diff --git a/CHANGELOG.md b/CHANGELOG.md
index e7e1480a..31781c81 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -18,6 +18,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - Installed the nf-core version of the sentieon/datametrics module [#400](https://github.com/nf-core/raredisease/pull/400)
 - Installed the nf-core version of the sentieon/dedup module. The dedup module also contains a call to Sentieon's LocusCollector [#401](https://github.com/nf-core/raredisease/pull/401)
 - Removing Sentieon-based BQSR. Recent Illumina sequencers tend to provide well-calibrated BQs, so BQSR may not provide much benefit [#402](https://github.com/nf-core/raredisease/pull/402)
+- Installed the nf-core version of the sentieon/dnamodelapply module [#403](https://github.com/nf-core/raredisease/pull/403)
 
 ### `Fixed`
 
diff --git a/modules.json b/modules.json
index 9e427d30..b4e2c848 100644
--- a/modules.json
+++ b/modules.json
@@ -360,6 +360,11 @@
                         "git_sha": "915a0b16ba3e40ef59e7b44843b3118e17a9c906",
                         "installed_by": ["modules"]
                     },
+                    "sentieon/dnamodelapply": {
+                        "branch": "master",
+                        "git_sha": "43ef68091a1188fd8dc4c03f9341b556803c7514",
+                        "installed_by": ["modules"]
+                    },
                     "sentieon/readwriter": {
                         "branch": "master",
                         "git_sha": "b28e4dde755117e8dab5d6e85e292f145b8b53c3",
diff --git a/modules/local/sentieon/dnamodelapply.nf b/modules/local/sentieon/dnamodelapply.nf
deleted file mode 100644
index 32582b2c..00000000
--- a/modules/local/sentieon/dnamodelapply.nf
+++ /dev/null
@@ -1,50 +0,0 @@
-process SENTIEON_DNAMODELAPPLY {
-    tag "$meta.id"
-    label 'process_high'
-    label 'sentieon'
-
-    input:
-    tuple val(meta), path(vcf), path(vcf_idx)
-    tuple val(meta2), path(fasta)
-    tuple val(meta3), path(fai)
-    path ml_model
-
-    output:
-    tuple val(meta), path("*.vcf.gz")                      , emit: vcf
-    tuple val(meta), path("*.vcf.gz.tbi")                  , emit: index
-    tuple val(meta), path("*.vcf.gz"), path("*.vcf.gz.tbi"), emit: vcf_index
-    path "versions.yml"                                    , emit: versions
-
-    when:
-    task.ext.when == null || task.ext.when
-
-    script:
-    def prefix = task.ext.prefix ?: "${meta.id}"
-
-    """
-    sentieon driver \\
-        -t $task.cpus \\
-        -r $fasta \\
-        --algo DNAModelApply \\
-        --model $ml_model \\
-        -v $vcf \\
-        ${prefix}.vcf.gz
-
-    cat <<-END_VERSIONS > versions.yml
-    "${task.process}":
-        sentieon: \$(echo \$(sentieon driver --version 2>&1) | sed -e "s/sentieon-genomics-//g")
-    END_VERSIONS
-    """
-
-    stub:
-    def prefix = task.ext.prefix ?: "${meta.id}"
-    """
-    touch ${prefix}.vcf.gz
-    touch ${prefix}.vcf.gz.tbi
-
-    cat <<-END_VERSIONS > versions.yml
-    "${task.process}":
-        sentieon: \$(echo \$(sentieon driver --version 2>&1) | sed -e "s/sentieon-genomics-//g" )
-    END_VERSIONS
-    """
-}
diff --git a/modules/nf-core/sentieon/dnamodelapply/main.nf b/modules/nf-core/sentieon/dnamodelapply/main.nf
new file mode 100644
index 00000000..3fe9a28f
--- /dev/null
+++ b/modules/nf-core/sentieon/dnamodelapply/main.nf
@@ -0,0 +1,81 @@
+process SENTIEON_DNAMODELAPPLY {
+    tag "$meta.id"
+    label 'process_high'
+    label 'sentieon'
+
+    secret 'SENTIEON_LICENSE_BASE64'
+
+    container 'nf-core/sentieon:202112.06'
+
+    input:
+    tuple val(meta), path(vcf), path(idx)
+    tuple val(meta2), path(fasta)
+    tuple val(meta3), path(fai)
+    tuple val(meta4), path(ml_model)
+
+    output:
+    tuple val(meta), path("*.vcf.gz")    , emit: vcf
+    tuple val(meta), path("*.vcf.gz.tbi"), emit: index
+    path "versions.yml"                  , emit: versions
+
+    when:
+    task.ext.when == null || task.ext.when
+
+    script:
+    // Exit if running this module with -profile conda / -profile mamba
+    if (workflow.profile.tokenize(',').intersect(['conda', 'mamba']).size() >= 1) {
+        error "Sentieon modules do not support Conda. Please use Docker / Singularity / Podman instead."
+    }
+    def args      = task.ext.args   ?: ''
+    def prefix    = task.ext.prefix ?: "${meta.id}"
+    def sentieon_auth_mech_base64 = task.ext.sentieon_auth_mech_base64 ?: ''
+    def sentieon_auth_data_base64 = task.ext.sentieon_auth_data_base64 ?: ''
+
+    """
+    if [ "\${#SENTIEON_LICENSE_BASE64}" -lt "1500" ]; then  # If the string SENTIEON_LICENSE_BASE64 is short, then it is an encrypted url.
+        export SENTIEON_LICENSE=\$(echo -e "\$SENTIEON_LICENSE_BASE64" | base64 -d)
+    else  # Localhost license file
+        # The license file is stored as a nextflow variable like, for instance, this:
+        # nextflow secrets set SENTIEON_LICENSE_BASE64 \$(cat <sentieon_license_file.lic> | base64 -w 0)
+        export SENTIEON_LICENSE=\$(mktemp)
+        echo -e "\$SENTIEON_LICENSE_BASE64" | base64 -d > \$SENTIEON_LICENSE
+    fi
+
+    if  [ ${sentieon_auth_mech_base64} ] && [ ${sentieon_auth_data_base64} ]; then
+        # If sentieon_auth_mech_base64 and sentieon_auth_data_base64 are non-empty strings, then Sentieon is mostly likely being run with some test-license.
+        export SENTIEON_AUTH_MECH=\$(echo -n "${sentieon_auth_mech_base64}" | base64 -d)
+        export SENTIEON_AUTH_DATA=\$(echo -n "${sentieon_auth_data_base64}" | base64 -d)
+        echo "Decoded and exported Sentieon test-license system environment variables"
+    fi
+
+    sentieon driver \\
+        -t $task.cpus \\
+        -r $fasta \\
+        $args \\
+        --algo DNAModelApply \\
+        --model $ml_model \\
+        -v $vcf \\
+        ${prefix}.vcf.gz
+
+    cat <<-END_VERSIONS > versions.yml
+    "${task.process}":
+        sentieon: \$(echo \$(sentieon driver --version 2>&1) | sed -e "s/sentieon-genomics-//g")
+    END_VERSIONS
+    """
+
+    stub:
+    def prefix = task.ext.prefix ?: "${meta.id}"
+    // Exit if running this module with -profile conda / -profile mamba
+    if (workflow.profile.tokenize(',').intersect(['conda', 'mamba']).size() >= 1) {
+        error "Sentieon modules do not support Conda. Please use Docker / Singularity / Podman instead."
+    }
+    """
+    touch ${prefix}.vcf.gz
+    touch ${prefix}.vcf.gz.tbi
+
+    cat <<-END_VERSIONS > versions.yml
+    "${task.process}":
+        sentieon: \$(echo \$(sentieon driver --version 2>&1) | sed -e "s/sentieon-genomics-//g" )
+    END_VERSIONS
+    """
+}
diff --git a/modules/nf-core/sentieon/dnamodelapply/meta.yml b/modules/nf-core/sentieon/dnamodelapply/meta.yml
new file mode 100644
index 00000000..ec429bea
--- /dev/null
+++ b/modules/nf-core/sentieon/dnamodelapply/meta.yml
@@ -0,0 +1,78 @@
+name: "sentieon_dnamodelapply"
+description: modifies the input VCF file by adding the MLrejected FILTER to the variants
+keywords:
+  - dnamodelapply
+  - vcf
+  - filter
+  - sentieon
+tools:
+  - sentieon:
+      description: |
+        Sentieon® provides complete solutions for secondary DNA/RNA analysis for a variety of sequencing platforms, including short and long reads.
+        Our software improves upon BWA, STAR, Minimap2, GATK, HaplotypeCaller, Mutect, and Mutect2 based pipelines and is deployable on any generic-CPU-based computing system.
+      homepage: https://www.sentieon.com/
+      documentation: https://www.sentieon.com/
+
+input:
+  - meta:
+      type: map
+      description: |
+        Groovy Map containing sample information
+        e.g. `[ id:'test', single_end:false ]`
+  - meta2:
+      type: map
+      description: |
+        Groovy Map containing reference information
+        e.g. `[ id:'test' ]`
+  - meta3:
+      type: map
+      description: |
+        Groovy Map containing reference information
+        e.g. `[ id:'test' ]`
+  - meta4:
+      type: map
+      description: |
+        Groovy Map containing reference information
+        e.g. `[ id:'test' ]`
+  - vcf:
+      type: file
+      description: INPUT VCF file
+      pattern: "*.{vcf,vcf.gz}"
+  - idx:
+      type: file
+      description: Index of the input VCF file
+      pattern: "*.{tbi}"
+  - fasta:
+      type: file
+      description: Genome fasta file
+      pattern: "*.{fa,fasta}"
+  - fai:
+      type: file
+      description: Index of the genome fasta file
+      pattern: "*.fai"
+  - ml_model:
+      type: file
+      description: machine learning model file
+      pattern: "*.model"
+
+output:
+  - meta:
+      type: map
+      description: |
+        Groovy Map containing sample information
+        e.g. `[ id:'test', single_end:false ]`
+  - versions:
+      type: file
+      description: File containing software versions
+      pattern: "versions.yml"
+  - vcf:
+      type: file
+      description: INPUT VCF file
+      pattern: "*.{vcf,vcf.gz}"
+  - index:
+      type: file
+      description: Index of the input VCF file
+      pattern: "*.{tbi}"
+
+authors:
+  - "@ramprasadn"
diff --git a/subworkflows/local/variant_calling/call_snv_sentieon.nf b/subworkflows/local/variant_calling/call_snv_sentieon.nf
index d1b8bbb2..bbcdbc19 100644
--- a/subworkflows/local/variant_calling/call_snv_sentieon.nf
+++ b/subworkflows/local/variant_calling/call_snv_sentieon.nf
@@ -3,7 +3,7 @@
 //
 
 include { SENTIEON_DNASCOPE                        } from '../../../modules/local/sentieon/dnascope'
-include { SENTIEON_DNAMODELAPPLY                   } from '../../../modules/local/sentieon/dnamodelapply'
+include { SENTIEON_DNAMODELAPPLY                   } from '../../../modules/nf-core/sentieon/dnamodelapply/main'
 include { BCFTOOLS_MERGE                           } from '../../../modules/nf-core/bcftools/merge/main'
 include { BCFTOOLS_NORM as SPLIT_MULTIALLELICS_SEN } from '../../../modules/nf-core/bcftools/norm/main'
 include { BCFTOOLS_NORM as REMOVE_DUPLICATES_SEN   } from '../../../modules/nf-core/bcftools/norm/main'
@@ -28,7 +28,7 @@ workflow CALL_SNV_SENTIEON {
 
         SENTIEON_DNASCOPE ( ch_bam_bai, ch_genome_fasta, ch_genome_fai, ch_dbsnp, ch_dbsnp_index, ch_call_interval, ch_ml_model )
 
-        SENTIEON_DNAMODELAPPLY ( SENTIEON_DNASCOPE.out.vcf_index, ch_genome_fasta, ch_genome_fai, ch_ml_model )
+        SENTIEON_DNAMODELAPPLY ( SENTIEON_DNASCOPE.out.vcf_index, ch_genome_fasta, ch_genome_fai, [ [:], ch_ml_model ] )
 
         BCF_FILTER_ONE (SENTIEON_DNAMODELAPPLY.out.vcf )