From 6fe43f609e3a9464aeb805524f2348a61a0f40d5 Mon Sep 17 00:00:00 2001 From: Kim Rutherford Date: Sat, 14 Dec 2024 22:19:14 +1300 Subject: [PATCH] Add Epolactaene tertiary butyl ester drug target Refs pombase/website#2304 --- src/docs/browse-curation/drugs-known-pombe-targets.PomBase.md | 1 + 1 file changed, 1 insertion(+) diff --git a/src/docs/browse-curation/drugs-known-pombe-targets.PomBase.md b/src/docs/browse-curation/drugs-known-pombe-targets.PomBase.md index 96134768..3e32668a 100644 --- a/src/docs/browse-curation/drugs-known-pombe-targets.PomBase.md +++ b/src/docs/browse-curation/drugs-known-pombe-targets.PomBase.md @@ -39,6 +39,7 @@ dehydroxestoquinone | [myo2](/gene/SPCC645.05c), [myp2](/gene/SPAC4A8.05c) | my [dihydromotuporamine C](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:82642) | | proteasome? | lipid synthesis? | | [diuron](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:116509) | | inhibits [mitochondrial complex III](/term/GO:0005750) | [respiratory electron transport](/term/GO:0022904) | | [PMID:33400299](/reference/PMID:33400299) | [enfumafungin](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:61749) | [bgs4](/gene/SPCC1840.02c) | 1,6 branched 1,3-beta-glucan synthase | [cell wall synthesis](/term/GO:0009272) | Bgs1 and Bgs3 are unaffected | [PMID:21115488](/reference/PMID:21115488) +[Epolactaene tertiary butyl ester (ETB)](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:219837)| [mcp60](/gene/SPAC12G12.04) | chaperone activity | [mitochondrial transcription](/term/GO:0006390), probably others | | [PMID:15603555](/reference/PMID:15603555), [PMID:23035257](/reference/PMID:23035257) [fenpropimorph](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50145) | | proteasome? | lipid synthesis? | | [hydroxyurea](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:44423) | [suc22](/gene/SPBC25D12.04) | ribonucleotide reductase small subunit | slows DNA synthesis | causes replication fork stalling | [PMID:27869662](https://pubmed.ncbi.nlm.nih.gov/27869662/) (PubMed link) [hygromycin B](https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16976) | | 40S ribosomal subunit | [translation](/term/GO:0002181) | interferes with translocation of tRNA from the A site to the P site of the ribosome |