diff --git a/compiler/src/dotty/tools/dotc/typer/Nullables.scala b/compiler/src/dotty/tools/dotc/typer/Nullables.scala
index 3f071dad2d03..62d2ccfb7200 100644
--- a/compiler/src/dotty/tools/dotc/typer/Nullables.scala
+++ b/compiler/src/dotty/tools/dotc/typer/Nullables.scala
@@ -52,12 +52,10 @@ object Nullables:
     val hiTree = if(hiTpe eq hi.typeOpt) hi else TypeTree(hiTpe)
     TypeBoundsTree(lo, hiTree, alias)
 
-  /** A set of val or var references that are known to be not null, plus a set of
-   *  variable references that are not known (anymore) to be not null
+  /** A set of val or var references that are known to be not null,
+   *  plus a set of variable references that are once assigned to null.
    */
   case class NotNullInfo(asserted: Set[TermRef], retracted: Set[TermRef]):
-    assert((asserted & retracted).isEmpty)
-
     def isEmpty = this eq NotNullInfo.empty
 
     def retractedInfo = NotNullInfo(Set(), retracted)
@@ -67,8 +65,8 @@ object Nullables:
       if this.isEmpty then that
       else if that.isEmpty then this
       else NotNullInfo(
-        this.asserted.union(that.asserted).diff(that.retracted),
-        this.retracted.union(that.retracted).diff(that.asserted))
+        this.asserted.diff(that.retracted).union(that.asserted),
+        this.retracted.union(that.retracted))
 
     /** The alternative path combination with another not-null info. Used to merge
      *  the nullability info of the two branches of an if.
@@ -76,6 +74,9 @@ object Nullables:
     def alt(that: NotNullInfo): NotNullInfo =
       NotNullInfo(this.asserted.intersect(that.asserted), this.retracted.union(that.retracted))
 
+    def withRetracted(that: NotNullInfo): NotNullInfo =
+      NotNullInfo(this.asserted, this.retracted.union(that.retracted))
+
   object NotNullInfo:
     val empty = new NotNullInfo(Set(), Set())
     def apply(asserted: Set[TermRef], retracted: Set[TermRef]): NotNullInfo =
@@ -233,16 +234,13 @@ object Nullables:
     *  or retractions in `info` supersede infos in existing entries of `infos`.
     */
     def extendWith(info: NotNullInfo) =
-      if info.isEmpty
-        || info.asserted.forall(infos.impliesNotNull(_))
-            && !info.retracted.exists(infos.impliesNotNull(_))
-      then infos
+      if info.isEmpty then infos
       else info :: infos
 
     /** Retract all references to mutable variables */
     def retractMutables(using Context) =
-      val mutables = infos.foldLeft(Set[TermRef]())((ms, info) =>
-        ms.union(info.asserted.filter(_.symbol.is(Mutable))))
+      val mutables = infos.foldLeft(Set[TermRef]()):
+        (ms, info) => ms.union(info.asserted.filter(_.symbol.is(Mutable)))
       infos.extendWith(NotNullInfo(Set(), mutables))
 
