diff --git a/care/facility/api/serializers/prescription.py b/care/facility/api/serializers/prescription.py
index ed68e772a7..17806c68fa 100644
--- a/care/facility/api/serializers/prescription.py
+++ b/care/facility/api/serializers/prescription.py
@@ -127,6 +127,10 @@ def validate(self, attrs):
                 raise serializers.ValidationError(
                     {"indicator": "Indicator should be set for PRN prescriptions."}
                 )
+            if attrs.get("max_dosage") and attrs.get("max_dosage") < attrs.get("base_dosage"):
+                raise serializers.ValidationError(
+                    {"max_dosage": "Max dosage cannot be less than base dosage."}
+                )
             attrs.pop("frequency", None)
             attrs.pop("days", None)
         else: