  1.00 97.99           C  \\nATOM   3386  CD  ARG A 429      -1.435  20.292 -10.460  1.00 97.99           C  \\nATOM   3387  NE  ARG A 429      -0.795  18.963 -10.559  1.00 97.99           N  \\nATOM   3388  NH1 ARG A 429       0.907  19.262  -9.046  1.00 97.99           N  \\nATOM   3389  NH2 ARG A 429       0.760  17.341 -10.170  1.00 97.99           N  \\nATOM   3390  CZ  ARG A 429       0.284  18.532  -9.929  1.00 97.99           C  \\nATOM   3391  N   LEU A 430      -6.130  17.423  -8.837  1.00 98.58           N  \\nATOM   3392  CA  LEU A 430      -7.182  16.509  -9.292  1.00 98.58           C  \\nATOM   3393  C   LEU A 430      -8.491  16.639  -8.492  1.00 98.58           C  \\nATOM   3394  CB  LEU A 430      -6.631  15.073  -9.252  1.00 98.58           C  \\nATOM   3395  O   LEU A 430      -9.535  16.182  -8.957  1.00 98.58           O  \\nATOM   3396  CG  LEU A 430      -5.439  14.806 -10.190  1.00 98.58           C  \\nATOM   3397  CD1 LEU A 430      -4.883  13.409  -9.921  1.00 98.58           C  \\nATOM   3398  CD2 LEU A 430      -5.830  14.895 -11.668  1.00 98.58           C  \\nATOM   3399  N   THR A 431      -8.458  17.288  -7.325  1.00 98.02           N  \\nATOM   3400  CA  THR A 431      -9.617  17.496  -6.438  1.00 98.02           C  \\nATOM   3401  C   THR A 431      -9.827  18.985  -6.095  1.00 98.02           C  \\nATOM   3402  CB  THR A 431      -9.473  16.649  -5.161  1.00 98.02           C  \\nATOM   3403  O   THR A 431      -9.805  19.354  -4.918  1.00 98.02           O  \\nATOM   3404  CG2 THR A 431      -9.295  15.157  -5.430  1.00 98.02           C  \\nATOM   3405  OG1 THR A 431      -8.355  17.099  -4.429  1.00 98.02           O  \\nATOM   3406  N   PRO A 432     -10.027  19.886  -7.079  1.00 96.88           N  \\nATOM   3407  CA  PRO A 432     -10.092  21.336  -6.839  1.00 96.88           C  \\nATOM   3408  C   PRO A 432     -11.274  21.777  -5.957  1.00 96.88           C  \\nATOM   3409  CB  PRO A 432     -10.185  21.961  -8.235  1.00 96.88           C  \\nATOM   3410  O   PRO A 432     -11.250  22.870  -5.398  1.00 96.88           O  \\nATOM   3411  CG  PRO A 432     -10.848  20.868  -9.073  1.00 96.88           C  \\nATOM   3412  CD  PRO A 432     -10.242  19.595  -8.489  1.00 96.88           C  \\nATOM   3413  N   SER A 433     -12.298  20.933  -5.828  1.00 96.98           N  \\nATOM   3414  CA  SER A 433     -13.488  21.160  -4.999  1.00 96.98           C  \\nATOM   3415  C   SER A 433     -13.397  20.494  -3.620  1.00 96.98           C  \\nATOM   3416  CB  SER A 433     -14.734  20.685  -5.753  1.00 96.98           C  \\nATOM   3417  O   SER A 433     -14.423  20.276  -2.983  1.00 96.98           O  \\nATOM   3418  OG  SER A 433     -14.870  21.380  -6.980  1.00 96.98           O  \\nATOM   3419  N   CYS A 434     -12.200  20.110  -3.167  1.00 97.41           N  \\nATOM   3420  CA  CYS A 434     -12.003  19.455  -1.874  1.00 97.41           C  \\nATOM   3421  C   CYS A 434     -10.891  20.134  -1.065  1.00 97.41           C  \\nATOM   3422  CB  CYS A 434     -11.706  17.962  -2.076  1.00 97.41           C  \\nATOM   3423  O   CYS A 434      -9.795  20.383  -1.569  1.00 97.41           O  \\nATOM   3424  SG  CYS A 434     -13.060  17.145  -2.970  1.00 97.41           S  \\nATOM   3425  N   GLU A 435     -11.153  20.377   0.216  1.00 97.22           N  \\nATOM   3426  CA  GLU A 435     -10.158  20.795   1.202  1.00 97.22           C  \\nATOM   3427  C   GLU A 435      -9.650  19.543   1.931  1.00 97.22           C  \\nATOM   3428  CB  GLU A 435     -10.769  21.809   2.181  1.00 97.22           C  \\nATOM   3429  O   GLU A 435     -10.371  18.948   2.732  1.00 97.22           O  \\nATOM   3430  CG  GLU A 435     -11.081  23.181   1.555  1.00 97.22           C  \\nATOM   3431  CD  GLU A 435     -11.714  24.185   2.545  1.00 97.22           C  \\nATOM   3432  OE1 GLU A 435     -12.108  25.291   2.115  1.00 97.22           O  \\nATOM   3433  OE2 GLU A 435     -11.842  23.891   3.756  1.00 97.22           O  \\nATOM   3434  N   ILE A 436      -8.420  19.123   1.616  1.00 98.10           N  \\nATOM   3435  CA  ILE A 436      -7.862  17.846   2.082  1.00 98.10           C  \\nATOM   3436  C   ILE A 436      -6.751  18.077   3.105  1.00 98.10           C  \\nATOM   3437  CB  ILE A 436      -7.371  16.966   0.913  1.00 98.10           C  \\nATOM   3438  O   ILE A 436      -5.720  18.687   2.791  1.00 98.10           O  \\nATOM   3439  CG1 ILE A 436      -8.491  16.740  -0.127  1.00 98.10           C  \\nATOM   3440  CG2 ILE A 436      -6.879  15.607   1.458  1.00 98.10           C  \\nATOM   3441  CD1 ILE A 436      -7.964  16.184  -1.448  1.00 98.10           C  \\nATOM   3442  N   THR A 437      -6.931  17.498   4.288  1.00 98.17           N  \\nATOM   3443  CA  THR A 437      -5.894  17.369   5.317  1.00 98.17           C  \\nATOM   3444  C   THR A 437      -5.314  15.957   5.280  1.00 98.17           C  \\nATOM   3445  CB  THR A 437      -6.462  17.704   6.700  1.00 98.17           C  \\nATOM   3446  O   THR A 437      -6.042  14.978   5.155  1.00 98.17           O  \\nATOM   3447  CG2 THR A 437      -5.429  17.603   7.823  1.00 98.17           C  \\nATOM   3448  OG1 THR A 437      -6.920  19.035   6.703  1.00 98.17           O  \\nATOM   3449  N   PHE A 438      -3.994  15.826   5.395  1.00 98.15           N  \\nATOM   3450  CA  PHE A 438      -3.334  14.523   5.492  1.00 98.15           C  \\nATOM   3451  C   PHE A 438      -2.746  14.347   6.886  1.00 98.15           C  \\nATOM   3452  CB  PHE A 438      -2.246  14.387   4.426  1.00 98.15           C  \\nATOM   3453  O   PHE A 438      -1.930  15.169   7.306  1.00 98.15           O  \\nATOM   3454  CG  PHE A 438      -2.765  14.311   3.007  1.00 98.15           C  \\nATOM   3455  CD1 PHE A 438      -3.146  13.068   2.472  1.00 98.15           C  \\nATOM   3456  CD2 PHE A 438      -2.851  15.471   2.214  1.00 98.15           C  \\nATOM   3457  CE1 PHE A 438      -3.602  12.983   1.148  1.00 98.15           C  \\nATOM   3458  CE2 PHE A 438      -3.306  15.385   0.886  1.00 98.15           C  \\nATOM   3459  CZ  PHE A 438      -3.677  14.139   0.352  1.00 98.15           C  \\nATOM   3460  N   ILE A 439      -3.106  13.256   7.557  1.00 95.95           N  \\nATOM   3461  CA  ILE A 439      -2.537  12.869   8.850  1.00 95.95           C  \\nATOM   3462  C   ILE A 439      -1.671  11.637   8.637  1.00 95.95           C  \\nATOM   3463  CB  ILE A 439      -3.628  12.671   9.924  1.00 95.95           C  \\nATOM   3464  O   ILE A 439      -2.076  10.665   8.004  1.00 95.95           O  \\nATOM   3465  CG1 ILE A 439      -4.355  14.016  10.145  1.00 95.95           C  \\nATOM   3466  CG2 ILE A 439      -3.009  12.162  11.241  1.00 95.95           C  \\nATOM   3467  CD1 ILE A 439      -5.454  13.967  11.209  1.00 95.95           C  \\nATOM   3468  N   GLU A 440      -0.445  11.694   9.137  1.00 95.20           N  \\nATOM   3469  CA  GLU A 440       0.439  10.539   9.153  1.00 95.20           C  \\nATOM   3470  C   GLU A 440       0.131   9.697  10.389  1.00 95.20           C  \\nATOM   3471  CB  GLU A 440       1.880  11.037   9.109  1.00 95.20           C  \\nATOM   3472  O   GLU A 440       0.173  10.201  11.505  1.00 95.20           O  \\nATOM   3473  CG  GLU A 440       2.869   9.885   8.947  1.00 95.20           C  \\nATOM   3474  CD  GLU A 440       4.284  10.413   8.696  1.00 95.20           C  \\nATOM   3475  OE1 GLU