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Add Epolactaene tertiary butyl ester drug target
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Refs #2304
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kimrutherford committed Dec 14, 2024
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Expand Up @@ -39,6 +39,7 @@ dehydroxestoquinone | [myo2](/gene/SPCC645.05c), [myp2](/gene/SPAC4A8.05c) | my
[dihydromotuporamine C](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:82642) | | proteasome? | lipid synthesis? | |
[diuron](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:116509) | | inhibits [mitochondrial complex III](/term/GO:0005750) | [respiratory electron transport](/term/GO:0022904) | | [PMID:33400299](/reference/PMID:33400299) |
[enfumafungin](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:61749) | [bgs4](/gene/SPCC1840.02c) | 1,6 branched 1,3-beta-glucan synthase | [cell wall synthesis](/term/GO:0009272) | Bgs1 and Bgs3 are unaffected | [PMID:21115488](/reference/PMID:21115488)
[Epolactaene tertiary butyl ester (ETB)](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:219837)| [mcp60](/gene/SPAC12G12.04) | chaperone activity | [mitochondrial transcription](/term/GO:0006390), probably others | | [PMID:15603555](/reference/PMID:15603555), [PMID:23035257](/reference/PMID:23035257)
[fenpropimorph](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50145) | | proteasome? | lipid synthesis? | |
[hydroxyurea](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:44423) | [suc22](/gene/SPBC25D12.04) | ribonucleotide reductase small subunit | slows DNA synthesis | causes replication fork stalling | [PMID:27869662](https://pubmed.ncbi.nlm.nih.gov/27869662/) (PubMed link)
[hygromycin B](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16976) | | 40S ribosomal subunit | [translation](/term/GO:0002181) | interferes with translocation of tRNA from the A site to the P site of the ribosome |
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