diff --git a/cdc/kv/shared_client.go b/cdc/kv/shared_client.go
index 8138b111570..5c33f598627 100644
--- a/cdc/kv/shared_client.go
+++ b/cdc/kv/shared_client.go
@@ -96,6 +96,7 @@ var (
 	metricFeedDuplicateRequestCounter = eventFeedErrorCounter.WithLabelValues("DuplicateRequest")
 	metricFeedUnknownErrorCounter     = eventFeedErrorCounter.WithLabelValues("Unknown")
 	metricFeedRPCCtxUnavailable       = eventFeedErrorCounter.WithLabelValues("RPCCtxUnavailable")
+	metricGetStoreErr                 = eventFeedErrorCounter.WithLabelValues("GetStoreErr")
 	metricStoreSendRequestErr         = eventFeedErrorCounter.WithLabelValues("SendRequestToStore")
 	metricKvIsBusyCounter             = eventFeedErrorCounter.WithLabelValues("KvIsBusy")
 )
@@ -118,6 +119,10 @@ func (e *rpcCtxUnavailableErr) Error() string {
 		e.verID.GetID(), e.verID.GetVer(), e.verID.GetConfVer())
 }
 
+type getStoreErr struct{}
+
+func (e *getStoreErr) Error() string { return "get store error" }
+
 type sendRequestToStoreErr struct{}
 
 func (e *sendRequestToStoreErr) Error() string { return "send request to store error" }
@@ -729,6 +734,13 @@ func (s *SharedClient) doHandleError(ctx context.Context, errInfo regionErrorInf
 		metricFeedRPCCtxUnavailable.Inc()
 		s.scheduleRangeRequest(ctx, errInfo.span, errInfo.subscribedTable)
 		return nil
+	case *getStoreErr:
+		metricGetStoreErr.Inc()
+		bo := tikv.NewBackoffer(ctx, tikvRequestMaxBackoff)
+		// cannot get the store the region belongs to, so we need to reload the region.
+		s.regionCache.OnSendFail(bo, errInfo.rpcCtx, true, err)
+		s.scheduleRangeRequest(ctx, errInfo.span, errInfo.subscribedTable)
+		return nil
 	case *sendRequestToStoreErr:
 		metricStoreSendRequestErr.Inc()
 		bo := tikv.NewBackoffer(ctx, tikvRequestMaxBackoff)
diff --git a/cdc/kv/shared_client_test.go b/cdc/kv/shared_client_test.go
index 08b1488226c..c2e25532359 100644
--- a/cdc/kv/shared_client_test.go
+++ b/cdc/kv/shared_client_test.go
@@ -20,6 +20,7 @@ import (
 	"testing"
 	"time"
 
+	"github.com/pingcap/failpoint"
 	"github.com/pingcap/kvproto/pkg/cdcpb"
 	"github.com/pingcap/log"
 	"github.com/pingcap/tidb/pkg/store/mockstore/mockcopr"
@@ -261,6 +262,105 @@ func TestConnectToOfflineOrFailedTiKV(t *testing.T) {
 	}
 }
 
