diff --git a/setup.cfg b/setup.cfg
index 5db7b47d..41000901 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -30,6 +30,7 @@ python_requires = >=3.7
 install_requires =
     pydantic[email]>=1.0
     xmlschema>=1.0.16
+    Pint>=0.15
 
 [options.package_data]
 * = *.xsd
diff --git a/src/ome_types/dataclasses.py b/src/ome_types/dataclasses.py
index 475b641b..a9be1ae1 100644
--- a/src/ome_types/dataclasses.py
+++ b/src/ome_types/dataclasses.py
@@ -6,6 +6,7 @@
 from textwrap import indent
 from typing import TYPE_CHECKING, Any, Callable, Optional, Sequence, Type, Union
 
+import pint
 from pydantic import validator
 from pydantic.dataclasses import _process_class
 
@@ -13,6 +14,13 @@
     from pydantic.dataclasses import DataclassType
 
 
+ureg = pint.UnitRegistry(auto_reduce_dimensions=True)
+ureg.define("reference_frame = [_reference_frame]")
+ureg.define("@alias grade = gradian")
+ureg.define("@alias astronomical_unit = ua")
+ureg.define("line = inch / 12 = li")
+
+
 class Sentinel:
     """Create singleton sentinel objects with a readable repr."""
 
@@ -89,6 +97,22 @@ def new_post_init(self: Any, *args: Any) -> None:
     setattr(_cls, "__post_init__", new_post_init)
 
 
+def add_quantities(_cls: Type[Any]) -> None:
+    value_fields = [f for f in dir(_cls) if f + "_unit" in dir(_cls)]
+    for field in value_fields:
+        setattr(_cls, field + "_quantity", quantity_property(field))
+
+
+def quantity_property(field: str) -> property:
+    def quantity(self: Any) -> Optional[pint.Quantity]:
+        value = getattr(self, field)
+        if value is None:
+            return None
+        unit = getattr(self, field + "_unit").value.replace(' ', '_')
+        return ureg.Quantity(value, unit)
+    return property(quantity)
+
+
 def modify_repr(_cls: Type[Any]) -> None:
     """Improved dataclass repr function.
 
@@ -153,6 +177,7 @@ def wrap(cls: Type[Any]) -> DataclassType:
         if getattr(cls, "id", None) is AUTO_SEQUENCE:
             setattr(cls, "validate_id", validate_id)
         modify_post_init(cls)
+        add_quantities(cls)
         if not repr:
             modify_repr(cls)
         return _process_class(cls, init, repr, eq, order, unsafe_hash, frozen, config)
diff --git a/testing/test_units.py b/testing/test_units.py
new file mode 100644
index 00000000..765d6ce0
--- /dev/null
+++ b/testing/test_units.py
@@ -0,0 +1,62 @@
+import pytest
+from pydantic import ValidationError
+from pint import DimensionalityError
+from ome_types.model import Channel, Laser, Plane
+from ome_types.dataclasses import ureg
+
+
+def test_quantity_math():
+    """Validate math on quantities with different but compatible units."""
+    channel = Channel(
+        excitation_wavelength=475,
+        excitation_wavelength_unit="nm",
+        emission_wavelength=530000,
+        emission_wavelength_unit="pm",
+    )
+    shift = (
+        channel.emission_wavelength_quantity - channel.excitation_wavelength_quantity
+    )
+    # Compare to a tolerance due to Pint internal factor representation.
+    assert abs(shift.to("nm").m - 55) < 1e-12
+
+
+def test_invalid_unit():
+    """Ensure incompatible units in constructor raises ValidationError."""
+    with pytest.raises(ValidationError):
+        Channel(
+            excitation_wavelength=475, excitation_wavelength_unit="kg",
+        )
+
+
+def test_dimensionality_error():
+    """Ensure math on incompatible units raises DimensionalityError."""
+    laser = Laser(
+        id="LightSource:1",
+        repetition_rate=10,
+        repetition_rate_unit="MHz",
+        wavelength=640,
+    )
+    with pytest.raises(DimensionalityError):
+        laser.repetition_rate_quantity + laser.wavelength_quantity
+
+
+def test_reference_frame():
+    """Validate reference_frame behavior."""
+    plane = Plane(
+        the_c=0,
+        the_t=0,
+        the_z=0,
+        position_x=1,
+        position_x_unit="reference frame",
+        position_y=2,
+        position_y_unit="mm",
+    )
+    # Verify two different ways that reference_frame and length are incompatible.
+    with pytest.raises(DimensionalityError):
+        plane.position_x_quantity + plane.position_y_quantity
+    product = plane.position_x_quantity * plane.position_y_quantity
+    assert not product.check("[area]")
+    # Verify that we can obtain a usable length if we know the conversion factor.
+    conversion_factor = ureg.Quantity(1, "micron/reference_frame")
+    position_x = plane.position_x_quantity * conversion_factor
+    assert position_x.check("[length]")