mutation_alter.ipynb

{
 "cells": [
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "import numpy as np\n",
    "import pandas as pd"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Modify mutation table"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "mut_orig = pd.DataFrame.from_csv('Sanger_molecular_data/mutations.csv', header=0, index_col=False)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "(146287, 32)"
      ]
     },
     "execution_count": 3,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "mut_orig.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "mut2 = mut_orig.dropna(subset=['Mutation.Description'])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "Gene.name                   False\n",
       "Accession.Number            False\n",
       "Gene.CDS.length             False\n",
       "HGNC.ID                      True\n",
       "cell_line_name              False\n",
       "ID_sample                   False\n",
       "ID_tumour                   False\n",
       "Primary.site                False\n",
       "Site.subtype                False\n",
       "Primary.histology           False\n",
       "Histology.subtype           False\n",
       "Genome.wide.screen          False\n",
       "Mutation.ID                 False\n",
       "Mutation.CDS                False\n",
       "Mutation.AA                 False\n",
       "Mutation.Description        False\n",
       "Mutation.zygosity           False\n",
       "GRCh                        False\n",
       "Mutation.genome.position    False\n",
       "strand                      False\n",
       "SNP                          True\n",
       "FATHMM.prediction            True\n",
       "Mutation.somatic.status     False\n",
       "Pubmed_PMID                  True\n",
       "ID_STUDY                     True\n",
       "Institute                    True\n",
       "Institute.Address            True\n",
       "Catalogue.Number             True\n",
       "Sample.source               False\n",
       "Tumour.origin               False\n",
       "Age                          True\n",
       "Comments                     True\n",
       "dtype: bool"
      ]
     },
     "execution_count": 5,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "pd.isnull(mut2).any()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "mut = mut2.copy()\n",
    "silent = mut['Mutation.Description'] == 'Substitution - coding silent'\n",
    "mut = mut.drop(mut[silent].index)\n",
    "mut = mut.drop('Accession.Number', axis=1)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "(56744, 31)"
      ]
     },
     "execution_count": 7,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "mut.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {
    "collapsed": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Gene.name</th>\n",
       "      <th>Gene.CDS.length</th>\n",
       "      <th>HGNC.ID</th>\n",
       "      <th>cell_line_name</th>\n",
       "      <th>ID_sample</th>\n",
       "      <th>ID_tumour</th>\n",
       "      <th>Primary.site</th>\n",
       "      <th>Site.subtype</th>\n",
       "      <th>Primary.histology</th>\n",
       "      <th>Histology.subtype</th>\n",
       "      <th>...</th>\n",
       "      <th>Mutation.somatic.status</th>\n",
       "      <th>Pubmed_PMID</th>\n",
       "      <th>ID_STUDY</th>\n",
       "      <th>Institute</th>\n",
       "      <th>Institute.Address</th>\n",
       "      <th>Catalogue.Number</th>\n",
       "      <th>Sample.source</th>\n",
       "      <th>Tumour.origin</th>\n",
       "      <th>Age</th>\n",
       "      <th>Comments</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>FRMD4A</td>\n",
       "      <td>3120</td>\n",
       "      <td>25491</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Reported in another cancer sample as somatic</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>LILRB1</td>\n",
       "      <td>1953</td>\n",
       "      <td>6605</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Reported in another cancer sample as somatic</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>FAM110B</td>\n",
       "      <td>1113</td>\n",
       "      <td>28587</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Reported in another cancer sample as somatic</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>WDR96</td>\n",
       "      <td>4998</td>\n",
       "      <td>26684</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Reported in another cancer sample as somatic</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>TCF12</td>\n",
       "      <td>2121</td>\n",
       "      <td>11623</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Reported in another cancer sample as somatic</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>TCF12_ENST00000452095</td>\n",
       "      <td>2109</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Reported in another cancer sample as somatic</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>SLIT1</td>\n",
       "      <td>4605</td>\n",
       "      <td>11085</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>PPM1G</td>\n",
       "      <td>1641</td>\n",
       "      <td>9278</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>SERPINA12</td>\n",
       "      <td>1245</td>\n",
       "      <td>18359</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>KANK4</td>\n",
       "      <td>2988</td>\n",
       "      <td>27263</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>ABCA10</td>\n",
       "      <td>4632</td>\n",
       "      <td>30</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>NADK_ENST00000342348</td>\n",
       "      <td>1245</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>CAMK1G</td>\n",
       "      <td>1431</td>\n",
       "      <td>14585</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Reported in another cancer sample as somatic</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>NTF3</td>\n",
       "      <td>774</td>\n",
       "      <td>8023</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>SFRP5</td>\n",
       "      <td>954</td>\n",
       "      <td>10779</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>CNTN5_ENST00000524871</td>\n",
       "      <td>3303</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>MICAL2_ENST00000379612</td>\n",
       "      <td>2931</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>FCRL2</td>\n",
       "      <td>1527</td>\n",
       "      <td>14875</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>OTOGL_ENST00000458043</td>\n",
       "      <td>7035</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>LRRIQ1_ENST00000393217</td>\n",
       "      <td>5169</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>LRRIQ1</td>\n",
       "      <td>4011</td>\n",
       "      <td>25708</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>ANKLE2</td>\n",
       "      <td>2817</td>\n",
       "      <td>29101</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>KIAA1199</td>\n",
       "      <td>4086</td>\n",
       "      <td>29213</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>KIAA1199</td>\n",
       "      <td>4086</td>\n",
       "      <td>29213</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>28</th>\n",
       "      <td>UCP2</td>\n",
       "      <td>930</td>\n",
       "      <td>12518</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>30</th>\n",
       "      <td>TECPR2</td>\n",
       "      <td>4236</td>\n",
       "      <td>19957</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>33</th>\n",
       "      <td>MS4A8B</td>\n",
       "      <td>753</td>\n",
       "      <td>13380</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>35</th>\n",
       "      <td>PLEKHS1</td>\n",
       "      <td>1398</td>\n",
       "      <td>NaN</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>37</th>\n",
       "      <td>POSTN</td>\n",
       "      <td>2511</td>\n",
       "      <td>16953</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>38</th>\n",
       "      <td>ATP10A</td>\n",
       "      <td>4500</td>\n",
       "      <td>13542</td>\n",
       "      <td>HCC1806</td>\n",
       "      <td>907047</td>\n",
       "      <td>824559</td>\n",
       "      <td>breast</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>ductal_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-2335</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>primary</td>\n",
       "      <td>60</td>\n",
       "      <td>Grade:II,Stage:II</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145473</th>\n",
       "      <td>DYNC2H1_ENST00000398093</td>\n",
       "      <td>5244</td>\n",
       "      <td>2962</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145474</th>\n",
       "      <td>ATP6V1C1</td>\n",
       "      <td>1149</td>\n",
       "      <td>856</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145475</th>\n",
       "      <td>ANKRD17</td>\n",
       "      <td>7812</td>\n",
       "      <td>23575</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145480</th>\n",
       "      <td>CIT_ENST00000392521</td>\n",
       "      <td>6210</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145481</th>\n",
       "      <td>FAM5C</td>\n",
       "      <td>2301</td>\n",
       "      <td>22393</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145482</th>\n",
       "      <td>DCAF12L1</td>\n",
       "      <td>1392</td>\n",
       "      <td>29395</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145483</th>\n",
       "      <td>GDF5</td>\n",
       "      <td>1506</td>\n",
       "      <td>4220</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145485</th>\n",
       "      <td>PDE4B_ENST00000423207</td>\n",
       "      <td>2166</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145486</th>\n",
       "      <td>TTN_ENST00000342992</td>\n",
       "      <td>100272</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145489</th>\n",
       "      <td>C6orf163</td>\n",
       "      <td>612</td>\n",
       "      <td>21403</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145490</th>\n",
       "      <td>NRCAM_ENST00000379022</td>\n",
       "      <td>3711</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145493</th>\n",
       "      <td>INPP4B_ENST00000513000</td>\n",
       "      <td>2775</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145494</th>\n",
       "      <td>BCL9L_ENST00000334801</td>\n",
       "      <td>4500</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145495</th>\n",
       "      <td>TBP</td>\n",
       "      <td>1020</td>\n",
       "      <td>11588</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145496</th>\n",
       "      <td>GDF5OS</td>\n",
       "      <td>753</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145497</th>\n",
       "      <td>SLC24A4_ENST00000532405</td>\n",
       "      <td>1869</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145498</th>\n",
       "      <td>TOP1MT</td>\n",
       "      <td>1806</td>\n",
       "      <td>29787</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145499</th>\n",
       "      <td>ABCA13</td>\n",
       "      <td>15012</td>\n",
       "      <td>14638</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145500</th>\n",
       "      <td>COL22A1</td>\n",
       "      <td>4881</td>\n",
       "      <td>22989</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145501</th>\n",
       "      <td>FGF10</td>\n",
       "      <td>627</td>\n",
       "      <td>3666</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145605</th>\n",
       "      <td>KCNB2</td>\n",
       "      <td>2736</td>\n",
       "      <td>6232</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145606</th>\n",
       "      <td>PCLO_ENST00000423517</td>\n",
       "      <td>14808</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145662</th>\n",
       "      <td>ANKRD30BL</td>\n",
       "      <td>777</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145671</th>\n",
       "      <td>GCK_ENST00000403799</td>\n",
       "      <td>1398</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145790</th>\n",
       "      <td>BFAR</td>\n",
       "      <td>1353</td>\n",
       "      <td>17613</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>145830</th>\n",
       "      <td>C2CD3</td>\n",
       "      <td>5892</td>\n",
       "      <td>24564</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>146047</th>\n",
       "      <td>SLC25A48_ENST00000420621</td>\n",
       "      <td>936</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>146182</th>\n",
       "      <td>PCDHB13</td>\n",
       "      <td>2397</td>\n",
       "      <td>8684</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>146189</th>\n",
       "      <td>SPANXN1</td>\n",
       "      <td>219</td>\n",
       "      <td>33174</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>146238</th>\n",
       "      <td>LAMB1</td>\n",
       "      <td>5361</td>\n",
       "      <td>6486</td>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>724831</td>\n",
       "      <td>615951</td>\n",
       "      <td>lung</td>\n",
       "      <td>NS</td>\n",
       "      <td>carcinoma</td>\n",
       "      <td>non_small_cell_carcinoma</td>\n",
       "      <td>...</td>\n",
       "      <td>Variant of unknown origin</td>\n",
       "      <td>NaN</td>\n",
       "      <td>NaN</td>\n",
       "      <td>American Type Culture Collection (ATCC)</td>\n",
       "      <td>P.O. Box 1549, Manassas, VA 20108, USA</td>\n",
       "      <td>CRL-5803</td>\n",
       "      <td>cell-line</td>\n",
       "      <td>metastasis</td>\n",
       "      <td>43</td>\n",
       "      <td>Metastatic site:lymph node</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>56744 rows × 31 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                       Gene.name  Gene.CDS.length  HGNC.ID cell_line_name  \\\n",
       "0                         FRMD4A             3120    25491        HCC1806   \n",
       "1                         LILRB1             1953     6605        HCC1806   \n",
       "2                        FAM110B             1113    28587        HCC1806   \n",
       "3                          WDR96             4998    26684        HCC1806   \n",
       "4                          TCF12             2121    11623        HCC1806   \n",
       "5          TCF12_ENST00000452095             2109      NaN        HCC1806   \n",
       "6                          SLIT1             4605    11085        HCC1806   \n",
       "7                          PPM1G             1641     9278        HCC1806   \n",
       "8                      SERPINA12             1245    18359        HCC1806   \n",
       "9                          KANK4             2988    27263        HCC1806   \n",
       "10                        ABCA10             4632       30        HCC1806   \n",
       "11          NADK_ENST00000342348             1245      NaN        HCC1806   \n",
       "12                        CAMK1G             1431    14585        HCC1806   \n",
       "13                          NTF3              774     8023        HCC1806   \n",
       "15                         SFRP5              954    10779        HCC1806   \n",
       "16         CNTN5_ENST00000524871             3303      NaN        HCC1806   \n",
       "17        MICAL2_ENST00000379612             2931      NaN        HCC1806   \n",
       "18                         FCRL2             1527    14875        HCC1806   \n",
       "19         OTOGL_ENST00000458043             7035      NaN        HCC1806   \n",
       "20        LRRIQ1_ENST00000393217             5169      NaN        HCC1806   \n",
       "21                        LRRIQ1             4011    25708        HCC1806   \n",
       "23                        ANKLE2             2817    29101        HCC1806   \n",
       "25                      KIAA1199             4086    29213        HCC1806   \n",
       "26                      KIAA1199             4086    29213        HCC1806   \n",
       "28                          UCP2              930    12518        HCC1806   \n",
       "30                        TECPR2             4236    19957        HCC1806   \n",
       "33                        MS4A8B              753    13380        HCC1806   \n",
       "35                       PLEKHS1             1398      NaN        HCC1806   \n",
       "37                         POSTN             2511    16953        HCC1806   \n",
       "38                        ATP10A             4500    13542        HCC1806   \n",
       "...                          ...              ...      ...            ...   \n",
       "145473   DYNC2H1_ENST00000398093             5244     2962      NCI-H1299   \n",
       "145474                  ATP6V1C1             1149      856      NCI-H1299   \n",
       "145475                   ANKRD17             7812    23575      NCI-H1299   \n",
       "145480       CIT_ENST00000392521             6210      NaN      NCI-H1299   \n",
       "145481                     FAM5C             2301    22393      NCI-H1299   \n",
       "145482                  DCAF12L1             1392    29395      NCI-H1299   \n",
       "145483                      GDF5             1506     4220      NCI-H1299   \n",
       "145485     PDE4B_ENST00000423207             2166      NaN      NCI-H1299   \n",
       "145486       TTN_ENST00000342992           100272      NaN      NCI-H1299   \n",
       "145489                  C6orf163              612    21403      NCI-H1299   \n",
       "145490     NRCAM_ENST00000379022             3711      NaN      NCI-H1299   \n",
       "145493    INPP4B_ENST00000513000             2775      NaN      NCI-H1299   \n",
       "145494     BCL9L_ENST00000334801             4500      NaN      NCI-H1299   \n",
       "145495                       TBP             1020    11588      NCI-H1299   \n",
       "145496                    GDF5OS              753      NaN      NCI-H1299   \n",
       "145497   SLC24A4_ENST00000532405             1869      NaN      NCI-H1299   \n",
       "145498                    TOP1MT             1806    29787      NCI-H1299   \n",
       "145499                    ABCA13            15012    14638      NCI-H1299   \n",
       "145500                   COL22A1             4881    22989      NCI-H1299   \n",
       "145501                     FGF10              627     3666      NCI-H1299   \n",
       "145605                     KCNB2             2736     6232      NCI-H1299   \n",
       "145606      PCLO_ENST00000423517            14808      NaN      NCI-H1299   \n",
       "145662                 ANKRD30BL              777      NaN      NCI-H1299   \n",
       "145671       GCK_ENST00000403799             1398      NaN      NCI-H1299   \n",
       "145790                      BFAR             1353    17613      NCI-H1299   \n",
       "145830                     C2CD3             5892    24564      NCI-H1299   \n",
       "146047  SLC25A48_ENST00000420621              936      NaN      NCI-H1299   \n",
       "146182                   PCDHB13             2397     8684      NCI-H1299   \n",
       "146189                   SPANXN1              219    33174      NCI-H1299   \n",
       "146238                     LAMB1             5361     6486      NCI-H1299   \n",
       "\n",
       "        ID_sample  ID_tumour Primary.site Site.subtype Primary.histology  \\\n",
       "0          907047     824559       breast           NS         carcinoma   \n",
       "1          907047     824559       breast           NS         carcinoma   \n",
       "2          907047     824559       breast           NS         carcinoma   \n",
       "3          907047     824559       breast           NS         carcinoma   \n",
       "4          907047     824559       breast           NS         carcinoma   \n",
       "5          907047     824559       breast           NS         carcinoma   \n",
       "6          907047     824559       breast           NS         carcinoma   \n",
       "7          907047     824559       breast           NS         carcinoma   \n",
       "8          907047     824559       breast           NS         carcinoma   \n",
       "9          907047     824559       breast           NS         carcinoma   \n",
       "10         907047     824559       breast           NS         carcinoma   \n",
       "11         907047     824559       breast           NS         carcinoma   \n",
       "12         907047     824559       breast           NS         carcinoma   \n",
       "13         907047     824559       breast           NS         carcinoma   \n",
       "15         907047     824559       breast           NS         carcinoma   \n",
       "16         907047     824559       breast           NS         carcinoma   \n",
       "17         907047     824559       breast           NS         carcinoma   \n",
       "18         907047     824559       breast           NS         carcinoma   \n",
       "19         907047     824559       breast           NS         carcinoma   \n",
       "20         907047     824559       breast           NS         carcinoma   \n",
       "21         907047     824559       breast           NS         carcinoma   \n",
       "23         907047     824559       breast           NS         carcinoma   \n",
       "25         907047     824559       breast           NS         carcinoma   \n",
       "26         907047     824559       breast           NS         carcinoma   \n",
       "28         907047     824559       breast           NS         carcinoma   \n",
       "30         907047     824559       breast           NS         carcinoma   \n",
       "33         907047     824559       breast           NS         carcinoma   \n",
       "35         907047     824559       breast           NS         carcinoma   \n",
       "37         907047     824559       breast           NS         carcinoma   \n",
       "38         907047     824559       breast           NS         carcinoma   \n",
       "...           ...        ...          ...          ...               ...   \n",
       "145473     724831     615951         lung           NS         carcinoma   \n",
       "145474     724831     615951         lung           NS         carcinoma   \n",
       "145475     724831     615951         lung           NS         carcinoma   \n",
       "145480     724831     615951         lung           NS         carcinoma   \n",
       "145481     724831     615951         lung           NS         carcinoma   \n",
       "145482     724831     615951         lung           NS         carcinoma   \n",
       "145483     724831     615951         lung           NS         carcinoma   \n",
       "145485     724831     615951         lung           NS         carcinoma   \n",
       "145486     724831     615951         lung           NS         carcinoma   \n",
       "145489     724831     615951         lung           NS         carcinoma   \n",
       "145490     724831     615951         lung           NS         carcinoma   \n",
       "145493     724831     615951         lung           NS         carcinoma   \n",
       "145494     724831     615951         lung           NS         carcinoma   \n",
       "145495     724831     615951         lung           NS         carcinoma   \n",
       "145496     724831     615951         lung           NS         carcinoma   \n",
       "145497     724831     615951         lung           NS         carcinoma   \n",
       "145498     724831     615951         lung           NS         carcinoma   \n",
       "145499     724831     615951         lung           NS         carcinoma   \n",
       "145500     724831     615951         lung           NS         carcinoma   \n",
       "145501     724831     615951         lung           NS         carcinoma   \n",
       "145605     724831     615951         lung           NS         carcinoma   \n",
       "145606     724831     615951         lung           NS         carcinoma   \n",
       "145662     724831     615951         lung           NS         carcinoma   \n",
       "145671     724831     615951         lung           NS         carcinoma   \n",
       "145790     724831     615951         lung           NS         carcinoma   \n",
       "145830     724831     615951         lung           NS         carcinoma   \n",
       "146047     724831     615951         lung           NS         carcinoma   \n",
       "146182     724831     615951         lung           NS         carcinoma   \n",
       "146189     724831     615951         lung           NS         carcinoma   \n",
       "146238     724831     615951         lung           NS         carcinoma   \n",
       "\n",
       "               Histology.subtype             ...              \\\n",
       "0               ductal_carcinoma             ...               \n",
       "1               ductal_carcinoma             ...               \n",
       "2               ductal_carcinoma             ...               \n",
       "3               ductal_carcinoma             ...               \n",
       "4               ductal_carcinoma             ...               \n",
       "5               ductal_carcinoma             ...               \n",
       "6               ductal_carcinoma             ...               \n",
       "7               ductal_carcinoma             ...               \n",
       "8               ductal_carcinoma             ...               \n",
       "9               ductal_carcinoma             ...               \n",
       "10              ductal_carcinoma             ...               \n",
       "11              ductal_carcinoma             ...               \n",
       "12              ductal_carcinoma             ...               \n",
       "13              ductal_carcinoma             ...               \n",
       "15              ductal_carcinoma             ...               \n",
       "16              ductal_carcinoma             ...               \n",
       "17              ductal_carcinoma             ...               \n",
       "18              ductal_carcinoma             ...               \n",
       "19              ductal_carcinoma             ...               \n",
       "20              ductal_carcinoma             ...               \n",
       "21              ductal_carcinoma             ...               \n",
       "23              ductal_carcinoma             ...               \n",
       "25              ductal_carcinoma             ...               \n",
       "26              ductal_carcinoma             ...               \n",
       "28              ductal_carcinoma             ...               \n",
       "30              ductal_carcinoma             ...               \n",
       "33              ductal_carcinoma             ...               \n",
       "35              ductal_carcinoma             ...               \n",
       "37              ductal_carcinoma             ...               \n",
       "38              ductal_carcinoma             ...               \n",
       "...                          ...             ...               \n",
       "145473  non_small_cell_carcinoma             ...               \n",
       "145474  non_small_cell_carcinoma             ...               \n",
       "145475  non_small_cell_carcinoma             ...               \n",
       "145480  non_small_cell_carcinoma             ...               \n",
       "145481  non_small_cell_carcinoma             ...               \n",
       "145482  non_small_cell_carcinoma             ...               \n",
       "145483  non_small_cell_carcinoma             ...               \n",
       "145485  non_small_cell_carcinoma             ...               \n",
       "145486  non_small_cell_carcinoma             ...               \n",
       "145489  non_small_cell_carcinoma             ...               \n",
       "145490  non_small_cell_carcinoma             ...               \n",
       "145493  non_small_cell_carcinoma             ...               \n",
       "145494  non_small_cell_carcinoma             ...               \n",
       "145495  non_small_cell_carcinoma             ...               \n",
       "145496  non_small_cell_carcinoma             ...               \n",
       "145497  non_small_cell_carcinoma             ...               \n",
       "145498  non_small_cell_carcinoma             ...               \n",
       "145499  non_small_cell_carcinoma             ...               \n",
       "145500  non_small_cell_carcinoma             ...               \n",
       "145501  non_small_cell_carcinoma             ...               \n",
       "145605  non_small_cell_carcinoma             ...               \n",
       "145606  non_small_cell_carcinoma             ...               \n",
       "145662  non_small_cell_carcinoma             ...               \n",
       "145671  non_small_cell_carcinoma             ...               \n",
       "145790  non_small_cell_carcinoma             ...               \n",
       "145830  non_small_cell_carcinoma             ...               \n",
       "146047  non_small_cell_carcinoma             ...               \n",
       "146182  non_small_cell_carcinoma             ...               \n",
       "146189  non_small_cell_carcinoma             ...               \n",
       "146238  non_small_cell_carcinoma             ...               \n",
       "\n",
       "                             Mutation.somatic.status Pubmed_PMID ID_STUDY  \\\n",
       "0       Reported in another cancer sample as somatic         NaN      NaN   \n",
       "1       Reported in another cancer sample as somatic         NaN      NaN   \n",
       "2       Reported in another cancer sample as somatic         NaN      NaN   \n",
       "3       Reported in another cancer sample as somatic         NaN      NaN   \n",
       "4       Reported in another cancer sample as somatic         NaN      NaN   \n",
       "5       Reported in another cancer sample as somatic         NaN      NaN   \n",
       "6                          Variant of unknown origin         NaN      NaN   \n",
       "7                          Variant of unknown origin         NaN      NaN   \n",
       "8                          Variant of unknown origin         NaN      NaN   \n",
       "9                          Variant of unknown origin         NaN      NaN   \n",
       "10                         Variant of unknown origin         NaN      NaN   \n",
       "11                         Variant of unknown origin         NaN      NaN   \n",
       "12      Reported in another cancer sample as somatic         NaN      NaN   \n",
       "13                         Variant of unknown origin         NaN      NaN   \n",
       "15                         Variant of unknown origin         NaN      NaN   \n",
       "16                         Variant of unknown origin         NaN      NaN   \n",
       "17                         Variant of unknown origin         NaN      NaN   \n",
       "18                         Variant of unknown origin         NaN      NaN   \n",
       "19                         Variant of unknown origin         NaN      NaN   \n",
       "20                         Variant of unknown origin         NaN      NaN   \n",
       "21                         Variant of unknown origin         NaN      NaN   \n",
       "23                         Variant of unknown origin         NaN      NaN   \n",
       "25                         Variant of unknown origin         NaN      NaN   \n",
       "26                         Variant of unknown origin         NaN      NaN   \n",
       "28                         Variant of unknown origin         NaN      NaN   \n",
       "30                         Variant of unknown origin         NaN      NaN   \n",
       "33                         Variant of unknown origin         NaN      NaN   \n",
       "35                         Variant of unknown origin         NaN      NaN   \n",
       "37                         Variant of unknown origin         NaN      NaN   \n",
       "38                         Variant of unknown origin         NaN      NaN   \n",
       "...                                              ...         ...      ...   \n",
       "145473                     Variant of unknown origin         NaN      NaN   \n",
       "145474                     Variant of unknown origin         NaN      NaN   \n",
       "145475                     Variant of unknown origin         NaN      NaN   \n",
       "145480                     Variant of unknown origin         NaN      NaN   \n",
       "145481                     Variant of unknown origin         NaN      NaN   \n",
       "145482                     Variant of unknown origin         NaN      NaN   \n",
       "145483                     Variant of unknown origin         NaN      NaN   \n",
       "145485                     Variant of unknown origin         NaN      NaN   \n",
       "145486                     Variant of unknown origin         NaN      NaN   \n",
       "145489                     Variant of unknown origin         NaN      NaN   \n",
       "145490                     Variant of unknown origin         NaN      NaN   \n",
       "145493                     Variant of unknown origin         NaN      NaN   \n",
       "145494                     Variant of unknown origin         NaN      NaN   \n",
       "145495                     Variant of unknown origin         NaN      NaN   \n",
       "145496                     Variant of unknown origin         NaN      NaN   \n",
       "145497                     Variant of unknown origin         NaN      NaN   \n",
       "145498                     Variant of unknown origin         NaN      NaN   \n",
       "145499                     Variant of unknown origin         NaN      NaN   \n",
       "145500                     Variant of unknown origin         NaN      NaN   \n",
       "145501                     Variant of unknown origin         NaN      NaN   \n",
       "145605                     Variant of unknown origin         NaN      NaN   \n",
       "145606                     Variant of unknown origin         NaN      NaN   \n",
       "145662                     Variant of unknown origin         NaN      NaN   \n",
       "145671                     Variant of unknown origin         NaN      NaN   \n",
       "145790                     Variant of unknown origin         NaN      NaN   \n",
       "145830                     Variant of unknown origin         NaN      NaN   \n",
       "146047                     Variant of unknown origin         NaN      NaN   \n",
       "146182                     Variant of unknown origin         NaN      NaN   \n",
       "146189                     Variant of unknown origin         NaN      NaN   \n",
       "146238                     Variant of unknown origin         NaN      NaN   \n",
       "\n",
       "                                      Institute  \\\n",
       "0       American Type Culture Collection (ATCC)   \n",
       "1       American Type Culture Collection (ATCC)   \n",
       "2       American Type Culture Collection (ATCC)   \n",
       "3       American Type Culture Collection (ATCC)   \n",
       "4       American Type Culture Collection (ATCC)   \n",
       "5       American Type Culture Collection (ATCC)   \n",
       "6       American Type Culture Collection (ATCC)   \n",
       "7       American Type Culture Collection (ATCC)   \n",
       "8       American Type Culture Collection (ATCC)   \n",
       "9       American Type Culture Collection (ATCC)   \n",
       "10      American Type Culture Collection (ATCC)   \n",
       "11      American Type Culture Collection (ATCC)   \n",
       "12      American Type Culture Collection (ATCC)   \n",
       "13      American Type Culture Collection (ATCC)   \n",
       "15      American Type Culture Collection (ATCC)   \n",
       "16      American Type Culture Collection (ATCC)   \n",
       "17      American Type Culture Collection (ATCC)   \n",
       "18      American Type Culture Collection (ATCC)   \n",
       "19      American Type Culture Collection (ATCC)   \n",
       "20      American Type Culture Collection (ATCC)   \n",
       "21      American Type Culture Collection (ATCC)   \n",
       "23      American Type Culture Collection (ATCC)   \n",
       "25      American Type Culture Collection (ATCC)   \n",
       "26      American Type Culture Collection (ATCC)   \n",
       "28      American Type Culture Collection (ATCC)   \n",
       "30      American Type Culture Collection (ATCC)   \n",
       "33      American Type Culture Collection (ATCC)   \n",
       "35      American Type Culture Collection (ATCC)   \n",
       "37      American Type Culture Collection (ATCC)   \n",
       "38      American Type Culture Collection (ATCC)   \n",
       "...                                         ...   \n",
       "145473  American Type Culture Collection (ATCC)   \n",
       "145474  American Type Culture Collection (ATCC)   \n",
       "145475  American Type Culture Collection (ATCC)   \n",
       "145480  American Type Culture Collection (ATCC)   \n",
       "145481  American Type Culture Collection (ATCC)   \n",
       "145482  American Type Culture Collection (ATCC)   \n",
       "145483  American Type Culture Collection (ATCC)   \n",
       "145485  American Type Culture Collection (ATCC)   \n",
       "145486  American Type Culture Collection (ATCC)   \n",
       "145489  American Type Culture Collection (ATCC)   \n",
       "145490  American Type Culture Collection (ATCC)   \n",
       "145493  American Type Culture Collection (ATCC)   \n",
       "145494  American Type Culture Collection (ATCC)   \n",
       "145495  American Type Culture Collection (ATCC)   \n",
       "145496  American Type Culture Collection (ATCC)   \n",
       "145497  American Type Culture Collection (ATCC)   \n",
       "145498  American Type Culture Collection (ATCC)   \n",
       "145499  American Type Culture Collection (ATCC)   \n",
       "145500  American Type Culture Collection (ATCC)   \n",
       "145501  American Type Culture Collection (ATCC)   \n",
       "145605  American Type Culture Collection (ATCC)   \n",
       "145606  American Type Culture Collection (ATCC)   \n",
       "145662  American Type Culture Collection (ATCC)   \n",
       "145671  American Type Culture Collection (ATCC)   \n",
       "145790  American Type Culture Collection (ATCC)   \n",
       "145830  American Type Culture Collection (ATCC)   \n",
       "146047  American Type Culture Collection (ATCC)   \n",
       "146182  American Type Culture Collection (ATCC)   \n",
       "146189  American Type Culture Collection (ATCC)   \n",
       "146238  American Type Culture Collection (ATCC)   \n",
       "\n",
       "                             Institute.Address Catalogue.Number  \\\n",
       "0       P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "1       P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "2       P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "3       P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "4       P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "5       P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "6       P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "7       P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "8       P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "9       P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "10      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "11      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "12      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "13      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "15      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "16      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "17      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "18      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "19      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "20      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "21      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "23      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "25      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "26      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "28      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "30      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "33      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "35      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "37      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "38      P.O. Box 1549, Manassas, VA 20108, USA         CRL-2335   \n",