   end extension
diff --git a/compiler/src/dotty/tools/dotc/typer/Typer.scala b/compiler/src/dotty/tools/dotc/typer/Typer.scala
index 901e27a2f1a1..b1e087af6d48 100644
--- a/compiler/src/dotty/tools/dotc/typer/Typer.scala
+++ b/compiler/src/dotty/tools/dotc/typer/Typer.scala
@@ -1543,8 +1543,10 @@ class Typer(@constructorOnly nestingLevel: Int = 0) extends Namer
     def thenPathInfo = cond1.notNullInfoIf(true).seq(result.thenp.notNullInfo)
     def elsePathInfo = cond1.notNullInfoIf(false).seq(result.elsep.notNullInfo)
     result.withNotNullInfo(
-      if result.thenp.tpe.isRef(defn.NothingClass) then elsePathInfo
-      else if result.elsep.tpe.isRef(defn.NothingClass) then thenPathInfo
+      if result.thenp.tpe.isRef(defn.NothingClass) then
+        elsePathInfo.withRetracted(thenPathInfo)
+      else if result.elsep.tpe.isRef(defn.NothingClass) then
+        thenPathInfo.withRetracted(elsePathInfo)
       else thenPathInfo.alt(elsePathInfo)
     )
   end typedIf
@@ -2151,9 +2153,9 @@ class Typer(@constructorOnly nestingLevel: Int = 0) extends Namer
   def typedMatchFinish(tree: untpd.Match, sel: Tree, wideSelType: Type, cases: List[untpd.CaseDef], pt: Type)(using Context): Tree = {
     val cases1 = harmonic(harmonize, pt)(typedCases(cases, sel, wideSelType, pt.dropIfProto))
       .asInstanceOf[List[CaseDef]]
-    var nni = sel.notNullInfo
-    if cases1.nonEmpty then nni = nni.seq(cases1.map(_.notNullInfo).reduce(_.alt(_)))
-    assignType(cpy.Match(tree)(sel, cases1), sel, cases1).withNotNullInfo(nni)
+    var nnInfo = sel.notNullInfo
+    if cases1.nonEmpty then nnInfo = nnInfo.seq(cases1.map(_.notNullInfo).reduce(_.alt(_)))
+    assignType(cpy.Match(tree)(sel, cases1), sel, cases1).withNotNullInfo(nnInfo)
   }
 
   def typedCases(cases: List[untpd.CaseDef], sel: Tree, wideSelType0: Type, pt: Type)(using Context): List[CaseDef] =
@@ -2335,7 +2337,8 @@ class Typer(@constructorOnly nestingLevel: Int = 0) extends Namer
       val capabilityProof = caughtExceptions.reduce(OrType(_, _, true))
       untpd.Block(makeCanThrow(capabilityProof), expr)
 
-  def typedTry(tree: untpd.Try, pt: Type)(using Context): Try = {
+  def typedTry(tree: untpd.Try, pt: Type)(using Context): Try =
+    var nnInfo = NotNullInfo.empty
     val expr2 :: cases2x = harmonic(harmonize, pt) {
       // We want to type check tree.expr first to comput NotNullInfo, but `addCanThrowCapabilities`
       // uses the types of patterns in `tree.cases` to determine the capabilities.
@@ -2347,18 +2350,26 @@ class Typer(@constructorOnly nestingLevel: Int = 0) extends Namer
       val casesEmptyBody1 = tree.cases.mapconserve(cpy.CaseDef(_)(body = EmptyTree))
       val casesEmptyBody2 = typedCases(casesEmptyBody1, EmptyTree, defn.ThrowableType, WildcardType)
       val expr1 = typed(addCanThrowCapabilities(tree.expr, casesEmptyBody2), pt.dropIfProto)
-      val casesCtx = ctx.addNotNullInfo(expr1.notNullInfo.retractedInfo)
+
+      // Since we don't know at which point the the exception is thrown in the body,
+      // we have to collect any reference that is once retracted.
+      nnInfo = expr1.notNullInfo.retractedInfo
+
+      val casesCtx = ctx.addNotNullInfo(nnInfo)
       val cases1 = typedCases(tree.cases, EmptyTree, defn.ThrowableType, pt.dropIfProto)(using casesCtx)
       expr1 :: cases1
     }: @unchecked
     val cases2 = cases2x.asInstanceOf[List[CaseDef]]
 
-    var nni = expr2.notNullInfo.retractedInfo
-    if cases2.nonEmpty then nni = nni.seq(cases2.map(_.notNullInfo.retractedInfo).reduce(_.alt(_)))
-    val finalizer1 = typed(tree.finalizer, defn.UnitType)(using ctx.addNotNullInfo(nni))
-    nni = nni.seq(finalizer1.notNullInfo)
-    assignType(cpy.Try(tree)(expr2, cases2, finalizer1), expr2, cases2).withNotNullInfo(nni)
-  }
+    // It is possible to have non-exhaustive cases, and some exceptions are thrown and not caught.
+    // Therefore, the code in the finallizer and after the try block can only rely on the retracted
+    // info from the cases' body.
+    if cases2.nonEmpty then
+      nnInfo = nnInfo.seq(cases2.map(_.notNullInfo.retractedInfo).reduce(_.alt(_)))
+
+    val finalizer1 = typed(tree.finalizer, defn.UnitType)(using ctx.addNotNullInfo(nnInfo))
+    nnInfo = nnInfo.seq(finalizer1.notNullInfo)
+    assignType(cpy.Try(tree)(expr2, cases2, finalizer1), expr2, cases2).withNotNullInfo(nnInfo)
 
   def typedTry(tree: untpd.ParsedTry, pt: Type)(using Context): Try =
     val cases: List[untpd.CaseDef] = tree.handler match
diff --git a/tests/explicit-nulls/neg/i21380c.scala b/tests/explicit-nulls/neg/i21380c.scala
index f86a5638e4c8..de3cd5bafd6b 100644
--- a/tests/explicit-nulls/neg/i21380c.scala
+++ b/tests/explicit-nulls/neg/i21380c.scala
@@ -32,9 +32,9 @@ def test4: Int =
     case npe: NullPointerException => x = ""
     case _ => x = ""
   x.length // error
-  // Although the catch block here is exhaustive,
-  // it is possible that the exception is thrown and not caught.
-  // Therefore, the code after the try block can only rely on the retracted info.
+  // Although the catch block here is exhaustive, it is possible to have non-exhaustive cases,
+  // and some exceptions are thrown and not caught. Therefore, the code in the finallizer and
+  // after the try block can only rely on the retracted info from the cases' body.
 
 def test5: Int =
   var x: String | Null = null
diff --git a/tests/explicit-nulls/neg/i21619.scala b/tests/explicit-nulls/neg/i21619.scala
new file mode 100644
index 000000000000..244f993fd4e1
--- /dev/null
+++ b/tests/explicit-nulls/neg/i21619.scala
@@ -0,0 +1,79 @@
+def test1: String =
+  var x: String | Null = null
+  x = ""
+  var i: Int = 1
+  try
+    i match
+      case _ =>
+        x = null
+        throw new Exception()
+    x = ""
+  catch
+    case e: Exception =>
+  x.replace("", "") // error
+
+def test2: String =
+  var x: String | Null = null
+  x = ""
+  var i: Int = 1
+  try
+    i match
+      case _ =>
+        x = null
+        throw new Exception()
+    x = ""
+  catch
+    case e: Exception =>
+      x = "e"
+  x.replace("", "") // error
+
+def test3: String =
+  var x: String | Null = null
+  x = ""
+  var i: Int = 1
+  try
+    i match
+      case _ =>
+        x = null
+        throw new Exception()
+    x = ""
+  catch
+    case e: Exception =>
+  finally
+    x = "f"
+  x.replace("", "") // ok
+
+def test4: String =
+  var x: String | Null = null
+  x = ""
+  var i: Int = 1
+  try
+    try
+      if i == 1 then
+        x = null
+        throw new Exception()
+      else
+        x = ""
+    catch
+      case _ =>
+    x = ""
+  catch
+    case _ =>
+  x.replace("", "") // error
+
+def test5: Unit =
+  var x: String | Null = null
+  var y: String | Null = null
+  x = ""
+  y = ""
+  var i: Int = 1
+  try
+    i match
+      case _ =>
+        x = null
+        throw new Exception()
+    x = ""
+  catch
+    case _ =>
+  val z1: String = x.replace("", "") // error
+  val z2: String = y.replace("", "")
\ No newline at end of file