A 440       5.218   9.811   9.268  1.00 95.20           O  \\nATOM   3476  OE2 GLU A 440       4.415  11.358   7.865  1.00 95.20           O  \\nATOM   3477  N   SER A 441      -0.213   8.428  10.194  1.00 90.21           N  \\nATOM   3478  CA  SER A 441      -0.672   7.577  11.290  1.00 90.21           C  \\nATOM   3479  C   SER A 441       0.495   7.055  12.127  1.00 90.21           C  \\nATOM   3480  CB  SER A 441      -1.475   6.420  10.707  1.00 90.21           C  \\nATOM   3481  O   SER A 441       1.377   6.383  11.594  1.00 90.21           O  \\nATOM   3482  OG  SER A 441      -2.319   5.886  11.696  1.00 90.21           O  \\nATOM   3483  N   GLU A 442       0.517   7.298  13.436  1.00 83.01           N  \\nATOM   3484  CA  GLU A 442       1.490   6.680  14.345  1.00 83.01           C  \\nATOM   3485  C   GLU A 442       0.958   5.336  14.864  1.00 83.01           C  \\nATOM   3486  CB  GLU A 442       1.862   7.624  15.495  1.00 83.01           C  \\nATOM   3487  O   GLU A 442      -0.054   5.276  15.557  1.00 83.01           O  \\nATOM   3488  CG  GLU A 442       2.634   8.860  15.001  1.00 83.01           C  \\nATOM   3489  CD  GLU A 442       3.233   9.702  16.142  1.00 83.01           C  \\nATOM   3490  OE1 GLU A 442       3.965  10.665  15.817  1.00 83.01           O  \\nATOM   3491  OE2 GLU A 442       3.025   9.349  17.326  1.00 83.01           O  \\nATOM   3492  N   GLU A 443       1.633   4.235  14.510  1.00 77.64           N  \\nATOM   3493  CA  GLU A 443       1.215   2.866  14.862  1.00 77.64           C  \\nATOM   3494  C   GLU A 443      -0.220   2.497  14.416  1.00 77.64           C  \\nATOM   3495  CB  GLU A 443       1.459   2.564  16.358  1.00 77.64           C  \\nATOM   3496  O   GLU A 443      -0.873   1.650  15.036  1.00 77.64           O  \\nATOM   3497  CG  GLU A 443       2.886   2.866  16.842  1.00 77.64           C  \\nATOM   3498  CD  GLU A 443       3.132   2.449  18.306  1.00 77.64           C  \\nATOM   3499  OE1 GLU A 443       4.315   2.248  18.652  1.00 77.64           O  \\nATOM   3500  OE2 GLU A 443       2.170   2.219  19.077  1.00 77.64           O  \\nATOM   3501  N   GLY A 444      -0.684   3.095  13.312  1.00 80.51           N  \\nATOM   3502  CA  GLY A 444      -2.086   3.126  12.892  1.00 80.51           C  \\nATOM   3503  C   GLY A 444      -2.797   1.784  12.849  1.00 80.51           C  \\nATOM   3504  O   GLY A 444      -3.886   1.643  13.401  1.00 80.51           O  \\nATOM   3505  N   SER A 445      -2.167   0.773  12.251  1.00 84.98           N  \\nATOM   3506  CA  SER A 445      -2.765  -0.558  12.108  1.00 84.98           C  \\nATOM   3507  C   SER A 445      -3.056  -1.238  13.450  1.00 84.98           C  \\nATOM   3508  CB  SER A 445      -1.884  -1.455  11.235  1.00 84.98           C  \\nATOM   3509  O   SER A 445      -4.115  -1.835  13.626  1.00 84.98           O  \\nATOM   3510  OG  SER A 445      -0.534  -1.336  11.609  1.00 84.98           O  \\nATOM   3511  N   GLY A 446      -2.156  -1.139  14.428  1.00 87.43           N  \\nATOM   3512  CA  GLY A 446      -2.364  -1.760  15.735  1.00 87.43           C  \\nATOM   3513  C   GLY A 446      -3.289  -0.949  16.641  1.00 87.43           C  \\nATOM   3514  O   GLY A 446      -4.148  -1.522  17.317  1.00 87.43           O  \\nATOM   3515  N   ARG A 447      -3.155   0.382  16.641  1.00 89.93           N  \\nATOM   3516  CA  ARG A 447      -4.031   1.277  17.411  1.00 89.93           C  \\nATOM   3517  C   ARG A 447      -5.467   1.242  16.892  1.00 89.93           C  \\nATOM   3518  CB  ARG A 447      -3.430   2.689  17.374  1.00 89.93           C  \\nATOM   3519  O   ARG A 447      -6.401   1.127  17.682  1.00 89.93           O  \\nATOM   3520  CG  ARG A 447      -4.282   3.713  18.135  1.00 89.93           C  \\nATOM   3521  CD  ARG A 447      -3.481   5.007  18.298  1.00 89.93           C  \\nATOM   3522  NE  ARG A 447      -4.262   6.100  18.911  1.00 89.93           N  \\nATOM   3523  NH1 ARG A 447      -2.985   7.815  18.056  1.00 89.93           N  \\nATOM   3524  NH2 ARG A 447      -4.706   8.300  19.337  1.00 89.93           N  \\nATOM   3525  CZ  ARG A 447      -3.985   7.387  18.769  1.00 89.93           C  \\nATOM   3526  N   GLY A 448      -5.636   1.270  15.574  1.00 91.59           N  \\nATOM   3527  CA  GLY A 448      -6.929   1.206  14.907  1.00 91.59           C  \\nATOM   3528  C   GLY A 448      -7.703  -0.069  15.209  1.00 91.59           C  \\nATOM   3529  O   GLY A 448      -8.854   0.016  15.622  1.00 91.59           O  \\nATOM   3530  N   ALA A 449      -7.074  -1.244  15.090  1.00 92.27           N  \\nATOM   3531  CA  ALA A 449      -7.737  -2.505  15.432  1.00 92.27           C  \\nATOM   3532  C   ALA A 449      -8.197  -2.554  16.892  1.00 92.27           C  \\nATOM   3533  CB  ALA A 449      -6.811  -3.680  15.126  1.00 92.27           C  \\nATOM   3534  O   ALA A 449      -9.303  -3.009  17.163  1.00 92.27           O  \\nATOM   3535  N   ALA A 450      -7.390  -2.049  17.829  1.00 91.57           N  \\nATOM   3536  CA  ALA A 450      -7.799  -1.970  19.228  1.00 91.57           C  \\nATOM   3537  C   ALA A 450      -9.005  -1.038  19.435  1.00 91.57           C  \\nATOM   3538  CB  ALA A 450      -6.604  -1.514  20.058  1.00 91.57           C  \\nATOM   3539  O   ALA A 450      -9.919  -1.381  20.180  1.00 91.57           O  \\nATOM   3540  N   LEU A 451      -9.039   0.112  18.757  1.00 91.10           N  \\nATOM   3541  CA  LEU A 451     -10.175   1.036  18.810  1.00 91.10           C  \\nATOM   3542  C   LEU A 451     -11.443   0.423  18.197  1.00 91.10           C  \\nATOM   3543  CB  LEU A 451      -9.795   2.344  18.098  1.00 91.10           C  \\nATOM   3544  O   LEU A 451     -12.519   0.559  18.774  1.00 91.10           O  \\nATOM   3545  CG  LEU A 451      -8.789   3.226  18.859  1.00 91.10           C  \\nATOM   3546  CD1 LEU A 451      -8.308   4.347  17.937  1.00 91.10           C  \\nATOM   3547  CD2 LEU A 451      -9.402   3.857  20.111  1.00 91.10           C  \\nATOM   3548  N   VAL A 452     -11.328  -0.303  17.080  1.00 91.67           N  \\nATOM   3549  CA  VAL A 452     -12.460  -1.043  16.494  1.00 91.67           C  \\nATOM   3550  C   VAL A 452     -12.971  -2.106  17.465  1.00 91.67           C  \\nATOM   3551  CB  VAL A 452     -12.100  -1.669  15.133  1.00 91.67           C  \\nATOM   3552  O   VAL A 452     -14.178  -2.190  17.687  1.00 91.67           O  \\nATOM   3553  CG1 VAL A 452     -13.252  -2.521  14.583  1.00 91.67           C  \\nATOM   3554  CG2 VAL A 452     -11.826  -0.575  14.095  1.00 91.67           C  \\nATOM   3555  N   SER A 453     -12.075  -2.862  18.105  1.00 91.63           N  \\nATOM   3556  CA  SER A 453     -12.443  -3.814  19.159  1.00 91.63           C  \\nATOM   3557  C   SER A 453     -13.178  -3.136  20.311  1.00 91.63           C  \\nATOM   3558  CB  SER A 453     -11.198  -4.505  19.715  1.00 91.63           C  \\nATOM   3559  O   SER A 453     -14.174  -3.661  20.800  1.00 91.63           O  \\nATOM   3560  OG  SER A 453     -10.627  -5.301  18.704  1.00 91.63           O  \\nATOM   3561  N   ALA A 454     -12.734  -1.949  20.722  1.00 90.17           N  \\nATOM   3562  CA  ALA A 454     -13.364  -1.199  21.798  1.00 90.17           C  \\nATOM   3563  C   ALA A 454     -14.799  -0.767  21.441  1.00 90.17           C  \\nATOM   3564  CB  ALA A 454     -12.437  -0.035  22.159  1.00 90.17           