       "...                                        ...              ...   \n",
       "145473  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145474  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145475  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145480  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145481  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145482  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145483  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145485  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145486  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145489  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145490  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145493  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145494  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145495  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145496  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145497  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145498  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145499  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145500  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145501  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145605  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145606  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145662  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145671  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145790  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "145830  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "146047  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "146182  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "146189  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "146238  P.O. Box 1549, Manassas, VA 20108, USA         CRL-5803   \n",
       "\n",
       "        Sample.source Tumour.origin Age                    Comments  \n",
       "0           cell-line       primary  60           Grade:II,Stage:II  \n",
       "1           cell-line       primary  60           Grade:II,Stage:II  \n",
       "2           cell-line       primary  60           Grade:II,Stage:II  \n",
       "3           cell-line       primary  60           Grade:II,Stage:II  \n",
       "4           cell-line       primary  60           Grade:II,Stage:II  \n",
       "5           cell-line       primary  60           Grade:II,Stage:II  \n",
       "6           cell-line       primary  60           Grade:II,Stage:II  \n",
       "7           cell-line       primary  60           Grade:II,Stage:II  \n",
       "8           cell-line       primary  60           Grade:II,Stage:II  \n",
       "9           cell-line       primary  60           Grade:II,Stage:II  \n",
       "10          cell-line       primary  60           Grade:II,Stage:II  \n",
       "11          cell-line       primary  60           Grade:II,Stage:II  \n",
       "12          cell-line       primary  60           Grade:II,Stage:II  \n",
       "13          cell-line       primary  60           Grade:II,Stage:II  \n",
       "15          cell-line       primary  60           Grade:II,Stage:II  \n",
       "16          cell-line       primary  60           Grade:II,Stage:II  \n",
       "17          cell-line       primary  60           Grade:II,Stage:II  \n",
       "18          cell-line       primary  60           Grade:II,Stage:II  \n",
       "19          cell-line       primary  60           Grade:II,Stage:II  \n",
       "20          cell-line       primary  60           Grade:II,Stage:II  \n",
       "21          cell-line       primary  60           Grade:II,Stage:II  \n",
       "23          cell-line       primary  60           Grade:II,Stage:II  \n",
       "25          cell-line       primary  60           Grade:II,Stage:II  \n",
       "26          cell-line       primary  60           Grade:II,Stage:II  \n",
       "28          cell-line       primary  60           Grade:II,Stage:II  \n",
       "30          cell-line       primary  60           Grade:II,Stage:II  \n",
       "33          cell-line       primary  60           Grade:II,Stage:II  \n",
       "35          cell-line       primary  60           Grade:II,Stage:II  \n",
       "37          cell-line       primary  60           Grade:II,Stage:II  \n",
       "38          cell-line       primary  60           Grade:II,Stage:II  \n",
       "...               ...           ...  ..                         ...  \n",
       "145473      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145474      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145475      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145480      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145481      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145482      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145483      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145485      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145486      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145489      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145490      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145493      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145494      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145495      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145496      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145497      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145498      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145499      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145500      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145501      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145605      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145606      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145662      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145671      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145790      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "145830      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "146047      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "146182      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "146189      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "146238      cell-line    metastasis  43  Metastatic site:lymph node  \n",
       "\n",
       "[56744 rows x 31 columns]"
      ]
     },
     "execution_count": 8,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "mut"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Gene expression filter"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "gex = pd.DataFrame.from_csv('Sanger_molecular_data/gex.csv')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {
    "collapsed": false,
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>22RV1</th>\n",
       "      <th>647-V</th>\n",
       "      <th>A549</th>\n",
       "      <th>BFTC-905</th>\n",
       "      <th>BT-20</th>\n",
       "      <th>BT-474</th>\n",
       "      <th>BT-549</th>\n",
       "      <th>C32</th>\n",
       "      <th>CAL-120</th>\n",
       "      <th>CAL-148</th>\n",
       "      <th>...</th>\n",
       "      <th>SW837</th>\n",
       "      <th>SW900</th>\n",
       "      <th>SW948</th>\n",
       "      <th>T-24</th>\n",
       "      <th>T47D</th>\n",
       "      <th>TCCSUP</th>\n",
       "      <th>UACC-812</th>\n",
       "      <th>UM-UC-3</th>\n",
       "      <th>VCaP</th>\n",
       "      <th>VM-CUB-1</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>TSPAN6</th>\n",
       "      <td>4.804487</td>\n",
       "      <td>8.713556</td>\n",
       "      <td>8.495961</td>\n",
       "      <td>7.813436</td>\n",
       "      <td>7.971621</td>\n",
       "      <td>5.178131</td>\n",
       "      <td>6.383148</td>\n",
       "      <td>5.542645</td>\n",
       "      <td>7.632023</td>\n",
       "      <td>8.121539</td>\n",
       "      <td>...</td>\n",
       "      <td>8.141044</td>\n",
       "      <td>7.755154</td>\n",
       "      <td>7.709982</td>\n",
       "      <td>7.788981</td>\n",
       "      <td>7.342996</td>\n",
       "      <td>7.401340</td>\n",
       "      <td>7.086304</td>\n",
       "      <td>6.410431</td>\n",
       "      <td>5.348023</td>\n",
       "      <td>7.187071</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TNMD</th>\n",
       "      <td>2.848128</td>\n",
       "      <td>2.834723</td>\n",
       "      <td>2.886997</td>\n",
       "      <td>2.879330</td>\n",
       "      <td>2.792528</td>\n",
       "      <td>3.015506</td>\n",
       "      <td>2.746627</td>\n",
       "      <td>2.736643</td>\n",
       "      <td>2.964585</td>\n",
       "      <td>2.990916</td>\n",
       "      <td>...</td>\n",
       "      <td>2.911450</td>\n",
       "      <td>2.816921</td>\n",
       "      <td>3.212680</td>\n",
       "      <td>2.984905</td>\n",
       "      <td>2.819535</td>\n",
       "      <td>2.724977</td>\n",
       "      <td>2.952920</td>\n",
       "      <td>2.795879</td>\n",
       "      <td>2.988278</td>\n",
       "      <td>2.691417</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>DPM1</th>\n",
       "      <td>10.331994</td>\n",
       "      <td>10.504748</td>\n",
       "      <td>9.643436</td>\n",
       "      <td>10.272719</td>\n",
       "      <td>10.601207</td>\n",
       "      <td>10.548792</td>\n",
       "      <td>10.392289</td>\n",
       "      <td>9.890112</td>\n",
       "      <td>10.379553</td>\n",
       "      <td>10.359588</td>\n",
       "      <td>...</td>\n",
       "      <td>10.072444</td>\n",
       "      <td>10.214976</td>\n",
       "      <td>10.170757</td>\n",
       "      <td>10.558936</td>\n",
       "      <td>10.786582</td>\n",
       "      <td>9.864280</td>\n",
       "      <td>11.536803</td>\n",
       "      <td>10.326887</td>\n",
       "      <td>9.000925</td>\n",
       "      <td>10.184775</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SCYL3</th>\n",
       "      <td>5.145387</td>\n",
       "      <td>3.792188</td>\n",
       "      <td>4.154471</td>\n",
       "      <td>4.050385</td>\n",
       "      <td>5.622674</td>\n",
       "      <td>5.829252</td>\n",
       "      <td>3.802817</td>\n",
       "      <td>3.346422</td>\n",
       "      <td>3.614794</td>\n",
       "      <td>5.680584</td>\n",
       "      <td>...</td>\n",
       "      <td>4.531813</td>\n",
       "      <td>4.388774</td>\n",
       "      <td>4.606470</td>\n",
       "      <td>3.789149</td>\n",
       "      <td>4.677363</td>\n",
       "      <td>3.843770</td>\n",
       "      <td>4.520248</td>\n",
       "      <td>3.512380</td>\n",
       "      <td>4.306414</td>\n",
       "      <td>3.512961</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>C1orf112</th>\n",
       "      <td>3.545193</td>\n",
       "      <td>3.946664</td>\n",
       "      <td>3.307310</td>\n",
       "      <td>3.701491</td>\n",
       "      <td>3.740521</td>\n",
       "      <td>3.800657</td>\n",
       "      <td>4.379548</td>\n",
       "      <td>3.067727</td>\n",
       "      <td>3.380681</td>\n",
       "      <td>4.056182</td>\n",
       "      <td>...</td>\n",
       "      <td>3.619282</td>\n",
       "      <td>3.946621</td>\n",
       "      <td>3.858040</td>\n",
       "      <td>3.674749</td>\n",
       "      <td>3.482290</td>\n",
       "      <td>4.383248</td>\n",
       "      <td>3.324127</td>\n",
       "      <td>3.291974</td>\n",
       "      <td>3.414812</td>\n",
       "      <td>3.823379</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FGR</th>\n",
       "      <td>2.981772</td>\n",
       "      <td>3.106757</td>\n",
       "      <td>3.132815</td>\n",
       "      <td>3.036505</td>\n",
       "      <td>3.377295</td>\n",
       "      <td>3.446415</td>\n",
       "      <td>3.183691</td>\n",
       "      <td>3.253538</td>\n",
       "      <td>3.324692</td>\n",
       "      <td>3.450374</td>\n",
       "      <td>...</td>\n",
       "      <td>3.123146</td>\n",
       "      <td>3.088256</td>\n",
       "      <td>3.188375</td>\n",
       "      <td>3.199688</td>\n",
       "      <td>3.321172</td>\n",
       "      <td>3.336882</td>\n",
       "      <td>3.188895</td>\n",
       "      <td>3.308299</td>\n",
       "      <td>3.352145</td>\n",
       "      <td>3.322545</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CFH</th>\n",
       "      <td>3.297096</td>\n",
       "      <td>3.382905</td>\n",
       "      <td>9.146877</td>\n",
       "      <td>5.133806</td>\n",
       "      <td>3.074383</td>\n",
       "      <td>3.107748</td>\n",
       "      <td>6.262654</td>\n",
       "      <td>3.300831</td>\n",
       "      <td>3.566350</td>\n",
       "      <td>3.723503</td>\n",
       "      <td>...</td>\n",
       "      <td>3.159148</td>\n",
       "      <td>7.497956</td>\n",
       "      <td>3.501447</td>\n",
       "      <td>5.233954</td>\n",
       "      <td>3.385376</td>\n",
       "      <td>3.357930</td>\n",
       "      <td>3.241747</td>\n",
       "      <td>5.719281</td>\n",
       "      <td>3.596993</td>\n",
       "      <td>5.631177</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FUCA2</th>\n",
       "      <td>7.914830</td>\n",
       "      <td>7.886826</td>\n",
       "      <td>7.800473</td>\n",
       "      <td>8.200329</td>\n",
       "      <td>7.290184</td>\n",
       "      <td>6.727436</td>\n",
       "      <td>8.160151</td>\n",
       "      <td>8.074968</td>\n",
       "      <td>8.204530</td>\n",
       "      <td>6.201861</td>\n",
       "      <td>...</td>\n",
       "      <td>8.743540</td>\n",
       "      <td>7.841270</td>\n",
       "      <td>8.180214</td>\n",
       "      <td>7.964240</td>\n",
       "      <td>7.662135</td>\n",
       "      <td>8.089836</td>\n",
       "      <td>7.563625</td>\n",
       "      <td>8.663654</td>\n",
       "      <td>7.196524</td>\n",
       "      <td>8.434965</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GCLC</th>\n",
       "      <td>8.366785</td>\n",
       "      <td>6.176860</td>\n",
       "      <td>7.921442</td>\n",
       "      <td>5.808631</td>\n",
       "      <td>6.322244</td>\n",
       "      <td>5.862634</td>\n",
       "      <td>5.726798</td>\n",
       "      <td>5.234662</td>\n",
       "      <td>5.235118</td>\n",
       "      <td>5.556517</td>\n",
       "      <td>...</td>\n",
       "      <td>5.842489</td>\n",
       "      <td>5.799141</td>\n",
       "      <td>6.820641</td>\n",
       "      <td>4.667093</td>\n",
       "      <td>5.906962</td>\n",
       "      <td>5.721922</td>\n",
       "      <td>4.767813</td>\n",
       "      <td>5.448271</td>\n",
       "      <td>5.519796</td>\n",
       "      <td>5.250324</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>NFYA</th>\n",
       "      <td>5.287493</td>\n",
       "      <td>5.373848</td>\n",
       "      <td>4.297621</td>\n",
       "      <td>4.880755</td>\n",
       "      <td>5.291903</td>\n",
       "      <td>5.337411</td>\n",
       "      <td>5.552501</td>\n",
       "      <td>4.348398</td>\n",
       "      <td>5.369039</td>\n",
       "      <td>5.508345</td>\n",
       "      <td>...</td>\n",
       "      <td>4.922979</td>\n",
       "      <td>5.585866</td>\n",
       "      <td>5.474809</td>\n",
       "      <td>4.926298</td>\n",
       "      <td>5.063413</td>\n",
       "      <td>4.795732</td>\n",
       "      <td>5.085422</td>\n",
       "      <td>5.058603</td>\n",
       "      <td>5.160911</td>\n",
       "      <td>4.947160</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>STPG1</th>\n",
       "      <td>3.564214</td>\n",
       "      <td>3.192959</td>\n",
       "      <td>3.433606</td>\n",
       "      <td>3.478922</td>\n",
       "      <td>3.342825</td>\n",
       "      <td>3.406295</td>\n",
       "      <td>3.157586</td>\n",
       "      <td>4.220588</td>\n",
       "      <td>3.596993</td>\n",
       "      <td>3.989457</td>\n",
       "      <td>...</td>\n",
       "      <td>3.564864</td>\n",
       "      <td>3.776654</td>\n",
       "      <td>3.665858</td>\n",
       "      <td>3.544039</td>\n",
       "      <td>3.818362</td>\n",
       "      <td>3.793957</td>\n",
       "      <td>3.827045</td>\n",
       "      <td>3.690896</td>\n",
       "      <td>3.383226</td>\n",
       "      <td>3.736243</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>NIPAL3</th>\n",
       "      <td>8.014412</td>\n",
       "      <td>6.474702</td>\n",
       "      <td>6.242772</td>\n",
       "      <td>6.287188</td>\n",
       "      <td>6.997999</td>\n",
       "      <td>5.788420</td>\n",
       "      <td>3.466931</td>\n",
       "      <td>8.421938</td>\n",
       "      <td>7.641756</td>\n",
       "      <td>6.385116</td>\n",
       "      <td>...</td>\n",
       "      <td>6.719300</td>\n",
       "      <td>6.968829</td>\n",
       "      <td>6.655483</td>\n",
       "      <td>7.562702</td>\n",
       "      <td>7.200407</td>\n",
       "      <td>6.550612</td>\n",
       "      <td>6.325523</td>\n",
       "      <td>6.475256</td>\n",
       "      <td>7.600511</td>\n",
       "      <td>7.167051</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>LAS1L</th>\n",
       "      <td>3.975528</td>\n",
       "      <td>4.290762</td>\n",
       "      <td>4.202653</td>\n",
       "      <td>3.983367</td>\n",
       "      <td>3.778874</td>\n",
       "      <td>4.685097</td>\n",
       "      <td>4.046791</td>\n",
       "      <td>3.834645</td>\n",
       "      <td>4.549065</td>\n",
       "      <td>4.042592</td>\n",
       "      <td>...</td>\n",
       "      <td>3.944367</td>\n",
       "      <td>3.782531</td>\n",
       "      <td>3.492792</td>\n",
       "      <td>4.144182</td>\n",
       "      <td>3.847817</td>\n",
       "      <td>4.226542</td>\n",
       "      <td>3.837344</td>\n",
       "      <td>4.344883</td>\n",
       "      <td>4.227789</td>\n",
       "      <td>4.822374</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ENPP4</th>\n",
       "      <td>5.187637</td>\n",
       "      <td>6.386638</td>\n",
       "      <td>3.445626</td>\n",
       "      <td>4.620981</td>\n",
       "      <td>3.105460</td>\n",
       "      <td>3.992244</td>\n",
       "      <td>4.621198</td>\n",
       "      <td>3.344071</td>\n",
       "      <td>4.488261</td>\n",
       "      <td>4.548210</td>\n",
       "      <td>...</td>\n",
       "      <td>5.787091</td>\n",
       "      <td>4.953234</td>\n",
       "      <td>5.436127</td>\n",
       "      <td>4.701149</td>\n",
       "      <td>4.561405</td>\n",
       "      <td>3.912650</td>\n",
       "      <td>5.333513</td>\n",
       "      <td>3.943886</td>\n",
       "      <td>4.305540</td>\n",
       "      <td>4.615197</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SEMA3F</th>\n",
       "      <td>3.764085</td>\n",
       "      <td>3.581448</td>\n",
       "      <td>4.111756</td>\n",
       "      <td>4.954450</td>\n",
       "      <td>4.366654</td>\n",
       "      <td>5.659382</td>\n",
       "      <td>4.582941</td>\n",
       "      <td>3.922672</td>\n",
       "      <td>4.118309</td>\n",
       "      <td>5.756912</td>\n",
       "      <td>...</td>\n",
       "      <td>4.218778</td>\n",
       "      <td>3.761762</td>\n",
       "      <td>4.302636</td>\n",
       "      <td>5.214318</td>\n",
       "      <td>4.518942</td>\n",
       "      <td>3.940632</td>\n",
       "      <td>4.958358</td>\n",
       "      <td>4.887619</td>\n",
       "      <td>4.157245</td>\n",
       "      <td>4.122925</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CFTR</th>\n",
       "      <td>3.088874</td>\n",
       "      <td>2.893617</td>\n",
       "      <td>3.008130</td>\n",
       "      <td>2.928328</td>\n",
       "      <td>3.017646</td>\n",
       "      <td>3.142844</td>\n",
       "      <td>3.038568</td>\n",
       "      <td>3.010235</td>\n",
       "      <td>3.024970</td>\n",
       "      <td>2.978755</td>\n",
       "      <td>...</td>\n",
       "      <td>2.941041</td>\n",
       "      <td>3.634551</td>\n",
       "      <td>7.188601</td>\n",
       "      <td>3.099811</td>\n",
       "      <td>3.246823</td>\n",
       "      <td>3.610002</td>\n",
       "      <td>2.765688</td>\n",
       "      <td>3.211279</td>\n",
       "      <td>3.463208</td>\n",
       "      <td>3.009863</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ANKIB1</th>\n",
       "      <td>8.901647</td>\n",
       "      <td>8.527974</td>\n",
       "      <td>8.208841</td>\n",
       "      <td>8.256953</td>\n",
       "      <td>7.682536</td>\n",
       "      <td>8.023329</td>\n",
       "      <td>8.147499</td>\n",
       "      <td>8.761885</td>\n",
       "      <td>8.296444</td>\n",
       "      <td>8.908791</td>\n",
       "      <td>...</td>\n",
       "      <td>8.591520</td>\n",
       "      <td>8.718188</td>\n",
       "      <td>7.981619</td>\n",
       "      <td>8.320088</td>\n",
       "      <td>7.900905</td>\n",
       "      <td>8.677345</td>\n",
       "      <td>7.973249</td>\n",
       "      <td>8.471688</td>\n",
       "      <td>7.732612</td>\n",
       "      <td>8.208733</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>KRIT1</th>\n",
       "      <td>3.833334</td>\n",
       "      <td>3.348572</td>\n",
       "      <td>3.781836</td>\n",
       "      <td>3.602513</td>\n",
       "      <td>3.492127</td>\n",
       "      <td>3.450652</td>\n",
       "      <td>3.598106</td>\n",
       "      <td>3.730710</td>\n",
       "      <td>3.646615</td>\n",
       "      <td>4.037117</td>\n",
       "      <td>...</td>\n",
       "      <td>3.540595</td>\n",
       "      <td>3.810870</td>\n",
       "      <td>4.137695</td>\n",
       "      <td>3.707591</td>\n",
       "      <td>3.693989</td>\n",
       "      <td>3.934370</td>\n",
       "      <td>3.573436</td>\n",
       "      <td>3.982073</td>\n",
       "      <td>3.889208</td>\n",
       "      <td>3.842057</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>RAD52</th>\n",
       "      <td>3.748139</td>\n",
       "      <td>3.193010</td>\n",
       "      <td>3.531233</td>\n",
       "      <td>3.528656</td>\n",
       "      <td>3.385511</td>\n",
       "      <td>3.603684</td>\n",
       "      <td>3.398061</td>\n",
       "      <td>3.420519</td>\n",
       "      <td>3.780467</td>\n",
       "      <td>3.541698</td>\n",
       "      <td>...</td>\n",
       "      <td>3.615865</td>\n",
       "      <td>3.379157</td>\n",
       "      <td>3.431033</td>\n",
       "      <td>3.332579</td>\n",
       "      <td>3.470023</td>\n",
       "      <td>3.220431</td>\n",
       "      <td>3.621764</td>\n",
       "      <td>4.626460</td>\n",
       "      <td>3.501948</td>\n",
       "      <td>3.420404</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BAD</th>\n",
       "      <td>7.290140</td>\n",
       "      <td>7.483544</td>\n",
       "      <td>6.596826</td>\n",
       "      <td>6.793032</td>\n",
       "      <td>6.675046</td>\n",
       "      <td>8.621570</td>\n",
       "      <td>7.119724</td>\n",
       "      <td>7.580534</td>\n",
       "      <td>7.458409</td>\n",
       "      <td>7.036707</td>\n",
       "      <td>...</td>\n",
       "      <td>6.010957</td>\n",
       "      <td>6.846846</td>\n",
       "      <td>6.961040</td>\n",
       "      <td>7.654143</td>\n",
       "      <td>7.738740</td>\n",
       "      <td>6.506791</td>\n",
       "      <td>7.462899</td>\n",
       "      <td>6.419810</td>\n",
       "      <td>9.196114</td>\n",
       "      <td>7.648273</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>LAP3</th>\n",
       "      <td>5.892368</td>\n",
       "      <td>7.098824</td>\n",
       "      <td>5.822783</td>\n",
       "      <td>7.197311</td>\n",
       "      <td>6.922605</td>\n",
       "      <td>5.190813</td>\n",
       "      <td>7.277089</td>\n",
       "      <td>6.664109</td>\n",
       "      <td>6.453926</td>\n",
       "      <td>7.003621</td>\n",
       "      <td>...</td>\n",
       "      <td>7.655741</td>\n",
       "      <td>8.062102</td>\n",
       "      <td>5.654547</td>\n",
       "      <td>6.684534</td>\n",
       "      <td>5.759920</td>\n",
       "      <td>5.541195</td>\n",
       "      <td>6.418024</td>\n",
       "      <td>6.238463</td>\n",
       "      <td>5.397888</td>\n",
       "      <td>6.133582</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CD99</th>\n",
       "      <td>7.418261</td>\n",
       "      <td>9.423980</td>\n",
       "      <td>8.878379</td>\n",
       "      <td>8.373799</td>\n",
       "      <td>8.670276</td>\n",
       "      <td>10.140090</td>\n",
       "      <td>8.750647</td>\n",
       "      <td>10.229438</td>\n",
       "      <td>9.460478</td>\n",
       "      <td>8.966939</td>\n",
       "      <td>...</td>\n",
       "      <td>5.731270</td>\n",
       "      <td>6.928679</td>\n",
       "      <td>8.992775</td>\n",
       "      <td>9.691453</td>\n",
       "      <td>7.951767</td>\n",
       "      <td>8.323406</td>\n",
       "      <td>9.198415</td>\n",
       "      <td>8.016087</td>\n",
       "      <td>8.697365</td>\n",
       "      <td>8.166390</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HS3ST1</th>\n",
       "      <td>3.076180</td>\n",
       "      <td>3.796722</td>\n",
       "      <td>3.736890</td>\n",
       "      <td>6.745770</td>\n",
       "      <td>3.859489</td>\n",
       "      <td>3.336679</td>\n",
       "      <td>4.101128</td>\n",
       "      <td>3.482057</td>\n",
       "      <td>3.517445</td>\n",
       "      <td>3.378110</td>\n",
       "      <td>...</td>\n",
       "      <td>4.521515</td>\n",
       "      <td>5.857313</td>\n",
       "      <td>4.274328</td>\n",
       "      <td>3.632953</td>\n",
       "      <td>3.069348</td>\n",
       "      <td>3.183156</td>\n",
       "      <td>3.936523</td>\n",
       "      <td>3.063334</td>\n",
       "      <td>3.341049</td>\n",
       "      <td>5.959631</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ABP1</th>\n",
       "      <td>3.643995</td>\n",
       "      <td>3.289749</td>\n",
       "      <td>3.306772</td>\n",
       "      <td>3.290169</td>\n",
       "      <td>3.361698</td>\n",
       "      <td>3.577479</td>\n",
       "      <td>3.213673</td>\n",
       "      <td>3.485379</td>\n",
       "      <td>3.350498</td>\n",
       "      <td>3.597797</td>\n",
       "      <td>...</td>\n",
       "      <td>6.195352</td>\n",
       "      <td>3.325421</td>\n",
       "      <td>7.850185</td>\n",
       "      <td>3.473305</td>\n",
       "      <td>3.263429</td>\n",
       "      <td>3.224062</td>\n",
       "      <td>3.441179</td>\n",
       "      <td>3.423523</td>\n",
       "      <td>3.294335</td>\n",
       "      <td>3.229629</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>WNT16</th>\n",
       "      <td>2.730148</td>\n",
       "      <td>2.902667</td>\n",
       "      <td>2.935304</td>\n",
       "      <td>3.189503</td>\n",
       "      <td>2.835848</td>\n",
       "      <td>3.036598</td>\n",
       "      <td>2.843903</td>\n",
       "      <td>2.832047</td>\n",
       "      <td>3.741032</td>\n",
       "      <td>2.846700</td>\n",
       "      <td>...</td>\n",
       "      <td>2.852783</td>\n",
       "      <td>2.853366</td>\n",
       "      <td>2.812539</td>\n",
       "      <td>2.888368</td>\n",
       "      <td>2.910818</td>\n",
       "      <td>2.921735</td>\n",
       "      <td>2.761468</td>\n",
       "      <td>2.940464</td>\n",
       "      <td>2.937517</td>\n",
       "      <td>3.461068</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HECW1</th>\n",
       "      <td>3.075611</td>\n",
       "      <td>2.674371</td>\n",
       "      <td>3.246909</td>\n",
       "      <td>3.001303</td>\n",
       "      <td>2.778510</td>\n",
       "      <td>2.812926</td>\n",
       "      <td>3.046672</td>\n",
       "      <td>2.669112</td>\n",
       "      <td>2.661393</td>\n",
       "      <td>3.047161</td>\n",
       "      <td>...</td>\n",
       "      <td>2.855329</td>\n",
       "      <td>2.849081</td>\n",
       "      <td>2.677311</td>\n",
       "      <td>2.829970</td>\n",
       "      <td>2.821788</td>\n",
       "      <td>2.752960</td>\n",
       "      <td>2.920763</td>\n",
       "      <td>2.937170</td>\n",
       "      <td>2.938455</td>\n",
       "      <td>2.838418</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MAD1L1</th>\n",
       "      <td>5.485238</td>\n",
       "      <td>5.682445</td>\n",
       "      <td>4.111315</td>\n",
       "      <td>5.325992</td>\n",
       "      <td>5.161292</td>\n",
       "      <td>6.486319</td>\n",
       "      <td>7.153442</td>\n",
       "      <td>9.474093</td>\n",
       "      <td>5.200431</td>\n",
       "      <td>5.371834</td>\n",
       "      <td>...</td>\n",
       "      <td>5.503556</td>\n",
       "      <td>4.679315</td>\n",
       "      <td>7.683906</td>\n",
       "      <td>6.269770</td>\n",
       "      <td>4.958479</td>\n",
       "      <td>5.003898</td>\n",
       "      <td>6.214460</td>\n",
       "      <td>4.335608</td>\n",
       "      <td>4.531748</td>\n",
       "      <td>5.809043</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>LASP1</th>\n",
       "      <td>4.530159</td>\n",
       "      <td>4.723579</td>\n",
       "      <td>4.591571</td>\n",
       "      <td>4.293141</td>\n",
       "      <td>4.750941</td>\n",
       "      <td>6.424801</td>\n",
       "      <td>3.998433</td>\n",
       "      <td>4.203288</td>\n",
       "      <td>4.931681</td>\n",
       "      <td>4.208903</td>\n",
       "      <td>...</td>\n",
       "      <td>4.420156</td>\n",
       "      <td>4.291471</td>\n",
       "      <td>4.572707</td>\n",
       "      <td>4.829535</td>\n",
       "      <td>4.126406</td>\n",
       "      <td>4.667485</td>\n",
       "      <td>5.741565</td>\n",
       "      <td>4.005830</td>\n",
       "      <td>4.005251</td>\n",
       "      <td>4.455299</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SNX11</th>\n",
       "      <td>4.696593</td>\n",
       "      <td>4.971820</td>\n",
       "      <td>5.035484</td>\n",
       "      <td>4.739336</td>\n",
       "      <td>5.046363</td>\n",
       "      <td>4.874689</td>\n",
       "      <td>4.611066</td>\n",
       "      <td>5.218077</td>\n",
       "      <td>4.767457</td>\n",
       "      <td>5.402698</td>\n",
       "      <td>...</td>\n",
       "      <td>5.030809</td>\n",
       "      <td>5.025006</td>\n",
       "      <td>4.762145</td>\n",
       "      <td>5.069310</td>\n",
       "      <td>5.187392</td>\n",
       "      <td>5.241098</td>\n",
       "      <td>4.646291</td>\n",
       "      <td>4.546235</td>\n",
       "      <td>4.555568</td>\n",
       "      <td>4.879591</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TMEM176A</th>\n",
       "      <td>3.543446</td>\n",
       "      <td>2.921362</td>\n",
       "      <td>3.448695</td>\n",
       "      <td>3.401791</td>\n",
       "      <td>3.409411</td>\n",
       "      <td>3.349065</td>\n",
       "      <td>3.305873</td>\n",
       "      <td>3.076385</td>\n",
       "      <td>2.975821</td>\n",
       "      <td>3.429175</td>\n",
       "      <td>...</td>\n",
       "      <td>5.620342</td>\n",
       "      <td>3.037889</td>\n",
       "      <td>6.241351</td>\n",
       "      <td>3.115563</td>\n",
       "      <td>3.555581</td>\n",
       "      <td>3.193063</td>\n",
       "      <td>5.646760</td>\n",
       "      <td>3.243171</td>\n",
       "      <td>3.536854</td>\n",
       "      <td>3.650592</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PRSS58</th>\n",
       "      <td>2.913732</td>\n",
       "      <td>2.957712</td>\n",
       "      <td>2.908623</td>\n",
       "      <td>2.913220</td>\n",
       "      <td>2.924590</td>\n",
       "      <td>2.805834</td>\n",
       "      <td>2.829585</td>\n",
       "      <td>2.818304</td>\n",
       "      <td>3.043992</td>\n",
       "      <td>3.327380</td>\n",
       "      <td>...</td>\n",
       "      <td>2.821643</td>\n",
       "      <td>2.786863</td>\n",
       "      <td>2.985265</td>\n",
       "      <td>2.845151</td>\n",
       "      <td>2.881435</td>\n",
       "      <td>3.747818</td>\n",
       "      <td>2.822185</td>\n",
       "      <td>2.813012</td>\n",
       "      <td>2.865009</td>\n",
       "      <td>2.827539</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CLEC5A</th>\n",
       "      <td>2.882885</td>\n",
       "      <td>2.907286</td>\n",
       "      <td>2.859608</td>\n",
       "      <td>2.907639</td>\n",
       "      <td>2.871217</td>\n",
       "      <td>2.863003</td>\n",
       "      <td>2.913607</td>\n",
       "      <td>2.875075</td>\n",
       "      <td>2.765216</td>\n",
       "      <td>2.938255</td>\n",
       "      <td>...</td>\n",
       "      <td>2.936267</td>\n",
       "      <td>2.873464</td>\n",
       "      <td>3.094612</td>\n",
       "      <td>2.827086</td>\n",
       "      <td>2.987454</td>\n",
       "      <td>2.780661</td>\n",
       "      <td>2.898078</td>\n",
       "      <td>2.974589</td>\n",
       "      <td>2.936993</td>\n",
       "      <td>2.934071</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ZNF578</th>\n",
       "      <td>2.827134</td>\n",
       "      <td>2.716170</td>\n",
       "      <td>2.870628</td>\n",
       "      <td>2.653077</td>\n",
       "      <td>2.901043</td>\n",
       "      <td>2.674094</td>\n",
       "      <td>2.881317</td>\n",
       "      <td>2.669786</td>\n",
       "      <td>2.850649</td>\n",
       "      <td>2.759052</td>\n",
       "      <td>...</td>\n",
       "      <td>2.872329</td>\n",
       "      <td>2.818878</td>\n",
       "      <td>2.734593</td>\n",
       "      <td>2.742695</td>\n",
       "      <td>2.947602</td>\n",
       "      <td>2.824600</td>\n",
       "      <td>2.714856</td>\n",
       "      <td>2.805740</td>\n",
       "      <td>2.872519</td>\n",
       "      <td>2.846660</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>DIO3OS</th>\n",
       "      <td>3.498152</td>\n",
       "      <td>3.134175</td>\n",
       "      <td>3.624569</td>\n",
       "      <td>3.428026</td>\n",
       "      <td>3.505836</td>\n",
       "      <td>3.442485</td>\n",
       "      <td>3.692914</td>\n",
       "      <td>3.455929</td>\n",
       "      <td>3.310295</td>\n",
       "      <td>3.623235</td>\n",
       "      <td>...</td>\n",
       "      <td>3.459257</td>\n",
       "      <td>3.473977</td>\n",
       "      <td>3.556191</td>\n",
       "      <td>3.380172</td>\n",
       "      <td>3.588807</td>\n",
       "      <td>3.509469</td>\n",
       "      <td>3.618053</td>\n",
       "      <td>3.619355</td>\n",
       "      <td>4.239149</td>\n",
       "      <td>3.595024</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>UBE2CP1</th>\n",
       "      <td>9.102221</td>\n",
       "      <td>10.947940</td>\n",
       "      <td>9.170254</td>\n",
       "      <td>10.503122</td>\n",
       "      <td>11.328646</td>\n",
       "      <td>11.008080</td>\n",
       "      <td>11.159289</td>\n",
       "      <td>10.241567</td>\n",
       "      <td>10.941187</td>\n",
       "      <td>9.382099</td>\n",
       "      <td>...</td>\n",
       "      <td>10.135301</td>\n",
       "      <td>10.495289</td>\n",
       "      <td>10.749901</td>\n",
       "      <td>11.221197</td>\n",
       "      <td>11.233535</td>\n",
       "      <td>10.899278</td>\n",
       "      <td>9.046075</td>\n",
       "      <td>11.554995</td>\n",
       "      <td>9.876791</td>\n",
       "      <td>11.661603</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>LINC00638</th>\n",
       "      <td>2.973991</td>\n",
       "      <td>3.357499</td>\n",
       "      <td>3.293073</td>\n",
       "      <td>3.479271</td>\n",
       "      <td>3.595077</td>\n",
       "      <td>3.550282</td>\n",
       "      <td>3.423951</td>\n",
       "      <td>3.550613</td>\n",
       "      <td>3.214615</td>\n",
       "      <td>3.697266</td>\n",
       "      <td>...</td>\n",
       "      <td>3.625674</td>\n",
       "      <td>3.212535</td>\n",
       "      <td>3.601367</td>\n",
       "      <td>3.467733</td>\n",
       "      <td>3.573795</td>\n",
       "      <td>3.424304</td>\n",
       "      <td>3.404818</td>\n",
       "      <td>3.354366</td>\n",
       "      <td>3.550056</td>\n",
       "      <td>3.372026</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>OR4C13</th>\n",
       "      <td>2.910828</td>\n",
       "      <td>3.029896</td>\n",
       "      <td>2.950666</td>\n",
       "      <td>2.865286</td>\n",
       "      <td>2.845514</td>\n",
       "      <td>2.600062</td>\n",
       "      <td>2.925456</td>\n",
       "      <td>3.107405</td>\n",
       "      <td>2.654211</td>\n",
       "      <td>3.452664</td>\n",
       "      <td>...</td>\n",
       "      <td>2.956142</td>\n",
       "      <td>2.825633</td>\n",
       "      <td>3.085107</td>\n",
       "      <td>2.988314</td>\n",
       "      <td>3.057237</td>\n",
       "      <td>2.926035</td>\n",
       "      <td>2.847841</td>\n",
       "      <td>3.019718</td>\n",
       "      <td>2.639676</td>\n",
       "      <td>2.934086</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CEP95</th>\n",
       "      <td>6.468250</td>\n",
       "      <td>6.105404</td>\n",
       "      <td>6.787414</td>\n",
       "      <td>6.996554</td>\n",
       "      <td>6.494273</td>\n",
       "      <td>6.969322</td>\n",
       "      <td>6.243260</td>\n",
       "      <td>6.026007</td>\n",
       "      <td>6.026643</td>\n",
       "      <td>7.178561</td>\n",
       "      <td>...</td>\n",
       "      <td>7.288748</td>\n",
       "      <td>6.732115</td>\n",
       "      <td>7.239201</td>\n",
       "      <td>6.688247</td>\n",
       "      <td>6.924229</td>\n",
       "      <td>6.268029</td>\n",
       "      <td>6.828407</td>\n",
       "      <td>6.172780</td>\n",
       "      <td>6.577474</td>\n",
       "      <td>6.624370</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SMIM6</th>\n",
       "      <td>3.608694</td>\n",
       "      <td>3.509509</td>\n",
       "      <td>7.677502</td>\n",
       "      <td>3.124435</td>\n",
       "      <td>3.583158</td>\n",
       "      <td>3.289929</td>\n",
       "      <td>3.499269</td>\n",
       "      <td>3.088285</td>\n",
       "      <td>3.500628</td>\n",
       "      <td>3.559782</td>\n",
       "      <td>...</td>\n",
       "      <td>6.740510</td>\n",
       "      <td>3.609881</td>\n",
       "      <td>6.135534</td>\n",
       "      <td>3.544795</td>\n",
       "      <td>3.699950</td>\n",
       "      <td>3.435613</td>\n",
       "      <td>3.377913</td>\n",
       "      <td>3.647021</td>\n",
       "      <td>4.108694</td>\n",
       "      <td>3.694118</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SLC35G6</th>\n",
       "      <td>2.946378</td>\n",
       "      <td>3.525515</td>\n",
       "      <td>3.201922</td>\n",
       "      <td>3.207881</td>\n",
       "      <td>3.080393</td>\n",
       "      <td>3.327731</td>\n",
       "      <td>3.112586</td>\n",
       "      <td>3.391988</td>\n",
       "      <td>2.949881</td>\n",
       "      <td>3.500728</td>\n",
       "      <td>...</td>\n",
       "      <td>3.375379</td>\n",
       "      <td>3.000302</td>\n",
       "      <td>3.770793</td>\n",
       "      <td>2.997961</td>\n",
       "      <td>3.066558</td>\n",
       "      <td>2.963289</td>\n",
       "      <td>3.310942</td>\n",
