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how to get indel hotspot with this software #15

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feihongloveworld opened this issue Nov 12, 2019 · 1 comment
Open

how to get indel hotspot with this software #15

feihongloveworld opened this issue Nov 12, 2019 · 1 comment

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@feihongloveworld
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feihongloveworld commented Nov 12, 2019

hi sir:
there are many indel hotspot discovery in the paper of "Accelerating discovery of functional mutant alleles in cancer" as below:
#================
We identified 1,165 statistically significant hotspot mutations of which 80% arose in 1 in 1,000 or fewer patients. Of 55 recurrent in-frame indels, we validated that novel AKT1 duplications induced pathway hyperactivation and conferred AKT inhibitor sensitivity.
#=================
but the hotspot soft will Discard the ins and del in soft script.
how can i get indel hotpsot in mydata?
thanks

@feihongloveworld feihongloveworld changed the title about how to get indel hotspot with this software Nov 12, 2019
@feihongloveworld
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there is a code line in "funcs.R" as below:

maf=maf[ which(!maf$Variant_Type%in%c('INS','DEL')), ]

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