C  \\nATOM   3565  O   ALA A 454     -15.720  -0.944  22.243  1.00 90.17           O  \\nATOM   3566  N   VAL A 455     -15.013  -0.299  20.207  1.00 88.71           N  \\nATOM   3567  CA  VAL A 455     -16.347   0.018  19.668  1.00 88.71           C  \\nATOM   3568  C   VAL A 455     -17.226  -1.237  19.582  1.00 88.71           C  \\nATOM   3569  CB  VAL A 455     -16.220   0.703  18.291  1.00 88.71           C  \\nATOM   3570  O   VAL A 455     -18.390  -1.200  19.989  1.00 88.71           O  \\nATOM   3571  CG1 VAL A 455     -17.576   0.916  17.602  1.00 88.71           C  \\nATOM   3572  CG2 VAL A 455     -15.566   2.084  18.420  1.00 88.71           C  \\nATOM   3573  N   ALA A 456     -16.682  -2.357  19.096  1.00 87.79           N  \\nATOM   3574  CA  ALA A 456     -17.400  -3.628  18.984  1.00 87.79           C  \\nATOM   3575  C   ALA A 456     -17.861  -4.143  20.358  1.00 87.79           C  \\nATOM   3576  CB  ALA A 456     -16.499  -4.640  18.266  1.00 87.79           C  \\nATOM   3577  O   ALA A 456     -19.041  -4.449  20.546  1.00 87.79           O  \\nATOM   3578  N   CYS A 457     -16.964  -4.145  21.350  1.00 87.20           N  \\nATOM   3579  CA  CYS A 457     -17.287  -4.522  22.725  1.00 87.20           C  \\nATOM   3580  C   CYS A 457     -18.365  -3.612  23.330  1.00 87.20           C  \\nATOM   3581  CB  CYS A 457     -16.013  -4.478  23.581  1.00 87.20           C  \\nATOM   3582  O   CYS A 457     -19.307  -4.106  23.949  1.00 87.20           O  \\nATOM   3583  SG  CYS A 457     -14.884  -5.830  23.141  1.00 87.20           S  \\nATOM   3584  N   LYS A 458     -18.271  -2.291  23.127  1.00 84.51           N  \\nATOM   3585  CA  LYS A 458     -19.266  -1.331  23.627  1.00 84.51           C  \\nATOM   3586  C   LYS A 458     -20.657  -1.621  23.053  1.00 84.51           C  \\nATOM   3587  CB  LYS A 458     -18.791   0.094  23.299  1.00 84.51           C  \\nATOM   3588  O   LYS A 458     -21.623  -1.679  23.811  1.00 84.51           O  \\nATOM   3589  CG  LYS A 458     -19.611   1.200  23.985  1.00 84.51           C  \\nATOM   3590  CD  LYS A 458     -19.252   2.560  23.357  1.00 84.51           C  \\nATOM   3591  CE  LYS A 458     -19.936   3.779  23.993  1.00 84.51           C  \\nATOM   3592  NZ  LYS A 458     -19.628   5.015  23.221  1.00 84.51           N  \\nATOM   3593  N   LYS A 459     -20.764  -1.859  21.740  1.00 82.08           N  \\nATOM   3594  CA  LYS A 459     -22.039  -2.206  21.087  1.00 82.08           C  \\nATOM   3595  C   LYS A 459     -22.616  -3.525  21.591  1.00 82.08           C  \\nATOM   3596  CB  LYS A 459     -21.868  -2.276  19.567  1.00 82.08           C  \\nATOM   3597  O   LYS A 459     -23.809  -3.584  21.877  1.00 82.08           O  \\nATOM   3598  CG  LYS A 459     -21.756  -0.883  18.942  1.00 82.08           C  \\nATOM   3599  CD  LYS A 459     -21.750  -1.010  17.418  1.00 82.08           C  \\nATOM   3600  CE  LYS A 459     -21.624   0.379  16.798  1.00 82.08           C  \\nATOM   3601  NZ  LYS A 459     -21.627   0.312  15.320  1.00 82.08           N  \\nATOM   3602  N   ALA A 460     -21.784  -4.555  21.745  1.00 82.22           N  \\nATOM   3603  CA  ALA A 460     -22.218  -5.837  22.295  1.00 82.22           C  \\nATOM   3604  C   ALA A 460     -22.782  -5.684  23.720  1.00 82.22           C  \\nATOM   3605  CB  ALA A 460     -21.036  -6.811  22.245  1.00 82.22           C  \\nATOM   3606  O   ALA A 460     -23.827  -6.250  24.036  1.00 82.22           O  \\nATOM   3607  N   CYS A 461     -22.149  -4.851  24.555  1.00 79.15           N  \\nATOM   3608  CA  CYS A 461     -22.652  -4.526  25.891  1.00 79.15           C  \\nATOM   3609  C   CYS A 461     -23.994  -3.777  25.867  1.00 79.15           C  \\nATOM   3610  CB  CYS A 461     -21.598  -3.700  26.640  1.00 79.15           C  \\nATOM   3611  O   CYS A 461     -24.814  -4.020  26.745  1.00 79.15           O  \\nATOM   3612  SG  CYS A 461     -20.197  -4.751  27.118  1.00 79.15           S  \\nATOM   3613  N   MET A 462     -24.232  -2.889  24.893  1.00 75.71           N  \\nATOM   3614  CA  MET A 462     -25.513  -2.175  24.769  1.00 75.71           C  \\nATOM   3615  C   MET A 462     -26.651  -3.072  24.271  1.00 75.71           C  \\nATOM   3616  CB  MET A 462     -25.396  -0.979  23.817  1.00 75.71           C  \\nATOM   3617  O   MET A 462     -27.776  -2.903  24.712  1.00 75.71           O  \\nATOM   3618  CG  MET A 462     -24.501   0.146  24.332  1.00 75.71           C  \\nATOM   3619  SD  MET A 462     -24.649   1.631  23.303  1.00 75.71           S  \\nATOM   3620  CE  MET A 462     -23.136   2.505  23.741  1.00 75.71           C  \\nATOM   3621  N   LEU A 463     -26.373  -4.009  23.358  1.00 73.26           N  \\nATOM   3622  CA  LEU A 463     -27.381  -4.937  22.823  1.00 73.26           C  \\nATOM   3623  C   LEU A 463     -27.736  -6.072  23.796  1.00 73.26           C  \\nATOM   3624  CB  LEU A 463     -26.863  -5.528  21.499  1.00 73.26           C  \\nATOM   3625  O   LEU A 463     -28.789  -6.689  23.659  1.00 73.26           O  \\nATOM   3626  CG  LEU A 463     -26.836  -4.539  20.322  1.00 73.26           C  \\nATOM   3627  CD1 LEU A 463     -26.060  -5.161  19.159  1.00 73.26           C  \\nATOM   3628  CD2 LEU A 463     -28.243  -4.196  19.826  1.00 73.26           C  \\nATOM   3629  N   GLY A 464     -26.842  -6.382  24.738  1.00 62.21           N  \\nATOM   3630  CA  GLY A 464     -27.078  -7.371  25.791  1.00 62.21           C  \\nATOM   3631  C   GLY A 464     -27.823  -6.834  27.021  1.00 62.21           C  \\nATOM   3632  O   GLY A 464     -28.141  -7.631  27.906  1.00 62.21           O  \\nATOM   3633  N   GLN A 465     -28.059  -5.519  27.098  1.00 42.57           N  \\nATOM   3634  CA  GLN A 465     -28.887  -4.853  28.115  1.00 42.57           C  \\nATOM   3635  C   GLN A 465     -30.327  -4.736  27.624  1.00 42.57           C  \\nATOM   3636  CB  GLN A 465     -28.321  -3.456  28.420  1.00 42.57           C  \\nATOM   3637  O   GLN A 465     -31.233  -4.931  28.469  1.00 42.57           O  \\nATOM   3638  CG  GLN A 465     -27.037  -3.520  29.252  1.00 42.57           C  \\nATOM   3639  CD  GLN A 465     -26.400  -2.153  29.511  1.00 42.57           C  \\nATOM   3640  NE2 GLN A 465     -25.247  -2.123  30.145  1.00 42.57           N  \\nATOM   3641  OE1 GLN A 465     -26.898  -1.082  29.204  1.00 42.57           O  \\nATOM   3642  OXT GLN A 465     -30.476  -4.421  26.425  1.00 42.57           O  \\nEND   \"],\"format\":\"pdb\",\"keepH\":false,\"options\":{\"keepH\":false}},{\"method\":\"setStyle\",\"style\":{\"cartoon\":{\"style\":\"rectangle\",\"ribbon\":false,\"arrows\":true,\"tubes\":false,\"thickness\":0.4,\"opacity\":1,\"colorfunc\":\"function(atom) {\\n    const residue_colors = [ 'gray', '#023FA5', '#5D6CAE', '#5D6CAE', '#8C94BF', '#5D6CAE', '#B3B7CF', '#5D6CAE', '#5D6CAE', '#5D6CAE', '#5D6CAE', '#8C94BF', '#5D6CAE', '#5D6CAE', '#8C94BF', '#E2E2E2', '#5D6CAE', '#5D6CAE', '#8C94BF', '#AB5468', '#5D6CAE', '#5D6CAE', '#8E063B', '#5D6CAE', '#DDD0D2', '#023FA5', '#5D6CAE', '#023FA5', '#8C94BF', '#E2E2E2', '#5D6CAE', '#5D6CAE', '#DDD0D2', '#DDD0D2', '#5D6CAE', '#D2D3DC', '#D2B0B6', '#B3B7CF', '#5D6CAE', '#D2B0B6', '#AB5468', '#5D6CAE', '#B3B7CF', '#8E063B', '#8E063B', '#8C94BF', '#023FA5', '#5D6CAE', '#8C94BF', '#E2E2E2', '#5D6CAE', '#5D6CAE', '#D2B0B6', '#E2E2E2', '#C18692', '#AB5468', '#8E063B', '#8E063B', '#8E063B', '#C18692', '#C18692', '#8E063B', '#B3B7CF', '#B3B7CF', '#D2D3DC', '#8E063B', '#5D6CAE', '#AB5468', '#5D6CAE', '#8E063B', '#8C94BF', '#8E063B', '#DDD0D2', '#8E063B', '#8E063B', '#D2B0B6', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#D2B0B6', '#8E063B', '#8E063B', '#AB5468', '#AB5468', '#D2D3DC', '#C18692', '#8C94BF', '#DDD0D2', '#B3B7CF', '#5D6CAE', '#5D6CAE', '#023FA5', '#023FA5', '#5D6CAE', '#5D6CAE', '#DDD0D2', '#5D6CAE', '#D2D3DC', '#023FA5', '#B3B7CF', '#5D6CAE', '#8C94BF', '#8C94BF', '#D2D3DC', '#AB5468', '#5D6CAE', '#AB5468', '#D2B0B6', '#5D6CAE', '#8C94BF', '#D2D3DC', '#D2B0B6', '#5D6CAE', '#8E063B', '#8C94BF', '#DDD0D2', '#B3B7CF', '#D2D3DC', '#8E063B', '#8E063B', '#8E063B', '#E2E2E2', '#C18692', '#DDD0D2', '#5D6CAE', '#8E063B', '#D2B0B6', '#E2E2E2', '#B3B7CF', '#8E063B', '#AB5468', '#5D6CAE', '#5D6CAE', '#8C94BF', '#5D6CAE', '#8C94BF', '#D2B0B6', '#5D6CAE', '#B3B7CF', '#B3B7CF', '#AB5468', '#D2B0B6', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#C18692', '#B3B7CF', '#C18692', '#8C94BF', '#B3B7CF', '#DDD0D2', '#AB5468', '#D2D3DC', '#8E063B', '#B3B7CF', '#8E063B', '#D2B0B6', '#8C94BF', '#8E063B', '#AB5468', '#8E063B', '#8E063B', '#8E063B', '#D2D3DC', '#DDD0D2', '#5D6CAE', '#AB5468', '#D2D3DC', '#D2D3DC', '#AB5468', '#8C94BF', '#C18692', '#C18692', '#AB5468', '#D2D3DC', '#C18692', '#8E063B', '#D2B0B6', '#D2D3DC', '#AB5468', '#C18692', '#8C94BF', '#AB5468', '#8E063B', '#D2D3DC', '#E2E2E2', '#AB5468', '#8C94BF', '#DDD0D2', '#DDD0D2', '#AB5468', '#D2B0B6', '#C18692', '#D2B0B6', '#C18692', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#8E063B', '#D2B0B6', '#C18692', '#8E063B', '#B3B7CF', '#E2E2E2', '#8C94BF', '#C18692', '#5D6CAE', '#5D6CAE', '#8E063B', '#C18692', '#C18692', '#8E063B', '#D2B0B6', '#8E063B', '#C18692', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#8E063B', '#D2D3DC', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#B3B7CF', '#C18692', '#5D6CAE', '#B3B7CF', '#D2B0B6', '#8C94BF', '#D2D3DC', '#D2D3DC', '#5D6CAE', '#D2B0B6', '#5D6CAE', '#5D6CAE', '#AB5468', '#DDD0D2', '#8E063B', '#8E063B', '#8E063B', '#8E063B', '#D2B0B6', '#8E063B', '#8E063B', '#8E063B', '#C18692', '#8E063B', '#8E063B', '#D2D3DC', '#5D6CAE', '#D2D3DC', '#E2E2E2', '#8E063B', '#5D6CAE', '#5D6CAE', '#AB5468', '#8C94BF', '#D2D3DC', '#5D6CAE', '#C18692', '#8E063B', '#B3B7CF', '#023FA5', '#D2B0B6', '#8E063B', '#5D6CAE', '#5D6CAE', '#C18692', '#5D6CAE', '#B3B7CF', '#8C94BF', '#DDD0D2', '#5D6CAE', '#AB5468', '#8C94BF', '#AB5468', '#8E063B', '#8E063B', '#D2B0B6', '#D2D3DC', '#AB5468', '#8E063B', '#AB5468', '#8E063B', '#C18692', '#8E063B', '#8E063B', '#AB5468', '#AB5468', '#8E063B', '#B3B7CF', '#E2E2E2', '#8E063B', '#E2E2E2', '#B3B7CF', '#C18692', '#E2E2E2', '#5D6CAE', '#8C94BF', '#8C94BF', '#E2E2E2', '#8E063B', '#8E063B', '#5D6CAE', '#C18692', '#5D6CAE', '#5D6CAE', '#B3B7CF', '#5D6CAE', '#5D6CAE', '#8E063B', '#8C94BF', '#5D6CAE', '#B3B7CF', '#C18692', '#5D6CAE', '#8E063B', '#B3B7CF', '#AB5468', '#DDD0D2', '#C18692', '#C18692', '#AB5468', '#8C94BF', '#DDD0D2', '#8E063B', '#B3B7CF', '#D2B0B6', '#5D6CAE', '#8C94BF', '#B3B7CF', '#D2D3DC', '#B3B7CF', '#8C94BF', '#B3B7CF', '#8C94BF', '#8C94BF', '#D2B0B6', '#8E063B', '#B3B7CF', '#5D6CAE', '#DDD0D2', '#DDD0D2', '#C18692', '#5D6CAE', '#D2B0B6', '#8C94BF', '#023FA5', '#5D6CAE', '#8E063B', '#C18692', '#B3B7CF', '#8C94BF', '#D2B0B6', '#D2D3DC', '#8C94BF', '#B3B7CF', '#8E063B', '#B3B7CF', '#8C94BF', '#AB5468', '#AB5468', '#5D6CAE', '#8E063B', '#AB5468', '#AB5468', '#5D6CAE', '#DDD0D2', '#AB5468', '#AB5468', '#DDD0D2', '#8E063B', '#8E063B', '#D2B0B6', '#D2B0B6', '#C18692', '#D2B0B6', '#8C94BF', '#DDD0D2', '#DDD0D2', '#E2E2E2', '#5D6CAE', '#8C94BF', '#E2E2E2', '#5D6CAE', '#5D6CAE', '#5D6CAE', '#5D6CAE', '#D2D3DC', '#8C94BF', '#E2E2E2', '#DDD0D2', '#AB5468', '#8E063B', '#C18692', '#8E063B', '#8E063B', '#8E063B', '#AB5468', '#8E063B', '#8E063B', '#8C94BF', '#8E063B', '#AB5468', '#5D6CAE', '#8E063B', '#E2E2E2', '#5D6CAE', '#D2D3DC', '#C18692', '#B3B7CF', '#5D6CAE', '#8C94BF', '#E2E2E2', '#5D6CAE', '#5D6CAE', '#AB5468', '#D2D3DC', '#8C94BF', '#5D6CAE', '#D2B0B6', '#5D6CAE', '#E2E2E2', '#5D6CAE', '#8E063B', '#8C94BF', '#8C94BF', '#AB5468', '#8C94BF', '#D2D3DC', '#8E063B', '#8E063B', '#AB5468', '#D2B0B6', '#8E063B', '#C18692', '#8E063B', '#8E063B', '#AB5468', '#C18692', '#AB5468', '#DDD0D2', '#D2D3DC', '#8C94BF', '#E2E2E2', '#8C94BF', '#5D6CAE', '#5D6CAE', '#5D6CAE', '#023FA5', '#5D6CAE', '#5D6CAE' ];\\n    return residue_colors[atom.resi];\\n}\"}},\"sel\":{}},{\"method\":\"zoomTo\"}]},\"evals\":[],\"jsHooks\":[]} ## no AlphaFold prediction for this protein P35555 <-     am_data(\"aa_substitutions\") |>     dplyr::filter(uniprot_id == \"P35555\") tryCatch({     af_prediction_view(P35555) }, error = identity) #> <simpleError in af_prediction_view(P35555): 'af_prediction_view()' could not find UniProt accession 'P35555'>   ## af_colorfunc_by_position()  df <- tibble(     pos = 1 + 1:10, # no color information for position 1     value = 10:1 / 10 ) colorfunc <- af_colorfunc_by_position(     df,     \"pos\", \"value\",     pos_max = 12    # no color information for position 12 ) cat(colorfunc) #> function(atom) { #>     const residue_colors = [ 'gray', '#8E063B', '#AB5468', '#C18692', '#D2B0B6', '#DDD0D2', '#D2D3DC', '#B3B7CF', '#8C94BF', '#5D6CAE', '#023FA5', 'gray' ]; #>     return residue_colors[atom.resi]; #> }  ## template used for Javascript function cat(     AlphaMissenseR:::js_template(\"colorfunc\", colors = \"...\"),     \"\\n\" ) #> function(atom) { #>     const residue_colors = [ ... ]; #>     return residue_colors[atom.resi]; #> }"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":null,"dir":"Reference","previous_headings":"","what":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"ALPHAMISSENSE_RECORD constant identifier corresponding default version AlphaMissense resource use. am_browse() opens web browser Zenodo record AlphaMissense data. am_available() reports available datasets record. am_data() retrieves single key AlpahMissense Zenodo site parses file DuckDB database.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"","code":"ALPHAMISSENSE_RECORD  am_browse(record = ALPHAMISSENSE_RECORD)  am_available(record = ALPHAMISSENSE_RECORD, bfc = BiocFileCache())  am_data(     key,     record = ALPHAMISSENSE_RECORD,     bfc = BiocFileCache(),     as = c(\"tbl\", \"tsv\") )"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"object class character length 1.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"record character(1) Zenodo record AlphaMissense data resources. bfc object returned BiocFileCache() representing location downloaded files parsed database stored. default 'global' BiocFileCache. key character(1) 'key' result am_available(), single row tibble returned am_available(). chracter(1) type return value. \"tbl\": dbplyr tbl representation database resource. \"tsv\": path tsv.gz file representing resource downloaded Zenodo","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"am_available() returns tibble columns key, size, link. meaning key must determined reference information am_browse(). am_data() returns dbplyr (database) tibble represented downloaded parsed file. Fields database described Zenodo resource page.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"ALPHAMISSENSE_RECORD can set package loaded environment variable name, e.g., Sys.setenv(ALPHAMISSENSE_RECORD = \"10813168\"). default recent version (version 3) checked 11 April, 2024. am_data() uses BiocFileCache download store file corresponding DuckDB database.