       "      <td>3.187519</td>\n",
       "      <td>3.155445</td>\n",
       "      <td>3.583261</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>LINC00596</th>\n",
       "      <td>3.184840</td>\n",
       "      <td>3.065742</td>\n",
       "      <td>2.869266</td>\n",
       "      <td>2.969559</td>\n",
       "      <td>3.009178</td>\n",
       "      <td>3.108361</td>\n",
       "      <td>3.347198</td>\n",
       "      <td>3.109302</td>\n",
       "      <td>2.965231</td>\n",
       "      <td>3.102900</td>\n",
       "      <td>...</td>\n",
       "      <td>2.926848</td>\n",
       "      <td>3.075315</td>\n",
       "      <td>3.201215</td>\n",
       "      <td>3.114260</td>\n",
       "      <td>2.945957</td>\n",
       "      <td>3.189769</td>\n",
       "      <td>2.722790</td>\n",
       "      <td>2.984552</td>\n",
       "      <td>3.216597</td>\n",
       "      <td>3.073545</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>OR4N3P</th>\n",
       "      <td>2.931340</td>\n",
       "      <td>2.792758</td>\n",
       "      <td>3.499758</td>\n",
       "      <td>3.128158</td>\n",
       "      <td>5.826540</td>\n",
       "      <td>3.263766</td>\n",
       "      <td>3.493448</td>\n",
       "      <td>3.000699</td>\n",
       "      <td>3.070104</td>\n",
       "      <td>3.472764</td>\n",
       "      <td>...</td>\n",
       "      <td>3.668672</td>\n",
       "      <td>3.098503</td>\n",
       "      <td>3.994643</td>\n",
       "      <td>3.494848</td>\n",
       "      <td>3.243701</td>\n",
       "      <td>3.327722</td>\n",
       "      <td>2.904468</td>\n",
       "      <td>3.419681</td>\n",
       "      <td>3.349971</td>\n",
       "      <td>3.122308</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MRPL46</th>\n",
       "      <td>8.220662</td>\n",
       "      <td>8.078510</td>\n",
       "      <td>8.766834</td>\n",
       "      <td>8.663546</td>\n",
       "      <td>8.826113</td>\n",
       "      <td>8.603450</td>\n",
       "      <td>7.545215</td>\n",
       "      <td>7.865144</td>\n",
       "      <td>7.754133</td>\n",
       "      <td>8.194615</td>\n",
       "      <td>...</td>\n",
       "      <td>8.436344</td>\n",
       "      <td>8.429868</td>\n",
       "      <td>8.878589</td>\n",
       "      <td>8.427807</td>\n",
       "      <td>8.668263</td>\n",
       "      <td>8.151076</td>\n",
       "      <td>8.339814</td>\n",
       "      <td>7.788280</td>\n",
       "      <td>8.818152</td>\n",
       "      <td>8.983863</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>C15orf37</th>\n",
       "      <td>2.957060</td>\n",
       "      <td>3.019703</td>\n",
       "      <td>3.156294</td>\n",
       "      <td>3.105757</td>\n",
       "      <td>3.280863</td>\n",
       "      <td>3.058039</td>\n",
       "      <td>3.078014</td>\n",
       "      <td>3.149327</td>\n",
       "      <td>3.080081</td>\n",
       "      <td>3.597679</td>\n",
       "      <td>...</td>\n",
       "      <td>2.875045</td>\n",
       "      <td>3.158818</td>\n",
       "      <td>3.139445</td>\n",
       "      <td>3.135205</td>\n",
       "      <td>3.941021</td>\n",
       "      <td>2.812329</td>\n",
       "      <td>3.191560</td>\n",
       "      <td>3.155568</td>\n",
       "      <td>2.967439</td>\n",
       "      <td>3.102254</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SH3RF3-AS1</th>\n",
       "      <td>3.572554</td>\n",
       "      <td>3.388511</td>\n",
       "      <td>3.307052</td>\n",
       "      <td>3.298423</td>\n",
       "      <td>3.342639</td>\n",
       "      <td>3.495746</td>\n",
       "      <td>3.387211</td>\n",
       "      <td>3.674423</td>\n",
       "      <td>3.440519</td>\n",
       "      <td>3.889395</td>\n",
       "      <td>...</td>\n",
       "      <td>3.493689</td>\n",
       "      <td>3.264042</td>\n",
       "      <td>3.626219</td>\n",
       "      <td>3.219390</td>\n",
       "      <td>3.338095</td>\n",
       "      <td>3.452632</td>\n",
       "      <td>3.657555</td>\n",
       "      <td>3.363031</td>\n",
       "      <td>3.227857</td>\n",
       "      <td>3.295718</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>LINC00657</th>\n",
       "      <td>9.472126</td>\n",
       "      <td>9.748871</td>\n",
       "      <td>9.491885</td>\n",
       "      <td>9.181071</td>\n",
       "      <td>9.947403</td>\n",
       "      <td>9.576864</td>\n",
       "      <td>8.787367</td>\n",
       "      <td>8.586205</td>\n",
       "      <td>9.622136</td>\n",
       "      <td>9.116460</td>\n",
       "      <td>...</td>\n",
       "      <td>9.864919</td>\n",
       "      <td>8.882914</td>\n",
       "      <td>9.281960</td>\n",
       "      <td>9.530058</td>\n",
       "      <td>9.048254</td>\n",
       "      <td>8.798876</td>\n",
       "      <td>9.218044</td>\n",
       "      <td>8.349385</td>\n",
       "      <td>8.840221</td>\n",
       "      <td>8.886559</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MOCS1P1</th>\n",
       "      <td>3.902595</td>\n",
       "      <td>3.221467</td>\n",
       "      <td>3.683660</td>\n",
       "      <td>3.539041</td>\n",
       "      <td>3.489571</td>\n",
       "      <td>3.479204</td>\n",
       "      <td>3.618551</td>\n",
       "      <td>3.145488</td>\n",
       "      <td>3.183110</td>\n",
       "      <td>3.130554</td>\n",
       "      <td>...</td>\n",
       "      <td>3.382850</td>\n",
       "      <td>3.255666</td>\n",
       "      <td>3.540850</td>\n",
       "      <td>3.172379</td>\n",
       "      <td>3.431699</td>\n",
       "      <td>3.914902</td>\n",
       "      <td>3.975558</td>\n",
       "      <td>3.665399</td>\n",
       "      <td>4.382022</td>\n",
       "      <td>3.913042</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GOLGA6L7P</th>\n",
       "      <td>3.649731</td>\n",
       "      <td>3.503329</td>\n",
       "      <td>3.866463</td>\n",
       "      <td>3.881780</td>\n",
       "      <td>3.527467</td>\n",
       "      <td>3.744933</td>\n",
       "      <td>3.634084</td>\n",
       "      <td>3.802010</td>\n",
       "      <td>3.529562</td>\n",
       "      <td>4.026188</td>\n",
       "      <td>...</td>\n",
       "      <td>3.970129</td>\n",
       "      <td>4.108772</td>\n",
       "      <td>4.565392</td>\n",
       "      <td>4.323577</td>\n",
       "      <td>4.143307</td>\n",
       "      <td>3.454142</td>\n",
       "      <td>3.391522</td>\n",
       "      <td>3.760134</td>\n",
       "      <td>4.535952</td>\n",
       "      <td>3.916097</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>HPR</th>\n",
       "      <td>2.790603</td>\n",
       "      <td>2.853155</td>\n",
       "      <td>2.947796</td>\n",
       "      <td>2.911892</td>\n",
       "      <td>3.017686</td>\n",
       "      <td>2.785442</td>\n",
       "      <td>2.603039</td>\n",
       "      <td>2.841387</td>\n",
       "      <td>2.790461</td>\n",
       "      <td>3.105338</td>\n",
       "      <td>...</td>\n",
       "      <td>2.630562</td>\n",
       "      <td>2.744761</td>\n",
       "      <td>2.766801</td>\n",
       "      <td>2.819483</td>\n",
       "      <td>2.813953</td>\n",
       "      <td>2.709272</td>\n",
       "      <td>2.884169</td>\n",
       "      <td>2.726429</td>\n",
       "      <td>2.811859</td>\n",
       "      <td>2.776810</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MIA</th>\n",
       "      <td>3.439633</td>\n",
       "      <td>3.459250</td>\n",
       "      <td>3.680356</td>\n",
       "      <td>3.685443</td>\n",
       "      <td>3.591036</td>\n",
       "      <td>3.898051</td>\n",
       "      <td>4.082301</td>\n",
       "      <td>9.887219</td>\n",
       "      <td>3.588889</td>\n",
       "      <td>3.977683</td>\n",
       "      <td>...</td>\n",
       "      <td>3.788622</td>\n",
       "      <td>3.772547</td>\n",
       "      <td>4.178984</td>\n",
       "      <td>3.706254</td>\n",
       "      <td>4.039565</td>\n",
       "      <td>3.671843</td>\n",
       "      <td>4.213348</td>\n",
       "      <td>3.780613</td>\n",
       "      <td>3.688854</td>\n",
       "      <td>3.802038</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>LINC00514</th>\n",
       "      <td>3.264254</td>\n",
       "      <td>3.314727</td>\n",
       "      <td>3.169682</td>\n",
       "      <td>4.254346</td>\n",
       "      <td>4.631837</td>\n",
       "      <td>8.683069</td>\n",
       "      <td>3.047456</td>\n",
       "      <td>3.336458</td>\n",
       "      <td>3.665788</td>\n",
       "      <td>3.537723</td>\n",
       "      <td>...</td>\n",
       "      <td>9.300587</td>\n",
       "      <td>3.283884</td>\n",
       "      <td>3.148844</td>\n",
       "      <td>3.205160</td>\n",
       "      <td>3.164661</td>\n",
       "      <td>3.244645</td>\n",
       "      <td>3.377764</td>\n",
       "      <td>3.463670</td>\n",
       "      <td>3.277527</td>\n",
       "      <td>3.211911</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>OR1D5</th>\n",
       "      <td>3.201629</td>\n",
       "      <td>3.569253</td>\n",
       "      <td>3.923083</td>\n",
       "      <td>3.736702</td>\n",
       "      <td>3.396205</td>\n",
       "      <td>3.729224</td>\n",
       "      <td>3.076234</td>\n",
       "      <td>3.269096</td>\n",
       "      <td>3.134197</td>\n",
       "      <td>3.996887</td>\n",
       "      <td>...</td>\n",
       "      <td>3.952035</td>\n",
       "      <td>3.592234</td>\n",
       "      <td>3.892404</td>\n",
       "      <td>4.722517</td>\n",
       "      <td>4.068742</td>\n",
       "      <td>3.129759</td>\n",
       "      <td>3.285953</td>\n",
       "      <td>3.666239</td>\n",
       "      <td>3.221485</td>\n",
       "      <td>3.992597</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ZNF234</th>\n",
       "      <td>3.878922</td>\n",
       "      <td>4.361398</td>\n",
       "      <td>4.535106</td>\n",
       "      <td>3.903117</td>\n",
       "      <td>4.675023</td>\n",
       "      <td>4.335110</td>\n",
       "      <td>4.386448</td>\n",
       "      <td>4.477071</td>\n",
       "      <td>4.841169</td>\n",
       "      <td>4.247065</td>\n",
       "      <td>...</td>\n",
       "      <td>4.299596</td>\n",
       "      <td>3.901565</td>\n",
       "      <td>4.136612</td>\n",
       "      <td>4.058997</td>\n",
       "      <td>4.372890</td>\n",
       "      <td>4.238990</td>\n",
       "      <td>4.309004</td>\n",
       "      <td>4.830290</td>\n",
       "      <td>4.618169</td>\n",
       "      <td>4.389972</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MYH4</th>\n",
       "      <td>2.745669</td>\n",
       "      <td>2.459203</td>\n",
       "      <td>2.611597</td>\n",
       "      <td>2.718814</td>\n",
       "      <td>2.586323</td>\n",
       "      <td>2.497412</td>\n",
       "      <td>2.566644</td>\n",
       "      <td>2.644848</td>\n",
       "      <td>2.628932</td>\n",
       "      <td>2.654267</td>\n",
       "      <td>...</td>\n",
       "      <td>2.420469</td>\n",
       "      <td>2.580622</td>\n",
       "      <td>3.745408</td>\n",
       "      <td>2.542529</td>\n",
       "      <td>2.526370</td>\n",
       "      <td>2.468235</td>\n",
       "      <td>2.592263</td>\n",
       "      <td>2.634019</td>\n",
       "      <td>2.617327</td>\n",
       "      <td>2.651644</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>LINC00526</th>\n",
       "      <td>5.102353</td>\n",
       "      <td>4.874740</td>\n",
       "      <td>4.504059</td>\n",
       "      <td>4.950010</td>\n",
       "      <td>5.532821</td>\n",
       "      <td>3.100561</td>\n",
       "      <td>3.753303</td>\n",
       "      <td>3.797210</td>\n",
       "      <td>6.786925</td>\n",
       "      <td>3.973798</td>\n",
       "      <td>...</td>\n",
       "      <td>4.479077</td>\n",
       "      <td>5.170182</td>\n",
       "      <td>5.996199</td>\n",
       "      <td>4.105723</td>\n",
       "      <td>4.234477</td>\n",
       "      <td>5.248192</td>\n",
       "      <td>4.471384</td>\n",
       "      <td>5.422379</td>\n",
       "      <td>3.496213</td>\n",
       "      <td>4.058739</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PPY2</th>\n",
       "      <td>3.080394</td>\n",
       "      <td>3.233059</td>\n",
       "      <td>3.036383</td>\n",
       "      <td>2.970800</td>\n",
       "      <td>2.991137</td>\n",
       "      <td>3.040448</td>\n",
       "      <td>3.144031</td>\n",
       "      <td>3.069556</td>\n",
       "      <td>2.997054</td>\n",
       "      <td>3.361569</td>\n",
       "      <td>...</td>\n",
       "      <td>3.219672</td>\n",
       "      <td>3.226851</td>\n",
       "      <td>3.311019</td>\n",
       "      <td>3.190357</td>\n",
       "      <td>3.295970</td>\n",
       "      <td>3.244465</td>\n",
       "      <td>3.135298</td>\n",
       "      <td>3.407639</td>\n",
       "      <td>3.299581</td>\n",
       "      <td>3.109451</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>KRT18P55</th>\n",
       "      <td>3.378913</td>\n",
       "      <td>3.648132</td>\n",
       "      <td>3.259655</td>\n",
       "      <td>3.386533</td>\n",
       "      <td>3.554597</td>\n",
       "      <td>3.136316</td>\n",
       "      <td>3.083726</td>\n",
       "      <td>3.062048</td>\n",
       "      <td>3.331134</td>\n",
       "      <td>3.413643</td>\n",
       "      <td>...</td>\n",
       "      <td>3.012350</td>\n",
       "      <td>3.161274</td>\n",
       "      <td>3.344123</td>\n",
       "      <td>3.785186</td>\n",
       "      <td>3.082722</td>\n",
       "      <td>3.045701</td>\n",
       "      <td>3.735873</td>\n",
       "      <td>3.385810</td>\n",
       "      <td>3.335831</td>\n",
       "      <td>3.589427</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>POLRMTP1</th>\n",
       "      <td>3.191797</td>\n",
       "      <td>3.022160</td>\n",
       "      <td>2.934753</td>\n",
       "      <td>2.931548</td>\n",
       "      <td>3.168497</td>\n",
       "      <td>3.024960</td>\n",
       "      <td>3.406266</td>\n",
       "      <td>3.185092</td>\n",
       "      <td>3.130696</td>\n",
       "      <td>3.375437</td>\n",
       "      <td>...</td>\n",
       "      <td>2.837757</td>\n",
       "      <td>2.829626</td>\n",
       "      <td>3.079624</td>\n",
       "      <td>3.078025</td>\n",
       "      <td>2.995339</td>\n",
       "      <td>3.057605</td>\n",
       "      <td>2.853571</td>\n",
       "      <td>3.321254</td>\n",
       "      <td>3.386745</td>\n",
       "      <td>3.469339</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>UBL5P2</th>\n",
       "      <td>9.466545</td>\n",
       "      <td>9.267838</td>\n",
       "      <td>9.174437</td>\n",
       "      <td>9.781957</td>\n",
       "      <td>9.235654</td>\n",
       "      <td>9.594467</td>\n",
       "      <td>9.333854</td>\n",
       "      <td>9.839337</td>\n",
       "      <td>9.986616</td>\n",
       "      <td>9.450962</td>\n",
       "      <td>...</td>\n",
       "      <td>8.125303</td>\n",
       "      <td>9.471560</td>\n",
       "      <td>9.272901</td>\n",
       "      <td>9.385839</td>\n",
       "      <td>9.217796</td>\n",
       "      <td>9.246567</td>\n",
       "      <td>9.616495</td>\n",
       "      <td>8.601714</td>\n",
       "      <td>8.319282</td>\n",
       "      <td>9.270088</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TBC1D3P5</th>\n",
       "      <td>3.214997</td>\n",
       "      <td>3.340621</td>\n",
       "      <td>3.450427</td>\n",
       "      <td>3.052209</td>\n",
       "      <td>3.299910</td>\n",
       "      <td>3.340264</td>\n",
       "      <td>3.438851</td>\n",
       "      <td>3.207780</td>\n",
       "      <td>3.073724</td>\n",
       "      <td>3.581946</td>\n",
       "      <td>...</td>\n",
       "      <td>3.198928</td>\n",
       "      <td>3.192203</td>\n",
       "      <td>3.525726</td>\n",
       "      <td>3.350846</td>\n",
       "      <td>3.437583</td>\n",
       "      <td>3.247812</td>\n",
       "      <td>3.523841</td>\n",
       "      <td>3.519523</td>\n",
       "      <td>3.364994</td>\n",
       "      <td>3.445858</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>17419 rows × 83 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                22RV1      647-V      A549   BFTC-905      BT-20     BT-474  \\\n",
       "TSPAN6       4.804487   8.713556  8.495961   7.813436   7.971621   5.178131   \n",
       "TNMD         2.848128   2.834723  2.886997   2.879330   2.792528   3.015506   \n",
       "DPM1        10.331994  10.504748  9.643436  10.272719  10.601207  10.548792   \n",
       "SCYL3        5.145387   3.792188  4.154471   4.050385   5.622674   5.829252   \n",
       "C1orf112     3.545193   3.946664  3.307310   3.701491   3.740521   3.800657   \n",
       "FGR          2.981772   3.106757  3.132815   3.036505   3.377295   3.446415   \n",
       "CFH          3.297096   3.382905  9.146877   5.133806   3.074383   3.107748   \n",
       "FUCA2        7.914830   7.886826  7.800473   8.200329   7.290184   6.727436   \n",
       "GCLC         8.366785   6.176860  7.921442   5.808631   6.322244   5.862634   \n",
       "NFYA         5.287493   5.373848  4.297621   4.880755   5.291903   5.337411   \n",
       "STPG1        3.564214   3.192959  3.433606   3.478922   3.342825   3.406295   \n",
       "NIPAL3       8.014412   6.474702  6.242772   6.287188   6.997999   5.788420   \n",
       "LAS1L        3.975528   4.290762  4.202653   3.983367   3.778874   4.685097   \n",
       "ENPP4        5.187637   6.386638  3.445626   4.620981   3.105460   3.992244   \n",
       "SEMA3F       3.764085   3.581448  4.111756   4.954450   4.366654   5.659382   \n",
       "CFTR         3.088874   2.893617  3.008130   2.928328   3.017646   3.142844   \n",
       "ANKIB1       8.901647   8.527974  8.208841   8.256953   7.682536   8.023329   \n",
       "KRIT1        3.833334   3.348572  3.781836   3.602513   3.492127   3.450652   \n",
       "RAD52        3.748139   3.193010  3.531233   3.528656   3.385511   3.603684   \n",
       "BAD          7.290140   7.483544  6.596826   6.793032   6.675046   8.621570   \n",
       "LAP3         5.892368   7.098824  5.822783   7.197311   6.922605   5.190813   \n",
       "CD99         7.418261   9.423980  8.878379   8.373799   8.670276  10.140090   \n",
       "HS3ST1       3.076180   3.796722  3.736890   6.745770   3.859489   3.336679   \n",
       "ABP1         3.643995   3.289749  3.306772   3.290169   3.361698   3.577479   \n",
       "WNT16        2.730148   2.902667  2.935304   3.189503   2.835848   3.036598   \n",
       "HECW1        3.075611   2.674371  3.246909   3.001303   2.778510   2.812926   \n",
       "MAD1L1       5.485238   5.682445  4.111315   5.325992   5.161292   6.486319   \n",
       "LASP1        4.530159   4.723579  4.591571   4.293141   4.750941   6.424801   \n",
       "SNX11        4.696593   4.971820  5.035484   4.739336   5.046363   4.874689   \n",
       "TMEM176A     3.543446   2.921362  3.448695   3.401791   3.409411   3.349065   \n",
       "...               ...        ...       ...        ...        ...        ...   \n",
       "PRSS58       2.913732   2.957712  2.908623   2.913220   2.924590   2.805834   \n",
       "CLEC5A       2.882885   2.907286  2.859608   2.907639   2.871217   2.863003   \n",
       "ZNF578       2.827134   2.716170  2.870628   2.653077   2.901043   2.674094   \n",
       "DIO3OS       3.498152   3.134175  3.624569   3.428026   3.505836   3.442485   \n",
       "UBE2CP1      9.102221  10.947940  9.170254  10.503122  11.328646  11.008080   \n",
       "LINC00638    2.973991   3.357499  3.293073   3.479271   3.595077   3.550282   \n",
       "OR4C13       2.910828   3.029896  2.950666   2.865286   2.845514   2.600062   \n",
       "CEP95        6.468250   6.105404  6.787414   6.996554   6.494273   6.969322   \n",
       "SMIM6        3.608694   3.509509  7.677502   3.124435   3.583158   3.289929   \n",
       "SLC35G6      2.946378   3.525515  3.201922   3.207881   3.080393   3.327731   \n",
       "LINC00596    3.184840   3.065742  2.869266   2.969559   3.009178   3.108361   \n",
       "OR4N3P       2.931340   2.792758  3.499758   3.128158   5.826540   3.263766   \n",
       "MRPL46       8.220662   8.078510  8.766834   8.663546   8.826113   8.603450   \n",
       "C15orf37     2.957060   3.019703  3.156294   3.105757   3.280863   3.058039   \n",
       "SH3RF3-AS1   3.572554   3.388511  3.307052   3.298423   3.342639   3.495746   \n",
       "LINC00657    9.472126   9.748871  9.491885   9.181071   9.947403   9.576864   \n",
       "MOCS1P1      3.902595   3.221467  3.683660   3.539041   3.489571   3.479204   \n",
       "GOLGA6L7P    3.649731   3.503329  3.866463   3.881780   3.527467   3.744933   \n",
       "HPR          2.790603   2.853155  2.947796   2.911892   3.017686   2.785442   \n",
       "MIA          3.439633   3.459250  3.680356   3.685443   3.591036   3.898051   \n",
       "LINC00514    3.264254   3.314727  3.169682   4.254346   4.631837   8.683069   \n",
       "OR1D5        3.201629   3.569253  3.923083   3.736702   3.396205   3.729224   \n",
       "ZNF234       3.878922   4.361398  4.535106   3.903117   4.675023   4.335110   \n",
       "MYH4         2.745669   2.459203  2.611597   2.718814   2.586323   2.497412   \n",
       "LINC00526    5.102353   4.874740  4.504059   4.950010   5.532821   3.100561   \n",
       "PPY2         3.080394   3.233059  3.036383   2.970800   2.991137   3.040448   \n",
       "KRT18P55     3.378913   3.648132  3.259655   3.386533   3.554597   3.136316   \n",
       "POLRMTP1     3.191797   3.022160  2.934753   2.931548   3.168497   3.024960   \n",
       "UBL5P2       9.466545   9.267838  9.174437   9.781957   9.235654   9.594467   \n",
       "TBC1D3P5     3.214997   3.340621  3.450427   3.052209   3.299910   3.340264   \n",
       "\n",
       "               BT-549        C32    CAL-120    CAL-148    ...          SW837  \\\n",
       "TSPAN6       6.383148   5.542645   7.632023   8.121539    ...       8.141044   \n",
       "TNMD         2.746627   2.736643   2.964585   2.990916    ...       2.911450   \n",
       "DPM1        10.392289   9.890112  10.379553  10.359588    ...      10.072444   \n",
       "SCYL3        3.802817   3.346422   3.614794   5.680584    ...       4.531813   \n",
       "C1orf112     4.379548   3.067727   3.380681   4.056182    ...       3.619282   \n",
       "FGR          3.183691   3.253538   3.324692   3.450374    ...       3.123146   \n",
       "CFH          6.262654   3.300831   3.566350   3.723503    ...       3.159148   \n",
       "FUCA2        8.160151   8.074968   8.204530   6.201861    ...       8.743540   \n",
       "GCLC         5.726798   5.234662   5.235118   5.556517    ...       5.842489   \n",
       "NFYA         5.552501   4.348398   5.369039   5.508345    ...       4.922979   \n",
       "STPG1        3.157586   4.220588   3.596993   3.989457    ...       3.564864   \n",
       "NIPAL3       3.466931   8.421938   7.641756   6.385116    ...       6.719300   \n",
       "LAS1L        4.046791   3.834645   4.549065   4.042592    ...       3.944367   \n",
       "ENPP4        4.621198   3.344071   4.488261   4.548210    ...       5.787091   \n",
       "SEMA3F       4.582941   3.922672   4.118309   5.756912    ...       4.218778   \n",
       "CFTR         3.038568   3.010235   3.024970   2.978755    ...       2.941041   \n",
       "ANKIB1       8.147499   8.761885   8.296444   8.908791    ...       8.591520   \n",
       "KRIT1        3.598106   3.730710   3.646615   4.037117    ...       3.540595   \n",
       "RAD52        3.398061   3.420519   3.780467   3.541698    ...       3.615865   \n",
       "BAD          7.119724   7.580534   7.458409   7.036707    ...       6.010957   \n",
       "LAP3         7.277089   6.664109   6.453926   7.003621    ...       7.655741   \n",
       "CD99         8.750647  10.229438   9.460478   8.966939    ...       5.731270   \n",
       "HS3ST1       4.101128   3.482057   3.517445   3.378110    ...       4.521515   \n",
       "ABP1         3.213673   3.485379   3.350498   3.597797    ...       6.195352   \n",
       "WNT16        2.843903   2.832047   3.741032   2.846700    ...       2.852783   \n",
       "HECW1        3.046672   2.669112   2.661393   3.047161    ...       2.855329   \n",
       "MAD1L1       7.153442   9.474093   5.200431   5.371834    ...       5.503556   \n",
       "LASP1        3.998433   4.203288   4.931681   4.208903    ...       4.420156   \n",
       "SNX11        4.611066   5.218077   4.767457   5.402698    ...       5.030809   \n",
       "TMEM176A     3.305873   3.076385   2.975821   3.429175    ...       5.620342   \n",
       "...               ...        ...        ...        ...    ...            ...   \n",
       "PRSS58       2.829585   2.818304   3.043992   3.327380    ...       2.821643   \n",
       "CLEC5A       2.913607   2.875075   2.765216   2.938255    ...       2.936267   \n",
       "ZNF578       2.881317   2.669786   2.850649   2.759052    ...       2.872329   \n",
       "DIO3OS       3.692914   3.455929   3.310295   3.623235    ...       3.459257   \n",
       "UBE2CP1     11.159289  10.241567  10.941187   9.382099    ...      10.135301   \n",
       "LINC00638    3.423951   3.550613   3.214615   3.697266    ...       3.625674   \n",
       "OR4C13       2.925456   3.107405   2.654211   3.452664    ...       2.956142   \n",
       "CEP95        6.243260   6.026007   6.026643   7.178561    ...       7.288748   \n",
       "SMIM6        3.499269   3.088285   3.500628   3.559782    ...       6.740510   \n",
       "SLC35G6      3.112586   3.391988   2.949881   3.500728    ...       3.375379   \n",
       "LINC00596    3.347198   3.109302   2.965231   3.102900    ...       2.926848   \n",
       "OR4N3P       3.493448   3.000699   3.070104   3.472764    ...       3.668672   \n",
       "MRPL46       7.545215   7.865144   7.754133   8.194615    ...       8.436344   \n",
       "C15orf37     3.078014   3.149327   3.080081   3.597679    ...       2.875045   \n",
       "SH3RF3-AS1   3.387211   3.674423   3.440519   3.889395    ...       3.493689   \n",
       "LINC00657    8.787367   8.586205   9.622136   9.116460    ...       9.864919   \n",
       "MOCS1P1      3.618551   3.145488   3.183110   3.130554    ...       3.382850   \n",
       "GOLGA6L7P    3.634084   3.802010   3.529562   4.026188    ...       3.970129   \n",
       "HPR          2.603039   2.841387   2.790461   3.105338    ...       2.630562   \n",
       "MIA          4.082301   9.887219   3.588889   3.977683    ...       3.788622   \n",
       "LINC00514    3.047456   3.336458   3.665788   3.537723    ...       9.300587   \n",
       "OR1D5        3.076234   3.269096   3.134197   3.996887    ...       3.952035   \n",
       "ZNF234       4.386448   4.477071   4.841169   4.247065    ...       4.299596   \n",
       "MYH4         2.566644   2.644848   2.628932   2.654267    ...       2.420469   \n",
       "LINC00526    3.753303   3.797210   6.786925   3.973798    ...       4.479077   \n",
       "PPY2         3.144031   3.069556   2.997054   3.361569    ...       3.219672   \n",
       "KRT18P55     3.083726   3.062048   3.331134   3.413643    ...       3.012350   \n",
       "POLRMTP1     3.406266   3.185092   3.130696   3.375437    ...       2.837757   \n",
       "UBL5P2       9.333854   9.839337   9.986616   9.450962    ...       8.125303   \n",
       "TBC1D3P5     3.438851   3.207780   3.073724   3.581946    ...       3.198928   \n",
       "\n",
       "                SW900      SW948       T-24       T47D     TCCSUP   UACC-812  \\\n",
       "TSPAN6       7.755154   7.709982   7.788981   7.342996   7.401340   7.086304   \n",
       "TNMD         2.816921   3.212680   2.984905   2.819535   2.724977   2.952920   \n",
       "DPM1        10.214976  10.170757  10.558936  10.786582   9.864280  11.536803   \n",
       "SCYL3        4.388774   4.606470   3.789149   4.677363   3.843770   4.520248   \n",
       "C1orf112     3.946621   3.858040   3.674749   3.482290   4.383248   3.324127   \n",
       "FGR          3.088256   3.188375   3.199688   3.321172   3.336882   3.188895   \n",
       "CFH          7.497956   3.501447   5.233954   3.385376   3.357930   3.241747   \n",
       "FUCA2        7.841270   8.180214   7.964240   7.662135   8.089836   7.563625   \n",
       "GCLC         5.799141   6.820641   4.667093   5.906962   5.721922   4.767813   \n",
       "NFYA         5.585866   5.474809   4.926298   5.063413   4.795732   5.085422   \n",
       "STPG1        3.776654   3.665858   3.544039   3.818362   3.793957   3.827045   \n",
       "NIPAL3       6.968829   6.655483   7.562702   7.200407   6.550612   6.325523   \n",
       "LAS1L        3.782531   3.492792   4.144182   3.847817   4.226542   3.837344   \n",
       "ENPP4        4.953234   5.436127   4.701149   4.561405   3.912650   5.333513   \n",
       "SEMA3F       3.761762   4.302636   5.214318   4.518942   3.940632   4.958358   \n",
       "CFTR         3.634551   7.188601   3.099811   3.246823   3.610002   2.765688   \n",
       "ANKIB1       8.718188   7.981619   8.320088   7.900905   8.677345   7.973249   \n",
       "KRIT1        3.810870   4.137695   3.707591   3.693989   3.934370   3.573436   \n",
       "RAD52        3.379157   3.431033   3.332579   3.470023   3.220431   3.621764   \n",
       "BAD          6.846846   6.961040   7.654143   7.738740   6.506791   7.462899   \n",
       "LAP3         8.062102   5.654547   6.684534   5.759920   5.541195   6.418024   \n",
       "CD99         6.928679   8.992775   9.691453   7.951767   8.323406   9.198415   \n",
       "HS3ST1       5.857313   4.274328   3.632953   3.069348   3.183156   3.936523   \n",
       "ABP1         3.325421   7.850185   3.473305   3.263429   3.224062   3.441179   \n",
       "WNT16        2.853366   2.812539   2.888368   2.910818   2.921735   2.761468   \n",
       "HECW1        2.849081   2.677311   2.829970   2.821788   2.752960   2.920763   \n",
       "MAD1L1       4.679315   7.683906   6.269770   4.958479   5.003898   6.214460   \n",
       "LASP1        4.291471   4.572707   4.829535   4.126406   4.667485   5.741565   \n",
       "SNX11        5.025006   4.762145   5.069310   5.187392   5.241098   4.646291   \n",
       "TMEM176A     3.037889   6.241351   3.115563   3.555581   3.193063   5.646760   \n",
       "...               ...        ...        ...        ...        ...        ...   \n",
       "PRSS58       2.786863   2.985265   2.845151   2.881435   3.747818   2.822185   \n",
       "CLEC5A       2.873464   3.094612   2.827086   2.987454   2.780661   2.898078   \n",
       "ZNF578       2.818878   2.734593   2.742695   2.947602   2.824600   2.714856   \n",
       "DIO3OS       3.473977   3.556191   3.380172   3.588807   3.509469   3.618053   \n",
       "UBE2CP1     10.495289  10.749901  11.221197  11.233535  10.899278   9.046075   \n",
       "LINC00638    3.212535   3.601367   3.467733   3.573795   3.424304   3.404818   \n",
       "OR4C13       2.825633   3.085107   2.988314   3.057237   2.926035   2.847841   \n",
       "CEP95        6.732115   7.239201   6.688247   6.924229   6.268029   6.828407   \n",
       "SMIM6        3.609881   6.135534   3.544795   3.699950   3.435613   3.377913   \n",
       "SLC35G6      3.000302   3.770793   2.997961   3.066558   2.963289   3.310942   \n",
       "LINC00596    3.075315   3.201215   3.114260   2.945957   3.189769   2.722790   \n",
       "OR4N3P       3.098503   3.994643   3.494848   3.243701   3.327722   2.904468   \n",
       "MRPL46       8.429868   8.878589   8.427807   8.668263   8.151076   8.339814   \n",
       "C15orf37     3.158818   3.139445   3.135205   3.941021   2.812329   3.191560   \n",
       "SH3RF3-AS1   3.264042   3.626219   3.219390   3.338095   3.452632   3.657555   \n",
       "LINC00657    8.882914   9.281960   9.530058   9.048254   8.798876   9.218044   \n",
       "MOCS1P1      3.255666   3.540850   3.172379   3.431699   3.914902   3.975558   \n",
       "GOLGA6L7P    4.108772   4.565392   4.323577   4.143307   3.454142   3.391522   \n",
       "HPR          2.744761   2.766801   2.819483   2.813953   2.709272   2.884169   \n",
       "MIA          3.772547   4.178984   3.706254   4.039565   3.671843   4.213348   \n",
       "LINC00514    3.283884   3.148844   3.205160   3.164661   3.244645   3.377764   \n",
       "OR1D5        3.592234   3.892404   4.722517   4.068742   3.129759   3.285953   \n",
       "ZNF234       3.901565   4.136612   4.058997   4.372890   4.238990   4.309004   \n",
       "MYH4         2.580622   3.745408   2.542529   2.526370   2.468235   2.592263   \n",
       "LINC00526    5.170182   5.996199   4.105723   4.234477   5.248192   4.471384   \n",
       "PPY2         3.226851   3.311019   3.190357   3.295970   3.244465   3.135298   \n",
       "KRT18P55     3.161274   3.344123   3.785186   3.082722   3.045701   3.735873   \n",
       "POLRMTP1     2.829626   3.079624   3.078025   2.995339   3.057605   2.853571   \n",
       "UBL5P2       9.471560   9.272901   9.385839   9.217796   9.246567   9.616495   \n",
       "TBC1D3P5     3.192203   3.525726   3.350846   3.437583   3.247812   3.523841   \n",
       "\n",
       "              UM-UC-3      VCaP   VM-CUB-1  \n",
       "TSPAN6       6.410431  5.348023   7.187071  \n",
       "TNMD         2.795879  2.988278   2.691417  \n",
       "DPM1        10.326887  9.000925  10.184775  \n",
       "SCYL3        3.512380  4.306414   3.512961  \n",
       "C1orf112     3.291974  3.414812   3.823379  \n",
       "FGR          3.308299  3.352145   3.322545  \n",
       "CFH          5.719281  3.596993   5.631177  \n",
       "FUCA2        8.663654  7.196524   8.434965  \n",
       "GCLC         5.448271  5.519796   5.250324  \n",
       "NFYA         5.058603  5.160911   4.947160  \n",
       "STPG1        3.690896  3.383226   3.736243  \n",
       "NIPAL3       6.475256  7.600511   7.167051  \n",
       "LAS1L        4.344883  4.227789   4.822374  \n",
       "ENPP4        3.943886  4.305540   4.615197  \n",
       "SEMA3F       4.887619  4.157245   4.122925  \n",
       "CFTR         3.211279  3.463208   3.009863  \n",
       "ANKIB1       8.471688  7.732612   8.208733  \n",
       "KRIT1        3.982073  3.889208   3.842057  \n",
       "RAD52        4.626460  3.501948   3.420404  \n",
       "BAD          6.419810  9.196114   7.648273  \n",
       "LAP3         6.238463  5.397888   6.133582  \n",
       "CD99         8.016087  8.697365   8.166390  \n",
       "HS3ST1       3.063334  3.341049   5.959631  \n",
       "ABP1         3.423523  3.294335   3.229629  \n",
       "WNT16        2.940464  2.937517   3.461068  \n",
       "HECW1        2.937170  2.938455   2.838418  \n",
       "MAD1L1       4.335608  4.531748   5.809043  \n",
       "LASP1        4.005830  4.005251   4.455299  \n",
       "SNX11        4.546235  4.555568   4.879591  \n",
       "TMEM176A     3.243171  3.536854   3.650592  \n",
       "...               ...       ...        ...  \n",
       "PRSS58       2.813012  2.865009   2.827539  \n",
       "CLEC5A       2.974589  2.936993   2.934071  \n",
       "ZNF578       2.805740  2.872519   2.846660  \n",
       "DIO3OS       3.619355  4.239149   3.595024  \n",
       "UBE2CP1     11.554995  9.876791  11.661603  \n",
       "LINC00638    3.354366  3.550056   3.372026  \n",
       "OR4C13       3.019718  2.639676   2.934086  \n",
       "CEP95        6.172780  6.577474   6.624370  \n",
       "SMIM6        3.647021  4.108694   3.694118  \n",
       "SLC35G6      3.187519  3.155445   3.583261  \n",
       "LINC00596    2.984552  3.216597   3.073545  \n",
       "OR4N3P       3.419681  3.349971   3.122308  \n",
       "MRPL46       7.788280  8.818152   8.983863  \n",
       "C15orf37     3.155568  2.967439   3.102254  \n",
       "SH3RF3-AS1   3.363031  3.227857   3.295718  \n",
       "LINC00657    8.349385  8.840221   8.886559  \n",
       "MOCS1P1      3.665399  4.382022   3.913042  \n",
       "GOLGA6L7P    3.760134  4.535952   3.916097  \n",
       "HPR          2.726429  2.811859   2.776810  \n",
       "MIA          3.780613  3.688854   3.802038  \n",
       "LINC00514    3.463670  3.277527   3.211911  \n",
       "OR1D5        3.666239  3.221485   3.992597  \n",
       "ZNF234       4.830290  4.618169   4.389972  \n",
       "MYH4         2.634019  2.617327   2.651644  \n",
       "LINC00526    5.422379  3.496213   4.058739  \n",
       "PPY2         3.407639  3.299581   3.109451  \n",
       "KRT18P55     3.385810  3.335831   3.589427  \n",
       "POLRMTP1     3.321254  3.386745   3.469339  \n",
       "UBL5P2       8.601714  8.319282   9.270088  \n",
       "TBC1D3P5     3.519523  3.364994   3.445858  \n",
       "\n",
       "[17419 rows x 83 columns]"
      ]
     },
     "execution_count": 10,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "gex"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "Index(['TSPAN6', 'TNMD', 'DPM1', 'SCYL3', 'C1orf112', 'FGR', 'CFH', 'FUCA2',\n",
       "       'GCLC', 'NFYA', \n",
       "       ...\n",
       "       'LINC00514', 'OR1D5', 'ZNF234', 'MYH4', 'LINC00526', 'PPY2', 'KRT18P55',\n",
       "       'POLRMTP1', 'UBL5P2', 'TBC1D3P5'],\n",
       "      dtype='object', length=17419)"
      ]
     },
     "execution_count": 11,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "gex.index"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Cell_line</th>\n",
       "      <th>Gene</th>\n",
       "      <th>Mutation</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "Empty DataFrame\n",
       "Columns: [Cell_line, Gene, Mutation]\n",
       "Index: []"
      ]
     },
     "execution_count": 12,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "cgm_cols = ['Cell_line', 'Gene', 'Mutation']\n",
    "cgm = pd.DataFrame(columns=cgm_cols)\n",
    "cgm"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "1558, 33080\n"
     ]
    }
   ],
   "source": [
    "anomalies = 0\n",
    "total = 0\n",
    "for index, row in mut.iterrows():\n",
    "    gene = row['Gene.name']\n",
    "    cell_line = row['cell_line_name']\n",
    "    \n",
    "    if (gene in gex.index and cell_line in gex.columns):\n",
    "        upper = np.mean(gex.ix[gene]) + 2*np.std(gex.ix[gene])  # mean of particular gene + 2*std\n",
    "        lower = np.mean(gex.ix[gene]) - 2*np.std(gex.ix[gene])\n",
    "        if gex.ix[gene, cell_line] < lower or gex.ix[gene, cell_line] > upper:  # if gene over or underexpressed\n",
    "            anomalies += 1\n",
    "            cgm = cgm.append(pd.DataFrame([[cell_line, gene, row['Mutation.Description']]], columns=cgm_cols), ignore_index=True)\n",
    "        total += 1\n",
    "print(str(anomalies) + ', ' + str(total))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "{'Complex - compound substitution',\n",
       " 'Complex - deletion inframe',\n",
       " 'Complex - frameshift',\n",
       " 'Complex - insertion inframe',\n",
       " 'Deletion - Frameshift',\n",
       " 'Deletion - In frame',\n",
       " 'Insertion - Frameshift',\n",
       " 'Insertion - In frame',\n",
       " 'Nonstop extension',\n",
       " 'Substitution - Missense',\n",
       " 'Substitution - Nonsense',\n",
       " 'Unknown'}"
      ]
     },
     "execution_count": 14,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "set(mut['Mutation.Description'].values)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "cgm.to_csv('Molecular_expanded/cell_gene_mut.csv', index_col=False)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "substitution - missense: changes the amino acid, could be big or small effect\n",
    "substitution - nonsense: original amino acid changed to stop codon, protein terminates - useless protein\n",
    "frameshifts: most likely useless protein"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {
    "collapsed": true
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0.047097944377267234"
      ]
     },
     "execution_count": 14,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "1558/33080  # 3 std, no coding silent"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {
    "collapsed": true
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0.047132078901918006"
      ]
     },
