diff --git a/tests/integ/modin/series/test_unique.py b/tests/integ/modin/series/test_unique.py
index 7c909b3ad0d..ee42e0308ab 100644
--- a/tests/integ/modin/series/test_unique.py
+++ b/tests/integ/modin/series/test_unique.py
@@ -26,7 +26,12 @@ def _make_nan_interleaved_float_series():
     [12.0, 11.999999, 11.999999],
     ["A", "A", "C", "C", "A"],
     [None, "A", None, "B"],
-    native_pd.Series([1, 2, 2**63, 2**63], dtype=np.uint64),
+    pytest.param(
+        native_pd.Series([1, 2, 2**63, 2**63], dtype=np.uint64),
+        marks=pytest.mark.xfail(
+            reason="SNOW-1356685: Dtype with unsigned int results in precision error"
+        ),
+    ),
     _make_nan_interleaved_float_series(),
 ]