diff --git a/src/_cffi_src/openssl/err.py b/src/_cffi_src/openssl/err.py
index 2c7469ff892c..a86e560a659c 100644
--- a/src/_cffi_src/openssl/err.py
+++ b/src/_cffi_src/openssl/err.py
@@ -13,7 +13,6 @@
 static const int EVP_R_DATA_NOT_MULTIPLE_OF_BLOCK_LENGTH;
 
 static const int ERR_LIB_EVP;
-static const int ERR_LIB_PROV;
 
 static const int SSL_TLSEXT_ERR_OK;
 static const int SSL_TLSEXT_ERR_ALERT_FATAL;
@@ -37,12 +36,6 @@
 """
 
 CUSTOMIZATIONS = """
-/* This define is tied to provider support and is conditionally
-   removed if Cryptography_HAS_PROVIDERS is false */
-#ifndef ERR_LIB_PROV
-#define ERR_LIB_PROV 0
-#endif
-
 #if CRYPTOGRAPHY_IS_BORINGSSL
 static const int EVP_F_EVP_ENCRYPTFINAL_EX = 0;
 static const int EVP_R_DATA_NOT_MULTIPLE_OF_BLOCK_LENGTH = 0;
diff --git a/src/_cffi_src/openssl/evp.py b/src/_cffi_src/openssl/evp.py
index 7432bc046bb5..59e002bad682 100644
--- a/src/_cffi_src/openssl/evp.py
+++ b/src/_cffi_src/openssl/evp.py
@@ -22,8 +22,6 @@
 static const int EVP_PKEY_EC;
 static const int EVP_PKEY_X25519;
 static const int EVP_PKEY_ED25519;
-static const int EVP_PKEY_X448;
-static const int EVP_PKEY_ED448;
 static const int EVP_MAX_MD_SIZE;
 
 static const int Cryptography_HAS_EVP_PKEY_DHX;
@@ -73,19 +71,6 @@
 const long Cryptography_HAS_EVP_PKEY_DHX = 0;
 #endif
 
-/* This is tied to X448 support so we reuse the Cryptography_HAS_X448
-   conditional to remove it. OpenSSL 1.1.1 adds this define.  We can remove
-   this in the distant future when we drop 1.1.0 support. */
-#ifndef EVP_PKEY_X448
-#define EVP_PKEY_X448 NID_X448
-#endif
-
-/* This is tied to ED448 support so we reuse the Cryptography_HAS_ED448
-   conditional to remove it. */
-#ifndef EVP_PKEY_ED448
-#define EVP_PKEY_ED448 0
-#endif
-
 #if CRYPTOGRAPHY_OPENSSL_300_OR_GREATER
 static const long Cryptography_HAS_300_FIPS = 1;
 #else
diff --git a/src/_cffi_src/openssl/provider.py b/src/_cffi_src/openssl/provider.py
index a9fb92f17d13..f00b28325164 100644
--- a/src/_cffi_src/openssl/provider.py
+++ b/src/_cffi_src/openssl/provider.py
@@ -16,8 +16,6 @@
 
 typedef ... OSSL_PROVIDER;
 typedef ... OSSL_LIB_CTX;
-
-static const long PROV_R_BAD_DECRYPT;
 """
 
 FUNCTIONS = """
@@ -32,7 +30,6 @@
 static const long Cryptography_HAS_PROVIDERS = 0;
 typedef void OSSL_PROVIDER;
 typedef void OSSL_LIB_CTX;
-static const long PROV_R_BAD_DECRYPT = 0;
 OSSL_PROVIDER *(*OSSL_PROVIDER_load)(OSSL_LIB_CTX *, const char *) = NULL;
 int (*OSSL_PROVIDER_unload)(OSSL_PROVIDER *) = NULL;
 #endif
diff --git a/src/cryptography/hazmat/bindings/openssl/_conditional.py b/src/cryptography/hazmat/bindings/openssl/_conditional.py
index 5a559c3b9ab5..8def8bf487b9 100644
--- a/src/cryptography/hazmat/bindings/openssl/_conditional.py
+++ b/src/cryptography/hazmat/bindings/openssl/_conditional.py
@@ -28,12 +28,6 @@ def cryptography_has_tls_st() -> list[str]:
     ]
 
 
-def cryptography_has_ed448() -> list[str]:
-    return [
-        "EVP_PKEY_ED448",
-    ]
-
-
 def cryptography_has_ssl_sigalgs() -> list[str]:
     return [
         "SSL_CTX_set1_sigalgs_list",
@@ -119,8 +113,6 @@ def cryptography_has_providers() -> list[str]:
     return [
         "OSSL_PROVIDER_load",
         "OSSL_PROVIDER_unload",
-        "ERR_LIB_PROV",
-        "PROV_R_BAD_DECRYPT",
     ]
 
 
@@ -191,7 +183,6 @@ def cryptography_has_get_extms_support() -> list[str]:
     "Cryptography_HAS_SET_CERT_CB": cryptography_has_set_cert_cb,
     "Cryptography_HAS_SSL_ST": cryptography_has_ssl_st,
     "Cryptography_HAS_TLS_ST": cryptography_has_tls_st,
-    "Cryptography_HAS_ED448": cryptography_has_ed448,
     "Cryptography_HAS_SIGALGS": cryptography_has_ssl_sigalgs,
     "Cryptography_HAS_PSK": cryptography_has_psk,
     "Cryptography_HAS_PSK_TLSv1_3": cryptography_has_psk_tlsv13,