     "execution_count": 15,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "2074/44004  # 3 std, yes coding silent"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "metadata": {
    "collapsed": true
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0.01127170257249341"
      ]
     },
     "execution_count": 17,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "496/44004  # 2 std, no coding silent"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {
    "collapsed": true
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0.011094316807738815"
      ]
     },
     "execution_count": 19,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "367/33080  # 2 std, yes coding silent"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Possible features to include:\n",
    "- num mutations\n",
    "- num impactful mutations (i.e. differentially expressed corresponding gene/cell_line)\n",
    "- weighted mutations: heavier weight to frameshifts, lower weights to missense substitutions, etc. (prob not good idea, would be arbitrary weights)\n",
    "- num each type of mutation\n",
    "- cluster of mutations?\n",
    "- drug target correlation with mutated genes \n",
    "    - 1 feature: number of targets corresponding to mutated gene\n",
    "    - 2 features: 1 feature for compound_a targets, another for compound_b"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Model"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "from sklearn.ensemble import GradientBoostingRegressor\n",
    "from sklearn import cross_validation, metrics\n",
    "from scipy.stats import stats"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "df = pd.DataFrame.from_csv('Train_data/with_interaction_biogrid.csv')\n",
    "#df = df.drop(['A_HBD', 'B_HBD', 'A_Lipinski', 'B_Lipinski', 'A_ALogP/XLogP', 'B_ALogP/XLogP'], axis=1)\n",
    "df = df.drop(['A_HBD', 'B_HBD', 'A_PSA', 'B_PSA', 'A_ALogP/XLogP', 'B_ALogP/XLogP', 'A_Lipinski', 'B_Lipinski'], axis=1)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "def pearson(y, y_pred):\n",
    "    return stats.pearsonr(y, y_pred)[0]\n",
    "pearson_scorer = metrics.make_scorer(pearson)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Original"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 16,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "df = df.iloc[np.random.permutation(len(df))]\n",
    "y = df['SYNERGY_SCORE'].values\n",
    "X = pd.get_dummies(df.drop('SYNERGY_SCORE', axis=1), columns=['CELL_LINE', 'COMPOUND_A', 'COMPOUND_B', 'Disease_area']).values"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "0.640785891285\n",
      "0.632122136304\n",
      "0.647732287352\n"
     ]
    }
   ],
   "source": [
    "for i in range(3):\n",
    "    gbr = GradientBoostingRegressor(n_estimators=1000, max_depth=5, loss='huber',\n",
    "                                        max_features='log2', learning_rate=0.03)\n",
    "    pearsons = cross_validation.cross_val_score(gbr, X, y, scoring=pearson_scorer, cv=5)\n",
    "    print(np.mean(pearsons))"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Test features"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "**confirmed beneficial:** # impactful mutations"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "8"
      ]
     },
     "execution_count": 21,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "cgm = pd.DataFrame.from_csv('Molecular_expanded/cell_gene_mut.csv')\n",
    "np.sum(cgm['Cell_line']=='HCC1806')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 22,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "df['Num_mut'] = 0\n",
    "for i, row in df.iterrows():\n",
    "    df.set_value( i, 'Num_mut', np.sum(cgm['Cell_line']==row['CELL_LINE']) )"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 23,
   "metadata": {
    "collapsed": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>CELL_LINE</th>\n",
       "      <th>COMPOUND_A</th>\n",
       "      <th>COMPOUND_B</th>\n",
       "      <th>MAX_CONC_A</th>\n",
       "      <th>MAX_CONC_B</th>\n",
       "      <th>IC50_A</th>\n",
       "      <th>H_A</th>\n",
       "      <th>Einf_A</th>\n",
       "      <th>IC50_B</th>\n",
       "      <th>H_B</th>\n",
       "      <th>...</th>\n",
       "      <th>B_#RotBonds</th>\n",
       "      <th>B_Arom Rings</th>\n",
       "      <th>B_Heavy atoms</th>\n",
       "      <th>B_QED</th>\n",
       "      <th>GEX_CLUSTER</th>\n",
       "      <th>THERAPY_CLUSTER</th>\n",
       "      <th>Disease_area</th>\n",
       "      <th>Target_share</th>\n",
       "      <th>Target_interaction</th>\n",
       "      <th>Num_mut</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>520</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>AKT_SGK</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.305450</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>20.899430</td>\n",
       "      <td>0.339596</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>5.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>35.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>0</td>\n",
       "      <td>2</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>925</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>PIM1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>76.200113</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.80000</td>\n",
       "      <td>5</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1357</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.294224</td>\n",
       "      <td>1.338853</td>\n",
       "      <td>29.938770</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>6.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.39000</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2062</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>PIP5K1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.353652</td>\n",
       "      <td>2.714720</td>\n",
       "      <td>...</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>313</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>AKT</td>\n",
       "      <td>PIP5K1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>4</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>897</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.375405</td>\n",
       "      <td>0.995064</td>\n",
       "      <td>11.053630</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>6.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.39000</td>\n",
       "      <td>2</td>\n",
       "      <td>2</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1883</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>PIM1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.396748</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>80.898154</td>\n",
       "      <td>0.258670</td>\n",
       "      <td>1.069386</td>\n",
       "      <td>...</td>\n",
       "      <td>3.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.80000</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>620</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>ALK_IGFR</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.238087</td>\n",
       "      <td>1.223534</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.316964</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>2</td>\n",
       "      <td>3</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2122</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>PIK3CB_PIK3CD</td>\n",
       "      <td>SLC16A4</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>6</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>914</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>PIK3CA_4</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.332840</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>67.099430</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>5.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.74000</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.333333</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1443</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>ESR1</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.211207</td>\n",
       "      <td>2.015569</td>\n",
       "      <td>14.288577</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>943</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>SLC16A4</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>60</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>ADAM17</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1</td>\n",
       "      <td>75</td>\n",
       "      <td>0.347729</td>\n",
       "      <td>1.262986</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>2</td>\n",
       "      <td>2</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>329</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>AKT</td>\n",
       "      <td>TNKS_PARP6</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.014137</td>\n",
       "      <td>2.020364</td>\n",
       "      <td>1.726334</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>1.472415</td>\n",
       "      <td>...</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>0</td>\n",
       "      <td>3</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>459</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>PIK3C_2</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.402489</td>\n",
       "      <td>3.846099</td>\n",
       "      <td>13.567076</td>\n",
       "      <td>0.258454</td>\n",
       "      <td>2.427085</td>\n",
       "      <td>...</td>\n",
       "      <td>4.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>29.000</td>\n",
       "      <td>0.82000</td>\n",
       "      <td>2</td>\n",
       "      <td>3</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1922</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>SLC16A4</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.230684</td>\n",
       "      <td>1.836554</td>\n",
       "      <td>...</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>96</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>ADAM17</td>\n",
       "      <td>PIK3CB_PIK3CD</td>\n",
       "      <td>1</td>\n",
       "      <td>75</td>\n",
       "      <td>0.186067</td>\n",
       "      <td>1.679096</td>\n",
       "      <td>90.483032</td>\n",
       "      <td>75.000000</td>\n",
       "      <td>0.190587</td>\n",
       "      <td>...</td>\n",
       "      <td>4.289</td>\n",
       "      <td>2.737</td>\n",
       "      <td>30.490</td>\n",
       "      <td>0.62948</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2028</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>PARP1</td>\n",
       "      <td>PIK3CB_PIK3CD</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>0.332653</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>91.999854</td>\n",
       "      <td>1.822097</td>\n",
       "      <td>0.935272</td>\n",
       "      <td>...</td>\n",
       "      <td>4.289</td>\n",
       "      <td>2.737</td>\n",
       "      <td>30.490</td>\n",
       "      <td>0.62948</td>\n",
       "      <td>5</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.333333</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>844</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>FASN</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.294044</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>91.999896</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>5.000</td>\n",
       "      <td>5.000</td>\n",
       "      <td>35.000</td>\n",
       "      <td>0.39000</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>445</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.308851</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>23.099316</td>\n",
       "      <td>0.324660</td>\n",
       "      <td>2.311037</td>\n",
       "      <td>...</td>\n",
       "      <td>5.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>35.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>2</td>\n",
       "      <td>3</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>73</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>ADAM17</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>1</td>\n",
       "      <td>75</td>\n",
       "      <td>0.327702</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>26.498929</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>5.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>35.000</td>\n",
       "      <td>0.43000</td>\n",
       "      <td>2</td>\n",
       "      <td>2</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1385</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.171634</td>\n",
       "      <td>1.474611</td>\n",
       "      <td>9.696650</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2107</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>PIK3CB_PIK3CD</td>\n",
       "      <td>PIP5K1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>ADAM17</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>1</td>\n",
       "      <td>75</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>11.564</td>\n",
       "      <td>2.847</td>\n",
       "      <td>60.555</td>\n",
       "      <td>0.19713</td>\n",
       "      <td>2</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1588</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>TNKS_PARP6</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.012166</td>\n",
       "      <td>1.828625</td>\n",
       "      <td>1.733648</td>\n",
       "      <td>0.011699</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.068</td>\n",
       "      <td>2.597</td>\n",
       "      <td>23.849</td>\n",
       "      <td>0.63639</td>\n",
       "      <td>3</td>\n",
       "      <td>2</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>860</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>8.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.46000</td>\n",
       "      <td>3</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>286</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>AKT</td>\n",
       "      <td>PIK3C_2</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.348873</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>16.597769</td>\n",
       "      <td>0.322093</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>4.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>29.000</td>\n",
       "      <td>0.82000</td>\n",
       "      <td>1</td>\n",
       "      <td>2</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>253</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>AKT</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.386971</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>8.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.46000</td>\n",
       "      <td>6</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>500</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>AKT_SGK</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.353839</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>8.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.46000</td>\n",
       "      <td>2</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1418</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>ESR1</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.000100</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>92.282976</td>\n",
       "      <td>0.000100</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>...</td>\n",
       "      <td>8.000</td>\n",
       "      <td>4.000</td>\n",
       "      <td>34.000</td>\n",
       "      <td>0.46000</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2046</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>PIM1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.342982</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>86.999703</td>\n",
       "      <td>0.303925</td>\n",
       "      <td>5.353186</td>\n",
       "      <td>...</td>\n",
       "      <td>3.000</td>\n",
       "      <td>2.000</td>\n",
       "      <td>27.000</td>\n",
       "      <td>0.80000</td>\n",
       "      <td>5</td>\n",
       "      <td>0</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.333333</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1831</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.192089</td>\n",
       "      <td>1.505775</td>\n",
       "      <td>0.520345</td>\n",
       "      <td>0.244049</td>\n",
       "      <td>1.005696</td>\n",
       "      <td>...</td>\n",
       "      <td>4.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>32.000</td>\n",
       "      <td>0.63000</td>\n",
       "      <td>1</td>\n",
       "      <td>3</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>ADAM17</td>\n",
       "      <td>AKT</td>\n",
       "      <td>1</td>\n",
       "      <td>75</td>\n",
       "      <td>0.313992</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>63.399635</td>\n",
       "      <td>75.000000</td>\n",
       "      <td>0.392570</td>\n",
       "      <td>...</td>\n",
       "      <td>6.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>30.000</td>\n",
       "      <td>0.57000</td>\n",
       "      <td>4</td>\n",
       "      <td>1</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>136</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>AKT</td>\n",
       "      <td>ATR_4</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.510325</td>\n",
       "      <td>2.634897</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>1.991181</td>\n",
       "      <td>...</td>\n",
       "      <td>3.247</td>\n",
       "      <td>2.574</td>\n",
       "      <td>29.574</td>\n",
       "      <td>0.65759</td>\n",
       "      <td>0</td>\n",
       "      <td>3</td>\n",
       "      <td>Breast</td>\n",
       "      <td>0</td>\n",
       "      <td>0.500000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>108</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>AKT</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0.219929</td>\n",
       "      <td>1.699701</td>\n",
       "      <td>23.856267</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>1.343412</td>\n",
       "      <td>...</td>\n",
       "      <td>3.000</td>\n",
       "      <td>3.000</td>\n",
       "      <td>31.000</td>\n",
       "      <td>0.70000</td>\n",
       "      <td>4</td>\n",
       "      <td>3</td>\n",
       "      <td>Breast</td>\n",
       "      <td>1</td>\n",
       "      <td>2.000000</td>\n",
       "      <td>8</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>35 rows × 32 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "     CELL_LINE     COMPOUND_A     COMPOUND_B  MAX_CONC_A  MAX_CONC_B  \\\n",
       "520    HCC1806        AKT_SGK          PIK3C           1           1   \n",
       "925    HCC1806    BCL2_BCL2L1           PIM1           1           1   \n",
       "1357   HCC1806           ERBB        MAP2K_1           1           1   \n",
       "2062   HCC1806          PIK3C         PIP5K1           1           1   \n",
       "313    HCC1806            AKT         PIP5K1           1           1   \n",
       "897    HCC1806    BCL2_BCL2L1        MAP2K_1           1           1   \n",
       "1883   HCC1806        MAP2K_1           PIM1           1           1   \n",
       "620    HCC1806       ALK_IGFR         MTOR_1           1           1   \n",
       "2122   HCC1806  PIK3CB_PIK3CD        SLC16A4           1           1   \n",
       "914    HCC1806    BCL2_BCL2L1       PIK3CA_4           1           1   \n",
       "1443   HCC1806           ESR1         MTOR_1           1           1   \n",
       "943    HCC1806    BCL2_BCL2L1        SLC16A4           1           1   \n",
       "60     HCC1806         ADAM17         MTOR_1           1          75   \n",
       "329    HCC1806            AKT     TNKS_PARP6           1           1   \n",
       "459    HCC1806          AKT_1        PIK3C_2           1           1   \n",
       "1922   HCC1806        MAP2K_1        SLC16A4           1           1   \n",
       "96     HCC1806         ADAM17  PIK3CB_PIK3CD           1          75   \n",
       "2028   HCC1806          PARP1  PIK3CB_PIK3CD           1           3   \n",
       "844    HCC1806    BCL2_BCL2L1           FASN           1           1   \n",
       "445    HCC1806          AKT_1          PIK3C           1           1   \n",
       "73     HCC1806         ADAM17          PIK3C           1          75   \n",
       "1385   HCC1806           ERBB         MTOR_1           1           1   \n",
       "2107   HCC1806  PIK3CB_PIK3CD         PIP5K1           1           1   \n",
       "19     HCC1806         ADAM17    BCL2_BCL2L1           1          75   \n",
       "1588   HCC1806           FGFR     TNKS_PARP6           1           1   \n",
       "860    HCC1806    BCL2_BCL2L1           FGFR           1           1   \n",
       "286    HCC1806            AKT        PIK3C_2           1           1   \n",
       "253    HCC1806            AKT           FGFR           1           1   \n",
       "500    HCC1806        AKT_SGK           FGFR           1           1   \n",
       "1418   HCC1806           ESR1           FGFR           1           1   \n",
       "2046   HCC1806          PIK3C           PIM1           1           1   \n",
       "1831   HCC1806        MAP2K_1         MTOR_1           1           1   \n",
       "7      HCC1806         ADAM17            AKT           1          75   \n",
       "136    HCC1806            AKT          ATR_4           1           1   \n",
       "108    HCC1806            AKT          AKT_1           1           1   \n",
       "\n",
       "        IC50_A        H_A      Einf_A     IC50_B        H_B   ...     \\\n",
       "520   0.305450  10.000000   20.899430   0.339596  10.000000   ...      \n",
       "925   1.000000  10.000000   76.200113   1.000000   0.000000   ...      \n",
       "1357  0.294224   1.338853   29.938770   1.000000   0.000000   ...      \n",
       "2062  1.000000   0.000000  100.000000   0.353652   2.714720   ...      \n",
       "313   1.000000   0.000000  100.000000   1.000000  10.000000   ...      \n",
       "897   0.375405   0.995064   11.053630   1.000000   0.000000   ...      \n",
       "1883  0.396748  10.000000   80.898154   0.258670   1.069386   ...      \n",
       "620   0.238087   1.223534    0.000000   0.316964  10.000000   ...      \n",
       "2122  1.000000   0.000000  100.000000   1.000000  10.000000   ...      \n",
       "914   0.332840  10.000000   67.099430   1.000000   0.000000   ...      \n",
       "1443  0.211207   2.015569   14.288577   1.000000   0.000000   ...      \n",
       "943   1.000000   0.000000  100.000000   1.000000   0.000000   ...      \n",
       "60    0.347729   1.262986    0.000000   1.000000   0.000000   ...      \n",
       "329   0.014137   2.020364    1.726334   1.000000   1.472415   ...      \n",
       "459   0.402489   3.846099   13.567076   0.258454   2.427085   ...      \n",
       "1922  1.000000   0.000000  100.000000   0.230684   1.836554   ...      \n",
       "96    0.186067   1.679096   90.483032  75.000000   0.190587   ...      \n",
       "2028  0.332653  10.000000   91.999854   1.822097   0.935272   ...      \n",
       "844   0.294044  10.000000   91.999896   1.000000  10.000000   ...      \n",
       "445   0.308851  10.000000   23.099316   0.324660   2.311037   ...      \n",
       "73    0.327702  10.000000   26.498929   1.000000   0.000000   ...      \n",
       "1385  0.171634   1.474611    9.696650   1.000000   0.000000   ...      \n",
       "2107  1.000000   0.000000  100.000000   1.000000   0.000000   ...      \n",
       "19    1.000000   0.000000  100.000000   1.000000   0.000000   ...      \n",
       "1588  0.012166   1.828625    1.733648   0.011699  10.000000   ...      \n",
       "860   1.000000   0.000000  100.000000   1.000000   0.000000   ...      \n",
       "286   0.348873  10.000000   16.597769   0.322093  10.000000   ...      \n",
       "253   1.000000   0.000000  100.000000   0.386971  10.000000   ...      \n",
       "500   1.000000   0.000000  100.000000   0.353839  10.000000   ...      \n",
       "1418  0.000100   0.100000   92.282976   0.000100   0.100000   ...      \n",
       "2046  0.342982  10.000000   86.999703   0.303925   5.353186   ...      \n",
       "1831  0.192089   1.505775    0.520345   0.244049   1.005696   ...      \n",
       "7     0.313992  10.000000   63.399635  75.000000   0.392570   ...      \n",
       "136   0.510325   2.634897    0.000000   1.000000   1.991181   ...      \n",
       "108   0.219929   1.699701   23.856267   1.000000   1.343412   ...      \n",
       "\n",
       "      B_#RotBonds  B_Arom Rings  B_Heavy atoms    B_QED  GEX_CLUSTER  \\\n",
       "520         5.000         4.000         35.000  0.43000            0   \n",
       "925         3.000         2.000         27.000  0.80000            5   \n",
       "1357        6.000         3.000         27.000  0.39000            1   \n",
       "2062        3.068         2.597         23.849  0.63639            1   \n",
       "313         3.068         2.597         23.849  0.63639            4   \n",
       "897         6.000         3.000         27.000  0.39000            2   \n",
       "1883        3.000         2.000         27.000  0.80000            2   \n",
       "620         4.000         3.000         32.000  0.63000            2   \n",
       "2122        3.068         2.597         23.849  0.63639            6   \n",
       "914         5.000         2.000         30.000  0.74000            1   \n",
       "1443        4.000         3.000         32.000  0.63000            1   \n",
       "943         3.068         2.597         23.849  0.63639            1   \n",
       "60          4.000         3.000         32.000  0.63000            2   \n",
       "329         3.068         2.597         23.849  0.63639            0   \n",
       "459         4.000         2.000         29.000  0.82000            2   \n",
       "1922        3.068         2.597         23.849  0.63639            1   \n",
       "96          4.289         2.737         30.490  0.62948            2   \n",
       "2028        4.289         2.737         30.490  0.62948            5   \n",
       "844         5.000         5.000         35.000  0.39000            2   \n",
       "445         5.000         4.000         35.000  0.43000            2   \n",
       "73          5.000         4.000         35.000  0.43000            2   \n",
       "1385        4.000         3.000         32.000  0.63000            1   \n",
       "2107        3.068         2.597         23.849  0.63639            2   \n",
       "19         11.564         2.847         60.555  0.19713            2   \n",
       "1588        3.068         2.597         23.849  0.63639            3   \n",
       "860         8.000         4.000         34.000  0.46000            3   \n",
       "286         4.000         2.000         29.000  0.82000            1   \n",
       "253         8.000         4.000         34.000  0.46000            6   \n",
       "500         8.000         4.000         34.000  0.46000            2   \n",
       "1418        8.000         4.000         34.000  0.46000            0   \n",
       "2046        3.000         2.000         27.000  0.80000            5   \n",
       "1831        4.000         3.000         32.000  0.63000            1   \n",
       "7           6.000         3.000         30.000  0.57000            4   \n",
       "136         3.247         2.574         29.574  0.65759            0   \n",
       "108         3.000         3.000         31.000  0.70000            4   \n",
       "\n",
       "      THERAPY_CLUSTER  Disease_area  Target_share  Target_interaction  Num_mut  \n",
       "520                 2        Breast             0            1.000000        8  \n",
       "925                 1        Breast             0            0.500000        8  \n",
       "1357                2        Breast             0            1.000000        8  \n",
       "2062                0        Breast             0            0.000000        8  \n",
       "313                 0        Breast             0            0.000000        8  \n",
       "897                 2        Breast             0            0.500000        8  \n",
       "1883                0        Breast             0            0.500000        8  \n",
       "620                 3        Breast             0            0.500000        8  \n",
       "2122                1        Breast             0            0.000000        8  \n",
       "914                 1        Breast             0            0.333333        8  \n",
       "1443                2        Breast             0            0.500000        8  \n",
       "943                 1        Breast             0            0.000000        8  \n",
       "60                  2        Breast             0            0.000000        8  \n",
       "329                 3        Breast             0            0.000000        8  \n",
       "459                 3        Breast             0            1.000000        8  \n",
       "1922                0        Breast             0            0.000000        8  \n",
       "96                  1        Breast             0            0.000000        8  \n",
       "2028                0        Breast             0            0.333333        8  \n",
       "844                 1        Breast             0            0.500000        8  \n",
       "445                 3        Breast             0            1.000000        8  \n",
       "73                  2        Breast             0            0.000000        8  \n",
       "1385                2        Breast             0            1.000000        8  \n",
       "2107                1        Breast             0            0.000000        8  \n",
       "19                  1        Breast             0            0.000000        8  \n",
       "1588                2        Breast             0            0.000000        8  \n",
       "860                 1        Breast             0            0.500000        8  \n",
       "286                 2        Breast             0            1.000000        8  \n",
       "253                 1        Breast             0            0.500000        8  \n",
       "500                 0        Breast             0            0.500000        8  \n",
       "1418                1        Breast             0            0.500000        8  \n",
       "2046                0        Breast             0            0.333333        8  \n",
       "1831                3        Breast             0            0.500000        8  \n",
       "7                   1        Breast             0            0.000000        8  \n",
       "136                 3        Breast             0            0.500000        8  \n",
       "108                 3        Breast             1            2.000000        8  \n",
       "\n",
       "[35 rows x 32 columns]"
      ]
     },
     "execution_count": 23,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "df.loc[df['CELL_LINE']=='HCC1806']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 128,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "0.646524796559\n",
      "0.646488713182\n",
      "0.651325003012\n"
     ]
    }
   ],
   "source": [
    "y = df['SYNERGY_SCORE'].values\n",
    "X = pd.get_dummies(df.drop(['SYNERGY_SCORE'], axis=1), columns=['CELL_LINE', 'COMPOUND_A', 'COMPOUND_B', 'Disease_area']).values\n",
    "for i in range(3):\n",
    "    gbr = GradientBoostingRegressor(n_estimators=1000, max_depth=5, loss='huber',\n",
    "                                        max_features='log2', learning_rate=0.03)\n",
    "    pearsons = cross_validation.cross_val_score(gbr, X, y, scoring=pearson_scorer, cv=5)\n",
    "    print(np.mean(pearsons))"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "**testing**: # drug targets matching mutations"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 25,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "drug_targ = pd.DataFrame.from_csv('Drug_expanded/targets.csv')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 151,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "dfmod = df.copy()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 152,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "# dfmod['A_mut_targ'] = 0\n",
    "# dfmod['B_mut_targ'] = 0\n",
    "# for i, row in dfmod.iterrows():\n",
    "#     a_targs = drug_targ.ix[row['COMPOUND_A'], 'Target'].split(',')\n",
    "#     b_targs = drug_targ.ix[row['COMPOUND_B'], 'Target'].split(',')\n",
    "#     cell_muts = mut.loc[mut['cell_line_name']==row['CELL_LINE']]  # mutation data with given cell line\n",
    "    \n",
    "#     a_count, b_count = 0, 0\n",
    "#     match_genes = list(cell_muts['Gene.name'].values) \n",
    "#     for t in a_targs:\n",
    "#         a_count += match_genes.count(t)   # add matching genes\n",
    "#     for t2 in b_targs:\n",
    "#         b_count += match_genes.count(t2)\n",
    "        \n",
    "#     dfmod.set_value(i, 'A_mut_targ', a_count)\n",
    "#     dfmod.set_value(i, 'B_mut_targ', b_count)\n",
    "dfmod['mut_targ'] = 0\n",
    "for i, row in dfmod.iterrows():\n",
    "    targs = drug_targ.ix[row['COMPOUND_A'], 'Target'].split(',')\n",
    "    b_targs = drug_targ.ix[row['COMPOUND_B'], 'Target'].split(',')\n",
    "    targs.extend(b_targs) \n",
    "    cell_muts = mut.loc[mut['cell_line_name']==row['CELL_LINE']]  # mutation data with given cell line\n",
    "    \n",
    "    count = 0\n",
    "    match_genes = list(cell_muts['Gene.name'].values) \n",
    "    for t in targs:\n",
    "        count += match_genes.count(t)   # add matching genes\n",
    "    \n",
    "    dfmod.set_value(i, 'mut_targ', count)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 153,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "ymod = dfmod['SYNERGY_SCORE'].values\n",
    "Xmod = pd.get_dummies(dfmod.drop(['SYNERGY_SCORE'], axis=1), columns=['CELL_LINE', 'COMPOUND_A', 'COMPOUND_B', 'Disease_area']).values"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 154,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "0.643037523153\n",
      "0.64896924948\n",
      "0.629600780687\n"
     ]
    }
   ],
   "source": [
    "for i in range(3):\n",
    "    gbr = GradientBoostingRegressor(n_estimators=1000, max_depth=5, loss='huber',\n",
    "                                        max_features='log2', learning_rate=0.03)\n",
    "    pearsons = cross_validation.cross_val_score(gbr, Xmod, ymod, scoring=pearson_scorer, cv=5) #scoring=pearson_scorer, \n",
    "    print(np.mean(pearsons))"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "#### Feature importances"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 67,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "feats = ['MAX_CONC_A', 'MAX_CONC_B',\n",
    "       'IC50_A', 'H_A', 'Einf_A', 'IC50_B', 'H_B', 'Einf_B',\n",
    "       'A_HBA', 'A_cLogP', 'A_MW', 'A_PSA', 'A_#RotBonds', 'A_Arom Rings',\n",
    "       'A_Heavy atoms', 'A_QED', 'B_HBA', 'B_cLogP', 'B_MW', 'B_PSA',\n",
    "       'B_#RotBonds', 'B_Arom Rings', 'B_Heavy atoms', 'B_QED', 'GEX_CLUSTER',\n",
    "       'THERAPY_CLUSTER', 'Target_share', 'Target_interaction',\n",
    "       'Num_mut', 'A_mut_targ', 'B_mut_targ']\n",
    "gbr_feats = GradientBoostingRegressor(n_estimators=1000, max_depth=5, loss='huber',\n",
    "                                        max_features='log2', learning_rate=0.03).fit(Xmod, ymod)\n",
    "importances = gbr_feats.feature_importances_[:31]\n",
    "fi = dict(zip(feats, importances))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 68,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[('Target_share', 0.00090197514694565981),\n",
       " ('B_mut_targ', 0.0032695832721409499),\n",
       " ('A_mut_targ', 0.0055002414978961248),\n",
       " ('B_Arom Rings', 0.011273049722495789),\n",
       " ('A_Arom Rings', 0.01247217650983712),\n",
       " ('A_#RotBonds', 0.012473312610611943),\n",
       " ('A_MW', 0.012642715020346557),\n",
       " ('B_Heavy atoms', 0.012994888923562984),\n",
       " ('B_MW', 0.013409700041813908),\n",
       " ('MAX_CONC_B', 0.013467117441383751),\n",
       " ('B_HBA', 0.013486904365615648),\n",
       " ('B_#RotBonds', 0.013541796776282516),\n",
       " ('A_HBA', 0.013789176602523096),\n",
       " ('MAX_CONC_A', 0.014532811885980533),\n",
       " ('Target_interaction', 0.014560664225792422),\n",
       " ('A_cLogP', 0.014782137637530814),\n",
       " ('A_Heavy atoms', 0.01503544744898856),\n",
       " ('B_PSA', 0.015048859803033658),\n",
       " ('B_cLogP', 0.015214686860483708),\n",
       " ('A_QED', 0.015216874255654581),\n",
       " ('THERAPY_CLUSTER', 0.015617116996023523),\n",
       " ('B_QED', 0.016553037914311366),\n",
       " ('A_PSA', 0.018308085984354638),\n",
       " ('Num_mut', 0.018385276347624303),\n",
       " ('GEX_CLUSTER', 0.022806737656399262),\n",
       " ('H_B', 0.037730728166039285),\n",
       " ('IC50_B', 0.038192501742208486),\n",
       " ('IC50_A', 0.039658325822586701),\n",
       " ('Einf_A', 0.041226903842516413),\n",
       " ('Einf_B', 0.042923301151428395),\n",
       " ('H_A', 0.044954570058190556)]"
      ]
     },
     "execution_count": 68,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "import operator\n",
    "fi_sorted = sorted(fi.items(), key=operator.itemgetter(1))\n",
    "fi_sorted"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {
    "collapsed": false
   },
   "source": [
    "## TSGene DB"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "ts1 = pd.DataFrame.from_csv('Molecular_expanded/tumor_supressors_tsgeneDB.csv')\n",
    "ts2 = pd.DataFrame.from_csv('Molecular_expanded/Human_TSGs.csv')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 70,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "716\n",
      "1217\n",
      "639\n"
     ]
    }
   ],
   "source": [
    "ts1_genes = ts1['Gene_symbol'].values\n",
    "ts2_genes = ts2['GeneSymbol'].values\n",
    "ts_genes = set(ts1_genes) & set(ts2_genes)\n",
    "print(len(ts1_genes))\n",
    "print(len(ts2_genes))\n",
    "print(len(ts_genes))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 95,
   "metadata": {
    "collapsed": false,
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>22RV1</th>\n",
       "      <th>647-V</th>\n",
       "      <th>A549</th>\n",
       "      <th>BFTC-905</th>\n",
       "      <th>BT-20</th>\n",
       "      <th>BT-474</th>\n",
       "      <th>BT-549</th>\n",
       "      <th>C32</th>\n",
       "      <th>CAL-120</th>\n",
       "      <th>CAL-148</th>\n",
       "      <th>...</th>\n",
       "      <th>SW837</th>\n",
       "      <th>SW900</th>\n",
       "      <th>SW948</th>\n",
       "      <th>T-24</th>\n",
       "      <th>T47D</th>\n",
       "      <th>TCCSUP</th>\n",
       "      <th>UACC-812</th>\n",
       "      <th>UM-UC-3</th>\n",
       "      <th>VCaP</th>\n",
       "      <th>VM-CUB-1</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>ZYX</th>\n",
       "      <td>3.941590</td>\n",
       "      <td>5.204366</td>\n",
       "      <td>4.912069</td>\n",
       "      <td>4.664766</td>\n",
       "      <td>5.133911</td>\n",
       "      <td>4.941155</td>\n",
       "      <td>5.655587</td>\n",
       "      <td>6.215595</td>\n",
       "      <td>4.415610</td>\n",
       "      <td>4.231359</td>\n",
       "      <td>...</td>\n",
       "      <td>4.560421</td>\n",
       "      <td>4.558872</td>\n",
       "      <td>5.163735</td>\n",
       "      <td>4.741197</td>\n",
       "      <td>3.921108</td>\n",
       "      <td>5.492629</td>\n",
       "      <td>4.283938</td>\n",
       "      <td>5.805750</td>\n",
       "      <td>4.355522</td>\n",
       "      <td>5.129551</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GADD45G</th>\n",
       "      <td>6.884257</td>\n",
       "      <td>2.816534</td>\n",
       "      <td>3.121235</td>\n",
       "      <td>3.297829</td>\n",
       "      <td>4.095581</td>\n",
       "      <td>6.002934</td>\n",
       "      <td>2.820640</td>\n",
       "      <td>2.987849</td>\n",
       "      <td>2.758568</td>\n",
       "      <td>7.025054</td>\n",
       "      <td>...</td>\n",
       "      <td>3.303425</td>\n",
       "      <td>3.049742</td>\n",
       "      <td>3.727669</td>\n",
