forked from pvtodorov/indra_pathway_map
-
Notifications
You must be signed in to change notification settings - Fork 2
/
ras_pathway_v2.txt
119 lines (81 loc) · 4.35 KB
/
ras_pathway_v2.txt
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
CBL, CBLB, and CBLC inhibit ALK, EGFR, ERBB2, FGFR1, FGFR2, FGFR3, FGFR4, and FLT3.
CBL, CBLB, and CBLC inhibit INSR, INSRR, MET, PDGFRA, PDGFRB, ROS1.
INSR, INSRR, MET, PDGFRA, PDGFRB, ROS1 activate IRS1 and IRS2.
MTOR, RPTOR, MLST8, GRB10, RPS6KB1, and RPS6KB2 inhibit IRS1 and IRS2.
ALK, EGFR, ERBB2, FGFR1, FGFR2, FGFR3, FGFR4, and FLT3 activate the SOS1, SOS2,GRB2, and SHC.
SOS1, SOS2,GRB2, and SHC activate HRAS, NRAS, and KRAS.
SOS1, SOS2,GRB2, and SHC activate MRAS.
SOS2 binds GRB2 and SHC.
GRB2 binds SOS2 and SHC.
SHC binds SOS and GRB2.
MAPK1 and MAPK3 inhibit SOS1, SOS2,GRB2, and SHC.
RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 inhibit SOS1, SOS2,GRB2, and SHC.
RASGRP, RAPGEF, and RASGRF activate HRAS, NRAS, and KRAS.
RASGRP, RAPGEF, and RASGRF activate MRAS.
ARHGAP35, RASA1, RASA2, RASA3, RASAL1, RASAL2, RASAL3, NF1, SPRED1, SPRED2, SPRED3, DAB21P inhibit HRAS, NRAS, and KRAS.
ARHGAP35, RASA1, RASA2, RASA3, RASAL1, RASAL2, RASAL3, NF1, SPRED1, SPRED2, SPRED3, DAB21P inhibit RHOA, RHOB, and RHOC.
ARHGAP35 binds RASA1.
NF1 binds SPRED1, SPRED2, and SPRED3.
FNTA, FNTB, RCE1, and ICMT activate HRAS, NRAS, and KRAS.
FNTA, FNTB, RCE1, and ICMT activate MRAS.
FNTA binds FNTB.
PLXNB1 inhibits MRAS.
MRAS activates SHOC2 and PPP1CA.
SHOC2 binds PPP1CA.
SHOC2 and PPP1CA activates ARAF, BRAF, and RAF1.
RHOA, RHOB, and RHOC activate ROCK1 and ROCK2.
ARHGEF2, VAV1, and ECT2 activate RHOA, RHOB, and RHOC.
ROCK1 and ROCK2 activate RASSF, RALGDS, RGL1, RGL2, and RGL3, ARAF, BRAF, and RAF1, PIK3CA, PIK3CD, and PIK3CG, and PIK3R1, PIK3R2, PIK3R3, PIK3R5, and PIK3R6, and PLCE1.
RASSF activates STK3, STK4, and SAV1.
STK3 and STK4 bind SAV1.
STK3, STK4, and SAV1 activate YAP1.
RALGDS, RGL1, RGL2, and RGL3 activate RALA and RALB.
RALGAPA1 and RALGAPA2 inhibit RALA and RALB.
RALA and RALB activate RALBP1 and EXOC.
RALBP1 activates CYTH2.
EXOC activates TBK1.
TBK1 activates NFKB1.
PTPN11 activates ARAF, BRAF and RAF1.
HRAS, NRAS,, and KRAS activate ARAF, BRAF, and RAF1.
PEBP1 inhibits ARAF, BRAF, and RAF1.
PIN1 activates ARAF, BRAF, and RAF1.
SCRIB inhibits ARAF, BRAF, RAF1.
STK11 activates PRKAA1 and PRKAA2.
STK11 activates PRKAB1 and PRKAB2.
