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Grounding of micro-RNAs #255

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bgyori opened this issue Jul 7, 2017 · 3 comments
Open

Grounding of micro-RNAs #255

bgyori opened this issue Jul 7, 2017 · 3 comments

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@bgyori
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bgyori commented Jul 7, 2017

We actually get a pretty good amount of micro-RNAs from BioPAX and reading. The reading systems pick them up as named entities but don't have the resources to ground them. BioPAX grounds micro-RNAs to "mirtarbase", e.g. hsa-miR-26b-5p is grounded to "MIRT006307". This is an interaction database, not a micro-RNA database (like miRBase) and so we would probably need to map these IDs. So we could:

  • introduce a new db_refs entry key for micro-RNAs, probably miRBase
  • map mirtarbase BioPAX grounding to miRBase db_refs
  • integrate micro-RNA resources into reading systems or grounding-map them ourselves
@cthoyt
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cthoyt commented Jan 20, 2018

Heads up to Sumit (@maestroe) since this is relevant to our discussion for next week

@cthoyt
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cthoyt commented Dec 4, 2018

@lingling93 did a lot of work parsing miRBase in https://github.com/bio2bel/mirbase. Specifically, downloading the terminology (which includes names, identifiers, synonyms, and xrefs) can be found at https://github.com/bio2bel/mirbase/blob/master/src/bio2bel_mirbase/parser.py

There's something else at https://github.com/bio2bel/mirtarbase that also gets all of the data from miRTarBase, but not as nicely in a JSON object as this

cthoyt added a commit to bit-lsi/MEN2018 that referenced this issue Feb 15, 2019
@ddomingof there's definitely room for more. Also, looks like there are quite a few miRNAs that get missed by INDRA. See sorgerlab/indra#255 at sorgerlab/indra#255
cthoyt added a commit to cthoyt/indra that referenced this issue Jul 21, 2019
References sorgerlab#255 

This doesn't update the BioPAX processor, but at least it gives a sure-fire set of miRNA-target interactions. Right now it's lacking in the species specificity or the propagation of the experimental conditions. The database even has confidence information associated with each, so this could be used to calculate BELIEF scores.
@cthoyt
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cthoyt commented Jul 21, 2019

After the last two PR's get reviewed, we might consider calling this done :)

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