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Grounding of micro-RNAs #255
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Heads up to Sumit (@maestroe) since this is relevant to our discussion for next week |
@lingling93 did a lot of work parsing miRBase in https://github.com/bio2bel/mirbase. Specifically, downloading the terminology (which includes names, identifiers, synonyms, and xrefs) can be found at https://github.com/bio2bel/mirbase/blob/master/src/bio2bel_mirbase/parser.py There's something else at https://github.com/bio2bel/mirtarbase that also gets all of the data from miRTarBase, but not as nicely in a JSON object as this |
@ddomingof there's definitely room for more. Also, looks like there are quite a few miRNAs that get missed by INDRA. See sorgerlab/indra#255 at sorgerlab/indra#255
References sorgerlab#255 This doesn't update the BioPAX processor, but at least it gives a sure-fire set of miRNA-target interactions. Right now it's lacking in the species specificity or the propagation of the experimental conditions. The database even has confidence information associated with each, so this could be used to calculate BELIEF scores.
After the last two PR's get reviewed, we might consider calling this done :) |
We actually get a pretty good amount of micro-RNAs from BioPAX and reading. The reading systems pick them up as named entities but don't have the resources to ground them. BioPAX grounds micro-RNAs to "mirtarbase", e.g. hsa-miR-26b-5p is grounded to "MIRT006307". This is an interaction database, not a micro-RNA database (like miRBase) and so we would probably need to map these IDs. So we could:
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