diff --git a/Cargo.lock b/Cargo.lock
index f4acf157..f0de5653 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -1211,9 +1211,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3"
-version = "0.22.3"
+version = "0.22.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "15ee168e30649f7f234c3d49ef5a7a6cbf5134289bc46c29ff3155fa3221c225"
+checksum = "00e89ce2565d6044ca31a3eb79a334c3a79a841120a98f64eea9f579564cb691"
 dependencies = [
  "anyhow",
  "cfg-if",
@@ -1230,9 +1230,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-build-config"
-version = "0.22.3"
+version = "0.22.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e61cef80755fe9e46bb8a0b8f20752ca7676dcc07a5277d8b7768c6172e529b3"
+checksum = "d8afbaf3abd7325e08f35ffb8deb5892046fcb2608b703db6a583a5ba4cea01e"
 dependencies = [
  "once_cell",
  "target-lexicon",
@@ -1240,9 +1240,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-ffi"
-version = "0.22.3"
+version = "0.22.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "67ce096073ec5405f5ee2b8b31f03a68e02aa10d5d4f565eca04acc41931fa1c"
+checksum = "ec15a5ba277339d04763f4c23d85987a5b08cbb494860be141e6a10a8eb88022"
 dependencies = [
  "libc",
  "pyo3-build-config",
@@ -1250,9 +1250,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros"
-version = "0.22.3"
+version = "0.22.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2440c6d12bc8f3ae39f1e775266fa5122fd0c8891ce7520fa6048e683ad3de28"
+checksum = "15e0f01b5364bcfbb686a52fc4181d412b708a68ed20c330db9fc8d2c2bf5a43"
 dependencies = [
  "proc-macro2",
  "pyo3-macros-backend",
@@ -1262,9 +1262,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.22.3"
+version = "0.22.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1be962f0e06da8f8465729ea2cb71a416d2257dff56cbe40a70d3e62a93ae5d1"
+checksum = "a09b550200e1e5ed9176976d0060cbc2ea82dc8515da07885e7b8153a85caacb"
 dependencies = [
  "heck 0.5.0",
  "proc-macro2",
diff --git a/Cargo.toml b/Cargo.toml
index 7935aa38..3f786322 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -9,7 +9,7 @@ name = "sourmash_plugin_branchwater"
 crate-type = ["cdylib"]
 
 [dependencies]
-pyo3 = { version = "0.22.3", features = ["extension-module", "anyhow"] }
+pyo3 = { version = "0.22.4", features = ["extension-module", "anyhow"] }
 rayon = "1.10.0"
 serde = { version = "1.0.210", features = ["derive"] }
 sourmash = { version = "0.15.2", features = ["branchwater"] }