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/AlphaMissense.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Retrieve AlphaMissense Resources as DuckDB Databases — ALPHAMISSENSE_RECORD","text":"","code":"ALPHAMISSENSE_RECORD #> [1] \"10813168\"  if (interactive())     am_browse()  am_available() #> # A tibble: 7 × 6 #>   record   key                             size cached filename            link  #>   <chr>    <chr>                          <dbl> <lgl>  <chr>               <chr> #> 1 10813168 gene_hg38                     253636 TRUE   AlphaMissense_gene… http… #> 2 10813168 isoforms_hg38             1177361934 FALSE  AlphaMissense_isof… http… #> 3 10813168 isoforms_aa_substitutions 2461351945 FALSE  AlphaMissense_isof… http… #> 4 10813168 hg38                       642961469 TRUE   AlphaMissense_hg38… http… #> 5 10813168 hg19                       622293310 FALSE  AlphaMissense_hg19… http… #> 6 10813168 gene_hg19                     243943 FALSE  AlphaMissense_gene… http… #> 7 10813168 aa_substitutions          1207278510 TRUE   AlphaMissense_aa_s… http…  am_data(\"hg38\") #> # Source:   table<hg38> [?? x 10] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr> <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr1  69094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L             #>  2 chr1  69094 G     C     hg38   Q8NH21     ENST00000335137.4 V2L             #>  3 chr1  69094 G     A     hg38   Q8NH21     ENST00000335137.4 V2M             #>  4 chr1  69095 T     C     hg38   Q8NH21     ENST00000335137.4 V2A             #>  5 chr1  69095 T     A     hg38   Q8NH21     ENST00000335137.4 V2E             #>  6 chr1  69095 T     G     hg38   Q8NH21     ENST00000335137.4 V2G             #>  7 chr1  69097 A     G     hg38   Q8NH21     ENST00000335137.4 T3A             #>  8 chr1  69097 A     C     hg38   Q8NH21     ENST00000335137.4 T3P             #>  9 chr1  69097 A     T     hg38   Q8NH21     ENST00000335137.4 T3S             #> 10 chr1  69098 C     A     hg38   Q8NH21     ENST00000335137.4 T3N             #> # ℹ more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr>  ## close the connection opened when adding the data db_disconnect()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":null,"dir":"Reference","previous_headings":"","what":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"clinvar_data() loads ClinVar information supplemental table AlphaMissense [2023] paper. clinvar_plot() integrates ClinVar classifications AlphaMissense predicted scores derived am_data(\"aa_substitutions\") returns ggplot object visualization.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"","code":"clinvar_data(record = ALPHAMISSENSE_RECORD, bfc = BiocFileCache())  clinvar_plot(uniprotId, alphamissense_table, clinvar_table)"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"record character(1) Zenodo record AlphaMissense data resources. bfc object returned BiocFileCache() representing location AlphaMissenseR database. default 'global' BiocFileCache. uniprotId character() valid UniProt accession identifier. alphamissense_table table containing AlphaMissense predictions protein variants. default, table derived am_data(\"aa_substitution\"). Alternatively, user-defined tibble::tbl_df data.frame can supplied. clinvar_table table containing ClinVar information. default, table derived supplemental data AlphaMissense paper. Alternatively, user-defined tibble::tbl_df data.frame can supplied.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"clinvar_data() returns tbl 82872 rows 5 variables: variant_id: ClinVar variant identifier. transcript_id: Ensembl transcript identifier. protein_variant: UniProt accession:protein variant identifier. AlphaMissense: AlphaMissense pathogenicity score. label: Binary ClinVar class, either \"benign\" \"pathogenic\". clinvar_plot() returns ggplot object overlays ClinVar classifications onto AlphaMissense predicted scores. Blue, gray, red colors represent pathogenicity classifications \"likely benign\", \"ambiguous\", \"likely pathogenic\", respectively. Large, bolded points ClinVar variants colored according clinical classification, smaller points background AlphaMissense predictions.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"clinvar_plot(),  alphamissense_table columns must include: uniprot_id: UniProt accession identifier. protein_variant: variant identifier string, protein position middle, reference mutant amino acid residues left right position, respectively. am_class: AlphaMissense classification either \"benign\", \"ambiguous\", \"pathogenic\". am_pathogenicity: AlphaMissense predicted score. clinvar_table columns must include: uniprot_id: UniProt accession identifier, matching alphamissense_table. protein_variant: variant identifier string, matching alphamissense_table format. cv_class: binary ClinVar classification \"benign\" \"pathogenic\".","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":"references","dir":"Reference","previous_headings":"","what":"References","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"Cheng et al., Accurate proteome-wide missense variant effect prediction AlphaMissense. Science 381, eadg7492. DOI:10.1126/science.adg7492.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/ClinVar.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Integrate ClinVar Labels with AlphaMissense Pathogenicity Scores — clinvar_data","text":"","code":"clinvar_data() #> # Source:   table<clinvar> [?? x 5] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>    variant_id           transcript_id     protein_variant AlphaMissense label  #>    <chr>                <chr>             <chr>                   <dbl> <fct>  #>  1 chr1_925969_C_T_hg38 ENST00000342066.8 Q96NU1:P10S            0.967  benign #>  2 chr1_930165_G_A_hg38 ENST00000342066.8 Q96NU1:R28Q            0.663  benign #>  3 chr1_930204_G_A_hg38 ENST00000342066.8 Q96NU1:R41Q            0.0866 benign #>  4 chr1_930245_G_A_hg38 ENST00000342066.8 Q96NU1:D55N            0.134  benign #>  5 chr1_930248_G_A_hg38 ENST00000342066.8 Q96NU1:G56S            0.100  benign #>  6 chr1_930282_G_A_hg38 ENST00000342066.8 Q96NU1:R67Q            0.0635 benign #>  7 chr1_930285_G_A_hg38 ENST00000342066.8 Q96NU1:R68Q            0.0629 benign #>  8 chr1_930314_C_T_hg38 ENST00000342066.8 Q96NU1:H78Y            0.110  benign #>  9 chr1_930320_C_T_hg38 ENST00000342066.8 Q96NU1:R80C            0.0918 benign #> 10 chr1_931058_G_A_hg38 ENST00000342066.8 Q96NU1:V92M            0.196  benign #> # ℹ more rows  alphamissense_table <- am_data(\"aa_substitutions\")  clinvar_plot(     uniprotId = \"P37023\",     alphamissense_table = alphamissense_table ) #> * [11:38:21][info] 'clinvar_table' not provided, using default ClinVar dataset in AlphaMissenseR package"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/GenomicRanges.html","id":null,"dir":"Reference","previous_headings":"","what":"Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos","title":"Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos","text":"to_GPos() coerces tibble derived am_data(\"hg19\") am_data(\"hg38\") resources GenomicRanges GPos objects.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/GenomicRanges.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos","text":"","code":"to_GPos(tbl)"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/GenomicRanges.