Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Use references from CTAT #438

Open
rannick opened this issue Nov 20, 2023 · 2 comments
Open

Use references from CTAT #438

rannick opened this issue Nov 20, 2023 · 2 comments
Assignees
Milestone

Comments

@rannick
Copy link
Collaborator

rannick commented Nov 20, 2023

Description of feature

Use references from CTAT.
Allows to shorten reference building time and maybe call a few more fusions with STAR-fusion as it is optimised for this

@fevac fevac added this to the 2.4.0 milestone Dec 1, 2023
@rannick rannick self-assigned this Dec 1, 2023
@fevac
Copy link
Contributor

fevac commented Jan 11, 2024

I was wondering about this change. The clear benefit is the short reference building time but are the CTAT genomes up-to-date? I don't see many updates coming from them. Is that a problem?

@fevac
Copy link
Contributor

fevac commented Jan 16, 2024

The ensembl annotation is missing the superlocus IGH IGL so including the following in the reference gtf might improve their detection with starfusion and arriba

chr14	SuperLocus-ext	exon	105583731	106875071	.	-	.	gene_id "IGH.g@-ext"; transcript_id "IGH.t@-ext"; gene_name "IGH@-ext";
chr14	SuperLocus-ext	exon	105583731	106875071	.	+	.	gene_id "IGH-.g@-ext"; transcript_id "IGH-.t@-ext"; gene_name "IGH-@-ext";
chr22	SuperLocus-ext	exon	22030934	22923034	.	+	.	gene_id "IGL.g@-ext"; transcript_id "IGL.t@-ext"; gene_name "IGL@-ext";
chr22	SuperLocus-ext	exon	22030934	22923034	.	-	.	gene_id "IGL-.g@-ext"; transcript_id "IGL-.t@-ext"; gene_name "IGL-@-ext";

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

2 participants