       "      <td>3.019107</td>\n",
       "      <td>4.108757</td>\n",
       "      <td>3.094141</td>\n",
       "      <td>5.361575</td>\n",
       "      <td>3.093164</td>\n",
       "      <td>4.279718</td>\n",
       "      <td>3.209478</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SASH1</th>\n",
       "      <td>4.296142</td>\n",
       "      <td>5.933057</td>\n",
       "      <td>4.261597</td>\n",
       "      <td>3.626372</td>\n",
       "      <td>6.256945</td>\n",
       "      <td>4.680919</td>\n",
       "      <td>5.366439</td>\n",
       "      <td>6.963580</td>\n",
       "      <td>5.152033</td>\n",
       "      <td>5.823953</td>\n",
       "      <td>...</td>\n",
       "      <td>5.439911</td>\n",
       "      <td>4.513081</td>\n",
       "      <td>5.117161</td>\n",
       "      <td>5.817025</td>\n",
       "      <td>4.687558</td>\n",
       "      <td>5.393250</td>\n",
       "      <td>5.591640</td>\n",
       "      <td>4.734545</td>\n",
       "      <td>5.249760</td>\n",
       "      <td>5.337148</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MAP4K1</th>\n",
       "      <td>3.016747</td>\n",
       "      <td>3.040741</td>\n",
       "      <td>2.874760</td>\n",
       "      <td>3.005089</td>\n",
       "      <td>3.119357</td>\n",
       "      <td>3.428802</td>\n",
       "      <td>2.970357</td>\n",
       "      <td>3.181064</td>\n",
       "      <td>2.941828</td>\n",
       "      <td>3.246280</td>\n",
       "      <td>...</td>\n",
       "      <td>3.583015</td>\n",
       "      <td>2.934833</td>\n",
       "      <td>3.087185</td>\n",
       "      <td>3.030658</td>\n",
       "      <td>3.203557</td>\n",
       "      <td>2.836363</td>\n",
       "      <td>3.105644</td>\n",
       "      <td>2.856904</td>\n",
       "      <td>3.378733</td>\n",
       "      <td>3.032270</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CST5</th>\n",
       "      <td>3.161125</td>\n",
       "      <td>3.372700</td>\n",
       "      <td>3.006167</td>\n",
       "      <td>3.060336</td>\n",
       "      <td>3.153971</td>\n",
       "      <td>3.465202</td>\n",
       "      <td>3.225971</td>\n",
       "      <td>3.312577</td>\n",
       "      <td>2.990222</td>\n",
       "      <td>3.248122</td>\n",
       "      <td>...</td>\n",
       "      <td>3.354106</td>\n",
       "      <td>2.976170</td>\n",
       "      <td>3.359341</td>\n",
       "      <td>3.222965</td>\n",
       "      <td>3.214966</td>\n",
       "      <td>3.301471</td>\n",
       "      <td>3.366584</td>\n",
       "      <td>3.086696</td>\n",
       "      <td>2.919890</td>\n",
       "      <td>3.240980</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CADM3</th>\n",
       "      <td>3.314637</td>\n",
       "      <td>3.031378</td>\n",
       "      <td>3.178965</td>\n",
       "      <td>3.166439</td>\n",
       "      <td>3.291688</td>\n",
       "      <td>3.139113</td>\n",
       "      <td>2.954189</td>\n",
       "      <td>3.345058</td>\n",
       "      <td>3.101887</td>\n",
       "      <td>3.749908</td>\n",
       "      <td>...</td>\n",
       "      <td>3.279966</td>\n",
       "      <td>3.152755</td>\n",
       "      <td>3.271687</td>\n",
       "      <td>3.140584</td>\n",
       "      <td>3.508587</td>\n",
       "      <td>3.295337</td>\n",
       "      <td>3.216208</td>\n",
       "      <td>3.226101</td>\n",
       "      <td>3.545501</td>\n",
       "      <td>3.207830</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SIRT2</th>\n",
       "      <td>5.239788</td>\n",
       "      <td>4.618523</td>\n",
       "      <td>5.333696</td>\n",
       "      <td>4.189891</td>\n",
       "      <td>6.008036</td>\n",
       "      <td>5.356842</td>\n",
       "      <td>6.069756</td>\n",
       "      <td>6.456122</td>\n",
       "      <td>5.388351</td>\n",
       "      <td>5.613326</td>\n",
       "      <td>...</td>\n",
       "      <td>4.765165</td>\n",
       "      <td>4.797608</td>\n",
       "      <td>5.608583</td>\n",
       "      <td>4.777952</td>\n",
       "      <td>4.625962</td>\n",
       "      <td>4.590109</td>\n",
       "      <td>6.597426</td>\n",
       "      <td>4.590714</td>\n",
       "      <td>4.892502</td>\n",
       "      <td>4.796700</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>RPL10</th>\n",
       "      <td>6.832162</td>\n",
       "      <td>6.870249</td>\n",
       "      <td>6.994830</td>\n",
       "      <td>5.960790</td>\n",
       "      <td>6.776642</td>\n",
       "      <td>7.536564</td>\n",
       "      <td>7.961996</td>\n",
       "      <td>7.074002</td>\n",
       "      <td>6.763491</td>\n",
       "      <td>7.620725</td>\n",
       "      <td>...</td>\n",
       "      <td>9.784303</td>\n",
       "      <td>7.035165</td>\n",
       "      <td>6.628275</td>\n",
       "      <td>7.411194</td>\n",
       "      <td>6.081554</td>\n",
       "      <td>6.848690</td>\n",
       "      <td>7.067343</td>\n",
       "      <td>7.041893</td>\n",
       "      <td>7.485062</td>\n",
       "      <td>7.221335</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>NF2</th>\n",
       "      <td>4.462146</td>\n",
       "      <td>4.915568</td>\n",
       "      <td>3.858324</td>\n",
       "      <td>4.342475</td>\n",
       "      <td>4.391052</td>\n",
       "      <td>4.046314</td>\n",
       "      <td>4.549624</td>\n",
       "      <td>4.507336</td>\n",
       "      <td>5.372245</td>\n",
       "      <td>3.868760</td>\n",
       "      <td>...</td>\n",
       "      <td>3.870313</td>\n",
       "      <td>4.744224</td>\n",
       "      <td>3.910822</td>\n",
       "      <td>5.238765</td>\n",
       "      <td>4.147239</td>\n",
       "      <td>4.937637</td>\n",
       "      <td>4.246255</td>\n",
       "      <td>5.259157</td>\n",
       "      <td>4.263257</td>\n",
       "      <td>5.374764</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>DKK1</th>\n",
       "      <td>6.325388</td>\n",
       "      <td>7.621139</td>\n",
       "      <td>12.122421</td>\n",
       "      <td>10.948822</td>\n",
       "      <td>4.157821</td>\n",
       "      <td>8.083121</td>\n",
       "      <td>7.840029</td>\n",
       "      <td>3.226377</td>\n",
       "      <td>12.114559</td>\n",
       "      <td>9.266994</td>\n",
       "      <td>...</td>\n",
       "      <td>6.712088</td>\n",
       "      <td>10.716862</td>\n",
       "      <td>2.956745</td>\n",
       "      <td>11.130120</td>\n",
       "      <td>10.434384</td>\n",
       "      <td>11.225248</td>\n",
       "      <td>5.282694</td>\n",
       "      <td>7.454326</td>\n",
       "      <td>2.767777</td>\n",
       "      <td>12.219899</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SAFB2</th>\n",
       "      <td>6.247057</td>\n",
       "      <td>5.784535</td>\n",
       "      <td>5.362967</td>\n",
       "      <td>6.032035</td>\n",
       "      <td>5.334102</td>\n",
       "      <td>6.533180</td>\n",
       "      <td>6.120087</td>\n",
       "      <td>5.897436</td>\n",
       "      <td>6.093817</td>\n",
       "      <td>5.776581</td>\n",
       "      <td>...</td>\n",
       "      <td>5.317287</td>\n",
       "      <td>5.647735</td>\n",
       "      <td>5.877850</td>\n",
       "      <td>5.450609</td>\n",
       "      <td>5.416330</td>\n",
       "      <td>5.402793</td>\n",
       "      <td>5.377506</td>\n",
       "      <td>6.160044</td>\n",
       "      <td>6.097196</td>\n",
       "      <td>6.195752</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>JUP</th>\n",
       "      <td>7.441110</td>\n",
       "      <td>9.659033</td>\n",
       "      <td>9.375186</td>\n",
       "      <td>9.156500</td>\n",
       "      <td>8.329441</td>\n",
       "      <td>9.966623</td>\n",
       "      <td>4.256758</td>\n",
       "      <td>3.856673</td>\n",
       "      <td>6.038497</td>\n",
       "      <td>8.184365</td>\n",
       "      <td>...</td>\n",
       "      <td>9.812986</td>\n",
       "      <td>8.338691</td>\n",
       "      <td>8.791620</td>\n",
       "      <td>7.626389</td>\n",
       "      <td>9.272512</td>\n",
       "      <td>7.231455</td>\n",
       "      <td>9.112013</td>\n",
       "      <td>3.607236</td>\n",
       "      <td>7.893582</td>\n",
       "      <td>8.422437</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GJA1</th>\n",
       "      <td>4.810230</td>\n",
       "      <td>3.326393</td>\n",
       "      <td>5.647902</td>\n",
       "      <td>4.225823</td>\n",
       "      <td>3.623304</td>\n",
       "      <td>3.263222</td>\n",
       "      <td>5.719701</td>\n",
       "      <td>3.573138</td>\n",
       "      <td>3.600511</td>\n",
       "      <td>3.658770</td>\n",
       "      <td>...</td>\n",
       "      <td>3.611492</td>\n",
       "      <td>5.006607</td>\n",
       "      <td>3.376350</td>\n",
       "      <td>4.258637</td>\n",
       "      <td>3.617048</td>\n",
       "      <td>5.036670</td>\n",
       "      <td>3.661299</td>\n",
       "      <td>5.264573</td>\n",
       "      <td>3.266141</td>\n",
       "      <td>4.700218</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PLEKHO1</th>\n",
       "      <td>4.640663</td>\n",
       "      <td>4.590659</td>\n",
       "      <td>4.685167</td>\n",
       "      <td>4.428003</td>\n",
       "      <td>3.975914</td>\n",
       "      <td>4.319659</td>\n",
       "      <td>7.770932</td>\n",
       "      <td>7.625111</td>\n",
       "      <td>5.563551</td>\n",
       "      <td>8.469644</td>\n",
       "      <td>...</td>\n",
       "      <td>3.114768</td>\n",
       "      <td>6.540184</td>\n",
       "      <td>3.895871</td>\n",
       "      <td>6.643725</td>\n",
       "      <td>4.181517</td>\n",
       "      <td>8.156359</td>\n",
       "      <td>5.346501</td>\n",
       "      <td>5.879837</td>\n",
       "      <td>4.831115</td>\n",
       "      <td>5.403898</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>MAD1L1</th>\n",
       "      <td>5.485238</td>\n",
       "      <td>5.682445</td>\n",
       "      <td>4.111315</td>\n",
       "      <td>5.325992</td>\n",
       "      <td>5.161292</td>\n",
       "      <td>6.486319</td>\n",
       "      <td>7.153442</td>\n",
       "      <td>9.474093</td>\n",
       "      <td>5.200431</td>\n",
       "      <td>5.371834</td>\n",
       "      <td>...</td>\n",
       "      <td>5.503556</td>\n",
       "      <td>4.679315</td>\n",
       "      <td>7.683906</td>\n",
       "      <td>6.269770</td>\n",
       "      <td>4.958479</td>\n",
       "      <td>5.003898</td>\n",
       "      <td>6.214460</td>\n",
       "      <td>4.335608</td>\n",
       "      <td>4.531748</td>\n",
       "      <td>5.809043</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ING5</th>\n",
       "      <td>3.833961</td>\n",
       "      <td>3.755047</td>\n",
       "      <td>3.788858</td>\n",
       "      <td>3.941058</td>\n",
       "      <td>3.844479</td>\n",
       "      <td>4.212456</td>\n",
       "      <td>3.696306</td>\n",
       "      <td>3.546206</td>\n",
       "      <td>3.861259</td>\n",
       "      <td>4.149435</td>\n",
       "      <td>...</td>\n",
       "      <td>4.289493</td>\n",
       "      <td>3.582631</td>\n",
       "      <td>4.333733</td>\n",
       "      <td>3.733226</td>\n",
       "      <td>3.771620</td>\n",
       "      <td>3.596957</td>\n",
       "      <td>3.820713</td>\n",
       "      <td>3.925415</td>\n",
       "      <td>4.218251</td>\n",
       "      <td>3.887065</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BCL10</th>\n",
       "      <td>5.715067</td>\n",
       "      <td>6.610585</td>\n",
       "      <td>5.076287</td>\n",
       "      <td>6.707612</td>\n",
       "      <td>5.675817</td>\n",
       "      <td>5.084217</td>\n",
       "      <td>6.733035</td>\n",
       "      <td>5.111526</td>\n",
       "      <td>5.374215</td>\n",
       "      <td>5.245943</td>\n",
       "      <td>...</td>\n",
       "      <td>4.701158</td>\n",
       "      <td>6.594262</td>\n",
       "      <td>5.657223</td>\n",
       "      <td>6.776556</td>\n",
       "      <td>5.270346</td>\n",
       "      <td>5.427207</td>\n",
       "      <td>5.346090</td>\n",
       "      <td>5.711474</td>\n",
       "      <td>4.422921</td>\n",
       "      <td>6.405497</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CAMTA1</th>\n",
       "      <td>4.498801</td>\n",
       "      <td>4.510983</td>\n",
       "      <td>4.580234</td>\n",
       "      <td>4.351539</td>\n",
       "      <td>4.584816</td>\n",
       "      <td>4.642158</td>\n",
       "      <td>5.991350</td>\n",
       "      <td>5.122772</td>\n",
       "      <td>5.331344</td>\n",
       "      <td>5.364959</td>\n",
       "      <td>...</td>\n",
       "      <td>4.863907</td>\n",
       "      <td>4.687323</td>\n",
       "      <td>4.679047</td>\n",
       "      <td>4.632906</td>\n",
       "      <td>4.097423</td>\n",
       "      <td>4.472148</td>\n",
       "      <td>5.124919</td>\n",
       "      <td>4.943213</td>\n",
       "      <td>5.018374</td>\n",
       "      <td>4.437826</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GLIPR1</th>\n",
       "      <td>3.970460</td>\n",
       "      <td>6.020400</td>\n",
       "      <td>5.109596</td>\n",
       "      <td>4.622791</td>\n",
       "      <td>3.251677</td>\n",
       "      <td>3.355165</td>\n",
       "      <td>8.267947</td>\n",
       "      <td>3.830908</td>\n",
       "      <td>4.439915</td>\n",
       "      <td>3.297260</td>\n",
       "      <td>...</td>\n",
       "      <td>3.112195</td>\n",
       "      <td>5.194062</td>\n",
       "      <td>4.135682</td>\n",
       "      <td>8.243753</td>\n",
       "      <td>3.458818</td>\n",
       "      <td>8.278484</td>\n",
       "      <td>3.205508</td>\n",
       "      <td>9.180804</td>\n",
       "      <td>3.512235</td>\n",
       "      <td>8.057524</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FH</th>\n",
       "      <td>9.534454</td>\n",
       "      <td>9.086597</td>\n",
       "      <td>8.419299</td>\n",
       "      <td>8.579138</td>\n",
       "      <td>9.333008</td>\n",
       "      <td>9.285310</td>\n",
       "      <td>8.842696</td>\n",
       "      <td>8.244943</td>\n",
       "      <td>9.317453</td>\n",
       "      <td>10.068468</td>\n",
       "      <td>...</td>\n",
       "      <td>8.531076</td>\n",
       "      <td>8.945166</td>\n",
       "      <td>8.938430</td>\n",
       "      <td>9.227813</td>\n",
       "      <td>8.879167</td>\n",
       "      <td>9.488954</td>\n",
       "      <td>7.987016</td>\n",
       "      <td>8.832687</td>\n",
       "      <td>8.883004</td>\n",
       "      <td>8.972795</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TUSC2</th>\n",
       "      <td>6.299572</td>\n",
       "      <td>6.675912</td>\n",
       "      <td>6.083211</td>\n",
       "      <td>6.687928</td>\n",
       "      <td>6.581319</td>\n",
       "      <td>6.042204</td>\n",
       "      <td>6.055383</td>\n",
       "      <td>6.324480</td>\n",
       "      <td>7.480025</td>\n",
       "      <td>6.742436</td>\n",
       "      <td>...</td>\n",
       "      <td>5.054631</td>\n",
       "      <td>6.484413</td>\n",
       "      <td>6.728647</td>\n",
       "      <td>6.002979</td>\n",
       "      <td>6.759734</td>\n",
       "      <td>6.597647</td>\n",
       "      <td>6.166636</td>\n",
       "      <td>6.386104</td>\n",
       "      <td>6.518322</td>\n",
       "      <td>6.755723</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ARID2</th>\n",
       "      <td>6.961399</td>\n",
       "      <td>5.603630</td>\n",
       "      <td>6.210514</td>\n",
       "      <td>5.675540</td>\n",
       "      <td>5.466854</td>\n",
       "      <td>5.899563</td>\n",
       "      <td>5.757071</td>\n",
       "      <td>5.167250</td>\n",
       "      <td>5.239619</td>\n",
       "      <td>6.220964</td>\n",
       "      <td>...</td>\n",
       "      <td>5.538160</td>\n",
       "      <td>6.080444</td>\n",
       "      <td>5.986595</td>\n",
       "      <td>5.722316</td>\n",
       "      <td>6.286031</td>\n",
       "      <td>5.375532</td>\n",
       "      <td>4.674635</td>\n",
       "      <td>6.652278</td>\n",
       "      <td>6.029322</td>\n",
       "      <td>5.498309</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>DLEC1</th>\n",
       "      <td>3.109465</td>\n",
       "      <td>2.907546</td>\n",
       "      <td>3.110925</td>\n",
       "      <td>2.934134</td>\n",
       "      <td>2.891672</td>\n",
       "      <td>3.102339</td>\n",
       "      <td>3.035915</td>\n",
       "      <td>3.106742</td>\n",
       "      <td>2.887607</td>\n",
       "      <td>3.026003</td>\n",
       "      <td>...</td>\n",
       "      <td>3.222723</td>\n",
       "      <td>2.955758</td>\n",
       "      <td>3.095061</td>\n",
       "      <td>3.020308</td>\n",
       "      <td>3.161683</td>\n",
       "      <td>3.120874</td>\n",
       "      <td>3.021721</td>\n",
       "      <td>3.160895</td>\n",
       "      <td>3.168242</td>\n",
       "      <td>3.007760</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FOXO4</th>\n",
       "      <td>3.400629</td>\n",
       "      <td>3.567534</td>\n",
       "      <td>3.477594</td>\n",
       "      <td>3.372782</td>\n",
       "      <td>3.479097</td>\n",
       "      <td>3.533524</td>\n",
       "      <td>3.316519</td>\n",
       "      <td>3.533678</td>\n",
       "      <td>3.501036</td>\n",
       "      <td>3.632969</td>\n",
       "      <td>...</td>\n",
       "      <td>3.429158</td>\n",
       "      <td>3.262394</td>\n",
       "      <td>3.666882</td>\n",
       "      <td>3.312882</td>\n",
       "      <td>3.461983</td>\n",
       "      <td>3.292221</td>\n",
       "      <td>4.035490</td>\n",
       "      <td>3.358295</td>\n",
       "      <td>3.750215</td>\n",
       "      <td>3.231318</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>LIMD1</th>\n",
       "      <td>3.674656</td>\n",
       "      <td>3.421655</td>\n",
       "      <td>3.553268</td>\n",
       "      <td>3.210794</td>\n",
       "      <td>3.356882</td>\n",
       "      <td>3.483857</td>\n",
       "      <td>3.514544</td>\n",
       "      <td>3.410297</td>\n",
       "      <td>3.366434</td>\n",
       "      <td>3.500823</td>\n",
       "      <td>...</td>\n",
       "      <td>3.210965</td>\n",
       "      <td>3.242277</td>\n",
       "      <td>3.583009</td>\n",
       "      <td>3.344055</td>\n",
       "      <td>3.108423</td>\n",
       "      <td>3.256021</td>\n",
       "      <td>3.076322</td>\n",
       "      <td>3.651217</td>\n",
       "      <td>3.542437</td>\n",
       "      <td>3.309383</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PRDM4</th>\n",
       "      <td>7.019736</td>\n",
       "      <td>7.005515</td>\n",
       "      <td>6.596734</td>\n",
       "      <td>7.348124</td>\n",
       "      <td>6.298713</td>\n",
       "      <td>7.584770</td>\n",
       "      <td>6.834868</td>\n",
       "      <td>6.518273</td>\n",
       "      <td>6.491453</td>\n",
       "      <td>8.016437</td>\n",
       "      <td>...</td>\n",
       "      <td>7.691132</td>\n",
       "      <td>7.646865</td>\n",
       "      <td>7.323555</td>\n",
       "      <td>6.922357</td>\n",
       "      <td>6.792448</td>\n",
       "      <td>6.762302</td>\n",
       "      <td>7.096455</td>\n",
       "      <td>7.493066</td>\n",
       "      <td>7.042053</td>\n",
       "      <td>6.968328</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BMP10</th>\n",
       "      <td>3.084375</td>\n",
       "      <td>3.112843</td>\n",
       "      <td>3.028968</td>\n",
       "      <td>3.121645</td>\n",
       "      <td>3.104231</td>\n",
       "      <td>3.012876</td>\n",
       "      <td>3.274657</td>\n",
       "      <td>2.958100</td>\n",
       "      <td>2.814362</td>\n",
       "      <td>3.210728</td>\n",
       "      <td>...</td>\n",
       "      <td>3.232619</td>\n",
       "      <td>3.085870</td>\n",
       "      <td>3.168334</td>\n",
       "      <td>3.103192</td>\n",
       "      <td>3.381826</td>\n",
       "      <td>3.280269</td>\n",
       "      <td>2.890558</td>\n",
       "      <td>3.418139</td>\n",
       "      <td>3.472125</td>\n",
       "      <td>3.086108</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IDH1</th>\n",
       "      <td>10.649014</td>\n",
       "      <td>8.314822</td>\n",
       "      <td>9.931359</td>\n",
       "      <td>8.697574</td>\n",
       "      <td>11.139695</td>\n",
       "      <td>8.352754</td>\n",
       "      <td>7.541949</td>\n",
       "      <td>8.934956</td>\n",
       "      <td>7.349274</td>\n",
       "      <td>8.086308</td>\n",
       "      <td>...</td>\n",
       "      <td>8.089019</td>\n",
       "      <td>9.182878</td>\n",
       "      <td>9.734964</td>\n",
       "      <td>7.749971</td>\n",
       "      <td>8.256346</td>\n",
       "      <td>9.506883</td>\n",
       "      <td>8.513564</td>\n",
       "      <td>7.540347</td>\n",
       "      <td>9.769079</td>\n",
       "      <td>8.046071</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>RBL1</th>\n",
       "      <td>3.473077</td>\n",
       "      <td>4.209457</td>\n",
       "      <td>3.450007</td>\n",
       "      <td>3.841721</td>\n",
       "      <td>3.702836</td>\n",
       "      <td>3.227963</td>\n",
       "      <td>4.029079</td>\n",
       "      <td>3.600109</td>\n",
       "      <td>3.554048</td>\n",
       "      <td>3.910256</td>\n",
       "      <td>...</td>\n",
       "      <td>3.786910</td>\n",
       "      <td>3.711091</td>\n",
       "      <td>3.996105</td>\n",
       "      <td>4.372971</td>\n",
       "      <td>3.489254</td>\n",
       "      <td>4.825541</td>\n",
       "      <td>3.790818</td>\n",
       "      <td>3.648831</td>\n",
       "      <td>3.455339</td>\n",
       "      <td>4.903004</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ZFHX3</th>\n",
       "      <td>3.617820</td>\n",
       "      <td>4.434671</td>\n",
       "      <td>4.783307</td>\n",
       "      <td>4.039779</td>\n",
       "      <td>4.782089</td>\n",
       "      <td>4.742174</td>\n",
       "      <td>4.255525</td>\n",
       "      <td>4.009081</td>\n",
       "      <td>3.902115</td>\n",
       "      <td>4.079719</td>\n",
       "      <td>...</td>\n",
       "      <td>4.841286</td>\n",
       "      <td>3.927599</td>\n",
       "      <td>3.891125</td>\n",
       "      <td>3.654787</td>\n",
       "      <td>3.472223</td>\n",
       "      <td>3.901307</td>\n",
       "      <td>3.638695</td>\n",
       "      <td>3.396880</td>\n",
       "      <td>4.366164</td>\n",
       "      <td>3.352380</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FOXP3</th>\n",
       "      <td>2.981604</td>\n",
       "      <td>2.985216</td>\n",
       "      <td>2.915779</td>\n",
       "      <td>3.057550</td>\n",
       "      <td>2.897542</td>\n",
       "      <td>3.097103</td>\n",
       "      <td>2.887230</td>\n",
       "      <td>3.070364</td>\n",
       "      <td>2.947046</td>\n",
       "      <td>2.959116</td>\n",
       "      <td>...</td>\n",
       "      <td>2.955591</td>\n",
       "      <td>2.878231</td>\n",
       "      <td>3.020346</td>\n",
       "      <td>2.854790</td>\n",
       "      <td>3.114641</td>\n",
       "      <td>2.847317</td>\n",
       "      <td>2.931572</td>\n",
       "      <td>3.090450</td>\n",
       "      <td>2.931465</td>\n",
       "      <td>2.756575</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>LXN</th>\n",
       "      <td>4.818783</td>\n",
       "      <td>3.280697</td>\n",
       "      <td>10.088517</td>\n",
       "      <td>3.224381</td>\n",
       "      <td>3.202445</td>\n",
       "      <td>6.690447</td>\n",
       "      <td>3.367252</td>\n",
       "      <td>4.209321</td>\n",
       "      <td>7.984849</td>\n",
       "      <td>2.987428</td>\n",
       "      <td>...</td>\n",
       "      <td>3.255701</td>\n",
       "      <td>4.589068</td>\n",
       "      <td>7.106948</td>\n",
       "      <td>8.760514</td>\n",
       "      <td>3.288849</td>\n",
       "      <td>3.185465</td>\n",
       "      <td>4.172748</td>\n",
       "      <td>3.218839</td>\n",
       "      <td>6.674011</td>\n",
       "      <td>4.109363</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PARK2</th>\n",
       "      <td>3.199924</td>\n",
       "      <td>3.019583</td>\n",
       "      <td>3.139179</td>\n",
       "      <td>3.024695</td>\n",
       "      <td>3.078827</td>\n",
       "      <td>3.112272</td>\n",
       "      <td>3.127635</td>\n",
       "      <td>3.136385</td>\n",
       "      <td>2.994945</td>\n",
       "      <td>3.279128</td>\n",
       "      <td>...</td>\n",
       "      <td>3.119005</td>\n",
       "      <td>3.140177</td>\n",
       "      <td>3.093932</td>\n",
       "      <td>3.071674</td>\n",
       "      <td>3.188115</td>\n",
       "      <td>3.097080</td>\n",
       "      <td>3.383873</td>\n",
       "      <td>3.191161</td>\n",
       "      <td>3.304525</td>\n",
       "      <td>3.145199</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PRKCDBP</th>\n",
       "      <td>3.089069</td>\n",
       "      <td>3.710405</td>\n",
       "      <td>3.695032</td>\n",
       "      <td>4.252051</td>\n",
       "      <td>3.420466</td>\n",
       "      <td>3.044450</td>\n",
       "      <td>5.926926</td>\n",
       "      <td>6.331176</td>\n",
       "      <td>7.794936</td>\n",
       "      <td>3.046212</td>\n",
       "      <td>...</td>\n",
       "      <td>4.990414</td>\n",
       "      <td>4.768375</td>\n",
       "      <td>3.488477</td>\n",
       "      <td>9.369940</td>\n",
       "      <td>3.110815</td>\n",
       "      <td>3.461136</td>\n",
       "      <td>3.186216</td>\n",
       "      <td>6.821806</td>\n",
       "      <td>3.447177</td>\n",
       "      <td>6.615427</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IRF3</th>\n",
       "      <td>4.204523</td>\n",
       "      <td>4.723343</td>\n",
       "      <td>4.816416</td>\n",
       "      <td>4.649923</td>\n",
       "      <td>5.596047</td>\n",
       "      <td>4.949915</td>\n",
       "      <td>4.497195</td>\n",
       "      <td>4.355670</td>\n",
       "      <td>6.457924</td>\n",
       "      <td>4.452737</td>\n",
       "      <td>...</td>\n",
       "      <td>4.608323</td>\n",
       "      <td>4.505271</td>\n",
       "      <td>4.256386</td>\n",
       "      <td>4.399739</td>\n",
       "      <td>4.153408</td>\n",
       "      <td>4.169489</td>\n",
       "      <td>4.684565</td>\n",
       "      <td>4.282969</td>\n",
       "      <td>4.243448</td>\n",
       "      <td>4.870604</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>DDX3X</th>\n",
       "      <td>5.306141</td>\n",
       "      <td>6.203667</td>\n",
       "      <td>5.502748</td>\n",
       "      <td>5.594516</td>\n",
       "      <td>5.627455</td>\n",
       "      <td>5.395713</td>\n",
       "      <td>4.674857</td>\n",
       "      <td>4.608957</td>\n",
       "      <td>5.788192</td>\n",
       "      <td>5.460773</td>\n",
       "      <td>...</td>\n",
       "      <td>5.106087</td>\n",
       "      <td>5.179408</td>\n",
       "      <td>5.071165</td>\n",
       "      <td>5.958953</td>\n",
       "      <td>5.190119</td>\n",
       "      <td>5.937856</td>\n",
       "      <td>5.667530</td>\n",
       "      <td>4.753125</td>\n",
       "      <td>5.258761</td>\n",
       "      <td>5.891738</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>RB1</th>\n",
       "      <td>4.524552</td>\n",
       "      <td>3.096019</td>\n",
       "      <td>3.664309</td>\n",
       "      <td>3.731714</td>\n",
       "      <td>4.376842</td>\n",
       "      <td>3.503612</td>\n",
       "      <td>3.266968</td>\n",
       "      <td>3.638497</td>\n",
       "      <td>3.471136</td>\n",
       "      <td>3.117782</td>\n",
       "      <td>...</td>\n",
       "      <td>3.418880</td>\n",
       "      <td>3.711499</td>\n",
       "      <td>4.529214</td>\n",
       "      <td>4.966209</td>\n",
       "      <td>3.823842</td>\n",
       "      <td>3.189678</td>\n",
       "      <td>4.140866</td>\n",
       "      <td>4.403053</td>\n",
       "      <td>3.301463</td>\n",
       "      <td>4.279524</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>CHD5</th>\n",
       "      <td>3.192635</td>\n",
       "      <td>2.984700</td>\n",
       "      <td>3.076011</td>\n",
       "      <td>2.998725</td>\n",
       "      <td>2.897913</td>\n",
       "      <td>3.057982</td>\n",
       "      <td>2.945381</td>\n",
       "      <td>2.829288</td>\n",
       "      <td>3.107214</td>\n",
       "      <td>3.226845</td>\n",
       "      <td>...</td>\n",
       "      <td>3.013811</td>\n",
       "      <td>3.045676</td>\n",
       "      <td>3.120130</td>\n",
       "      <td>3.119147</td>\n",
       "      <td>3.392055</td>\n",
       "      <td>3.069984</td>\n",
       "      <td>3.378481</td>\n",
       "      <td>3.262041</td>\n",
       "      <td>3.315252</td>\n",
       "      <td>3.109847</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PAX6</th>\n",
       "      <td>4.028073</td>\n",
       "      <td>3.807004</td>\n",
       "      <td>3.358637</td>\n",
       "      <td>4.094261</td>\n",
       "      <td>7.130923</td>\n",
       "      <td>2.972099</td>\n",
       "      <td>6.339213</td>\n",
       "      <td>3.171753</td>\n",
       "      <td>3.762872</td>\n",
       "      <td>3.327210</td>\n",
       "      <td>...</td>\n",
       "      <td>3.492099</td>\n",
       "      <td>3.208120</td>\n",
       "      <td>4.985293</td>\n",
       "      <td>6.225009</td>\n",
       "      <td>3.140159</td>\n",
       "      <td>4.586031</td>\n",
       "      <td>3.189206</td>\n",
       "      <td>4.630888</td>\n",
       "      <td>3.300330</td>\n",
       "      <td>5.230359</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SFRP1</th>\n",
       "      <td>3.188761</td>\n",
       "      <td>3.231137</td>\n",
       "      <td>5.330982</td>\n",
       "      <td>3.041159</td>\n",
       "      <td>3.249385</td>\n",
       "      <td>3.276027</td>\n",
       "      <td>4.025181</td>\n",
       "      <td>7.213512</td>\n",
       "      <td>12.452676</td>\n",
       "      <td>3.456186</td>\n",
       "      <td>...</td>\n",
       "      <td>3.064195</td>\n",
       "      <td>7.087948</td>\n",
       "      <td>3.430133</td>\n",
       "      <td>2.960842</td>\n",
       "      <td>3.206793</td>\n",
       "      <td>3.082273</td>\n",
       "      <td>3.230377</td>\n",
       "      <td>4.047380</td>\n",
       "      <td>3.671804</td>\n",
       "      <td>3.130926</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>NDRG2</th>\n",
       "      <td>4.677503</td>\n",
       "      <td>3.486320</td>\n",
       "      <td>5.630512</td>\n",
       "      <td>3.900957</td>\n",
       "      <td>7.101863</td>\n",
       "      <td>5.069445</td>\n",
       "      <td>3.445795</td>\n",
       "      <td>5.315459</td>\n",
       "      <td>3.798068</td>\n",
       "      <td>5.926873</td>\n",
       "      <td>...</td>\n",
       "      <td>4.824400</td>\n",
       "      <td>4.060437</td>\n",
       "      <td>7.035718</td>\n",
       "      <td>3.794874</td>\n",
       "      <td>5.348102</td>\n",
       "      <td>3.874384</td>\n",
       "      <td>5.506952</td>\n",
       "      <td>4.149994</td>\n",
       "      <td>6.128871</td>\n",
       "      <td>4.154323</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>TMPRSS11A</th>\n",
       "      <td>2.870502</td>\n",
       "      <td>2.833078</td>\n",
       "      <td>2.735700</td>\n",
       "      <td>4.267372</td>\n",
       "      <td>2.823523</td>\n",
       "      <td>2.855180</td>\n",
       "      <td>2.914614</td>\n",
       "      <td>2.861470</td>\n",
       "      <td>2.796175</td>\n",
       "      <td>2.904799</td>\n",
       "      <td>...</td>\n",
       "      <td>2.980691</td>\n",
       "      <td>2.914748</td>\n",
       "      <td>2.959246</td>\n",
       "      <td>2.902457</td>\n",
       "      <td>2.999052</td>\n",
       "      <td>2.855444</td>\n",
       "      <td>2.795403</td>\n",
       "      <td>2.965562</td>\n",
       "      <td>2.971710</td>\n",
       "      <td>2.923276</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PYHIN1</th>\n",
       "      <td>3.175882</td>\n",
       "      <td>2.905062</td>\n",
       "      <td>3.067200</td>\n",
       "      <td>3.092009</td>\n",
       "      <td>2.890412</td>\n",
       "      <td>3.071138</td>\n",
       "      <td>2.990523</td>\n",
       "      <td>3.008619</td>\n",
       "      <td>2.949791</td>\n",
       "      <td>3.211010</td>\n",
       "      <td>...</td>\n",
       "      <td>3.030422</td>\n",
       "      <td>2.905128</td>\n",
       "      <td>3.086540</td>\n",
       "      <td>2.948810</td>\n",
       "      <td>2.953135</td>\n",
       "      <td>2.999250</td>\n",
       "      <td>3.234356</td>\n",
       "      <td>3.142873</td>\n",
       "      <td>3.277236</td>\n",
       "      <td>2.899782</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>DFNA5</th>\n",
       "      <td>2.986476</td>\n",
       "      <td>8.676396</td>\n",
       "      <td>9.401452</td>\n",
       "      <td>8.007681</td>\n",
       "      <td>3.053527</td>\n",
       "      <td>3.123360</td>\n",
       "      <td>7.748814</td>\n",
       "      <td>7.737281</td>\n",
       "      <td>7.391120</td>\n",
       "      <td>2.517137</td>\n",
       "      <td>...</td>\n",
       "      <td>2.876618</td>\n",
       "      <td>8.327849</td>\n",
       "      <td>2.890864</td>\n",
       "      <td>8.345326</td>\n",
       "      <td>3.198059</td>\n",
       "      <td>7.457824</td>\n",
       "      <td>3.139161</td>\n",
       "      <td>7.746453</td>\n",
       "      <td>3.156094</td>\n",
       "      <td>7.551902</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SMARCA2</th>\n",
       "      <td>7.990434</td>\n",
       "      <td>6.028194</td>\n",
       "      <td>5.571964</td>\n",
       "      <td>3.854994</td>\n",
       "      <td>7.516653</td>\n",
       "      <td>4.882019</td>\n",
       "      <td>4.913034</td>\n",
       "      <td>5.722671</td>\n",
       "      <td>5.400255</td>\n",
       "      <td>7.194757</td>\n",
       "      <td>...</td>\n",
       "      <td>5.219110</td>\n",
       "      <td>6.374250</td>\n",
       "      <td>6.112657</td>\n",
       "      <td>5.679948</td>\n",
       "      <td>5.538017</td>\n",
       "      <td>6.124031</td>\n",
       "      <td>5.665645</td>\n",
       "      <td>5.771700</td>\n",
       "      <td>7.663862</td>\n",
       "      <td>5.523442</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>SPRY2</th>\n",
       "      <td>5.602050</td>\n",
       "      <td>6.285734</td>\n",
       "      <td>7.042680</td>\n",
       "      <td>8.086614</td>\n",
       "      <td>6.170305</td>\n",
       "      <td>3.785336</td>\n",
       "      <td>8.041924</td>\n",
       "      <td>10.164763</td>\n",
       "      <td>8.455994</td>\n",
       "      <td>5.062883</td>\n",
       "      <td>...</td>\n",
       "      <td>5.079592</td>\n",
       "      <td>8.171010</td>\n",
       "      <td>8.846313</td>\n",
       "      <td>7.051564</td>\n",
       "      <td>4.560252</td>\n",
       "      <td>7.500709</td>\n",
       "      <td>5.316408</td>\n",
       "      <td>8.603669</td>\n",
       "      <td>4.966854</td>\n",
       "      <td>6.273701</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>BAX</th>\n",
       "      <td>5.969015</td>\n",
       "      <td>7.447411</td>\n",
       "      <td>7.982287</td>\n",
       "      <td>6.696344</td>\n",
       "      <td>6.679763</td>\n",
       "      <td>6.569358</td>\n",
       "      <td>7.352075</td>\n",
       "      <td>7.870207</td>\n",
       "      <td>7.129632</td>\n",
       "      <td>7.091143</td>\n",
       "      <td>...</td>\n",
       "      <td>7.278849</td>\n",
       "      <td>6.945622</td>\n",
       "      <td>6.456304</td>\n",
       "      <td>7.187385</td>\n",
       "      <td>6.429532</td>\n",
       "      <td>7.421762</td>\n",
       "      <td>6.372965</td>\n",
       "      <td>7.637897</td>\n",
       "      <td>6.117035</td>\n",
       "      <td>7.539109</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>IGF2R</th>\n",
       "      <td>7.573372</td>\n",
       "      <td>7.623085</td>\n",
       "      <td>6.956941</td>\n",
       "      <td>7.458472</td>\n",
       "      <td>6.841867</td>\n",
       "      <td>8.020542</td>\n",
       "      <td>8.909259</td>\n",
       "      <td>8.821869</td>\n",
       "      <td>6.900228</td>\n",
       "      <td>8.274394</td>\n",
       "      <td>...</td>\n",
       "      <td>8.144050</td>\n",
       "      <td>8.166317</td>\n",
       "      <td>7.424834</td>\n",
       "      <td>7.464031</td>\n",
       "      <td>7.958298</td>\n",
       "      <td>9.105481</td>\n",
       "      <td>7.378177</td>\n",
       "      <td>7.445280</td>\n",
       "      <td>6.781037</td>\n",
       "      <td>7.428893</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PCDH10</th>\n",
       "      <td>2.982132</td>\n",
       "      <td>3.406444</td>\n",
       "      <td>3.173127</td>\n",
       "      <td>2.889307</td>\n",
       "      <td>3.000220</td>\n",
       "      <td>3.541436</td>\n",
       "      <td>3.211485</td>\n",
       "      <td>2.989946</td>\n",
       "      <td>3.089691</td>\n",
       "      <td>2.967150</td>\n",
       "      <td>...</td>\n",
       "      <td>2.963680</td>\n",
       "      <td>3.095914</td>\n",
       "      <td>3.197740</td>\n",
       "      <td>2.994741</td>\n",
       "      <td>3.113202</td>\n",
       "      <td>3.607689</td>\n",
       "      <td>3.081531</td>\n",
       "      <td>3.542770</td>\n",
       "      <td>3.097435</td>\n",
       "      <td>3.117340</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PHLPP1</th>\n",
       "      <td>4.002743</td>\n",
       "      <td>3.666011</td>\n",
       "      <td>4.102836</td>\n",
       "      <td>3.775922</td>\n",
       "      <td>3.649520</td>\n",
       "      <td>3.989413</td>\n",
       "      <td>3.982365</td>\n",
       "      <td>4.925186</td>\n",
       "      <td>3.548347</td>\n",
       "      <td>3.695069</td>\n",
       "      <td>...</td>\n",
       "      <td>3.642714</td>\n",
       "      <td>3.310469</td>\n",
       "      <td>4.359392</td>\n",
       "      <td>3.548311</td>\n",
       "      <td>3.623291</td>\n",
       "      <td>3.875227</td>\n",
       "      <td>4.185407</td>\n",
       "      <td>3.539272</td>\n",
       "      <td>3.901840</td>\n",
       "      <td>3.910575</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PAFAH1B1</th>\n",
       "      <td>7.884138</td>\n",
       "      <td>8.000928</td>\n",
       "      <td>8.313141</td>\n",
       "      <td>7.204942</td>\n",
       "      <td>7.677200</td>\n",
       "      <td>7.761747</td>\n",
       "      <td>8.396872</td>\n",
       "      <td>7.858884</td>\n",
       "      <td>7.778578</td>\n",
       "      <td>7.629253</td>\n",
       "      <td>...</td>\n",
       "      <td>7.295742</td>\n",
       "      <td>8.349058</td>\n",
       "      <td>7.732011</td>\n",
       "      <td>7.986203</td>\n",
       "      <td>7.589771</td>\n",
       "      <td>7.832008</td>\n",
       "      <td>7.142825</td>\n",
       "      <td>8.433927</td>\n",
       "      <td>7.990676</td>\n",
       "      <td>7.939682</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>DLEU2</th>\n",
       "      <td>2.676907</td>\n",
       "      <td>3.547069</td>\n",
       "      <td>2.787142</td>\n",
       "      <td>2.836224</td>\n",
       "      <td>3.227312</td>\n",
       "      <td>2.872764</td>\n",
       "      <td>3.115254</td>\n",
       "      <td>2.842766</td>\n",
       "      <td>2.592059</td>\n",
       "      <td>2.936144</td>\n",
       "      <td>...</td>\n",
       "      <td>2.524722</td>\n",
       "      <td>2.498934</td>\n",
       "      <td>3.583962</td>\n",
       "      <td>3.281191</td>\n",