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos","text":"tbl tibble derived am_data(\"hg19\") am_data(\"hg38\"). tibble must columns CHROM, POS, genome.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/GenomicRanges.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos","text":"to_GPos() returns GPos object, can used GRanges object range-based filtering annotation","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/GenomicRanges.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Create GenomicRanges Objects from AlphaMissense Annotations — to_GPos","text":"","code":"am_data(\"hg38\") |>     filter(CHROM == \"chr2\", POS < 10000000, REF == \"G\") |>     select(-REF) |>     to_GPos() #> UnstitchedGPos object with 26751 positions and 6 metadata columns: #>           seqnames       pos strand |         ALT  uniprot_id #>              <Rle> <integer>  <Rle> | <character> <character> #>       [1]     chr2     41613      * |           C      Q1W6H9 #>       [2]     chr2     41615      * |           C      Q1W6H9 #>       [3]     chr2     41615      * |           A      Q1W6H9 #>       [4]     chr2     41615      * |           T      Q1W6H9 #>       [5]     chr2     41618      * |           C      Q1W6H9 #>       ...      ...       ...    ... .         ...         ... #>   [26747]     chr2   9999028      * |           A      Q9NZI5 #>   [26748]     chr2   9999028      * |           T      Q9NZI5 #>   [26749]     chr2   9999029      * |           C      Q9NZI5 #>   [26750]     chr2   9999029      * |           A      Q9NZI5 #>   [26751]     chr2   9999029      * |           T      Q9NZI5 #>                transcript_id protein_variant am_pathogenicity          am_class #>                  <character>     <character>        <numeric>       <character> #>       [1]  ENST00000327669.5           R321G           0.0848     likely_benign #>       [2]  ENST00000327669.5           S320C           0.0946     likely_benign #>       [3]  ENST00000327669.5           S320F           0.1593     likely_benign #>       [4]  ENST00000327669.5           S320Y           0.1429     likely_benign #>       [5]  ENST00000327669.5           P319R           0.0765     likely_benign #>       ...                ...             ...              ...               ... #>   [26747] ENST00000324907.14           G581R           0.9997 likely_pathogenic #>   [26748] ENST00000324907.14           G581W           0.9996 likely_pathogenic #>   [26749] ENST00000324907.14           G581A           0.9970 likely_pathogenic #>   [26750] ENST00000324907.14           G581E           0.9995 likely_pathogenic #>   [26751] ENST00000324907.14           G581V           0.9994 likely_pathogenic #>   ------- #>   seqinfo: 25 sequences (1 circular) from hg38 genome"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/Gosling.html","id":null,"dir":"Reference","previous_headings":"","what":"Plot a GPos or GRanges Object Using Shiny and Gosling — gosling_plot","title":"Plot a GPos or GRanges Object Using Shiny and Gosling — gosling_plot","text":"plot_granges() creates Shiny app displays Gosling plot given GRanges object.  visualizes genomic ranges rectangle point representations, allows customization plot title subtitle.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/Gosling.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Plot a GPos or GRanges Object Using Shiny and Gosling — gosling_plot","text":"","code":"gosling_plot(   granges,   title = \"GRanges Plot\",   subtitle = \"Stacked nucleotide example\",   plot_type = c(\"bar\", \"lollipop\"),   create_app = interactive() )"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/Gosling.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Plot a GPos or GRanges Object Using Shiny and Gosling — gosling_plot","text":"granges GenomicRanges::GRanges (e.g., GenomicRanges::GPos) object containing genomic ranges plotted. title character(1) Title plot. Default \"GRanges Plot\". subtitle character(1) subtitle plot. Default \"Stacked nucleotide example\". plot_type character(1) Select type gosling plot. Default \"bar\"; available types described Details. create_app logical(1) Produce Shiny app Gosling visualization. Default TRUE used interactively.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/Gosling.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Plot a GPos or GRanges Object Using Shiny and Gosling — gosling_plot","text":"gosling_plot() create_app = TRUE returns shinyApp object , run, displays Gosling plot. create_app = FALSE, (invisible) return value represents gosling object used Shiny apps.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/Gosling.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Plot a GPos or GRanges Object Using Shiny and Gosling — gosling_plot","text":"function supports 2 types plots selected plot_type argument: (1) \"bar\": barplot-like view pathogenicity score position, similar sequencing coverage plot, (2) \"lollipop\": lollipop plot focusing pathogenicity classification (ambiguous, benign, pathogenic) position. requires GenomicRanges::GRanges object following metadata columns: 'am_class' (effect classification),'am_pathogenicity' (pathogenicity score), 'ALT' (alternative allele) 'REF' (reference allele).","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/Gosling.html","id":"note","dir":"Reference","previous_headings":"","what":"Note","title":"Plot a GPos or GRanges Object Using Shiny and Gosling — gosling_plot","text":"function requires shiny, shiny.gosling, GenomicRanges packages installed.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/Gosling.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Plot a GPos or GRanges Object Using Shiny and Gosling — gosling_plot","text":"","code":"## Create a sample GRanges object from AlphamissenseR gpos <-     am_data(\"hg38\") |>     filter(uniprot_id == \"Q1W6H9\") |>     to_GPos()  ## Plot `gpos` using shiny.gosling if (requireNamespace(\"shiny.gosling\", quietly = TRUE)) {    gosling_plot(        gpos, title = \"Q1W6H_track\", subtitle = \"bar plot example\",        plot_type = \"bar\", create_app = FALSE    ) }"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html","id":null,"dir":"Reference","previous_headings":"","what":"Common Amino Acid-level Transformations — am_aa_pos","title":"Common Amino Acid-level Transformations — am_aa_pos","text":"am_aa_pos() separates protein_variant columns amino acide 'pos', 'ref', 'alt' columns. am_aa_pathogenicity() summarizes pathogenicity scores protein amino acid position.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Common Amino Acid-level Transformations — am_aa_pos","text":"","code":"am_aa_pos(tbl)  am_aa_pathogenicity(tbl)"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Common Amino Acid-level Transformations — am_aa_pos","text":"tbl tibble, usually derived am_data(\"aa_substitutions\"), `am_data(\"hg38\"), etc. See details.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Common Amino Acid-level Transformations — am_aa_pos","text":"am_aa_pos() returns original table additional columns aa_pos: position protein variant, integer(). aa_ref: single-character reference amino acid protein variant. aa_alt: single-character alternate amino acid protein variant. am_aa_pathogenicity() returns tibble columns uniprot_id, aa_pos, aa_ref: UniProt id, position reference amino acid summarized aa_pathogenicity_n, aa_pathogenicity_mean, aa_pathogenicity_median, aa_pathogenicity_min, aa_pathogenicity_max: number, average, median, minimum, maximum pathogenicity scores amino acid position. aa_pathogenicity_mode: modal am_class amino acid position, factor. Tied mode assigned lower pathogenicity.