diff --git a/Wrapping/Generators/Python/Tests/PythonTemplateTest.py b/Wrapping/Generators/Python/Tests/PythonTemplateTest.py
index e429b5c9744..b32ab72f0d6 100644
--- a/Wrapping/Generators/Python/Tests/PythonTemplateTest.py
+++ b/Wrapping/Generators/Python/Tests/PythonTemplateTest.py
@@ -119,6 +119,17 @@
 median_kwarg = itk.MedianImageFilter.New(Input=reader.GetOutput())
 assert itk.class_(median) == itk.class_(median_kwarg)
 
+# filter type determined by the input passed as a primary input name input
+median_primary_kwarg = itk.MedianImageFilter.New(Primary=reader.GetOutput())
+assert itk.class_(median) == itk.class_(median_primary_kwarg)
+
+# First RequiredInputName: "FixedImage"
+fixed_image = reader.GetOutput()
+moving_image = fixed_image
+pde_registration = itk.PDEDeformableRegistrationFilter.New(
+    FixedImage=fixed_image, MovingImage=moving_image
+)
+
 # to a filter with a SetImage method
 calculator = itk.MinimumMaximumImageCalculator[ImageType].New(reader)
 # not GetImage() method here to verify it's the right image
diff --git a/Wrapping/Generators/Python/Tests/extras.py b/Wrapping/Generators/Python/Tests/extras.py
index aa03f539194..96eed9c743f 100644
--- a/Wrapping/Generators/Python/Tests/extras.py
+++ b/Wrapping/Generators/Python/Tests/extras.py
@@ -163,6 +163,18 @@ def custom_callback(name, progress):
 image = itk.imread(filename, imageio=itk.PNGImageIO.New())
 assert type(image) == itk.Image[itk.RGBPixel[itk.UC], 2]
 
+# Python functional interface that determines the filter type
+# based on the primary input (dispatch)
+image = itk.imread(filename, itk.UC)
+# positional argument
+filtered_positional = itk.median_image_filter(image)
+# required primary named input argument
+filtered_kwarg = itk.median_image_filter(primary=image)
+comparison = itk.comparison_image_filter(
+    filtered_positional, filtered_kwarg, verify_input_information=True
+)
+assert np.sum(comparison) == 0.0
+
 # imread using a dicom series
 image = itk.imread(sys.argv[8])
 image0 = itk.imread(sys.argv[8], series_uid=0)
diff --git a/Wrapping/Generators/Python/itk/support/extras.py b/Wrapping/Generators/Python/itk/support/extras.py
index 5116b086655..c4c90272777 100644
--- a/Wrapping/Generators/Python/itk/support/extras.py
+++ b/Wrapping/Generators/Python/itk/support/extras.py
@@ -39,6 +39,7 @@
 from .helpers import wasm_type_from_image_type, image_type_from_wasm_type
 from .helpers import wasm_type_from_mesh_type, mesh_type_from_wasm_type, python_to_js
 from .helpers import wasm_type_from_pointset_type, pointset_type_from_wasm_type
+from .helpers import snake_to_camel_case
 
 from .xarray import xarray_from_image, image_from_xarray
 
@@ -1552,17 +1553,6 @@ def search(s: str, case_sensitive: bool = False) -> List[str]:  # , fuzzy=True):
     return res
 
 
-def _snake_to_camel(keyword: str):
-    # Helpers for set_inputs snake case to CamelCase keyword argument conversion
-    _snake_underscore_re = re.compile("(_)([a-z0-9A-Z])")
-
-    def _underscore_upper(match_obj):
-        return match_obj.group(2).upper()
-
-    camel = keyword[0].upper()
-    if _snake_underscore_re.search(keyword[1:]):
-        return camel + _snake_underscore_re.sub(_underscore_upper, keyword[1:])
-    return camel + keyword[1:]
 
 
 def set_inputs(
@@ -1656,7 +1646,7 @@ def SetInputs(self, *args, **kargs):
         # (Ex: itk.ImageFileReader.UC2.New(SetFileName='image.png'))
         if attribName not in ["auto_progress", "template_parameters"]:
             if attribName.islower():
-                attribName = _snake_to_camel(attribName)
+                attribName = snake_to_camel_case(attribName)
             attrib = getattr(new_itk_object, "Set" + attribName)
 
             # Do not use try-except mechanism as this leads to
@@ -2162,7 +2152,7 @@ def ipython_kw_matches(text: str):
             namespace = split_name_parts[:-1]
             function_name = split_name_parts[-1]
             # Find corresponding object name
-            object_name = _snake_to_camel(function_name)
+            object_name = snake_to_camel_case(function_name)
             # Check that this object actually exists
             try:
                 object_callable_match = ".".join(namespace + [object_name])
diff --git a/Wrapping/Generators/Python/itk/support/helpers.py b/Wrapping/Generators/Python/itk/support/helpers.py
index 5ff75eb8270..32a16fda540 100644
--- a/Wrapping/Generators/Python/itk/support/helpers.py
+++ b/Wrapping/Generators/Python/itk/support/helpers.py
@@ -40,6 +40,18 @@
     pass
 
 
+def snake_to_camel_case(keyword: str):
+    # Helpers for set_inputs snake case to CamelCase keyword argument conversion
+    _snake_underscore_re = re.compile("(_)([a-z0-9A-Z])")
+
+    def _underscore_upper(match_obj):
+        return match_obj.group(2).upper()
+
+    camel = keyword[0].upper()
+    if _snake_underscore_re.search(keyword[1:]):
+        return camel + _snake_underscore_re.sub(_underscore_upper, keyword[1:])
+    return camel + keyword[1:]
+
 def camel_to_snake_case(name):
     snake = re.sub("(.)([A-Z][a-z]+)", r"\1_\2", name)
     snake = re.sub("([a-z0-9])([A-Z])", r"\1_\2", snake)
diff --git a/Wrapping/Generators/Python/itk/support/template_class.py b/Wrapping/Generators/Python/itk/support/template_class.py
index 9601df7976c..3a14333a527 100644
--- a/Wrapping/Generators/Python/itk/support/template_class.py
+++ b/Wrapping/Generators/Python/itk/support/template_class.py
@@ -30,6 +30,7 @@
 from itk.support import base
 from itk.support.extras import output
 from itk.support.types import itkCType
+from itk.support.helpers import snake_to_camel_case
 import math
 from collections.abc import Mapping
 
@@ -718,6 +719,20 @@ def ttype_for_input_type(keys_l, input_type_l):
             # try to find a type suitable for the input provided
             input_type = output(cur).__class__
             keys = ttype_for_input_type(keys, input_type)
+        else:
+            inst = self.values()[0].New()
+            if hasattr(inst, "GetRequiredInputNames"):
+                required_input_names = inst.GetRequiredInputNames()
+                if len(required_input_names) > 0:
+                    primary_input_name = required_input_names[0]
+                    kwargs_camel = {snake_to_camel_case(k): v for k,v in kwargs.items()}
+                    if primary_input_name in kwargs_camel.keys():
+                        input_type = output(kwargs_camel[primary_input_name]).__class__
+                        keys = ttype_for_input_type(keys, input_type)
+                        if not hasattr(inst, f"Set{primary_input_name}"):
+                            arg_0 = kwargs_camel.pop(primary_input_name)
+                            kwargs = kwargs_camel
+                            args = (arg_0,) + args
 
         if len(keys) == 0:
             if not input_type: