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Anemia of iron deficiency treatment with oral iron

A living systematic review

Short url: https://openmetaanalysis.github.io/anemia/

Clinical summary: This meta-analysis suggests that allternate day oral iron versus daily dosing is effective in the treatment of iron deficiency anemia with lower incidence of gastrointestinal adverse drug reactions (ADRs). Heterogeneity of results as measured by I2 was 'Moderate' at 41%. This review updates previously published meta-analysis(es).(citation[s] below)

Acknowledgement: we acknowledge the essential work by the authors of the prior systematic review(s) listed below.

Methods overview: This repository is an openMetaAnalysis that combines methods of scoping, rapid, and living systematic reviews. This analysis updates a previously published systematic review below. A comparison of studies included in this review compared to prior reviews are in the table, reconciliation of trials included with prior meta-analyses/. Newer studies included are listed in the references below. Rationale for newer trials excluded may be listed at the end of the references.

Results: Details of the studies included are in the:

The forest plot for the primary outcomes are below. Additional forest plots of secondary analyses may be available. Principle results The meta-regression for the primary outcomes are below. Additional meta-regressions of secondary analyses may be available. Principle results for benefit

References:

Systematic review(s)

Most recent review at time of last revision of this repository

  1. Kamath S, Parveen RS, Hegde S, Mathias EG, Nayak V, Boloor A. Daily versus alternate day oral iron therapy in iron deficiency anemia: a systematic review. Naunyn Schmiedebergs Arch Pharmacol. 2023 Nov 18. doi: 10.1007/s00210-023-02817-7. Epub ahead of print. PMID: 37979057.

Randomized controlled trials

New trial(s) not included in the most recent review above

  1. Jongkraijakra S, Doungngern T, Sripakdee W, Lekhakula A. A randomized controlled trial of thrice-weekly versus thrice-daily oral ferrous fumarate treatment in adult patients with iron-deficiency anemia. Ann Hematol. 2023 Jun;102(6):1333-1340. doi: 10.1007/s00277-023-05198-2. Epub 2023 Apr 3. PMID: 37010569.
  2. von Siebenthal HK, Gessler S, Vallelian F, Steinwendner J, Kuenzi UM, Moretti D, Zimmermann MB, Stoffel NU. Alternate day versus consecutive day oral iron supplementation in iron-depleted women: a randomized double-blind placebo-controlled study. EClinicalMedicine. 2023 Nov 3;65:102286. doi: 10.1016/j.eclinm.2023.102286. PMID: 38021373.

Trial(s) included in the review above

Trial(s) undergoing review

None

Trial(s) excluded - selected list of important trial(s)

Cited by

This repository is cited by:

  1. WikiDoc contributors. Pending content page. WikiDoc. Nov 9, 2014. Available at: http://www.wikidoc.org/index.php/This_topic. Accessed November 9, 2014.

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