       "      <td>2.691534</td>\n",
       "      <td>3.158298</td>\n",
       "      <td>2.885179</td>\n",
       "      <td>3.224540</td>\n",
       "      <td>2.767189</td>\n",
       "      <td>3.510358</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>E2F1</th>\n",
       "      <td>6.001907</td>\n",
       "      <td>5.983110</td>\n",
       "      <td>4.897051</td>\n",
       "      <td>5.070400</td>\n",
       "      <td>5.506922</td>\n",
       "      <td>5.591237</td>\n",
       "      <td>5.757543</td>\n",
       "      <td>5.702826</td>\n",
       "      <td>5.529260</td>\n",
       "      <td>6.549320</td>\n",
       "      <td>...</td>\n",
       "      <td>5.587431</td>\n",
       "      <td>5.116335</td>\n",
       "      <td>5.872019</td>\n",
       "      <td>5.994388</td>\n",
       "      <td>4.672919</td>\n",
       "      <td>5.576714</td>\n",
       "      <td>4.618166</td>\n",
       "      <td>4.508136</td>\n",
       "      <td>5.472550</td>\n",
       "      <td>5.805323</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>PALB2</th>\n",
       "      <td>6.276984</td>\n",
       "      <td>7.250447</td>\n",
       "      <td>6.948425</td>\n",
       "      <td>7.045179</td>\n",
       "      <td>7.356645</td>\n",
       "      <td>6.748739</td>\n",
       "      <td>7.134663</td>\n",
       "      <td>6.155690</td>\n",
       "      <td>6.344497</td>\n",
       "      <td>8.088288</td>\n",
       "      <td>...</td>\n",
       "      <td>7.671000</td>\n",
       "      <td>6.838830</td>\n",
       "      <td>6.738839</td>\n",
       "      <td>7.207518</td>\n",
       "      <td>6.887917</td>\n",
       "      <td>7.821759</td>\n",
       "      <td>6.551294</td>\n",
       "      <td>6.681040</td>\n",
       "      <td>5.669767</td>\n",
       "      <td>7.502697</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>FAM188A</th>\n",
       "      <td>7.737958</td>\n",
       "      <td>5.917429</td>\n",
       "      <td>6.112347</td>\n",
       "      <td>5.338285</td>\n",
       "      <td>5.775030</td>\n",
       "      <td>6.164638</td>\n",
       "      <td>6.243469</td>\n",
       "      <td>6.465160</td>\n",
       "      <td>7.252172</td>\n",
       "      <td>7.554743</td>\n",
       "      <td>...</td>\n",
       "      <td>6.365631</td>\n",
       "      <td>6.809607</td>\n",
       "      <td>6.171369</td>\n",
       "      <td>6.241722</td>\n",
       "      <td>7.921720</td>\n",
       "      <td>5.681363</td>\n",
       "      <td>6.398123</td>\n",
       "      <td>5.984258</td>\n",
       "      <td>7.232203</td>\n",
       "      <td>5.995213</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>S100A11</th>\n",
       "      <td>8.583035</td>\n",
       "      <td>11.111435</td>\n",
       "      <td>11.095424</td>\n",
       "      <td>11.263174</td>\n",
       "      <td>11.280444</td>\n",
       "      <td>10.653944</td>\n",
       "      <td>10.793425</td>\n",
       "      <td>10.604238</td>\n",
       "      <td>9.967588</td>\n",
       "      <td>7.924627</td>\n",
       "      <td>...</td>\n",
       "      <td>10.250471</td>\n",
       "      <td>9.668597</td>\n",
       "      <td>9.331145</td>\n",
       "      <td>9.691654</td>\n",
       "      <td>10.390032</td>\n",
       "      <td>10.651856</td>\n",
       "      <td>11.535622</td>\n",
       "      <td>8.926775</td>\n",
       "      <td>8.326074</td>\n",
       "      <td>10.674788</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>GADD45GIP1</th>\n",
       "      <td>8.659919</td>\n",
       "      <td>8.217836</td>\n",
       "      <td>8.003792</td>\n",
       "      <td>9.814658</td>\n",
       "      <td>8.498697</td>\n",
       "      <td>8.881745</td>\n",
       "      <td>9.213469</td>\n",
       "      <td>8.514755</td>\n",
       "      <td>9.138892</td>\n",
       "      <td>8.508368</td>\n",
       "      <td>...</td>\n",
       "      <td>8.083091</td>\n",
       "      <td>7.971706</td>\n",
       "      <td>8.717944</td>\n",
       "      <td>8.875915</td>\n",
       "      <td>8.415067</td>\n",
       "      <td>8.375225</td>\n",
       "      <td>8.002428</td>\n",
       "      <td>9.333611</td>\n",
       "      <td>8.210420</td>\n",
       "      <td>8.830827</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>ZNF382</th>\n",
       "      <td>5.378874</td>\n",
       "      <td>4.588003</td>\n",
       "      <td>4.310391</td>\n",
       "      <td>4.751397</td>\n",
       "      <td>6.638862</td>\n",
       "      <td>5.669832</td>\n",
       "      <td>5.675564</td>\n",
       "      <td>4.885011</td>\n",
       "      <td>6.202160</td>\n",
       "      <td>5.319530</td>\n",
       "      <td>...</td>\n",
       "      <td>4.603222</td>\n",
       "      <td>4.807792</td>\n",
       "      <td>4.692465</td>\n",
       "      <td>4.474601</td>\n",
       "      <td>5.696803</td>\n",
       "      <td>4.434532</td>\n",
       "      <td>5.538124</td>\n",
       "      <td>6.467458</td>\n",
       "      <td>5.567726</td>\n",
       "      <td>4.477378</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>DOK2</th>\n",
       "      <td>3.044298</td>\n",
       "      <td>3.059464</td>\n",
       "      <td>3.279239</td>\n",
       "      <td>3.140282</td>\n",
       "      <td>3.577542</td>\n",
       "      <td>3.336892</td>\n",
       "      <td>3.204914</td>\n",
       "      <td>3.225254</td>\n",
       "      <td>3.283722</td>\n",
       "      <td>3.396973</td>\n",
       "      <td>...</td>\n",
       "      <td>3.181542</td>\n",
       "      <td>3.276217</td>\n",
       "      <td>3.493929</td>\n",
       "      <td>3.423330</td>\n",
       "      <td>3.285180</td>\n",
       "      <td>3.419245</td>\n",
       "      <td>3.553555</td>\n",
       "      <td>3.450576</td>\n",
       "      <td>4.340967</td>\n",
       "      <td>3.359827</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>NAPEPLD</th>\n",
       "      <td>3.872128</td>\n",
       "      <td>4.082251</td>\n",
       "      <td>4.498936</td>\n",
       "      <td>4.456496</td>\n",
       "      <td>3.402218</td>\n",
       "      <td>3.767142</td>\n",
       "      <td>3.871012</td>\n",
       "      <td>5.560637</td>\n",
       "      <td>3.783922</td>\n",
       "      <td>4.475686</td>\n",
       "      <td>...</td>\n",
       "      <td>4.778300</td>\n",
       "      <td>3.890194</td>\n",
       "      <td>4.548519</td>\n",
       "      <td>3.650742</td>\n",
       "      <td>3.656010</td>\n",
       "      <td>4.171655</td>\n",
       "      <td>3.494903</td>\n",
       "      <td>4.351281</td>\n",
       "      <td>4.402933</td>\n",
       "      <td>3.855674</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>526 rows × 83 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                22RV1      647-V       A549   BFTC-905      BT-20     BT-474  \\\n",
       "ZYX          3.941590   5.204366   4.912069   4.664766   5.133911   4.941155   \n",
       "GADD45G      6.884257   2.816534   3.121235   3.297829   4.095581   6.002934   \n",
       "SASH1        4.296142   5.933057   4.261597   3.626372   6.256945   4.680919   \n",
       "MAP4K1       3.016747   3.040741   2.874760   3.005089   3.119357   3.428802   \n",
       "CST5         3.161125   3.372700   3.006167   3.060336   3.153971   3.465202   \n",
       "CADM3        3.314637   3.031378   3.178965   3.166439   3.291688   3.139113   \n",
       "SIRT2        5.239788   4.618523   5.333696   4.189891   6.008036   5.356842   \n",
       "RPL10        6.832162   6.870249   6.994830   5.960790   6.776642   7.536564   \n",
       "NF2          4.462146   4.915568   3.858324   4.342475   4.391052   4.046314   \n",
       "DKK1         6.325388   7.621139  12.122421  10.948822   4.157821   8.083121   \n",
       "SAFB2        6.247057   5.784535   5.362967   6.032035   5.334102   6.533180   \n",
       "JUP          7.441110   9.659033   9.375186   9.156500   8.329441   9.966623   \n",
       "GJA1         4.810230   3.326393   5.647902   4.225823   3.623304   3.263222   \n",
       "PLEKHO1      4.640663   4.590659   4.685167   4.428003   3.975914   4.319659   \n",
       "MAD1L1       5.485238   5.682445   4.111315   5.325992   5.161292   6.486319   \n",
       "ING5         3.833961   3.755047   3.788858   3.941058   3.844479   4.212456   \n",
       "BCL10        5.715067   6.610585   5.076287   6.707612   5.675817   5.084217   \n",
       "CAMTA1       4.498801   4.510983   4.580234   4.351539   4.584816   4.642158   \n",
       "GLIPR1       3.970460   6.020400   5.109596   4.622791   3.251677   3.355165   \n",
       "FH           9.534454   9.086597   8.419299   8.579138   9.333008   9.285310   \n",
       "TUSC2        6.299572   6.675912   6.083211   6.687928   6.581319   6.042204   \n",
       "ARID2        6.961399   5.603630   6.210514   5.675540   5.466854   5.899563   \n",
       "DLEC1        3.109465   2.907546   3.110925   2.934134   2.891672   3.102339   \n",
       "FOXO4        3.400629   3.567534   3.477594   3.372782   3.479097   3.533524   \n",
       "LIMD1        3.674656   3.421655   3.553268   3.210794   3.356882   3.483857   \n",
       "PRDM4        7.019736   7.005515   6.596734   7.348124   6.298713   7.584770   \n",
       "BMP10        3.084375   3.112843   3.028968   3.121645   3.104231   3.012876   \n",
       "IDH1        10.649014   8.314822   9.931359   8.697574  11.139695   8.352754   \n",
       "RBL1         3.473077   4.209457   3.450007   3.841721   3.702836   3.227963   \n",
       "ZFHX3        3.617820   4.434671   4.783307   4.039779   4.782089   4.742174   \n",
       "...               ...        ...        ...        ...        ...        ...   \n",
       "FOXP3        2.981604   2.985216   2.915779   3.057550   2.897542   3.097103   \n",
       "LXN          4.818783   3.280697  10.088517   3.224381   3.202445   6.690447   \n",
       "PARK2        3.199924   3.019583   3.139179   3.024695   3.078827   3.112272   \n",
       "PRKCDBP      3.089069   3.710405   3.695032   4.252051   3.420466   3.044450   \n",
       "IRF3         4.204523   4.723343   4.816416   4.649923   5.596047   4.949915   \n",
       "DDX3X        5.306141   6.203667   5.502748   5.594516   5.627455   5.395713   \n",
       "RB1          4.524552   3.096019   3.664309   3.731714   4.376842   3.503612   \n",
       "CHD5         3.192635   2.984700   3.076011   2.998725   2.897913   3.057982   \n",
       "PAX6         4.028073   3.807004   3.358637   4.094261   7.130923   2.972099   \n",
       "SFRP1        3.188761   3.231137   5.330982   3.041159   3.249385   3.276027   \n",
       "NDRG2        4.677503   3.486320   5.630512   3.900957   7.101863   5.069445   \n",
       "TMPRSS11A    2.870502   2.833078   2.735700   4.267372   2.823523   2.855180   \n",
       "PYHIN1       3.175882   2.905062   3.067200   3.092009   2.890412   3.071138   \n",
       "DFNA5        2.986476   8.676396   9.401452   8.007681   3.053527   3.123360   \n",
       "SMARCA2      7.990434   6.028194   5.571964   3.854994   7.516653   4.882019   \n",
       "SPRY2        5.602050   6.285734   7.042680   8.086614   6.170305   3.785336   \n",
       "BAX          5.969015   7.447411   7.982287   6.696344   6.679763   6.569358   \n",
       "IGF2R        7.573372   7.623085   6.956941   7.458472   6.841867   8.020542   \n",
       "PCDH10       2.982132   3.406444   3.173127   2.889307   3.000220   3.541436   \n",
       "PHLPP1       4.002743   3.666011   4.102836   3.775922   3.649520   3.989413   \n",
       "PAFAH1B1     7.884138   8.000928   8.313141   7.204942   7.677200   7.761747   \n",
       "DLEU2        2.676907   3.547069   2.787142   2.836224   3.227312   2.872764   \n",
       "E2F1         6.001907   5.983110   4.897051   5.070400   5.506922   5.591237   \n",
       "PALB2        6.276984   7.250447   6.948425   7.045179   7.356645   6.748739   \n",
       "FAM188A      7.737958   5.917429   6.112347   5.338285   5.775030   6.164638   \n",
       "S100A11      8.583035  11.111435  11.095424  11.263174  11.280444  10.653944   \n",
       "GADD45GIP1   8.659919   8.217836   8.003792   9.814658   8.498697   8.881745   \n",
       "ZNF382       5.378874   4.588003   4.310391   4.751397   6.638862   5.669832   \n",
       "DOK2         3.044298   3.059464   3.279239   3.140282   3.577542   3.336892   \n",
       "NAPEPLD      3.872128   4.082251   4.498936   4.456496   3.402218   3.767142   \n",
       "\n",
       "               BT-549        C32    CAL-120    CAL-148    ...          SW837  \\\n",
       "ZYX          5.655587   6.215595   4.415610   4.231359    ...       4.560421   \n",
       "GADD45G      2.820640   2.987849   2.758568   7.025054    ...       3.303425   \n",
       "SASH1        5.366439   6.963580   5.152033   5.823953    ...       5.439911   \n",
       "MAP4K1       2.970357   3.181064   2.941828   3.246280    ...       3.583015   \n",
       "CST5         3.225971   3.312577   2.990222   3.248122    ...       3.354106   \n",
       "CADM3        2.954189   3.345058   3.101887   3.749908    ...       3.279966   \n",
       "SIRT2        6.069756   6.456122   5.388351   5.613326    ...       4.765165   \n",
       "RPL10        7.961996   7.074002   6.763491   7.620725    ...       9.784303   \n",
       "NF2          4.549624   4.507336   5.372245   3.868760    ...       3.870313   \n",
       "DKK1         7.840029   3.226377  12.114559   9.266994    ...       6.712088   \n",
       "SAFB2        6.120087   5.897436   6.093817   5.776581    ...       5.317287   \n",
       "JUP          4.256758   3.856673   6.038497   8.184365    ...       9.812986   \n",
       "GJA1         5.719701   3.573138   3.600511   3.658770    ...       3.611492   \n",
       "PLEKHO1      7.770932   7.625111   5.563551   8.469644    ...       3.114768   \n",
       "MAD1L1       7.153442   9.474093   5.200431   5.371834    ...       5.503556   \n",
       "ING5         3.696306   3.546206   3.861259   4.149435    ...       4.289493   \n",
       "BCL10        6.733035   5.111526   5.374215   5.245943    ...       4.701158   \n",
       "CAMTA1       5.991350   5.122772   5.331344   5.364959    ...       4.863907   \n",
       "GLIPR1       8.267947   3.830908   4.439915   3.297260    ...       3.112195   \n",
       "FH           8.842696   8.244943   9.317453  10.068468    ...       8.531076   \n",
       "TUSC2        6.055383   6.324480   7.480025   6.742436    ...       5.054631   \n",
       "ARID2        5.757071   5.167250   5.239619   6.220964    ...       5.538160   \n",
       "DLEC1        3.035915   3.106742   2.887607   3.026003    ...       3.222723   \n",
       "FOXO4        3.316519   3.533678   3.501036   3.632969    ...       3.429158   \n",
       "LIMD1        3.514544   3.410297   3.366434   3.500823    ...       3.210965   \n",
       "PRDM4        6.834868   6.518273   6.491453   8.016437    ...       7.691132   \n",
       "BMP10        3.274657   2.958100   2.814362   3.210728    ...       3.232619   \n",
       "IDH1         7.541949   8.934956   7.349274   8.086308    ...       8.089019   \n",
       "RBL1         4.029079   3.600109   3.554048   3.910256    ...       3.786910   \n",
       "ZFHX3        4.255525   4.009081   3.902115   4.079719    ...       4.841286   \n",
       "...               ...        ...        ...        ...    ...            ...   \n",
       "FOXP3        2.887230   3.070364   2.947046   2.959116    ...       2.955591   \n",
       "LXN          3.367252   4.209321   7.984849   2.987428    ...       3.255701   \n",
       "PARK2        3.127635   3.136385   2.994945   3.279128    ...       3.119005   \n",
       "PRKCDBP      5.926926   6.331176   7.794936   3.046212    ...       4.990414   \n",
       "IRF3         4.497195   4.355670   6.457924   4.452737    ...       4.608323   \n",
       "DDX3X        4.674857   4.608957   5.788192   5.460773    ...       5.106087   \n",
       "RB1          3.266968   3.638497   3.471136   3.117782    ...       3.418880   \n",
       "CHD5         2.945381   2.829288   3.107214   3.226845    ...       3.013811   \n",
       "PAX6         6.339213   3.171753   3.762872   3.327210    ...       3.492099   \n",
       "SFRP1        4.025181   7.213512  12.452676   3.456186    ...       3.064195   \n",
       "NDRG2        3.445795   5.315459   3.798068   5.926873    ...       4.824400   \n",
       "TMPRSS11A    2.914614   2.861470   2.796175   2.904799    ...       2.980691   \n",
       "PYHIN1       2.990523   3.008619   2.949791   3.211010    ...       3.030422   \n",
       "DFNA5        7.748814   7.737281   7.391120   2.517137    ...       2.876618   \n",
       "SMARCA2      4.913034   5.722671   5.400255   7.194757    ...       5.219110   \n",
       "SPRY2        8.041924  10.164763   8.455994   5.062883    ...       5.079592   \n",
       "BAX          7.352075   7.870207   7.129632   7.091143    ...       7.278849   \n",
       "IGF2R        8.909259   8.821869   6.900228   8.274394    ...       8.144050   \n",
       "PCDH10       3.211485   2.989946   3.089691   2.967150    ...       2.963680   \n",
       "PHLPP1       3.982365   4.925186   3.548347   3.695069    ...       3.642714   \n",
       "PAFAH1B1     8.396872   7.858884   7.778578   7.629253    ...       7.295742   \n",
       "DLEU2        3.115254   2.842766   2.592059   2.936144    ...       2.524722   \n",
       "E2F1         5.757543   5.702826   5.529260   6.549320    ...       5.587431   \n",
       "PALB2        7.134663   6.155690   6.344497   8.088288    ...       7.671000   \n",
       "FAM188A      6.243469   6.465160   7.252172   7.554743    ...       6.365631   \n",
       "S100A11     10.793425  10.604238   9.967588   7.924627    ...      10.250471   \n",
       "GADD45GIP1   9.213469   8.514755   9.138892   8.508368    ...       8.083091   \n",
       "ZNF382       5.675564   4.885011   6.202160   5.319530    ...       4.603222   \n",
       "DOK2         3.204914   3.225254   3.283722   3.396973    ...       3.181542   \n",
       "NAPEPLD      3.871012   5.560637   3.783922   4.475686    ...       4.778300   \n",
       "\n",
       "                SW900     SW948       T-24       T47D     TCCSUP   UACC-812  \\\n",
       "ZYX          4.558872  5.163735   4.741197   3.921108   5.492629   4.283938   \n",
       "GADD45G      3.049742  3.727669   3.019107   4.108757   3.094141   5.361575   \n",
       "SASH1        4.513081  5.117161   5.817025   4.687558   5.393250   5.591640   \n",
       "MAP4K1       2.934833  3.087185   3.030658   3.203557   2.836363   3.105644   \n",
       "CST5         2.976170  3.359341   3.222965   3.214966   3.301471   3.366584   \n",
       "CADM3        3.152755  3.271687   3.140584   3.508587   3.295337   3.216208   \n",
       "SIRT2        4.797608  5.608583   4.777952   4.625962   4.590109   6.597426   \n",
       "RPL10        7.035165  6.628275   7.411194   6.081554   6.848690   7.067343   \n",
       "NF2          4.744224  3.910822   5.238765   4.147239   4.937637   4.246255   \n",
       "DKK1        10.716862  2.956745  11.130120  10.434384  11.225248   5.282694   \n",
       "SAFB2        5.647735  5.877850   5.450609   5.416330   5.402793   5.377506   \n",
       "JUP          8.338691  8.791620   7.626389   9.272512   7.231455   9.112013   \n",
       "GJA1         5.006607  3.376350   4.258637   3.617048   5.036670   3.661299   \n",
       "PLEKHO1      6.540184  3.895871   6.643725   4.181517   8.156359   5.346501   \n",
       "MAD1L1       4.679315  7.683906   6.269770   4.958479   5.003898   6.214460   \n",
       "ING5         3.582631  4.333733   3.733226   3.771620   3.596957   3.820713   \n",
       "BCL10        6.594262  5.657223   6.776556   5.270346   5.427207   5.346090   \n",
       "CAMTA1       4.687323  4.679047   4.632906   4.097423   4.472148   5.124919   \n",
       "GLIPR1       5.194062  4.135682   8.243753   3.458818   8.278484   3.205508   \n",
       "FH           8.945166  8.938430   9.227813   8.879167   9.488954   7.987016   \n",
       "TUSC2        6.484413  6.728647   6.002979   6.759734   6.597647   6.166636   \n",
       "ARID2        6.080444  5.986595   5.722316   6.286031   5.375532   4.674635   \n",
       "DLEC1        2.955758  3.095061   3.020308   3.161683   3.120874   3.021721   \n",
       "FOXO4        3.262394  3.666882   3.312882   3.461983   3.292221   4.035490   \n",
       "LIMD1        3.242277  3.583009   3.344055   3.108423   3.256021   3.076322   \n",
       "PRDM4        7.646865  7.323555   6.922357   6.792448   6.762302   7.096455   \n",
       "BMP10        3.085870  3.168334   3.103192   3.381826   3.280269   2.890558   \n",
       "IDH1         9.182878  9.734964   7.749971   8.256346   9.506883   8.513564   \n",
       "RBL1         3.711091  3.996105   4.372971   3.489254   4.825541   3.790818   \n",
       "ZFHX3        3.927599  3.891125   3.654787   3.472223   3.901307   3.638695   \n",
       "...               ...       ...        ...        ...        ...        ...   \n",
       "FOXP3        2.878231  3.020346   2.854790   3.114641   2.847317   2.931572   \n",
       "LXN          4.589068  7.106948   8.760514   3.288849   3.185465   4.172748   \n",
       "PARK2        3.140177  3.093932   3.071674   3.188115   3.097080   3.383873   \n",
       "PRKCDBP      4.768375  3.488477   9.369940   3.110815   3.461136   3.186216   \n",
       "IRF3         4.505271  4.256386   4.399739   4.153408   4.169489   4.684565   \n",
       "DDX3X        5.179408  5.071165   5.958953   5.190119   5.937856   5.667530   \n",
       "RB1          3.711499  4.529214   4.966209   3.823842   3.189678   4.140866   \n",
       "CHD5         3.045676  3.120130   3.119147   3.392055   3.069984   3.378481   \n",
       "PAX6         3.208120  4.985293   6.225009   3.140159   4.586031   3.189206   \n",
       "SFRP1        7.087948  3.430133   2.960842   3.206793   3.082273   3.230377   \n",
       "NDRG2        4.060437  7.035718   3.794874   5.348102   3.874384   5.506952   \n",
       "TMPRSS11A    2.914748  2.959246   2.902457   2.999052   2.855444   2.795403   \n",
       "PYHIN1       2.905128  3.086540   2.948810   2.953135   2.999250   3.234356   \n",
       "DFNA5        8.327849  2.890864   8.345326   3.198059   7.457824   3.139161   \n",
       "SMARCA2      6.374250  6.112657   5.679948   5.538017   6.124031   5.665645   \n",
       "SPRY2        8.171010  8.846313   7.051564   4.560252   7.500709   5.316408   \n",
       "BAX          6.945622  6.456304   7.187385   6.429532   7.421762   6.372965   \n",
       "IGF2R        8.166317  7.424834   7.464031   7.958298   9.105481   7.378177   \n",
       "PCDH10       3.095914  3.197740   2.994741   3.113202   3.607689   3.081531   \n",
       "PHLPP1       3.310469  4.359392   3.548311   3.623291   3.875227   4.185407   \n",
       "PAFAH1B1     8.349058  7.732011   7.986203   7.589771   7.832008   7.142825   \n",
       "DLEU2        2.498934  3.583962   3.281191   2.691534   3.158298   2.885179   \n",
       "E2F1         5.116335  5.872019   5.994388   4.672919   5.576714   4.618166   \n",
       "PALB2        6.838830  6.738839   7.207518   6.887917   7.821759   6.551294   \n",
       "FAM188A      6.809607  6.171369   6.241722   7.921720   5.681363   6.398123   \n",
       "S100A11      9.668597  9.331145   9.691654  10.390032  10.651856  11.535622   \n",
       "GADD45GIP1   7.971706  8.717944   8.875915   8.415067   8.375225   8.002428   \n",
       "ZNF382       4.807792  4.692465   4.474601   5.696803   4.434532   5.538124   \n",
       "DOK2         3.276217  3.493929   3.423330   3.285180   3.419245   3.553555   \n",
       "NAPEPLD      3.890194  4.548519   3.650742   3.656010   4.171655   3.494903   \n",
       "\n",
       "             UM-UC-3      VCaP   VM-CUB-1  \n",
       "ZYX         5.805750  4.355522   5.129551  \n",
       "GADD45G     3.093164  4.279718   3.209478  \n",
       "SASH1       4.734545  5.249760   5.337148  \n",
       "MAP4K1      2.856904  3.378733   3.032270  \n",
       "CST5        3.086696  2.919890   3.240980  \n",
       "CADM3       3.226101  3.545501   3.207830  \n",
       "SIRT2       4.590714  4.892502   4.796700  \n",
       "RPL10       7.041893  7.485062   7.221335  \n",
       "NF2         5.259157  4.263257   5.374764  \n",
       "DKK1        7.454326  2.767777  12.219899  \n",
       "SAFB2       6.160044  6.097196   6.195752  \n",
       "JUP         3.607236  7.893582   8.422437  \n",
       "GJA1        5.264573  3.266141   4.700218  \n",
       "PLEKHO1     5.879837  4.831115   5.403898  \n",
       "MAD1L1      4.335608  4.531748   5.809043  \n",
       "ING5        3.925415  4.218251   3.887065  \n",
       "BCL10       5.711474  4.422921   6.405497  \n",
       "CAMTA1      4.943213  5.018374   4.437826  \n",
       "GLIPR1      9.180804  3.512235   8.057524  \n",
       "FH          8.832687  8.883004   8.972795  \n",
       "TUSC2       6.386104  6.518322   6.755723  \n",
       "ARID2       6.652278  6.029322   5.498309  \n",
       "DLEC1       3.160895  3.168242   3.007760  \n",
       "FOXO4       3.358295  3.750215   3.231318  \n",
       "LIMD1       3.651217  3.542437   3.309383  \n",
       "PRDM4       7.493066  7.042053   6.968328  \n",
       "BMP10       3.418139  3.472125   3.086108  \n",
       "IDH1        7.540347  9.769079   8.046071  \n",
       "RBL1        3.648831  3.455339   4.903004  \n",
       "ZFHX3       3.396880  4.366164   3.352380  \n",
       "...              ...       ...        ...  \n",
       "FOXP3       3.090450  2.931465   2.756575  \n",
       "LXN         3.218839  6.674011   4.109363  \n",
       "PARK2       3.191161  3.304525   3.145199  \n",
       "PRKCDBP     6.821806  3.447177   6.615427  \n",
       "IRF3        4.282969  4.243448   4.870604  \n",
       "DDX3X       4.753125  5.258761   5.891738  \n",
       "RB1         4.403053  3.301463   4.279524  \n",
       "CHD5        3.262041  3.315252   3.109847  \n",
       "PAX6        4.630888  3.300330   5.230359  \n",
       "SFRP1       4.047380  3.671804   3.130926  \n",
       "NDRG2       4.149994  6.128871   4.154323  \n",
       "TMPRSS11A   2.965562  2.971710   2.923276  \n",
       "PYHIN1      3.142873  3.277236   2.899782  \n",
       "DFNA5       7.746453  3.156094   7.551902  \n",
       "SMARCA2     5.771700  7.663862   5.523442  \n",
       "SPRY2       8.603669  4.966854   6.273701  \n",
       "BAX         7.637897  6.117035   7.539109  \n",
       "IGF2R       7.445280  6.781037   7.428893  \n",
       "PCDH10      3.542770  3.097435   3.117340  \n",
       "PHLPP1      3.539272  3.901840   3.910575  \n",
       "PAFAH1B1    8.433927  7.990676   7.939682  \n",
       "DLEU2       3.224540  2.767189   3.510358  \n",
       "E2F1        4.508136  5.472550   5.805323  \n",
       "PALB2       6.681040  5.669767   7.502697  \n",
       "FAM188A     5.984258  7.232203   5.995213  \n",
       "S100A11     8.926775  8.326074  10.674788  \n",
       "GADD45GIP1  9.333611  8.210420   8.830827  \n",
       "ZNF382      6.467458  5.567726   4.477378  \n",
       "DOK2        3.450576  4.340967   3.359827  \n",
       "NAPEPLD     4.351281  4.402933   3.855674  \n",
       "\n",
       "[526 rows x 83 columns]"
      ]
     },
     "execution_count": 95,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "ts = set(ts_genes) & set(gex.index)\n",
    "tsgex = gex.loc[ts]\n",
    "tsgex"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 99,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "(37, 83)"
      ]
     },
     "execution_count": 99,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "for tsg in tsgex.index:\n",
    "    row = tsgex.loc[tsg]\n",
    "    upper = np.mean(row) + 6*np.std(row)\n",
    "    lower = np.mean(row) - 6*np.std(row)\n",
    "    \n",
    "    if not (any(row > upper) or any(row < lower)):\n",
    "        tsgex.drop(tsg, inplace=True)\n",
    "tsgex.shape"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 107,
   "metadata": {
    "collapsed": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>CELL_LINE</th>\n",
       "      <th>COMPOUND_A</th>\n",
       "      <th>COMPOUND_B</th>\n",
       "      <th>MAX_CONC_A</th>\n",
       "      <th>MAX_CONC_B</th>\n",
       "      <th>IC50_A</th>\n",
       "      <th>H_A</th>\n",
       "      <th>Einf_A</th>\n",
       "      <th>IC50_B</th>\n",
       "      <th>H_B</th>\n",
       "      <th>...</th>\n",
       "      <th>SCGB3A1</th>\n",
       "      <th>PLXNC1</th>\n",
       "      <th>ZMYND10</th>\n",
       "      <th>RASSF2</th>\n",
       "      <th>PAEP</th>\n",
       "      <th>DMBT1</th>\n",
       "      <th>SLC5A8</th>\n",
       "      <th>CHD5</th>\n",
       "      <th>TMPRSS11A</th>\n",
       "      <th>PCDH10</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>1120</th>\n",
       "      <td>NCI-H226</td>\n",
       "      <td>CarboTaxol</td>\n",
       "      <td>CSNK2A1_2</td>\n",
       "      <td>0.10</td>\n",
       "      <td>0.01</td>\n",
       "      <td>0.004267</td>\n",
       "      <td>1.957945</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.001606</td>\n",
       "      <td>3.191878</td>\n",
       "      <td>...</td>\n",
       "      <td>3.196587</td>\n",
       "      <td>3.105170</td>\n",
       "      <td>2.758353</td>\n",
       "      <td>2.904278</td>\n",
       "      <td>3.244633</td>\n",
       "      <td>3.106455</td>\n",
       "      <td>2.967927</td>\n",
       "      <td>3.017443</td>\n",
       "      <td>3.012289</td>\n",
       "      <td>3.069359</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>869</th>\n",
       "      <td>MDA-MB-157</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.037093</td>\n",
       "      <td>2.848411</td>\n",
       "      <td>38.622217</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.417108</td>\n",
       "      <td>2.848206</td>\n",
       "      <td>3.142725</td>\n",
       "      <td>2.936310</td>\n",
       "      <td>3.007921</td>\n",
       "      <td>3.054710</td>\n",
       "      <td>2.756604</td>\n",
       "      <td>3.424931</td>\n",
       "      <td>2.837982</td>\n",
       "      <td>3.256840</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>282</th>\n",
       "      <td>CAL-120</td>\n",
       "      <td>AKT</td>\n",
       "      <td>PIK3C_2</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>62.600248</td>\n",
       "      <td>0.244725</td>\n",
       "      <td>2.877772</td>\n",
       "      <td>...</td>\n",
       "      <td>3.034160</td>\n",
       "      <td>2.935529</td>\n",
       "      <td>3.573663</td>\n",
       "      <td>2.876825</td>\n",
       "      <td>3.128143</td>\n",
       "      <td>3.035675</td>\n",
       "      <td>2.835125</td>\n",
       "      <td>3.107214</td>\n",
       "      <td>2.796175</td>\n",
       "      <td>3.089691</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>660</th>\n",
       "      <td>MDA-MB-231</td>\n",
       "      <td>ATR_4</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.757933</td>\n",
       "      <td>1.701477</td>\n",
       "      <td>0.972413</td>\n",
       "      <td>9.996671</td>\n",
       "      <td>...</td>\n",
       "      <td>3.181619</td>\n",
       "      <td>3.926466</td>\n",
       "      <td>2.869493</td>\n",
       "      <td>3.546421</td>\n",
       "      <td>2.951307</td>\n",
       "      <td>3.182094</td>\n",
       "      <td>2.956081</td>\n",
       "      <td>3.136598</td>\n",
       "      <td>2.861495</td>\n",
       "      <td>3.060358</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1923</th>\n",
       "      <td>HCC38</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>SLC16A4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.241770</td>\n",
       "      <td>4.489731</td>\n",
       "      <td>...</td>\n",
       "      <td>2.917921</td>\n",
       "      <td>2.905185</td>\n",
       "      <td>2.619804</td>\n",
       "      <td>2.898116</td>\n",
       "      <td>3.195140</td>\n",
       "      <td>3.023079</td>\n",
       "      <td>2.750002</td>\n",
       "      <td>3.248283</td>\n",
       "      <td>2.824575</td>\n",
       "      <td>3.479549</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>671</th>\n",
       "      <td>DMS-114</td>\n",
       "      <td>ATR_4</td>\n",
       "      <td>CarboTaxol</td>\n",
       "      <td>0.01</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.001789</td>\n",
       "      <td>2.931865</td>\n",
       "      <td>10.639634</td>\n",
       "      <td>1.060265</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.108994</td>\n",
       "      <td>2.900969</td>\n",
       "      <td>3.393863</td>\n",
       "      <td>3.532048</td>\n",
       "      <td>2.939697</td>\n",
       "      <td>3.020590</td>\n",
       "      <td>2.719290</td>\n",
       "      <td>4.446063</td>\n",
       "      <td>2.762481</td>\n",
       "      <td>3.215187</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1389</th>\n",
       "      <td>KU-19-19</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>56.600823</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.971459</td>\n",
       "      <td>3.787799</td>\n",
       "      <td>2.994033</td>\n",
       "      <td>3.091832</td>\n",
       "      <td>3.257342</td>\n",
       "      <td>3.143533</td>\n",
       "      <td>2.988031</td>\n",
       "      <td>3.292097</td>\n",
       "      <td>2.752586</td>\n",
       "      <td>3.111552</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2039</th>\n",
       "      <td>BFTC-905</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>PIM1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>0.337757</td>\n",
       "      <td>80.476441</td>\n",
       "      <td>1.453983</td>\n",
       "      <td>0.795855</td>\n",
       "      <td>...</td>\n",
       "      <td>3.008259</td>\n",
       "      <td>2.942337</td>\n",
       "      <td>2.777214</td>\n",
       "      <td>2.799285</td>\n",
       "      <td>3.048194</td>\n",
       "      <td>3.259930</td>\n",
       "      <td>2.902307</td>\n",
       "      <td>2.998725</td>\n",
       "      <td>4.267372</td>\n",
       "      <td>2.889307</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>520</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>AKT_SGK</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.305450</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>20.899430</td>\n",
       "      <td>0.339596</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.077701</td>\n",
       "      <td>3.158744</td>\n",
       "      <td>2.937235</td>\n",
       "      <td>2.997616</td>\n",
       "      <td>3.063270</td>\n",
       "      <td>3.105196</td>\n",
       "      <td>2.987275</td>\n",
       "      <td>3.032658</td>\n",
       "      <td>2.863135</td>\n",
       "      <td>3.115976</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>784</th>\n",
       "      <td>SW620</td>\n",
       "      <td>BCL2</td>\n",
       "      <td>IGFR_4</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.30</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>1.618277</td>\n",
       "      <td>43.744349</td>\n",
       "      <td>0.002947</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.051775</td>\n",
       "      <td>3.345778</td>\n",
       "      <td>2.891563</td>\n",
       "      <td>2.985521</td>\n",
       "      <td>3.041921</td>\n",
       "      <td>3.626924</td>\n",
       "      <td>2.963113</td>\n",
       "      <td>3.179157</td>\n",
       "      <td>2.959542</td>\n",
       "      <td>3.041055</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1873</th>\n",
       "      <td>T47D</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.166243</td>\n",
       "      <td>0.978454</td>\n",
       "      <td>11.286392</td>\n",
       "      <td>0.014740</td>\n",
       "      <td>0.925424</td>\n",
       "      <td>...</td>\n",
       "      <td>3.529014</td>\n",
       "      <td>2.963293</td>\n",
       "      <td>5.392502</td>\n",
       "      <td>2.947590</td>\n",
       "      <td>2.966073</td>\n",
       "      <td>3.279402</td>\n",
       "      <td>2.932696</td>\n",
       "      <td>3.392055</td>\n",
       "      <td>2.999052</td>\n",
       "      <td>3.113202</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1111</th>\n",
       "      <td>A549</td>\n",
       "      <td>CarboTaxol</td>\n",
       "      <td>CSNK2A1_2</td>\n",
       "      <td>0.10</td>\n",
       "      <td>0.01</td>\n",
       "      <td>0.015534</td>\n",
       "      <td>4.405409</td>\n",
       "      <td>7.787490</td>\n",
       "      <td>0.002395</td>\n",
       "      <td>5.267135</td>\n",
       "      <td>...</td>\n",
       "      <td>2.618201</td>\n",
       "      <td>3.439598</td>\n",
       "      <td>2.871481</td>\n",
       "      <td>4.590143</td>\n",
       "      <td>3.229038</td>\n",
       "      <td>3.175361</td>\n",
       "      <td>2.883676</td>\n",
       "      <td>3.076011</td>\n",
       "      <td>2.735700</td>\n",
       "      <td>3.173127</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1499</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>FASN</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.081707</td>\n",
       "      <td>3.042215</td>\n",
       "      <td>81.184951</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.999705</td>\n",
       "      <td>2.747906</td>\n",
       "      <td>3.610392</td>\n",
       "      <td>3.089765</td>\n",
       "      <td>3.152753</td>\n",
       "      <td>3.512786</td>\n",
       "      <td>3.080372</td>\n",
       "      <td>3.226845</td>\n",
       "      <td>2.904799</td>\n",
       "      <td>2.967150</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>551</th>\n",
       "      <td>NCI-H23</td>\n",
       "      <td>ALK</td>\n",
       "      <td>EGFR_2</td>\n",
       "      <td>1.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.000100</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>80.738188</td>\n",
       "      <td>0.048314</td>\n",
       "      <td>0.996378</td>\n",
       "      <td>...</td>\n",
       "      <td>3.105895</td>\n",
       "      <td>3.064982</td>\n",
       "      <td>2.980468</td>\n",
       "      <td>3.382724</td>\n",
       "      <td>2.782616</td>\n",
       "      <td>3.244990</td>\n",
       "      <td>3.046582</td>\n",
       "      <td>3.299269</td>\n",
       "      <td>2.910972</td>\n",
       "      <td>3.186866</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>807</th>\n",
       "      <td>NCI-H1975</td>\n",
       "      <td>BCL2</td>\n",
       "      <td>Topotecan</td>\n",
       "      <td>1.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.170760</td>\n",
       "      <td>3.460592</td>\n",
       "      <td>25.019012</td>\n",
       "      <td>0.797019</td>\n",
       "      <td>2.260090</td>\n",
       "      <td>...</td>\n",
       "      <td>2.889549</td>\n",
       "      <td>3.388011</td>\n",
       "      <td>2.653350</td>\n",
       "      <td>3.004391</td>\n",
       "      <td>5.483910</td>\n",
       "      <td>3.127484</td>\n",
       "      <td>2.966180</td>\n",
       "      <td>3.039337</td>\n",
       "      <td>2.945612</td>\n",
       "      <td>3.032989</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1638</th>\n",
       "      <td>MCF7</td>\n",
       "      <td>HSP90</td>\n",
       "      <td>PARP1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.402211</td>\n",
       "      <td>2.172594</td>\n",
       "      <td>78.262462</td>\n",
       "      <td>0.036303</td>\n",
       "      <td>2.611075</td>\n",
       "      <td>...</td>\n",
       "      <td>2.810044</td>\n",
       "      <td>3.138420</td>\n",
       "      <td>3.121148</td>\n",
       "      <td>3.285233</td>\n",
       "      <td>3.020808</td>\n",
       "      <td>3.418069</td>\n",
       "      <td>2.947500</td>\n",
       "      <td>3.102655</td>\n",
       "      <td>3.003778</td>\n",
       "      <td>3.026654</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>515</th>\n",
       "      <td>MFM-223</td>\n",
       "      <td>AKT_SGK</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.183281</td>\n",
       "      <td>92.498101</td>\n",
       "      <td>0.159500</td>\n",
       "      <td>1.360827</td>\n",
       "      <td>...</td>\n",
       "      <td>3.074193</td>\n",
       "      <td>3.119683</td>\n",
       "      <td>2.852664</td>\n",
       "      <td>2.831212</td>\n",
       "      <td>3.331895</td>\n",
       "      <td>3.090648</td>\n",
       "      <td>2.909637</td>\n",
       "      <td>2.904436</td>\n",
       "      <td>2.918381</td>\n",
       "      <td>3.036467</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1371</th>\n",
       "      <td>VM-CUB-1</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.295627</td>\n",
       "      <td>1.207419</td>\n",
       "      <td>74.800075</td>\n",
       "      <td>0.000300</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.763581</td>\n",
       "      <td>3.058533</td>\n",
       "      <td>2.941588</td>\n",
       "      <td>2.954028</td>\n",
       "      <td>3.242681</td>\n",
       "      <td>3.381658</td>\n",
       "      <td>3.162877</td>\n",
       "      <td>3.109847</td>\n",
       "      <td>2.923276</td>\n",
       "      <td>3.117340</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>196</th>\n",
       "      <td>NCI-H1703</td>\n",
       "      <td>AKT</td>\n",
       "      <td>CSNK2A1_2</td>\n",
       "      <td>0.10</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.010633</td>\n",
       "      <td>3.211180</td>\n",
       "      <td>11.333820</td>\n",
       "      <td>0.006865</td>\n",
       "      <td>0.663950</td>\n",
       "      <td>...</td>\n",
       "      <td>3.100216</td>\n",
       "      <td>2.796563</td>\n",
       "      <td>3.050630</td>\n",
       "      <td>3.922159</td>\n",
       "      <td>2.992315</td>\n",
       "      <td>3.186393</td>\n",
       "      <td>2.943426</td>\n",
       "      <td>3.154295</td>\n",
       "      <td>2.990087</td>\n",
       "      <td>7.430479</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1798</th>\n",
       "      <td>SW900</td>\n",
       "      <td>IAP</td>\n",
       "      <td>Vinorelbine</td>\n",
       "      <td>0.10</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.019645</td>\n",
       "      <td>2.972307</td>\n",
       "      <td>32.862210</td>\n",
       "      <td>2.078708</td>\n",
       "      <td>0.160256</td>\n",
       "      <td>...</td>\n",
       "      <td>3.000264</td>\n",
       "      <td>3.359064</td>\n",
       "      <td>2.677600</td>\n",
       "      <td>3.275909</td>\n",
       "      <td>3.593650</td>\n",
       "      <td>3.113598</td>\n",
       "      <td>2.751693</td>\n",
       "      <td>3.045676</td>\n",
       "      <td>2.914748</td>\n",
       "      <td>3.095914</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1466</th>\n",
       "      <td>HCC1954</td>\n",
       "      <td>ESR1_1</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.979539</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>20.398874</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>1.800982</td>\n",
       "      <td>...</td>\n",
       "      <td>2.808530</td>\n",
       "      <td>2.813112</td>\n",
       "      <td>2.820790</td>\n",
       "      <td>2.840546</td>\n",
       "      <td>2.949892</td>\n",
       "      <td>3.620413</td>\n",
       "      <td>2.817355</td>\n",
       "      <td>3.242901</td>\n",
       "      <td>2.894186</td>\n",
       "      <td>3.033169</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2131</th>\n",
       "      <td>DU-4475</td>\n",
       "      <td>PIK3CB_PIK3CD</td>\n",
       "      <td>TNKS_PARP6</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.018177</td>\n",
       "      <td>2.918650</td>\n",
       "      <td>2.525304</td>\n",
       "      <td>0.186303</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>6.641317</td>\n",
       "      <td>3.261940</td>\n",
       "      <td>2.967371</td>\n",
       "      <td>2.931512</td>\n",
       "      <td>2.738748</td>\n",
       "      <td>3.018776</td>\n",
       "      <td>2.882149</td>\n",
       "      <td>2.963330</td>\n",
       "      <td>2.896696</td>\n",
       "      <td>3.053156</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1470</th>\n",
       "      <td>MDA-MB-453</td>\n",
       "      <td>ESR1_1</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>1.074279</td>\n",
       "      <td>1.380102</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>1.267985</td>\n",
       "      <td>...</td>\n",
       "      <td>3.339377</td>\n",
       "      <td>2.929715</td>\n",
       "      <td>3.101365</td>\n",
       "      <td>3.071616</td>\n",
       "      <td>2.979513</td>\n",
       "      <td>3.920466</td>\n",
       "      <td>2.819317</td>\n",
       "      <td>2.917080</td>\n",
       "      <td>2.780886</td>\n",
       "      <td>3.151810</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1324</th>\n",
       "      <td>HCC1395</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.009375</td>\n",
       "      <td>1.413786</td>\n",
       "      <td>47.213513</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.321879</td>\n",
       "      <td>...</td>\n",
       "      <td>3.335179</td>\n",
       "      <td>3.120729</td>\n",
       "      <td>2.840833</td>\n",
       "      <td>2.996178</td>\n",
       "      <td>2.762244</td>\n",
       "      <td>3.262841</td>\n",
       "      <td>2.914026</td>\n",
       "      <td>2.998041</td>\n",
       "      <td>2.995132</td>\n",
       "      <td>4.135256</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>531</th>\n",
       "      <td>NCI-H1437</td>\n",
       "      <td>ALK</td>\n",
       "      <td>CSNK2A1_2</td>\n",
       "      <td>0.10</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.009940</td>\n",
       "      <td>1.991152</td>\n",
       "      <td>8.494214</td>\n",
       "      <td>0.763935</td>\n",
       "      <td>0.964060</td>\n",
       "      <td>...</td>\n",
       "      <td>3.130618</td>\n",
       "      <td>3.165875</td>\n",
       "      <td>2.975913</td>\n",
       "      <td>3.229888</td>\n",
       "      <td>3.244565</td>\n",
       "      <td>3.249300</td>\n",
       "      <td>3.136237</td>\n",
       "      <td>3.121637</td>\n",
       "      <td>2.910373</td>\n",
       "      <td>3.226794</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>684</th>\n",
       "      <td>NCI-H2291</td>\n",
       "      <td>ATR_4</td>\n",
       "      <td>CarboTaxol</td>\n",
       "      <td>0.30</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.004500</td>\n",
       "      <td>1.112722</td>\n",
       "      <td>53.213744</td>\n",
       "      <td>1.307301</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.045388</td>\n",
       "      <td>3.425525</td>\n",
       "      <td>2.927099</td>\n",
       "      <td>2.969691</td>\n",
       "      <td>3.247989</td>\n",
       "      <td>3.064667</td>\n",
       "      <td>2.981434</td>\n",
       "      <td>3.220535</td>\n",
       "      <td>2.950242</td>\n",
       "      <td>3.071855</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>777</th>\n",
       "      <td>NCI-H520</td>\n",
       "      <td>BCL2</td>\n",
       "      <td>CSNK2A1_2</td>\n",
       "      <td>0.03</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.007215</td>\n",
       "      <td>1.601308</td>\n",
       "      <td>15.403837</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.192131</td>\n",
       "      <td>3.342862</td>\n",
       "      <td>3.071031</td>\n",
       "      <td>3.045198</td>\n",
       "      <td>3.012284</td>\n",
       "      <td>3.227953</td>\n",
       "      <td>3.022355</td>\n",
       "      <td>3.016550</td>\n",
       "      <td>2.949874</td>\n",
       "      <td>3.013212</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1005</th>\n",
       "      <td>CAMA-1</td>\n",
       "      <td>BCL2L1</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>1.192237</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>31.293248</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.929818</td>\n",
       "      <td>3.257416</td>\n",
       "      <td>2.998274</td>\n",
       "      <td>2.953413</td>\n",
       "      <td>3.029040</td>\n",
       "      <td>3.226411</td>\n",
       "      <td>4.161931</td>\n",
       "      <td>3.143544</td>\n",
       "      <td>2.863846</td>\n",
       "      <td>3.028737</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1684</th>\n",
       "      <td>VM-CUB-1</td>\n",
       "      <td>IAP</td>\n",
       "      <td>PARP1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.03</td>\n",
       "      <td>0.152387</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>86.021772</td>\n",
       "      <td>0.004546</td>\n",
       "      <td>2.540027</td>\n",
       "      <td>...</td>\n",
       "      <td>2.763581</td>\n",
       "      <td>3.058533</td>\n",
       "      <td>2.941588</td>\n",
       "      <td>2.954028</td>\n",
       "      <td>3.242681</td>\n",
       "      <td>3.381658</td>\n",
       "      <td>3.162877</td>\n",
       "      <td>3.109847</td>\n",
       "      <td>2.923276</td>\n",
       "      <td>3.117340</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>965</th>\n",
       "      <td>NCI-H2170</td>\n",
       "      <td>BCL2L1</td>\n",
       "      <td>CarboTaxol</td>\n",
       "      <td>0.01</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.002673</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>7.697676</td>\n",
       "      <td>0.346608</td>\n",
       "      <td>1.066233</td>\n",
       "      <td>...</td>\n",
       "      <td>3.249636</td>\n",
       "      <td>3.055646</td>\n",
       "      <td>3.134305</td>\n",
       "      <td>2.850209</td>\n",
       "      <td>3.757147</td>\n",
       "      <td>3.094029</td>\n",
       "      <td>3.034178</td>\n",
       "      <td>3.061812</td>\n",
       "      <td>3.131563</td>\n",
       "      <td>3.063637</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1240</th>\n",
       "      <td>NCI-H2228</td>\n",
       "      <td>CSNK2A1_2</td>\n",
       "      <td>TNFSF10</td>\n",
       "      <td>0.03</td>\n",
       "      <td>0.10</td>\n",
       "      <td>0.008426</td>\n",
       "      <td>2.269674</td>\n",
       "      <td>33.221896</td>\n",
       "      <td>0.027232</td>\n",
       "      <td>0.687339</td>\n",
       "      <td>...</td>\n",
       "      <td>2.815644</td>\n",
       "      <td>3.691472</td>\n",
       "      <td>2.871655</td>\n",
       "      <td>2.853733</td>\n",
       "      <td>3.231701</td>\n",
       "      <td>2.913922</td>\n",
       "      <td>2.801132</td>\n",
       "      <td>2.967801</td>\n",
       "      <td>2.843641</td>\n",
       "      <td>2.940855</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1604</th>\n",
       "      <td>KU-19-19</td>\n",
       "      <td>Gemcitabine</td>\n",
       "      <td>PARP1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.10</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.003773</td>\n",
       "      <td>2.510380</td>\n",
       "      <td>...</td>\n",
       "      <td>2.971459</td>\n",
       "      <td>3.787799</td>\n",
       "      <td>2.994033</td>\n",
       "      <td>3.091832</td>\n",
       "      <td>3.257342</td>\n",
       "      <td>3.143533</td>\n",
       "      <td>2.988031</td>\n",
       "      <td>3.292097</td>\n",
       "      <td>2.752586</td>\n",
       "      <td>3.111552</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1270</th>\n",
       "      <td>NCI-H23</td>\n",
       "      <td>Doxorubicin</td>\n",
       "      <td>TOP2</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.10</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>0.874108</td>\n",
       "      <td>20.708785</td>\n",
       "      <td>0.015070</td>\n",
       "      <td>1.003054</td>\n",
       "      <td>...</td>\n",
       "      <td>3.105895</td>\n",
       "      <td>3.064982</td>\n",
       "      <td>2.980468</td>\n",
       "      <td>3.382724</td>\n",
       "      <td>2.782616</td>\n",
       "      <td>3.244990</td>\n",
       "      <td>3.046582</td>\n",
       "      <td>3.299269</td>\n",
       "      <td>2.910972</td>\n",
       "      <td>3.186866</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1332</th>\n",
       "      <td>M14</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.199644</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.933039</td>\n",
       "      <td>6.518348</td>\n",
       "      <td>2.922837</td>\n",
       "      <td>3.023487</td>\n",
       "      <td>3.168739</td>\n",
       "      <td>3.119093</td>\n",
       "      <td>3.526466</td>\n",
       "      <td>3.000046</td>\n",
       "      <td>2.837732</td>\n",
       "      <td>2.966951</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1867</th>\n",
       "      <td>MDA-MB-453</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.927035</td>\n",
       "      <td>1.562516</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>1.489434</td>\n",
       "      <td>...</td>\n",
       "      <td>3.339377</td>\n",
       "      <td>2.929715</td>\n",
       "      <td>3.101365</td>\n",
       "      <td>3.071616</td>\n",
       "      <td>2.979513</td>\n",
       "      <td>3.920466</td>\n",
       "      <td>2.819317</td>\n",
       "      <td>2.917080</td>\n",
       "      <td>2.780886</td>\n",
       "      <td>3.151810</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>226</th>\n",
       "      <td>HCC1419</td>\n",
       "      <td>AKT</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.140781</td>\n",
       "      <td>1.101064</td>\n",
       "      <td>18.453283</td>\n",
       "      <td>0.623293</td>\n",
       "      <td>0.564782</td>\n",
       "      <td>...</td>\n",
       "      <td>3.143145</td>\n",
       "      <td>3.051578</td>\n",
       "      <td>3.167154</td>\n",
       "      <td>2.695011</td>\n",
       "      <td>3.283737</td>\n",
       "      <td>3.176259</td>\n",
       "      <td>2.946651</td>\n",
       "      <td>2.895803</td>\n",
       "      <td>2.869254</td>\n",
       "      <td>3.024603</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>830</th>\n",
       "      <td>CAL-51</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>0.10</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.000822</td>\n",
       "      <td>6.824547</td>\n",
       "      <td>93.050346</td>\n",
       "      <td>0.181424</td>\n",
       "      <td>0.985490</td>\n",
       "      <td>...</td>\n",
       "      <td>2.802066</td>\n",
       "      <td>2.971389</td>\n",
       "      <td>2.716059</td>\n",
       "      <td>2.798442</td>\n",
       "      <td>3.483779</td>\n",
       "      <td>3.031597</td>\n",
       "      <td>2.639684</td>\n",
       "      <td>2.951518</td>\n",
       "      <td>2.736339</td>\n",
       "      <td>2.880854</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>815</th>\n",
       "      <td>HCC1187</td>\n",
       "      <td>BCL2_2</td>\n",
       "      <td>EGFR_2</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.453242</td>\n",
       "      <td>2.806844</td>\n",
       "      <td>2.906644</td>\n",
       "      <td>3.273166</td>\n",
       "      <td>3.164783</td>\n",
       "      <td>3.285630</td>\n",
       "      <td>2.926218</td>\n",
       "      <td>3.041712</td>\n",
       "      <td>2.839010</td>\n",
       "      <td>3.042895</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>421</th>\n",
       "      <td>HCC1143</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>ESR1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>0.168050</td>\n",
       "      <td>0.843434</td>\n",
       "      <td>...</td>\n",
       "      <td>2.919405</td>\n",
       "      <td>2.929893</td>\n",
       "      <td>2.804370</td>\n",
       "      <td>3.004955</td>\n",
       "      <td>3.174471</td>\n",
       "      <td>3.134975</td>\n",
       "      <td>2.728687</td>\n",
       "      <td>3.255077</td>\n",
       "      <td>2.752513</td>\n",
       "      <td>2.999672</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>408</th>\n",
       "      <td>HCC1419</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>EGFR_2</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.528474</td>\n",
       "      <td>1.524840</td>\n",
       "      <td>36.904572</td>\n",
       "      <td>0.132235</td>\n",
       "      <td>1.014869</td>\n",
       "      <td>...</td>\n",
       "      <td>3.143145</td>\n",
       "      <td>3.051578</td>\n",
       "      <td>3.167154</td>\n",
       "      <td>2.695011</td>\n",
       "      <td>3.283737</td>\n",
       "      <td>3.176259</td>\n",
       "      <td>2.946651</td>\n",
       "      <td>2.895803</td>\n",
       "      <td>2.869254</td>\n",
       "      <td>3.024603</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>136</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>AKT</td>\n",
       "      <td>ATR_4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.510325</td>\n",
       "      <td>2.634897</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>1.991181</td>\n",
       "      <td>...</td>\n",
       "      <td>3.077701</td>\n",
       "      <td>3.158744</td>\n",
       "      <td>2.937235</td>\n",
       "      <td>2.997616</td>\n",
       "      <td>3.063270</td>\n",
       "      <td>3.105196</td>\n",
       "      <td>2.987275</td>\n",
       "      <td>3.032658</td>\n",
       "      <td>2.863135</td>\n",
       "      <td>3.115976</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>581</th>\n",
       "      <td>DMS-114</td>\n",
       "      <td>ALK_2</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.151997</td>\n",
       "      <td>1.179879</td>\n",
       "      <td>13.464204</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>0.470659</td>\n",
       "      <td>...</td>\n",
       "      <td>3.108994</td>\n",
       "      <td>2.900969</td>\n",
       "      <td>3.393863</td>\n",
       "      <td>3.532048</td>\n",
       "      <td>2.939697</td>\n",
       "      <td>3.020590</td>\n",
       "      <td>2.719290</td>\n",
       "      <td>4.446063</td>\n",
       "      <td>2.762481</td>\n",
       "      <td>3.215187</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>257</th>\n",
       "      <td>KMS-11</td>\n",
       "      <td>AKT</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>0.03</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.030000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>28.201761</td>\n",
       "      <td>1.078691</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.216024</td>\n",
       "      <td>3.765180</td>\n",
       "      <td>3.107443</td>\n",
       "      <td>3.219757</td>\n",
       "      <td>3.416491</td>\n",
       "      <td>3.210491</td>\n",
       "      <td>2.970834</td>\n",
       "      <td>3.027391</td>\n",
       "      <td>2.817485</td>\n",
       "      <td>3.439833</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>796</th>\n",
       "      <td>RKO</td>\n",
       "      <td>BCL2</td>\n",
       "      <td>Oxaliplatin</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>2.782220</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.028861</td>\n",
       "      <td>1.471660</td>\n",
       "      <td>...</td>\n",
       "      <td>3.285907</td>\n",
       "      <td>3.318851</td>\n",
       "      <td>2.833059</td>\n",
       "      <td>3.042848</td>\n",
       "      <td>3.152022</td>\n",
       "      <td>3.203563</td>\n",
       "      <td>3.015670</td>\n",
       "      <td>3.216483</td>\n",
       "      <td>2.896112</td>\n",
       "      <td>2.992803</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1596</th>\n",
       "      <td>KMS-11</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>WNT</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.03</td>\n",
       "      <td>1.035844</td>\n",
       "      <td>1.615199</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>0.030000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.216024</td>\n",
       "      <td>3.765180</td>\n",
       "      <td>3.107443</td>\n",
       "      <td>3.219757</td>\n",
       "      <td>3.416491</td>\n",
       "      <td>3.210491</td>\n",
       "      <td>2.970834</td>\n",
       "      <td>3.027391</td>\n",
       "      <td>2.817485</td>\n",
       "      <td>3.439833</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1709</th>\n",
       "      <td>A549</td>\n",
       "      <td>IAP</td>\n",
       "      <td>PIK3CA_3</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.146313</td>\n",
       "      <td>2.361266</td>\n",
       "      <td>80.666290</td>\n",
       "      <td>0.014603</td>\n",
       "      <td>0.812595</td>\n",
       "      <td>...</td>\n",
       "      <td>2.618201</td>\n",
       "      <td>3.439598</td>\n",
       "      <td>2.871481</td>\n",
       "      <td>4.590143</td>\n",
       "      <td>3.229038</td>\n",
       "      <td>3.175361</td>\n",
       "      <td>2.883676</td>\n",
       "      <td>3.076011</td>\n",
       "      <td>2.735700</td>\n",
       "      <td>3.173127</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>956</th>\n",
       "      <td>NCI-SNU-16</td>\n",
       "      <td>BCL2_BCL2L1_BCL2L2</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>0.01</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.008408</td>\n",
       "      <td>2.018208</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>1.633028</td>\n",
       "      <td>...</td>\n",
       "      <td>2.933916</td>\n",
       "      <td>3.243823</td>\n",
       "      <td>3.045274</td>\n",
       "      <td>2.875732</td>\n",
       "      <td>3.835860</td>\n",
       "      <td>3.110544</td>\n",
       "      <td>2.892231</td>\n",
       "      <td>3.050573</td>\n",
       "      <td>2.985971</td>\n",
       "      <td>3.047255</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1984</th>\n",
       "      <td>HCC38</td>\n",
       "      <td>MTOR_1</td>\n",
       "      <td>SLC16A4</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.606740</td>\n",
       "      <td>...</td>\n",
       "      <td>2.917921</td>\n",
       "      <td>2.905185</td>\n",
       "      <td>2.619804</td>\n",
       "      <td>2.898116</td>\n",
       "      <td>3.195140</td>\n",
       "      <td>3.023079</td>\n",
       "      <td>2.750002</td>\n",
       "      <td>3.248283</td>\n",
       "      <td>2.824575</td>\n",
       "      <td>3.479549</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>108</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>AKT</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.219929</td>\n",
       "      <td>1.699701</td>\n",
       "      <td>23.856267</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>1.343412</td>\n",
       "      <td>...</td>\n",
       "      <td>3.077701</td>\n",
       "      <td>3.158744</td>\n",
       "      <td>2.937235</td>\n",
       "      <td>2.997616</td>\n",
       "      <td>3.063270</td>\n",
       "      <td>3.105196</td>\n",
       "      <td>2.987275</td>\n",
       "      <td>3.032658</td>\n",
       "      <td>2.863135</td>\n",
       "      <td>3.115976</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1740</th>\n",
       "      <td>HT-29</td>\n",
       "      <td>IAP</td>\n",
       "      <td>PTK2</td>\n",
       "      <td>10.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.454888</td>\n",
       "      <td>1.797221</td>\n",
       "      <td>4.112472</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.974679</td>\n",
       "      <td>2.990945</td>\n",
       "      <td>2.869676</td>\n",
       "      <td>2.717246</td>\n",
       "      <td>3.191157</td>\n",
       "      <td>3.203286</td>\n",
       "      <td>2.924785</td>\n",
       "      <td>2.942057</td>\n",
       "      <td>2.819503</td>\n",
       "      <td>2.918665</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1422</th>\n",
       "      <td>MDA-MB-436</td>\n",
       "      <td>ESR1</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>88.400199</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.110653</td>\n",
       "      <td>2.902860</td>\n",
       "      <td>2.923455</td>\n",
       "      <td>3.358528</td>\n",
       "      <td>3.122761</td>\n",
       "      <td>3.067140</td>\n",
       "      <td>2.973331</td>\n",
       "      <td>2.871706</td>\n",
       "      <td>2.821086</td>\n",
       "      <td>3.165529</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1150</th>\n",
       "      <td>BT-474</td>\n",
       "      <td>Chloroquine</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>100.000000</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>3.397837</td>\n",
       "      <td>2.888975</td>\n",
       "      <td>2.986768</td>\n",
       "      <td>4.945318</td>\n",
       "      <td>3.398761</td>\n",
       "      <td>3.165067</td>\n",
       "      <td>5.305135</td>\n",
       "      <td>3.057982</td>\n",
       "      <td>2.855180</td>\n",
       "      <td>3.541436</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>487</th>\n",
       "      <td>Hs-578-T</td>\n",
       "      <td>AKT_SGK</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.361816</td>\n",
       "      <td>71.621468</td>\n",
       "      <td>0.179870</td>\n",
       "      <td>1.525503</td>\n",
       "      <td>...</td>\n",
       "      <td>2.934290</td>\n",
       "      <td>2.933164</td>\n",
       "      <td>3.104150</td>\n",
       "      <td>3.331712</td>\n",
       "      <td>3.005685</td>\n",
       "      <td>3.162740</td>\n",
       "      <td>2.765877</td>\n",
       "      <td>2.980581</td>\n",
       "      <td>2.814556</td>\n",
       "      <td>3.125973</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>829</th>\n",
       "      <td>BT-549</td>\n",
       "      <td>BCL2_BCL2L1</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>0.10</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.100000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>86.400076</td>\n",
       "      <td>0.256322</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.816639</td>\n",
       "      <td>3.243669</td>\n",
       "      <td>3.413003</td>\n",
       "      <td>3.008486</td>\n",
       "      <td>3.089030</td>\n",
       "      <td>3.195907</td>\n",
       "      <td>2.821349</td>\n",
       "      <td>2.945381</td>\n",
       "      <td>2.914614</td>\n",
       "      <td>3.211485</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1305</th>\n",
       "      <td>BT-549</td>\n",
       "      <td>EGFR</td>\n",
       "      <td>MAP2K_1</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.10</td>\n",
       "      <td>0.022019</td>\n",
       "      <td>4.280291</td>\n",
       "      <td>86.722954</td>\n",
       "      <td>0.001093</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.816639</td>\n",
       "      <td>3.243669</td>\n",
       "      <td>3.413003</td>\n",
       "      <td>3.008486</td>\n",
       "      <td>3.089030</td>\n",
       "      <td>3.195907</td>\n",
       "      <td>2.821349</td>\n",
       "      <td>2.945381</td>\n",
       "      <td>2.914614</td>\n",
       "      <td>3.211485</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>372</th>\n",
       "      <td>BT-20</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>BCL2L1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>0.007812</td>\n",
       "      <td>0.680491</td>\n",
       "      <td>65.454450</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>0.650211</td>\n",
       "      <td>...</td>\n",
       "      <td>2.915575</td>\n",
       "      <td>2.813640</td>\n",
       "      <td>2.799484</td>\n",
       "      <td>3.544658</td>\n",
       "      <td>3.150127</td>\n",
       "      <td>4.029507</td>\n",
       "      <td>2.769985</td>\n",
       "      <td>2.897913</td>\n",
       "      <td>2.823523</td>\n",
       "      <td>3.000220</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>524</th>\n",
       "      <td>M14</td>\n",
       "      <td>AKT_SGK</td>\n",
       "      <td>PIK3C</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.379642</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>63.097704</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>2.933039</td>\n",
       "      <td>6.518348</td>\n",
       "      <td>2.922837</td>\n",
       "      <td>3.023487</td>\n",
       "      <td>3.168739</td>\n",
       "      <td>3.119093</td>\n",
       "      <td>3.526466</td>\n",
       "      <td>3.000046</td>\n",
       "      <td>2.837732</td>\n",
       "      <td>2.966951</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>428</th>\n",
       "      <td>BT-20</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>ESR1_1</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>1.447675</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>79.285827</td>\n",
       "      <td>1.692116</td>\n",
       "      <td>0.905353</td>\n",
       "      <td>...</td>\n",
       "      <td>2.915575</td>\n",
       "      <td>2.813640</td>\n",
       "      <td>2.799484</td>\n",
       "      <td>3.544658</td>\n",
       "      <td>3.150127</td>\n",
       "      <td>4.029507</td>\n",
       "      <td>2.769985</td>\n",
       "      <td>2.897913</td>\n",
       "      <td>2.823523</td>\n",
       "      <td>3.000220</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>354</th>\n",
       "      <td>HCC1569</td>\n",
       "      <td>AKT_1</td>\n",
       "      <td>BCL2_2</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.00</td>\n",
       "      <td>3.000000</td>\n",
       "      <td>0.507908</td>\n",
       "      <td>29.097754</td>\n",
       "      <td>0.908359</td>\n",
       "      <td>0.466200</td>\n",
       "      <td>...</td>\n",
       "      <td>3.040590</td>\n",
       "      <td>3.053810</td>\n",
       "      <td>3.143991</td>\n",
       "      <td>3.137039</td>\n",
       "      <td>3.059061</td>\n",
       "      <td>3.129128</td>\n",
       "      <td>3.080039</td>\n",
       "      <td>3.028000</td>\n",
       "      <td>2.894015</td>\n",
       "      <td>3.278596</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1322</th>\n",
       "      <td>DU-4475</td>\n",
       "      <td>ERBB</td>\n",
       "      <td>FGFR</td>\n",
       "      <td>1.00</td>\n",
       "      <td>1.00</td>\n",
       "      <td>0.027305</td>\n",
       "      <td>10.000000</td>\n",
       "      <td>81.233307</td>\n",
       "      <td>1.000000</td>\n",
       "      <td>0.000000</td>\n",
       "      <td>...</td>\n",
       "      <td>6.641317</td>\n",
       "      <td>3.261940</td>\n",
       "      <td>2.967371</td>\n",
       "      <td>2.931512</td>\n",
       "      <td>2.738748</td>\n",
       "      <td>3.018776</td>\n",
       "      <td>2.882149</td>\n",
       "      <td>2.963330</td>\n",
       "      <td>2.896696</td>\n",
       "      <td>3.053156</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>2154 rows × 69 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "       CELL_LINE          COMPOUND_A   COMPOUND_B  MAX_CONC_A  MAX_CONC_B  \\\n",
       "1120    NCI-H226          CarboTaxol    CSNK2A1_2        0.10        0.01   \n",
       "869   MDA-MB-157         BCL2_BCL2L1         FGFR        1.00        1.00   \n",
       "282      CAL-120                 AKT      PIK3C_2        1.00        1.00   \n",
       "660   MDA-MB-231               ATR_4  BCL2_BCL2L1        1.00        1.00   \n",
       "1923       HCC38             MAP2K_1      SLC16A4        1.00        1.00   \n",
       "671      DMS-114               ATR_4   CarboTaxol        0.01        3.00   \n",
       "1389    KU-19-19                ERBB       MTOR_1        1.00        3.00   \n",
       "2039    BFTC-905               PIK3C         PIM1        3.00        3.00   \n",
       "520      HCC1806             AKT_SGK        PIK3C        1.00        1.00   \n",
       "784        SW620                BCL2       IGFR_4        3.00        0.30   \n",
       "1873        T47D             MAP2K_1        PIK3C        3.00        3.00   \n",
       "1111        A549          CarboTaxol    CSNK2A1_2        0.10        0.01   \n",
       "1499     CAL-148                FASN       MTOR_1        1.00        1.00   \n",
       "551      NCI-H23                 ALK       EGFR_2        1.00        3.00   \n",
       "807    NCI-H1975                BCL2    Topotecan        1.00        3.00   \n",
       "1638        MCF7               HSP90        PARP1        1.00        1.00   \n",
       "515      MFM-223             AKT_SGK      MAP2K_1        1.00        1.00   \n",
       "1371    VM-CUB-1                ERBB      MAP2K_1        3.00        3.00   \n",
       "196    NCI-H1703                 AKT    CSNK2A1_2        0.10        3.00   \n",
       "1798       SW900                 IAP  Vinorelbine        0.10        3.00   \n",
       "1466     HCC1954              ESR1_1        PIK3C        3.00        3.00   \n",
       "2131     DU-4475       PIK3CB_PIK3CD   TNKS_PARP6        1.00        1.00   \n",
       "1470  MDA-MB-453              ESR1_1        PIK3C        3.00        3.00   \n",
       "1324     HCC1395                ERBB         FGFR        1.00        1.00   \n",
       "531    NCI-H1437                 ALK    CSNK2A1_2        0.10        3.00   \n",
       "684    NCI-H2291               ATR_4   CarboTaxol        0.30        3.00   \n",
       "777     NCI-H520                BCL2    CSNK2A1_2        0.03        3.00   \n",
       "1005      CAMA-1              BCL2L1        PIK3C        3.00        3.00   \n",
       "1684    VM-CUB-1                 IAP        PARP1        3.00        0.03   \n",
       "965    NCI-H2170              BCL2L1   CarboTaxol        0.01        3.00   \n",
       "...          ...                 ...          ...         ...         ...   \n",
       "1240   NCI-H2228           CSNK2A1_2      TNFSF10        0.03        0.10   \n",
       "1604    KU-19-19         Gemcitabine        PARP1        3.00        0.10   \n",
       "1270     NCI-H23         Doxorubicin         TOP2        3.00        0.10   \n",
       "1332         M14                ERBB         FGFR        1.00        1.00   \n",
       "1867  MDA-MB-453             MAP2K_1        PIK3C        3.00        3.00   \n",
       "226      HCC1419                 AKT         ERBB        3.00        3.00   \n",
       "830       CAL-51         BCL2_BCL2L1         EGFR        0.10        1.00   \n",
       "815      HCC1187              BCL2_2       EGFR_2        3.00        3.00   \n",
       "421      HCC1143               AKT_1         ESR1        1.00        1.00   \n",
       "408      HCC1419               AKT_1       EGFR_2        3.00        3.00   \n",
       "136      HCC1806                 AKT        ATR_4        1.00        1.00   \n",
       "581      DMS-114               ALK_2       MTOR_1        3.00        3.00   \n",
       "257       KMS-11                 AKT         FGFR        0.03        3.00   \n",
       "796          RKO                BCL2  Oxaliplatin        3.00        3.00   \n",
       "1596      KMS-11                FGFR          WNT        3.00        0.03   \n",
       "1709        A549                 IAP     PIK3CA_3        3.00        3.00   \n",
       "956   NCI-SNU-16  BCL2_BCL2L1_BCL2L2         FGFR        0.01        3.00   \n",
       "1984       HCC38              MTOR_1      SLC16A4        1.00        1.00   \n",
       "108      HCC1806                 AKT        AKT_1        1.00        1.00   \n",
       "1740       HT-29                 IAP         PTK2       10.00        1.00   \n",
       "1422  MDA-MB-436                ESR1         FGFR        1.00        1.00   \n",
       "1150      BT-474         Chloroquine         FGFR        1.00        1.00   \n",
       "487     Hs-578-T             AKT_SGK  BCL2_BCL2L1        1.00        1.00   \n",
       "829       BT-549         BCL2_BCL2L1         EGFR        0.10        1.00   \n",
       "1305      BT-549                EGFR      MAP2K_1        1.00        0.10   \n",
       "372        BT-20               AKT_1       BCL2L1        3.00        3.00   \n",
       "524          M14             AKT_SGK        PIK3C        1.00        1.00   \n",
       "428        BT-20               AKT_1       ESR1_1        3.00        3.00   \n",
       "354      HCC1569               AKT_1       BCL2_2        3.00        3.00   \n",
       "1322     DU-4475                ERBB         FGFR        1.00        1.00   \n",
       "\n",
       "        IC50_A        H_A      Einf_A    IC50_B        H_B    ...     \\\n",
       "1120  0.004267   1.957945    0.000000  0.001606   3.191878    ...      \n",
       "869   0.037093   2.848411   38.622217  1.000000   0.000000    ...      \n",
       "282   1.000000  10.000000   62.600248  0.244725   2.877772    ...      \n",
       "660   1.000000   0.757933    1.701477  0.972413   9.996671    ...      \n",
       "1923  1.000000   0.000000  100.000000  0.241770   4.489731    ...      \n",
       "671   0.001789   2.931865   10.639634  1.060265  10.000000    ...      \n",
       "1389  1.000000  10.000000   56.600823  1.000000   0.000000    ...      \n",
       "2039  3.000000   0.337757   80.476441  1.453983   0.795855    ...      \n",
       "520   0.305450  10.000000   20.899430  0.339596  10.000000    ...      \n",
       "784   3.000000   1.618277   43.744349  0.002947  10.000000    ...      \n",
       "1873  0.166243   0.978454   11.286392  0.014740   0.925424    ...      \n",
       "1111  0.015534   4.405409    7.787490  0.002395   5.267135    ...      \n",
       "1499  0.081707   3.042215   81.184951  1.000000   0.000000    ...      \n",
       "551   0.000100   0.100000   80.738188  0.048314   0.996378    ...      \n",
       "807   0.170760   3.460592   25.019012  0.797019   2.260090    ...      \n",
       "1638  0.402211   2.172594   78.262462  0.036303   2.611075    ...      \n",
       "515   1.000000   0.183281   92.498101  0.159500   1.360827    ...      \n",
       "1371  0.295627   1.207419   74.800075  0.000300   0.100000    ...      \n",
       "196   0.010633   3.211180   11.333820  0.006865   0.663950    ...      \n",
       "1798  0.019645   2.972307   32.862210  2.078708   0.160256    ...      \n",
       "1466  0.979539  10.000000   20.398874  3.000000   1.800982    ...      \n",
       "2131  0.018177   2.918650    2.525304  0.186303  10.000000    ...      \n",
       "1470  1.074279   1.380102    0.000000  3.000000   1.267985    ...      \n",
       "1324  0.009375   1.413786   47.213513  1.000000   0.321879    ...      \n",
       "531   0.009940   1.991152    8.494214  0.763935   0.964060    ...      \n",
       "684   0.004500   1.112722   53.213744  1.307301  10.000000    ...      \n",
       "777   0.007215   1.601308   15.403837  1.000000   0.000000    ...      \n",
       "1005  1.192237  10.000000   31.293248  1.000000   0.000000    ...      \n",
       "1684  0.152387  10.000000   86.021772  0.004546   2.540027    ...      \n",
       "965   0.002673  10.000000    7.697676  0.346608   1.066233    ...      \n",
       "...        ...        ...         ...       ...        ...    ...      \n",
       "1240  0.008426   2.269674   33.221896  0.027232   0.687339    ...      \n",
       "1604  1.000000   0.000000  100.000000  0.003773   2.510380    ...      \n",
       "1270  3.000000   0.874108   20.708785  0.015070   1.003054    ...      \n",
       "1332  1.000000   0.000000  100.000000  0.199644  10.000000    ...      \n",
       "1867  0.927035   1.562516    0.000000  3.000000   1.489434    ...      \n",
       "226   0.140781   1.101064   18.453283  0.623293   0.564782    ...      \n",
       "830   0.000822   6.824547   93.050346  0.181424   0.985490    ...      \n",
       "815   1.000000   0.000000  100.000000  1.000000   0.000000    ...      \n",
       "421   1.000000   0.000000  100.000000  0.168050   0.843434    ...      \n",
       "408   0.528474   1.524840   36.904572  0.132235   1.014869    ...      \n",
       "136   0.510325   2.634897    0.000000  1.000000   1.991181    ...      \n",
       "581   0.151997   1.179879   13.464204  3.000000   0.470659    ...      \n",
       "257   0.030000  10.000000   28.201761  1.078691  10.000000    ...      \n",
       "796   2.782220  10.000000    0.000000  0.028861   1.471660    ...      \n",
       "1596  1.035844   1.615199    0.000000  0.030000  10.000000    ...      \n",
       "1709  0.146313   2.361266   80.666290  0.014603   0.812595    ...      \n",
       "956   0.008408   2.018208    0.000000  3.000000   1.633028    ...      \n",
       "1984  1.000000   0.000000  100.000000  1.000000   0.606740    ...      \n",
       "108   0.219929   1.699701   23.856267  1.000000   1.343412    ...      \n",
       "1740  0.454888   1.797221    4.112472  1.000000  10.000000    ...      \n",
       "1422  1.000000  10.000000   88.400199  1.000000   0.000000    ...      \n",
       "1150  1.000000   0.000000  100.000000  1.000000   0.000000    ...      \n",
       "487   1.000000   0.361816   71.621468  0.179870   1.525503    ...      \n",
       "829   0.100000  10.000000   86.400076  0.256322  10.000000    ...      \n",
       "1305  0.022019   4.280291   86.722954  0.001093  10.000000    ...      \n",
       "372   0.007812   0.680491   65.454450  3.000000   0.650211    ...      \n",
       "524   0.379642  10.000000   63.097704  1.000000  10.000000    ...      \n",
       "428   1.447675  10.000000   79.285827  1.692116   0.905353    ...      \n",
       "354   3.000000   0.507908   29.097754  0.908359   0.466200    ...      \n",
       "1322  0.027305  10.000000   81.233307  1.000000   0.000000    ...      \n",
       "\n",
       "       SCGB3A1    PLXNC1   ZMYND10    RASSF2      PAEP     DMBT1    SLC5A8  \\\n",
       "1120  3.196587  3.105170  2.758353  2.904278  3.244633  3.106455  2.967927   \n",
       "869   3.417108  2.848206  3.142725  2.936310  3.007921  3.054710  2.756604   \n",
       "282   3.034160  2.935529  3.573663  2.876825  3.128143  3.035675  2.835125   \n",
       "660   3.181619  3.926466  2.869493  3.546421  2.951307  3.182094  2.956081   \n",
       "1923  2.917921  2.905185  2.619804  2.898116  3.195140  3.023079  2.750002   \n",
       "671   3.108994  2.900969  3.393863  3.532048  2.939697  3.020590  2.719290   \n",
       "1389  2.971459  3.787799  2.994033  3.091832  3.257342  3.143533  2.988031   \n",
       "2039  3.008259  2.942337  2.777214  2.799285  3.048194  3.259930  2.902307   \n",
       "520   3.077701  3.158744  2.937235  2.997616  3.063270  3.105196  2.987275   \n",
       "784   3.051775  3.345778  2.891563  2.985521  3.041921  3.626924  2.963113   \n",
       "1873  3.529014  2.963293  5.392502  2.947590  2.966073  3.279402  2.932696   \n",
       "1111  2.618201  3.439598  2.871481  4.590143  3.229038  3.175361  2.883676   \n",
       "1499  2.999705  2.747906  3.610392  3.089765  3.152753  3.512786  3.080372   \n",
       "551   3.105895  3.064982  2.980468  3.382724  2.782616  3.244990  3.046582   \n",
       "807   2.889549  3.388011  2.653350  3.004391  5.483910  3.127484  2.966180   \n",
       "1638  2.810044  3.138420  3.121148  3.285233  3.020808  3.418069  2.947500   \n",
       "515   3.074193  3.119683  2.852664  2.831212  3.331895  3.090648  2.909637   \n",
       "1371  2.763581  3.058533  2.941588  2.954028  3.242681  3.381658  3.162877   \n",
       "196   3.100216  2.796563  3.050630  3.922159  2.992315  3.186393  2.943426   \n",
       "1798  3.000264  3.359064  2.677600  3.275909  3.593650  3.113598  2.751693   \n",
       "1466  2.808530  2.813112  2.820790  2.840546  2.949892  3.620413  2.817355   \n",
       "2131  6.641317  3.261940  2.967371  2.931512  2.738748  3.018776  2.882149   \n",
       "1470  3.339377  2.929715  3.101365  3.071616  2.979513  3.920466  2.819317   \n",
       "1324  3.335179  3.120729  2.840833  2.996178  2.762244  3.262841  2.914026   \n",
       "531   3.130618  3.165875  2.975913  3.229888  3.244565  3.249300  3.136237   \n",
       "684   3.045388  3.425525  2.927099  2.969691  3.247989  3.064667  2.981434   \n",
       "777   3.192131  3.342862  3.071031  3.045198  3.012284  3.227953  3.022355   \n",
       "1005  2.929818  3.257416  2.998274  2.953413  3.029040  3.226411  4.161931   \n",
       "1684  2.763581  3.058533  2.941588  2.954028  3.242681  3.381658  3.162877   \n",
       "965   3.249636  3.055646  3.134305  2.850209  3.757147  3.094029  3.034178   \n",
       "...        ...       ...       ...       ...       ...       ...       ...   \n",
       "1240  2.815644  3.691472  2.871655  2.853733  3.231701  2.913922  2.801132   \n",
       "1604  2.971459  3.787799  2.994033  3.091832  3.257342  3.143533  2.988031   \n",
       "1270  3.105895  3.064982  2.980468  3.382724  2.782616  3.244990  3.046582   \n",
       "1332  2.933039  6.518348  2.922837  3.023487  3.168739  3.119093  3.526466   \n",
       "1867  3.339377  2.929715  3.101365  3.071616  2.979513  3.920466  2.819317   \n",
       "226   3.143145  3.051578  3.167154  2.695011  3.283737  3.176259  2.946651   \n",
       "830   2.802066  2.971389  2.716059  2.798442  3.483779  3.031597  2.639684   \n",
       "815   3.453242  2.806844  2.906644  3.273166  3.164783  3.285630  2.926218   \n",
       "421   2.919405  2.929893  2.804370  3.004955  3.174471  3.134975  2.728687   \n",
       "408   3.143145  3.051578  3.167154  2.695011  3.283737  3.176259  2.946651   \n",
       "136   3.077701  3.158744  2.937235  2.997616  3.063270  3.105196  2.987275   \n",
       "581   3.108994  2.900969  3.393863  3.532048  2.939697  3.020590  2.719290   \n",
       "257   3.216024  3.765180  3.107443  3.219757  3.416491  3.210491  2.970834   \n",
       "796   3.285907  3.318851  2.833059  3.042848  3.152022  3.203563  3.015670   \n",
       "1596  3.216024  3.765180  3.107443  3.219757  3.416491  3.210491  2.970834   \n",
       "1709  2.618201  3.439598  2.871481  4.590143  3.229038  3.175361  2.883676   \n",
       "956   2.933916  3.243823  3.045274  2.875732  3.835860  3.110544  2.892231   \n",
       "1984  2.917921  2.905185  2.619804  2.898116  3.195140  3.023079  2.750002   \n",
       "108   3.077701  3.158744  2.937235  2.997616  3.063270  3.105196  2.987275   \n",
       "1740  2.974679  2.990945  2.869676  2.717246  3.191157  3.203286  2.924785   \n",
       "1422  3.110653  2.902860  2.923455  3.358528  3.122761  3.067140  2.973331   \n",
       "1150  3.397837  2.888975  2.986768  4.945318  3.398761  3.165067  5.305135   \n",
       "487   2.934290  2.933164  3.104150  3.331712  3.005685  3.162740  2.765877   \n",
       "829   2.816639  3.243669  3.413003  3.008486  3.089030  3.195907  2.821349   \n",
       "1305  2.816639  3.243669  3.413003  3.008486  3.089030  3.195907  2.821349   \n",
       "372   2.915575  2.813640  2.799484  3.544658  3.150127  4.029507  2.769985   \n",
       "524   2.933039  6.518348  2.922837  3.023487  3.168739  3.119093  3.526466   \n",
       "428   2.915575  2.813640  2.799484  3.544658  3.150127  4.029507  2.769985   \n",
       "354   3.040590  3.053810  3.143991  3.137039  3.059061  3.129128  3.080039   \n",
       "1322  6.641317  3.261940  2.967371  2.931512  2.738748  3.018776  2.882149   \n",
       "\n",
       "          CHD5  TMPRSS11A    PCDH10  \n",
       "1120  3.017443   3.012289  3.069359  \n",
       "869   3.424931   2.837982  3.256840  \n",
       "282   3.107214   2.796175  3.089691  \n",
       "660   3.136598   2.861495  3.060358  \n",
       "1923  3.248283   2.824575  3.479549  \n",
       "671   4.446063   2.762481  3.215187  \n",
       "1389  3.292097   2.752586  3.111552  \n",
       "2039  2.998725   4.267372  2.889307  \n",
       "520   3.032658   2.863135  3.115976  \n",
       "784   3.179157   2.959542  3.041055  \n",
       "1873  3.392055   2.999052  3.113202  \n",
       "1111  3.076011   2.735700  3.173127  \n",
       "1499  3.226845   2.904799  2.967150  \n",
       "551   3.299269   2.910972  3.186866  \n",
       "807   3.039337   2.945612  3.032989  \n",
       "1638  3.102655   3.003778  3.026654  \n",
       "515   2.904436   2.918381  3.036467  \n",
       "1371  3.109847   2.923276  3.117340  \n",
       "196   3.154295   2.990087  7.430479  \n",
       "1798  3.045676   2.914748  3.095914  \n",
       "1466  3.242901   2.894186  3.033169  \n",
       "2131  2.963330   2.896696  3.053156  \n",
       "1470  2.917080   2.780886  3.151810  \n",
       "1324  2.998041   2.995132  4.135256  \n",
       "531   3.121637   2.910373  3.226794  \n",
       "684   3.220535   2.950242  3.071855  \n",
       "777   3.016550   2.949874  3.013212  \n",
       "1005  3.143544   2.863846  3.028737  \n",
       "1684  3.109847   2.923276  3.117340  \n",
       "965   3.061812   3.131563  3.063637  \n",
       "...        ...        ...       ...  \n",
       "1240  2.967801   2.843641  2.940855  \n",
       "1604  3.292097   2.752586  3.111552  \n",
       "1270  3.299269   2.910972  3.186866  \n",
       "1332  3.000046   2.837732  2.966951  \n",
       "1867  2.917080   2.780886  3.151810  \n",
       "226   2.895803   2.869254  3.024603  \n",
       "830   2.951518   2.736339  2.880854  \n",
       "815   3.041712   2.839010  3.042895  \n",
       "421   3.255077   2.752513  2.999672  \n",
       "408   2.895803   2.869254  3.024603  \n",
       "136   3.032658   2.863135  3.115976  \n",
       "581   4.446063   2.762481  3.215187  \n",
       "257   3.027391   2.817485  3.439833  \n",
       "796   3.216483   2.896112  2.992803  \n",
       "1596  3.027391   2.817485  3.439833  \n",
       "1709  3.076011   2.735700  3.173127  \n",
       "956   3.050573   2.985971  3.047255  \n",
       "1984  3.248283   2.824575  3.479549  \n",
       "108   3.032658   2.863135  3.115976  \n",
       "1740  2.942057   2.819503  2.918665  \n",
       "1422  2.871706   2.821086  3.165529  \n",
       "1150  3.057982   2.855180  3.541436  \n",
       "487   2.980581   2.814556  3.125973  \n",
       "829   2.945381   2.914614  3.211485  \n",
       "1305  2.945381   2.914614  3.211485  \n",
       "372   2.897913   2.823523  3.000220  \n",
       "524   3.000046   2.837732  2.966951  \n",
       "428   2.897913   2.823523  3.000220  \n",
       "354   3.028000   2.894015  3.278596  \n",
       "1322  2.963330   2.896696  3.053156  \n",
       "\n",
       "[2154 rows x 69 columns]"
      ]
     },
     "execution_count": 107,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "for i, row in dfmod.iterrows():\n",
    "    cl = row['CELL_LINE']\n",
    "    for tsg in tsgex.index:\n",
    "        if cl in tsgex.columns:\n",
    "            dfmod.set_value(i, tsg, tsgex.ix[tsg, cl])\n",
    "        else:\n",
    "            dfmod.set_value(i, tsg, np.mean(tsgex.loc[tsg]))  # if no cell line gex data available, assume mean of gex\n",
    "                                                              # cases: MDA-MB-175-VII and NCI-H1437\n",
    "dfmod"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 108,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "ymod = dfmod['SYNERGY_SCORE'].values\n",
    "Xmod = pd.get_dummies(dfmod.drop(['SYNERGY_SCORE'], axis=1), columns=['CELL_LINE', 'COMPOUND_A', 'COMPOUND_B', 'Disease_area']).values"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 109,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "0.646812045651\n",
      "0.643797026162\n",
      "0.642687747266\n"
     ]
    }
   ],
   "source": [
    "for i in range(3):\n",
    "    gbr = GradientBoostingRegressor(n_estimators=1000, max_depth=5, loss='huber',\n",
    "                                        max_features='log2', learning_rate=0.03)\n",
    "    pearsons = cross_validation.cross_val_score(gbr, Xmod, ymod, scoring=pearson_scorer, cv=5) #scoring=pearson_scorer, \n",
    "    print(np.mean(pearsons))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 92,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "False"
      ]
     },
     "execution_count": 92,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "any(tsgex.loc['ZYX'] > 10)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### tsgene - mutation correlation"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 110,
   "metadata": {
    "collapsed": false,
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Cell_line</th>\n",
       "      <th>Gene</th>\n",
       "      <th>Mutation</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>TXNDC11</td>\n",
       "      <td>Unknown</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>MUC16</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>MUC16</td>\n",
       "      <td>Substitution - Nonsense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>UBE2M</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>MLL3</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>GCC2</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>RAPGEF3</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>HCC1806</td>\n",
       "      <td>GALM</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>KRAS</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>SLC16A14</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>TROAP</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>PEX6</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>LRP12</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>CKAP2</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>TMTC2</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>PHYH</td>\n",
       "      <td>Unknown</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>OR4K5</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>OR4K5</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>IQSEC3</td>\n",
       "      <td>Unknown</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>EML5</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>SLC26A7</td>\n",
       "      <td>Unknown</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>TXNL1</td>\n",
       "      <td>Unknown</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>NLRP13</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>SEPSECS</td>\n",
       "      <td>Insertion - In frame</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>PTPRK</td>\n",
       "      <td>Unknown</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>EML5</td>\n",
       "      <td>Unknown</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>MUC16</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>27</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>ASZ1</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>28</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>F5</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29</th>\n",
       "      <td>NCI-H358</td>\n",
       "      <td>NUP37</td>\n",
       "      <td>Substitution - Nonsense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1528</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>GABBR1</td>\n",
       "      <td>Unknown</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1529</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>CASP2</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1530</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>ZNF862</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1531</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>SQLE</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1532</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>CCDC30</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1533</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>GPR112</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1534</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>HCFC2</td>\n",
       "      <td>Unknown</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1535</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>RAB11FIP3</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1536</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>LCMT2</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1537</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>ZBTB33</td>\n",
       "      <td>Substitution - Nonsense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1538</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>ZNF627</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1539</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>ZNF43</td>\n",
       "      <td>Unknown</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1540</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>FBXL19</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1541</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>TAF2</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1542</th>\n",
       "      <td>CAL-148</td>\n",
       "      <td>RABEP2</td>\n",
       "      <td>Unknown</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1543</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>SMARCA4</td>\n",
       "      <td>Unknown</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1544</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>SAMD3</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1545</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>TEX15</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1546</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>TRHDE</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1547</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>OR2G2</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1548</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>KCNG4</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1549</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>ZNF831</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1550</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>CENPO</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1551</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>DARS</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1552</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>SYNE1</td>\n",
       "      <td>Unknown</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1553</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>S1PR1</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1554</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>GABRA4</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1555</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>PRSS36</td>\n",
       "      <td>Deletion - Frameshift</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1556</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>TBP</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1557</th>\n",
       "      <td>NCI-H1299</td>\n",
       "      <td>GDF5OS</td>\n",
       "      <td>Substitution - Missense</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>1558 rows × 3 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "      Cell_line       Gene                 Mutation\n",
       "0       HCC1806    TXNDC11                  Unknown\n",
       "1       HCC1806      MUC16  Substitution - Missense\n",
       "2       HCC1806      MUC16  Substitution - Nonsense\n",
       "3       HCC1806      UBE2M  Substitution - Missense\n",
       "4       HCC1806       MLL3  Substitution - Missense\n",
       "5       HCC1806       GCC2  Substitution - Missense\n",
       "6       HCC1806    RAPGEF3  Substitution - Missense\n",
       "7       HCC1806       GALM  Substitution - Missense\n",
       "8      NCI-H358       KRAS  Substitution - Missense\n",
       "9      NCI-H358   SLC16A14  Substitution - Missense\n",
       "10     NCI-H358      TROAP  Substitution - Missense\n",
       "11     NCI-H358       PEX6  Substitution - Missense\n",
       "12     NCI-H358      LRP12  Substitution - Missense\n",
       "13     NCI-H358      CKAP2  Substitution - Missense\n",
       "14     NCI-H358      TMTC2  Substitution - Missense\n",
       "15     NCI-H358       PHYH                  Unknown\n",
       "16     NCI-H358      OR4K5  Substitution - Missense\n",
       "17     NCI-H358      OR4K5  Substitution - Missense\n",
       "18     NCI-H358     IQSEC3                  Unknown\n",
       "19     NCI-H358       EML5  Substitution - Missense\n",
       "20     NCI-H358    SLC26A7                  Unknown\n",
       "21     NCI-H358      TXNL1                  Unknown\n",
       "22     NCI-H358     NLRP13  Substitution - Missense\n",
       "23     NCI-H358    SEPSECS     Insertion - In frame\n",
       "24     NCI-H358      PTPRK                  Unknown\n",
       "25     NCI-H358       EML5                  Unknown\n",
       "26     NCI-H358      MUC16  Substitution - Missense\n",
       "27     NCI-H358       ASZ1  Substitution - Missense\n",
       "28     NCI-H358         F5  Substitution - Missense\n",
       "29     NCI-H358      NUP37  Substitution - Nonsense\n",
       "...         ...        ...                      ...\n",
       "1528    CAL-148     GABBR1                  Unknown\n",
       "1529    CAL-148      CASP2  Substitution - Missense\n",
       "1530    CAL-148     ZNF862  Substitution - Missense\n",
       "1531    CAL-148       SQLE  Substitution - Missense\n",
       "1532    CAL-148     CCDC30  Substitution - Missense\n",
       "1533    CAL-148     GPR112  Substitution - Missense\n",
       "1534    CAL-148      HCFC2                  Unknown\n",
       "1535    CAL-148  RAB11FIP3  Substitution - Missense\n",
       "1536    CAL-148      LCMT2  Substitution - Missense\n",
       "1537    CAL-148     ZBTB33  Substitution - Nonsense\n",
       "1538    CAL-148     ZNF627  Substitution - Missense\n",
       "1539    CAL-148      ZNF43                  Unknown\n",
       "1540    CAL-148     FBXL19  Substitution - Missense\n",
       "1541    CAL-148       TAF2  Substitution - Missense\n",
       "1542    CAL-148     RABEP2                  Unknown\n",
       "1543  NCI-H1299    SMARCA4                  Unknown\n",
       "1544  NCI-H1299      SAMD3  Substitution - Missense\n",
       "1545  NCI-H1299      TEX15  Substitution - Missense\n",
       "1546  NCI-H1299      TRHDE  Substitution - Missense\n",
       "1547  NCI-H1299      OR2G2  Substitution - Missense\n",
       "1548  NCI-H1299      KCNG4  Substitution - Missense\n",
       "1549  NCI-H1299     ZNF831  Substitution - Missense\n",
       "1550  NCI-H1299      CENPO  Substitution - Missense\n",
       "1551  NCI-H1299       DARS  Substitution - Missense\n",
       "1552  NCI-H1299      SYNE1                  Unknown\n",
       "1553  NCI-H1299      S1PR1  Substitution - Missense\n",
       "1554  NCI-H1299     GABRA4  Substitution - Missense\n",
       "1555  NCI-H1299     PRSS36    Deletion - Frameshift\n",
       "1556  NCI-H1299        TBP  Substitution - Missense\n",
       "1557  NCI-H1299     GDF5OS  Substitution - Missense\n",
       "\n",
       "[1558 rows x 3 columns]"
      ]
     },
     "execution_count": 110,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "cgm"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 113,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "array(['TXNDC11', 'MUC16', 'MUC16', 'UBE2M', 'MLL3', 'GCC2', 'RAPGEF3',\n",
       "       'GALM'], dtype=object)"
      ]
     },
     "execution_count": 113,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "cgm[cgm['Cell_line']=='HCC1806']['Gene'].values"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 114,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0"
      ]
     },
     "execution_count": 114,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "hcc1806_muts = cgm[cgm['Cell_line']=='HCC1806']['Gene'].values\n",
    "len(set(hcc1806_muts) & set(ts2_genes))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 125,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "tsg_count = {}\n",
    "for index, row in mut.iterrows():\n",
    "    gene = row['Gene.name']\n",
    "    cell_line = row['cell_line_name']\n",
    "    tsg_count[cell_line] = int(gene in ts2_genes or gene in ts1_genes)  "
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 126,
   "metadata": {
    "collapsed": false,
    "scrolled": true
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "{'22RV1': 0,\n",
       " '647-V': 0,\n",
       " 'A549': 1,\n",
       " 'BFTC-905': 0,\n",
       " 'BT-20': 0,\n",
       " 'BT-474': 0,\n",
       " 'BT-549': 0,\n",
       " 'C32': 0,\n",
       " 'CAL-120': 0,\n",
       " 'CAL-148': 0,\n",
       " 'CAL-51': 0,\n",
       " 'CAMA-1': 0,\n",
       " 'COLO-205': 0,\n",
       " 'Calu-3': 0,\n",
       " 'Calu-6': 0,\n",
       " 'DMS-114': 0,\n",
       " 'DU-4475': 0,\n",
       " 'EVSA-T': 0,\n",
       " 'HCC1143': 0,\n",
       " 'HCC1187': 0,\n",
       " 'HCC1395': 1,\n",
       " 'HCC1419': 0,\n",
       " 'HCC1428': 0,\n",
       " 'HCC1500': 0,\n",
       " 'HCC1569': 0,\n",
       " 'HCC1806': 0,\n",
       " 'HCC1937': 0,\n",
       " 'HCC1954': 0,\n",
       " 'HCC38': 0,\n",
       " 'HCC70': 0,\n",
       " 'HCT-116': 0,\n",
       " 'HT-1197': 0,\n",
       " 'HT-1376': 0,\n",
       " 'HT-29': 0,\n",
       " 'Hs-578-T': 0,\n",
       " 'J82': 0,\n",
       " 'KATOIII': 0,\n",
       " 'KMS-11': 0,\n",
       " 'KU-19-19': 0,\n",
       " 'LS-513': 0,\n",
       " 'M14': 0,\n",
       " 'MCF7': 0,\n",
       " 'MDA-MB-157': 0,\n",
       " 'MDA-MB-175-VII': 0,\n",
       " 'MDA-MB-231': 0,\n",
       " 'MDA-MB-361': 0,\n",
       " 'MDA-MB-415': 0,\n",
       " 'MDA-MB-436': 0,\n",
       " 'MDA-MB-453': 1,\n",
       " 'MDA-MB-468': 0,\n",
       " 'MFM-223': 0,\n",
       " 'NCI-H1299': 0,\n",
       " 'NCI-H1437': 0,\n",
       " 'NCI-H1563': 0,\n",
       " 'NCI-H1703': 1,\n",
       " 'NCI-H1793': 0,\n",
       " 'NCI-H1975': 0,\n",
       " 'NCI-H2085': 0,\n",
       " 'NCI-H2170': 0,\n",
       " 'NCI-H2228': 0,\n",
       " 'NCI-H226': 0,\n",
       " 'NCI-H2291': 0,\n",
       " 'NCI-H23': 0,\n",
       " 'NCI-H3122': 0,\n",
       " 'NCI-H358': 0,\n",
       " 'NCI-H520': 0,\n",
       " 'NCI-H522': 0,\n",
       " 'NCI-H747': 0,\n",
       " 'NCI-H838': 0,\n",
       " 'NCI-SNU-16': 0,\n",
       " 'RKO': 0,\n",
       " 'RT4': 0,\n",
       " 'SW48': 0,\n",
       " 'SW620': 0,\n",
       " 'SW780': 0,\n",
       " 'SW837': 0,\n",
       " 'SW900': 0,\n",
       " 'SW948': 0,\n",
       " 'T-24': 0,\n",
       " 'T47D': 0,\n",
       " 'TCCSUP': 0,\n",
       " 'UACC-812': 0,\n",
       " 'UM-UC-3': 0,\n",
       " 'VCaP': 0,\n",
       " 'VM-CUB-1': 1}"
      ]
     },
     "execution_count": 126,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "tsg_count"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 131,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "dfmod['tsmut'] = 0\n",
    "for i, row in dfmod.iterrows():\n",
    "    cl = row['CELL_LINE']\n",
    "    dfmod.set_value(i, 'tsmut', tsg_count[cl])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 137,
   "metadata": {
    "collapsed": false
   },
   "outputs": [],
   "source": [
    "ymod = dfmod['SYNERGY_SCORE'].values\n",
    "Xmod = pd.get_dummies(dfmod.drop(['SYNERGY_SCORE'], axis=1), columns=['CELL_LINE', 'COMPOUND_A', 'COMPOUND_B', 'Disease_area']).values"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 150,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "0.638682748795\n",
      "0.637380983898\n",
      "0.641575100621\n"
     ]
    }
   ],
   "source": [
    "for i in range(3):\n",
    "    gbr = GradientBoostingRegressor(n_estimators=1000, max_depth=5, loss='huber',\n",
    "                                        max_features='log2', learning_rate=0.03)\n",
    "    pearsons = cross_validation.cross_val_score(gbr, Xmod, ymod, scoring=pearson_scorer, cv=5) #scoring=pearson_scorer, \n",
    "    print(np.mean(pearsons))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 302,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0.052414030656180034"
      ]
     },
     "execution_count": 302,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "3189/17419"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 303,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "3189.4216867469881"
      ]
     },
     "execution_count": 303,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "mean_overex = 0\n",
    "for col in gex.columns:\n",
    "    mean = np.mean(gex[col].values)\n",
    "    std = np.std(gex[col].values)\n",
    "    overex = np.sum(gex[col].values > mean + std)\n",
    "    mean_overex += overex\n",
    "mean_overex/83"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 297,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "456"
      ]
     },
     "execution_count": 297,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "np.sum(gex['22RV1'].values > 10)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "import matplotlib.pyplot as plt\n",
    "%matplotlib inline \n",
    "plt.rcParams['figure.figsize'] = (10, 6)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 285,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "X_train, X_test, y_train, y_test = cross_validation.train_test_split(Xmod, ymod, train_size=0.85)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 287,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "ename": "KeyboardInterrupt",
     "evalue": "",
     "output_type": "error",
     "traceback": [
      "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m",
      "\u001b[0;31mKeyboardInterrupt\u001b[0m                         Traceback (most recent call last)",
      "\u001b[0;32m<ipython-input-287-a2076641a27f>\u001b[0m in \u001b[0;36m<module>\u001b[0;34m()\u001b[0m\n\u001b[1;32m      3\u001b[0m     gbr = GradientBoostingRegressor(n_estimators=1000, max_depth=7,\n\u001b[1;32m      4\u001b[0m                                     max_features='log2', learning_rate=0.03)\n\u001b[0;32m----> 5\u001b[0;31m     \u001b[0mgbr\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mfit\u001b[0m\u001b[0;34m(\u001b[0m\u001b[0mX_train\u001b[0m\u001b[0;34m,\u001b[0m \u001b[0my_train\u001b[0m\u001b[0;34m)\u001b[0m\u001b[0;34m\u001b[0m\u001b[0m\n\u001b[0m\u001b[1;32m      6\u001b[0m     \u001b[0mpearson\u001b[0m \u001b[0;34m=\u001b[0m \u001b[0mstats\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mpearsonr\u001b[0m\u001b[0;34m(\u001b[0m\u001b[0my_test\u001b[0m\u001b[0;34m,\u001b[0m \u001b[0mgbr\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mpredict\u001b[0m\u001b[0;34m(\u001b[0m\u001b[0mX_test\u001b[0m\u001b[0;34m)\u001b[0m\u001b[0;34m)\u001b[0m\u001b[0;34m[\u001b[0m\u001b[0;36m0\u001b[0m\u001b[0;34m]\u001b[0m\u001b[0;34m\u001b[0m\u001b[0m\n\u001b[1;32m      7\u001b[0m \u001b[0mprint\u001b[0m\u001b[0;34m(\u001b[0m\u001b[0mpearson\u001b[0m\u001b[0;34m)\u001b[0m\u001b[0;34m\u001b[0m\u001b[0m\n",
      "\u001b[0;32m/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/sklearn/ensemble/gradient_boosting.py\u001b[0m in \u001b[0;36mfit\u001b[0;34m(self, X, y, sample_weight, monitor)\u001b[0m\n\u001b[1;32m    978\u001b[0m         \u001b[0;31m# fit the boosting stages\u001b[0m\u001b[0;34m\u001b[0m\u001b[0;34m\u001b[0m\u001b[0m\n\u001b[1;32m    979\u001b[0m         n_stages = self._fit_stages(X, y, y_pred, sample_weight, random_state,\n\u001b[0;32m--> 980\u001b[0;31m                                     begin_at_stage, monitor)\n\u001b[0m\u001b[1;32m    981\u001b[0m         \u001b[0;31m# change shape of arrays after fit (early-stopping or additional ests)\u001b[0m\u001b[0;34m\u001b[0m\u001b[0;34m\u001b[0m\u001b[0m\n\u001b[1;32m    982\u001b[0m         \u001b[0;32mif\u001b[0m \u001b[0mn_stages\u001b[0m \u001b[0;34m!=\u001b[0m \u001b[0mself\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mestimators_\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mshape\u001b[0m\u001b[0;34m[\u001b[0m\u001b[0;36m0\u001b[0m\u001b[0;34m]\u001b[0m\u001b[0;34m:\u001b[0m\u001b[0;34m\u001b[0m\u001b[0m\n",
      "\u001b[0;32m/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/sklearn/ensemble/gradient_boosting.py\u001b[0m in \u001b[0;36m_fit_stages\u001b[0;34m(self, X, y, y_pred, sample_weight, random_state, begin_at_stage, monitor)\u001b[0m\n\u001b[1;32m   1038\u001b[0m             y_pred = self._fit_stage(i, X, y, y_pred, sample_weight,\n\u001b[1;32m   1039\u001b[0m                                      \u001b[0msample_mask\u001b[0m\u001b[0;34m,\u001b[0m \u001b[0mcriterion\u001b[0m\u001b[0;34m,\u001b[0m \u001b[0msplitter\u001b[0m\u001b[0;34m,\u001b[0m\u001b[0;34m\u001b[0m\u001b[0m\n\u001b[0;32m-> 1040\u001b[0;31m                                      random_state)\n\u001b[0m\u001b[1;32m   1041\u001b[0m \u001b[0;34m\u001b[0m\u001b[0m\n\u001b[1;32m   1042\u001b[0m             \u001b[0;31m# track deviance (= loss)\u001b[0m\u001b[0;34m\u001b[0m\u001b[0;34m\u001b[0m\u001b[0m\n",
      "\u001b[0;32m/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/sklearn/ensemble/gradient_boosting.py\u001b[0m in \u001b[0;36m_fit_stage\u001b[0;34m(self, i, X, y, y_pred, sample_weight, sample_mask, criterion, splitter, random_state)\u001b[0m\n\u001b[1;32m    764\u001b[0m \u001b[0;34m\u001b[0m\u001b[0m\n\u001b[1;32m    765\u001b[0m             tree.fit(X, residual, sample_weight=sample_weight,\n\u001b[0;32m--> 766\u001b[0;31m                      check_input=False)\n\u001b[0m\u001b[1;32m    767\u001b[0m \u001b[0;34m\u001b[0m\u001b[0m\n\u001b[1;32m    768\u001b[0m             \u001b[0;31m# update tree leaves\u001b[0m\u001b[0;34m\u001b[0m\u001b[0;34m\u001b[0m\u001b[0m\n",
      "\u001b[0;32m/Library/Frameworks/Python.framework/Versions/3.4/lib/python3.4/site-packages/sklearn/tree/tree.py\u001b[0m in \u001b[0;36mfit\u001b[0;34m(self, X, y, sample_weight, check_input)\u001b[0m\n\u001b[1;32m    302\u001b[0m                                            max_leaf_nodes)\n\u001b[1;32m    303\u001b[0m \u001b[0;34m\u001b[0m\u001b[0m\n\u001b[0;32m--> 304\u001b[0;31m         \u001b[0mbuilder\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mbuild\u001b[0m\u001b[0;34m(\u001b[0m\u001b[0mself\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mtree_\u001b[0m\u001b[0;34m,\u001b[0m \u001b[0mX\u001b[0m\u001b[0;34m,\u001b[0m \u001b[0my\u001b[0m\u001b[0;34m,\u001b[0m \u001b[0msample_weight\u001b[0m\u001b[0;34m)\u001b[0m\u001b[0;34m\u001b[0m\u001b[0m\n\u001b[0m\u001b[1;32m    305\u001b[0m \u001b[0;34m\u001b[0m\u001b[0m\n\u001b[1;32m    306\u001b[0m         \u001b[0;32mif\u001b[0m \u001b[0mself\u001b[0m\u001b[0;34m.\u001b[0m\u001b[0mn_outputs_\u001b[0m \u001b[0;34m==\u001b[0m \u001b[0;36m1\u001b[0m\u001b[0;34m:\u001b[0m\u001b[0;34m\u001b[0m\u001b[0m\n",
      "\u001b[0;31mKeyboardInterrupt\u001b[0m: "
     ]
    }
   ],
   "source": [
    "pearson = 0\n",
    "while pearson < 0.70:\n",
    "    gbr = GradientBoostingRegressor(n_estimators=1000, max_depth=7,\n",
    "                                    max_features='log2', learning_rate=0.03)\n",
    "    gbr.fit(X_train, y_train)\n",
    "    pearson = stats.pearsonr(y_test, gbr.predict(X_test))[0]\n",
    "print(pearson)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 247,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "image/png": 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ADNTWrsWePTvx+ee/AlDcwtWdnU/Y9ufzuzrq62M6zZoFXHJJ+v4DDwTWrAm+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\n",
      "text/plain": [
       "<matplotlib.figure.Figure at 0x1133c9e10>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "x = y_test\n",
    "y = gbr.predict(X_test)\n",
    "plt.scatter(x, y)\n",
    "plt.plot(x, x, 'k--')\n",
    "\n",
    "m, b = np.polyfit(x, y, 1)\n",
    "plt.plot(x, m*x + b, 'b--')\n",
    "\n",
    "plt.axis([-120, 120, -120, 120])\n",
    "plt.title(\"Predicted vs. True Values for Synergy\")\n",
    "plt.xlabel(\"True synergy\")\n",
    "plt.ylabel(\"Predicted synergy\")\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Classification"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 145,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "from sklearn.ensemble import GradientBoostingClassifier"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 250,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "def class_pred(graph=False):\n",
    "    #Yclass = ymod > 0\n",
    "    Yclass = ymod > np.mean(ymod)+np.std(ymod)\n",
    "    Yclass = Yclass.astype(int)\n",
    "    \n",
    "    for i in range(3):\n",
    "        gbc = GradientBoostingClassifier(n_estimators=1000, max_depth=5, loss='exponential',\n",
    "                                    max_features='log2', learning_rate=0.03)\n",
    "        accuracies = cross_validation.cross_val_score(gbc, Xmod, Yclass, cv=5)\n",
    "\n",
    "        print(\"Classification accuracy: \" + str(np.mean(accuracies)))\n",
    "        #print(\"AUC: \" + str(metrics.roc_auc_score(y_test, pred)))\n",
    "        #print(\"F1: \" + str(metrics.f1_score(y_test, pred)))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 251,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Classification accuracy: 0.925719382443\n",
      "Classification accuracy: 0.926647451693\n",
      "Classification accuracy: 0.926184493726\n"
     ]
    }
   ],
   "source": [
    "class_pred()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 162,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "from scipy import interp"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 271,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": [
    "def graph_roc():\n",
    "#     Yclass = (ymod > 0).astype(int)\n",
    "    Yclass = ymod > np.mean(ymod)+0.5*np.std(ymod)\n",
    "    Yclass = Yclass.astype(int)\n",
    "\n",
    "    # Run classifier with cross-validation and plot ROC curves\n",
    "    cv = cross_validation.StratifiedKFold(Yclass, n_folds=5)\n",
    "    classifier = GradientBoostingClassifier(n_estimators=1000, max_depth=7, loss='exponential',\n",
    "                                    max_features='log2', learning_rate=0.03)\n",
    "\n",
    "    mean_tpr = 0.0\n",
    "    mean_fpr = np.linspace(0, 1, 100)\n",
    "    all_tpr = []\n",
    "\n",
    "    for i, (train, test) in enumerate(cv):\n",
    "        probas_ = classifier.fit(Xmod[train], Yclass[train]).predict_proba(Xmod[test])\n",
    "        # Compute ROC curve and area the curve\n",
    "        fpr, tpr, thresholds = metrics.roc_curve(Yclass[test], probas_[:, 1])\n",
    "        mean_tpr += interp(mean_fpr, fpr, tpr)\n",
    "        mean_tpr[0] = 0.0\n",
    "        roc_auc = metrics.auc(fpr, tpr)\n",
    "        plt.plot(fpr, tpr, lw=1, label='ROC fold %d (area = %0.2f)' % (i, roc_auc))\n",
    "\n",
    "    plt.plot([0, 1], [0, 1], '--', color=(0.6, 0.6, 0.6), label='Luck')\n",
    "\n",
    "    mean_tpr /= len(cv)\n",
    "    mean_tpr[-1] = 1.0\n",
    "    mean_auc = metrics.auc(mean_fpr, mean_tpr)\n",
    "    plt.plot(mean_fpr, mean_tpr, 'k--',\n",
    "             label='Mean ROC (area = %0.2f)' % mean_auc, lw=2)\n",
    "\n",
    "    plt.xlim([-0.05, 1.05])\n",
    "    plt.ylim([-0.05, 1.05])\n",
    "    plt.xlabel('False Positive Rate')\n",
    "    plt.ylabel('True Positive Rate')\n",
    "    plt.title('ROC Synergy Prediction')\n",
    "    plt.legend(loc=\"lower right\")\n",
    "    plt.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 272,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "image/png": 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ze9c5Nxi4FzgEODISwUr98y0tMq/iCvU//vgjJ598Mj/++CPvvvsu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\nAElFTkSuQmCC\n",
      "text/plain": [
       "<matplotlib.figure.Figure at 0x113444ba8>"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "graph_roc()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 270,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "168"
      ]
     },
     "execution_count": 270,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "test_Yclass = ymod > np.mean(ymod)+np.std(ymod)\n",
    "np.sum(test_Yclass)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 266,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "2154"
      ]
     },
     "execution_count": 266,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(test_Yclass)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 267,
   "metadata": {
    "collapsed": false
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "0.2265552460538533"
      ]
     },
     "execution_count": 267,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "488/2154"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {
    "collapsed": true
   },
   "outputs": [],
   "source": []
  }
 ],
 "metadata": {
  "kernelspec": {
   "display_name": "Python 3",
   "language": "python",
   "name": "python3"
  },
  "language_info": {
   "codemirror_mode": {
    "name": "ipython",
    "version": 3
   },
   "file_extension": ".py",
   "mimetype": "text/x-python",
   "name": "python",
   "nbconvert_exporter": "python",
   "pygments_lexer": "ipython3",
   "version": "3.4.3"
  }
 },
 "nbformat": 4,
 "nbformat_minor": 0
}