diff --git a/frontend/src/__tests__/cypress/cypress/tests/mocked/modelRegistrySettings/modelRegistrySettings.cy.ts b/frontend/src/__tests__/cypress/cypress/tests/mocked/modelRegistrySettings/modelRegistrySettings.cy.ts
index e28c313a8b..c53db78230 100644
--- a/frontend/src/__tests__/cypress/cypress/tests/mocked/modelRegistrySettings/modelRegistrySettings.cy.ts
+++ b/frontend/src/__tests__/cypress/cypress/tests/mocked/modelRegistrySettings/modelRegistrySettings.cy.ts
@@ -12,6 +12,16 @@ import {
   asProjectAdminUser,
 } from '~/__tests__/cypress/cypress/utils/mockUsers';
 import { mockModelRegistry } from '~/__mocks__/mockModelRegistry';
+import type { RoleBindingSubject } from '~/k8sTypes';
+import { mockRoleBindingK8sResource } from '~/__mocks__/mockRoleBindingK8sResource';
+
+const groupSubjects: RoleBindingSubject[] = [
+  {
+    kind: 'Group',
+    apiGroup: 'rbac.authorization.k8s.io',
+    name: 'example-mr-users',
+  },
+];
 
 const setupMocksForMRSettingAccess = ({
   hasModelRegistries = true,
@@ -71,6 +81,19 @@ const setupMocksForMRSettingAccess = ({
       req.reply(500); // Something went wrong on the backend when decoding the secret
     },
   );
+
+  cy.interceptOdh(
+    'GET /api/modelRegistryRoleBindings',
+    mockK8sResourceList([
+      mockRoleBindingK8sResource({
+        namespace: 'odh-model-registries',
+        name: 'example-mr-user',
+        subjects: groupSubjects,
+        roleRefName: 'registry-user-example-mr',
+        modelRegistryName: 'example-mr',
+      }),
+    ]),
+  );
 };
 
 it('Model registry settings should not be available for non product admins', () => {
diff --git a/frontend/src/pages/modelRegistrySettings/ModelRegistriesTable.tsx b/frontend/src/pages/modelRegistrySettings/ModelRegistriesTable.tsx
index 011e7a67f4..3afdb311d7 100644
--- a/frontend/src/pages/modelRegistrySettings/ModelRegistriesTable.tsx
+++ b/frontend/src/pages/modelRegistrySettings/ModelRegistriesTable.tsx
@@ -1,18 +1,21 @@
 import React from 'react';
 import { Button, Toolbar, ToolbarContent, ToolbarItem } from '@patternfly/react-core';
 import { Table } from '~/components/table';
-import { ModelRegistryKind } from '~/k8sTypes';
+import { ModelRegistryKind, RoleBindingKind } from '~/k8sTypes';
+import { ContextResourceData } from '~/types';
 import { modelRegistryColumns } from './columns';
 import ModelRegistriesTableRow from './ModelRegistriesTableRow';
 
 type ModelRegistriesTableProps = {
   modelRegistries: ModelRegistryKind[];
   refresh: () => Promise<unknown>;
+  roleBindings: ContextResourceData<RoleBindingKind>;
   onCreateModelRegistryClick: () => void;
 };
 
 const ModelRegistriesTable: React.FC<ModelRegistriesTableProps> = ({
   modelRegistries,
+  roleBindings,
   refresh,
   onCreateModelRegistryClick,
 }) => (
@@ -36,7 +39,12 @@ const ModelRegistriesTable: React.FC<ModelRegistriesTableProps> = ({
       </Toolbar>
     }
     rowRenderer={(mr) => (
-      <ModelRegistriesTableRow key={mr.metadata.name} modelRegistry={mr} refresh={refresh} />
+      <ModelRegistriesTableRow
+        key={mr.metadata.name}
+        modelRegistry={mr}
+        roleBindings={roleBindings}
+        refresh={refresh}
+      />
     )}
     variant="compact"
   />
diff --git a/frontend/src/pages/modelRegistrySettings/ModelRegistriesTableRow.tsx b/frontend/src/pages/modelRegistrySettings/ModelRegistriesTableRow.tsx
index cd75a344f5..88376c2f8c 100644
--- a/frontend/src/pages/modelRegistrySettings/ModelRegistriesTableRow.tsx
+++ b/frontend/src/pages/modelRegistrySettings/ModelRegistriesTableRow.tsx
@@ -1,23 +1,33 @@
 import React from 'react';
 import { ActionsColumn, Td, Tr } from '@patternfly/react-table';
 import { Link } from 'react-router-dom';
-import { ModelRegistryKind } from '~/k8sTypes';
+import { Tooltip } from '@patternfly/react-core';
+import { ModelRegistryKind, RoleBindingKind } from '~/k8sTypes';
 import ResourceNameTooltip from '~/components/ResourceNameTooltip';
+import { ContextResourceData } from '~/types';
 import ViewDatabaseConfigModal from './ViewDatabaseConfigModal';
 import DeleteModelRegistryModal from './DeleteModelRegistryModal';
 import { ModelRegistryTableRowStatus } from './ModelRegistryTableRowStatus';
 
