diff --git a/openssl-sys/src/handwritten/evp.rs b/openssl-sys/src/handwritten/evp.rs
index 6d11447506..a1ae20741a 100644
--- a/openssl-sys/src/handwritten/evp.rs
+++ b/openssl-sys/src/handwritten/evp.rs
@@ -370,7 +370,7 @@ extern "C" {
     pub fn EVP_aes_256_wrap() -> *const EVP_CIPHER;
     #[cfg(ossl110)]
     pub fn EVP_aes_256_wrap_pad() -> *const EVP_CIPHER;
-    #[cfg(all(ossl110, not(osslconf = "OPENSSL_NO_CHACHA")))]
+    #[cfg(all(any(ossl110, libressl), not(osslconf = "OPENSSL_NO_CHACHA")))]
     pub fn EVP_chacha20() -> *const EVP_CIPHER;
     #[cfg(all(any(ossl110, libressl360), not(osslconf = "OPENSSL_NO_CHACHA")))]
     pub fn EVP_chacha20_poly1305() -> *const EVP_CIPHER;
diff --git a/openssl/src/cipher.rs b/openssl/src/cipher.rs
index 722847b0ef..21f2a8d8e3 100644
--- a/openssl/src/cipher.rs
+++ b/openssl/src/cipher.rs
@@ -453,7 +453,7 @@ impl Cipher {
         unsafe { CipherRef::from_ptr(ffi::EVP_idea_cbc() as *mut _) }
     }
 
-    #[cfg(all(ossl110, not(osslconf = "OPENSSL_NO_CHACHA")))]
+    #[cfg(all(any(ossl110, libressl), not(osslconf = "OPENSSL_NO_CHACHA")))]
     pub fn chacha20() -> &'static CipherRef {
         unsafe { CipherRef::from_ptr(ffi::EVP_chacha20() as *mut _) }
     }
diff --git a/openssl/src/symm.rs b/openssl/src/symm.rs
index 21cf6cb075..8e3738dac3 100644
--- a/openssl/src/symm.rs
+++ b/openssl/src/symm.rs
@@ -383,7 +383,7 @@ impl Cipher {
     }
 
     /// Requires OpenSSL 1.1.0 or newer.
-    #[cfg(all(ossl110, not(osslconf = "OPENSSL_NO_CHACHA")))]
+    #[cfg(all(any(ossl110, libressl), not(osslconf = "OPENSSL_NO_CHACHA")))]
     pub fn chacha20() -> Cipher {
         unsafe { Cipher(ffi::EVP_chacha20()) }
     }
@@ -1592,7 +1592,7 @@ mod tests {
     }
 
     #[test]
-    #[cfg(ossl110)]
+    #[cfg(any(ossl110, libressl373))]
     fn test_chacha20() {
         let key = "0000000000000000000000000000000000000000000000000000000000000000";
         let iv = "00000000000000000000000000000000";