diff --git a/.github/workflows/codeql.yml b/.github/workflows/codeql.yml
new file mode 100644
index 00000000000..757daa4bd71
--- /dev/null
+++ b/.github/workflows/codeql.yml
@@ -0,0 +1,54 @@
+name: "CodeQL"
+
+on:
+  push:
+    branches: [ "main", "wpantund/master" ]
+  pull_request:
+    branches: [ "main" ]
+  schedule:
+    - cron: "25 11 * * 2"
+
+jobs:
+  analyze:
+    name: Analyze
+    runs-on: ubuntu-latest
+    permissions:
+      actions: read
+      contents: read
+      security-events: write
+
+    strategy:
+      fail-fast: false
+      matrix:
+        language: [ javascript, cpp ]
+
+    steps:
+      - name: Checkout
+        uses: actions/checkout@v3
+        with:
+          submodules: recursive
+
+      - name: Install Packages (cpp)
+        if: ${{ matrix.language == 'cpp' }}
+        run: |
+          sudo apt-get update
+          sudo apt-get install --yes cmake libavahi-client-dev libavahi-common-dev libboost-dev libboost-filesystem-dev libboost-system-dev libcpputest-dev libdbus-1-dev libjsoncpp-dev ninja-build
+
+      - name: Initialize CodeQL
+        uses: github/codeql-action/init@v2
+        with:
+          languages: ${{ matrix.language }}
+          queries: +security-and-quality
+
+      - name: Autobuild
+        uses: github/codeql-action/autobuild@v2
+        if: ${{ matrix.language == 'javascript' }}
+
+      - name: Build cpp
+        if: ${{ matrix.language == 'cpp' }}
+        run: OTBR_OPTIONS=-DBUILD_TESTING=OFF ./script/test build
+
+      - name: Perform CodeQL Analysis
+        uses: github/codeql-action/analyze@v2
+        with:
+          category: "/language:${{ matrix.language }}"