 type ModelRegistriesTableRowProps = {
   modelRegistry: ModelRegistryKind;
+  roleBindings: ContextResourceData<RoleBindingKind>;
   refresh: () => Promise<unknown>;
 };
 
 const ModelRegistriesTableRow: React.FC<ModelRegistriesTableRowProps> = ({
   modelRegistry: mr,
+  roleBindings,
   refresh,
 }) => {
   const [isDatabaseConfigModalOpen, setIsDatabaseConfigModalOpen] = React.useState(false);
   const [isDeleteModalOpen, setIsDeleteModalOpen] = React.useState(false);
+  const filteredRoleBindings = roleBindings.data.filter(
+    (rb) =>
+      rb.metadata.labels?.['app.kubernetes.io/name'] ===
+      (mr.metadata.name || mr.metadata.annotations?.['openshift.io/display-name']),
+  );
+
   return (
     <>
       <Tr>
@@ -35,12 +45,18 @@ const ModelRegistriesTableRow: React.FC<ModelRegistriesTableRowProps> = ({
           <ModelRegistryTableRowStatus conditions={mr.status?.conditions} />
         </Td>
         <Td modifier="fitContent">
-          <Link
-            aria-label={`Manage permissions for model registry ${mr.metadata.name}`}
-            to={`/modelRegistrySettings/permissions/${mr.metadata.name}`}
-          >
-            Manage permissions
-          </Link>
+          {filteredRoleBindings.length === 0 ? (
+            <Tooltip content="You can manage permissions when the model registry becomes available.">
+              <span className="pf-v5-u-disabled-color-100">Manage permissions</span>
+            </Tooltip>
+          ) : (
+            <Link
+              aria-label={`Manage permissions for model registry ${mr.metadata.name}`}
+              to={`/modelRegistrySettings/permissions/${mr.metadata.name}`}
+            >
+              Manage permissions
+            </Link>
+          )}
         </Td>
         <Td isActionCell>
           <ActionsColumn
diff --git a/frontend/src/pages/modelRegistrySettings/ModelRegistrySettings.tsx b/frontend/src/pages/modelRegistrySettings/ModelRegistrySettings.tsx
index 2417210a08..1784acf791 100644
--- a/frontend/src/pages/modelRegistrySettings/ModelRegistrySettings.tsx
+++ b/frontend/src/pages/modelRegistrySettings/ModelRegistrySettings.tsx
@@ -15,13 +15,19 @@ import useModelRegistriesBackend from '~/concepts/modelRegistrySettings/useModel
 import TitleWithIcon from '~/concepts/design/TitleWithIcon';
 import { ProjectObjectType } from '~/concepts/design/utils';
 import { ModelRegistrySelectorContext } from '~/concepts/modelRegistry/context/ModelRegistrySelectorContext';
+import { useContextResourceData } from '~/utilities/useContextResourceData';
+import { RoleBindingKind } from '~/k8sTypes';
 import ModelRegistriesTable from './ModelRegistriesTable';
 import CreateModal from './CreateModal';
+import useModelRegistryRoleBindings from './useModelRegistryRoleBindings';
 
 const ModelRegistrySettings: React.FC = () => {
   const [createModalOpen, setCreateModalOpen] = React.useState(false);
-  const [modelRegistries, loaded, loadError, refreshModelRegistries] = useModelRegistriesBackend();
+  const [modelRegistries, mrloaded, loadError, refreshModelRegistries] =
+    useModelRegistriesBackend();
+  const roleBindings = useContextResourceData<RoleBindingKind>(useModelRegistryRoleBindings());
   const { refreshRulesReview } = React.useContext(ModelRegistrySelectorContext);
+  const loaded = mrloaded && roleBindings.loaded;
 
   const refreshAll = React.useCallback(
     () => Promise.all([refreshModelRegistries(), refreshRulesReview()]),
@@ -65,6 +71,7 @@ const ModelRegistrySettings: React.FC = () => {
       >
         <ModelRegistriesTable
           modelRegistries={modelRegistries}
+          roleBindings={roleBindings}
           refresh={refreshAll}
           onCreateModelRegistryClick={() => {
             setCreateModalOpen(true);