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Common Amino Acid-level Transformations — am_aa_pos","text":"tbl collect()ed computation, rows must fit memory. am_aa_pos(), tbl must contain column protein_variant entries form \"Q465H\", AlphaMissense data. am_aa_pathogenicity(), tbl must contain columns uniprot_id, protein_variant, am_pathogenicity am_class. am_pos friends already calculated, am_aa_pos() called.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/am_aa.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Common Amino Acid-level Transformations — am_aa_pos","text":"","code":"P35557 <-     am_data(\"hg38\") |>     filter(uniprot_id %in% \"P35557\")  am_aa_pos(P35557) #> # A tibble: 3,085 × 13 #>    CHROM      POS REF   ALT   genome uniprot_id transcript_id    protein_variant #>    <chr>    <dbl> <chr> <chr> <chr>  <chr>      <chr>            <chr>           #>  1 chr7  44145139 C     A     hg38   P35557     ENST00000403799… Q465H           #>  2 chr7  44145139 C     G     hg38   P35557     ENST00000403799… Q465H           #>  3 chr7  44145140 T     C     hg38   P35557     ENST00000403799… Q465R           #>  4 chr7  44145140 T     A     hg38   P35557     ENST00000403799… Q465L           #>  5 chr7  44145140 T     G     hg38   P35557     ENST00000403799… Q465P           #>  6 chr7  44145141 G     C     hg38   P35557     ENST00000403799… Q465E           #>  7 chr7  44145141 G     T     hg38   P35557     ENST00000403799… Q465K           #>  8 chr7  44145143 C     G     hg38   P35557     ENST00000403799… G464A           #>  9 chr7  44145143 C     T     hg38   P35557     ENST00000403799… G464D           #> 10 chr7  44145143 C     A     hg38   P35557     ENST00000403799… G464V           #> # ℹ 3,075 more rows #> # ℹ 5 more variables: am_pathogenicity <dbl>, am_class <chr>, aa_pos <int>, #> #   aa_ref <chr>, aa_alt <chr>  am_aa_pos(P35557) |>     select(         uniprot_id, POS, REF, ALT, protein_variant,         starts_with(\"aa_\"), am_pathogenicity, am_class     ) |>     arrange(aa_pos) #> # A tibble: 3,085 × 10 #>    uniprot_id      POS REF   ALT   protein_variant aa_pos aa_ref aa_alt #>    <chr>         <dbl> <chr> <chr> <chr>            <int> <chr>  <chr>  #>  1 P35557     44188949 A     C     L2R                  2 L      R      #>  2 P35557     44188949 A     T     L2Q                  2 L      Q      #>  3 P35557     44188949 A     G     L2P                  2 L      P      #>  4 P35557     44188950 G     T     L2M                  2 L      M      #>  5 P35557     44188950 G     C     L2V                  2 L      V      #>  6 P35557     44188945 G     C     D3E                  3 D      E      #>  7 P35557     44188945 G     T     D3E                  3 D      E      #>  8 P35557     44188946 T     G     D3A                  3 D      A      #>  9 P35557     44188946 T     C     D3G                  3 D      G      #> 10 P35557     44188946 T     A     D3V                  3 D      V      #> # ℹ 3,075 more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr>   am_aa_pathogenicity(P35557) #> # A tibble: 464 × 9 #>    uniprot_id aa_pos aa_ref aa_pathogenicity_n aa_pathogenicity_mean #>    <chr>       <int> <chr>               <int>                 <dbl> #>  1 P35557          2 L                       5                0.0818 #>  2 P35557          3 D                       8                0.184  #>  3 P35557          4 D                       8                0.147  #>  4 P35557          5 R                       6                0.250  #>  5 P35557          6 A                       6                0.138  #>  6 P35557          7 R                       7                0.257  #>  7 P35557          8 M                       9                0.142  #>  8 P35557          9 E                       7                0.212  #>  9 P35557         10 A                       6                0.142  #> 10 P35557         11 A                       6                0.142  #> # ℹ 454 more rows #> # ℹ 4 more variables: aa_pathogenicity_median <dbl>, #> #   aa_pathogenicity_min <dbl>, aa_pathogenicity_max <dbl>, #> #   aa_pathogenicity_mode <fct>"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/db.html","id":null,"dir":"Reference","previous_headings":"","what":"Manipulate the Database of Missense Mutations — db_connect","title":"Manipulate the Database of Missense Mutations — db_connect","text":"db_connect() manages connections AlphaMissense record-specific databases. default, connections created reused. db_tables() queries names temporary regular tables defined database. db_temporary_table() creates temporary (duration duckdb connection) table tibble. db_range_join() performs range join, finding positions key within ranges defined join. result stored table . db_disconnect() disconnects duckdb database shuts DuckDB server associated connection. Temporary tables lost. db_disconnect_all() disconnects managed duckdb database connection.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/db.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Manipulate the Database of Missense Mutations — db_connect","text":"","code":"db_connect(     record = ALPHAMISSENSE_RECORD,     bfc = BiocFileCache(),     read_only = TRUE,     managed = read_only )  db_tables(db = db_connect())  db_temporary_table(db, value, to)  db_range_join(db, key, join, to)  db_disconnect(db = db_connect())  db_disconnect_all()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/db.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Manipulate the Database of Missense Mutations — db_connect","text":"record character(1) Zenodo record AlphaMissense data resources. bfc object returned BiocFileCache() representing location downloaded files parsed database stored. default 'global' BiocFileCache. read_only logical(1) open connection 'read '. TRUE protects overwriting existing data default. managed logical(1) TRUE, re-use existing managed connection database. db duckdb_connection object, returned db_connect(). value data.frame / tibble containing data placed temporary table, e.g., GenomicRanges object used range join. character(1) name table created key character(1) table name db containing missense mutation coordinates. join character(1) table name db containing ranges used joining (filtering) key.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/db.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Manipulate the Database of Missense Mutations — db_connect","text":"db_connect() returns open duckdb_connection AlphaMissense record-specific database. db_tables() returns character vector database table names. db_temporary_table() returns temporary table dbplyr tibble. db_range_join() returns (temporary table created join) dbplyr tibble. db_disconnect() returns FALSE connection already closed valid (via dbIsValid()) TRUE disconnection successful. Values returned invisibly. db_disconnect_all() returns db_disconnect() value connection, invisibly.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/db.