+func TestGetStoreFailed(t *testing.T) {
+	ctx, cancel := context.WithCancel(context.Background())
+	wg := &sync.WaitGroup{}
+
+	events1 := make(chan *cdcpb.ChangeDataEvent, 10)
+	srv1 := newMockChangeDataServer(events1)
+	server1, addr1 := newMockService(ctx, t, srv1, wg)
+
+	rpcClient, cluster, pdClient, _ := testutils.NewMockTiKV("", mockcopr.NewCoprRPCHandler())
+
+	pdClient = &mockPDClient{Client: pdClient, versionGen: defaultVersionGen}
+
+	grpcPool := sharedconn.NewConnAndClientPool(&security.Credential{}, nil)
+
+	regionCache := tikv.NewRegionCache(pdClient)
+
+	pdClock := pdutil.NewClock4Test()
+
+	kvStorage, err := tikv.NewTestTiKVStore(rpcClient, pdClient, nil, nil, 0)
+	require.Nil(t, err)
+	lockResolver := txnutil.NewLockerResolver(kvStorage, model.ChangeFeedID{})
+
+	invalidStore1 := "localhost:1"
+	invalidStore2 := "localhost:2"
+	cluster.AddStore(1, addr1)
+	cluster.AddStore(2, invalidStore1)
+	cluster.AddStore(3, invalidStore2)
+	cluster.Bootstrap(11, []uint64{1, 2, 3}, []uint64{4, 5, 6}, 4)
+
+	client := NewSharedClient(
+		model.ChangeFeedID{ID: "test"},
+		&config.ServerConfig{
+			KVClient: &config.KVClientConfig{
+				WorkerConcurrent:     1,
+				GrpcStreamConcurrent: 1,
+				AdvanceIntervalInMs:  10,
+			},
+			Debug: &config.DebugConfig{Puller: &config.PullerConfig{LogRegionDetails: false}},
+		},
+		false, pdClient, grpcPool, regionCache, pdClock, lockResolver,
+	)
+
+	defer func() {
+		cancel()
+		client.Close()
+		_ = kvStorage.Close()
+		regionCache.Close()
+		pdClient.Close()
+		srv1.wg.Wait()
+		server1.Stop()
+		wg.Wait()
+	}()
+
+	wg.Add(1)
+	go func() {
+		defer wg.Done()
+		err := client.Run(ctx)
+		require.Equal(t, context.Canceled, errors.Cause(err))
+	}()
+
+	failpoint.Enable("github.com/pingcap/tiflow/pkg/version/GetStoreFailed", `return(true)`)
+	subID := client.AllocSubscriptionID()
+	span := tablepb.Span{TableID: 1, StartKey: []byte("a"), EndKey: []byte("b")}
+	eventCh := make(chan MultiplexingEvent, 50)
+	client.Subscribe(subID, span, 1, eventCh)
+
+	makeTsEvent := func(regionID, ts, requestID uint64) *cdcpb.ChangeDataEvent {
+		return &cdcpb.ChangeDataEvent{
+			Events: []*cdcpb.Event{
+				{
+					RegionId:  regionID,
+					RequestId: requestID,
+					Event:     &cdcpb.Event_ResolvedTs{ResolvedTs: ts},
+				},
+			},
+		}
+	}
+
+	checkTsEvent := func(event model.RegionFeedEvent, ts uint64) {
+		require.Equal(t, ts, event.Resolved.ResolvedTs)
+	}
+
+	events1 <- mockInitializedEvent(11, uint64(subID))
+	ts := oracle.GoTimeToTS(pdClock.CurrentTime())
+	events1 <- makeTsEvent(11, ts, uint64(subID))
+	select {
+	case <-eventCh:
+		require.True(t, false, "should not get event when get store failed")
+	case <-time.After(5 * time.Second):
+	}
+	failpoint.Disable("github.com/pingcap/tiflow/pkg/version/GetStoreFailed")
+	select {
+	case event := <-eventCh:
+		checkTsEvent(event.RegionFeedEvent, ts)
+	case <-time.After(5 * time.Second):
+		require.True(t, false, "reconnection not succeed in 5 second")
+	}
+}
+
 type mockChangeDataServer struct {
 	ch chan *cdcpb.ChangeDataEvent
 	wg sync.WaitGroup
diff --git a/cdc/kv/shared_stream.go b/cdc/kv/shared_stream.go
index 1427d80daf6..552a642e151 100644
--- a/cdc/kv/shared_stream.go
+++ b/cdc/kv/shared_stream.go
@@ -23,6 +23,7 @@ import (
 	"github.com/pingcap/log"
 	"github.com/pingcap/tiflow/cdc/kv/sharedconn"
 	"github.com/pingcap/tiflow/pkg/chann"
+	cerrors "github.com/pingcap/tiflow/pkg/errors"
 	"github.com/pingcap/tiflow/pkg/util"
 	"github.com/pingcap/tiflow/pkg/version"
 	"go.uber.org/zap"
@@ -90,12 +91,31 @@ func newStream(ctx context.Context, c *SharedClient, g *errgroup.Group, r *reque
 			if err := waitForPreFetching(); err != nil {
 				return err
 			}
-			if canceled := stream.run(ctx, c, r); canceled {
-				return nil
+			var regionErr error
+			if err := version.CheckStoreVersion(ctx, c.pd, r.storeID); err != nil {
+				log.Info("event feed check store version fails",
+					zap.String("namespace", c.changefeed.Namespace),
+					zap.String("changefeed", c.changefeed.ID),
+					zap.Uint64("streamID", stream.streamID),
+					zap.Uint64("storeID", r.storeID),
+					zap.String("addr", r.storeAddr),
+					zap.Error(err))
+				if errors.Cause(err) == context.Canceled {
+					return nil
+				} else if cerrors.Is(err, cerrors.ErrGetAllStoresFailed) {
+					regionErr = &getStoreErr{}
+				} else {
+					regionErr = &sendRequestToStoreErr{}
+				}
+			} else {
+				if canceled := stream.run(ctx, c, r); canceled {
+					return nil
+				}
+				regionErr = &sendRequestToStoreErr{}
 			}
 			for _, m := range stream.clearStates() {
 				for _, state := range m {
-					state.markStopped(&sendRequestToStoreErr{})
+					state.markStopped(regionErr)
 					sfEvent := newEventItem(nil, state, stream)
 					slot := hashRegionID(state.region.verID.GetID(), len(c.workers))
 					_ = c.workers[slot].sendEvent(ctx, sfEvent)
@@ -108,7 +128,7 @@ func newStream(ctx context.Context, c *SharedClient, g *errgroup.Group, r *reque
 					// It means it's a special task for stopping the table.
 					continue
 				}
-				c.onRegionFail(newRegionErrorInfo(region, &sendRequestToStoreErr{}))
+				c.onRegionFail(newRegionErrorInfo(region, regionErr))
 			}
 			if err := util.Hang(ctx, time.Second); err != nil {
 				return err
@@ -135,17 +155,6 @@ func (s *requestedStream) run(ctx context.Context, c *SharedClient, rs *requeste
 		}
 	}
 
-	if err := version.CheckStoreVersion(ctx, c.pd, rs.storeID); err != nil {
-		log.Info("event feed check store version fails",
-			zap.String("namespace", c.changefeed.Namespace),
-			zap.String("changefeed", c.changefeed.ID),
-			zap.Uint64("streamID", s.streamID),
-			zap.Uint64("storeID", rs.storeID),
-			zap.String("addr", rs.storeAddr),
-			zap.Error(err))
-		return isCanceled()
-	}
-
 	log.Info("event feed going to create grpc stream",
 		zap.String("namespace", c.changefeed.Namespace),
 		zap.String("changefeed", c.changefeed.ID),
@@ -342,7 +351,9 @@ func (s *requestedStream) send(ctx context.Context, c *SharedClient, rs *request
 			if s.multiplexing != nil {
 				req := &cdcpb.ChangeDataRequest{
 					RequestId: uint64(subscriptionID),
-					Request:   &cdcpb.ChangeDataRequest_Deregister_{},
+					Request: &cdcpb.ChangeDataRequest_Deregister_{
+						Deregister: &cdcpb.ChangeDataRequest_Deregister{},
+					},
 				}
 				if err = doSend(s.multiplexing, req, subscriptionID); err != nil {
 					return err
diff --git a/pkg/version/check.go b/pkg/version/check.go
index 9237eab4154..6044d1adaf1 100644
--- a/pkg/version/check.go
+++ b/pkg/version/check.go
@@ -24,6 +24,7 @@ import (
 
 	"github.com/coreos/go-semver/semver"
 	"github.com/pingcap/errors"
+	"github.com/pingcap/failpoint"
 	"github.com/pingcap/kvproto/pkg/metapb"
 	"github.com/pingcap/log"
 	"github.com/pingcap/tidb/pkg/util/engine"
@@ -197,6 +198,9 @@ func checkPDVersion(ctx context.Context, pdAddr string, credential *security.Cre
 // CheckStoreVersion checks whether the given TiKV is compatible with this CDC.
 // If storeID is 0, it checks all TiKV.
 func CheckStoreVersion(ctx context.Context, client pd.Client, storeID uint64) error {
+	failpoint.Inject("GetStoreFailed", func() {
+		failpoint.Return(cerror.WrapError(cerror.ErrGetAllStoresFailed, fmt.Errorf("unknown store %d", storeID)))
+	})
 	var stores []*metapb.Store
 	var err error
 	if storeID == 0 {