STK11 activates PRKAG1 and PRKAG2.
PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 inhibit MTOR, RPTOR, and MLST8.
RHEB inhibits MTOR, RPTOR, and MLST8.
TSC1 and TSC2 inhibit RHEB.
TSC1 binds TSC2.
AKT1, AKT2, and AKT3 inhibit TSC1 and TSC2.
PIK3CA, PIK3CD, and PIK3CG, and PIK3R1, PIK3R2, PIK3R3, PIK3R5, and PIK3R6 activate PIP3.
MAP2K1 and MAP2K2 activate PTEN.
PDPK1 activates AKT1, AKT2, and AKT3.
PIP3 activates PDPK1, ATK1, AKT2, and AKT3, TIAM1, TIAM2, and PREX2.
PTEN inhibits PIP3. INPP4B inhibits PIP3.
TIAM1, TIAM2, and PREX2 activate RAC1, RAC2, and RAC3.
RAC1, RAC2, and RAC3 activate PAK1, PAK2, PAK3, PAK4, NOX1, NFE2L2.
MTOR, RPTOR, and MLST8 inhibit EIF4BP1, EIF4BP2, EIF4BP3.
MTOR, RPTOR, and MLST8 activate GRB10.
MTOR, RPTOR, and MLST8 activate RPS6KB1 and RPS6KB2.
MTOR binds RPTOR and MLST8.
RPTOR binds MLST8.
SPRY1, SPRY2, SPRY3, and SPRY4 inhibit RASSF, RALGDS, RGL1, RGL2, and RGL3, ARAF, BRAF, and RAF1, PIK3CA, PIK3CD, and PIK3CG, and PIK3R1, PIK3R2, PIK3R3, PIK3R5, and PIK3R6, and PLCE1.
ARAF, BRAF, and RAF1 activate MAP2K1 and MAP2K2.
MAPK1 and MAPK3 inhibit ARAF, BRAF, and RAF1.
ARAF, BRAF, and RAF1 bind KSR1, KSR2, CNKSR1, and CNKSR2, MAP2K1, and MAP2K2, MAPK1, and MAPK3.
SR1, KSR2, CNKSR1, and CNKSR2, MAP2K1 bind MAP2K1, and MAP2K2, MAPK1, and MAPK3.
ERF, PEA15, DUSP1, DUSP2, DUSP3, DUSP4, DUSP5, and DUSP6 inhibit MAPK1 and MAPK3.
ETS1, ETS2, JUN, and FOS activate DUSP1, DUSP1, DUSP2, DUSP3, DUSP4, DUSP5, and DUSP6, SPRY1, SPRY2, SPRY3, and SPRY4, CCND1, CCND2, and CCND3, and MDM2.
MAPK1 and MAPK3 activate ETS1, ETS2, JUN, and FOS, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, MYC, and ELK1.
ELK1 activates ETS1, ETS2, JUN, and FOS.
CCND1, CCND2, and CCND3 activate CDK4 and CDK6.
CDK4 and CDK6 activate RB1.
RB1 inhibits E2F1, E2F2, E2F3, TFDP1, and TFDP2.
E2F1, E2F2, E2F3, TFDP1, and TFDP2 activate APAF1, BARD1, BRCA1, BRCA2, BRIP1, BUB1, CASP3, CASP7, CASP8, CCNA1, CCNA2, CDC25A, CDC6, CDK2, CDKN1A, DHFR, E2F7, FANCA, FANCC, MCM3, MCM4, MCM5, MCM6, MCM7, MYB, RAD52, TK1, TP73, TYMS, and UNG.
E2F1, E2F2, E2F3, TFDP1, and TFDP2 activate TP53.
E2F1, E2F2, E2F3, TFDP1, and TFDP2 activate RB1.
E2F1, E2F2, and E2F3 bind TFDP1.
MDM2 inhibits TP53.
TP53 activates MDM2.
RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 activate FOSL1.