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Manipulate the Database of Missense Mutations — db_connect","text":"db_connect(), set managed = FALSE , instance, accessing database separate process. Remember capture database connection db_unmanaged <- db_connect(managed = FALSE) disconnect done `db_disconnect(db_unmanaged). Connections managed default. db_temporary_table() overwrites existing table name . db_range_join() overwrites existing table . table key usually \"hg19\" \"hg38\" must CHROM POS columns. table join must columns CHROM, start end. Following Bioconductor convention reported am_browse(), coordinates 1-based ranges defined start end closed. columns key join included, column names (CHROM) duplicated. db_disconnect() called unmanaged connection, (free default managed connection) end session.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/reference/db.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Manipulate the Database of Missense Mutations — db_connect","text":"","code":"db_connect()          # default 'read-only' connection #> alphamissense_connection (read_only: TRUE; managed: TRUE) #> record: '10813168' #> connected: TRUE #> tables: aa_substitutions, clinvar, gene_hg38, hg38  db_rw <- db_connect(read_only = FALSE)  am_data(\"hg38\")       # uses the default, 'read-only' connection #> # Source:   table<hg38> [?? x 10] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>    CHROM   POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr> <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr1  69094 G     T     hg38   Q8NH21     ENST00000335137.4 V2L             #>  2 chr1  69094 G     C     hg38   Q8NH21     ENST00000335137.4 V2L             #>  3 chr1  69094 G     A     hg38   Q8NH21     ENST00000335137.4 V2M             #>  4 chr1  69095 T     C     hg38   Q8NH21     ENST00000335137.4 V2A             #>  5 chr1  69095 T     A     hg38   Q8NH21     ENST00000335137.4 V2E             #>  6 chr1  69095 T     G     hg38   Q8NH21     ENST00000335137.4 V2G             #>  7 chr1  69097 A     G     hg38   Q8NH21     ENST00000335137.4 T3A             #>  8 chr1  69097 A     C     hg38   Q8NH21     ENST00000335137.4 T3P             #>  9 chr1  69097 A     T     hg38   Q8NH21     ENST00000335137.4 T3S             #> 10 chr1  69098 C     A     hg38   Q8NH21     ENST00000335137.4 T3N             #> # ℹ more rows #> # ℹ 2 more variables: am_pathogenicity <dbl>, am_class <chr> db_tables()           # connections initially share the same tables #> [1] \"aa_substitutions\" \"clinvar\"          \"gene_hg38\"        \"hg38\"             db_tables(db_rw) #> [1] \"aa_substitutions\" \"clinvar\"          \"gene_hg38\"        \"hg38\"              ## ranges of interest -- the first 200000 bases on chromsomes 1-4. ranges <- tibble(     CHROM = paste0(\"chr\", 1:4),     start = rep(1, 4),     end = rep(200000, 4) ) db_temporary_table(db_rw, ranges, \"ranges\") #> # Source:   table<ranges> [4 x 3] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>   CHROM start    end #>   <chr> <dbl>  <dbl> #> 1 chr1      1 200000 #> 2 chr2      1 200000 #> 3 chr3      1 200000 #> 4 chr4      1 200000  db_tables(db_rw)      # temporary table available to the db_rw connection... #> [1] \"aa_substitutions\" \"clinvar\"          \"gene_hg38\"        \"hg38\"             #> [5] \"ranges\"           db_tables()           # ...but not to the read-only connection #> [1] \"aa_substitutions\" \"clinvar\"          \"gene_hg38\"        \"hg38\"              rng <- db_range_join(db_rw, \"hg38\", \"ranges\", \"ranges_overlaps\") rng #> # Source:   table<ranges_overlaps> [?? x 12] #> # Database: DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #>    CHROM    POS REF   ALT   genome uniprot_id transcript_id     protein_variant #>    <chr>  <dbl> <chr> <chr> <chr>  <chr>      <chr>             <chr>           #>  1 chr4  161194 C     G     hg38   Q3SXZ3     ENST00000510175.6 T170S           #>  2 chr4  161196 T     A     hg38   Q3SXZ3     ENST00000510175.6 F171I           #>  3 chr4  161196 T     C     hg38   Q3SXZ3     ENST00000510175.6 F171L           #>  4 chr4  161196 T     G     hg38   Q3SXZ3     ENST00000510175.6 F171V           #>  5 chr4  161197 T     G     hg38   Q3SXZ3     ENST00000510175.6 F171C           #>  6 chr4  161197 T     C     hg38   Q3SXZ3     ENST00000510175.6 F171S           #>  7 chr4  161197 T     A     hg38   Q3SXZ3     ENST00000510175.6 F171Y           #>  8 chr4  161198 T     A     hg38   Q3SXZ3     ENST00000510175.6 F171L           #>  9 chr4  161198 T     G     hg38   Q3SXZ3     ENST00000510175.6 F171L           #> 10 chr4  161199 A     C     hg38   Q3SXZ3     ENST00000510175.6 K172Q           #> # ℹ more rows #> # ℹ 4 more variables: am_pathogenicity <dbl>, am_class <chr>, start <dbl>, #> #   end <dbl> rng |>     count(CHROM) |>     arrange(CHROM) #> # Source:     SQL [3 x 2] #> # Database:   DuckDB v1.0.0 [root@Darwin 23.6.0:R 4.5.0//Users/mtmorgan/Library/Caches/org.R-project.R/R/BiocFileCache/121787f1dafbc_121787f1dafbc] #> # Ordered by: CHROM #>   CHROM     n #>   <chr> <dbl> #> 1 chr1   2018 #> 2 chr2   2028 #> 3 chr4   7488  db_disconnect(db_rw)  # explicit read-write connection db_disconnect()       # implicit read-only connection  db_disconnect_all()"},{"path":"https://mtmorgan.github.io/AlphaMissenseR/news/index.html","id":"alphamissenser-120","dir":"Changelog","previous_headings":"","what":"AlphaMissenseR 1.2.0","title":"AlphaMissenseR 1.2.0","text":"(v. 1.1.6) Add gosling_plot() visualizing variants bar lollipop plots (v. 1.1.4) Add clinvar_data() clinvar_plot() visualizing ClinVar data. Merges https://github.com/mtmorgan/AlphaMissenseR/pull/4 Thanks @tram-nguyen-n (v. 1.1.2) af_predictions() returns tibble 21 columns, instead 20. Merges https://github.com/mtmorgan/AlphaMissenseR/pull/3.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/news/index.html","id":"alphamissenser-100","dir":"Changelog","previous_headings":"","what":"AlphaMissenseR 1.0.0","title":"AlphaMissenseR 1.0.0","text":"(v. 0.99.21) Update Zenodo data source record 10813168, accessible ‘CC--4.0’ license. Order vignettes introduction, visualization, issues. Use rjsoncons (>= 1.0.1), jsonlite hard dependency. Acknowledge additional funding sources; add ImmunoOncology biocViews term. Use BiocBaseUtils input assertions. Include range join SQL directly rather via non-exported function. Report file size downloading. Improve test coverage. See GitHub issue comment; thanks @LiNk-NY (v. 0.99.11) Use S4 class alphamissense_connection, extending duckdb_connection. (v. 0.99.10) Introduce visualization AlphaFold predictions. (v. 0.99.9) Update maintainer email address, add ‘Resource unavailable’ section ‘Issues & Solutions’ vignette. (v. 0.99.7) Update revised Zenodo API. (v. 0.99.5) BREAKING change. Requires duckdb >= 0.9.1, read DuckDB databases created earlier versions. Also introduces changes local cache naming. See ‘Issues & Solutions’ vignette. (v. 0.99.4) Change back Bioconductor ‘Software’ package, allow regular testing data access code. (v. 0.99.1) Change Bioconductor ‘Annotation’ package. (v. 0.99.1) Update change Zenodo API.","code":""},{"path":"https://mtmorgan.github.io/AlphaMissenseR/news/index.html","id":"alphamissenser-0990","dir":"Changelog","previous_headings":"","what":"AlphaMissenseR 0.99.0","title":"AlphaMissenseR 0.99.0","text":"(v. 0.0.18) Rename (including updating existing tables) ‘#CHROM’ ‘CHROM’ hg19 / hg38 tables (v. 0.0.17) Initial Bioconductor submission.","code":""}]
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